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https://www.readbyqxmd.com/read/29764220/wide-range-crp-versus-high-sensitivity-crp-on-roche-analyzers-focus-on-low-grade-inflammation-ranges-and-high-sensitivity-cardiac-troponin-t-levels
#1
Denis Monneret, Fouzi Mestari, Shaedah Djiavoudine, Guillaume Bachelot, Maxime Cloison, Françoise Imbert-Bismut, Maguy Bernard, Pierre Hausfater, Jean-Marc Lacorte, Dominique Bonnefont-Rousselot
Wide-range C-reactive protein (wr-CRP) has been proposed as an economical alternative to high-sensitivity C-reactive protein (hs-CRP) for the evaluation of low-grade inflammation-associated cardiovascular risk (LGI-CVR). Concomitant values of serum hs-CRP and plasma wr-CRP ≤5 mg/L, and high-sensitivity cardiac troponin T (hs-cTnT), all assayed on Roche Diagnostics analyzers over a 1.8-year period, were extracted from a hospital laboratory database. Hs-CRP and wr-CRP values were compared (Bland-Altman method; Deming's correlation), then separately classified into low (<1 mg/L), moderate (1-3 mg/L) and high (>3 mg/L) LGI-CVR ranges for agreement test (κ), assessed before and after Deming's regression-based adjustment of wr-CRP (Adj-wr-CRP)...
May 15, 2018: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29760312/change-in-cerebral-blood-flow-after-palliative-percutaneous-angioplasty-and-timing-of-second-stage-carotid-artery-stenting-in-staged-angioplasty
#2
Hisashi Nagashima, Kazuhiro Hongo, Alhusain Nagm
The purpose of this study is to elucidate the hemodynamic changes after palliative angioplasty and the timing of second stage carotid artery stenting (CAS) in staged angioplasty for patients with severe hemodynamically compromised carotid artery stenosis. Among consecutive 111 patients with carotid artery stenosis, chronological changes in the cerebral blood flow of all 11 hemodynamically compromised patients treated with CAS were evaluated with single photon emission computed tomogram (SPECT) in each stage of the treatment...
May 11, 2018: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/29751757/assessment-of-the-knowledge-and-attitude-of-infants-mothers-from-bushehr-iran-on-food-security-using-anthropometric-indicators-in-2016-a-cross-sectional-study
#3
Sedigheh Yeganeh, Niloofar Motamed, Saeid NajafpourBoushehri, Maryam Ravanipour
BACKGROUND: Among the main elements of food security, in terms of food usage, are knowledge and attitude. These are particularly important during the initial two years of a child's life. The present study was conducted in 2016 and aimed to assess the knowledge and attitude of infants' mothers from Bushehr (Iran) towards food security using anthropometric indicators. METHODS: The present cross-sectional, descriptive-analytical study was performed on 400 mothers of children aged 1-2 years in Bushehr, Iran...
May 11, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29739677/soy-isoflavones-improve-cardiovascular-disease-risk-markers-in-women-during-the-early-menopause
#4
T Sathyapalan, M Aye, A S Rigby, N J Thatcher, S R Dargham, E S Kilpatrick, S L Atkin
BACKGROUND: Hormone replacement therapy may be beneficial for cardiovascular disease risk (CVR) in post-menopausal women. Soy isoflavones may act as selective estrogen receptor modulators. The aim of this study was to evaluate whether soy isoflavones had an effect on CVR markers. METHODS: The expected 10-year risk of cardiovascular disease and mortality were calculated as a secondary endpoint from a double blind randomised parallel study involving 200 women (mean age 55 years, Caucasian, Hull, UK, 2012) in the early menopause who were randomised to 15 g soy protein with 66 mg isoflavone (SPI) or 15 g soy protein alone (depleted of all isoflavones; SP) given as a snack bar between meals daily for 6 months...
April 10, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29726891/understanding-the-role-of-the-perivascular-space-in-cerebral-small-vessel-disease
#5
Rosalind Brown, Helene Benveniste, Sandra E Black, Serge Charpak, Martin Dichgans, Anne Joutel, Maiken Nedergaard, Kenneth J Smith, Berislav V Zlokovic, Joanna M Wardlaw
Small vessel diseases are a group of disorders that result from pathological alteration of the small blood vessels in the brain, including the small arteries, capillaries and veins. Of the 35-36 million people that are estimated to suffer from dementia worldwide, up to 65% have an SVD component. Furthermore, SVD causes 20-25% of strokes, worsens outcome after stroke and is a leading cause of disability, cognitive impairment and poor mobility. Yet the underlying cause(s) of SVD are not fully understood.Magnetic resonance imaging (MRI) has confirmed enlarged perivascular spaces (PVS) as a hallmark feature of SVD...
