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https://www.readbyqxmd.com/read/28535408/differences-in-clinical-and-cognitive-variables-in-seasonal-affective-disorder-compared-to-depressive-related-disorders-evidence-from-a-population-based-study-in-finland
#1
I Morales-Muñoz, S Koskinen, T Partonen
BACKGROUND: Seasonal affective disorder (SAD) is a type of depression with seasonal pattern. Although it involves some idiosyncratic symptoms, it can overlap with other depressive disorders such as major depressive disorder (MDD) or dysthymia. We aimed to characterize the differences in specific cognitive and clinical symptoms between SAD and depressive-related disorders. METHODS: In total, 4554 Finnish subjects from the population-based Health 2011 Survey were interviewed with the Munich version of Composite International Diagnostic Interview (M-CIDI) and filled in the Seasonal Pattern Assessment Questionnaire (SPAQ)...
March 28, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28527318/activating-analytic-thinking-enhances-the-value-given-to-individualizing-moral-foundations
#2
Onurcan Yilmaz, S Adil Saribay
Two central debates within Moral Foundations Theory concern (1) which moral foundations are core and (2) how conflict between ideological camps stemming from valuing different moral foundations can be resolved. Previous studies have attempted to answer the first question by imposing cognitive load on participants to direct them toward intuitive and automatic thought. However, this method has limitations and has produced mixed findings. In the present research, in two experiments, instead of directing participants toward intuitive thought, we tested the effects of activating high-effort, analytic thought on participants' moral foundations...
May 17, 2017: Cognition
https://www.readbyqxmd.com/read/28527257/-polyclonal-antibodies-against-recombinant-dengue-virus-ns3-protein
#3
Liliana Morales, Myriam L Velandia, María Angélica Calderon, Jaime E Castellanos, Jacqueline Chaparro-Olaya
INTRODUCTION: Dengue is a disease caused by one of four serotypes of the dengue virus (DENV) and is endemic in approximately 130 countries. The incidence of dengue has increased dramatically in recent decades, as well as the frequency and magnitude of outbreaks. Despite all efforts, there are no prophylactic or therapeutic treatments for the disease. Accordingly, research on the processes governing the DENV infection cycle is essential to develop vaccines or antiviral therapies. One of themost attractive DENV molecules to investigate is nonstructural protein 3 (NS3), which is essential for viral replication and a major immune target for infection...
January 24, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/28526615/lung-inflammation-after-bleomycin-treatment-in-mice-selection-of-an-accurate-normalization-strategy-for-gene-expression-analysis-in-an-ex-vivo-and-in-vitro-model
#4
Veronica Della Latta, Manuela Cabiati, Silvia Burchielli, Giada Frenzilli, Margherita Bernardeschi, Antonella Cecchettini, Federica Viglione, Maria-Aurora Morales, Silvia Del Ry
Pulmonary fibrosis (PF) is the most common and aggressive interstitial lung disease, characterized by a patchy development of fibrosis leading to progressive destruction of the normal lung architecture which is preceded by an inflammatory process. Gene expression studies are important to understand the development of PF but the accuracy and reproducibility of Real-Time PCR depend on appropriate normalization strategies. This study aimed to analyze the expression variability of eight commonly used reference genes during the initial inflammatory phase of bleomycin-induced PF in a mouse model and to verify whether the selected reference genes could be applied to an in-vitro model of BLM-treated primary murine lung fibroblasts...
