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recent advances in management of transient ischemic attacks and minor ischemic strokes

Philippe Lavallée, Pierre Amarenco
Transient ischemic attack (TIA) is the most important risk factor for ischemic stroke. The risk is the highest in the first hours after symptom onset, and treatment must be initiated in emergency. In the acute phase, antithrombotic agent is probably the most important treatment, but it is not excluded that lipid-lowering agents and/or antihypertensive drugs are also important. For current guidelines, monotherapy of antiplatelet agent remains the gold standard in emergency. However, most recent data and meta-analysis support a combination therapy of clopidogrel and aspirin...
2014: Frontiers of Neurology and Neuroscience
Peter M Rothwell, Alastair Buchan, S Claiborne Johnston
The risk of recurrent stroke during the first few days after a transient ischaemic attack or minor stroke is much higher than previously estimated. However, there is substantial variation worldwide in how patients with suspected transient ischaemic attack or minor stroke are investigated and treated in the acute phase: some health-care systems provide immediate emergency inpatient care and others provide non-emergency outpatient clinical assessment. This review considers what is known about the early prognosis after transient ischaemic attack and minor ischaemic stroke, what factors identify individuals at particularly high early risk of stroke, and what evidence there is that urgent preventive treatment is likely to be effective in reducing the early risk of stroke...
April 2006: Lancet Neurology
Mark K Eskandari, G Matthew Longo, Jon S Matsumura, Melina R Kibbe, Mark D Morasch, Kelley R Cardeira, William H Pearce
BACKGROUND: Percutaneous CAS may well replace CEA as standard of care. CAS has been performed largely by interventional cardiologists; however, with recent Food and Drug Administration approval, vascular surgeons are now hurriedly attempting to obtain the requisite endovascular skills. Reported are our 30-day and midterm outcomes of CAS. METHODS: Retrospective review of 175 cervical carotid stenoses treated with elective CAS from April 2001 to February 2005. All procedures were performed under local anesthesia via percutaneous femoral access in an operating room angiosuite...
September 2005: Annals of Surgery
P Sandercock
Appropriate management of the patient with transient focal neurological symptoms must start with accurate clinical diagnosis. Wider use of clear diagnostic criteria and symptom checklists, and better knowledge of the clinical features of the 'funny turns' which are not related to transient focal cerebral ischaemia could reduce the present variability in clinical diagnosis of transient ischaemic attacks. More accurate clinical diagnosis contributes to better selection of the most appropriate investigation strategy for each patient...
February 1991: Quarterly Journal of Medicine
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