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https://www.readbyqxmd.com/read/28104554/abnormalities-in-metabolite-concentrations-in-tourette-s-disorder-and-obsessive-compulsive-disorder-a-proton-magnetic-resonance-spectroscopy-study
#1
Siyan Fan, Danielle C Cath, Odile A van den Heuvel, Ysbrand D van der Werf, Caroline Schöls, Dick J Veltman, Petra J W Pouwels
INTRODUCTION: Abnormal glutamatergic transmission in cortico-striato-thalamo-cortical (CSTC) circuits is thought to be involved in the pathophysiology of Tourette's disorder (TD) and obsessive-compulsive disorder (OCD). Using proton magnetic resonance spectroscopy, the current study aimed to investigate regional concentrations of glutamatergic compounds in TD and OCD patients in comparison to healthy control subjects (HC). MATERIAL AND METHODS: Twenty-three TD patients, 20 OCD patients and 22 HC were included...
January 4, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28104431/abnormal-regional-spontaneous-neuronal-activity-associated-with-symptom-severity-in-treatment-naive-patients-with-obsessive-compulsive-disorder-revealed-by-resting-state-functional-mri
#2
Linlin Qiu, Xiangshuai Fu, Shuai Wang, Qunfeng Tang, Xingui Chen, Lin Cheng, Fuquan Zhang, Zhenhe Zhou, Lin Tian
A large number of neuroimaging studies have revealed the dysfunction of brain activities in obsessive-compulsive disorder (OCD) during various tasks. However, regional spontaneous activity abnormalities in OCD are gradually being revealed. In this current study, we aimed to investigate cerebral regions with abnormal spontaneous activity using resting-state functional magnetic resonance imaging (fMRI) and further explored the relationship between the spontaneous neuronal activity and symptom severity of patients with OCD...
January 16, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28096676/aripiprazole-augmentation-in-managing-comorbid-obsessive-compulsive-disorder-and-bipolar-disorder-a-case-with-suicidal-attempts
#3
Jianbo Lai, Qiaoqiao Lu, Peng Zhang, Tingting Xu, Yi Xu, Shaohua Hu
Comorbid obsessive-compulsive disorder (OCD) and bipolar disorder (BD) have long been an intractable problem in clinical practice. The increased risk of manic/hypomanic switch hinders the use of antidepressants for managing coexisting OCD symptoms in BD patients. We herein present a case of a patient with BD-OCD comorbidity, who was successfully treated with mood stabilizers and aripiprazole augmentation. The young female patient reported recurrent depressive episodes and aggravating compulsive behaviors before hospitalization...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28096674/alterations-of-white-matter-fractional-anisotropy-in-unmedicated-obsessive-compulsive-disorder
#4
Jiong Tao, Xianglan Wang, Zhiyong Zhong, Hongying Han, Sha Liu, Shenglin Wen, Nianhong Guan, Lingjiang Li
BACKGROUND: Abnormalities in white matter (WM) have previously been reported in patients with obsessive-compulsive disorder (OCD). However, there was some inconsistency in the results obtained for altered regions of WM. The aim of this study was to investigate fractional anisotropy (FA) in the WM of the whole brain in patients with OCD by using diffusion tensor imaging (DTI). METHODS: In total, 28 unmedicated patients with OCD and 28 healthy volunteers underwent DTI scan...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28095945/conflict-monitoring-and-adaptation-as-reflected-by-n2-amplitude-in-obsessive-compulsive-disorder
#5
A Riesel, J Klawohn, N Kathmann, T Endrass
BACKGROUND: Feelings of doubt and perseverative behaviours are key symptoms of obsessive-compulsive disorder (OCD) and have been linked to hyperactive error and conflict signals in the brain. While enhanced neural correlates of error monitoring have been robustly shown, far less is known about conflict processing and adaptation in OCD. METHOD: We examined event-related potentials during conflict processing in 70 patients with OCD and 70 matched healthy comparison participants, focusing on the stimulus-locked N2 elicited in a flanker task...
