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https://www.readbyqxmd.com/read/29667122/the-gene-editing-of-super-ego
#1
Bjørn Hofmann
New emerging biotechnologies, such as gene editing, vastly extend our ability to alter the human being. This comes together with strong aspirations to improve humans not only physically, but also mentally, morally, and socially. These conjoined ambitions aggregate to what can be labelled "the gene editing of super-ego." This article investigates a general way used to argue for new biotechnologies, such as gene-editing: if it is safe and efficacious to implement technology X for the purpose of a common good Y, why should we not do so? This is a rhetorical question with a conditional, and may be dismissed as such...
April 17, 2018: Medicine, Health Care, and Philosophy
https://www.readbyqxmd.com/read/29663396/internet-trolling-and-everyday-sadism-parallel-effects-on-pain-perception-and-moral-judgment
#2
Erin E Buckels, Paul D Trapnell, Tamara Andjelovic, Delroy L Paulhus
OBJECTIVE: To clarify the association between online trolling and sadistic personality; and provide evidence that the reward and rationalization processes at work in sadism are likewise manifest in online trolling. METHOD: Online respondents (total N = 1,715) completed self-report measures of personality and trolling behavior. They subsequently engaged in one of two judgment tasks. In Study 1, respondents viewed stimuli depicting scenes of emotional/physical suffering, and provided ratings of (a) perceived pain intensity and (b) pleasure experienced while viewing the photos...
April 16, 2018: Journal of Personality
https://www.readbyqxmd.com/read/29663150/preparation-of-a-novel-lipid-core-micelle-using-a-low-energy-emulsification-method
#3
Hans F Fritz, Andrea C Ortiz, Sitaram P Velaga, Javier O Morales
High-energy methods for the manufacturing of nanomedicines are widely used; however, interest in low-energy methods is increasing due to their simplicity, better control over the process, and energy-saving characteristics during upscaling. Here, we developed a novel lipid-core micelle (LCM) as a nanocarrier to encapsulate a poorly water-soluble drug, nifedipine (NFD), by hot-melt emulsification, a low-energy method. LCMs are self-assembling colloidal particles composed of a hydrophobic core and a hydrophilic shell...
April 16, 2018: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29662529/neoadjuvant-chemotherapy-in-locally-advanced-duodenal-adenocarcinoma
#4
Carlos Velandia, Rafael Delgado Morales, Carlos Coello, Armando Gil Mendoza, Gabriel Pérez, Emperatriz Aguero
Duodenal adenocarcinoma (ADC) represents only 0.3% of gastrointestinal neoplasms. With the frequency being higher between the ages of 40 and 60, it is predominantly located in the second part of the duodenum and around the periampullary region. Symptoms are nonspecific, so the majority of patients present with advanced disease. Neoadjuvant chemotherapy is a therapeutic option that has not been well studied. The global literature includes only isolated reports on this subject. This is why we are presenting the following case: a 60-year-old female patient with a locally advanced, inoperable duodenal ADC received neoadjuvant chemotherapy...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29662297/graphics-processing-unit-enhanced-genetic-algorithms-for-solving-the-temporal-dynamics-of-gene-regulatory-networks
#5
REVIEW
Raúl García-Calvo, J L Guisado, Fernando Diaz-Del-Rio, Antonio Córdoba, Francisco Jiménez-Morales
Understanding the regulation of gene expression is one of the key problems in current biology. A promising method for that purpose is the determination of the temporal dynamics between known initial and ending network states, by using simple acting rules. The huge amount of rule combinations and the nonlinear inherent nature of the problem make genetic algorithms an excellent candidate for finding optimal solutions. As this is a computationally intensive problem that needs long runtimes in conventional architectures for realistic network sizes, it is fundamental to accelerate this task...
2018: Evolutionary Bioinformatics Online
https://www.readbyqxmd.com/read/29661182/women-s-perspectives-on-the-ethical-implications-of-non-invasive-prenatal-testing-a-qualitative-analysis-to-inform-health-policy-decisions
#6
Meredith Vanstone, Alexandra Cernat, Jeff Nisker, Lisa Schwartz
BACKGROUND: Non-Invasive Prenatal Testing (NIPT) is a technology which provides information about fetal genetic characteristics (including sex) very early in pregnancy by examining fetal DNA obtained from a sample of maternal blood. NIPT is a morally complex technology that has advanced quickly to market with a strong push from industry developers, leaving many areas of uncertainty still to be resolved, and creating a strong need for health policy that reflects women's social and ethical values...
