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Acute otitis media in children

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https://www.readbyqxmd.com/read/28441829/-primary-ciliary-dyskinesia-with-hydin-gene-mutations-in-a-child-and-literature-review
#1
L L Chen, Y G Yang, J Z Wu, X R Chen
Objective: To review children's primary ciliary dyskinesia (PCD) in the pathogenesis, clinical manifestation, diagnosis and treatment. Method: To summarize and analyze the clinical data of a patient who was admitted to the first affiliated hospital of Xiamen University with primary ciliary dyskinesia in April 2014 while referring to related literature. Result: An 11 years old boy, weighting about 22 kg, had a course of more than 10 years with repeated cough, stuffy and runny nose shortly after the birth. Examinations after admission to hospital showed that he presented with visible clubbing, bilateral paranasal sinus area tenderness, pharynx posterior wall with visible yellow pussy stuff drip and bilateral lung had scattered wet rales...
April 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28438923/reduced-concentration-clavulanate-for-young-children-with-acute-otitis-media
#2
Alejandro Hoberman, Jack L Paradise, Howard E Rockette, Jong-Hyeon Jeong, Diana H Kearney, Sonika Bhatnagar, Timothy R Shope, Gysella Muñiz, Judith M Martin, Marcia Kurs-Lasky, Mary Ann Haralam, Marcia A Pope, Jennifer P Nagg, Wenchen Zhao, Mohammad Kowser Miah, Jan Beumer, Raman Venkataramanan, Nader Shaikh
Amoxicillin/clavulanate (A/C), is currently the most effective oral antimicrobial in treating children with acute otitis media (AOM), but standard dosage of 90/6.4 mg/kg/day commonly causes diarrhea. We examined whether an A/C formulation containing lower concentrations of clavulanate would result in less diarrhea, while maintaining plasma levels of amoxicillin and clavulanate adequate to eradicate middle-ear pathogens and achieve clinical success. We conducted an open-label study in children aged 6 to 23 months with AOM...
April 24, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28412081/nasopharyngeal-polymicrobial-colonization-during-health-viral-upper-respiratory-infection-and-upper-respiratory-bacterial-infection
#3
Qingfu Xu, Jareth Wischmeyer, Eduardo Gonzalez, Michael E Pichichero
OBJECTIVES: We sought to understand how polymicrobial colonization varies during health, viral upper respiratory infection (URI) and acute upper respiratory bacterial infection to understand differences in infection-prone vs. non-prone patients. METHODS: Nasopharyngeal (NP) samples were collected from 74 acute otitis media (AOM) infection-prone and 754 non-prone children during 2094 healthy visits, 673 viral URI visits and 631 AOM visits. Three otopathogens Streptococcus pneumoniae (Spn), Nontypeable Haemophilus influenzae (NTHi), and Moraxella catarrhalis (Mcat) were identified by culture...
April 13, 2017: Journal of Infection
https://www.readbyqxmd.com/read/28404603/clinical-failure-is-more-common-in-young-children-with-acute-otitis-media-who-receive-a-short-course-of-antibiotics-compared-with-standard-duration
#4
Roderick P Venekamp, Anne G M Schilder
No abstract text is available yet for this article.
April 12, 2017: Evidence-based Medicine
https://www.readbyqxmd.com/read/28403045/polymorphisms-of-mannose-binding-lectin-and-toll-like-receptors-2-3-4-7-and-8-and-the-risk-of-respiratory-infections-and-acute-otitis-media-in-children
#5
Laura Toivonen, Juho Vuononvirta, Jussi Mertsola, Matti Waris, Qiushui He, Ville Peltola
BACKGROUND: Mannose-binding lectin (MBL) and toll-like receptors (TLRs) are important components of the innate immune system. We assessed the susceptibility of children with genetic variants in these factors to respiratory infections, rhinovirus infections and acute otitis media. METHODS: In a prospective cohort study, blood samples from 381 Finnish children were analyzed for polymorphisms in MBL2 at codons 52, 54 and 57, TLR2 Arg753Gln, TLR3 Leu412Phe, TLR4 Asp299Gly, TLR7 Gln11Leu and TLR8 Leu651Leu...