January 18, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28093822/the-role-of-guilt-sensitivity-in-ocd-symptom-dimensions
#6
Gabriele Melli, Claudia Carraresi, Andrea Poli, Donatella Marazziti, Antonio Pinto
: Although some studies have found that guilt may precede, motivate, or be a consequence of obsessive-compulsive disorder (OCD), the relationship between guilt and OCD has been under investigated. The studies that explored the role of trait guilt (guilt propensity) in OCD reported inconsistent findings and failed to support its predictive role. Since it has been suggested that OCD patients perceive guilt in a more threatening manner, it might also be relevant to test to what extent they negatively evaluate the experience of guilt (i...
January 16, 2017: Clinical Psychology & Psychotherapy
https://www.readbyqxmd.com/read/28090807/neurocognitive-function-in-pediatric-obsessive-compulsive-disorder
#7
Daniel A Geller, Amitai Abramovitch, Andrew Mittelman, Abigail Stark, Kesley Ramsey, Allison Cooperman, Lee Baer, S Evelyn Stewart
OBJECTIVES: The small body of neuropsychological research in pediatric OCD yields inconsistent results. A recent meta-analysis found small effect sizes, concluding that pediatric OCD may not be associated with cognitive impairments, stressing the need for more research. We investigated neuropsychological performance in a large sample of OCD youth, while assessing potential moderators. METHODS: Participants with OCD (n = 102), and matched controls (n = 161) were thoroughly screened and blindly evaluated for comorbidities, and completed a neuropsychological battery assessing processing-speed, visuospatial abilities (VSA), working memory (WM), nonverbal memory (NVM), and executive functions (EF)...
January 16, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28087165/radiographic-comparison-of-adolescent-athletes-with-elbow-osteochondritis-dissecans-to-ulnar-collateral-ligament-injuries-and-controls
#8
Brian C Lau, Nirav K Pandya
BACKGROUND: There are excellent data supporting recommendations to prevent elbow injuries (osteochondritis dissecans [OCD] and ulnar collateral ligament [UCL] injuries), such as pitch count and pitch type in baseball, but anatomic risk factors have not been thoroughly examined. This study aimed to evaluate radiographic measurements in adolescents with elbow OCD lesions or UCL injuries and controls. METHODS: We retrospectively identified adolescent patients between 2011 and 2016 with isolated capitellum OCD, UCL tear, or normal elbows based on magnetic resonance imaging...
January 10, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28078209/cognitive-behavioural-therapy-for-obsessive-compulsive-disorder-co-occurring-with-psychosis-systematic-review-of-evidence
#9
Antonio Tundo, Roberta Necci
AIM: To review available evidence on the use of cognitive behavioural therapy (CBT) for treating obsessive compulsive disorder co-occurring with psychosis. METHODS: In this paper we present a detailed and comprehensive review of the current literature focusing on CBT treatment of obsessive compulsive disorder (OCD) co-occurring with schizophrenia or schizoaffective disorder. We identified relevant literature published between 2001 and May 2016 through MEDLINE/PubMed search using as search string ("obsessive compulsive disorders" or "obsessive compulsive symptoms") and ("schizophrenia" or "schizoaffective disorder" or "psychosis") and ("cognitive behavioural therapy")...
December 22, 2016: World Journal of Psychiatry
https://www.readbyqxmd.com/read/28072701/pathophysiology-of-refractory-obsessive-compulsive-disorder-a-study-of-visual-search-combined-with-overactive-performance-monitoring
#10
Qingxiao Liu, Bo Tan, Jing Zhou, Zhong Zheng, Ling Li, Yanchun Yang
Based on both functional and structural studies of excessive activity, fronto-striatal-thalamic-cortical and cortico-striatal circuits have been hypothesized to underlie the pathophysiology of obsessive-compulsive disorder (OCD). However, the neurobiological underpinnings of OCD refractory to medication and therapy remain controversial. This study aimed to evaluate neuroanatomical abnormalities of the whole brain and to evaluate visual processing in patients with refractory OCD.This study was comprised of 2 experiments...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28070247/effectiveness-of-cognitive-behavioral-therapy-and-fluoxetine-on-sexual-function-of-women-with-obsessive-compulsive-disorder-a-double-blind-randomized-controlled-trial
#11
Zahra Sabetnejad, Fatemeh Assarian, Abdollah Omidi, Mohammad Reza Najarzadegan
BACKGROUND: Obsessive compulsive disorder (OCD) is a mental health concern due to its various negative consequences, especially in sexual function. Therefore, the treatment of sexual dysfunction in women with OCD is important in order to improve the patient's marital function and mental health. OBJECTIVES: To compare the sexual behavior and sexual and marital satisfaction in women with obsessive-compulsive disorder (OCD) before and after treatment with fluoxetine and cognitive behavior therapy...
