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https://www.readbyqxmd.com/read/28817752/technical-refinements-and-outcomes-of-the-modified-anterior-septal-transplant
#1
Myriam Loyo, Jeffrey D Markey, Deniz Gerecci, Edward El Rassi, Ryan J Li, C Blake Sullivan, Tom D Wang
Importance: Severe anterior septal deviation and resultant nasal obstruction represent a difficult surgical task to correct. The goal of surgery is to straighten the anterior dorsal and caudal struts, while maintaining nasal tip and midvault support. This study presents a novel extracorporeal septoplasty technique to straighten the crooked anterior septum. Objective: To describe the novel anterior septal transplant technique, which consists of complete resection of the caudal septum and reconstruction with extended spreader grafts and a columellar strut, without a separate caudal septal replacement graft...
August 17, 2017: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/28817611/the-directed-migration-of-gonadal-distal-tip-cells-in-caenorhabditis-elegans-requires-ngat-1-a-%C3%A3-1-4-n-acetylgalactosaminyltransferase-enzyme
#2
Joseph Veyhl, Robert J Dunn, Wendy L Johnston, Alexa Bennett, Lijia W Zhang, James W Dennis, Harry Schachter, Joseph G Culotti
Glycoproteins such as growth factor receptors and extracellular matrix have well-known functions in development and cancer progression, however, the glycans at sites of modification are often heterogeneous molecular populations which makes their functional characterization challenging. Here we provide evidence for a specific, discrete, well-defined glycan modification and regulation of a stage-specific cell migration in Caenorhabditis elegans. We show that a chain-terminating, putative null mutation in the gene encoding a predicted β1,4-N-acetylgalactosaminyltransferase, named ngat-1, causes a maternally rescued temperature sensitive (ts) defect in the second phase of the three phase migration pattern of the posterior, but not the anterior, hermaphrodite Distal Tip Cell (DTC)...
2017: PloS One
https://www.readbyqxmd.com/read/28815683/phase-imaging-quality-improvement-by-modification-of-afm-probes-cantilever
#3
J Skibinski, J Rebis, L Kaczmarek, T Wejrzanowski, T Plocinski, K Rozniatowski
Imaging of the surface of materials by atomic force microscopy under tapping and phase imaging mode, with use of modified probes is addressed. In this study, the circularly shaped holes located in varying distance from the probe base, were cut out by focused ion beam. Such modification was a consequence of the results of the previous experiments (probe tip sharpening and cantilever thinning) where significant improvement of image quality in tapping and phase imaging mode has been revealed. The solution proposed herein gives similar results, but is much simpler from the technological point of view...
August 16, 2017: Journal of Microscopy
https://www.readbyqxmd.com/read/28803170/anatomy-of-the-alar-ligament-part-ii-variations-of-its-attachment-onto-the-dens
#4
Juan Sardi, Joe Iwanaga, Cameron Schmidt, Tarush Rustagi, Jens R Chapman, Rod J Oskouian, R Shane Tubbs
OBJECTIVE: Various authors have described the morphology of the alar ligaments, however, there are no reports of a cadaveric study that focuses on their attachments onto the dens. The purpose of this study is to use fresh cadaveric specimens to describe in detail the different attachment patterns of the alar ligaments onto the dens. METHODS: Twenty-two sides from eleven, fresh frozen, cadaveric heads were used. The specimens included eight males and three females that ranged in age from 67 to 99-years-old at death...
August 9, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28800895/a-randomized-trial-of-a-web-based-platform-to-help-families-manage-dementia-related-behavioral-symptoms-the-wecareadvisor%C3%A2
#5
Laura N Gitlin, Helen J Kales, Katherine Marx, Barbara Stanislawski, Constantine Lyketsos
Dementia-related behavioral symptoms are challenging clinical features occurring across etiologies and disease progression. They are associated with increased healthcare utilization, nursing home placement, family upset and burden. Families typically manage behavioral symptoms without requisite knowledge, skills and guidance. We designed WeCareAdvisor™ as an easy-to-use, evidence-informed web-based platform. It provides families knowledge about dementia, daily tips, and a systematic approach to describe behaviors, investigate modifiable contributors, create treatment plans (WeCareAdvisor™ Prescription) consisting of management tips tailored to symptom presentation, and evaluate effectiveness...
