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https://www.readbyqxmd.com/read/29244201/sleep-disturbances-in-treatment-seeking-ocd-patients-changes-after-concentrated-exposure-treatment
#1
Håkon Nordahl, Audun Havnen, Bjarne Hansen, Lars-Göran Öst, Gerd Kvale
Research indicates that patients with Obsessive Compulsive Disorder (OCD) frequently suffer from comorbid sleep difficulties, and that these difficulties often are not clinically recognized and diagnosed. There has been limited research investigating if comorbid sleep difficulties impair treatment outcome for OCD and if the sleep difficulties change following OCD-treatment. Thirty-six patients with obsessive compulsive disorder underwent concentrated exposure treatment delivered in a group over four consecutive days and were assessed with measures of OCD, depressive symptoms and sleep disturbance at three different time points (pre, post and 6 months follow-up)...
December 15, 2017: Scandinavian Journal of Psychology
https://www.readbyqxmd.com/read/29240023/immediate-effects-of-transcranial-direct-current-stimulation-on-obsession-induced-anxiety-in-refractory-obsessive-compulsive-disorder-a-pilot-study
#2
Doron Todder, Adi Gershi, Zvi Perry, Zeev Kaplan, Joseph Levine, Keren Avirame
OBJECTIVE: Studies have shown that transcranial direct current stimulation (tDCS) has immediate effects on brain activity. The aim of this study was to investigate the potential use of tDCS to regulate obsession-induced anxiety immediately after symptom provocation in patients with refractory obsessive-compulsive disorder (OCD). METHODS: Twelve patients with refractory OCD received cathode, anode, and sham transcranial direct current stimulation over the medial prefrontal cortex conjugant to pharmacological treatment in a crossover design...
December 12, 2017: Journal of ECT
https://www.readbyqxmd.com/read/29239120/a-call-for-prevention-and-early-intervention-in-obsessive-compulsive-disorder
#3
REVIEW
Vlasios Brakoulias, Iain E Perkes, Emmanouil Tsalamanios
BACKGROUND: Evidence suggests that many people with obsessive-compulsive disorder (OCD) have subclinical symptoms years before the development of their disorder and that early treatment may reduce its severity. AIM: To explore prevention and early intervention strategies for OCD. METHODS: A narrative literature review was conducted. RESULTS: The literature in relation to the prevention of OCD is sparse. Genetic and environmental factors appear to be relevant to the aetiology of OCD, for example, the observation that hoarding symptoms and contamination/cleaning symptoms are more likely to also be present in first-degree relatives...
December 14, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29234089/impact-of-treatment-on-resting-cerebral-blood-flow-and-metabolism-in-obsessive-compulsive-disorder-a-meta-analysis
#4
A L van der Straten, D Denys, G A van Wingen
Neurobiological models of obsessive-compulsive disorder (OCD) posit that its clinical symptoms such as repetitive thoughts and behaviors are related to hyperactivity in the cortico-striato-thalamo-cortical (CSTC) circuit. Small scale neuroimaging studies have shown that treatment of OCD is associated with reduced activity across different brain structures within this circuitry. We performed the first meta-analysis of positron emission tomography (PET) and single photon emission computed tomography (SPECT) studies that investigated cerebral blood flow or glucose metabolism in patients with OCD before and after pharmacological or psychological treatment...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29229708/neuronal-glutamate-transporters-control-dopaminergic-signaling-and-compulsive-behaviors
#5
Stefania Bellini, Kelsey E Fleming, Modhurika De, John P McCauley, Maurice A Petroccione, Lianna Y D'Brant, Artem Katchenko, SoYoung Kwon, Lindsey A Jones, Annalisa Scimemi
There is an ongoing debate on the contribution of the neuronal glutamate transporter EAAC1 to the onset of compulsive behaviors. Here we use behavioral, electrophysiological, molecular and viral approaches in male and female mice to identify the molecular and cellular mechanisms by which EAAC1 controls the execution of repeated motor behaviors. Our findings show that in the striatum, a brain region implicated with movement execution, EAAC1 limits group I metabotropic glutamate receptor (mGluRI) activation, facilitates D1 dopamine receptor (D1R) expression and ensures long-term synaptic plasticity...