April 16, 2018: BMC Medical Ethics
https://www.readbyqxmd.com/read/29661169/rna-seq-reveals-the-existence-of-a-cdkn1c-e2f1-tp53-axis-that-is-altered-in-human-t-cell-lymphoblastic-lymphomas
#7
Pilar López-Nieva, Pablo Fernández-Navarro, Concepción Vaquero-Lorenzo, María Villa-Morales, Osvaldo Graña-Castro, María Ángeles Cobos-Fernández, José Luis López-Lorenzo, Pilar Llamas, Laura González-Sanchez, Isabel Sastre, Marina Pollan, Marcos Malumbres, Javier Santos, José Fernández-Piqueras
BACKGROUND: Precursor T-cell lymphoblastic lymphomas (T-LBL) are rare aggressive hematological malignancies that mainly develop in children. As in other cancers, the loss of cell cycle control plays a prominent role in the pathogenesis in these malignancies that is primarily attributed to loss of CDKN2A (encoding protein p16INK4A). However, the impact of the deregulation of other genes such as CDKN1C, E2F1, and TP53 remains to be clarified. Interestingly, experiments in mouse models have proven that conditional T-cell specific deletion of Cdkn1c gene may induce a differentiation block at the DN3 to DN4 transition, and that the loss of this gene in the absence of Tp53 led to aggressive thymic lymphomas...
April 16, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29660001/translatome-analysis-at-the-egg-to-embryo-transition-in-sea-urchin
#8
Héloïse Chassé, Julie Aubert, Sandrine Boulben, Gildas Le Corguillé, Erwan Corre, Patrick Cormier, Julia Morales
Early embryogenesis relies on the translational regulation of maternally stored mRNAs. In sea urchin, fertilization triggers a dramatic rise in translation activity, necessary for the onset of cell division. Here, the full spectrum of the mRNAs translated upon fertilization was investigated by polysome profiling and sequencing. The translatome of the early sea urchin embryo gave a complete picture of the polysomal recruitment dynamics following fertilization. Our results indicate that only a subset of maternal mRNAs were selectively recruited onto polysomes, with over-represented functional categories in the translated set...
April 6, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29659331/comparative-analysis-of-aging-policy-reforms-in-argentina-chile-costa-rica-and-mexico
#9
Esteban Calvo, Maureen Berho, Mónica Roqué, Juan Sebastián Amaro, Fernando Morales, Emiliana Rivera, Luis Miguel F Gutiérrez Robledo, Elizabeth Caro López, Bernardita Canals, Rosa Kornfeld
This investigation uses case studies and comparative analysis to review and analyze aging policy in Argentina, Chile, Costa Rica, and Mexico, and uncovers similarities and relevant trends in the substance of historical and current aging policy across countries. Initial charity-based approaches to poverty and illness have been gradually replaced by a rights-based approach considering broader notions of well-being, and recent reforms emphasize the need for national, intersectoral, evidence-based policy. The results of this study have implications for understanding aging policy in Latin America from a welfare regime and policymakers' perspective, identifying priorities for intervention, and informing policy reforms in developing countries worldwide...
April 16, 2018: Journal of Aging & Social Policy
https://www.readbyqxmd.com/read/29658728/-beyond-sacrificial-harm-a-two-dimensional-model-of-utilitarian-psychology-correction
#10
(no author information available yet)
Reports an error in "Beyond Sacrificial Harm: A Two-Dimensional Model of Utilitarian Psychology" by Guy Kahane, Jim A. C. Everett, Brian D. Earp, Lucius Caviola, Nadira S. Faber, Molly J. Crockett and Julian Savulescu ( Psychological Review , Advanced Online Publication, Dec 21, 2017, np). The copyright attribution was incorrectly listed, and the Creative Commons CC-BY license disclaimer was incorrectly omitted from the author note. The correct copyright is "© 2017 The Author(s)" and the omitted disclaimer is presented in the erratum...
