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https://www.readbyqxmd.com/read/29169211/simultaneous-determination-of-kaempferol-quercetin-mangiferin-gallic-acid-p-hydroxybenzoic-acid-and-chlorpheniramine-maleate-in-rat-plasma-after-oral-administration-of-mang-guo-zhi-ke-tablets-by-uhplc-ms-ms-and-its-application-to-pharmacokinetics
#1
Weijie Xu, Jiagang Deng, Yiyun Qian, Xiao-Tao Hou, Zhenhua Zhu, Ming Zhao, Erxin Shang, Dawei Qian, Huiting Zeng, Hanqing Pang, Jinao Duan
Mang-Guo-Zhi-Ke Tablets (MGZKTS) is an effective Chinese patent medicine, contains mango leaf extract as the main raw material, and the antihistamine drug, chlorpheniramine maleate, is included in the formulation. However, its pharmacokinetic effect is rarely reported. A highly sensitive, reliable and rapid high-throughput method using ultra-high-performance liquid chromatography with tandem mass spectrometry (UHPLC-MS/MS) was used to simultaneously determine kaempferol, quercetin, mangiferin, p-hydroxybenzoic acid, gallic acid and chlorpheniramine maleate in rat plasma after oral administration of MGZKTS...
November 23, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29168961/differences-and-similarities-in-medicine-use-perceptions-and-sharing-among-adolescents-in-two-different-educational-settings
#2
Stense Vestergaard, Pernille Ravn, Christine Erikstrup Hallgreen, Susanne Kaae
Background Evidence suggests that there are differences in medicine habits among adolescents with different sociodemographic backgrounds and that peers might also influence medicine use. More knowledge is needed regarding how these aspects together affect how different young people use medicines. Objective To explore the differences in medicine use, perceptions and sharing between adolescents at two different educational (and socio-demographic) settings and assess the influence of parents and peers. Subjects Fifty-nine students from a private high school (HS) and 34 students from a public vocational school (VS) in Denmark between the ages of 15 and 19 years old were subjects in this study...
November 23, 2017: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/29168885/distribution-of-peripheral-dendritic-cells-in-patients-with-hbv-infection-or-spleen-and-kidney-deficiency
#3
Weixia Chen, Lei Wang, Yaofei Niu, Guang Ji, Lianjun Xing
AIMS: Spleen and kidney deficiency syndrome (SKD), a Traditional Chinese Medicine (TCM) syndrome, is the fundamental mechanisms of TCM. We aim to investigate the distribution of peripheral dendritic cells (DCs) in HBV patients with SKD or non-SKD. METHODS: Peripheral venous blood from patients with HBV infection and healthy volunteers was collected to extract PBMC, and flow cytometry assay was used to measure the distribution of DCs subsets, including myeloid dendritic cells (mDCs) and plasmacytoid dendritic cells (pDCs)...
November 23, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/29168401/the-clinical-benefit-of-hyperthermia-in-pancreatic-cancer-a-systematic-review
#4
Astrid van der Horst, Eva Versteijne, Marc G H Besselink, Joost G Daams, Esther B Bulle, Maarten F Bijlsma, Johanna W Wilmink, Otto M van Delden, Jeanin E van Hooft, Nicolaas A P Franken, Hanneke W M van Laarhoven, Johannes Crezee, Geertjan van Tienhoven
OBJECTIVE: In pancreatic cancer, which is therapy resistant due to its hypoxic microenvironment, hyperthermia may enhance the effect of radio(chemo)therapy. The aim of this systematic review is to investigate the validity of the hypothesis that hyperthermia added to radiotherapy and/or chemotherapy improves treatment outcome for pancreatic cancer patients. METHODS AND MATERIALS: We searched MEDLINE and Embase, supplemented by handsearching, for clinical studies involving hyperthermia in pancreatic cancer patients...
November 23, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29168239/evaluation-of-a-diagnostic-therapeutic-educational-pathway-for-asthma-management-in-youth
#5
Sebastiano Guarnaccia, Cristina Quecchia, Andrea Festa, Michele Magoni, Marco Moneda, Valeria Gretter, Carmelo Scarcella, Ada Pluda, Cinzia Gasparotti, Malica Frassine, Luigi Vitale, Emanuele D'Agata, Rosa Maria Limina, Francesco Donato
BACKGROUND: In spite of some evidence for positive effects of patient's education to asthma self-management by randomized clinical trials, there are few studies on the impact of patient' s educational programs in the real world. We aimed to assess the impact of a diagnostic therapeutic educational pathway (DTEP) on asthma control of children and adolescents by comparing frequency of outcomes indicative of asthma control before and after attending the pathway. METHODS: This is a retrospective cohort study including all patients aged 6-11 and 12-17 years who attended the DTEP in 2007-2014...