November 2016: Electronic Physician
https://www.readbyqxmd.com/read/28070119/ocd-like-behavior-is-caused-by-dysfunction-of-thalamo-amygdala-circuits-and-upregulated-trkb-erk-mapk-signaling-as-a-result-of-spred2-deficiency
#12
M Ullrich, M Weber, A M Post, S Popp, J Grein, M Zechner, H Guerrero González, A Kreis, A G Schmitt, N Üçeyler, K-P Lesch, K Schuh
Obsessive-compulsive disorder (OCD) is a common neuropsychiatric disease affecting about 2% of the general population. It is characterized by persistent intrusive thoughts and repetitive ritualized behaviors. While gene variations, malfunction of cortico-striato-thalamo-cortical (CSTC) circuits, and dysregulated synaptic transmission have been implicated in the pathogenesis of OCD, the underlying mechanisms remain largely unknown. Here we show that OCD-like behavior in mice is caused by deficiency of SPRED2, a protein expressed in various brain regions and a potent inhibitor of Ras/ERK-MAPK signaling...
January 10, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28066002/management-of-obsessive-compulsive-disorder-comorbid-with-bipolar-disorder
#13
REVIEW
Firoz Kazhungil, E Mohandas
Obsessive-compulsive disorder (OCD) is one of the most common comorbidities in bipolar disorder (BD). Clinicians often get perplexed in making treatment decisions when encountering comorbid OCD and BD as treatment of OCD by pharmacotherapy may induce or exacerbate mood instability and psychotherapeutic approaches for OCD may not be feasible in acute manic or depressive state of BD. In this study, we reviewed literature, whether existing guideline-based treatments of BD may be effective in OCD and whether newer agents will be of use for treating this comorbidity...
July 2016: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28065182/increased-fronto-striatal-reward-prediction-errors-moderate-decision-making-in-obsessive-compulsive-disorder
#14
T U Hauser, R Iannaccone, R J Dolan, J Ball, J Hättenschwiler, R Drechsler, M Rufer, D Brandeis, S Walitza, S Brem
BACKGROUND: Obsessive-compulsive disorder (OCD) has been linked to functional abnormalities in fronto-striatal networks as well as impairments in decision making and learning. Little is known about the neurocognitive mechanisms causing these decision-making and learning deficits in OCD, and how they relate to dysfunction in fronto-striatal networks. METHOD: We investigated neural mechanisms of decision making in OCD patients, including early and late onset of disorder, in terms of reward prediction errors (RPEs) using functional magnetic resonance imaging...
January 9, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28065178/investigating-the-role-of-anticipatory-reward-and-habit-strength-in-obsessive-compulsive-disorder
#15
Gabriela M Ferreira, Murat Yücel, Andrew Dawson, Valentina Lorenzetti, Leonardo F Fontenelle
: Aims To determine the rates and associated illness characteristics of obsessive-compulsive disorder (OCD) patients who describe their symptoms as either rewarding or habitual. METHODS: Seventy-three treatment-seeking OCD patients had their dominant compulsive behavior assessed with a structured interview (the Temporal Impulsive-Compulsive Scale-Revised) to track the progression of rewarding (ie, gain in positive affect), aversive (ie, decrease in negative affect), and neutral (or non-affective) states and a self-report scale (the Self-Report Habit Index) to evaluate their habitual features...
