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https://www.readbyqxmd.com/read/27922905/scale-up-of-an-human-papillomavirus-testing-implementation-program-in-el-salvador
#1
Miriam Cremer, Mauricio Maza, Karla Alfaro, Mario Morales Velado, Juan Felix, Philip E Castle, Jane Kim, Julia C Gage
OBJECTIVE: The Cervical Cancer Prevention in El Salvador is a demonstration project to introduce a lower-cost human papillomavirus (HPV)-DNA test into a public sector project. Started in October 2012, The Cervical Cancer Prevention in El Salvador consists of 3 phases and will ultimately screen 30,000 women. Results of phase 2 of the project are presented. The objective of this project was to compare colposcopy and noncolposcopy-based management for HPV-positive women. MATERIAL AND METHODS: In phase 2, a total of 8,050 women, aged 30 to 49 years, were screened; 6,761 provided both self- and provider-collected specimens and 1,289 provided only provider-testing specimens...
December 6, 2016: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/27914296/gender-differences-in-primary-home-caregivers-of-older-relatives-in-a-mediterranean-environment-a-cross-sectional-study
#2
Rafael Del-Pino-Casado, María Del Mar Pastor-Bravo, Pedro A Palomino-Moral, Antonio Frías-Osuna
A cross-sectional study was developed in Spain to analyse gender differences in intensity of care, care recipient needs and subjective burden, as well as the moderating effects of kinship on the relationship between gender and subjective burden. A probabilistic sample of 200 primary caregivers (100 male and 100 female) of older relatives was interviewed by expert nurses. Socio-demographic data and several scales regarding objective and subjective burden were used to collect data. Descriptive statistics, Student's t-test, ANOVA and multiple linear regression were used to analyse the data...
November 21, 2016: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/27907891/analysis-of-translation-using-polysome-profiling
#3
Héloïse Chassé, Sandrine Boulben, Vlad Costache, Patrick Cormier, Julia Morales
During the past decade, there has been growing interest in the role of translational regulation of gene expression in many organisms. Polysome profiling has been developed to infer the translational status of a specific mRNA species or to analyze the translatome, i.e. the subset of mRNAs actively translated in a cell. Polysome profiling is especially suitable for emergent model organisms for which genomic data are limited. In this paper, we describe an optimized protocol for the purification of sea urchin polysomes and highlight the critical steps involved in polysome purification...
October 7, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27905829/post-traumatic-stress-disorder-dimensions-and-asthma-morbidity-in-world-trade-center-rescue-and-recovery-workers
#4
Irina Mindlis, Esperanza Morales-Raveendran, Emily Goodman, Kevin Xu, Clara Vila-Castelar, Kristine Keller, Ginger Crawford, Shynah James, Craig Katz, Laura E Crowley, Rafael E de la Hoz, Steven Markowitz, Juan P Wisnivesky
Objective Using data from a cohort of World Trade Center (WTC) rescue and recovery workers with asthma, we assessed whether meeting criteria for post-traumatic stress disorder (PTSD), sub- PTSD and for specific PTSD symptom dimensions are associated with increased asthma morbidity. Methods Participants underwent a Structured Clinical Interview for Diagnostic and Statistical Manual to assess presence of PTSD following DSM-IV criteria during in-person interviews between December 2013 and April 2015. We defined sub-threshold PTSD as meeting criteria for two of three symptom dimensions: re-experiencing, avoidance, or hyper-arousal...
December 1, 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/27905097/novel-biomarkers-in-primary-breast-core-biopsies-to-predict-poor-response-to-neoadjuvant-chemotherapy-and-appearance-of-metastases
#5
Anna Novell, Serafin Morales, Joan Valls, Maria José Panadés, Antonieta Salud, Edelmiro Iglesias, Felip Vilardell, Xavier Matias-Guiu, Antonio Llombart-Cussac
Drug resistance has been one of the major obstacles limiting the success of cancer chemotherapy. In two thirds of breast cancer patients, large (>1cm) residual tumors are present after neoadjuvant chemotherapy (NCT). The residual tumor and involved nodes have been indicators of relapse and survival very important in breast cancer. The goal of this preliminary study was to assess the predictive significance of a panel of molecular biomarkers, related with the response to treatment or drug resistance to NCT, as determined on the diagnostic tumor...
