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Moral Development

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https://www.readbyqxmd.com/read/28454292/dna-vaccine-encoding-human-papillomavirus-antigens-flanked-by-a-signal-peptide-and-a-kdel-sequence-induces-a-potent-therapeutic-antitumor-effect
#1
Jose J Perez-Trujillo, Rodolfo Garza-Morales, Jose A Barron-Cantu, Gabriel Figueroa-Parra, Aracely Garcia-Garcia, Humberto Rodriguez-Rocha, Jaime Garcia-Juarez, Gerardo E Muñoz-Maldonado, Odila Saucedo-Cardenas, Roberto Montes-De-Oca-Luna, Maria De Jesus Loera-Arias
Cellular immune responses play a critical role in the eradication of intracellular infections and malignant cells through the recognition and subsequent removal of the infection or malignant cells. Effective antigen presentation is crucial for stimulating the immune system against malignant cells. Calreticulin (CRT) has been used to improve antigen presentation. However, CRT overexpression has been previously associated with the development of pancreatic and breast cancer. The import and retention signals of CRT in the endoplasmic reticulum (ER) can be used to overcome CRT overexpression...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28442549/neuraminidases-3-and-4-regulate-neuronal-function-by-catabolizing-brain-gangliosides
#2
Xuefang Pan, Camila De Britto Pará De Aragão, Juan P Velasco-Martin, David A Priestman, Harry Y Wu, Kohta Takahashi, Kazunori Yamaguchi, Luisella Sturiale, Domenico Garozzo, Frances M Platt, Nathalie Lamarche-Vane, Carlos R Morales, Taeko Miyagi, Alexey V Pshezhetsky
Gangliosides (sialylated glycolipids) play an essential role in the CNS by regulating recognition and signaling in neurons. Metabolic blocks in processing and catabolism of gangliosides result in the development of severe neurologic disorders, including gangliosidoses manifesting with neurodegeneration and neuroinflammation. We demonstrate that 2 mammalian enzymes, neuraminidases 3 and 4, play important roles in catabolic processing of brain gangliosides by cleaving terminal sialic acid residues in their glycan chains...
April 25, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28433933/functional-foods-in-pet-nutrition-focus-on-dogs-and-cats
#3
REVIEW
Alessandro Di Cerbo, Julio Cesar Morales-Medina, Beniamino Palmieri, Federica Pezzuto, Raffaella Cocco, Gonzalo Flores, Tommaso Iannitti
Functional foods provide health benefits if they are consumed on a regular basis as part of a varied diet. In this review, we discuss the availability and role of functional foods in pet nutrition with a focus on dogs and cats. Indeed, functional foods modify gastrointestinal physiology, promote changes in biochemical parameters, improve brain functions and may reduce or minimize the risk of developing specific pathologies. This evidence derives largely from clinical studies while only limited evidence is available from studies in dogs and cats...
April 7, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28431897/failure-renal-aetiology-in-patients-with-infective-endocarditis-the-role-of-antibiotics
#4
Miguel Ángel Goenaga Sánchez, Xabier Kortajarena Urkola, Emilio Bouza Santiago, Patricia Muñoz García, Eduardo Verde Moreno, M Carmen Fariñas Álvarez, Ramón Teira Cobo, Juan Manuel Pericás Pulido, Arístides de Alarcón González, Dolores Sousa Regueiro, Josefa Ruiz Morales, Regino José Rodríguez-Álvarez, Isabel Antorrena Miranda, José Antonio Iribarren Loyarte
BACKGROUND AND OBJECTIVES: The possible renal toxicity of certain antibiotics (AB) is well known. The objective of our work is to know the possible effect of AB treatments in the development of renal failure (RF) in patients with infective endocarditis (IE). MATERIAL AND METHOD: Collection from a national multi-centre registry of collection on renal function, both prior and its impairment, if any, during the treatment of IE and in relation to possible causative factors, including the use of AB...
