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https://www.readbyqxmd.com/read/29777548/higher-contact-force-during-radiofrequency-ablation-leads-to-a-much-larger-increase-in-edema-as-compared-to-chronic-lesion-size
#1
Samuel Thomas, Josh Silvernagel, Nathan Angel, Eugene Kholmovski, Elyar Ghafoori, Nan Hu, John Ashton, Derek J Dosdall, Rob MacLeod, Ravi Ranjan
INTRODUCTION: Reversible edema is a part of any radiofrequency ablation but its relationship with contact force is unknown. The goal of this study was to characterize through histology and MRI, acute and chronic ablation lesions and reversible edema with contact force. METHODS AND RESULTS: In a canine model (n = 14), chronic ventricular lesions were created with a 3.5 mm tip ThermoCool SmartTouch (Biosense Webster) catheter at 25W or 40W for 30 sec. Repeat ablation was performed after 3 months to create a second set of lesions (acute)...
May 18, 2018: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29774907/plasmon-response-evaluation-based-on-image-derived-arbitrary-nanostructures
#2
S Trautmann, M Richard-Lacroix, A Dathe, H Schneidewind, J Dellith, W Fritzsche, V Deckert
The optical response of realistic 3D plasmonic substrates composed of randomly shaped particles of different size and interparticle distance distributions in addition to nanometer scale surface roughness is intrinsically challenging to simulate due to computational limitations. Here, we present a Finite Element Method (FEM)-based methodology that bridges in-depth theoretical investigations and experimental optical response of plasmonic substrates composed of such silver nanoparticles. Parametrized scanning electron microscopy (SEM) images of surface enhanced Raman spectroscopy (SERS) active substrate and tip-enhanced Raman spectroscopy (TERS) probes are used to simulate the far-and near-field optical response...
May 18, 2018: Nanoscale
https://www.readbyqxmd.com/read/29774532/the-fetus-at-the-tipping-point-modifying-the-outcome-of-fetal-asphyxia
#3
Simerdeep K Dhillon, Christopher A Lear, Robert Galinsky, Guido Wassink, Joanne O Davidson, Sandra Juul, Nicola J Robertson, Alistair J Gunn, Laura Bennet
Brain injury around birth is associated with nearly half of all cases of cerebral palsy. Although brain injury is multifactorial, particularly after preterm birth, acute hypoxia-ischaemia is a major contributor to injury. It is now well established that the severity of injury after HI is determined by a dynamic balance between injurious and protective processes. In addition, mothers who are at risk of premature delivery have high rates of diabetes and antepartum infection/inflammation and are almost universally given treatments such as antenatal glucocorticoids and magnesium sulphate to reduce the risk of death and complications after preterm birth...
May 17, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29773457/effect-of-increasing-flow-when-grooving-during-phacoemulsification
#4
Brian A Bird, Rhett S Thomson, Lance A Stutz, Joshua B Heczko, Ashlie A Bernhisel, William R Barlow, Brian Zaugg, Jeff H Pettey, Randall J Olson
PURPOSE: To determine optimum flow settings on the Centurion Vision System during the grooving step in cataract surgery. SETTING: John A. Moran Eye Center Laboratory, University of Utah, Salt Lake City, Utah, USA. DESIGN: Experimental study. METHODS: Intact porcine lenses hardened by formalin and placed in a chamber designed to simulate the anterior chamber of the eye were used to test flow rate settings at 20 mL/min, 40 mL/min, and 60 mL/min...
May 15, 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29771774/bronchoscopic-laser-interstitial-thermal-therapy-an-experimental-study-in-normal-porcine-lung-parenchyma
#5
Roberto F Casal, Garrett Walsh, Mark McArthur, Lori R Hill, Maria F Landaeta, Aristides J Armas Villalba, Philip Ong, Labib Debiane, Erik Vakil, Horiana B Grosu, Carlos A Jimenez, David Ost, Roberto Adachi, George A Eapen
BACKGROUND: Population aging and lung cancer screening strategies may lead to an increase in detection of early-stage lung cancer in medical inoperable patients. Recent advances in peripheral bronchoscopy have made it a suitable platform for ablation of small peripheral tumors. METHODS: We investigated the tissue-ablative effect of a diode laser bronchoscopically applied by a laser delivery fiber (LDF) with wide aperture on porcine lung parenchyma. Laser was tested ex vivo and in vivo to identify the most effective power settings and LDF...
May 16, 2018: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/29771187/advanced-stage-breast-cancer-is-associated-with-catheter-tip-thrombus-formation-following-implantable-central-venous-port-placement
#6
Mina S Makary, Alexander Lionberg, Mamdouh Khayat, Maryam B Lustberg, Jamal AlTaani, Xueliang J Pan, Richard R Layman, Subha V Raman, Rachel M Layman, Joshua D Dowell
Purpose Catheter-tip associated thrombosis is not uncommon in patients with implantable central venous ports; however, the prevalence and clinical impact of this complication on patient management is unclear. This study aims to identify risk factors for thrombus formation in a large population receiving serial echocardiograms (echo) following port placement. Methods A total of 396 female breast cancer patients underwent internal jugular vein chest port placement between 2007 and 2013 and received echo studies every third month...