December 11, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29227895/patients-with-ocd-report-lower-quality-of-life-after-controlling-for-expert-rated-symptoms-of-depression-and-anxiety
#6
Leila Jahangard, Vahid Fadaei, Arezoo Sajadi, Mohammad Haghighi, Mohammad Ahmadpanah, Nasrin Matinnia, Hafez Bajoghli, Dena Sadeghi Bahmani, Undine Lang, Edith Holsboer-Trachsler, Serge Brand
BACKGROUND: One to three percent of the adult population suffers from obsessive-compulsive disorders (OCD). Previous studies have also shown that, compared to controls, patients with OCD report a lower QoL. The latter is associated with self-rated symptoms of depression and anxiety. The aim of the present study was to compare the quality of life of OCD patients with that of healthy controls, while introducing expert-rated symptoms of depression and anxiety as covariates. Gender was also taken into account as an additional associated factor...
December 2, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29226166/a-radiographic-healing-classification-for-osteochondritis-dissecans-of-the-knee-provides-good-interobserver-reliability
#7
David E Ramski, Theodore J Ganley, James L Carey
Background: Recent studies have examined radiographic factors associated with healing of osteochondritis dissecans (OCD) lesions of the knee. However, there is still no gold standard in determining the healing status of an OCD lesion. Purpose: We examined temporally associated patterns of healing to (1) evaluate the practicality of a classification system and (2) elucidate any associations between healing pattern and patient age, sex, lesion location, treatment type, and physeal patency...
December 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29225044/fear-extinction-in-an-obsessive-compulsive-disorder-animal-model-influence-of-sex-and-estrous-cycle
#8
Adriano Edgar Reimer, Amanda Ribeiro de Oliveira, Juliana Belo Diniz, Marcelo Queiroz Hoexter, Euripedes Constantino Miguel, Mohammed Ragib Milad, Marcus Lira Brandão
Obsessive-compulsive disorder (OCD) is a neuropsychiatric condition that affects men and women equally, but with a sexually dimorphic pattern of development. Reproductive cycle events can influence symptom severity of OCD in females, indicating that ovarian hormones or their interaction with distinct neurotransmitter systems may play a role in OCD pathophysiology. Clinical studies and animal models have confirmed the importance of the serotonergic (5-HT) system in the neurobiology and treatment of OCD. Accordingly, the non-selective 5-HT2c agonist, meta-chlorophenylpiperazine (mCPP), exacerbates symptoms in untreated OCD patients...
December 7, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29220520/gaps-in-workplace-education-for-prevention-of-occupational-skin-disease
#9
Tanya Gupta, Victoria H Arrandale, Irena Kudla, D Linn Holness
Background: Occupational contact dermatitis (OCD) is a common occupational disease. Evidence suggests that education and training are effective prevention strategies. In spite of these known prevention strategies, workers continue to develop OCD. Little is reported regarding the actual training experience of workers. Objective: To examine the training experience of workers with contact dermatitis to identify areas for improvement. Methods: Participants were workers being assessed for contact dermatitis in an occupational health clinic...
December 5, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/29217994/local-fields-in-human-subthalamic-nucleus-track-the-lead-up-to-impulsive-choices
#10
John M Pearson, Patrick T Hickey, Shivanand P Lad, Michael L Platt, Dennis A Turner
The ability to adaptively minimize not only motor but cognitive symptoms of neurological diseases, such as Parkinson's Disease (PD) and obsessive-compulsive disorder (OCD), is a primary goal of next-generation deep brain stimulation (DBS) devices. On the basis of studies demonstrating a link between beta-band synchronization and severity of motor symptoms in PD, the minimization of beta band activity has been proposed as a potential training target for closed-loop DBS. At present, no comparable signal is known for the impulsive side effects of PD, though multiple studies have implicated theta band activity within the subthalamic nucleus (STN), the site of DBS treatment, in processes of conflict monitoring and countermanding...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29214602/peromyscus-maniculatus-bairdii-as-a-naturalistic-mammalian-model-of-obsessive-compulsive-disorder-current-status-and-future-challenges
#11
De Wet Wolmarans, Isabella M Scheepers, Dan J Stein, Brian H Harvey
Obsessive-compulsive disorder (OCD) is a prevalent and debilitating condition, characterized by intrusive thoughts and repetitive behavior. Animal models of OCD arguably have the potential to contribute to our understanding of the condition. Deer mice (Permomyscus maniculatus bairdii) are characterized by stereotypic behavior which is reminiscent of OCD symptomology, and which may serve as a naturalistic animal model of this disorder. Moreover, a range of deer mouse repetitive behaviors may be representative of different compulsive-like phenotypes...