April 18, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28430568/reflection-based-learning-for-professional-ethical-formation
#5
William T Branch, Maura George
One way practitioners learn ethics is by reflecting on experience. They may reflect in the moment (reflection-in-action) or afterwards (reflection-on-action). We illustrate how a teaching clinician may transform relationships with patients and teach person-centered care through reflective learning. We discuss reflective learning pedagogies and present two case examples of our preferred method, guided group reflection using narratives. This method fosters moral development alongside professional identity formation in students and advanced learners...
April 1, 2017: AMA Journal of Ethics
https://www.readbyqxmd.com/read/28430191/activating-lattice-oxygen-redox-reactions-in-metal-oxides-to-catalyse-oxygen-evolution
#6
Alexis Grimaud, Oscar Diaz-Morales, Binghong Han, Wesley T Hong, Yueh-Lin Lee, Livia Giordano, Kelsey A Stoerzinger, Marc T M Koper, Yang Shao-Horn
Understanding how materials that catalyse the oxygen evolution reaction (OER) function is essential for the development of efficient energy-storage technologies. The traditional understanding of the OER mechanism on metal oxides involves four concerted proton-electron transfer steps on metal-ion centres at their surface and product oxygen molecules derived from water. Here, using in situ (18)O isotope labelling mass spectrometry, we provide direct experimental evidence that the O2 generated during the OER on some highly active oxides can come from lattice oxygen...
May 2017: Nature Chemistry
https://www.readbyqxmd.com/read/28429528/use-of-adenosine-to-shorten-the-post-ablation-waiting-period-for-cavotricuspid-isthmus-dependent-atrial-flutter
#7
Gustavo Morales, Yousef H Darrat, Nicolas Lellouche, Sun Moon Kim, Muhammad Butt, Katrina Bidwell, William Lippert, Gbolahan Ogunbayo, David Hamon, Luigi Di Biase, Andrea Natale, Kevin Parrott, Claude S Elayi
BACKGROUND: Dormant conduction unmasked by adenosine predicts clinical recurrences of cavotricuspid isthmus (CTI) dependent atrial flutter following catheter ablation. Conventional practice involves a waiting period of 20 to 30 minutes after achievement of a bidirectional line of block (BDB) to monitor for recovery of conduction. OBJECTIVE: Assess whether abolition of dormant conduction with adenosine immediately after CTI ablation and BDB can predict the lack of CTI conduction recovery during the following 30 minutes...
April 21, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28429249/are-there-moral-differences-between-maternal-spindle-transfer-and-pronuclear-transfer
#8
César Palacios-González
This paper examines whether there are moral differences between the mitochondrial replacement techniques that have been recently developed in order to help women afflicted by mitochondrial DNA diseases to have genetically related children absent such conditions: maternal spindle transfer (MST) and pronuclear transfer (PNT). Firstly, it examines whether there is a moral difference between MST and PNT in terms of the divide between somatic interventions and germline interventions. Secondly, it considers whether PNT and MST are morally distinct under a therapy/creation optic...
April 20, 2017: Medicine, Health Care, and Philosophy
https://www.readbyqxmd.com/read/28427303/values-based-practice-a-framework-for-thinking-with
#9
Kay Mohanna
Values are those principles that govern behaviours, and values-based practice has been described as a theory and skills base for effective healthcare decision-making where different (and hence potentially conflicting) values are in play. The emphasis is on good process rather than pre-set right outcomes, aiming to achieve balanced decision-making. In this article we will consider the utility of this model by looking at leadership development, a current area of much interest and investment in healthcare. Copeland points out that 'values based leadership behaviors are styles with a moral, authentic and ethical dimension', important qualities in healthcare decision-making...
April 21, 2017: Education for Primary Care
https://www.readbyqxmd.com/read/28426307/how-california-prepared-for-implementation-of-physician-assisted-death-a-primer
#10
Laura A Petrillo, Elizabeth Dzeng, Krista L Harrison, Lindsay Forbes, Benjamin Scribner, Barbara A Koenig
Physician-assisted death is now legal in California, and similar laws are being considered in many other states. The California law includes safeguards, yet health care providers will face practical and ethical issues while implementing physician-assisted death that are not addressed by the law. To help providers and health care facilities in California prepare to provide optimal care to patients who inquire about physician-assisted death, we brought together experts from California, Oregon, and Washington...
