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Acute otitis media in children

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https://www.readbyqxmd.com/read/28718488/infectious-disease-morbidity-and-growth-among-young-hiv-exposed-uninfected-children-in-jamaica
#1
Russell B Pierre, Toni-Anne Fulford, Kaye Lewis, Paulette Palmer, Christine Walters, Celia D C Christie
Objective: There is a growing body of data that demonstrates increased infectious disease outcomes for HIV-exposed uninfected (HIV-EU) infants as compared to their HIV-unexposed (HU) counterparts. We hypothesized that these HIV-EU infants are at greater risk for infectious morbidity and mortality when compared to the general childhood population. We therefore aimed to characterize infections and growth outcomes among HIV-EU infants in Jamaica during their first two years of life. By identifying these outcomes, specific interventions could be implemented to mitigate this risk of morbidity and mortality...
December 2016: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28711429/-appropriateness-of-antibiotic-prescribing-in-paediatric-patients-in-a-hospital-emergency-department
#2
Borja Croche Santander, Elena Campos Alonso, Adela Sánchez Carrión, Laura Marcos Fuentes, Isabel Diaz Flores, Juan Carlos Vargas, Bárbara Fernández Domínguez, Cristóbal Toro Ibañez
INTRODUCTION: Antibiotics represent one of the most widely prescribed therapeutic agents in children. It has been estimated that 30-50% of antibiotic prescriptions for this population are inappropriate. In this scenario, analysis of prescription data provides an invaluable source of information as a basis for implementing strategies for improvement in this field. OBJECTIVE: To assess the appropriateness of antibiotic prescriptions in a paediatric population at an emergency department...
July 12, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/28707578/acute-otitis-media-in-children
#3
Alexander Kc Leung, Alex H C Wong
BACKGROUND: Acute otitis media is a common childhood infection. Prompt diagnosis and appropriate treatment are very important. OBJECTIVE: To review in depth the epidemiology, pathophysiology, clinical manifestations, diagnosis, complications and particularly treatment of acute otitis media in children. METHODS: A PubMed search was completed in Clinical Queries using the key term "acute otitis media". Patents were searched using the key term "acute otitis media" from www...
July 12, 2017: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/28684920/bacteriotherapy-with-streptococcus-salivarius-24smb-and-streptococcus-oralis-89a-nasal-spray-for-preventing-recurrent-acute-otitis-media-in-children-a-real-life-clinical-experience
#4
Ignazio La Mantia, Attilio Varricchio, Giorgio Ciprandi
Recurrence of acute otitis media (RAOM) is a relevant issue in the clinical practice. "Bacteriotherapy" has been proposed as an option in children with RAOM. Streptococcus salivarius 24SMB nasal spray has been previously demonstrated to reduce the risk of acute otitis media (AOM) in otitis-prone children. The current retrospective and observational study aimed to confirm this outcome in a real-life setting, such as the common pediatric practice. Group A (108 children) served as control; group B (159 children) was treated with S...
2017: International Journal of General Medicine
https://www.readbyqxmd.com/read/28666536/a-cost-utility-analysis-of-5-strategies-for-the-management-of-acute-otitis-media-in-children
#5
Nader Shaikh, Emily E Dando, Mark L Dunleavy, Dorothy L Curran, Judith M Martin, Alejandro Hoberman, Kenneth J Smith
OBJECTIVE: To assess whether antimicrobial therapy in young children with acute otitis media reduces time to resolution of symptoms, overall symptom burden, and persistence of otoscopic evidence of infection. We used a cost-utility model to evaluate whether immediate antimicrobial treatment seems to be worthwhile, and if so, which antimicrobial agent is most cost effective. STUDY DESIGN: We compared the cost per quality-adjusted life-day of 5 treatment regimens in children younger than 2 years of age with acute otitis media: immediate amoxicillin/clavulanate, immediate amoxicillin, immediate cefdinir, watchful waiting, and delayed prescription (DP) for antibiotic...
