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Pediatric renal function

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https://www.readbyqxmd.com/read/28087255/unknown-face-of-known-drugs-what-else-can-we-expect-from-angiotensin-converting-enzyme-inhibitors
#1
REVIEW
Anna Wzgarda, Robert Kleszcz, Monika Prokop, Katarzyna Regulska, Milosz Regulski, Jaroslaw Paluszczak, Beata J Stanisz
The renin-angiotensin system (RAS) is one of important systems among homeostatic mechanisms that control the function of cardiovascular, renal and adrenal systems. As RAS has a very complex nature, it has been also found as related to the control of cell migration and apoptosis. Angiotensin-converting enzyme inhibitors (ACEI) are drugs most commonly used in the modulation of RAS activity. ACEI have been extensively described as effective in the treatment of hypertension among adults, but also as drugs delaying progression in diabetic nephropathy and reducing mortality in left ventricular dysfunction and congestive heart failure...
January 10, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27997529/renal-dysfunction-in-early-adulthood-following-birth-asphyxia-in-male-spiny-mice-and-its-amelioration-by-maternal-creatine-supplementation-during-pregnancy
#2
Stacey J Ellery, Domenic A LaRosa, Luise Cullen-McEwen, Russell D Brown, Rod J Snow, David W Walker, Michelle M Kett, Hayley Dickinson
BACKGROUND: Acute Kidney Injury (AKI) affects ~70% of asphyxiated newborns, and increases their risk of developing chronic kidney disease (CKD) later in life. AKI is driven by renal oxygen deprivation during asphyxia, thus we hypothesized that creatine administered antenatally would protect the kidney from the long-term effects of birth asphyxia. METHODS: Pregnant spiny mice were fed standard chow or chow supplemented with 5% creatine from 20-days gestation (mid-getstation)...
December 20, 2016: Pediatric Research
https://www.readbyqxmd.com/read/27995362/-pro-renin-and-pro-renin-receptor-expression-during-kidney-development-in-neonates
#3
Tomomasa Terada, Maki Urushihara, Takahiko Saijo, Ryuji Nakagawa, Shoji Kagami
: Although a recent study demonstrated that the (pro)renin receptor ((P)RR) was highly expressed in the developing kidney during the mouse embryonic development, the mechanism by which (P)RR supports renal development in humans is not fully understood. In this study, we examined the plasma levels of (pro)renin and soluble (P)RR (s(P)RR) in cord blood and neonates as well as (P)RR expression in human kidney tissues. Samples were collected from 57 preterm and 67 full-term human neonates...
February 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/27966809/delayed-elimination-of-high-dose-methotrexate-and-use-of-carboxypeptidase-g2-in-pediatric-patients-during-treatment-for-acute-lymphoblastic-leukemia
#4
Thommy Svahn, Karin Mellgren, Arja Harila-Saari, Ann Åsberg, Jukka Kanerva, Ólafur Jónsson, Goda Vaitkeviciene, Torben Stamm Mikkelssen, Kjeld Schmiegelow, Jesper Heldrup
BACKGROUND: Carboxypeptidase G2 (CPDG2 ) can be used as rescue treatment in cases of delayed methotrexate elimination (DME) and Mtx-induced nephrotoxicity. PROCEDURE: Between July 2008 and December 2014, all children (1.0-17.9 years) in the Nordic countries diagnosed with Philadelphia chromosome negative acute lymphoblastic leukemia (ALL) were treated according to the Nordic Organization for Pediatric Hematology and Oncology (NOPHO) ALL 2008 protocol, including administration of six to eight high-dose (5 g/m(2) /24 hr) Mtx (HDMtx) courses...
December 14, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27966039/magnetic-resonance-tissue-phase-mapping-demonstrates-altered-left-ventricular-diastolic-function-in-children-with-chronic-kidney-disease
#5
Charlotte Gimpel, Bernd A Jung, Sabine Jung, Johannes Brado, Daniel Schwendinger, Barbara Burkhardt, Martin Pohl, Katja E Odening, Julia Geiger, Raoul Arnold
BACKGROUND: Echocardiographic examinations have revealed functional cardiac abnormalities in children with chronic kidney disease. OBJECTIVE: To assess the feasibility of MRI tissue phase mapping in children and to assess regional left ventricular wall movements in children with chronic kidney disease. MATERIALS AND METHODS: Twenty pediatric patients with chronic kidney disease (before or after renal transplantation) and 12 healthy controls underwent tissue phase mapping (TPM) to quantify regional left ventricular function through myocardial long (Vz) and short-axis (Vr) velocities at all 3 levels of the left ventricle...