April 20, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28425313/moral-distress-among-school-nurses
#11
Shannon Baker Powell, Martha Keehner Engelke, Melvin S Swanson
School nurses are well positioned to provide care to a diverse population of school-age children, but their role and work environment can present a variety of moral dilemmas leading to moral distress. The purpose of this study is to identify the moral distress level that exists in school nurses and to describe its relationship to common moral dilemmas and school nurse characteristics. Data were collected through face-to-face attendance at school nurse meetings in North Carolina where 307 school nurses participated in the survey...
January 1, 2017: Journal of School Nursing: the Official Publication of the National Association of School Nurses
https://www.readbyqxmd.com/read/28425287/vertical-charge-transfer-and-lateral-transport-in-graphene-germanium-heterostructures
#12
Alireza Kazemi, Sam Vaziri, Jorge Daniel Aguirre Morales, Sebastien Fregonese, Francesca Cavallo, Marziyeh Zamiri, Noel Mayur Dawson, Kateryna Artyushkova, Ying Bing Jiang, Steven R J Brueck, Sanjay Krishna
Heterostructures consisting of two-dimensional (2D) materials and conventional semiconductors have attracted a lot of attention due to their application in novel device concepts. In this work, we investigated the lateral transport characteristics of graphene/germanium heterostructures and compared it with the transport properties of graphene on SiO2. The heterostructures were fabricated by transferring a single layer graphene (Gr) onto lightly doped germanium (Ge) (100) substrate. The field effect measurements revealed a shift in the Dirac voltage of Gr on Ge substrates compared to the Gr on SiO2...
April 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28424592/new-implications-for-the-melanocortin-system-in-alcohol-drinking-behavior-in-adolescents-the-glial-dysfunction-hypothesis
#13
Juan A Orellana, Waldo Cerpa, Maria F Carvajal, José M Lerma-Cabrera, Eduardo Karahanian, Cesar Osorio-Fuentealba, Rodrigo A Quintanilla
Alcohol dependence causes physical, social, and moral harms and currently represents an important public health concern. According to the World Health Organization (WHO), alcoholism is the third leading cause of death worldwide, after tobacco consumption and hypertension. Recent epidemiologic studies have shown a growing trend in alcohol abuse among adolescents, characterized by the consumption of large doses of alcohol over a short time period. Since brain development is an ongoing process during adolescence, short- and long-term brain damage associated with drinking behavior could lead to serious consequences for health and wellbeing...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28423419/temperature-dependent-biological-and-demographic-parameters-of-coleomegilla-maculata-coleoptera-coccinellidae
#14
Juan A Morales-Ramos, M Guadalupe Rojas
Knowledge of the most suitable environmental conditions for an organism growth and development is a prerequisite for developing mass rearing technology. The temperature requirements for development and the optimal range of temperatures for growth and reproduction of Coleomegilla maculata De Geer were studied. The development time of individual C. maculata larvae was determined at 18, 21, 24, 27, 30, 33, and 36 °C. Development times were converted to development rates and fitted to a nonlinear temperature-dependent model and to the linear day-degree model...
January 1, 2017: Journal of Insect Science
https://www.readbyqxmd.com/read/28421865/it-s-not-all-about-moral-reasoning-understanding-the-content-of-moral-case-deliberation
#15
Mia Svantesson, Marit Silén, Inger James
BACKGROUND: Moral Case Deliberation is one form of clinical ethics support described as a facilitator-led collective moral reasoning by healthcare professionals on a concrete moral question connected to their practice. Evaluation research is needed, but, as human interaction is difficult to standardise, there is a need to capture the content beyond moral reasoning. This allows for a better understanding of Moral Case Deliberation, which may contribute to further development of valid outcome criteria and stimulate the normative discussion of what Moral Case Deliberation should contain...
January 1, 2017: Nursing Ethics
https://www.readbyqxmd.com/read/28419446/from-autonomy-to-divinity-the-cultural-socialization-of-moral-reasoning-in-an-evangelical-christian-community
#16
Allison DiBianca Fasoli
This study examined moral reasoning in parent-child conversations within a U.S. evangelical Christian community. The goal was to identify social-communicative processes that may promote the development of Divinity in children's moral reasoning. Sixteen parent-child dyads (6-9 years old) discussed hypothetical moral vignettes about failures to help peers in need. Analyses revealed that Divinity typically co-occurred with Autonomy in these conversations and that such co-occurrences typically happened through three distinct social-communicative processes, labeled "align," "scaffold," and "counter...
