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https://www.readbyqxmd.com/read/29766299/molecularly-defined-diffuse-leptomeningeal-glioneuronal-tumor-dlgnt-comprises-two-subgroups-with-distinct-clinical-and-genetic-features
#1
Maximilian Y Deng, Martin Sill, Jason Chiang, Jens Schittenhelm, Martin Ebinger, Martin U Schuhmann, Camelia-Maria Monoranu, Till Milde, Andrea Wittmann, Christian Hartmann, Clemens Sommer, Werner Paulus, Jutta Gärtner, Wolfgang Brück, Thomas Rüdiger, Alfred Leipold, Zane Jaunmuktane, Sebastian Brandner, Felice Giangaspero, Paolo Nozza, Jaume Mora, Andres Morales la Madrid, Ofelia Cruz Martinez, Jordan R Hansford, Torsten Pietsch, Anna Tietze, Pablo Hernáiz-Driever, Iris Stoler, David Capper, Andrey Korshunov, David W Ellison, Andreas von Deimling, Stefan M Pfister, Felix Sahm, David T W Jones
Diffuse leptomeningeal glioneuronal tumors (DLGNT) represent rare CNS neoplasms which have been included in the 2016 update of the WHO classification. The wide spectrum of histopathological and radiological features can make this enigmatic tumor entity difficult to diagnose. In recent years, large-scale genomic and epigenomic analyses have afforded insight into key genetic alterations occurring in multiple types of brain tumors and provide unbiased, complementary tools to improve diagnostic accuracy. Through genome-wide DNA methylation screening of > 25,000 tumors, we discovered a molecularly distinct class comprising 30 tumors, mostly diagnosed histologically as DLGNTs...
May 15, 2018: Acta Neuropathologica
https://www.readbyqxmd.com/read/29756034/toward-tailoring-majorana-bound-states-in-artificially-constructed-magnetic-atom-chains-on-elemental-superconductors
#2
Howon Kim, Alexandra Palacio-Morales, Thore Posske, Levente Rózsa, Krisztián Palotás, László Szunyogh, Michael Thorwart, Roland Wiesendanger
Realizing Majorana bound states (MBS) in condensed matter systems is a key challenge on the way toward topological quantum computing. As a promising platform, one-dimensional magnetic chains on conventional superconductors were theoretically predicted to host MBS at the chain ends. We demonstrate a novel approach to design of model-type atomic-scale systems for studying MBS using single-atom manipulation techniques. Our artificially constructed atomic Fe chains on a Re surface exhibit spin spiral states and a remarkable enhancement of the local density of states at zero energy being strongly localized at the chain ends...
May 2018: Science Advances
https://www.readbyqxmd.com/read/29754895/drug-consumption-rooms-comparing-times-spaces-and-actors-in-issues-of-social-acceptability-in-french-public-debate
#3
Marie Jauffret-Roustide, Isabelle Cailbault
BACKGROUND: In October 2016, the first French drug consumption room (DCR) opened in Paris. We propose to examine the process through which this issue has been framed as a matter of public concern, after being ignored for almost 20 years. Our analysis of the controversy on DCRs investigates how public conversations on harm reduction evolve according to the time period (from the 1990s to the present), scale of discourse (local vs. national), and involved actors (politicians, professionals, local residents, and drug users)...
May 10, 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29730714/health-status-among-long-term-breast-cancer-survivors-suffering-from-higher-levels-of-fatigue-a-cross-sectional-study
#4
Francisco Álvarez-Salvago, Noelia Galiano-Castillo, Manuel Arroyo-Morales, Mayra Cruz-Fernández, Mario Lozano-Lozano, Irene Cantarero-Villanueva
PURPOSE: The aims of this study were to evaluate the health status of long-term breast cancer survivors (LTBCS) suffering from higher levels of fatigue, to highlight their needs, and to establish the key points of intervention support programs. METHODS: A cross-sectional observational study was conducted at the Sport and Health Joint University Institute (iMUDS) between September 2016 and July 2017 with 80 LTBCS that were classified into non-fatigued (≤ 3.9) or fatigued (≥ 4) according to the Piper Fatigue Scale (PFS) total score...
May 5, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29729404/microfluidic-assisted-bacteriophage-encapsulation-into-liposomes
#5
Sharon S Y Leung, Sandra Morales, Warwick Britton, Elizabeth Kutter, Hak-Kim Chan
Microfluidics has recently emerged as a new method of manufacturing liposomes, which allows reproducible mixing in miliseconds on the nanoliter scale. Here we investigated the feasibility of a microfluidic flow focusing setup built from commercially available fittings to encapsulate phages into liposomes. Two types of Pseudomonas phages, PEV2 (Podovirus, ∼65 nm) and PEV40 (Myovirus, ∼220 nm), were used as model phages. A mixture of soy phosphatidylcholine and cholesterol at a ratio of 4:1 dissolved in absolute ethanol with a total solid content of 17...