May 2, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29725498/characterization-of-portuguese-centenarian-eating-habits-nutritional-biomarkers-and-cardiovascular-risk-a-case-control-study
#6
A Pereira da Silva, A Valente, C Chaves, A Matos, A Gil, A C Santos, J P Gorjão-Clara, M Bicho
Background and Aims: Eating habits may contribute to longevity. We characterized the eating habits and cardiovascular risk (CVR) biomarkers in Portuguese centenarians (CENT) compared to controls. Methods and Results: Centenarians ( n = 253), 100.26 ± 1.98 years, were compared with 268 controls (67.51 ± 3.25), low (LCR) and high (HCR) CVR (QRISK®2-2016). Anthropometric and body composition were evaluated by bioimpedance. Abdominal obesity, BMI, and fat mass (FM) cut-offs were according to the WHO...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29702200/long-term-neurological-and-neuropsychological-complications-of-sulfur-mustard-and-lewisite-mixture-poisoning-in-chinese-victims-exposed-to-chemical-warfare-agents-abandoned-at-the-end-of-wwii
#7
O Isono, A Kituda, M Fujii, T Yoshinaka, G Nakagawa, Y Suzuki
In August 2003, 44 victims were poisoned by chemical warfare agents (CWAs) leaked from five drums that were excavated at a construction site in Qiqihar, Northeast China. The drums were abandoned by the former Japanese imperial army during World War II and contained a mixture of Sulfur mustard (SM) and Lewisite. We carried out a total of six regular check-ups between 2006 and 2014, and from 2008 we added neurological evaluations including neuropsychological test and autonomic nervous function test in parallel with medical follow-up as much as was possible...
April 24, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29694543/a-framework-to-assess-management-performance-in-district-health-systems-a-qualitative-and-quantitative-case-study-in-iran
#8
Jafar Sadegh Tabrizi, Kamal Gholipour, Shabnam Iezadi, Mostafa Farahbakhsh, Akbar Ghiasi
The aim was to design a district health management performance framework for Iran's healthcare system. The mixed-method study was conducted between September 2015 and May 2016 in Tabriz, Iran. In this study, the indicators of district health management performance were obtained by analyzing the 45 semi-structured surveys of experts in the public health system. Content validity of performance indicators which were generated in qualitative part were reviewed and confirmed based on content validity index (CVI)...
2018: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/29687019/phosphodiesterase-5-inhibition-potentiates-cerebrovascular-reactivity-in-chronic-traumatic-brain-injury
#9
Kimbra Kenney, Franck Amyot, Carol Moore, Margalit Haber, L Christine Turtzo, Christian Shenouda, Erika Silverman, Yunhua Gong, Bao-Xi Qu, Leah Harburg, Eric M Wassermann, Hanzhang Lu, Ramon Diaz-Arrastia
Background: Traumatic cerebrovascular injury (TCVI), a common consequence of traumatic brain injury (TBI), presents an attractive therapeutic target. Because phosphodiesterase-5 (PDE5) inhibitors potentiate the action of nitric oxide (NO) produced by endothelial cells, they are candidate therapies for TCVI. This study aims to: (1) measure cerebral blood flow (CBF), cerebrovascular reactivity (CVR), and change in CVR after a single dose of sildenafil (ΔCVR) in chronic TBI compared to uninjured controls; (2) examine the safety and tolerability of 8-week sildenafil administration in chronic symptomatic moderate/severe TBI patients; and as an exploratory aim, (3) assess the effect of an 8-week course of sildenafil on chronic TBI symptoms...
April 2018: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29685407/staged-carotid-artery-stenting-in-patients-with-severe-carotid-stenosis-multicenter-experience
#10
Dong Hyun Yoo, Hong Gee Roh, See-Sung Choi, Jusun Moon, Jeongjun Lee, Young Dae Cho, Moon Hee Han, Keun-Hwa Jung, Byung-Woo Yoon, Hyun-Seung Kang
Cerebral hyperperfusion syndrome (CHS) is serious complication after carotid artery stenting (CAS) caused by decreased cerebral vasoreactivity (CVR) due to long standing hypoperfusion of the brain. We hypothesized that partial dilatation of carotid stenosis would allow the recovery of CVR, and prevent CHS when definitive angioplasty with stent is performed afterward. In this study, we aimed to evaluate the safety and efficacy of staged CAS in patients with severe carotid artery stenosis with evident hemodynamic compromise in regard to preventing hyperperfusion syndrome...
