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https://www.readbyqxmd.com/read/27933533/systems-genetics-as-a-tool-to-identify-master-genetic-regulators-in-complex-disease
#1
Aida Moreno-Moral, Francesco Pesce, Jacques Behmoaras, Enrico Petretto
Systems genetics stems from systems biology and similarly employs integrative modeling approaches to describe the perturbations and phenotypic effects observed in a complex system. However, in the case of systems genetics the main source of perturbation is naturally occurring genetic variation, which can be analyzed at the systems-level to explain the observed variation in phenotypic traits. In contrast with conventional single-variant association approaches, the success of systems genetics has been in the identification of gene networks and molecular pathways that underlie complex disease...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27933026/fitness-costs-predict-emotional-moral-and-attitudinal-inbreeding-aversion
#2
Florence Lespiau, Gwenaël Kaminski
In terms of sexual intercourse, the very last people we think about are our kin. Imagining inbreeding intercourse, whether it involves our closest kin or not, induces aversion in most people who invoke inbreeding depression problems or cultural considerations. Research has focused on the disgust felt when facing inbreeding intercourse between close kin but little is known about other responses. In this study, we considered the influence of fitness costs on aversive reactions by including disgust and emotional reaction as well as moral judgment and attitudes toward inbreeding: higher costs should induce a stronger aversive reaction...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27933017/why-acting-environmentally-friendly-feels-good-exploring-the-role-of-self-image
#3
Leonie A Venhoeven, Jan Willem Bolderdijk, Linda Steg
Recent research suggests that engagement in environmentally-friendly behavior can feel good. Current explanations for such a link do not focus on the nature of environmentally-friendly behavior itself, but rather propose well-being is more or less a side-benefit; behaviors that benefit environmental quality (e.g., spending one's money on people rather than products) also tend to make us feel good. We propose that the moral nature of environmentally-friendly behavior itself may elicit positive emotions as well, because engaging in this behavior can signal one is an environmentally-friendly and thus a good person...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27932949/muscle-type-nicotinic-receptor-modulation-by-2-6-dimethylaniline-a-molecule-resembling-the-hydrophobic-moiety-of-lidocaine
#4
Armando Alberola-Die, Gregorio Fernández-Ballester, José M González-Ros, Isabel Ivorra, Andrés Morales
To identify the molecular determinants responsible for lidocaine blockade of muscle-type nAChRs, we have studied the effects on this receptor of 2,6-dimethylaniline (DMA), which resembles lidocaine's hydrophobic moiety. Torpedo marmorata nAChRs were microtransplanted to Xenopus oocytes and currents elicited by ACh (IACh), either alone or co-applied with DMA, were recorded. DMA reversibly blocked IACh and, similarly to lidocaine, exerted a closed-channel blockade, as evidenced by the enhancement of IACh blockade when DMA was pre-applied before its co-application with ACh, and hastened IACh decay...
2016: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/27932946/increased-brain-neurotensin-and-ntsr2-lead-to-weak-nociception-in-ntsr3-sortilin-knockout-mice
#5
Christelle Devader, Sébastien Moreno, Morgane Roulot, Emmanuel Deval, Thomas Dix, Carlos R Morales, Jean Mazella
The neuropeptide neurotensin (NT) elicits numerous pharmacological effects through three different receptors (NTSR1, NTSR2, and NTSR3 also called sortilin). Pharmacological approaches and generation of NTSR1 and NTSR2-deficient mice allowed to determine the NT-induced antipsychotic like behavior, the inhibitory of weak fear memory and the nociceptive signaling in a rat formalin tonic pain model to NTSR1. Conversely, the effects of NT on thermal and tonic nociceptions were mediated by NTSR2. However, the role of NTSR3/sortilin on the neurotensinergic system was not investigated...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27932677/suite-of-clinically-relevant-functional-assays-to-address-therapeutic-efficacy-and-disease-mechanism-in-the-dystrophic-mdx-mouse
#6
Yafeng Song, Shira Tziporah Rosenblum, Leon Morales, Mihail Petrov, Christopher Greer, Samantha Globerman, Hansell H Stedman
Duchenne muscular dystrophy (DMD) is a progressive primary myodegenerative disease caused by a genetic deficiency of the 427 KD cytoskeletal protein dystrophin. Despite its single-gene etiology, DMD's complex pathogenesis remains poorly understood, complicating the extrapolation from results of preclinical studies in genetic homologues to the design of informative clinical trials. Here we describe novel phenotypic assays which when applied to the mdx mouse resemble recently used primary endpoints for DMD clinical trials...