November 23, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29167693/approving-cancer-treatments-based-on-endpoints-other-than-overall-survival-an-analysis-of-historical-data-using-the-pace-continuous-innovation-indicators%C3%A2-cii
#6
Neon Brooks, Mario Campone, Silvia Paddock, Scott Shortenhaus, David Grainger, Jacqueline Zummo, Samuel Thomas, Rose Li
Background: There is an active debate about the role that endpoints other than overall survival (OS) should play in the drug approval process. Yet the term 'surrogate endpoint' implies that OS is the only critical metric for regulatory approval of cancer treatments. We systematically analyzed the relationship between U.S. Food and Drug Administration (FDA) approval and publication of OS evidence to understand better the risks and benefits of delaying approval until OS evidence is available...
2017: Drugs in Context
https://www.readbyqxmd.com/read/29167071/therapeutic-response-analysis-in-dogs-with-naturally-occurring-osteoarthritis
#7
Alexandre Gagnon, Dominique Brown, Maxim Moreau, Bertrand Lussier, Colombe Otis, Eric Troncy
OBJECTIVE: Reporting the rate of positive (+) and negative (-) responders based on an objective outcome measure of pain-related functional disability/lameness in dogs with naturally occurring osteoarthritis (OA), and the relationship between initial lameness severity and the odds of being a (+) responder. STUDY DESIGN: Retrospective analysis of published peer-reviewed clinical trials in dogs with naturally occurring OA. ANIMALS: Dogs (n = 213) with hip and/or stifle afflicted-joints...
September 15, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29166752/immunotherapy-treatment-an-issue-for-metabolic-response
#8
Luca Tagliabue, Antonella Capozza, Claudio Maioli, Andrea Luciani, Anna M Ierardi, Gianpaolo Carrafiello
Since the beginning of second decade of this century, when it was introduced in many oncologic scenarios, immunotherapy has become an important tool in the management of a growing number of cancers. Engaging the host immune system in cancer therapy seems to be useful, improving not only progression free survival but also overall survival, until the achieving the goal that many advanced cancers, previously considered without effective treatment options, have now become successfully treatable. Moreover, considering the relatively recent introduction of these drugs in clinical scenarios and the continuous releasing of new drugs, large validated clinical experiences are lacking and many issues are today debated; by the way, the evaluation of the response to immune-therapy poses major concerns...
November 22, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29165798/weight-management-and-physical-activity-throughout-the-cancer-care-continuum
#9
Wendy Demark-Wahnefried, Kathryn H Schmitz, Catherine M Alfano, Jennifer R Bail, Pamela J Goodwin, Cynthia A Thomson, Don W Bradley, Kerry S Courneya, Christie A Befort, Crystal S Denlinger, Jennifer A Ligibel, William H Dietz, Melinda R Stolley, Melinda L Irwin, Marcas M Bamman, Caroline M Apovian, Bernardine M Pinto, Kathleen Y Wolin, Rachel M Ballard, Andrew J Dannenberg, Elizabeth G Eakin, Matt M Longjohn, Susan D Raffa, Lucile L Adams-Campbell, Joanne S Buzaglo, Sharyl J Nass, Greta M Massetti, Erin P Balogh, Elizabeth S Kraft, Anand K Parekh, Darshak M Sanghavi, G Stephen Morris, Karen Basen-Engquist
Mounting evidence suggests that weight management and physical activity (PA) improve overall health and well being, and reduce the risk of morbidity and mortality among cancer survivors. Although many opportunities exist to include weight management and PA in routine cancer care, several barriers remain. This review summarizes key topics addressed in a recent National Academies of Science, Engineering, and Medicine workshop entitled, "Incorporating Weight Management and Physical Activity Throughout the Cancer Care Continuum...
November 22, 2017: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/29165401/systematic-overview-of-bacopa-monnieri-l-wettst-dominant-poly-herbal-formulas-in-children-and-adolescents
#10
REVIEW
James D Kean, Luke A Downey, Con Stough
Background: The Ayurvedic medicinal system employs a holistic approach to health, utilising the synergistic properties of organic resources. Research into the Ayurvedic herb Bacopa monnieri (L.) Wettst. (B.monnieri) has reported improvements in cognitive outcomes in child and adult populations. The aim of current review is to systematically assess and critically summarize clinical trials investigating B.monnieri-dominant poly-herbal formulas and their effects on the cognition, memory, learning, and behaviour in children and adolescents...
