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https://www.readbyqxmd.com/read/29785732/the-mental-representation-of-human-action
#1
Sydney Levine, Alan M Leslie, John Mikhail
Various theories of moral cognition posit that moral intuitions can be understood as the output of a computational process performed over structured mental representations of human action. We propose that action plan diagrams-"act trees"-can be a useful tool for theorists to succinctly and clearly present their hypotheses about the information contained in these representations. We then develop a methodology for using a series of linguistic probes to test the theories embodied in the act trees. In Study 1, we validate the method by testing a specific hypothesis (diagrammed by act trees) about how subjects are representing two classic moral dilemmas and finding that the data support the hypothesis...
May 21, 2018: Cognitive Science
https://www.readbyqxmd.com/read/29782181/effectiveness-of-an-osteopathic-abdominal-manual-intervention-in-pain-thresholds-lumbopelvic-mobility-and-posture-in-women-with-chronic-functional-constipation
#2
María José Martínez-Ochoa, Juan Carlos Fernández-Domínguez, Jose Miguel Morales-Asencio, Javier González-Iglesias, François Ricard, Ángel Oliva-Pascual-Vaca
OBJECTIVES: To assess the effect of an osteopathic abdominal manual intervention (AMI) on pressure pain thresholds (PPTs), mobility, hip flexibility, and posture in women with chronic functional constipation. DESIGN: Randomized, double-blind placebo-controlled trial. SETTING/LOCATION: Subjects were recruited for the study by referral from different gastroenterology outpatient clinics in the city of Madrid (Spain). SUBJECTS: Sixty-two patients suffering from chronic functional constipation according to the guidelines of the Congress of Rome III...
May 21, 2018: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/29781921/exercise-periodization-over-the-year-improves-metabolic-syndrome-and-medication-use
#3
Felix Morales-Palomo, Miguel Ramirez-Jimenez, Juan Fernando Ortega, Ricardo Mora-Rodriguez
PURPOSE: We aimed to determine if yearly repeated exercise training reduces metabolic syndrome (MetS) and the use of medicines to control MetS components. METHODS: Fifty five MetS individuals were randomized into a TRAIN group that underwent two yearly programs of 16-week of high intensity interval training (HIIT) or a non-exercising CONT group. We measured the evolution of all five MetS components, cardiorespiratory fitness (CRF; assessed by VO2PEAK) and medicine use, at baseline (0 months), mid (12 months) and end-point (24 months)...
May 2, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29780097/-required-support%C3%A3-an-examination-of-the-subjective-quality-of-life-and-related-factors-in-elderly-people-eith-a-high-functional-capacity-who-need-mild-care
#4
Katsuki Nakamura, Yoshiki Abe, Taiga Shibayama, Kikue Hidaka
AIM: We aimed to investigate subjective quality of life (QOL) and related factors in elderly people with a high functional capacity using daycare centers who require support and mild long-term care. METHODS: We collected data on the basic attributes, social background (hobbies, JST-Index of Competence), and subjective QOL (Revision PGC Morale Scale) through interviews with 238 people ≥65 years of age using daycare centers who required support and long-term care (level 1, 2)...
2018: Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
https://www.readbyqxmd.com/read/29779750/on-the-moral-import-of-the-arts-the-case-of-music
#5
Antoni Gomila, Julia F Christensen
There has been a controversy on the moral import of music and art in general. On the one hand, the moralist view contends that there is some sort of link between art and morality, even if the way to specify this link may be highly diverse. It comprises most of the classical views of art, from Schiller's view of the role of artistic education in moral development, to any view that declares a form of art as corrupt or degenerated, or enlightening. What it is assumed minimally in all of them is that the moral import of an artwork contributes to its aesthetic value...
