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glucagonoma pathology

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https://www.readbyqxmd.com/read/27863775/operation-for-insulinomas-in-multiple-endocrine-neoplasia-type-1-when-pancreatoduodenectomy-is-appropriate
#1
Francesco Tonelli, Francesco Giudici, Gabriella Nesi, Giacomo Batignani, Maria Luisa Brandi
BACKGROUND: Distal pancreatectomy is the most frequent operation for insulinomas complicating multiple endocrine neoplasia type 1 insulinoma, although there are conditions for which a different operative approach might be preferable. In this article, we report the operative experience of a referral center for multiple endocrine neoplasia type 1 insulinoma. METHODS: Twelve patients underwent operations between 1992 and 2015: 8 underwent a distal pancreatic resection, and 4 underwent a pancreatoduodenectomy...
November 15, 2016: Surgery
https://www.readbyqxmd.com/read/26657531/metastatic-vipoma-presenting-as-an-ovarian-mass
#2
Jaron Mark, Stephen Bush, Evan Glazer, Jonathan Strosberg, Ozlen Saglam, Sachin M Apte
INTRODUCTION: Pancreatic VIPomas are exceedingly rare, with an annual incidence of less than 1 per million. Most VIPomas are metastatic at diagnosis, with the liver being the most common site of spread. PRESENTATION OF CASE: We describe a highly unusual case of a metastatic pancreatic VIPoma to an ovary in a 54 year-old patient. She was ten years out from her initial diagnosis when routine CT scan showed an enlarging left adnexal mass. After having both ovaries removed laparoscopically the final pathology was consistent with her pancreatic primary...
2015: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/25914784/glucagon-receptor-gene-mutations-with-hyperglucagonemia-but-without-the-glucagonoma-syndrome
#3
Helen C Miller, Mark Kidd, Irvin M Modlin, Patrizia Cohen, Roberto Dina, Panagiotis Drymousis, Panagiotis Vlavianos, Günter Klöppel, Andrea Frilling
Pancreatic neoplasms producing exclusively glucagon associated with glucagon cell hyperplasia of the islets and not related to hereditary endocrine syndromes have been recently described. They represent a novel entity within the panel of non-syndromic disorders associated with hyperglucagonemia. This case report describes a 36-year-old female with a 10 years history of non-specific abdominal pain. No underlying cause was evident despite extensive diagnostic work-up. More recently she was diagnosed with gall bladder stones...
April 27, 2015: World Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/25373364/non-secreting-benign-glucagonoma-diagnosed-incidentally-in-a-patient-with-refractory-thrombocytopenic-thrombotic-purpura-report-of-a-case
#4
Georgios K Georgiou, Ioannis Gizas, Konstantinos P Katopodis, Christos S Katsios
Thrombotic thrombocytopenic purpura (TTP) is a rare hematologic disorder, which may be idiopathic or secondary to a variety of diseases. However, there are very few reports of TTP in the context of pancreatic neoplasms. We report a case of relapsing TTP after initial treatment with plasmapheresis, corticosteroids, and rituximab, in a 59-year-old woman. During diagnostic work-up, a pancreatic lesion 35 × 25 mm in size was discovered incidentally and splenopancreatectomy was performed. The pathological diagnosis was benign glucagonoma...
October 2015: Surgery Today
https://www.readbyqxmd.com/read/24755752/-a-case-of-alpha-cell-nesidioblastosis-and-hyperplasia-with-multiple-glucagon-producing-endocrine-cell-tumor-of-the-pancreas
#5
Huapyong Kang, Sewha Kim, Tae Seop Lim, Hye Won Lee, Heun Choi, Chang Moo Kang, Ho Guen Kim, Seungmin Bang
Nesidioblastosis is a term used to describe pathologic overgrowth of pancreatic islet cells. It also means maldistribution of islet cells within the ductules of exocrine pancreas. Generally, nesidioblastosis occurs in beta-cell and causes neonatal hyperinsulinemic hypoglycemia or adult noninsulinoma pancreatogenous hypoglycemia syndrome. Alpha-cell nesidioblastosis and hyperplasia is an extremely rare disorder. It often accompanies glucagon-producing marco- and mircoadenoma without typical glucagonoma syndrome...