December 6, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29210107/higher-serotonin-transporter-availability-in-early-onset-obsessive-compulsive-disorder-patients-undergoing-escitalopram-treatment-a-11-c-dasb-pet-study
#12
Junhee Lee, Bo-Hyung Kim, Euitae Kim, Oliver D Howes, Kang Ik Kevin Cho, Youngwoo Bryan Yoon, Jun Soo Kwon
OBJECTIVE: Early-onset obsessive-compulsive disorder (EOCD) and late-onset obsessive-compulsive disorder (LOCD) are distinct subtypes of obsessive-compulsive disorder (OCD). OCD patients are treated with serotonin reuptake inhibitors, but the difference in serotonin transporter (SERT) availability between medicated EOCD and LOCD is unexplored yet. METHODS: Six EOCD and 6 LOCD patients were enrolled. They underwent serial [11 C]DASB positron emission tomography scans during maintenance therapy with escitalopram, and their plasma concentration of escitalopram was measured simultaneously with the scan...
December 6, 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/29210084/comparison-of-sonography-and-mri-in-the-evaluation-of-stability-of-capitellar-osteochondritis-dissecans
#13
Masaaki Yoshizuka, Toru Sunagawa, Yuko Nakashima, Rikuo Shinomiya, Tetsuo Masuda, Manami Makitsubo, Nobuo Adachi
PURPOSE: To compare the diagnostic accuracies of ultrasonography (US) and magnetic resonance imaging (MRI) with intraoperative capitellar osteochondritis dissecans (COCD) fragment stability findings. METHODS: Patients whose International Cartilage Repair Society (ICRS) osteochondritis dissecans (OCD) classifications were I/II (stable) or III (unstable) were included. Patients underwent preoperative US and MRI. On US, lesions were evaluated as unstable when irregular contours of the chondral surface were observed...
December 6, 2017: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/29208201/-osteochondritis-dissecans
#14
Per Gorm Jørgensen, Per Hölmich
Osteochondritis dissecans (OCD) has been known for more than 100 years. Several reasons have been suggested as the major cause for developing OCD: trauma/microtrauma, ischaemic or genetic reasons. OCD is primarily located in the knee. In adolescent patients with knee symptoms, X-ray of the affected knee and often a subsequent MRI scan is indicated. Depending on the findings, an arthroscopy can be performed. Conservative treatment can be quiet regime or bracing. Operative treatment can be transchondral/retrograde drilling for the in situ lesion or fixation of the unstable lesion...
November 27, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29201116/fluoxetine-regulates-ig-kappa-chain-c-region-expression-levels-in-the-serum-of-obsessive-compulsive-disorder-patients-a-proteomic-approach
#15
Mona Zamanian Azodi, Mostafa Rezaei Tavirani, Afsaneh Arefi Oskouie, Mostafa Hamdieh, Mohammad Kamran Derakhshan, Alireza Ahmadzadeh, Farid Zayeri, Naser Nejadi, Majid Rezaei Tavirani, Vahid Mansouri, Mohammad Rostami-Nejad, Reza Vafaee
Obsessive-Compulsive Disorder (OCD) is one of the most common mental conditions. Proteome profiling may help identifying important proteins and finally shed lights to complexity of OCD underlying mechanisms. Here, by the application gel-based proteomic approach the proteome profile of patients with washing subtype of OCD before and after treatment with Fluoxetine (positive responders) are compared to healthy matched controls. However, only one of the differentially expressed proteins is examined and introduced in this paper...