December 1, 2016: Histology and Histopathology
https://www.readbyqxmd.com/read/27899670/the-new-nhgri-ebi-catalog-of-published-genome-wide-association-studies-gwas-catalog
#6
Jacqueline MacArthur, Emily Bowler, Maria Cerezo, Laurent Gil, Peggy Hall, Emma Hastings, Heather Junkins, Aoife McMahon, Annalisa Milano, Joannella Morales, Zoe May Pendlington, Danielle Welter, Tony Burdett, Lucia Hindorff, Paul Flicek, Fiona Cunningham, Helen Parkinson
The NHGRI-EBI GWAS Catalog has provided data from published genome-wide association studies since 2008. In 2015, the database was redesigned and relocated to EMBL-EBI. The new infrastructure includes a new graphical user interface (www.ebi.ac.uk/gwas/), ontology supported search functionality and an improved curation interface. These developments have improved the data release frequency by increasing automation of curation and providing scaling improvements. The range of available Catalog data has also been extended with structured ancestry and recruitment information added for all studies...
November 29, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27889589/higher-morale-is-associated-with-lower-risk-of-depressive-disorders-five-years-later-among-very-old-people
#7
Johan Niklasson, Marina Näsman, Fredrica Nyqvist, Mia Conradsson, Birgitta Olofsson, Hugo Lövheim, Yngve Gustafson
The aim of this study was to investigate whether higher morale, i.e. future-oriented optimism, at baseline was associated with lower risk of depressive disorders five years later among very old people.Methods The Umeå85+/GErontological Regional Database, a population-based study with a longitudinal design, recruited participants in Sweden and Finland aged 85, 90 and ≥95 years. The sample in the present study included 647 individuals (89.1±4.4 years (Mean±SD), range 85-103). After five years, 216 were alive and agreed to a follow-up (92...
November 17, 2016: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/27887610/integral-strategy-to-supportive-care-in-breast-cancer-survivors-through-occupational-therapy-and-a-m-health-system-design-of-a-randomized-clinical-trial
#8
Mario Lozano-Lozano, Lydia Martín-Martín, Noelia Galiano-Castillo, Francisco Álvarez-Salvago, Irene Cantarero-Villanueva, Carolina Fernández-Lao, Carmen Sánchez-Salado, Manuel Arroyo-Morales
BACKGROUND: Technological support using e-health mobile applications (m-health) is a promising strategy to improve the adherence to healthy lifestyles in breast cancer survivors (excess in energy intake or low physical activity are determinants of the risk of recurrence, second cancers and cancer mortality). Moreover, cancer rehabilitation programs supervised by health professionals are needed due to the inherent characteristics of these breast cancer patients. Our main objective is to compare the clinical efficacy of a m-health lifestyle intervention system alone versus an integral strategy to improve Quality of Life in breast cancer survivors...
November 25, 2016: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/27884400/stephen-jay-gould-and-the-value-neutrality-of-science-during-the-late-cold-war
#9
Myrna Sheldon
Stephen Jay Gould was a paleontologist and scientific celebrity at the close of the twentieth century, most famous for his popular writings on evolution and his role in the American creationist controversies of that era. In the early 1980s, Gould was drawn into the "nuclear winter" episode through his friendship with Carl Sagan, an astronomer and popular science celebrity. Sagan helped develop the theory of nuclear winter and subsequently used the theory as evidence to petition the United States government to scale back its nuclear armament...
November 21, 2016: Endeavour
https://www.readbyqxmd.com/read/27869906/-emotional-intelligence-index-a-tool-for-the-routine-assessment-of-mental-health-promotion-programs-in-schools
#10
Franco Veltro, Valentina Ialenti, Manuel Alejandro Morales García, Antonella Gigantesco
AIM: After critical examination of several aspects relating to the evaluation of some dimensions of emotional intelligence through self-assessment tools, is described the procedure of construction and validation of an Index for its measurement, conceived only for the routine assessment of health promotion programs mental in schools that include among their objectives the improvement of emotional intelligence specifically "outcome-oriented". METHODS: On the basis of the two most common international tools, are listed 27 items plus 6 of control, illustrated two Focus Group (FG) of students (face validity)...
