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https://www.readbyqxmd.com/read/28454292/dna-vaccine-encoding-human-papillomavirus-antigens-flanked-by-a-signal-peptide-and-a-kdel-sequence-induces-a-potent-therapeutic-antitumor-effect
#1
Jose J Perez-Trujillo, Rodolfo Garza-Morales, Jose A Barron-Cantu, Gabriel Figueroa-Parra, Aracely Garcia-Garcia, Humberto Rodriguez-Rocha, Jaime Garcia-Juarez, Gerardo E Muñoz-Maldonado, Odila Saucedo-Cardenas, Roberto Montes-De-Oca-Luna, Maria De Jesus Loera-Arias
Cellular immune responses play a critical role in the eradication of intracellular infections and malignant cells through the recognition and subsequent removal of the infection or malignant cells. Effective antigen presentation is crucial for stimulating the immune system against malignant cells. Calreticulin (CRT) has been used to improve antigen presentation. However, CRT overexpression has been previously associated with the development of pancreatic and breast cancer. The import and retention signals of CRT in the endoplasmic reticulum (ER) can be used to overcome CRT overexpression...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454059/outcome-focused-judgements-of-moral-dilemmas-in-schizophrenia
#2
Jonathan McGuire, Martin Brüne, Robyn Langdon
Previous research on moral judgement in healthy adults suggests a complex interplay of automatic, emotional and deliberative processing. We aimed to advance understanding of these processes by examining moral judgement in individuals with schizophrenia, a population characterised by social-cognitive deficits and interpersonal difficulties. Forty-five patients with schizophrenia and 27 healthy controls judged high-conflict moral dilemmas in response to 3rd-person (i.e. "Is it morally okay to [perform X]?") and 1st-person (i...
April 25, 2017: Consciousness and Cognition
https://www.readbyqxmd.com/read/28453300/psychiatry-sex-and-science-the-making-of-adolescent-motherhood-in-southern-brazil
#3
Dominique P Béhague
Research linking teen motherhood to psychoneurodevelopmental causes and pathologies has proliferated in the past two decades. In Brazil, a psychodevelopmental project of teen motherhood has gained traction despite many experts' long-standing commitment to psychodynamic psychiatry and social epidemiology, generating epistemic tension rather than substitution. Drawing on historical ethnography conducted in Southern Brazil, I explore how this project materialized through the co-production of epistemic struggles, remedial interventions, and ontological politics...
April 28, 2017: Medical Anthropology
https://www.readbyqxmd.com/read/28449327/skeletal-muscle-il-15-il-15r%C3%AE-and-myofibrillar-protein-synthesis-after-resistance-exercise
#4
Alberto Pérez-López, James McKendry, Marcos Martin-Rincon, David Morales-Alamo, Bárbara Pérez-Köhler, David Valadés, Julia Buján, Jose A L Calbet, Leigh Breen
In vitro and in vivo studies described the myokine IL-15 and its receptor IL-15Rα as anabolic/anti-atrophy agents, however the protein expression of IL-15Rα has not been measured in human skeletal muscle and data regarding IL-15 expression remain inconclusive. The purpose of the study was to determine serum and skeletal muscle IL-15 and IL-15Rα responses to resistance exercise session and to analyse their association with myofibrillar protein synthesis (MPS). Fourteen participants performed a bilateral leg resistance exercise composed of 4 sets of leg press and 4 sets of knee extension at 75% 1RM to task failure...
April 27, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28448506/the-dynamics-of-behavior-in-modified-dictator-games
#5
Jeannette Brosig-Koch, Thomas Riechmann, Joachim Weimann
We investigate the dynamics of individual pro-social behavior over time. The dynamics are tested by running the same experiment with the same subjects at several points in time. To exclude learning and reputation building, we employ non-strategic decision tasks and a sequential prisoners-dilemma as a control treatment. In the first wave, pro-social concerns explain a high share of individual decisions. Pro-social decisions decrease over time, however. In the final wave, most decisions can be accounted for by assuming pure selfishness...
2017: PloS One
https://www.readbyqxmd.com/read/28448208/explanations-for-not-receiving-the-seasonal-influenza-vaccine-an-ontario-canada-based-survey
#6
Samantha B Meyer, Rebecca Lum
Despite evidence of the importance of the seasonal influenza vaccine for both individual and population health, only a third of the Ontario population received the vaccine in 2013/2014. The objective of this study was to identify why Ontarians are not getting the seasonal influenza vaccine. Written responses to the question "Why didn't you get the seasonal flu vaccine in the last flu season?" were deductively analyzed using the Conceptual Model of Vaccine Hesitancy. Inductive coding was also conducted to identify explanations that fall outside of the present model and may be unique to the seasonal influenza vaccine...