2018: Progress in Brain Research
https://www.readbyqxmd.com/read/29777408/genetic-association-analysis-of-osteopontin-and-matrix-gla-protein-genes-polymorphisms-with-primary-knee-osteoarthritis-in-mexican-population
#6
Verónica Marusa Borgonio-Cuadra, Norma Celia González-Huerta, Emma Xochitl Rojas-Toledo, Eugenio Morales-Hernández, Nonanzit Pérez-Hernández, José Manuel Rodríguez-Pérez, Carlos Alfonso Tovilla-Zárate, Thelma Beatriz González-Castro, Yazmín Hernández-Díaz, María Lilia López-Narváez, Antonio Miranda-Duarte
Primary osteoarthritis (OA) is a complex entity in which several loci related to different molecular pathways or classes of molecules are associated with its development as demonstrated through genetic association studies. Genes involved in bone formation and mineralization, such as osteopontin (OPN) and Matrix Gla protein (MGP), could also be related with OA. The aim of this study was to evaluate the association between the genetic variants of OPN and MGP with primary knee osteoarthritis in a Mexican population...
May 18, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29773480/must-i-respond-if-my-health-is-at-risk
#7
Kenneth V Iserson
BACKGROUND: Widespread epidemics, pandemics, and other risk-prone disasters occur with disturbing regularity. When such events occur, how should, and will, clinicians respond? The moral backbone of medical professionals-a duty to put the needs of patients first-may be sorely tested. DISCUSSION: It is incumbent on health care professionals to ask what we must do and what we should do if a dangerous health care situation threatens both ourselves and our community...
May 14, 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29772697/structure-activity-relationships-based-on-3d-qsar-comfa-comsia-and-design-of-aryloxypropanol-amine-agonists-with-selectivity-for-the-human-%C3%AE-3-adrenergic-receptor-and-anti-obesity-and-anti-diabetic-profiles
#8
Marcos Lorca, Cesar Morales-Verdejo, David Vásquez-Velásquez, Juan Andrades-Lagos, Javier Campanini-Salinas, Jorge Soto-Delgado, Gonzalo Recabarren-Gajardo, Jaime Mella
The wide tissue distribution of the adrenergic β3 receptor makes it a potential target for the treatment of multiple pathologies such as diabetes, obesity, depression, overactive bladder (OAB), and cancer. Currently, there is only one drug on the market, mirabegron, approved for the treatment of OAB. In the present study, we have carried out an extensive structure-activity relationship analysis of a series of 41 aryloxypropanolamine compounds based on three-dimensional quantitative structure-activity relationship (3D-QSAR) techniques...
May 16, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29772347/location-dependent-correlation-between-tissue-structure-and-the-mechanical-behaviour-of-the-urinary-bladder
#9
Enrique Morales-Orcajo, Tobias Siebert, Markus Böl
The mechanical properties of the urinary bladder wall are important to understand its filling-voiding cycle in health and disease. However, much remains unknown about its mechanical properties, especially regarding regional heterogeneities and wall microstructure. The present study aimed to assess the regional differences in the mechanical properties and microstructure of the urinary bladder wall. Ninety (n=90) samples of porcine urinary bladder wall (ten samples from nine different locations) were mechanically and histologically analysed...
May 14, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29767648/antinociception-induced-by-copper-salt-revisited-interaction-with-ketamine-in-formalin-induced-intraplantar-and-orofacial-pain-in-mice
#10
Victoria Cazanga, Alejandro Hernandez, Bernardo Morales, Teresa Pelissier, Luis Constandil
AIMS: To evaluate in mice the antinociceptive effect of copper in spinal and trigeminal nociceptive pathways by using the intraplantar and orofacial formalin tests, respectively, and to examine whether this effect may interact synergistically with ketamine-induced antinociception. METHODS: Nociceptive behaviors (licking/biting of the formalin-injected limb and rubbing/scratching of the formalin-injected orofacial area) in male mice were evaluated during a 45-minute observation period post-formalin injection...