December 13, 2016: Pediatric Radiology
https://www.readbyqxmd.com/read/27938596/-focal-segmental-glomerulosclerosis-after-renal-transplantation-in-a-child-with-anca-associated-glomerulonephritis-case-report-and-literature-review
#6
L P Rong, L Z Chen, Q Fu, W F Chen, L Z Sun, X Y Jiang, Y Mo
Objective: To study the clinical features and treatment of focal segmental glomerulosclerosis (FSGS) after renal transplantation in a child with ANCA-associated glomerulonephritis. Method: The clinical and pathological data of the patient treated in the Department of Pediatrics as well as in the Department of Organ Transplantation in November 2015 in the First Affiliated Hospital of Sun Yat-sen University, who was diagnosed with de novo FSGS after renal transplantation with a primary disease ANCA-associated glomerulonephritis, was analyzed retrospectively...
December 2, 2016: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/27933438/acoustic-radiation-force-impulse-arfi-elastography-in-the-evaluation-of-renal-parenchymal-stiffness-in-patients-with-ureteropelvic-junction-obstruction
#7
Hatice Arioz Habibi, Rumeysa Yasemin Cicek, Sedat Giray Kandemirli, Emel Ure, Ayse Kalyoncu Ucar, Mine Aslan, Salim Caliskan, Ibrahim Adaletli
PURPOSE: To investigate the role of acoustic radiation force impulse (ARFI) elastography in the detection of renal parenchymal damage in kidneys with and without ureteropelvic junction obstruction (UPJO). METHODS: Twenty-five pediatric patients with a diagnosis of UPJO who underwent surgery and 15 pediatric patients with conservatively managed UPJO were prospectively evaluated with ARFI elastography. Sixteen healthy volunteers constituted the control group. Shear wave velocity (SWV) measurements in the upper, mid, and lower poles of the affected kidney were performed...
December 8, 2016: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/27932116/surgical-complications-in-en-bloc-renal-transplantation
#8
M A Moreno de la Higuera Díaz, N Calvo Romero, I Pérez-Flores, M Calvo Arévalo, B Rodríguez Cubillo, A Shabaka, V López de la Manzanara, Á Gómez Vegas, J Blázquez Izquierdo, A I Sánchez-Fructuoso
En bloc pediatric transplantation (EBPT) began with the aim of increasing the donor pool due to the existing high demand for donors. At its inception, it was considered a type of suboptimal transplantation due to its association with a high incidence of vascular, urologic, and immunologic complications. The main objective of this study was to update information on EBPT with the largest case series that exists on a worldwide scale. In a retrospective study, the results obtained from brain-dead donors (BDDs; n = 770) were compared to those of EBPT (n = 100) from January 1990 to December 2012...
November 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27916450/dramatic-response-after-functional-hemispherectomy-in-a-patient-with-epileptic-encephalopathy-carrying-a-de-novo-col4a1-mutation
#9
Naomi Hino-Fukuyo, Atsuo Kikuchi, Masaki Iwasaki, Yuko Sato, Yuki Kubota, Tomoko Kobayashi, Tojo Nakayama, Kazuhiro Haginoya, Natsuko Arai-Ichinoi, Tetsuya Niihori, Ryo Sato, Tasuku Suzuki, Hiroki Kudo, Ryo Funayama, Keiko Nakayama, Yoko Aoki, Shigeo Kure
We describe the first case of a successful functional hemispherectomy in a patient with epileptic encephalopathy and a de novo collagen type IV alpha 1 (COL4A1) mutation. A 4-year-old girl was COL4A1 mutation-positive and suffered from drug-resistant epilepsy, hemiplegia, and developmental delay. Magnetic resonance imaging detected no porencephaly, and she had no cataract or renal abnormality. Following a presurgical evaluation for epilepsy, she underwent a functional hemispherectomy. She has been seizure free with no intracranial hemorrhage or other perioperative complications...
