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Catherine Masiel Merejo Peña, Michel Silva Reis, Basílio de Bragança Pereira, Emília Matos do Nascimento, Roberto Coury Pedrosa
BACKGROUND: It has been difficult to prove that "catecholamine-induced cardiomyopathy" contributes to the mechanism of sudden cardiac death in Chagas heart disease. Also, it is almost impossible to rule out the possibility that it is not involved in the process. More importantly, the vagal-cholinergic pathway in the ventricle plays a direct role in the prevention of the initiation of complex ventricular arrhythmias, including nonsustained ventricular tachycardia, ventricular fibrillation responsible for sudden death...
January 5, 2018: Pacing and Clinical Electrophysiology: PACE
Yu-Fan Yang, Ke Peng, Hong Liu, Xiao-Wen Meng, Jing-Jing Zhang, Fu-Hai Ji
Pharmacological preconditioning reduces myocardial infarct size in ischaemia-reperfusion (I-R) injury. Dexmedetomidine, a selective α2 -adrenoceptor agonist, has a proven cardioprotective effect when administered prior to I-R, although the underlying mechanisms for this effect are not fully understood. We evaluated whether dexmedetomidine preconditioning could induce a myocardio-protective effect against I-R injury by inhibiting associated inflammatory processes through downregulation of the high mobility group box 1 (HMGB1)-toll-like receptor 4 (TLR4)-nuclear factor κB (NF-κB) signalling pathway...
March 2017: Clinical and Experimental Pharmacology & Physiology
Aristeidis G Vaiopoulos, Kyriakoula Marinou, Constantinos Christodoulides, Michael Koutsilieris
Adiponectin (ApN) is an adipose tissue-derived hormone which is involved in a wide variety of physiological processes including energy metabolism, inflammation, and vascular physiology via actions on a broad spectrum of target organs including liver, skeletal muscle, and vascular endothelium. Besides possessing insulin sensitizing and anti-inflammatory properties ApN also exerts a pivotal role in vascular protection through activation of multiple intracellular signaling cascades. Enhancement of nitric oxide generation and attenuation of reactive oxygen species production in endothelial cells along with reduced vascular smooth muscle cell proliferation and migration constitute some of ApN's vasoprotective actions...
March 8, 2012: International Journal of Cardiology
P Jerie
Organic nitrates still constitute, like digitalis, an indispensable remedy. Amyl nitrite, discovered by Balard was the first to be used for the therapy of angina pectoris by Sir T. Lauder Brunton in 1867. Nitroglycerin (Glyceroltrinitrate) was synthetized by Ascanio Sobrero 1846 and was studied by Brunton, Tate, and Murrel who published his paper on the treatment of angina pectoris in 1879. It has been soon recognised that the main effect of nitrates is vasodilatation more pronounced in the veins, resulting in reduced venous return, decrease of left and right ventricular end-diastolic pressure and volume and in a reduction in the myocardioal oxygen demand...
2007: Casopís Lékar̆ů C̆eských
No abstract text is available yet for this article.
October 10, 1963: Minerva Medica
No abstract text is available yet for this article.
1962: Atti Della Società Italiana di Cardiologia
A I Kuzin
The analysis of evidence obtained at coronaroangiography, myocardial scintigraphy, echocardiography, severity of coronary and heart insufficiency in patients with isolated and combined forms of ischemic heart disease and arterial hypertension has identified three types of structural-functional relations between characteristics of coronary circulation and myocardial status: myocardio-perfusional (concentric myocardial hypertrophy with diastolic dysfunction leading to perfusional defects), coronaro-myocardial (affection of coronary arteries resulting in myocardial lesion with primarily systolic dysfunction), coronaro-perfusional (disturbed coronary circulation in involvement of coronary and myocardial factors)...
October 1999: Patologicheskaia Fiziologiia i èksperimental'naia Terapiia
M Shimizu, Q D Wang, P O Sjöquist, R Nordlander, L Rydén
The objective of this study was to test the hypothesis that treatment with the calcium antagonist felodipine in normal clinical dosages may have a myocardio-protective effect in the event of ischemia followed by reperfusion. Comparing the cardioprotective effects of felodipine and an agent of another class allowed the influence of blood pressure reduction per se to be evaluated. Twenty open-chest pigs were exposed to 45 minutes of myocardial ischemia via occlusion of the left anterior descending coronary artery (LAD) followed by 240 minutes of reperfusion...
March 1998: Cardiovascular Drugs and Therapy
J P Lethor, F Marcon, G Bosser, P Y Marie, H Lucron, A M Worms
During a routine medical check-up, a pathological electrocardiogram was recorded in an asymptomatic 6 year old girl. The demonstration of coronary insufficiency by exercise stress testing and sestamib myocardio-scintigraphy led to the diagnosis of an anomalous origin of the left coronary artery. This vessel arose from the right coronary sinus and continued anteriorly to the main coronary artery. The data of the literature suggest that the risk of sudden death and of coronary insufficiency is associated with the passage of the left coronary artery between the aorta and pulmonary artery...
May 1996: Archives des Maladies du Coeur et des Vaisseaux
C Nava, G Briatico-Vangosa, M Marchisio
No abstract text is available yet for this article.
July 1973: La Medicina del Lavoro
W D Bussmann, M Rauh, H P Krayenbuehl
No abstract text is available yet for this article.
March 1970: American Heart Journal
A J Bezerra, J C Prates, L J DiDio
The incidence of bridges of myocardium seen on the external surface of the heart, through the epicardium, over portions of coronary arteries and their branches, was studied in 50 cadavers and found to be 78%. The bridges of the myocardium varied in size and in number (from one to six). Their location was predominantly found at the level of the anterior ventricular branch of the left coronary artery also called left anterior descending artery (52%), whereas in the territory of the right coronary artery the highest percentage was at the level of the anterior ventricular branch (12%)...
1987: Surgical and Radiologic Anatomy: SRA
P A Fernández de la Vega Romo, A A Ehsani, J O Hollosy, B E Sobel, J Hagberg, G Heath
Training with resistant exercises has been proved to be beneficial for patients of ischemic cardiopathy. This kind of training increases working capacity, provided the exercise is maintained in the necessary threshold to avoid starting a chest angina. Nevertheless, there is no clear evidence of an increase in the blood flooding of the myocardio, the left ventricle function or the heart electric stability as a consequence of the said training. It's our opinion that the principal reasons for this lack of evidence are: a) insufficient research, b) the existence of technical difficulties for developing certain phases of the necessary research, and maybe that, c) some exercise programs are not sufficiently long and intense and to induce myocardial adaptation...
November 1978: Archivos del Instituto de Cardiología de México
F D Loop, N R Carabajal, P C Taylor, M J Irarrazaval
Thirty-two consecutive patients who earlier received indirect or direct myocardial revascularization underwent reoperation with one or more internal mammary artery grafts either alone or in combination with saphenous vein grafts. The main indication for reoperation was graft closure or progression of coronary atherosclerosis in nongrafted vessels, or both. Graft construction was performed under normothermic perfusion and anoxic arrest with interrupted suture technique. No intraoperative infarctions or hospital deaths occurred...
May 1976: American Journal of Cardiology
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