December 8, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27932633/agents-of-reconciliation-agency-affirmation-promotes-constructive-tendencies-following-transgressions-in-low-commitment-relationships
#7
Ilanit SimanTov-Nachlieli, Nurit Shnabel, Anael Mori-Hoffman
Conflicting parties experience threats to both their agency and morality, but the experience of agency-threat exerts more influence on their behavior, leading to relationship-destructive tendencies. Whereas high-commitment relationships facilitate constructive tendencies despite the conflict, we theorized that in low-commitment relationships, affirming the adversary's agency is a prerequisite for facilitating more constructive tendencies. Focusing on sibling conflicts, Study 1 found that when commitment was low (rather than high), agency-affirmation increased participants' constructive tendencies toward their brother/sister compared with a control/no-affirmation condition...
December 8, 2016: Personality & Social Psychology Bulletin
https://www.readbyqxmd.com/read/27932381/improving-the-efficiency-of-care-for-pediatric-patients-hospitalized-with-asthma
#8
Kathleen W Bartlett, Victoria M Parente, Vanessa Morales, Jillian Hauser, Heather S McLean
BACKGROUND: Asthma exacerbations are a leading cause of hospitalization among children. Despite the existence of national pediatric asthma guidelines, significant variation in care persists. At Duke Children's Hospital, we determined that our average length of stay (ALOS) and cost for pediatric asthma admissions exceeded that of our peers. Our aim was to reduce the ALOS of pediatric patients hospitalized with asthma from 2.9 days to 2.6 days within 12 months by implementing an asthma pathway within our new electronic health record...
December 8, 2016: Hospital Pediatrics
https://www.readbyqxmd.com/read/27932106/assessment-of-kidney-graft-function-evolution-measured-by-creatinine-and-cystatin-c
#9
M A Ramos-Barron, I Hernandez Bejarano, E Rodrigo, E Cruz Iglesias, A Benito Hernandez, C Agueros Blanco, A I Morales Martin, M Prieto Vicente, F Lopez Hernandez, M Arias, C Gomez-Alamillo
INTRODUCTION: The 2013 Kidney Disease Outcomes Quality Initiative Clinical Practice Guideline suggests measuring cystatin C (sCys) in adults with glomerular filtration rate (GFR) based on creatinine (sCr) between 45 and 59 mL/min/1.73 m(2) if confirmation of chronic kidney disease (CKD) is required. There is not enough evidence to recommend the use of sCys or sCr to estimate GFR in kidney transplant recipients. OBJECTIVES: Our aims were to describe the evolution of sCr, sCys, and GFR in a group of kidney transplant patients and to determine their association with some markers of morbidity at 1 year...
November 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27932096/study-of-%C3%AE-2-glycoprotein-i-polymorphisms-in-patients-with-chronic-renal-failure-as-a-predisposing-factor-for-the-development-of-anti-%C3%AE-2-glycoprotein-i-auto-antibodies
#10
M Serrano, O Cabrera-Marante, J A Martínez-Flores, P Morales, D Pérez, S Mora, F García, E González, E Paz-Artal, J M Morales, A Serrano
BACKGROUND: Immunoglobulin (Ig)A anti-β2-glycoprotein I (aB2GP1) antibodies are associated with thrombotic events, cardiovascular morbidity, and death in dialysis patients. About 30% of patients with chronic renal disease are positive for IgA aB2GP1; however, the origin of these antibodies is unknown. It has been speculated that dialysis membranes, age, or etiology of renal base disease are possible precipitating factors, although these factors do not appear to be the source of antibodies...
November 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27932009/mobile-marketing-to-children-a-content-analysis-of-food-and-beverage-company-apps
#11
L B Hurwitz, E D Morales, H Montague, A R Lauricella, E Wartella
No abstract text is available yet for this article.
December 2016: Public Health
https://www.readbyqxmd.com/read/27931953/basal-cell-carcinoma-in-young-adults
#12
J Garcias-Ladaria, F J Morales-Morato, M Cuadrado Rosón, V Rocamora
No abstract text is available yet for this article.
December 5, 2016: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/27931770/fractional-flow-reserve-assessment-with-adenosine-be-aware-of-the-qt-interval
#13
David Martí, María José Morales, Salvador Álvarez, Jorge Palazuelos, Ignacio Rada
No abstract text is available yet for this article.
December 5, 2016: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/27931155/prenatal-paradox-an-integrative-review-of-women-s-experiences-with-prenatal-screening-for-fetal-aneuploidy-and-neural-tube-defects
#14
Tamra L Shea
Background Prenatal screening for fetal aneuploidy and neural tube defects has been incorporated in prenatal care through much of the industrialized world. As prenatal screening evolves technologically and becomes increasingly utilized worldwide, a summary and evaluation of the available evidence on women's experiences with prenatal screening is warranted. Aims To conduct an integrative review to evaluate and synthesize available literature to enhance understanding of women's experiences with prenatal screening for fetal aneuploidy and neural tube defects...