December 1, 2016: Brain & Development
https://www.readbyqxmd.com/read/27900473/the-role-of-fluid-overload-in-the-prediction-of-outcome-in-acute-kidney-injury
#10
REVIEW
David T Selewski, Stuart L Goldstein
Our understanding of the epidemiology and the impact of acute kidney injury (AKI) and fluid overload on outcomes has improved significantly over the past several decades. Fluid overload occurs commonly in critically ill children with and without associated AKI. Researchers in pediatric AKI have been at the forefront of describing the impact of fluid overload on outcomes in a variety of populations. A full understanding of this topic is important as fluid overload represents a potentially modifiable risk factor and a target for intervention...
November 30, 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/27894119/trajectories-and-predictors-of-allograft-dysfunction-after-renal-transplantation-in-children
#11
Vandréa Carla de Souza, Muriel Rabilloud, Pierre Cochat, Mario Bernardes Wagner, Clotilde Druck Garcia, Bruno Ranchin, Jean Iwaz, Luciano Selistre, Laurence Dubourg
BACKGROUND: The survival rates of renal transplant children are indeed on the rise, but it is still important to ensure that there is optimal renal function in these children in all their future growing years. The number of functioning nephrons and the graft ability to adapt to an increasing demand during body growth seem to be the most important factors for long-term allograft function. This study examined the long-term change in the glomerular filtration rate in a pediatric kidney transplant cohort and the importance of the recipient and donor ages in predicting transplant outcome...
2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/27888411/to-screen-or-not-to-screen-for-vesicoureteral-reflux-in-children-with-ureteropelvic-junction-obstruction-a-systematic-review
#12
REVIEW
Marcus Weitz, Maria Schmidt
: Ureteropelvic junction obstruction (UPJO) and vesicoureteral reflux (VUR) are the most common uropathies. The co-occurrence of both anomalies has led to the practice of screening for VUR in children with UPJO to prevent deterioration of kidney function due to renal scarring following urinary tract infections (UTIs). We determined the prevalence of VUR in children with UPJO for a critical assessment of VUR screening by voiding cystourethrography (VCUG). A systematic search strategy in MEDLINE, EMBASE, and CENTRAL was carried out for all articles that included VCUG, and renal scintigraphy or any other appropriate imaging technique for the diagnosis of UPJO...
January 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/27878110/discontinuation-of-antimicrobial-prophylaxis-ap-in-children-with-spina-bifida-a-case-series-analysis
#13
Kevin G Couloures, Michael Anderson, Michael Machiorlatti, Olivera Marsenic, Lawrence Opas
BACKGROUND: Spina bifida increases the risk for urinary tract infections (UTI). Antimicrobial prophylaxis (AP) reduces symptomatic UTI's but selects resistant organisms. Measures to ensure regular and complete emptying of the bladder combined with treatment of constipation reduce the risk for UTI. OBJECTIVES: Demonstrate that close adherence to a catheterization regimen in children with spina bifida (Selective Treatment - ST) reduces the need for antimicrobial prophylaxis...
September 2016: Nephro-urology Monthly
https://www.readbyqxmd.com/read/27867846/what-s-the-best-minimal-invasive-approach-to-pediatric-nephrectomy-and-heminephrectomy-conventional-laparoscopy-cl-single-site-less-or-robotics-ras
#14
REVIEW
Holger Till, Ali Basharkhah, Andras Hock
BACKGROUND: Conventional laparoscopy (CL) using 3-5 mm ports has become the goldstandard for pediatric nephrectomy (N), heminephrectomy (HN) and heminephrecto-ureterectomy (HNU) for many years now. Recently the spectrum of minimal invasive surgery (MIS) has been extended by variants like laparoendoscopic single-site surgery (LESS) or robot-assisted surgery (RAS). However such technical developments tend to drive surgical euphoria and feasibility studies, but may miss adequate academic research about function and proven patients' benefits...