May 2, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29724388/external-validation-of-ado-dose-cote-and-codex-at-predicting-death-in-primary-care-patients-with-copd-using-standard-and-machine-learning-approaches
#6
Daniel R Morales, Rob Flynn, Jianguo Zhang, Emmanuel Trucco, Jennifer K Quint, Kris Zutis
BACKGROUND: Several models for predicting the risk of death in people with chronic obstructive pulmonary disease (COPD) exist but have not undergone large scale validation in primary care. The objective of this study was to externally validate these models using statistical and machine learning approaches. METHODS: We used a primary care COPD cohort identified using data from the UK Clinical Practice Research Datalink. Age-standardised mortality rates were calculated for the population by gender and discrimination of ADO (age, dyspnoea, airflow obstruction), COTE (COPD-specific comorbidity test), DOSE (dyspnoea, airflow obstruction, smoking, exacerbations) and CODEX (comorbidity, dyspnoea, airflow obstruction, exacerbations) at predicting death over 1-3 years measured using logistic regression and a support vector machine learning (SVM) method of analysis...
May 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29724113/impact-of-positive-pressure-treatment-of-the-airway-on-health-related-quality-of-life-in-elderly-patients-with-obstructive-sleep-apnea
#7
Jesús Serrano Merino, Luis Ángel Pérula de Torres, Wayne A Bardwell, Rafaela Muñoz Gómez, Ana Roldán Villalobos, Nuria Feu Collado, Roger Ruiz-Moral, Bernabé Jurado-Gámez
BACKGROUND: Obstructive sleep apnea (OSA) is a chronic illness that increases in prevalence with age. Treatment includes continuous positive airway pressure (CPAP) devices. Studies about the use of CPAP in the elderly are scarce. The main objective of this study is to determine whether CPAP contributes to improvement in health-related quality of life (HRQL) in elderly patients with OSA. METHOD: This was a prospective, pre-/postintervention assessment of a cohort of patients ≥65 years of age with OSA diagnosis by polysomnography who were being treated with CPAP and were physically independent and had good cognitive status...
January 1, 2018: Biological Research for Nursing
https://www.readbyqxmd.com/read/29705454/effects-of-a-hippotherapy-intervention-on-muscle-spasticity-in-children-with-cerebral-palsy-a-randomized-controlled-trial
#8
David Lucena-Antón, Ignacio Rosety-Rodríguez, Jose A Moral-Munoz
OBJECTIVE: The aim of the present study is to evaluate the effect of a 12 weeks hippotherapy intervention protocol on hip adductors spasticity in children with spastic cerebral palsy. DESIGN: Randomized controlled trial. SETTINGS/LOCATION: The intervention was conducted in an Equestrian and Therapeutic Association. Patients were recruited from a Rehabilitation Unit of Cerebral Palsy. SUBJECTS: A total of 44 children with spastic cerebral palsy (Gross Motor Function Classification System [GMFCS] levels IV-V; 28 boys and 16 girls; aged 8 years 10 months, SD 3 months) were assigned to a treatment (n = 22; mean age 9 years 6 months, SD 3 months) or a control group (n = 22; mean age 8 years 3 months, SD 3 months)...
May 2018: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/29701626/moral-distress-md-and-burnout-in-mental-health-nurses-a-multicenter-survey
#9
Fabiana Delfrate, Paolo Ferrara, Daniela Spotti, Stefano Terzoni, Giulia Lamiani, Eleonora Canciani, Loris Bonetti
INTRODUCTION: Moral Distress (MD) is a common experience among nurses and if it is not recognised and treated, it may lead to serious consequences on nurses' health and quality of care. MD has been studied in several healthcare contexts. However, there are only few studies on MD in psychiatry and in Italy there are no data in this field.  Objective: To assess the presence of MD among mental health nurses in Italy and verify whether there is a relationship between MD and burnout. METHODS: We conducted a multicentre survey among nurses of Mental Health services of four hospitals in Milan...
February 6, 2018: La Medicina del Lavoro
https://www.readbyqxmd.com/read/29698404/identifying-seasonal-mobility-profiles-from-anonymized-and-aggregated-mobile-phone-data-application-in-food-security
#10
Pedro J Zufiria, David Pastor-Escuredo, Luis Úbeda-Medina, Miguel A Hernandez-Medina, Iker Barriales-Valbuena, Alfredo J Morales, Damien C Jacques, Wilfred Nkwambi, M Bamba Diop, John Quinn, Paula Hidalgo-Sanchís, Miguel Luengo-Oroz
We propose a framework for the systematic analysis of mobile phone data to identify relevant mobility profiles in a population. The proposed framework allows finding distinct human mobility profiles based on the digital trace of mobile phone users characterized by a Matrix of Individual Trajectories (IT-Matrix). This matrix gathers a consistent and regularized description of individual trajectories that enables multi-scale representations along time and space, which can be used to extract aggregated indicators such as a dynamic multi-scale population count...