March 2018: Psychological Review
https://www.readbyqxmd.com/read/29657348/rawls-s-wide-reflective-equilibrium-as-a-method-for-engaged-interdisciplinary-collaboration-potentials-and-limitations-for-the-context-of-technological-risks
#11
Neelke Doorn, Behnam Taebi
The introduction of new technologies in society is sometimes met with public resistance. Supported by public policy calls for "upstream engagement" and "responsible innovation," recent years have seen a notable rise in attempts to attune research and innovation processes to societal needs, so that stakeholders' concerns are taken into account in the design phase of technology. Both within the social sciences and in the ethics of technology, we see many interdisciplinary collaborations being initiated that aim to address tensions between various normative expectations about science and engineering and the actual outcomes...
May 2018: Science, Technology & Human Values
https://www.readbyqxmd.com/read/29657312/left-upper-quadrant-appendicitis-in-a-patient-with-congenital-intestinal-malrotation-and-polysplenia
#12
Camille Lupiañez-Merly, Stephanie C Torres-Ayala, Lorena Morales, Adel Gonzalez, José A Lara-Del Rio, Ivonne Ojeda-Boscana
BACKGROUND Appendicitis is the most common cause of abdominal pain requiring emergent surgical intervention. Although typically presenting as right lower-quadrant pain, in rare cases it may present as left upper-quadrant pain secondary to abnormal position due to intestinal malrotation. Since atypical presentations may result in diagnostic and management delay, increasing morbidity and mortality, accurate and prompt diagnosis is important. Therefore, acute appendicitis should be considered in the differential diagnosis of left upper-quadrant abdominal pain...
April 16, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29653347/development-and-validation-of-a-bioassay-to-evaluate-binding-of-adalimumab-to-cell-membrane-anchored-tnf%C3%AE-using-flow-cytometry-detection
#13
Rosa Camacho-Sandoval, Eréndira N Sosa-Grande, Edith González-González, Alejandra Tenorio-Calvo, Carlos A López-Morales, Marco Velasco-Velázquez, Lenin Pavón-Romero, Sonia Mayra Pérez-Tapia, Emilio Medina-Rivero
Physicochemical and structural properties of proteins used as active pharmaceutical ingredients of biopharmaceuticals are determinant to carry out their biological activity. In this regard, the assays intended to evaluate functionality of biopharmaceuticals provide confirmatory evidence that they contain the appropriate physicochemical properties and structural conformation. The validation of the methodologies used for the assessment of critical quality attributes of biopharmaceuticals is a key requirement for manufacturing under GMP environments...
March 30, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29653023/%C3%AE-aminobutyric-acid-quantification-in-small-volume-biological-samples-through-enzymatically-induced-electrochemiluminescence
#14
Juan Carlos Salazar-Sánchez, Alberto Morales-Villagrán, Silvia Josefina López-Pérez, Kenia Pardo-Peña, Fridha Villalpando-Vargas, Laura Medina-Ceja
γ-Aminobutyric acid (GABA) is a well-known neurotransmitter that regulates inhibitory neurotransmission in the mammalian central nervous system and participates in several processes outside the brain. A reliable quantification method is needed to determine its role in different physiological and pathological conditions. However, GABA measurements have several challenges because GABA is neither fluorescent nor electroactive, and it is difficult to detect using enzymatic reactions because no oxidases or dehydrogenases have been identified...
April 13, 2018: Luminescence: the Journal of Biological and Chemical Luminescence
https://www.readbyqxmd.com/read/29651269/self-reported-risk-and-delinquent-behavior-and-problem-behavioral-intention-in-hong-kong-adolescents-the-role-of-moral-competence-and-spirituality
#15
Daniel T L Shek, Xiaoqin Zhu
Based on the six-wave data collected from Grade 7 to Grade 12 students ( N = 3,328 at Wave 1), this pioneer study examined the development of problem behaviors (risk and delinquent behavior and problem behavioral intention) and the predictors (moral competence and spirituality) among adolescents in Hong Kong. Individual growth curve models revealed that while risk and delinquent behavior accelerated and then slowed down in the high school years, adolescent problem behavioral intention slightly accelerated over time...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29650198/analysis-on-the-implementation-of-a-health-improvement-project-garbage-clinical-insurance-in-indonesia-a-literature-review
#16
Efa Apriyanti
OBJECTIVE: Indonesia Medika has established "Garbage Clinical Insurance" (GCI), which enables the population below the poverty line (BPL) to obtain health insurance by donating their garbage to pay the premium. The objective of this paper was to critically examine the implementation of GCI in Indonesia by reviewing the background, effects, and sustainability of this program. METHOD: A literature search of studies related to GCI, other types of micro health insurance, and their applications in developing countries was conducted...