May 16, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28523560/stem-cell-technology-for-epi-genetic-brain-disorders
#5
Renzo J M Riemens, Edilene S Soares, Manel Esteller, Raul Delgado-Morales
Despite the enormous efforts of the scientific community over the years, effective therapeutics for many (epi)genetic brain disorders remain unidentified. The common and persistent failures to translate preclinical findings into clinical success are partially attributed to the limited efficiency of current disease models. Although animal and cellular models have substantially improved our knowledge of the pathological processes involved in these disorders, human brain research has generally been hampered by a lack of satisfactory humanized model systems...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28522299/most-advisable-strategy-in-search-of-asymptomatic-target-organ-damage-in-hypertensive-patients
#6
J Abellán-Huerta, L Prieto-Valiente, L Consuegra-Sánchez, S Montoro-García, A B Salguero-Merino, R Morales-López, J Abellán-Alemán, F Soria-Arcos
OBJECTIVE: To evaluate the diagnostic potential of seven examinations in order to define the most suitable strategy for target organ damage (TOD) search in hypertensive patients. METHODS: This is a descriptive, cross-sectional study. 153 consecutive treated and essential hypertensive patients were enrolled. Patients with established cardiovascular or chronic renal disease (stage ≥4) were excluded. TOD search was assessed by: glomerular filtration rate (GFR), albumin/creatinine ratio (ACR), electrocardiogram (ECG), echocardiogram (ECO), ankle-brachial index (ABI), pulse wave velocity (PWV), and carotid ultrasound (intima media thickness and presence of plaques)...
May 15, 2017: Hipertensión y Riesgo Vascular
https://www.readbyqxmd.com/read/28521281/functional-connectivity-in-incarcerated-male-adolescents-with-psychopathic-traits
#7
Sandra Thijssen, Kent A Kiehl
The present study examined the association between psychopathic traits and functional connectivity in 177 incarcerated male adolescents. We hypothesized that psychopathic symptoms would be associated with functional connectivity within networks encompassing limbic and paralimbic regions, such as the default mode (DMN), salience networks (SN), and executive control network (ECN). The present sample was drawn from the Southwest Advanced Neuroimaging Cohort, Youth sample, and from research at a youth detention facility in Wisconsin...
May 11, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28516209/foreign-language-effect-and-psychological-distance
#8
Hong Im Shin, Juyoung Kim
Does using a foreign language result in forming different moral decisions than using our mother tongue? Two studies were conducted to investigate whether there is a relationship between foreign language effects (differences between native vs. foreign language conditions) and psychological distance. Study 1 tested four moral dilemmas adapted from Greene et al. (Cognition 107: 1144-1155, 2008). Non-fluent Korean-English bilingual participants (N = 161) indicated decisions regarding four moral dilemmas in either Korean or English languages...
May 17, 2017: Journal of Psycholinguistic Research
https://www.readbyqxmd.com/read/28513968/the-views-of-ethics-committee-members-and-medical-researchers-on-the-return-of-individual-research-results-and-incidental-findings-ownership-issues-and-benefit-sharing-in-biobanking-research-in-a-south-indian-city
#9
Manjulika Vaz, Mario Vaz, Srinivasan K
The return of individual research results and incidental findings from biobanking research is a much debated ethical issue globally but has extensive relevance in India where the burden of out of pocket health care expenses is high for the majority. The views of 21 ethics committee (EC) members and 22 researchers from Bengaluru, India, concerning the ethics of biobanking research were sought through in-depth interviews using an unfolding case vignette with probes. A shared view among most was that individual research results which are 'actionable' or have 'clinical significance' should be returned to the sample contributors through their treating physicians...
May 17, 2017: Developing World Bioethics
https://www.readbyqxmd.com/read/28512859/exploring-daily-affective-changes-in-university-students-with-a-mindful-positive-reappraisal-intervention-a-daily-diary-randomized-controlled-trial
#10
Ekaterina Pogrebtsova, Jacqueline Craig, Alexandra Chris, Deirdre O'Shea, M Gloria González-Morales
Brief and cost-effective interventions focused on emotion regulation techniques can buffer against stress and foster positive functioning. Mindfulness and positive reappraisal are two techniques that can mutually enhance one another to promote well-being. However, research testing the effectiveness of interventions combining mindfulness and reappraisal is lacking. The current pilot examined the effect of a combined mindful-reappraisal intervention on daily affect in a 5-day diary study with 106 university students...