December 9, 2016: Contemporary Nurse
https://www.readbyqxmd.com/read/27930369/measuring-moral-distress-among-critical-care-clinicians-validation-and-psychometric-properties-of-the-italian-moral-distress-scale-revised
#15
Giulia Lamiani, Ilaria Setti, Luca Barlascini, Elena Vegni, Piergiorgio Argentero
OBJECTIVES: Moral distress is a common experience among critical care professionals, leading to frustration, withdrawal from patient care, and job abandonment. Most of the studies on moral distress have used the Moral Distress Scale or its revised version (Moral Distress Scale-Revised). However, these scales have never been validated through factor analysis. This article aims to explore the factorial structure of the Moral Distress Scale-Revised and develop a valid and reliable scale through factor analysis...
December 7, 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27928981/characterization-of-cyclin-dependent-kinases-and-cdc2-cdc28-kinase-subunits-in-trichomonas-vaginalis
#16
Erick Amador, Karla López-Pacheco, Nataly Morales, Roberto Coria, Imelda López-Villaseñor
Cyclin-dependent kinases (CDKs) have important roles in regulating key checkpoints between stages of the cell cycle. Their activity is tightly regulated through a variety of mechanisms, including through binding with cyclin proteins and the Cdc2/Cdc28 kinase subunit (CKS), and their phosphorylation at specific amino acids. Studies of the components involved in cell cycle control in parasitic protozoa are limited. Trichomonas vaginalis is the causative agent of trichomoniasis in humans and is therefore important in public health; however, some of the basic biological processes used by this organism have not been defined...
December 8, 2016: Parasitology
https://www.readbyqxmd.com/read/27927070/evaluation-of-antioxidant-and-hepatoprotective-effects-of-white-cabbage-essential-oil
#17
Javier Morales-López, Mónica Centeno-Álvarez, Antonio Nieto-Camacho, Mercedes G López, Elizabeth Pérez-Hernández, Nury Pérez-Hernández, Eduardo Fernández-Martínez
CONTEXT: There have been no reports of the extraction of essential oil (EO) from white cabbage [Brassica oleracea L. var. capitata (L.) Alef. f. alba DC. (Brassicaceae)] (Bocfal) or its chemical composition, antioxidant activity, or hepatoprotective effects. OBJECTIVE: To extract Bocfal EO, to identify and quantify its chemical components, to assess their antioxidant capacity, and to evaluate the hepatoprotective properties of Bocfal EO. MATERIALS AND METHODS: Bocfal EO was obtained using hydrodistillation (200 mm Hg/58 °C)...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27927034/addressing-challenges-for-youths-with-mobility-devices-in-winter-conditions
#18
Ernesto Morales, Sally Lindsay, Geoffrey Edwards, Lori Howell, Claude Vincent, Nicole Yantzi, Véronique Gauthier
PURPOSE: Winter-related research about the experience of navigating in the urban context has mostly focused on the elderly population with physical disabilities. The aim of this project was to explore potential design solutions to enhance young people's mobility devices and the built environment to improve accessibility and participation in winter. METHODS: A multi-method qualitative design process included the following steps: (1) in-depth interviews; (2) photo elicitation; (3) individual co-design sessions; and (4) group co-design sessions (i...
December 7, 2016: Disability and Rehabilitation
https://www.readbyqxmd.com/read/27926923/deforestation-impacts-on-bat-functional-diversity-in-tropical-landscapes
#19
Rodrigo García-Morales, Claudia E Moreno, Ernesto I Badano, Iriana Zuria, Jorge Galindo-González, Alberto E Rojas-Martínez, Eva S Ávila-Gómez
Functional diversity is the variability in the functional roles carried out by species within ecosystems. Changes in the environment can affect this component of biodiversity and can, in turn, affect different processes, including some ecosystem services. This study aimed to determine the effect of forest loss on species richness, abundance and functional diversity of Neotropical bats. To this end, we identified six landscapes with increasing loss of forest cover in the Huasteca region of the state of Hidalgo, Mexico...
2016: PloS One
https://www.readbyqxmd.com/read/27926437/involvement-of-opioid-signaling-in-food-preference-and-motivation-studies-in-laboratory-animals
#20
I Morales, L Font, P J Currie, R Pastor
Motivation is a complex neurobiological process that initiates, directs, and maintains goal-oriented behavior. Although distinct components of motivated behavior are difficult to investigate, appetitive and consummatory phases of motivation are experimentally separable. Different neurotransmitter systems, particularly the mesolimbic dopaminergic system, have been associated with food motivation. Over the last two decades, however, research focusing on the role of opioid signaling has been particularly growing in this area...
2016: Progress in Brain Research
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