May 15, 2018: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/29764786/instability-in-patients-with-canvas-can-computerized-dynamic-posturography-help-in-diagnosis
#11
Alba Marina Milá de la Roca-Morales, Joan F Andreo-Marroig, Sofía Santos-Pérez, Andrés Soto-Varela
OBJECTIVE: To describe the pattern of dynamic posturography or its role in diagnosis in patients with cerebellar ataxia with neuropathy and vestibular arreflexia syndrome (CANVAS). MATERIALS AND METHODS: We present and describe posturographic data of four patients diagnosed with the CANVAS syndrome in a tertiary hospital. RESULTS: In all patients, the average balance score was diminished. Two patients presented a pattern of visual dependence...
April 2018: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/29764400/low-cost-hpv-testing-and-the-prevalence-of-cervical-infection-in-asymptomatic-populations-in-guatemala
#12
Hong Lou, Eduardo Gharzouzi, Sarita Polo Guerra, Joël Fokom Domgue, Julie Sawitzke, Guillermo Villagran, Lisa Garland, Joseph F Boland, Sarah Wagner, Héctor Rosas, Jami Troxler, Heidi McMillen, Bailey Kessing, Enrique Alvirez, Miriam Castillo, Hesler Morales, Victor Argueta, Andert Rosingh, Femke J H B van Aerde-van Nunen, Griselda Lopez, Herbert M Pinedo, Mark Schiffman, Michael Dean, Roberto Orozco
BACKGROUND: A low cost and accurate method for detecting high-risk (HR) human papillomavirus (HPV) is important to permit HPV testing for cervical cancer prevention. We used a commercially available HPV method (H13, Hybribio) which was documented to function accurately in a reduced volume of cervical specimen to determine the most prevalent HPV types and the distribution of HPV infections in over 1795 cancer-free women in Guatemala undergoing primary screening for cervical cancer by cytology...
May 15, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29755437/conditionally-rare-taxa-contribute-but-do-not-account-for-changes-in-soil-prokaryotic-community-structure
#13
Rachel Kaminsky, Sergio E Morales
The rare biosphere is predicted to aid in maintaining functional redundancy as well as contributing to community turnover across many environments. Recent developments have partially confirmed these hypotheses, while also giving new insights into dormancy and activity among rare communities. However, less attention has been paid to the rare biosphere in soils. This study provides insight into the rare biosphere's contribution to soil microbial diversity through the study of 781 soil samples representing 24 edaphically diverse sites...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29750232/in-vitro-evaluation-of-bond-strength-of-four-self-etching-cements
#14
Julio Chávez-Lozada, Carmen Urquía-Morales
Indirect restorations need to be attached with adhesive luting agents to prevent them from becoming dislodged and provide adequate marginal sealing. The aim of this study was to evaluate bond strength to dentin of self-etching resin cements. MATERIALS AND METHODS: 75 flat dentin surfaces were randomly distributed among 5 groups, according to cements used; Group 1: RelyxU100 (3M/ESPE), Group 2: Bis Cem (Bisco), Group 3: Max Cem (Kerr), Group 4: SeT PP (SDI) and Group 5: Relyx ARC (3M/ESPE), control...
December 2017: Acta Odontológica Latinoamericana: AOL
https://www.readbyqxmd.com/read/29745765/is-the-functional-threshold-power-ftp-a-valid-surrogate-of-the-lactate-threshold
#15
Pedro L Valenzuela, Javier S Morales, Carl Foster, Alejandro Lucia, Pedro de la Villa
PURPOSE: This study aimed to analyze the relationship between the Functional Threshold Power (FTP) and the Lactate Threshold (LT). METHODS: 20 male cyclists performed an incremental test in which the LT was determined. At least 48 h later, they performed a 20-minute time trial and 95% of the mean power output (P20) was defined as FTP. Participants were divided into recreational (Peak Power Output [PPO] < 4.5 W∙kg-1 , n=11) or trained cyclists (PPO > 4.5 W∙kg-1 , n=9) according to their fitness status...