August 8, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28800592/cx3cr1-knockout-aggravates-coxsackievirus-b3-induced-myocarditis
#6
Irene Müller, Kathleen Pappritz, Konstantinos Savvatis, Kerstin Puhl, Fengquan Dong, Muhammad El-Shafeey, Nazha Hamdani, Isabell Hamann, Michel Noutsias, Carmen Infante-Duarte, Wolfgang A Linke, Sophie Van Linthout, Carsten Tschöpe
Studies on inflammatory disorders elucidated the pivotal role of the CX3CL1/CX3CR1 axis with respect to the pathophysiology and diseases progression. Coxsackievirus B3 (CVB3)-induced myocarditis is associated with severe cardiac inflammation, which may progress to heart failure. We therefore investigated the influence of CX3CR1 ablation in the model of acute myocarditis, which was induced by inoculation with 5x105 plaque forming units of CVB3 (Nancy strain) in either CX3CR1-/- or C57BL6/j (WT) mice. Seven days after infection, myocardial inflammation, remodeling, and titin expression and phosphorylation were examined by immunohistochemistry, real-time PCR and Pro-Q diamond stain...
2017: PloS One
https://www.readbyqxmd.com/read/28800532/cell-cycle-arrest-mediated-by-cd-induced-dna-damage-in-arabidopsis-root-tips
#7
Weina Cui, Hetong Wang, Jie Song, Xia Cao, Hilary J Rogers, Dennis Francis, Chunyun Jia, Lizong Sun, Meifang Hou, Yuesuo Yang, Peidong Tai, Wan Liu
Accumulating evidence demonstrates that the aberrant expression of cell cycle regulation and DNA repair genes can result in abnormal cell proliferation and genomic instability in eukaryotic cells under different stresses. Herein, Arabidopsis thaliana (Arabidopsis) seedlings were grown hydroponically on 0.5 × MS media containing cadmium (Cd) at 0-2.5mgL(-1) for 5d of treatment. Real time quantitative reverse transcription-polymerase chain reaction (qRT-PCR) analysis revealed that expression of DNA damage repair and cell cycle regulation genes, including BRCA1, MRE11, WEE1, CDKA;1 and PCNA1, showed an inverted U-shaped dose-response...
August 8, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28796547/do-superior-or-inferior-interlaminar-approach-or-bevel-orientation-predispose-to-nonepidural-needle-penetration
#8
Nicholas A Koontz, Richard H Wiggins, Gregory J Stoddard, Lubdha M Shah
OBJECTIVE: There is a paucity of evidence-based literature regarding the advantages and disadvantages of the interlaminar approach and needle bevel orientation for performing a lumbar interlaminar epidural steroid injection (ESI). The purpose of this study was to determine if superior versus inferior lamina approach, needle bevel tip orientation, or both may predispose to inadvertent nonepidural penetration during lumbar interlaminar ESI. SUBJECTS AND METHODS: A prospective study was performed of patients with low back pain with or without radicular pain or neurogenic claudication referred for lumbar interlaminar ESI...
August 10, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28796132/optimal-point-of-insertion-and-needle-angle-in-neuraxial-blockade-using-a-midline-approach-a-study-in-computed-tomography-scans-of-adult-patients
#9
Mark Vogt, Dennis J van Gerwen, Wouter Lubbers, John J van den Dobbelsteen, Martin Hagenaars
BACKGROUND AND OBJECTIVES: Neuraxial blockade using a midline approach can be challenging. Part of this challenge lies in finding the optimal approach of the needle to its target. The present study aimed at finding (1) the optimal point of insertion of the needle between the tips of 2 adjacent spinous processes and (2) the optimal angle relative to the skin at which the needle should approach the epidural or subarachnoid space. METHODS: A computer algorithm systematically analyzed computed tomography scans of vertebral columns of a cohort of 52 patients...
August 8, 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/28782092/hard-tissue-debris-removal-from-the-mesial-root-canal-system-of-mandibular-molars-with-ultrasonically-and-laser-activated-irrigation-a-micro-computed-tomography-study
#10
J Verstraeten, W Jacquet, R J G De Moor, M A Meire
This study is to investigate the efficacy of different irrigant activation techniques on removal of accumulated hard tissue debris (AHTD) in mesial roots of human mandibular molars. Extracted human mandibular molars with an isthmus between the mesial root canals were selected based on micro-CT (μCT) scans. The mesial canals were instrumented to an apical diameter ISO30 using ProTaper rotary files. Teeth were randomly assigned to three irrigant activation groups (n = 10): ultrasonically activated irrigation (UAI) using a size 20 Irrisafe for 3 × 20 s, laser-activated irrigation (LAI) with an Er:YAG laser (2940 nm) and plain 300 μm fiber tip inside the canal (20 mJ, 20 Hz, 3 × 20 s), and laser-activated irrigation with identical parameters with a 400 μm photon-induced photoacoustic streaming (PIPS) tip held at the canal entrance...