May 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28390611/the-use-of-practice-guidelines-in-the-management-of-pediatric-cases-of-acute-otitis-media-in-amman-jordan
#6
Lubna Khreesha, Ali Bacharouch, R Alexander Blackwood, Mohammed Alkhoujah, Mohamad R Issa
OBJECTIVES: The widespread emergence of antimicrobial resistance has led many healthcare institutions to adopt more conservative antibiotic prescription practice guidelines for the treatment of acute otitis media (AOM). Little is known about the awareness and use of such guidelines by physicians in Jordan. Our aim was to pilot an anonymous survey instrument that would assess AOM treatment trends as well as awareness of and adherence to practice guidelines in Amman. By qualitatively assessing the management of AOM we could illuminate possible disparities in treatment trends, evaluate variability in practice guideline adherence, and help focus efforts of future educational programs that pertain to pediatric AOM management...
May 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28382124/frequency-of-serous-otitis-media-in-children-without-otolaryngological-symptoms
#7
Murat Kocyigit, Safiye Giran Ortekin, Taliye Cakabay, Guven Ozkaya, Selin Ustun Bezgin, Mustafa Kemal Adali
Introduction Otitis media with effusion is the fluid in the middle ear with no signs or symptoms of acute ear infection. Objective This study aims to research the frequency of serous otitis media in patients referred to the pediatric clinic between 3-16 years of age without any active ear, nose, and throat complaints. Methods This study included 589 children patients (280 boys, 309 girls; mean age: 9.42; range 3-16) who were administered to the pediatric clinic without otolaryngologic complaints. Patients underwent examination with flexible nasopharyngoscopy for adenoid hypertrophy...
April 2017: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/28372534/panel-7-otitis-media-treatment-and-complications
#8
Anne G M Schilder, Tal Marom, Mahmood F Bhutta, Margaretha L Casselbrant, Harvey Coates, Marie Gisselsson-Solén, Amanda J Hall, Paola Marchisio, Aino Ruohola, Roderick P Venekamp, Ellen M Mandel
Objective We aimed to summarize key articles published between 2011 and 2015 on the treatment of (recurrent) acute otitis media, otitis media with effusion, tympanostomy tube otorrhea, chronic suppurative otitis media and complications of otitis media, and their implications for clinical practice. Data Sources PubMed, Ovid Medline, the Cochrane Library, and Clinical Evidence (BMJ Publishing). Review Methods All types of articles related to otitis media treatment and complications between June 2011 and March 2015 were identified...
April 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28372531/panel-1-epidemiology-and-diagnosis
#9
Preben Homøe, Kari Kværner, Janet R Casey, Roger A M J Damoiseaux, Thijs M A van Dongen, Hasantha Gunasekera, Ramon G Jensen, Ellen Kvestad, Peter S Morris, Heather M Weinreich
Objective To create a literature review between 2011 and June 1, 2015, on advances in otitis media (OM) epidemiology and diagnosis (including relevant audiology studies). Data Sources Electronic search engines (PubMed, EMBASE, and Cochrane Library) with a predefined search strategy. Review Methods Articles with appropriate epidemiologic methodology for OM, including acute mastoiditis and eustachian tube dysfunction. Items included OM worldwide and in high-risk populations, OM-related hearing loss, news in OM diagnostics, prenatal risk factors and comorbidities, postnatal risk factors, genetics, microbiological epidemiology, guidelines, and quality of life...
April 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28372529/panel-4-report-of-the-microbiology-panel
#10
Stephen J Barenkamp, Tasnee Chonmaitree, Anders P Hakansson, Terho Heikkinen, Samantha King, Johanna Nokso-Koivisto, Laura A Novotny, Janak A Patel, Melinda Pettigrew, W Edward Swords
Objective To perform a comprehensive review of the literature from July 2011 until June 2015 on the virology and bacteriology of otitis media in children. Data Sources PubMed database of the National Library of Medicine. Review Methods Two subpanels comprising experts in the virology and bacteriology of otitis media were created. Each panel reviewed the relevant literature in the fields of virology and bacteriology and generated draft reviews. These initial reviews were distributed to all panel members prior to meeting together at the Post-symposium Research Conference of the 18th International Symposium on Recent Advances in Otitis Media, National Harbor, Maryland, in June 2015...
