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Christoph Zinner, David Morales-Alamo, Niels Ørtenblad, Filip J Larsen, Tomas A Schiffer, Sarah J Willis, Miriam Gelabert-Rebato, Mario Perez-Valera, Robert Boushel, Jose A L Calbet, Hans-Christer Holmberg
To elucidate the mechanisms underlying the differences in adaptation of arm and leg muscles to sprint training, over a period of 11 days 16 untrained men performed six sessions of 4-6 × 30-s all-out sprints (SIT) with the legs and arms, separately, with a 1-h interval of recovery. Limb-specific VO2peak, sprint performance (two 30-s Wingate tests with 4-min recovery), muscle efficiency and time-trial performance (TT, 5-min all-out) were assessed and biopsies from the m. vastus lateralis and m. triceps brachii taken before and after training...
2016: Frontiers in Physiology
Rafel Ramos, Xavier Albert, Joan Sala, Maria Garcia-Gil, Roberto Elosua, Jaume Marrugat, Anna Ponjoan, María Grau, Manel Morales, Antoni Rubió, Pedro Ortuño, Lia Alves-Cabratosa, Ruth Martí-Lluch
BACKGROUND: Diagnosis of unrecognized myocardial infarction (UMI) remains an open question in epidemiological and clinical studies, inhibiting effective secondary prevention of myocardial infarction. We aimed to determine the prevalence and incidence of Q-wave UMI in asymptomatic individuals aged 35 to 74years, and to ascertain the positive predictive value (PPV) of asymptomatic Q-wave to diagnose UMI. METHODS: Two population-based cross-sectional studies were conducted, in 2000 (with 10-year follow-up) and in 2005...
October 5, 2016: International Journal of Cardiology
Luzmercy Perez, Knashawn H Morales, Heather Klusaritz, Xiaoyan Han, Jingru Huang, Marisa Rogers, Ian M Bennett, Cynthia S Rand, Grace Ndicu, Andrea J Apter
BACKGROUND: Self-management of moderate/severe asthma depends upon patients' ability to: 1) navigate (access health care to obtain diagnoses and treatment), 2) use inhaled corticosteroids (ICS) properly, and 3) understand ICS function. OBJECTIVE: To test whether navigation skills (medication recall, knowledge of copay requirements ability to provide information needed for a medical visit about a persistent cough unresponsive to medication), are related to other self-management skills and to health literacy...
October 12, 2016: Journal of Allergy and Clinical Immunology
Rafael Morales-Barrera, Cristina Suárez, Ana Martínez de Castro, Fabricio Racca, Claudia Valverde, Xavier Maldonado, Juan Maria Bastaros, Juan Morote, Joan Carles
Bladder cancer is one of the leading causes of death in Europe and the United States. About 25% of patients with bladder cancer have advanced disease (muscle-invasive or metastatic disease) at presentation and are candidates for systemic chemotherapy. In the setting of metastatic disease, use of cisplatin-based regimens improves survival. However, despite initial high response rates, the responses are typically not durable leading to recurrence and death in the vast majority of these patients with median overall survival of 15months and a 5-year survival rate of ⩽10%...
October 1, 2016: Cancer Treatment Reviews
Stephan Steidl, Huiling Wang, Marco Ordonez, Shiliang Zhang, Marisela Morales
Converging evidence shows that ventral tegmental area (VTA) dopamine neurons receive laterodorsal tegmental nucleus (LDTg) cholinergic and glutamatergic inputs. To test the behavioral consequences of selectively driving the two sources of excitatory LDTg input to the VTA, channelrhodopsin-2 (ChR2) was expressed in LDTg cholinergic neurons of ChAT::Cre mice (ChAT-ChR2 mice) or in LDTg glutamatergic neurons of VGluT2::Cre mice (VGluT2-ChR2 mice). Mice were tested in a 3-chamber place preference apparatus where entry into a light-paired chamber resulted in VTA light stimulation of LDTg-cholinergic or LDTg-glutamatergic axons for the duration of a chamber stay...