September 2016: Rivista di Psichiatria
https://www.readbyqxmd.com/read/27858594/the-attitudes-of-nursing-students-to-euthanasia
#11
Ladan Naseh, Mohammad Heidari
One of the most common morally controversial issues in endof-life care is euthanasia. Examining the attitudes of nursing students to this issue is important because they may encounter situations related to euthanasia during their clinical courses. The aim of our study was to examine nursing students' attitudes to euthanasia in Shahrekord city in western Iran. This was done using the Euthanasia Attitude Scale. The scale is divided into four categories, ie ethical considerations, practical considerations, treasuring life and naturalistic beliefs...
October 28, 2016: Indian Journal of Medical Ethics
https://www.readbyqxmd.com/read/27851777/moralized-rationality-relying-on-logic-and-evidence-in-the-formation-and-evaluation-of-belief-can-be-seen-as-a-moral-issue
#12
Tomas Ståhl, Maarten P Zaal, Linda J Skitka
In the present article we demonstrate stable individual differences in the extent to which a reliance on logic and evidence in the formation and evaluation of beliefs is perceived as a moral virtue, and a reliance on less rational processes is perceived as a vice. We refer to this individual difference variable as moralized rationality. Eight studies are reported in which an instrument to measure individual differences in moralized rationality is validated. Results show that the Moralized Rationality Scale (MRS) is internally consistent, and captures something distinct from the personal importance people attach to being rational (Studies 1-3)...
2016: PloS One
https://www.readbyqxmd.com/read/27849489/early-intervention-for-post-traumatic-stress-disorder-depression-and-quality-of-life-in-mortuary-affairs-soldiers-postdeployment
#13
Quinn M Biggs, Carol S Fullerton, James E McCarroll, Xian Liu, Leming Wang, Nicole M Dacuyan, Douglas F Zatzick, Robert J Ursano
U.S. Army mortuary affairs (MA) soldiers experience stressors of deployment and exposure to the dead, increasing risk for post-traumatic stress and depression. This study examines Troop Education for Army Morale, a postdeployment early intervention based on Psychological First Aid. MA soldiers (N = 126) were randomized to intervention or comparison groups 1-month postdeployment. Intervention sessions were held at 2, 3, 4, and 7 months. Assessments of post-traumatic stress disorder (PTSD), depression, and quality of life (QOL) were conducted at 1, 2, 3, 4, 7, and 10 months for both groups...
November 2016: Military Medicine
https://www.readbyqxmd.com/read/27835719/adjunctive-taurine-in-first-episode-psychosis-a-phase-2-double-blind-randomized-placebo-controlled-study
#14
Colin P O'Donnell, Kelly A Allott, Brendan P Murphy, Hok Pan Yuen, Tina-Marie Proffitt, Alicia Papas, Jennifer Moral, Tee Pham, Michaela K O'Regan, Christina Phassouliotis, Raelene Simpson, Patrick D McGorry
OBJECTIVE: Taurine is an inhibitory neuromodulatory amino acid in the central nervous system that activates the GABA- and glycine-insensitive chloride channel and inhibits the N-methyl-d-aspartate receptor. It also functions as a neuroprotective agent and has a role in neural development and neurogenesis. The aim of this study was to determine the efficacy of adjunctive taurine in improving symptomatology and cognition among patients with a DSM-IV first-episode psychotic disorder. METHODS: 121 patients with first-episode psychosis, aged 18-25 years, attending early intervention services consented to participate in this randomized, double-blind, placebo-controlled trial conducted from January 2007 to May 2009...
November 8, 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/27834281/factors-that-impact-on-emergency-nurses-ethical-decision-making-ability
#15
Barbara Alba
BACKGROUND: Reliance on moral principles and professional codes has given nurses direction for ethical decision-making. However, rational models do not capture the emotion and reality of human choice. Intuitive response must be considered. RESEARCH PURPOSE: Supporting intuition as an important ethical decision-making tool for nurses, the aim of this study was to determine relationships between intuition, years of worked nursing experience, and perceived ethical decision-making ability...