April 2014: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/24285676/pancreatic-%C3%AE-cell-hyperplasia-facts-and-myths
#6
REVIEW
Run Yu
CONTEXT: Pancreatic α-cell hyperplasia (ACH) was once an esoteric pathological entity, but it has become an important differential diagnosis of hyperglucagonemia after inactivating glucagon receptor (GCGR) genomic mutations were found in patients with ACH. Recently, the controversy over the pancreatic effects of incretins has stimulated much discussion of ACH that often includes inaccurate statements not supported by the literature. DATA ACQUISITION: Literature related to ACH was reviewed...
March 2014: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/24018597/pancreatic-glucagonoma-metastasising-to-the-right-ovary-five-years-after-initial-surgery-a-case-report
#7
David Graham Watt, Sanjay Pandanaboyana, Charles Simon Herrington, Iain S Tait
CONTEXT: Glucagonomas of the pancreas are neuroendocrine tumours (NETs) that arise from well-differentiated neuroendocrine cells within the pancreatic islets. They are considered to be aggressive NETs and often have metastases at initial presentation. In contrast localised glucagonoma without metastatic spread may have prolonged disease free survival with radical resectional surgery. CASE REPORT: The authors present a case of a glucagonoma that initially presented with classical necrolytic migratory erythema and a large solitary mass in the body and tail of the pancreas that was surgically resected...
September 2013: JOP: Journal of the Pancreas
https://www.readbyqxmd.com/read/23644134/-diagnosis-and-treatment-of-glucagonoma-report-of-one-case
#8
Hong Cheng, Maoshan Chen, Guanglun Yang
glucagonoma is a rare islet alpha-cell tumor. We report a case of glucagonoma in a 55-year-old male patient with such clinical findings of necrolytic migratory erythema, diabetes mellitus, body weight loss, and anemia. CT examination found a space-occupying lesion in the pancreas, and an elevated serum glucagon level indicate the diagnosis of glucagonoma, which was confirmed postoperatively by pathological examination of the tumor tissue. A definite diagnosis of glucagonoma relies on pathological report, and so far no standard treatment strategy has been available for this tumor...
April 2013: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/23167375/role-of-endoscopic-ultrasound-in-evaluation-of-pancreatic-neuroendocrine-tumors-report-of-22-cases-from-a-tertiary-center-in-iran
#9
Shirin Haghighi, Mahsa Molaei, Forough Foroughi, Mojgan Foroutan, Reza Dabiri, Effat Habibi, Amir Houshang Mohammad Alizadeh
BACKGROUND: The pancreatic neuroendocrine tumor (pNET) is relatively rare and generally felt to follow an indolent course. EUS has an important role in detection of pNET. This is a review of clinical and radiological presentation and pathologic reports of 22 patients with pNET. PATIENTS AND METHODS: In this study we analyzed clinical and radiological presentations and pathologic reports of all relevant cases who were referred to Taleghani hospital for 3 years since 2008...
2012: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/23084041/asymptomatic-insulinoma-a-case-report-and-autopsy-series
#10
Satoru Kishi, Kentaro Sakamoto, Masaya Mori, Akihiro Isogawa, Teruo Shiba
AIMS: We investigated the prevalence and characterization of asymptomatic pancreatic tumors in response to our experience of asymptomatic insulinoma. METHODS: A patient with a moderately low glucose level and pancreatic incidentaloma detected by CT was examined. Pancreas specimens from 423 autopsy cases were also pathologically examined systematically by hematoxylin-eosin staining. RESULTS: The examined patient showed no profile characteristic of insulinoma by fasting or loading tests, however, ASVS led to diagnosis of insulin-producing tumor...