April 20, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29681886/importance-of-collateralization-in-patients-with-large-artery-intracranial-occlusive-disease-long-term-longitudinal-assessment-of-cerebral-hemodynamic-function
#11
Larissa McKetton, Lakshmikumar Venkatraghavan, Julien Poublanc, Olivia Sobczyk, Adrian P Crawley, Casey Rosen, Frank L Silver, James Duffin, Joseph A Fisher, David J Mikulis
Patients with large artery intracranial occlusive disease (LAICOD) are at risk for both acute ischemia and chronic hypoperfusion. Collateral circulation plays an important role in prognosis, and imaging plays an essential role in diagnosis, treatment planning, and prognosis of patients with LAICOD. In addition to standard structural imaging, assessment of cerebral hemodynamic function is important to determine the adequacy of collateral supply. Among the currently available methods of assessment of cerebral hemodynamic function, measurement of cerebrovascular reactivity (CVR) using blood oxygen level-dependent (BOLD) MRI and precisely controlled CO2 has shown to be a safe, reliable, reproducible, and clinically useful method for long-term assessment of patients...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29665020/type-ii-and-iii-congenital-pulmonary-airway-malformation-with-hydrops-treated-in-utero-with-percutaneous-sclerotherapy
#12
Andrew H Chon, Lisa M Korst, Mira Abdel-Sattar, Arlyn Llanes, Joseph G Ouzounian, Ramen H Chmait
OBJECTIVE: To present outcomes of fetuses with congenital pulmonary airway malformation (CPAM) treated with sclerotherapy. METHODS: Retrospective study of 8 patients with a prenatal diagnosis of CPAM type II or III with secondary hydrops treated with percutaneous sclerotherapy using 5% ethanolamine oleate (EO). All patients underwent ultrasonic measurement of the CPAM volume ratio (CVR). Results are expressed as median (range). RESULTS: Gestational age (GA) at initial sclerotherapy was 22...
April 17, 2018: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29649969/magnetic-resonance-imaging-for-assessment-of-cerebrovascular-reactivity-and-its-relationship-to-cognition-a-systematic-review
#13
Sarah J Catchlove, Andrew Pipingas, Matthew E Hughes, Helen Macpherson
BACKGROUND: Cerebrovascular reactivity (CVR) refers to the responsiveness of cerebral vasculature to vasoactive stimuli. CVR is an indicator of brain health and can be assessed using vasodilatory techniques and magnetic resonance imaging (MRI). Using such approaches, some researchers have explored the relationship between CVR and cognition; here we systematically review this work. RESULTS: We extracted information pertaining to: (1) study location and design, participant characteristics, sample sizes, (2) design of vascular challenge, end-tidal CO 2 (etCO 2 ) concentrations (if applicable), (3) MRI protocol, (4) cognitive assessment, (5) CVR values, and outcomes of statistical analyses with cognitive tests...
April 12, 2018: BMC Neuroscience
https://www.readbyqxmd.com/read/29611400/real-world-experience-of-telbivudine-versus-entecavir-in-patients-with-chronic-hepatitis-b-including-long-term-outcomes-after-treatment-modification
#14
Jong Won Choi, Se Hyun Kim, Jeong Hun Seo, Yong Suk Cho, Sun Young Won, Byung Kyu Park, Han Ho Jeon, Yong Kang Lee, Chun Kyon Lee
PURPOSE: To estimate long-term outcomes after treatment modification in patients with chronic hepatitis B (CHB) treated with entecavir (ETV) and telbivudine (LdT). MATERIALS AND METHODS: The study enrolled 131 nucleos(t)ide analogue (NA)-naïve CHB patients treated with ETV or LdT. During the 3-year study, NA treatment history including the incidence, the type of treatment modification, reasons for the modification, and overall complete virologic response (CVR) rate were retrospectively evaluated using the patients' medical records...
May 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29609518/vascular-abnormalities-within-normal-appearing-tissue-in-chronic-traumatic-brain-injury
#15
Margalit Haber, Franck Amyot, Kimbra Kenney, Tawny Meredith-Duliba, Carol Moore, Erika Silverman, Jamie Podell, Yi-Yu Chou, Dzung L Pham, John Butman, Hanzang Lu, Ramon Diaz-Arrastia, Danielle Sandsmark
Magnetic resonance imaging (MRI) is a powerful tool for visualizing traumatic brain injury(TBI)-related lesions. Trauma-induced encephalomalacia is frequently identified by its hyperintense appearance on fluid-attenuated inversion recovery (FLAIR) sequences. In addition to parenchymal lesions, TBI commonly results in cerebral microvascular injury, but its anatomic relationship to parenchymal encephalomalacia is not well characterized. The current study utilized a multimodal MRI protocol to assess microstructural tissue integrity [via mean diffusivity (MD) and fractional aniosotropy (FA)], and altered vascular function [via cerebral blood flow (CBF) and cerebral vascular reactivity (CVR)], within regions of visible encephalomalacia and normal appearing tissue in 27 chronic TBI (minimum 6 months after injury) subjects...