November 10, 2016: Nursing Ethics
https://www.readbyqxmd.com/read/27828789/improving-teamwork-and-resiliency-of-burn-center-nurses-through-a-standardized-staff-development-program
#16
Mollie F Christiansen, Andrew Wallace, John M Newton, Nicole Caldwell, Elizabeth A Mann-Salinas
For many acute care nursing units, such as the Burn Progressive Care Unit (BPCU) at the U.S. Army Burn center, staff stress and burnout is always a concern for leaders. Job stress not only contributes to nursing turnover, but can have a negative impact on patient care. The purpose of this project was to develop a training platform for nursing staff education and teambuilding with the intent of improving nurse satisfaction, increasing resiliency, building unit cohesion, enhancing morale, and increasing staff awareness of unit performance...
November 7, 2016: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/27815753/pediatric-ethics-and-communication-excellence-peace-rounds-decreasing-moral-distress-and-patient-length-of-stay-in-the-picu
#17
Lucia Wocial, Veda Ackerman, Brian Leland, Brian Benneyworth, Vinit Patel, Yan Tong, Mara Nitu
This paper describes a practice innovation: the addition of formal weekly discussions of patients with prolonged PICU stay to reduce healthcare providers' moral distress and decrease length of stay for patients with life-threatening illnesses. We evaluated the innovation using a pre/post intervention design measuring provider moral distress and comparing patient outcomes using retrospective historical controls. Physicians and nurses on staff in our pediatric intensive care unit in a quaternary care children's hospital participated in the evaluation...
November 4, 2016: HEC Forum: An Interdisciplinary Journal on Hospitals' Ethical and Legal Issues
https://www.readbyqxmd.com/read/27809825/becoming-partners-retaining-autonomy-ethical-considerations-on-the-development-of-precision-medicine
#18
Alessandro Blasimme, Effy Vayena
Precision medicine promises to develop diagnoses and treatments that take individual variability into account. According to most specialists, turning this promise into reality will require adapting the established framework of clinical research ethics, and paying more attention to participants' attitudes towards sharing genotypic, phenotypic, lifestyle data and health records, and ultimately to their desire to be engaged as active partners in medical research.Notions such as participation, engagement and partnership have been introduced in bioethics debates concerning genetics and large-scale biobanking to broaden the focus of discussion beyond individual choice and individuals' moral interests...
November 4, 2016: BMC Medical Ethics
https://www.readbyqxmd.com/read/27797570/moral-distress-in-physicians-and-nurses-impact-on-professional-quality-of-life-and-turnover
#19
Cindy L Austin, Robert Saylor, Phillip J Finley
Objective: The purpose of this study was to investigate moral distress (MD) and turnover intent as related to professional quality of life in physicians and nurses at a tertiary care hospital. Method: Health care providers from a variety of hospital departments anonymously completed 2 validated questionnaires (Moral Distress Scale-Revised and Professional Quality of Life Scale). Compassion fatigue (as measured by secondary traumatic stress [STS] and burnout [BRN]) and compassion satisfaction are subscales which make up one's professional quality of life...
October 31, 2016: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/27797560/not-all-risks-are-created-equal-a-twin-study-and-meta-analyses-of-risk-taking-across-seven-domains
#20
X T Xiao-Tian Wang, Rui Zheng, Yan-Hua Xuan, Jie Chen, Shu Li
Humans routinely deal with both traditional and novel risks. Different kinds of risks have been a driving force for both evolutionary adaptations and personal development. This study explored the genetic and environmental influences on human risk taking in different task domains. Our approach was threefold. First, we integrated several scales of domain-specific risk-taking propensity and developed a synthetic scale, including both evolutionarily typical and modern risks in the following 7 domains: cooperation/competition, safety, reproduction, natural/physical risk, moral risk, financial risk, and gambling...
November 2016: Journal of Experimental Psychology. General
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