November 22, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/29165070/bortezomib-in-kidney-transplant-current-use-and-perspectives
#11
Lucio R Requião-Moura, Taina V de Sandes-Freitas, Gessika Marcelo-Gomes, Erika B Rangel
BACKGROUND: Despite major advances in transplant medicine, antibody-mediated rejection (AMR) continues to have severe clinical implications and adversely affect graft survival. Therefore, the search for alternative drugs to treat AMR is widely pursued. The first-in-class proteasome inhibitor bortezomib (BZ) is a selective inhibitor of the 26S proteasome, which was initially approved for the treatment of malignant plasma cell disorders. METHODS: This review encompasses how our understanding of inhibiting proteasome pathway created the basis of BZ research and important milestones accomplished in AMR treatment in the transplant setting...
November 20, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/29164947/trading-equality-for-health-evaluating-the-trade-off-and-institutional-hypotheses-on-health-inequalities-in-the-global-south
#12
Benjamin Sosnaud, Jason Beckfield
It has been suggested that as medicine advances and mortality declines, socioeconomic disparities in health outcomes will grow. Yet, most research on this topic uses data from affluent Western democracies, where mortality is declining in small increments. We argue that the Global South represents the ideal setting to study this issue in a context of rapid mortality decline. We evaluate two competing hypotheses: (1) there is a trade-off between population health and health inequality such that reductions in under-five mortality are linked to higher levels of social inequality in health; and (2) institutional interventions that improve under-five mortality, like the expansion of educational systems and public health expenditure, are associated with reductions in inequalities...
September 2017: Journal of Health and Social Behavior
https://www.readbyqxmd.com/read/29164803/preclinical-evaluation-and-optimization-of-a-cell-therapy-using-human-cord-blood-derived-endothelial-colony-forming-cells-for-ischemic-retinopathies
#13
Emma Reid, Jasenka Guduric-Fuchs, Christina L O'Neill, Lynsey-Dawn Allen, Sarah E J Chambers, Alan W Stitt, Reinhold J Medina
Cell therapy using endothelial progenitors holds promise for vascular repair in ischemic retinopathies. Using a well-defined subpopulation of human cord blood-derived endothelial progenitors known as endothelial colony-forming cells (ECFCs), we have evaluated essential requirements for further development of this cell therapy targeting the ischemic retina, including dose response, delivery route, and toxicity. First, to evaluate therapeutic efficacy relating to cell dose, ECFCs were injected into the vitreous of mice with oxygen-induced retinopathy...
November 22, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29164483/dosimetry-based-treatment-planning-for-molecular-radiotherapy-a-summary-of-the-2017-report-from-the-internal-dosimetry-task-force
#14
Caroline Stokke, Pablo Minguez Gabiña, Pavel Solný, Francesco Cicone, Mattias Sandström, Katarina Sjögreen Gleisner, Carlo Chiesa, Emiliano Spezi, Maria Paphiti, Mark Konijnenberg, Matt Aldridge, Jill Tipping, Michael Wissmeyer, Boudewijn Brans, Klaus Bacher, Carsten Kobe, Glenn Flux
BACKGROUND: The European directive on basic safety standards (Council directive 2013/59 Euratom) mandates dosimetry-based treatment planning for radiopharmaceutical therapies. The directive comes into operation February 2018, and the aim of a report produced by the Internal Dosimetry Task Force of the European Association of Nuclear Medicine is to address this aspect of the directive. A summary of the report is presented. RESULTS: A brief review of five of the most common therapy procedures is included in the current text, focused on the potential to perform patient-specific dosimetry...
November 21, 2017: EJNMMI Physics
https://www.readbyqxmd.com/read/29164163/neurocognitive-deficits-of-concussed-adolescent-athletes-at-self-reported-symptom-resolution-in-the-zurich-guidelines-era
#15
Peter K Kriz, Rebekah Mannix, Alex M Taylor, Danielle Ruggieri, William P Meehan
Background: Previous studies have evaluated high school and collegiate athletes in the pre-Zurich guidelines era; whether adolescent athletes demonstrate similar neurocognitive decrements in the current concussion management era remains unclear. Purpose: To assess for the presence of neurocognitive deficits in adolescents with a sport-related concussion at the time of self-reported symptom resolution. Study Design: Cross-sectional study; Level of evidence, 3...