May 17, 2017: Stress and Health: Journal of the International Society for the Investigation of Stress
https://www.readbyqxmd.com/read/28508353/what-matters-when-judging-intentionality-moral-content-or-normative-status-testing-the-rational-scientist-model-of-the-side-effect
#11
C Papadopoulos, B K Hayes
Previous work has demonstrated a "side-effect effect," such that intentionality is more likely to be attributed to agents who bring about negatively valenced as opposed to positively valenced side effects. The rational-scientist model explains this by suggesting that norm-violating side effects are more informative for inferring intentionality than norm-conforming side effects. In the present study we reexamined this account, addressing limitations of previous empirical tests (e.g., Uttich & Lombrozo, Cognition 116: 87-100, 2010)...
May 15, 2017: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/28507444/antibodies-against-glutamic-acid-decarboxylase-and-indices-of-insulin-resistance-and-insulin-secretion-in-nondiabetic-adults-a-cross-sectional-study
#12
Carlos O Mendivil, Freddy Jk Toloza, Maria L Ricardo-Silgado, Martha C Morales-Álvarez, Jose O Mantilla-Rivas, Jairo A Pinzón-Cortés, Hernán N Lemus
BACKGROUND: Autoimmunity against insulin-producing beta cells from pancreatic islets is a common phenomenon in type 1 diabetes and latent autoimmune diabetes in adults. Some reports have also related beta-cell autoimmunity to insulin resistance (IR) in type 2 diabetes. However, the extent to which autoimmunity against components of beta cells is present and relates to IR and insulin secretion in nondiabetic adults is uncertain. AIM: To explore the association between antibodies against glutamic acid decarboxylase (GADA), a major antigen from beta cells, and indices of whole-body IR and beta-cell capacity/insulin secretion in adults who do not have diabetes...
2017: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/28506923/core-social-and-moral-disgust-are-bounded-a-review-on-cognitive-and-neural-bases-of-repugnance-in-clinical-disorders
#13
REVIEW
Carmelo M Vicario, Robert D Rafal, Davide Martino, Alessio Avenanti
Disgust is a multifaceted experience that might affect several aspects of life. Here, we reviewed research on neurological and psychiatric disorders that are characterized by abnormal disgust processing to test the hypothesis of a shared neurocognitive architecture in the representation of three disgust domains: i) personal experience of 'core disgust'; ii) social disgust, i.e., motor and vocal expressions of disgust; iii) moral disgust, i.e., sensitivity to ethical violations. Our analysis provides some support to the shared neurocognitive hypothesis and suggests that the insula might be the "hub" structure linking the three domains of disgust sensitivity, while other brain regions may subserve specific facets of the multidimensional experience...
May 12, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28497721/scale-effects-in-moral-relevance-assessment
#14
Jonas Nagel, Andrej Rybak
Research on moral judgment often employs bipolar rating scales to assess whether the difference between two contrasted options is judged to be morally relevant. We give an account of how different numbers of response options provided on such scales (odd vs. even) change the meaning of the test question by communicating different implicit presuppositions. We demonstrate experimentally that these changes can qualitatively affect the moral relevance judgments that subjects express in response to a given judgment problem...
March 2017: Experimental Psychology
https://www.readbyqxmd.com/read/28497719/moral-hindsight
#15
Nadine Fleischhut, Björn Meder, Gerd Gigerenzer
How are judgments in moral dilemmas affected by uncertainty, as opposed to certainty? We tested the predictions of a consequentialist and deontological account using a hindsight paradigm. The key result is a hindsight effect in moral judgment. Participants in foresight, for whom the occurrence of negative side effects was uncertain, judged actions to be morally more permissible than participants in hindsight, who knew that negative side effects occurred. Conversely, when hindsight participants knew that no negative side effects occurred, they judged actions to be more permissible than participants in foresight...