April 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28368738/efficacy-of-10-valent-pneumococcal-non-typeable-haemophilus-influenzae-protein-d-conjugate-vaccine-against-acute-otitis-media-and-nasopharyngeal-carriage-in-panamanian-children-a-randomized-controlled-trial
#11
Xavier Sáez-Llorens, Stella Rowley, Digna Wong, Mirna Rodríguez, Arlene Calvo, Marisol Troitiño, Albino Salas, Vielka Vega, Maria Mercedes Castrejón, Patricia Lommel, Thierry G Pascal, William P Hausdorff, Dorota Borys, Javier Ruiz-Guiñazú, Eduardo Ortega-Barría, Juan Pablo Yarzabal, Lode Schuerman
We previously reported 10-valent pneumococcal non-typeable Haemophilus influenzae (NTHi) protein D conjugate vaccine (PHiD-CV) efficacy in a double-blind randomized trial (ClinicalTrials.gov: NCT00466947) against various diseases, including acute otitis media (AOM). Here, we provide further analyses. In the Panamanian subset, 7,359 children were randomized (1:1) to receive PHiD-CV or control vaccine at age 2/4/6 and 15-18 months. Of these, 2,000 had nasopharyngeal swabs collected. AOM cases were captured when parents sought medical attention for children with AOM symptoms; surveillance was enhanced approximately 2 y into the study through regular telephone calls or home visits by study personnel, who advised parents to visit the clinic if their child had AOM symptoms...
February 25, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28357413/next-generation-sequencing-combined-with-specific-pcr-assays-to-determine-the-bacterial-16s-rrna-gene-profiles-of-middle-ear-fluid-collected-from-children-with-acute-otitis-media
#12
Saara Sillanpää, Lenka Kramna, Sami Oikarinen, Markku Sipilä, Markus Rautiainen, Janne Aittoniemi, Jussi Laranne, Heikki Hyöty, Ondrej Cinek
The aim of the study was to analyze the bacteriome of acute otitis media with a novel modification of next-generation sequencing techniques. Outpatient children with acute otitis media were enrolled in the study, and middle ear fluids were collected during 90 episodes from 79 subjects aged 5 to 42 months (median age, 19 months). The bacteriome profiles of middle ear fluid samples were determined by a nested-PCR amplification of the 16S rRNA gene (V4 region), followed by mass sequencing. The profiling results were compared to the results of specific PCR assays targeting selected prevalent pathogens...
March 2017: MSphere
https://www.readbyqxmd.com/read/28349737/pediatric-acute-otitis-media-in-the-era-of-pneumococcal-vaccination
#13
Kareem O Tawfik, Stacey L Ishman, Mekibib Altaye, Jareen Meinzen-Derr, Daniel I Choo
Objectives (1) Describe longitudinal trends in annual prevalence of hospital admission for pediatric acute otitis media (AOM) and complications of AOM (CAOM) since introduction of pneumococcal vaccination in 2000 and (2) describe the longitudinal trend of prevalence of hospital admission for pneumococcal meningitis in children with AOM-related diagnoses in the postvaccination era. Study Design Retrospective analysis of Kids' Inpatient Database from 2000 to 2012. Setting Community, nonrehabilitation hospitals...
March 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28340091/effect-of-antimicrobial-treatment-on-the-resolution-of-middle-ear-effusion-after-acute-otitis-media
#14
Aino Ruohola, Miia K Laine, Paula A Tähtinen
Background.: Acute otitis media (AOM) induces middle-ear effusion (MEE), which affects hearing. The effect of antimicrobial treatment on the resolution of MEE is controversial, and the factors that affect resolution are unknown. Methods.: We studied the effect of antimicrobial treatment on the time to the resolution of MEE as a secondary objective in our randomized double-blind placebo-controlled trial. Children aged 6 to 35 months with stringently diagnosed AOM were allocated to receive amoxicillin-clavulanate (161 patients) or placebo (158 patients) for 7 days and closely followed for 3 months...