2018: PloS One
https://www.readbyqxmd.com/read/29696527/prevalence-and-characteristics-of-autism-spectrum-disorder-among-spanish-school-age-children
#11
Paula Morales-Hidalgo, Joana Roigé-Castellví, Carmen Hernández-Martínez, Núria Voltas, Josefa Canals
The present study aims to assess the prevalence of autism spectrum disorder (ASD) in preschool and school-age children following a two-phase procedure. The screening phase was performed on a sample of 5555 children taking into account parent and teacher information. The individual assessment included the ADI-R, ADOS-2 and Wechsler scales. The estimated prevalence was 1.55% in preschoolers and 1.00% in school-age children. Between 1.84 and 2.59% of the children exhibited subclinical diagnosis. The male-to-female ratio was around 4:1...
April 25, 2018: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29695198/effect-of-moral-empowerment-program-on-moral-distress-in-intensive-care-unit-nurses
#12
Safura Abbasi, Somayeh Ghafari, Mohsen Shahriari, Nahid Shahgholian
BACKGROUND: Moral distress has been experienced by about 67% of critical care nurses which causes many complications such as job dissatisfaction, loss of capacity for caring, and turnover for nurses and poor quality of care for patients as well as health system. OBJECTIVE: The purpose of this research was to provide a moral empowerment program to nursing directors, school of nursing, and the heads of hospitals to reduce moral distress in nurses and improve the quality of care...
January 1, 2018: Nursing Ethics
https://www.readbyqxmd.com/read/29689380/mpa-a-free-accessible-and-efficient-pipeline-for-single-nucleotide-variant-annotation-and-prioritization-for-next-generation-sequencing-routine-molecular-diagnosis
#13
Kevin Yauy, David Baux, Henri Pegeot, Charles Van Goethem, Charly Mathieu, Thomas Guignard, Raul Juntas Morales, Delphine Lacourt, Martin Krahn, Vilma-Lotta Lehtokari, Gisele Bonne, Sylvie Tuffery-Giraud, Michel Koenig, Mireille Cossée
Interpretation of next-generation sequencing data constitutes the main limitation in molecular genetics diagnosis. In diagnosis of myopathies and muscular dystrophies (MMD), another major issue is to efficiently predict pathogenicity of variants identified in large genes, especially TTN, since current in silico prediction tools show limitations to predict and rank the numerous variants of such genes. We propose a unique variant prioritization score called mobidic prioritization algorithm (MPA) based on curated interpretation for previously reported variants, biological assumptions, and splice and missense predictors to prioritize all types of single nucleotide variants...
April 21, 2018: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/29681643/prevalence-of-alexithymia-in-eating-disorders-in-a-clinical-sample-of-800-mexican-patients
#14
Jorge Armando Barriguete-Meléndez, Ana Pérez-Bustinzar, Rocío Ivonne de la Vega-Morales, José Ángel Córdova-Villalobos, Jorge Manuel Sánchez-González, Paola Barriguete-Chávez Peón, Luis Rojo-Moreno
Introduction: The inability to identify, express feelings, and not distinguish between emotions and bodily sensations, is known as alexithymia. In 1988, it developed The Toronto Alexithymia Scale (TAS-20), consists of 20 items and three factors: a) difficulty of identifying feelings and differences between feelings and bodily sensations; b) difficulty of describing feelings; and c) externally oriented thinking. It's considered that people with eating disorders have specific deficits in identify and communicate their feelings...
2018: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/29675703/vertical-and-seasonal-patterns-control-bacterioplankton-communities-at-two-horizontally-coherent-coastal-upwelling-sites-off-galicia-nw-spain
#15
Víctor Hernando-Morales, Marta M Varela, David M Needham, Jacob Cram, Jed A Fuhrman, Eva Teira
Analysis of seasonal patterns of marine bacterial community structure along horizontal and vertical spatial scales can help to predict long-term responses to climate change. Several recent studies have shown predictable seasonal reoccurrence of bacterial assemblages. However, only a few have assessed temporal variability over both horizontal and vertical spatial scales. Here, we simultaneously studied the bacterial community structure at two different locations and depths in shelf waters of a coastal upwelling system during an annual cycle...