August 7, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28782006/nondestructive-imaging-of-atomically-thin-nanostructures-buried-in-silicon
#11
Georg Gramse, Alexander Kölker, Tingbin Lim, Taylor J Z Stock, Hari Solanki, Steven R Schofield, Enrico Brinciotti, Gabriel Aeppli, Ferry Kienberger, Neil J Curson
It is now possible to create atomically thin regions of dopant atoms in silicon patterned with lateral dimensions ranging from the atomic scale (angstroms) to micrometers. These structures are building blocks of quantum devices for physics research and they are likely also to serve as key components of devices for next-generation classical and quantum information processing. Until now, the characteristics of buried dopant nanostructures could only be inferred from destructive techniques and/or the performance of the final electronic device; this severely limits engineering and manufacture of real-world devices based on atomic-scale lithography...
June 2017: Science Advances
https://www.readbyqxmd.com/read/28781982/influence-of-cathode-geometry-on-electron-dynamics-in-an-ultrafast-electron-microscope
#12
Shaozheng Ji, Luca Piazza, Gaolong Cao, Sang Tae Park, Bryan W Reed, Daniel J Masiel, Jonas Weissenrieder
Efforts to understand matter at ever-increasing spatial and temporal resolutions have led to the development of instruments such as the ultrafast transmission electron microscope (UEM) that can capture transient processes with combined nanometer and picosecond resolutions. However, analysis by UEM is often associated with extended acquisition times, mainly due to the limitations of the electron gun. Improvements are hampered by tradeoffs in realizing combinations of the conflicting objectives for source size, emittance, and energy and temporal dispersion...
September 2017: Structural Dynamics (Melville, N.Y.)
https://www.readbyqxmd.com/read/28774707/2d-projection-based-software-application-for-mobile-c-arms-optimises-wire-placement-in-the-proximal-femur-an-experimental-study
#13
B Swartman, D Frere, W Wei, M Schnetzke, N Beisemann, H Keil, J Franke, P A Grützner, S Y Vetter
PURPOSE: A new software application can be used without fixed reference markers or a registration process in wire placement. The aim was to compare placement of Kirschner wires (K-wires) into the proximal femur with the software application versus the conventional method without guiding. As study hypothesis, we assumed less placement attempts, shorter procedure time and shorter fluoroscopy time using the software. The same precision inside a proximal femur bone model using the software application was premised...
July 25, 2017: Injury
https://www.readbyqxmd.com/read/28772008/dual-wavelength-reflectance-spectroscopy-of-the-superior-vena-cava-a-method-for-placing-central-venous-catheters-at-the-cavoatrial-junction
#14
Bradley J Stringer, Spencer B Shumway, Matthew D Holbrook, Cameron G Copeland, Alexander A Gosch, Kai Kück
There are a limited number of methods to guide and confirm the placement of a peripherally-inserted central catheter (PICC) at the cavoatrial junction. The aim of this study was to design, test, and validate a dual wavelength, diode laser-based, single optical fiber instrument that would accurately confirm PICC tip location at the cavoatrial junction of an animal heart, in vivo. This was accomplished by inserting the optical fiber into a PICC and ratiometrically comparing simultaneous visible and near-infrared reflection intensities of venous and atrial tissues found near the cavoatrial junction...
August 3, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28768818/sofia-intermediate-catheter-and-the-snake-technique-safety-and-efficacy-of-the-sofia-catheter-without-guidewire-or-microcatheter-construct
#15
Jeremy J Heit, Johnny Hy Wong, Adrienne M Mofaff, Nicholas A Telischak, Robert L Dodd, Michael P Marks, Huy M Do
BACKGROUND: Neurointerventional surgeries (NIS) benefit from supportive endovascular constructs. Sofia is a soft-tipped, flexible, braided single lumen intermediate catheter designed for NIS. Sofia advancement from the cervical to the intracranial circulation without a luminal guidewire or microcatheter construct has not been described. OBJECTIVE: To evaluate the efficacy and safety of the new Sofia Non-wire Advancement techniKE (SNAKE) for advancement of the Sofia into the cerebral circulation...