March 16, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28338813/antibiotic-prescribing-for-acute-respiratory-infections-in-children-in-jordan
#15
Mera A Ababneh, Sayer I Al-Azzam, Rawan Ababneh, Abeer M Rababa'h, Saddam Al Demour
Background: Most acute respiratory infections (ARIs) in children are due to viral etiology; however, over-prescribing of antibiotics for ARIs is common. The aim of this investigation was to identify antibiotic prescribing prevalence for children with ARIs and to identify predictors of broad-spectrum antibiotic prescribing. Methods: This was a prospective cross sectional study in a sample of ambulatory care settings in Jordan. Children (<18 years) presenting with ARIs were assessed in terms of patient's demographics, antibiotic prescription and clinical diagnosis...
March 1, 2017: International Health
https://www.readbyqxmd.com/read/28330713/acute-otitis-media-in-children-a-vaccine-preventable-disease
#16
EDITORIAL
Marco Aurélio Palazzi Sáfadi, Daniel Jarovsky
No abstract text is available yet for this article.
February 28, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28329388/healthcare-claims-data-an-underutilized-tool-for-pediatric-outpatient-antimicrobial-stewardship
#17
Joshua R Watson, Ling Wang, Jennifer Klima, Melissa Moore-Clingenpeel, Sean Gleeson, Kelly Kelleher, Preeti Jaggi
Background: Healthcare claims are under-utilized to identify factors associated with high outpatient antibiotic use. Methods: We evaluated ambulatory encounter claims of Medicaid-insured children in 34 Ohio counties in 2014. 1) Rates of total antibiotic and azithromycin prescriptions dispensed were determined by county of patient residence. 2) Standardized treatment rates by county were estimated for uncomplicated upper respiratory tract encounters (acute otitis media, pharyngitis, sinusitis, presumed viral infection) after adjusting for patient age and encounter provider type...
March 9, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28289114/parents-expectations-and-experiences-of-antibiotics-for-acute-respiratory-infections-in-primary-care
#18
Peter D Coxeter, Chris Del Mar, Tammy C Hoffmann
PURPOSE: Primary care visits for children with acute respiratory infections frequently result in antibiotic prescriptions, although antibiotics have limited benefits for common acute respiratory infections and can cause harms, including antibiotic resistance. Parental demands are often blamed for antibiotic prescription. We aimed to explore parents' beliefs about antibiotic necessity, quantify their expectations of antibiotic benefit, and report experiences of other management options and exposure to and preferences for shared decision making...
March 2017: Annals of Family Medicine
https://www.readbyqxmd.com/read/28283791/balloon-eustachian-tuboplasty-in-children
#19
A Leichtle, D Hollfelder, B Wollenberg, K-L Bruchhage
Endonasal ballon dilatation of the Eustachian tube (BET) is a promising treatment for Eustachian tube dysfunction with encouraging results over the last years in adults. In addition, in children, single studies demonstrated promising results, but revealed the necessity for broader and additional studies. Our retrospective analysis presents outcomes with BET in children with chronic obstructive dysfunction of the Eustachian tube, showing resistance to the conventional therapy after adenotomy with paracentesis or grommets (ventilation tubes)...
March 10, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28277413/community-primary-care-provider-preferences-for-emergency-department-follow-up-recommendations-a-regional-study
#20
Marissa A Hendrickson, Eta Obeya, Andrew R Wey, Philippe R Gaillard
BACKGROUND: Children who present to emergency departments (EDs) for care are frequently advised to follow up with their primary care providers (PCPs) after discharge; little is known about whether PCPs agree that follow-up advised by EDs is appropriate for their patients. OBJECTIVES: The aims of this study were to determine PCP preferences for follow-up recommendations given to their pediatric patients at the time of ED visits and to compare these preferences to reported emergency medicine provider (EMP) practice...
March 9, 2017: Pediatric Emergency Care
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