October 2016: Translational pediatrics
https://www.readbyqxmd.com/read/27861315/brincidofovir-is-not-a-substrate-for-the-human-organic-anion-transporter-1-oat1-a-mechanistic-explanation-for-the-lack-of-nephrotoxicity-observed-in-clinical-studies
#15
Timothy K Tippin, Marion E Morrison, Thomas M Brundage, Hervé Momméja-Marin
BACKGROUND: Brincidofovir (BCV) is an orally bioavailable lipid conjugate of cidofovir with increased in vitro potency relative to cidofovir against all five families of double-stranded DNA viruses that cause human disease. Following intravenous (IV) administration of cidofovir, the organic anion transporter 1 (OAT1) transports cidofovir from the blood into the renal proximal tubule epithelial cells with resulting dose-limiting nephrotoxicity. OBJECTIVE: To study whether OAT1 transports BCV and to evaluate the pharmacokinetic and renal safety profile of oral BCV compared with IV cidofovir...
November 16, 2016: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/27851688/brincidofovir-is-not-a-substrate-for-the-human-organic-anion-transporter-1-a-mechanistic-explanation-for-the-lack-of-nephrotoxicity-observed-in-clinical-studies
#16
Timothy K Tippin, Marion E Morrison, Thomas M Brundage, Hervé Momméja-Marin
BACKGROUND: Brincidofovir (BCV) is an orally bioavailable lipid conjugate of cidofovir (CDV) with increased in vitro potency relative to CDV against all 5 families of double-stranded DNA viruses that cause human disease. After intravenous (IV) administration of CDV, the organic anion transporter 1 (OAT1) transports CDV from the blood into the renal proximal tubule epithelial cells with resulting dose-limiting nephrotoxicity. OBJECTIVE: To study whether OAT1 transports BCV and to evaluate the pharmacokinetic and renal safety profile of oral BCV compared with IV CDV...
December 2016: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/27850949/1313-levosimendan-improved-renal-function-in-pediatric-patients-with-decompensated-heart-failure
#17
Alyaa Al Ali, Musaab Ramsi
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27849656/the-use-of-nesiritide-in-children-with-congenital-heart-disease
#18
Ronald A Bronicki, Michele Domico, Paul A Checchia, Curtis E Kennedy, Ayse Akcan-Arikan
OBJECTIVE: We evaluated the use of nesiritide in children with critical congenital heart disease, pulmonary congestion, and inadequate urine output despite conventional diuretic therapy. DESIGN: We conducted a retrospective analysis of 26 consecutive patients, comprising 37 infusions occurring during separate hospitalizations. Hemodynamic variables, urine output, and serum creatinine levels were monitored prior to and throughout the duration of therapy with nesiritide...
November 15, 2016: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/27836442/intravesical-ureteric-reimplantation-for-primary-obstructed-megaureter-in-infants-under-1-year-of-age
#19
Emily Jude, Aniruddh Deshpande, Andrew Barker, Japinder Khosa, Naeem Samnakay
PURPOSE: This study aimed to assess the outcome of intravesical ureteric reimplantation for primary obstructed megaureter (POM) performed in infants under 1 year of age. MATERIALS AND METHODS: A retrospective cohort study was carried out of all infants undergoing intravesical ureteric reimplantation surgery for POM at two pediatric centers in the 12 years between 2003 and 2014. Outcomes were compared with those of children aged over 1 year undergoing intravesical reimplantation for POM during this period...
October 24, 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/27829825/matrix-metalloproteinase-mmp-9-levels-in-children-on-hemodialysis-association-with-mmp-9-c-1562-t-gene-polymorphism-and-vitamin-d-levels
#20
Ashraf Galal, Fatina I Fadel, Enas Mokhtar, Manal F Elshamaa, Eman A Elghoroury, Solaf Kamel, Gamila S M Elsaeed, Eman H Thabet
BACKGROUND AND OBJECTIVES: Data concerning the concentration of matrix metalloproteinase-9 (MMP-9) and its functional polymorphisms in chronic kidney diseases (CKD) are conflicting. The present study aimed to evaluate the levels of MMP-9in children with end stage renal diseases (ESRD) on hemodialysis (HD) and to explore its association with MMP-9 polymorphism and vitamin D levels as an important risk factors for cardiovascular diseases (CVD). METHODS: We studied 55 children with ESRD on hemodialysis and 18 healthy children served as controls...
September 2016: International Journal of Biomedical Science: IJBS
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