April 17, 2017: Child Development
https://www.readbyqxmd.com/read/28417686/trauma-epidemiology-in-puerto-rico-in-hospital-morbidity-and-mortality-from-2002-to-2011
#17
Annette Pascual-Marrero, Ediel O Ramos-Meléndez, Omar García-Rodríguez, José E Morales-Quiñones, Pablo Rodríguez-Ortiz
This study aimed to describe the distribution of injury mechanisms and to assess the impact of those mechanisms on the morbidity and mortality of trauma. All patients admitted to Puerto Rico Trauma Hospital (2002-2011) for road-traffic collisions (RTCs, 5,371), gunshot wounds (GSWs, 2,946), falls (2,319), pedestrian accidents (1,652), and stab wounds (SWs, 1,073) were selected. Gunshot victims were 1.19 (95%CI: 1.07-1.33) times as likely as road-traffic victims to have an ISS ≥25. Pedestrians were 1.76 (95%CI: 1...
April 18, 2017: International Journal of Injury Control and Safety Promotion
https://www.readbyqxmd.com/read/28416578/quantitative-mass-spectrometry-analysis-of-pd-l1-protein-expression-n-glycosylation-and-expression-stoichiometry-with-pd-1-and-pd-l2-in-human-melanoma
#18
Carlos A Morales-Betanzos, Hyoungjoo Lee, Paula I Gonzalez-Ericsson, Justin M Balko, Douglas B Johnson, Lisa J Zimmerman, Daniel C Liebler
Quantitative assessment of key proteins that control the tumor-immune interface is one of the most formidable analytical challenges in immunotherapeutics. We developed a targeted mass spectrometry (MS) platform to quantify programmed cell death-1 (PD-1), programmed cell death 1 ligand 1 (PD-L1), and programmed cell death 1 ligand 2 (PD-L2) at fmol/microgram protein levels in formalin fixed, paraffin-embedded sections from 22 human melanomas. PD-L1 abundance ranged 50-fold, from approximately 0.03 to 1.5 fmol/microgram protein and the PRM data were largely concordant with total PD-L1-positive cell content, as analyzed by immunohistochemistry (IHC) with the E1L3N antibody...
April 17, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28416193/lep-rs7799039-lepr-rs1137101-and-adipoq-rs2241766-and-1501299-polymorphisms-are-associated-with-obesity-and-chemotherapy-response-in-mexican-women-with-breast-cancer
#19
Alejandra Méndez-Hernández, Martha Patricia Gallegos-Arreola, Hortensia Moreno-Macías, Jorge Espinosa Fematt, Rebeca Pérez-Morales
BACKGROUND: Obesity plays a major role in the pathogenesis of breast cancer. Leptin (LEP) and adiponectin (ADIPOQ) are important in the regulation of adipose tissue. The response to cancer treatment depends on the histological and molecular tumor type, clinical stage, and genetic variability that might promote carcinogenic development. The aim of this study was to investigate the association between overweight/obesity and polymorphisms in the LEP (rs7799039), LEP receptor (LEPR; rs1137101), and ADIPOQ genes (rs2241766, rs1501299) with the response to breast cancer treatment in Mexican women...
March 22, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28414548/assessing-state-mental-contamination-development-and-preliminary-validation-of-the-state-mental-contamination-scale
#20
Rosemond T Lorona, Wade C Rowatt, Thomas A Fergus
This 2-part study described the development and preliminary validation of the State Mental Contamination Scale (SMCS), a multi-item self-report measure of state mental contamination. In Study 1, community adults (N = 211) in the United States were randomly assigned to a pathogen disgust, moral disgust, or neutral condition and then completed the SMCS. Study 1 results supported a 1-factor structure of the SMCS items. Scores on the SMCS items evidenced good internal consistency and strong interitem correlations...
April 17, 2017: Journal of Personality Assessment
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