April 27, 2017: Journal of Health Communication
https://www.readbyqxmd.com/read/28448188/effects-of-indomethacin-on-prostanoid-synthesis-and-vasomotor-responsiveness-in-endothelium-denuded-abdominal-and-thoracic-aortas-of-wistar-rats
#7
Ruth M López, Janette E López, Jorge S López, María C Castillo, Gustavo Guevara, José A Morales, Oscar A López, Jair Lozano, Enrique F Castillo
In endothelium-denuded abdominal (but not thoracic) aortas of rats, the nonselective cyclooxygenase (COX) inhibitor, indomethacin, suppressed contractions evoked by α-adrenergic agonists hypothetically mediated by prostanoids. We aimed to identify these non-endothelial-derived contractile prostanoids released by α-adrenergic receptors activation. Endothelium-denuded abdominal and thoracic aortas of Wistar rats were used for biochemical and functional analyses. Western blot analysis showed that COX-1 and COX-2 protein levels were respectively equivalent in endothelium-denuded abdominal and thoracic aortas...
2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28447991/isolation-and-characterization-of-mesenchymal-stromal-cells-from-human-umbilical-cord-and-fetal-placenta
#8
Naimisha Beeravolu, Christina McKee, Ali Alamri, Sasha Mikhael, Christina Brown, Mick Perez-Cruet, G Rasul Chaudhry
The human umbilical cord (UC) and placenta are non-invasive, primitive and abundant sources of mesenchymal stromal cells (MSCs) that have increasingly gained attention because they do not pose any ethical or moral concerns. Current methods to isolate MSCs from UC yield low amounts of cells with variable proliferation potentials. Since UC is an anatomically-complex organ, differences in MSC properties may be due to the differences in the anatomical regions of their isolation. In this study, we first dissected the cord/placenta samples into three discrete anatomical regions: UC, cord-placenta junction (CPJ), and fetal placenta (FP)...
April 3, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28447910/chemical-and-biological-assessment-of-metal-organic-frameworks-mofs-in-pulmonary-cells-and-in-an-acute-in-vivo-model-relevance-to-pulmonary-arterial-hypertension-therapy
#9
Nura Adam Mohamed, Robert P Davies, Paul D Lickliss, Blerina Ahmetaj-Shala, Daniel M Reed, Hime H Gashaw, Hira Saleem, Gemma R Freeman, Peter M George, John Wort, Daniel Morales-Cano, Bianca Barreira, Teresa D Tetley, Adrian H Chester, Magdi Yacoub, Nicholas S Kirkby, Laura Moreno, Jane A Mitchell
No abstract text is available yet for this article.
January 1, 2017: Pulmonary Circulation
https://www.readbyqxmd.com/read/28446891/moral-attitudes-predict-cheating-and-gamesmanship-behaviors-among-competitive-tennis-players
#10
Fabio Lucidi, Arnaldo Zelli, Luca Mallia, Giampaolo Nicolais, Lambros Lazuras, Martin S Hagger
Background: The present study tested Lee et al.'s (2008) model of moral attitudes and cheating behavior in sports in an Italian sample of young tennis players and extended it to predict behavior in actual match play. In the first phase of the study we proposed that moral, competence and status values would predict prosocial and antisocial moral attitudes directly, and indirectly through athletes' goal orientations. In the second phase, we hypothesized that moral attitudes would directly predict actual cheating behavior observed during match play...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28446736/violating-organizational-and-social-norms-in-the-workplace-a-correlational-study-in-the-nursing-context
#11
Francesco Zaghini, Valentina Biagioli, Rosario Caruso, Sondra Badolamenti, Roberta Fida, Alessandro Sili
OBJECTIVES: The aim of this study was to examine, in a sample of nurses, the relationships between the organizational context variables (i.e., workload, interpersonal conflicts, organizational constraints), the burnout, the moral disengagement, and the counterproductive work behaviors (CWB), within their clinical work settings. METHODS: A descriptive, correlational study was conducted in a sample of 347 nurses working in different clinical settings in a big university hospital in Central Italy...
April 21, 2017: La Medicina del Lavoro
https://www.readbyqxmd.com/read/28446528/quitting-patient-care-and-career-break-intentions-among-general-practitioners-in-south-west-england-findings-of-a-census-survey-of-general-practitioners
#12
Emily Fletcher, Gary A Abel, Rob Anderson, Suzanne H Richards, Chris Salisbury, Sarah Gerard Dean, Anna Sansom, Fiona C Warren, John L Campbell
OBJECTIVE: Given recent concerns regarding general practitioner (GP) workforce capacity, we aimed to describe GPs' career intentions, especially those which might impact on GP workforce availability over the next 5 years. DESIGN: Census survey, conducted between April and June 2016 using postal and online responses , of all GPs on the National Health Service performers list and eligible to practise in primary care. Two reminders were used as necessary. SETTING: South West England (population 3...
April 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28446105/evaluating-methods-of-correcting-for-multiple-comparisons-implemented-in-spm12-in-social-neuroscience-fmri-studies-an-example-from-moral-psychology
#13
Hyemin Han, Andrea L Glenn
In fMRI research, the goal of correcting for multiple comparisons is to identify areas of activity that reflect true effects, and thus would be expected to replicate in future studies. Finding an appropriate balance between trying to minimize false positives (Type I error) while not being too stringent and omitting true effects (Type II error) can be challenging. Furthermore, the advantages and disadvantages of these types of errors may differ for different areas of study. In many areas of social neuroscience that involve complex processes and considerable individual differences, such as the study of moral judgment, effects are typically smaller and statistical power weaker, leading to the suggestion that less stringent corrections that allow for more sensitivity may be beneficial, but also result in more false positives...