April 19, 2018: Microbial Ecology
https://www.readbyqxmd.com/read/29669617/does-a-modified-mindfulness-based-cognitive-therapy-mbct-course-have-the-potential-to-reduce-stress-and-burnout-in-nhs-gps-feasibility-study
#16
Kate Hamilton-West, Tracy Pellatt-Higgins, Neil Pillai
AimTo explore, for the first time, whether a modified mindfulness-based cognitive therapy (MBCT) course has the potential to reduce stress and burnout among National Health Service (NHS) General Practitioners. BACKGROUND: There is a crisis of low morale among NHS GPs, with most describing their workload as 'unmanageable'. MBCT has been demonstrated to improve stress and burnout in other populations, but has not yet been evaluated in a cohort of NHS GPs. METHODS: NHS GPs in South East England (n=22) attended a modified version of the MBCT course approved by National Institute for Health and Care Excellence for prevention of depressive relapse...
April 19, 2018: Primary Health Care Research & Development
https://www.readbyqxmd.com/read/29669185/distinct-trauma-types-in-military-service-members-seeking-treatment-for-posttraumatic-stress-disorder
#17
Brett T Litz, Ateka A Contractor, Charla Rhodes, Katherine A Dondanville, Alexander H Jordan, Patricia A Resick, Edna B Foa, Stacey Young-McCaughan, Jim Mintz, Jeffrey S Yarvis, Alan L Peterson
We examined the frequency of trauma types reported in a cohort of service members seeking treatment for posttraumatic stress disorder (PTSD) and compared symptom profiles between types. In this observational study, 999 service members (9.2% women; Mage = 32.91 years; 55.6% White) were evaluated using a standardized assessment procedure to determine eligibility for clinical trials. Participants were evaluated for DSM-IV-TR-defined PTSD using the PTSD Symptom Scale-Interview; all participants reported a Criterion A event...
April 2018: Journal of Traumatic Stress
https://www.readbyqxmd.com/read/29662500/genetic-resources-in-the-calabaza-pipiana-squash-cucurbita-argyrosperma-in-mexico-genetic-diversity-genetic-differentiation-and-distribution-models
#18
Guillermo Sánchez-de la Vega, Gabriela Castellanos-Morales, Niza Gámez, Helena S Hernández-Rosales, Alejandra Vázquez-Lobo, Erika Aguirre-Planter, Juan P Jaramillo-Correa, Salvador Montes-Hernández, Rafael Lira-Saade, Luis E Eguiarte
Analyses of genetic variation allow understanding the origin, diversification and genetic resources of cultivated plants. Domesticated taxa and their wild relatives are ideal systems for studying genetic processes of plant domestication and their joint is important to evaluate the distribution of their genetic resources. Such is the case of the domesticated subspecies C. argyrosperma ssp. argyrosperma , known in Mexico as calabaza pipiana , and its wild relative C. argyrosperma ssp. sororia . The main aim of this study was to use molecular data (microsatellites) to assess the levels of genetic variation and genetic differentiation within and among populations of domesticated argyrosperma across its distribution in Mexico in comparison to its wild relative, sororia , and to identify environmental suitability in previously proposed centers of domestication...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29658728/-beyond-sacrificial-harm-a-two-dimensional-model-of-utilitarian-psychology-correction
#19
(no author information available yet)
Reports an error in "Beyond Sacrificial Harm: A Two-Dimensional Model of Utilitarian Psychology" by Guy Kahane, Jim A. C. Everett, Brian D. Earp, Lucius Caviola, Nadira S. Faber, Molly J. Crockett and Julian Savulescu ( Psychological Review , Advanced Online Publication, Dec 21, 2017, np). The copyright attribution was incorrectly listed, and the Creative Commons CC-BY license disclaimer was incorrectly omitted from the author note. The correct copyright is "© 2017 The Author(s)" and the omitted disclaimer is presented in the erratum...
March 2018: Psychological Review
https://www.readbyqxmd.com/read/29649022/effectiveness-of-chinese-martial-arts-and-philosophy-to-reduce-reactive-and-proactive-aggression-in-schoolchildren
#20
Annis Lai Chu Fung, Toney Ka Hung Lee
OBJECTIVE: This study examined the effectiveness of Chinese martial arts in reducing reactive and proactive aggressive behavior among schoolchildren with a cluster-randomized trial. METHODS: A screening questionnaire was completed by 3511 schoolchildren of Grades 2 to 5 from 13 sites in Hong Kong. We shortlisted 298 children who scored z ≥ 1 on the total score of the Reactive-Proactive Aggression Questionnaire in their respective sites to participate in the experiment...
April 10, 2018: Journal of Developmental and Behavioral Pediatrics: JDBP
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