October 14, 2016: European Journal of Neuroscience
Tasleem J Padamsee
The history of government action on HIV/AIDS has much to teach us about the dynamics and possibilities of US public health policy, but it has been insufficiently studied by social scientists of the epidemic. This article draws on a large set of original interviews with policy makers, thousands of news articles, and extensive documentation to reconstruct the history of three areas of debate and decision making about HIV prevention since 1990: needle exchange, HIV testing, and sex education for at-risk groups...
October 11, 2016: Journal of Health Politics, Policy and Law
Alyssa S Thomas, Taciano L Milfont, Michael C Gavin
Non-compliance with fishing regulations can undermine management effectiveness. Previous bivariate approaches were unable to untangle the complex mix of factors that may influence fishers' compliance decisions, including enforcement, moral norms, perceived legitimacy of regulations and the behaviour of others. We compared seven multivariate behavioural models of fisher compliance decisions using structural equation modeling. An online survey of over 300 recreational fishers tested the ability of each model to best predict their compliance with two fishing regulations (daily and size limits)...
2016: PloS One
Marta Villacieros, José Carlos Bermejo, Marisa Magaña, Invención Fernández-Quijano
: The purpose of this study was to analyze psychometric properties of the Spanish version of Attitudinal Beliefs Questionnaire about Suicidal Behavior CCCS-18 (Ruiz, Navarro-Ruiz, Torrente, & Rodríguez, 2005). The participants were 277 subjects, 81.2% (225) women and 18.8% (52) men. The average age was 39.95 years old (SD = 15.9). A confirmatory factor analysis was performed to test the adequacy of the four-factor model proposed by the authors. As a result it was obtained a three-factor model (χ2/df = 1...
October 11, 2016: Spanish Journal of Psychology
Víctor R Campos-García, Carlos A López-Morales, Eleuterio Benites-Zaragoza, Armando Jiménez-Miranda, Carlos E Espinosa-de la Garza, Daniel Herrera-Fernández, Jesús Padilla-Calderón, Néstor O Pérez, Luis F Flores-Ortiz, E Medina-Rivero
Complex pharmaceuticals are in demand of competent analytical methods able to analyze charge heterogeneity as a critical quality attribute (CQA), in compliance with current regulatory expectations. A notorious example is glatiramer acetate (GA), a complex polypeptide mixture useful for the treatment of relapsing-remitting multiple sclerosis. This pharmaceutical challenges the current state of analytical technology in terms of the capacity to study their constituent species. Thus, a strong cation exchange methodology was designed under the lifecycle approach to support the establishment of GA identity, trough the evaluation of its chromatographic profile, which acts as a charge heterogeneity fingerprint...
October 4, 2016: Journal of Pharmaceutical and Biomedical Analysis
María Teresa Sánchez-Ávila, Karla Lorena Chávez Caraza, Adrián Marcelo González Gil, Jaime Javier Cantú Pompa, Edgar Moreno Medrano, Luis Alonso Morales-Garza
BACKGROUND: Hydrogen breath tests (HBT) are used to confirm the diagnosis of carbohydrate intolerance or small intestinal bacterial overgrowth (SIBO). OBJECTIVE: Determine the existence of a correlation between the presence and intensity of symptoms experimented by the patient after the ingestion of a carbohydrate load and the test result. MATERIALS AND METHODS: This is an observational, retrospective and analytic study, in which all patients' files from year 2008 to 2014 containing a report of a HBT performed at Hospital San José TEC de Monterrey were revised...
July 2016: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
Marie-Noëlle Bélanger-Lévesque, Marc Dumas, Simon Blouin, Jean-Charles Pasquier
BACKGROUND: While spirituality is well described in end-of-life care literature, research on its place in the delivery room remains largely limited to mother-oriented qualitative studies focusing on life-threatening situations (e.g., high-risk pregnancies). Our aim was to compare mothers' and fathers' spirituality during childbirth. METHODS: A mixed methods questionnaire was developed from our childbirth-related spirituality categorization and distributed to all parents of newborns, 12-24 h postpartum, over 45 consecutive days...