April 27, 2017: Social Neuroscience
https://www.readbyqxmd.com/read/28445290/efficacy-of-quadriceps-vastus-medialis-dry-needling-in-a-rehabilitation-protocol-after-surgical-reconstruction-of-complete-anterior-cruciate-ligament-rupture
#14
Jorge Velázquez-Saornil, Beatriz Ruíz-Ruíz, David Rodríguez-Sanz, Carlos Romero-Morales, Daniel López-López, Cesar Calvo-Lobo
BACKGROUND: Several new rehabilitation modalities have been proposed after anterior cruciate ligament (ACL) reconstruction. Among these, trigger point dry needling (TrP-DN) might be useful in the treatment of myofascial pain syndrome associated with ACL reconstruction to reduce pain intensity, increase knee flexion range and modify the mechanical properties of the quadriceps muscle during late-stage rehabilitation. To date, this is the first randomized clinical trial to support the use of TrP-DN in the early rehabilitation process after ACL reconstruction...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28444972/production-and-application-of-a-thermostable-lipase-from-serratia-marcescens-in-detergent-formulation-and-biodiesel-production
#15
Edgar Edurman García-Silvera, Fernando Martínez-Morales, Brandt Bertrand, Daniel Morales-Guzman, Nashbly Sarela Rosas-Galván, Renato León-Rodríguez, María Del Refugio Trejo-Hernández
In this study, extracellular lipase was produced by Serratia marcescens wild type and three mutant strains. The maximum lipase activity (80 U/mL) was obtained with the SMRG4 mutant strain using soybean oil. Using a 2(2) factorial design the lipase production increased 1.55-fold (124 U/mL) with 4% and 0.05 % soybean oil and Triton X-100, respectively. The optimum conditions for maximum lipase activity were 50°C and pH 8. However, the enzyme was active in a broad range of pH (6-10) and temperatures (5-55°C)...
April 26, 2017: Biotechnology and Applied Biochemistry
https://www.readbyqxmd.com/read/28444821/has-the-autonomy-pendulum-swung-too-far
#16
Paul Walker
BACKGROUND: This paper aims to contribute to the discussion about patient-centred care in surgery. It is contended here that the paradigm shift towards patient-centred decision-making in health care does not mean that patient values alone (or those of their proxies) should, uncritically, be the lead decision makers in determining surgical care. METHODS: In support of that contention, three clarifications to our conception of autonomy will be offered. RESULTS: First, autonomy may not be best positioned as the lead principle guiding healthcare decision-making...
April 25, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28444724/the-morality-of-good-end-of-life-care-in-critical-care
#17
EDITORIAL
Natalie Pattison
No abstract text is available yet for this article.
May 2017: Nursing in Critical Care
https://www.readbyqxmd.com/read/28444599/study-of-enzymatic-saccharification-of-agave-leaves-biomass-to-yield-fermentable-sugars
#18
Miguel A Medina-Morales, Oscar Soto-Cruz, Juan C Contreras-Esquivel, Raúl Rodríguez-Herrera, Heliodoro De la Garza-Toledo, Cristóbal N Aguilar
Agave is a good source of polysaccharides for the production of fermentable sugars as sustainable bioenergy feedstock solutions for semi-arid and arid lands. This plant grows in arid areas, which correspond to a large territory in northern Mexico. Having lignocellulose as the polysaccharide of interest, the information for the enzymatic saccharification of this kind of material is limited. Agave cell walls have a unique recalcitrant nature, but having a high cellulose content, makes this plant material an interesting research subject...
May 2017: 3 Biotech
https://www.readbyqxmd.com/read/28444131/fulvestrant-plus-lhrh-analogs-in-male-with-synchronous-breast-and-prostate-cancer
#19
C Martinez, L A Fernández-Morales, H Oliveres, M Marín, P Ribera, J C Pardo, E Dalmau, M A Segui
No abstract text is available yet for this article.
April 24, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28443785/acute-and-long-term-impact-of-high-protein-diets-on-endocrine-and-metabolic-function-body-composition-and-exercise-induced-adaptations
#20
Flor E Morales, Grant M Tinsley, Paul M Gordon
BACKGROUND: High-protein diets have been shown to improve body composition through alterations in satiety, muscle protein synthesis, and the thermic effect of food. AIM: Given these findings, the purpose of this review is to discuss the integration of the specific hormonal and metabolic effects of high-protein diets following both acute and long-term usage, especially with regard to body composition. METHODS: Full-text articles were obtained through PubMed by using the terms "high-protein diet and body composition," "high-protein diet and exercise," "high-protein diet risk," "high-protein diet side effects," "protein quality PDCAAS," "RDA for protein," and "daily protein recommendation...
April 26, 2017: Journal of the American College of Nutrition
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