March 2017: Experimental Psychology
https://www.readbyqxmd.com/read/28496421/the-positivity-bias-phenomenon-in-face-perception-given-different-information-on-ability
#16
Sasa Zhao, Yanhui Xiang, Jiushu Xie, Yanyan Ye, Tianfeng Li, Lei Mo
The negativity bias has been shown in many fields, including in face processing. We assume that this bias stems from the potential threat inlayed in the stimuli (e.g., negative moral behaviors) in previous studies. In the present study, we conducted one behavioral and one event-related potentials (ERPs) experiments to test whether the positivity bias rather than negativity bias will arise when participants process information whose negative aspect involves no threat, i.e., the ability information. In both experiments, participants first completed a valence rating (negative-to-positive) of neutral facial expressions...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28495558/acute-psychosocial-stress-and-everyday-moral-decision-making-in-young-healthy-men-the-impact-of-cortisol
#17
Nina Singer, Monika Sommer, Katrin Döhnel, Sandra Zänkert, Stefan Wüst, Brigitte M Kudielka
In everyday life, moral decisions must frequently be made under acute stress. Although there is increasing evidence that both stress and cortisol affect moral judgment and behavior as well as decision-making in various domains unrelated to morality, surprisingly few attempts have been made to explore the effects of stress on everyday moral decision-making. Therefore, in the present study, we exposed 50 young healthy men to the Trier Social Stress Test (TSST) or its non-stressful placebo version (PTSST). We investigated the impact of acute stress exposure and stress-related cortisol levels on decision-making, decision certainty, and emotions in 28 everyday moral conflict situations with altruistic versus egoistic response alternatives...
May 19, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28490345/post-2015-why-delay-to-seek-healthcare-perceptions-and-field-experiences-from-tb-healthcare-providers-in-northern-malawi-a-qualitative-study
#18
Nathan B W Chimbatata, Chang-Ming Zhou, Chikondi M Chimbatata, Biao Xu
BACKGROUND: Malawi is a low-income country with high Tuberculosis (TB) burden. TB diagnosis delay and untimely initiation of treatment is still a major problem in Malawi which could increase the risk of tuberculosis transmission in the communities. This study investigated factors related to the diagnostic delay of tuberculosis from TB healthcare providers in the northern region of Malawi. METHODS: Nine focus group discussions were conducted with 57 participants in total...
May 11, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28486837/distinct-effects-of-reminding-mortality-and-physical-pain-on-the-default-mode-activity-and-activity-underlying-self-reflection
#19
Zhenhao Shi, Shihui Han
Behavioral research suggests that reminding both mortality and negative affect influences self-related thoughts. Using functional MRI, we tested the hypothesis that reminders of mortality and physical pain decrease brain activity underlying self-related thoughts. Three groups of adults underwent priming procedures during which they answered questions pertaining to mortality, physical pain, or leisure time, respectively. Before and after priming, participants performed personality trait judgments on oneself or a celebrity, identified the font of words, or passively viewed a fixation...
May 9, 2017: Social Neuroscience
https://www.readbyqxmd.com/read/28486533/health-sciences-evidence-based-practice-questionnaire-hs-ebp-for-measuring-transprofessional-evidence-based-practice-creation-development-and-psychometric-validation
#20
Juan Carlos Fernández-Domínguez, Joan Ernest de Pedro-Gómez, José Miguel Morales-Asencio, Miquel Bennasar-Veny, Pedro Sastre-Fullana, Albert Sesé-Abad
INTRODUCTION: Most of the EBP measuring instruments available to date present limitations both in the operationalisation of the construct and also in the rigour of their psychometric development, as revealed in the literature review performed. The aim of this paper is to provide rigorous and adequate reliability and validity evidence of the scores of a new transdisciplinary psychometric tool, the Health Sciences Evidence-Based Practice (HS-EBP), for measuring the construct EBP in Health Sciences professionals...
2017: PloS One
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