September 30, 2016: BMC Pregnancy and Childbirth
Jorge Alberto Romero-Hernández, Araceli Amaya-Chávez, Patricia Balderas-Hernández, Gabriela Roa-Morales, Nelly González-Rivas, Miguel Ángel Balderas-Plata
In the present investigation, four macrophytes, namely, Typha latifolia (L.), Lemna minor (L.), Eichhornia crassipes (Mart.) Solms-Laubach and Miriophyllum aquaticum (Vell.) Verdc, were evaluated for their heavy metal (Cu, Pb, Hg and Zn) hyperaccumulation potential under laboratory conditions. Tolerance analyses were performed for 7 days of exposure at five different treatments of the metals mixture (Cu(+2), Hg(+2), Pb(+2) and Zn(+2)). The production of chlorophyll and carotenoids was determined at the end of each treatment...
August 11, 2016: International Journal of Phytoremediation
Clare B O'Donovan, Marianne C Walsh, Hannah Forster, Clara Woolhead, Carlos Celis-Morales, Rosalind Fallaize, Anna L Macready, Cyril F M Marsaux, Santiago Navas-Carretero, Rodrigo San-Cristobal, Silvia Kolossa, Christina Mavrogianni, Christina P Lambrinou, George Moschonis, Magdalena Godlewska, Agnieszka Surwillo, Jildau Bouwman, Keith Grimaldi, Iwona Traczyk, Christian A Drevon, Hannelore Daniel, Yannis Manios, J Alfredo Martinez, Wim H M Saris, Julie A Lovegrove, John C Mathers, Michael J Gibney, Lorraine Brennan, Eileen R Gibney
BACKGROUND: It is hypothesised that individuals with knowledge of their genetic risk are more likely to make health-promoting dietary and lifestyle changes. The present study aims to test this hypothesis using data from the Food4Me study. This was a 6-month Internet-based randomised controlled trial conducted across seven centres in Europe where individuals received either general healthy eating advice or varying levels of personalised nutrition advice. Participants who received genotype-based personalised advice were informed whether they had the risk (CT/TT) (n = 178) or non-risk (CC) (n = 141) alleles of the methylenetetrahydrofolate reductase (MTHFR) gene in relation to cardiovascular health and the importance of a sufficient intake of folate...
2016: Genes & Nutrition
Beatriz Parra, Jairo Lizarazo, Jorge A Jiménez-Arango, Andrés F Zea-Vera, Guillermo González-Manrique, José Vargas, Jorge A Angarita, Gonzalo Zuñiga, Reydmar Lopez-Gonzalez, Cindy L Beltran, Karen H Rizcala, Maria T Morales, Oscar Pacheco, Martha L Ospina, Anupama Kumar, David R Cornblath, Laura S Muñoz, Lyda Osorio, Paula Barreras, Carlos A Pardo
Background Zika virus (ZIKV) infection has been linked to the Guillain-Barré syndrome. From November 2015 through March 2016, clusters of cases of the Guillain-Barré syndrome were observed during the outbreak of ZIKV infection in Colombia. We characterized the clinical features of cases of Guillain-Barré syndrome in the context of this ZIKV infection outbreak and investigated their relationship with ZIKV infection. Methods A total of 68 patients with the Guillain-Barré syndrome at six Colombian hospitals were evaluated clinically, and virologic studies were completed for 42 of the patients...
October 5, 2016: New England Journal of Medicine
David S Oderberg
I explore the increasingly important issue of cooperation in immoral actions, particularly in connection with healthcare. Conscientious objection, especially as pertains to religious freedom in healthcare, has become a pressing issue in the light of the US Supreme Court judgement in Hobby Lobby Section 'Moral evaluation using the basic principles of cooperation' outlines a theory of cooperation inspired by Catholic moral theologians such as those cited by the court. The theory has independent plausibility and is at least worthy of serious consideration-in part because it is an instance of double-effect reasoning, which is also independently plausible despite its association with moral theology...