December 2012: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/22968429/vascular-pancreatic-lesions-spectrum-of-imaging-findings-of-malignant-masses-and-mimics-with-pathologic-correlation
#11
REVIEW
Priya R Bhosale, Christine O Menias, Aparna Balachandran, Eric P Tamm, Chusilp Charnsangavej, Isaac R Francis, Khaled M Elsayes
The differential diagnosis of hypervascular pancreatic lesions is complex, and includes endocrine and exocrine tumors of the pancreas, metastases to the pancreas, and masses, or mass-like lesions, arising from the neurovascular networks traversing the pancreas. In this manuscript, we will discuss salient imaging findings of these masses, pertinent differential diagnoses, as well as review clinical symptomatology that may aid in the diagnosis of some of these lesions.
August 2013: Abdominal Imaging
https://www.readbyqxmd.com/read/21853126/pancreatic-neuroendocrine-tumors-in-glucagon-receptor-deficient-mice
#12
Run Yu, Deepti Dhall, Nicholas N Nissen, Cuiqi Zhou, Song-Guang Ren
Inhibition of glucagon signaling causes hyperglucagonemia and pancreatic α cell hyperplasia in mice. We have recently demonstrated that a patient with an inactivating glucagon receptor mutation (P86S) also exhibits hyperglucagonemia and pancreatic α cell hyperplasia but further develops pancreatic neuroendocrine tumors (PNETs). To test the hypothesis that defective glucagon signaling causes PNETs, we studied the pancreata of mice deficient in glucagon receptor (Gcgr(-/-)) from 2 to 12 months, using WT and heterozygous mice as controls...
2011: PloS One
https://www.readbyqxmd.com/read/21690450/pancreatic-endocrine-tumors-with-major-vascular-abutment-involvement-or-encasement-and-indication-for-resection
#13
Jeffrey A Norton, Edmund J Harris, Yijun Chen, Brendan C Visser, George A Poultsides, Pamela C Kunz, George A Fisher, Robert T Jensen
BACKGROUND: Surgery for pancreatic endocrine tumors (PETs) with blood vessel involvement is controversial. HYPOTHESIS: Resection of PETs with major blood vessel involvement can be beneficial. DESIGN: The combined databases of the National Institutes of Health and Stanford University hospitals were queried. MAIN OUTCOME MEASURES: Operation, pathologic condition, complications, and disease-free and overall survival. RESULTS: Of 273 patients with PETs, 46 (17%) had preoperative computed tomography evidence of major vascular involvement...
June 2011: Archives of Surgery
https://www.readbyqxmd.com/read/21245985/pathologic-pancreatic-endocrine-cell-hyperplasia
#14
REVIEW
Debra Ouyang, Deepti Dhall, Run Yu
Pathologic hyperplasia of various pancreatic endocrine cells is rare but has been long known. β cell hyperplasia contributes to persistent hyperinsulinemic hypoglycemia of infancy, which is commonly caused by mutations in the islet ATP-sensitive potassium channel, and to non-insulinoma pancreatogenous hypoglycemia in adults, which may or may not be associated with bariatric surgery. α cell hyperplasia may cause glucagonoma syndrome or induce pancreatic neuroendocrine tumors. An inactivating mutation of the glucagon receptor causes α cell hyperplasia and asymptomatic hyperglucagonemia...
January 14, 2011: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/21071369/pancreatic-endocrine-tumors-radiologic-clinicopathologic-correlation
#15
REVIEW
Rachel B Lewis, Grant E Lattin, Edina Paal
Pancreatic endocrine tumors (PETs) are primarily well-differentiated tumors composed of cells that resemble normal islet cells but that arise from pancreatic ductal cells. They are classified as functioning or nonfunctioning according to their associated clinical symptoms; insulinoma, gastrinoma, and glucagonoma are the most common functioning PETs. They also are classified according to their biologic behavior, although all PETs have malignant potential. Most are sporadic, but some are associated with familial syndromes such as multiple endocrine neoplasia type 1, von Hippel-Lindau syndrome, and neurofibromatosis type 1...