2017: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29200551/efficacy-of-transcranial-direct-current-stimulation-in-the-treatment-resistant-patients-who-suffer-from-severe-obsessive-compulsive-disorder
#16
Kiomars Najafi, Youssef Fakour, Homa Zarrabi, Abtin Heidarzadeh, Mohammadrasoul Khalkhali, Taiebeh Yeganeh, Hasan Farahi, Marziyeh Rostamkhani, Tahereh Najafi, Soheil Shabafroz, Mahdiyeh Pakdaman
Background: During the past years, significant efforts have been made to explain the biological backgrounds of obsessive-compulsive disorder (OCD). Cortical-subcortical and neurotransmitter models are used for explaining the symptoms of OCD, so our hypothesis is that brain's transcranial direct current stimulation (TDCS) can regulate the brain activities of the OCD patients. Thus, based on the mentioned issues, this research seeks to investigate the efficacy of TDCS in treatment-resistant patients who suffer from severe OCD...
September 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/29197711/prevalence-of-sleep-disorders-and-severity-of-insomnia-in-psychiatric-outpatients-attending-a-tertiary-level-mental-health-care-facility-in-punjab-india
#17
Gargi Mondal, Vikrant Bajaj, B L Goyal, Nirmalya Mukherjee
BACKGROUND: Sleep disorders are frequently associated with psychiatric disorders and can be both cause and effect of the same. AIM: To study the prevalence of sleep disorders and the severity of insomnia in psychiatric outpatients. METHODS: 500 patients were randomly selected using purposive sampling from patients attending a tertiary level mental health care facility were evaluated for the presence of any sleep disorder along with their sleep quality...
November 27, 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29197636/osteochondritis-dissecans-of-the-knee
#18
REVIEW
F Accadbled, J Vial, J Sales de Gauzy
Osteochondritis dissecans (OCD) of the knee is an idiopathic, focal, subchondral-bone abnormality that can cause instability or detachment of a bone fragment and overlying articular cartilage, with subsequent progression to osteoarthritis. The diagnosis is usually made during adolescence. Mechanical factors play a major role in the pathophysiology of OCD. When the radiographic diagnosis is made early in a patient with open physes, healing can often be obtained simply by restricting sports activities. The degree of lesion instability can be assessed by magnetic resonance imaging...
November 29, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29195104/initial-psychometrics-outcomes-and-correlates-of-the-repetitive-body-focused-behavior-scale-examination-in-a-sample-of-youth-with-anxiety-and-or-obsessive-compulsive-disorder
#19
Robert R Selles, Valérie La Buissonnière Ariza, Nicole M McBride, Julie Dammann, Stephen Whiteside, Eric A Storch
BACKGROUND: Body-Focused Repetitive Behaviors (BFRBs), including skin-picking, hair-pulling, and nail-biting, commonly occur in youth, even at elevated/problematic levels, and are associated with a number of other psychiatric symptoms. The present study examined the internal consistency of a brief screening tool for BFRBs as well as the prevalence, severity, and correlates of BFRBs in a sample of youth with a primary anxiety or obsessive-compulsive disorder (OCD). METHODS: Ninety-three youth-parent dyads presenting for treatment for anxiety or OCD completed study measures including the Repetitive Body Focused Behavior Scale - Parent (RBFBS), which includes subscales for skin-picking, hair-pulling, and nail-biting, as well as a number of additional clinician-, parent-, and child-rated scales...
November 7, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29189538/what-s-new-in-pediatric-sports-conditions-of-the-knee
#20
Aristides I Cruz, Connor G Richmond, Marc A Tompkins, Ann Heyer, Kevin G Shea, Jennifer J Beck
BACKGROUND: Sports injuries are common in pediatric and adolescent patients and the evaluation and treatment of these injuries continues to evolve. The purpose of this review is to provide a comprehensive appraisal of the literature, highlighting recent updates on sports-related knee injuries in the pediatric athlete. We specifically examined literature on tibial spine fractures, osteochondritis dissecans (OCD) of the knee, and patellar instability. Because of the volume of literature on the subject, pediatric, and adolescent anterior cruciate ligament injuries were not included in this review...
November 16, 2017: Journal of Pediatric Orthopedics
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