October 3, 2016: Journal of Medical Ethics
L Barón, K Fara, H Zapata-Carmona, L Zuñiga, M Kong, J Signorelli, E S Díaz, P Morales
In human spermatozoa, protein kinases have a role in the acrosome reaction (AR) induced by a variety of stimuli. However, there is disagreement or a lack of information regarding the role of protein kinases and phosphatases in the progesterone (P)-induced increase in intracellular calcium concentration ([Ca(2+) ]i ). In addition, there are no studies regarding the role of Ser/Thr and Tyr phosphatases and there are contradictory results regarding the role of Tyr kinases in the P-induced acrosome reaction. Here, we performed a simultaneous evaluation of the involvement of protein kinases and phosphatases in the P-induced acrosome reaction and in the P-induced calcium influx...
October 1, 2016: Andrology
Camellia Torabizadeh, Leyla Homayuni, Marzieh Moattari
BACKGROUND: Nurses are often faced with complex situations that made them to make ethical decisions; and to make such decisions, they need to possess the power of moral reasoning. Studies in Iran show that the majority of nursing students lack proper ethical development. Socratic teaching is a student-centered method which is strongly opposed to the lecturing method. OBJECTIVES: This study was conducted to evaluate the impacts of Socratic questioning on the moral reasoning of the nursing students...
September 30, 2016: Nursing Ethics
Alexa Gomez, Alexandra N Petrucci, Lauren Dance, Jessica Morales Valenzuela, Nicole Gibbs, Cara C Dahlhausen, Jessica R Villatoro, Russell F Frohardt, Fay A Guarraci
The present study was designed to test the effects of an acute, high dose of methylphenidate (MPH; trademarked as Ritalin) on sexual behavior in female Long-Evans rats. In Experiment 1, naturally cycling subjects in estrus were tested for partner preference 20 min after receiving an i.p. injection of MPH 10.0 mg/kg (n=8) or saline (n=7). During the partner-preference test, female subjects were given the choice to interact with a sexually active male stimulus or a sexually receptive female stimulus. Physical contact was limited by placing the stimulus animals behind a wire mesh during the no-contact phase of the test, whereas physical contact was not limited during the contact phase...
September 27, 2016: Pharmacology, Biochemistry, and Behavior
Daniel San-Juan, Dulce Anabel Espinoza López, Rafael Vázquez Gregorio, Carlos Trenado, Maricarmen Fernández-González Aragón, León Morales-Quezada, Axel Hernandez Ruiz, Flavio Hernandez-González, Alejandro Alcaraz-Guzmán, David J Anschel, Felipe Fregni
BACKGROUND: Transcranial direct current stimulation (tDCS) has been evaluated in medication refractory epilepsy patients. The results have been inconclusive and protocols have varied between studies. OBJECTIVE: To evaluate the safety and efficacy of two protocols of tDCS in adult patients with mesial temporal lobe epilepsy and hippocampal sclerosis (MTLE-HS). METHODS: This is a randomized placebo-controlled, double-blinded clinical trial, with 3 arms, 3 sessions, 5 sessions and placebo stimulation...
August 31, 2016: Brain Stimulation
José M Arreola-Guerra, Natalia Castelán, Adrián de Santiago, Adriana Arvizu, Norma Gonzalez-Tableros, Mayra López, Isaac Salcedo, Mario Vilatobá, Julio Granados, Luis E Morales-Buenrostro, Josefina Alberú
The aim of the present study was to describe the association of positive flow cross match (FXM) and C1q-SAB. Methods. In this observational, cross-sectional, and comparative study, patients included had negative AHG-CDC-XM and donor specific antibodies (DSA) and were tested with FXM. All pretransplant sera were tested with C1q-SAB assay. Results. A total of 50 donor/recipient evaluations were conducted; half of them had at least one C1q+ Ab (n = 26, 52%). Ten patients (20.0%) had DSA C1q+ Ab. Twenty-five (50%) FXMs were positive...
2016: Journal of Transplantation
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