May 10, 2018: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/29737938/how-can-men-convicted-of-violence-against-women-feel-moral-while-holding-sexist-and-violent-attitudes-a-homeostatic-moral-model-based-on-self-deception
#16
María L Vecina
A moral model is proposed to understand how men convicted of violence against the partner can feel moral in spite of their past violent behavior and their current violent and sexist attitudes. Because of its appeal to the role of self-deception and its relationship to psychological well-being, it was hypothesized that a rigid conception about what is right and wrong (moral absolutism) is associated with ambivalent outcomes that keep their psychological system in homeostasis. The relationships were specified a priori and tested using path analysis...
May 1, 2018: American Journal of Men's Health
https://www.readbyqxmd.com/read/29731732/the-cognition-of-severe-moral-failure-a-novel-approach-to-the-perception-of-evil
#17
Aner Govrin
I describe the perception of evil as a categorization judgment, based on a prototype, with extensive feedback loops and top-down influences. Based on the attachment approach to moral judgment (Govrin, 2014, 2018), I suggest that the perception of evil consists of four salient features: Extreme asymmetry between victim and perpetrator; a specific perceived attitude of the perpetrator toward the victim's vulnerability; the observer's inability to understand the perpetrator's perspective; and insuperable differences between the observer and perpetrator's judgment following the incident which shake the observer no less than the event itself...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29729330/paraoxonase-2-prevents-the-development-of-heart-failure
#18
Wei Li, David Kennedy, Zhili Shao, Xi Wang, Andre Klaassen Kamdar, Malory Weber, Kayla Mislick, Kathryn Kiefer, Rommel Morales, Brendan Agatisa-Boyle, Diana M Shih, Srinivasa T Reddy, Christine S Moravec, W H Wilson Tang
BACKGROUND: Mitochondrial oxidation is a major source of reactive oxygen species (ROS) and mitochondrial dysfunction plays a central role in development of heart failure (HF). Paraoxonase 2 deficient (PON2-def) mitochondria are impaired in function. In this study, we tested whether PON2-def aggravates HF progression. METHODS AND RESULTS: Using qPCR, immunoblotting and lactonase activity assay, we demonstrate that PON2 activity was significantly decreased in failing hearts despite increased PON2 expression...
May 2, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29729053/computed-tomography-is-a-feasible-method-for-quantifying-bone-density-in-macaca-mulatta
#19
Salvador A Solís-Chávez, Manuel A Castillo-Rivera, Marcela Arteaga-Silva, Alejandra Ibáñez-Contreras, Braulio Hernández-Godínez, Andrés Morón-Mendoza, Gamaliel Mendoza-Cuevas, Axayácatl Morales-Guadarrama, Emilio Sacristan-Rock
Osteopathologies are a result of advanced age and decreased bone density and represent a global health problem. It is therefore important to generate models for longitudinal studies of the pathophysiology in order to improve early diagnosis and develop preventive therapies. For this kind of research, the use of computed tomography (CT) to evaluate bone health offers advantages over other techniques since it provides more complete information. The aim of this prospective, pilot study was to obtain measurements of the left femur from a population in captivity of 32 rhesus monkeys (Macaca mulatta) in order to standardize the model for future research...
May 4, 2018: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/29725538/appendiceal-carcinoma-associated-with-microsatellite-instability
#20
Angélica Morales-Miranda, Ismael Domínguez Rosado, Carlos Chan Núñez, Fredy Chable Montero
Approximately 15% of colorectal cancer (CRC) cases exhibit microsatellite instability (MSI), which appears to be associated with unique biological behavior. The present study presents a case of appendiceal carcinoma associated with MSI that responded well to adjuvant chemotherapy. Clinical, pathological and immunohistochemical (IHC) characteristics have been described. The 60-year-old male patient had suffered from recurrent lower abdominal pain associated with abdominal distention for 6 months; then, following an acute attack, he was subjected to laparoscopic appendectomy...
May 2018: Molecular and Clinical Oncology
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