June 28, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28616364/recurrent-acute-otitis-media-what-are-the-options-for-treatment-and-prevention
#6
REVIEW
Anna Granath
PURPOSE OF REVIEW: To survey current strategies for treatment and prevention of recurrent acute otitis media (rAOM). RECENT FINDINGS: Treatment with systemic antibiotics is required in recurrent episodes of acute otitis media. A cautious attitude is recommended due to antibiotic resistance. Antibiotics also provide effective prophylaxis for rAOM. Topical treatment with ear drops is recommended in rAOM with otorrhea from tympanostomy tubes. Pneumococcal conjugated vaccines seem to have a moderate reductive effect on overall otitis media...
2017: Current Otorhinolaryngology Reports
https://www.readbyqxmd.com/read/28576537/can-changes-in-parentally-measured-acoustic-reflectometry-levels-predict-the-middle-ear-status
#7
Nora Erkkola-Anttinen, Miia K Laine, Paula A Tähtinen, Aino Ruohola
OBJECTIVE: Spectral gradient acoustic reflectometry (SG-AR) may be used to detect middle ear effusion. Our aim was to investigate whether increasing SG-AR levels between two SG-AR examinations indicate deterioration from a healthy middle ear to acute otitis media (AOM). METHODS: We enrolled 185 children (age 6-35 months) whose parents were willing to use the SG-AR at home daily. Measurement pairs of parental home SG-AR examination results were generated and analyzed...
April 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28571504/impact-of-protein-d-containing-pneumococcal-conjugate-vaccines-on-non-typeable-haemophilus-influenzae-acute-otitis-media-and-carriage
#8
Christopher Clarke, Lauren O Bakaletz, Javier Ruiz-Guiñazú, Dorota Borys, Tomas Mrkvan
Protein D-containing vaccines may decrease acute otitis media (AOM) burden and nasopharyngeal carriage of non-typeable Haemophilus influenzae (NTHi). Protein D-containing pneumococcal conjugate vaccine PHiD-CV (Synflorix, GSK Vaccines) elicits robust immune responses against protein D. However, the phase III Clinical Otitis Media and PneumoniA Study (COMPAS), assessing PHiD-CV efficacy against various pneumococcal diseases, was not powered to demonstrate efficacy against NTHi; only trends of protective efficacy against NTHi AOM in children were shown...
July 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28562283/effectiveness-of-tympanostomy-tubes-for-otitis-media-a-meta-analysis
#9
REVIEW
Dale W Steele, Gaelen P Adam, Mengyang Di, Christopher H Halladay, Ethan M Balk, Thomas A Trikalinos
CONTEXT: Tympanostomy tube placement is the most common ambulatory surgery performed on children in the United States. OBJECTIVES: The goal of this study was to synthesize evidence for the effectiveness of tympanostomy tubes in children with chronic otitis media with effusion and recurrent acute otitis media. DATA SOURCES: Searches were conducted in Medline, the Cochrane Central Trials Registry and Cochrane Database of Systematic Reviews, Embase, and the Cumulative Index to Nursing and Allied Health Literature...
May 16, 2017: Pediatrics
https://www.readbyqxmd.com/read/28549858/a-prospective-observational-cohort-study-to-assess-the-incidence-of-acute-otitis-media-among-children-0-5-years-of-age-in-southern-brazil
#10
Tatiana M Lanzieri, Clóvis Arns da Cunha, Rejane B Cunha, D Fermin Arguello, Raghavendra Devadiga, Nervo Sanchez, Eduardo Ortega Barria
OBJECTIVES: To estimate acute otitis media incidence among young children and impact on quality of life of parents/caregivers in a southern Brazilian city. METHODS: Prospective cohort study including children 0-5 years of age registered at a private pediatric practice. Acute otitis media episodes diagnosed by a pediatrician and impact on quality of life of parents/caregivers were assessed during a 12-month follow-up. RESULTS: During September 2008-March 2010, of 1,136 children enrolled in the study, 1074 (95%) were followed: 55...