April 2, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29606610/evaluation-of-methods-used-for-estimating-content-validity
#16
Enas Almanasreh, Rebekah Moles, Timothy F Chen
The assessment of content validity is a critical and complex step in the development process of instruments which are frequently used to measure complex constructs in social and administrative pharmacy research. The aims of this study were to investigate the elements of content validity; to describe a practical approach for assessing content validity; and to discuss existing content validity indices. This is a narrative review of the assessment and quantification of content validity. It describes the key stages of conducting the content validation study and discusses the quantification and evaluation of the content validity estimates...
March 27, 2018: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/29604511/a-bacterium-based-contact-assay-for-evaluating-the-quality-of-solid-samples-results-from-an-international-ring-test
#17
Catarina R Marques, Najoi El-Azhari, Fabrice Martin-Laurent, Pascal Pandard, Camille Meline, Alice L Petre, Suzanne Eckert, Jürgen Zipperle, Martin Váňa, Stanislav Maly, Lucie Šindelářová, Anna Slavíková Amemori, Jakub Hofman, Anu Kumar, Hai Doan, Mike McLaughlin, Elizabeth Richter, Jörg Römbke
The contact assay measuring the inhibition of Arthrobacter globiformis dehydrogenase activity as an endpoint to evaluate the toxicity of solid samples was tested in an international ring-test to validate its performance for ISO standardization (ISO/CD 18187). This work reports the results of the ring-test involving 9 laboratories from six countries. At least 8 valid data sets were obtained for each sample and more than three quarters of the participants attained the validity criteria defined in the standard...
March 20, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29598865/pet-assessment-of-epicardial-intimal-disease-and-microvascular-dysfunction-in-cardiac-allograft-vasculopathy
#18
Sharon Chih, Aun Yeong Chong, Fernanda Erthal, Robert A deKemp, Ross A Davies, Ellamae Stadnick, Derek Y So, Christopher Overgaard, George Wells, Lisa M Mielniczuk, Rob S B Beanlands
BACKGROUND: Cardiac allograft vasculopathy (CAV) is a leading cause of graft failure and death after heart transplantation. Absolute myocardial blood flow (MBF) quantification using rubidium 82 (Rb-82) positron emission tomography (PET) could enable evaluation of diagnostically challenging diffuse epicardial and microvascular disease in CAV. OBJECTIVES: The authors aimed to evaluate Rb-82 PET detection of CAV. METHODS: Consecutive transplant recipients undergoing coronary angiography were prospectively evaluated with PET, multivessel intravascular ultrasound (IVUS), and intracoronary hemodynamics...
April 3, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29596483/development-of-post-disaster-psychosocial-evaluation-and-intervention-for-children-results-of-a-south-korean-delphi-panel-survey
#19
Mi-Sun Lee, Jun-Won Hwang, Cheol-Soon Lee, Ji-Youn Kim, Ju-Hyun Lee, Eunji Kim, Hyoung Yoon Chang, SeungMin Bae, Jang-Ho Park, Soo-Young Bhang
OBJECTIVE: This study aimed to administer a Delphi panel survey and provide evidence for the development of a psychological intervention protocol for use after disasters in South Korea. METHOD: A three-round Delphi survey was conducted. In all rounds, respondents answered open- or closed-ended questions regarding their views on i) the concept of disaster, ii) evaluation, iii) intervention, and iv) considerations in a disaster. Data from Round 1 were subjected to content analysis...
2018: PloS One
https://www.readbyqxmd.com/read/29594076/translation-cross-cultural-adaptation-validation-and-reliability-of-the-northwestern-dysphagia-patient-check-sheet-ndpcs-in-iran
#20
Jalal Bakhtiyari, Masoomeh Salmani, Reyhaneh Noruzi, Payam Sarraf, Ebrahim Barzegar, Majid Mirmohammadkhani
Introduction: Speech and language therapists (SLTs) require proper tools to detect dysphagia in the early stages. One of these screening tools is the Northwestern Dysphagia Patient Check Sheet (NDPCS). However, this tool needs to be adapted, validated, and shown to be reliable for the Persian culture. The aim of the present study was to report the validity and reliability of the Persian NDPCS (P-NDPCS). Materials and Methods: The NDPCS has 28 items and five sections...
March 2018: Iranian Journal of Otorhinolaryngology
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