February 2018: Enfermería Clínica
https://www.readbyqxmd.com/read/29627144/-assessing-bioethics-education-teaching-to-be-virtuous-doctors-or-just-doctors-with-practical-ethical-skills
#17
Montse Esquerda, Josep Pifarré, Helena Roig, Ester Busquets, Oriol Yuguero, Joan Viñas
OBJECTIVE: In the last decades, bioethics has been incorporated into the academic training of the Medical Schools. Some studies analyze the ethical-moral development of medical students and the effect of ethical education in other countries. This evaluation is done by measuring Kohlberg's moral reasoning (virtuous doctors), or ethical sensitivity to resolve clinical cases (physicians with ethical skills). The following study is proposed to assess the impact of bioethics training on these two variables, in Spanish medical students...
April 4, 2018: Atencion Primaria
https://www.readbyqxmd.com/read/29625576/skeletal-cardiac-and-respiratory-muscle-function-and-histopathology-in-the-p448lneo-mouse-model-of-fkrp-deficient-muscular-dystrophy
#18
Qing Yu, Melissa Morales, Ning Li, Alexander G Fritz, Ren Ruobing, Anthony Blaeser, Ershia Francois, Qi-Long Lu, Kanneboyina Nagaraju, Christopher F Spurney
BACKGROUND: Fukutin-related protein (FKRP) mutations are the most common cause of dystroglycanopathies known to cause both limb girdle and congenital muscular dystrophy. The P448Lneo- mouse model has a knock-in mutation in the FKRP gene and develops skeletal, respiratory, and cardiac muscle disease. METHODS: We studied the natural history of the P448Lneo- mouse model over 9 months and the effects of twice weekly treadmill running. Forelimb and hindlimb grip strength (Columbus Instruments) and overall activity (Omnitech Electronics) assessed skeletal muscle function...
April 6, 2018: Skeletal Muscle
https://www.readbyqxmd.com/read/29623707/quantitative-sims-imaging-of-agar-based-microbial-communities
#19
Sage J B Dunham, Joseph F Ellis, Nameera F Baig, Nydia Morales-Soto, Tianyuan Cao, Joshua D Shrout, Paul W Bohn, Jonathan V Sweedler
After several decades of widespread use for mapping elemental ions and small molecular fragments in surface science, secondary ion mass spectrometry (SIMS) has emerged as a powerful analytical tool for molecular imaging in biology. SIMS has primarily been used as a qualitative technique; although the distribution of a single analyte can be accurately determined, it is difficult to map the absolute quantity of a compound, or even to compare the relative abundance of one molecular species to that of another. We describe a method for quantitative SIMS imaging of small molecules in agar-based microbial communities...
April 6, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29622282/-the-more-you-know-the-more-you-realise-it-is-really-challenging-to-do-tensions-and-uncertainties-in-person-centred-support-for-people-with-long-term-conditions
#20
Vikki A Entwistle, Alan Cribb, Ian S Watt, Zoë C Skea, John Owens, Heather M Morgan, Simon Christmas
OBJECTIVE: To identify and examine tensions and uncertainties in person-centred approaches to self-management support - approaches that take patients seriously as moral agents and orient support to enable them to live (and die) well on their own terms. METHODS: Interviews with 26 UK clinicians about working with people with diabetes or Parkinson's disease, conducted within a broader interdisciplinary project on self-management support. The analysis reported here was informed by philosophical reasoning and discussions with stakeholders...
March 30, 2018: Patient Education and Counseling
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