October 2010: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/20550685/duodenal-enteroglucagonoma-revealed-by-differential-comparison-of-serum-and-tissue-glucagon-reactivity-with-siemens-double-glucagon-antibody-and-dakocytomation-s-polyclonal-rabbit-anti-human-glucagon-a-case-report
#16
Wesley B Vanderlan, Ziying Zhang, Marwan S Abouljoud
INTRODUCTION: This case report demonstrates that the differential immunohistochemical reactivities of Siemens' Double Antibody Glucagon compared to DakoCytomation's Polyclonal Rabbit Anti-Human Glucagon allow for pathologic distinction of enteral versus pancreatic glucagonoma. CASE PRESENTATION: A 64-year-old Caucasian man was diagnosed with a duodenal enteroglucagonoma following presentation with obstructive jaundice. He had a low serum glucagon level using Siemens' Double Antibody Glucagon, a clinical syndrome consistent with glucagon hypersecretion...
2010: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/20530930/a-case-of-pancreatic-glucagonoma-with-erythema
#17
Michihiro Yoshida, Kazuki Hayashi, Hirotaka Ohara, Katsuyuki Miyabe, Fumihiro Okumura, Itaru Naitoh, Hajime Tanaka, Tomoaki Ando, Takahiro Nakazawa, Satoru Takahashi, Takashi Joh
A 38-year-old man was admitted because of exacerbation of erythema. Full-body computed tomography (CT) scanning revealed a tumor mass in the tail of the pancreas; CT and magnetic resonance imaging (MRI) scans confirmed the presence of a spherical mass. In contrast CT scans, although the contrast was gradually increased, no strong contrast differences were observed between the tumor and the surrounding tissue. Endoscopic ultrasonography (EUS) revealed a spherical low-density mass. Blood test results revealed that the patient had a high glucagon level...
June 2010: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/19819769/immunohistochemical-expression-of-somatostatin-receptors-in-digestive-endocrine-tumours
#18
MULTICENTER STUDY
V Zamora, A Cabanne, R Salanova, C Bestani, E Domenichini, F Marmissolle, N Giacomi, J O'Connor, G Méndez, E Roca et al.
INTRODUCTION: Somatostatin receptors are expressed in a large number of human tumours. The somatostatin receptors types 1-5 expression in a series including 100 gastro-entero-pancreatic endocrine tumours were analysed. METHODS: From a prospectively built database of patients with gastro-entero-pancreatic endocrine tumours referred from three institutions, 100 cases with clinical and pathological data were selected. Somatostatin receptors expression by immunohistochemistry with somatostatin receptor types 1-5 antibodies in tissue paraffin sections were studied and correlated with the histological diagnosis according to the WHO classification, location and functional status...
March 2010: Digestive and Liver Disease
https://www.readbyqxmd.com/read/19595005/-clinical-experience-in-diagnosis-and-treatment-of-glucagonoma
#19
Wen-jing Liu, Yu-pei Zhao, Tai-ping Zhang, Quan Liao, Lin Cong
OBJECTIVE: To study the diagnosis and treatment of glucagonoma. METHODS: A retrospective review of glucagonoma cases was committed between June 1993 and July 2008 in Peking Union Medical College Hospital. It was measured by sex, age, misdiagnosis, clinical symptoms, laboratory data, imaging studies, diagnosis, treatment procedures and so on. RESULTS: The tumors of eleven cases were found in the tail, and one case was in the head of the pancreas at the same time...
March 1, 2009: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/18501813/cystic-pancreatic-endocrine-neoplasms-a-distinct-tumor-type
#20
Liliana Bordeianou, Parsia A Vagefi, Dushyant Sahani, Vikram Deshpande, Elena Rakhlin, Andrew L Warshaw, Carlos Fernández-del Castillo
BACKGROUND: Cystic pancreatic endocrine neoplasms (CPENs) are considered rare, and their behavior is thought to be similar to that of solid pancreatic endocrine neoplasms (PENs). This study aims to describe the characteristics of CPENs in a large patient cohort. STUDY DESIGN: We performed a retrospective review of 170 patients who underwent resections for PENs at Massachusetts General Hospital from 1977 to 2006. Twenty-nine patients (51% men, mean age 53) with CPENs were compared with 141 patients with solid PENs...
June 2008: Journal of the American College of Surgeons
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