November 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29164047/cost-of-tuberculosis-treatment-evidence-from-iran-s-health-system
#16
Vahid Bay, Payam Tabarsi, Aziz Rezapour, Sima Marzban, Ehsan Zarei
Objectives: This study aimed to estimate the cost of smear-positive drug-susceptible pulmonary tuberculosis (TB) treatment of the patients in the Azadshahr district, Golestan Province, Iran. Methods: In this retrospective study, all new smear positive pulmonary TB patients who had been registered at the district's health network between April, 2013 and December, 2015 and had successfully completed their treatment were entered into the study (45 patients). Treatment costs were estimated from the provider's perspective using an activity-based costing (ABC) method...
October 2017: Osong Public Health and Research Perspectives
https://www.readbyqxmd.com/read/29164037/guidelines-for-the-management-of-degenerative-cervical-myelopathy-and-acute-spinal-cord-injury-development-process-and-methodology
#17
Lindsay A Tetreault, Andrea C Skelly, Joseph R Dettori, Jefferson R Wilson, Allan R Martin, Michael G Fehlings
The Institute of Medicine defines clinical practice guidelines as "statements that include recommendations intended to optimize patient care that are informed by a systematic review of evidence and an assessment of the benefits and harms of alternative care options." Guidelines help clinicians implement best evidence into practice and encourage informed shared decision making with patients. Guidelines are intended to enhance the quality of patient care by discouraging ineffective and potentially harmful interventions and standardizing practice...
September 2017: Global Spine Journal
https://www.readbyqxmd.com/read/29163799/jak2-aberrations-in-childhood-b-cell-precursor-acute-lymphoblastic-leukemia
#18
Elisabeth M P Steeghs, Isabel S Jerchel, Willemieke de Goffau-Nobel, Alex Q Hoogkamer, Judith M Boer, Aurélie Boeree, Cesca van de Ven, Marco J Koudijs, Nicolle J M Besselink, Hester A de Groot-Kruseman, Christian Michel Zwaan, Martin A Horstmann, Rob Pieters, Monique L den Boer
JAK2 abnormalities may serve as target for precision medicines in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL). In the current study we performed a screening for JAK2 mutations and translocations, analyzed the clinical outcome and studied the efficacy of two JAK inhibitors in primary BCP-ALL cells. Importantly, we identify a number of limitations of JAK inhibitor therapy. JAK2 mutations mainly occurred in the poor prognostic subtypes BCR-ABL1-like and non- BCR-ABL1-like B-other (negative for sentinel cytogenetic lesions)...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29163736/association-of-glycosylated-hemoglobin-levels-with-vitamin-d-status
#19
Badurudeen Mahmood Buhary, Ohoud Almohareb, Naji Aljohani, Saleh Alrajhi, Samer Elkaissi, Suphia Sherbeeni, Abdulrahman Almaghamsi, Shawana Abdulhamid Khan, Mussa H Almalki
Background: The discovery of vitamin D is one of medicine's great achievements. Despite all the positive evidence emerging about the beneficial effect of vitamin D, we still find many are vitamin D deficient. The purposes of this study were to examine the association between serum 25-hydroxyvitamin D (25(OH)D) and glycosylated hemoglobin (HbA1c) levels, to test the hypothesis that lower 25(OH)D levels are associated with poorer glucose control in diabetes mellitus (DM) patients and to investigate the effect of vitamin D supplementation on HbA1c levels...
December 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29163703/the-downregulation-of-c-myc-and-its-target-gene-htert-is-associated-with-the-antiproliferative-effects-of-baicalin-on-hl-60-cells
#20
Xia Ren, Zhiyong Zhang, Jing Tian, Hengxiao Wang, Guanhua Song, Qiang Guo, Jing Tian, Yang Han, Qiong Liao, Guoqiang Liu, Huifang Ding, Guosheng Jiang
Baicalin is a flavonoid compound isolated from Scutellaria baicalensis, a Chinese traditional medicinal herb, and is used as an anti-inflammatory, antibacterial, anxiolytic and hepatoprotective drug. Accumulating evidence has demonstrated that baicalin exhibits potent antitumor properties by suppressing cell growth, arresting cell cycle progression and inducing differentiation or apoptosis in leukemia cell lines. However, whether or not the extrinsic pathway is involved in baicalin-induced apoptosis of leukemia cells and the mechanisms underlying the antitumor activity of baicalin remain unclear...
December 2017: Oncology Letters
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