May 23, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28535362/tympanostomy-tube-placement-vs-medical-management-for-recurrent-acute-otitis-media-in-tricare-insured-children
#11
Nikhila Raol, Meesha Sharma, Emily F Boss, Wei Jiang, John W Scott, Peter Learn, Joel S Weissman
Objective To compare number of infections and health care utilization in children insured by TRICARE with recurrent acute otitis media (RAOM) managed surgically with tympanostomy tube (TT) placement compared with those managed medically. Study Design Retrospective matched cohort study. Setting TRICARE claims database from 2006 to 2010. Subjects and Methods We matched TRICARE beneficiaries ≤5 years of age diagnosed with RAOM who underwent TT placement with those managed medically using 1:1 coarsened-exact matching on age, sex, race, sponsor rank, and region...
May 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28514373/-acute-otitis-media-in-the-children-etiology-and-the-problems-of-antibacterial-therapy
#12
REVIEW
I N Protasova, O V Per'yanova, T S Podgrushnaya
The objective of the present review was to summarize the currently available literature data on etiology of acute otitis media in the children, the role of biofilms in the development of this pathology, and sensitivity of its principal causative factors to various antibiotic medications. The secondary objective was to elaborate the practical guidelines for the prevention of acute otitis media in the children.
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/28491218/bacterial-agents-of-the-discharging-middle-ear-among-children-seen-at-the-university-of-nigeria-teaching-hospital-enugu
#13
Gideon Chukwudalu Ilechukwu, Chioma Azuka Ilechukwu, Agozie Chukwunedum Ubesie, Ijeoma Okoroafor, Basil Chukwuemeka Ezeanolue, Ngozi Chinyelu Ojinnaka
INTRODUCTION: Discharging middle ear continues to be one of the commonest problems seen in the developing world. There is an ever growing need to carry out studies periodically to determine the common bacterial agents responsible for discharging otitis media and their antibiotic sensitivity especially in set-ups characterized with minimal laboratory services. The study sought to determine the common bacterial agents causing discharging middle ear among children presenting at the University of Nigeria Teaching Hospital, Enugu and their sensitivity to the commonly available antibiotics...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28486675/short-course-versus-long-course-oral-antibiotic-treatment-for-infections-treated-in-outpatient-settings-a-review-of-systematic-reviews
#14
Elizabeth E Dawson-Hahn, Sharon Mickan, Igho Onakpoya, Nia Roberts, Matthew Kronman, Chris C Butler, Matthew J Thompson
Purpose.: To summarize the evidence comparing the effectiveness of short and long courses of oral antibiotics for infections treated in outpatient settings. Methods.: We identified systematic reviews of randomized controlled trials for children and adults with bacterial infections treated in outpatient settings from Medline, Embase, CINAHL, Cochrane Database of Systematic Reviews and The Database of Review of Effects. Data were extracted on the primary outcome of clinical resolution and secondary outcomes...
May 9, 2017: Family Practice
https://www.readbyqxmd.com/read/28483250/monophosphoryl-lipid-a-enhances-nontypeable-haemophilus-influenzae-specific-mucosal-and-systemic-immune-responses-by-intranasal-immunization
#15
Taro Iwasaki, Takashi Hirano, Satoru Kodama, Yoshinori Kadowaki, Munehito Moriyama, Toshiaki Kawano, Masashi Suzuki
OBJECTIVE: Acute otitis media (AOM) is one of the most common infectious diseases in children. Nontypeable Haemophilus influenzae (NTHi) is Gram-negative bacteria that are considered major pathogens of AOM and respiratory tract infections. In this study, we used monophosphoryl lipid A (MPL), a toll-like receptor (TLR) 4 agonist, as an adjuvant to induce mucosal immune responses against NTHi to enhance bacterial clearance from the nasopharynx. METHODS: Mice were administered 10 μg outer membrane protein (OMP) from NTHi and 0, 10, or 20 μg MPL intranasally once a week for 3 weeks...