August 2, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/28767217/synthesis-and-physical-properties-of-phase-engineered-transition-metal-dichalcogenide-monolayer-heterostructures
#16
Carl H Naylor, William M Parkin, Zhaoli Gao, Joel Berry, Songsong Zhou, Qicheng Zhang, John Brandon McClimon, Liang Z Tan, Christopher E Kehayias, Meng-Qiang Zhao, Ram S Gona, Robert W Carpick, Andrew M Rappe, David J Srolovitz, Marija Drndic, Alan T Charlie Johnson
Heterostructures of transition metal dichalcogenides (TMDs) offer the attractive prospect of combining distinct physical properties derived from different TMD structures. Here we report direct chemical vapor deposition of in-plane monolayer heterostructures based on 1H-MoS2 and 1T'-MoTe2. The large lattice mismatch between these materials led to intriguing phenomena at their interface. Atomic force microscopy indicated buckling in the 1H region. Tip-enhanced Raman spectroscopy showed mode structure consistent with Te substitution in the 1H region during 1T'-MoTe2 growth...
August 2, 2017: ACS Nano
https://www.readbyqxmd.com/read/28764254/role-of-provisional-fixation-of-fracture-fragments-by-steinmann-pin-and-technical-tips-in-proximal-femoral-nailing-for-intertrochanteric-fracture
#17
Mohit J Jain, Kinjal J Mavani, Dhaval Patel
INTRODUCTION: Proximal Femoral Nailing (PFN) in Intertrochanteric Fractures (IF) is becoming the choice of implant due to better biomechanics and prevention of varus collapse associated with Dynamic Hip Screw (DHS). Technical difficulties and implant related complications are yet to be addressed. AIM: To understand the technical difficulties involved in PFN and role of provisional fixation of fracture by Steinmann-pin. MATERIALS AND METHODS: In this study, 55 patients presented to a tertiary trauma center in India with trochanteric fractures from April 2010 to March 2012 were included and treated with PFN...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28762464/the-mid-point-transverse-process-to-pleura-mtp-block-a-new-end-point-for-thoracic-paravertebral-block
#18
I Costache, L de Neumann, C J Ramnanan, S L Goodwin, A Pawa, F W Abdallah, C J L McCartney
Current descriptions of thoracic paravertebral block techniques require the needle tip to be anterior to the superior costotransverse ligament. We hypothesised that an injection point midway between the posterior border of the transverse process and the pleura would result in spread to the paravertebral space. We completed bilateral injections of 5 ml methylene blue 0.2% midway between the posterior border of the transverse process and the pleura at T2, T4, T6, T8 and T10 in three unembalmed cadavers. The presence of methylene blue dye at the nerve root in the paravertebral space, the corresponding intercostal nerve and sympathetic chain at the level of injection, and at additional levels, was examined...
August 1, 2017: Anaesthesia
https://www.readbyqxmd.com/read/28762253/intraocular-robotic-interventional-surgical-system-iriss-mechanical-design-evaluation-and-master-slave-manipulation
#19
Jason T Wilson, Matthew J Gerber, Stephen W Prince, Cheng-Wei Chen, Steven D Schwartz, Jean-Pierre Hubschman, Tsu-Chin Tsao
BACKGROUND: Since the advent of robotic-assisted surgery, the value of using robotic systems to assist in surgical procedures has been repeatedly demonstrated. However, existing technologies are unable to perform complete, multi-step procedures from start to finish. Many intraocular surgical steps continue to be manually performed. METHODS: An intraocular robotic interventional surgical system (IRISS) capable of performing various intraocular surgical procedures was designed, fabricated, and evaluated...
July 31, 2017: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
https://www.readbyqxmd.com/read/28762232/morphofunctional-basis-of-the-different-types-of-angiogenesis-and-formation-of-postnatal-angiogenesis-related-secondary-structures
#20
REVIEW
L Díaz-Flores, R Gutiérrez, M P García-Suárez, F J Sáez, E Gutiérrez, F Valladares, J L Carrasco, L Díaz-Flores, J F Madrid
We review the morpho-functional basis of the different types of angiogenesis and report our observations, including the formation of angiogenesis-related secondary structures. First of all, we consider the following issues: a) conceptual differences between angiogenesis and vasculogenesis, b) incidence of angiogenesis in pre- and postnatal life, c) regions of vascular tree with angiogenic capacity, d) cells (endothelial cells, pericytes, CD34+ adventitial stromal cells of the microvasculature and inflammatory cells) and extracellular matrix components involved in angiogenesis, e) events associated with angiogenesis, f) different types of angiogenesis, including sprouting and intussusceptive angiogenesis, and other angiogenic or vascularization forms arising from endothelial precursor cells (postnatal vasculogenesis), vasculogenesis mimicry, vessel co-option and piecemeal angiogenesis...
August 1, 2017: Histology and Histopathology
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