January 9, 2017: CNS Spectrums
https://www.readbyqxmd.com/read/28063400/relationships-between-neuropsychological-variables-and-factor-analysed-symptom-dimensions-in-obsessive-compulsive-disorder
#16
Himani Kashyap, J Keshav Kumar, Thennarasu Kandavel, Y C Janardhan Reddy
Despite mounting evidence for the distinctiveness of symptom dimensions in obsessive-compulsive disorder, neuropsychological studies have been few, focused on small samples, and relying on classification of participants based on mutually exclusive symptom categories, resulting in lack of concordance across neuropsychological and imaging studies. Neuropsychological assessment was undertaken with 150 individuals with DSM IV OCD, and neuropsychological variables were analysed in relation to symptom dimension scores derived from factor analysis...
December 29, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/28057396/inverse-reasoning-processes-in-obsessive-compulsive-disorder
#17
Shiu F Wong, Jessica R Grisham
The inference-based approach (IBA) is one cognitive model that aims to explain the aetiology and maintenance of obsessive-compulsive disorder (OCD). The model proposes that certain reasoning processes lead an individual with OCD to confuse an imagined possibility with an actual probability, a state termed inferential confusion. One such reasoning process is inverse reasoning, in which hypothetical causes form the basis of conclusions about reality. Although previous research has found associations between a self-report measure of inferential confusion and OCD symptoms, evidence of a specific association between inverse reasoning and OCD symptoms is lacking...
December 28, 2016: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/28052778/co-morbid-obsessive-compulsive-disorder-and-depression-a-bayesian-network-approach
#18
R J McNally, P Mair, B L Mugno, B C Riemann
BACKGROUND: Obsessive-compulsive disorder (OCD) is often co-morbid with depression. Using the methods of network analysis, we computed two networks that disclose the potentially causal relationships among symptoms of these two disorders in 408 adult patients with primary OCD and co-morbid depression symptoms. METHOD: We examined the relationship between the symptoms constituting these syndromes by computing a (regularized) partial correlation network via the graphical LASSO procedure, and a directed acyclic graph (DAG) via a Bayesian hill-climbing algorithm...
January 5, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28044255/mavoglurant-augmentation-in-ocd-patients-resistant-to-selective-serotonin-reuptake-inhibitors-a-proof-of-concept-randomized-placebo-controlled-phase-2-study
#19
Daniel Rutrick, Dan J Stein, Ganesan Subramanian, Brian Smith, Maurizio Fava, Gregor Hasler, Jang-Ho Cha, Fabrizio Gasparini, Toni Donchev, Magdalena Ocwieja, Donald Johns, Baltazar Gomez-Mancilla
INTRODUCTION: To determine if mavoglurant (modified release) as an augmentation therapy to selective serotonin reuptake inhibitors (SSRIs) could have beneficial effects reducing Yale-Brown Obsessive Compulsive Scale (Y-BOCS) total score in patients with obsessive-compulsive disorder (OCD) resistant to SSRI treatment. METHODS: This was a multicenter, randomized, double-blind, placebo-controlled, parallel-group, phase 2 study. Patients remained on their SSRI treatment and mavoglurant or placebo was added on...
January 2, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28041946/hyperactive-performance-monitoring-as-a-transdiagnostic-marker-results-from-health-anxiety-in-comparison-to-obsessive-compulsive-disorder
#20
Anja Riesel, Stefanie Goldhahn, Norbert Kathmann
Hyperactive error-related brain activity has been found in individuals with obsessive-compulsive disorder (OCD), generalized and social anxiety as well as depression and has been proposed as a transdiagnostic marker. The specific phenotype to which it is related is still debated and anxious apprehension, threat sensitivity and checking have been proposed as promising candidates. To validate the idea that hyperactive performance monitoring is shared by anxiety and anxiety-related disorders and to refine our knowledge about its specificity, data from further anxiety and anxiety-related disorders are required...
December 29, 2016: Neuropsychologia
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