June 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28477429/higher-serum-25-oh-d-concentration-is-associated-with-lower-risk-of-chronic-otitis-media-with-effusion-a-case-control-study
#16
Rebecca E Walker, Jim Bartley, Carlos A Camargo, David Flint, John M D Thompson, Edwin A Mitchell
AIM: Vitamin D supplementation and higher 25(OH)-vitamin D concentration are associated with reduced risk of acute respiratory infection. This study examined whether there is a similar association between higher serum 25(OH)D concentration and lower risk of chronic otitis media with effusion (COME). METHODS: In a case-control study, serum 25(OH)D concentration in children referred for tympanostomy tube placement for COME (n=178) was compared to that of healthy children randomly sampled from primary care practices (n=179)...
May 6, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28468135/radiological-imaging-of-rare-intracranial-complications-secondary-to-otitis-media-and-mastoiditis
#17
Gülen Burakgazi, Hanifi Bayaroğullari, Fatma Öztürk, Cengiz Arli, Vicdan Köksaldi Motor, Rasim Yanmaz, Nesrin Atci
Acute otitis media used to cause fatal results because of its intracranial complications before the introduction of potent and effective antibiotics. After the introduction of antibiotics, complications have started to be observed more frequently as a result of chronic otitis media and especially in children. Because clinical findings changed and became indistinct, the diagnosis of otitis and mastoiditis has been made occasionally with imaging findings only after complications occurred. Multidetector computed tomography and magnetic resonance imaging are efficient and sufficient methods in the rapid diagnosis and should be immediately referred methods...
May 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28460599/the-human-otitis-media-with-effusion-a-numerical-based-study
#18
B Areias, M P L Parente, C Santos, F Gentil, R M Natal Jorge
Otitis media is a group of inflammatory diseases of the middle ear. Acute otitis media and otitis media with effusion (OME) are its two main types of manifestation. Otitis media is common in children and can result in structural alterations in the middle ear which will lead to hearing losses. This work studies the effects of an OME on the sound transmission from the external auditory meatus to the inner ear. The finite element method was applied on the present biomechanical study. The numerical model used in this work was built based on the geometrical information obtained from The visible ear project...
July 2017: Computer Methods in Biomechanics and Biomedical Engineering
https://www.readbyqxmd.com/read/28441829/-primary-ciliary-dyskinesia-with-hydin-gene-mutations-in-a-child-and-literature-review
#19
L L Chen, Y G Yang, J Z Wu, X R Chen
Objective: To review children's primary ciliary dyskinesia (PCD) in the pathogenesis, clinical manifestation, diagnosis and treatment. Method: To summarize and analyze the clinical data of a patient who was admitted to the first affiliated hospital of Xiamen University with primary ciliary dyskinesia in April 2014 while referring to related literature. Result: An 11 years old boy, weighting about 22 kg, had a course of more than 10 years with repeated cough, stuffy and runny nose shortly after the birth. Examinations after admission to hospital showed that he presented with visible clubbing, bilateral paranasal sinus area tenderness, pharynx posterior wall with visible yellow pussy stuff drip and bilateral lung had scattered wet rales...
April 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28438923/reduced-concentration-clavulanate-for-young-children-with-acute-otitis-media
#20
Alejandro Hoberman, Jack L Paradise, Howard E Rockette, Jong-Hyeon Jeong, Diana H Kearney, Sonika Bhatnagar, Timothy R Shope, Gysella Muñiz, Judith M Martin, Marcia Kurs-Lasky, MaryAnn Haralam, Marcia A Pope, Jennifer P Nagg, Wenchen Zhao, Mohammad Kowser Miah, Jan Beumer, Raman Venkataramanan, Nader Shaikh
Amoxicillin-clavulanate (A/C) is currently the most effective oral antimicrobial in treating children with acute otitis media (AOM), but the standard dosage of 90 mg amoxicillin/6.4 mg clavulanate/kg of body weight/day commonly causes diarrhea. We examined whether an A/C formulation containing lower concentrations of clavulanate would result in less diarrhea while maintaining plasma levels of amoxicillin and clavulanate adequate to eradicate middle-ear pathogens and to achieve clinical success. We conducted an open-label study in children with AOM who were 6 to 23 months of age...
July 2017: Antimicrobial Agents and Chemotherapy
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