January 1, 2018: Phlebology
https://www.readbyqxmd.com/read/29770873/xiphoidectomy-for-intractable-xiphodynia
#7
Patrick Dorn, Michael A Kuhn, Barbara A Schweizer, Ralph A Schmid, Gregor J Kocher
BACKGROUND: Xiphodynia is a rare condition with hardly any data published regarding xiphoidectomy as a valid treatment option for intractable disease. It is necessary to bear this syndrome in mind after having filtered out other differential diagnoses. METHODS: Between 2003 and 2015, 11 patients underwent xiphoidectomy for intractable xiphodynia at our institution. Patients' charts were reviewed including preoperative workup, operative technique, and results. Every patient had routine follow-ups, 4 weeks after the procedure and 1 year after surgery...
May 16, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29770770/adjustable-diameter-tips-in-the-pediatric-patient-the-constrained-technique
#8
Brandon C Perry, Eric J Monroe, Giridhar Shivaram
Placement of transjugular intrahepatic portosystemic shunt (TIPS) is necessary in children with portal hypertension complicated by variceal bleeding or ascites. However, placement of adult-sized endografts may be problematic due to the smaller anatomy of pediatric patients. On the other hand, placement of fixed diameter smaller stents have the corresponding problem of not accommodating future growth of the child. We describe a novel method to create an adjustable diameter TIPS as a technical solution to these problems...
May 2018: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/29769687/health-tips-for-research-groups
#9
David Norris, Ulrich Dirnagl, Michael J Zigmond, Katherine Thompson-Peer, Tracy T Chow
No abstract text is available yet for this article.
May 2018: Nature
https://www.readbyqxmd.com/read/29769487/length-of-vermiform-appendix-in-bangladeshi-people-of-different-age-and-sex
#10
S A Sumi, M Khalil, S Mannan, S Chowdhury, M K Khan, U K Paul, U K Zaman, S F Karim, A Rahman, M M Rahman, A Kabir, S Farjan, M T Alam, E Z Epsi, N S Nitu, N J Khan, L Jabeen, S Tabriz
A cross sectional descriptive study was performed on 70 postmortem vermiform appendix (male 34 and female 36) to find out the length of vermiform appendix of Bangladeshi people in different age and sex. The specimens were collected from autopsy laboratory of the Department of Forensic Medicine, Mymensingh Medical College, Mymensingh, Bangladesh from October 2016 to March 2017 by purposive sampling technique. The collected samples were divided into four age groups. They were Group A (upto 20 years), Group B (21 to 40 years), Group C (41 to 60 years) and Group D (above 60 years)...
April 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29769168/pressure-wire-compared-to-microcatheter-sensing-for-coronary-fractional-flow-reserve-the-perform-study
#11
Ziad A Ali, Yasir Parviz, Matthew Brinkman, Mitsuaki Matsumura, Björn Redfors, David A Brogno, Maria D Corral, Khady N Fall, Gary S Mintz, Gregg W Stone, Akiko Maehara, Allen Jeremias, Ajay J Kirtane
AIMS: Among technologies used to assess FFR, a monorail, sensor-tipped micro pressure catheter (PC) may be advantageous for delivery and re-assessment. We sought to determine whether the larger cross-sectional area of the PC influences FFR measurements compared to the pressure wire. METHODS AND RESULTS: PERFORM was a single-center, prospective study designed to determine the precision and accuracy of the PC compared with the pressure wire (PW) for measurement of FFR...
May 15, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29759489/ablation-index-and-surround-flow-catheter-irrigation-impedance-based-appraisal-in-clinical-ablation
#12
Waqas Ullah, Ross J Hunter, Malcolm C Finlay, Ailsa McLean, Mehul B Dhinoja, Simon Sporton, Mark J Earley, Richard J Schilling
OBJECTIVES: This study sought to assess the impact of ablation power and catheter irrigation during clinical radiofrequency ablation using impedance drop. BACKGROUND: In preclinical studies, ablation power and catheter irrigation are determinants of ablation efficacy. METHODS: Static 30-s left atrial ablations were delivered in patients undergoing their first atrial fibrillation ablation. Impedance drop during ablation (as a measure of efficacy) was compared using the following: the force time integral (FTI); the FTI-P (a cumulative multiple FTI and ablation power), and ablation index (AI), a weighted algorithm including contact force, power, and duration...
October 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29757925/a-modified-co2-o2-guedel-airway-improves-capnographic-accuracy-compared-with-a-co2-o2-nasal-cannula-an-infant-manikin-study
#13
Jens Moll, Pinelopi Anagnostopoulou, Franz J Frei, Thomas O Erb
BACKGROUND: Capnography via a CO2/O2 nasal cannula is commonly used for respiratory monitoring during sedation. However, signal disturbances are frequently encountered, especially in young children. OBJECTIVE: Sampling ports placed closer to the trachea have been shown to result in improved signal quality. In a manikin model of a 6-month-old infant we compared capnography from a modified Guedel airway with a CO2 port located at the tip with that from a CO2/O2 nasal cannula...
April 30, 2018: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/29757161/fast-and-straightforward-analysis-approach-of-charge-transport-data-in-single-molecule-junctions
#14
Qian Zhang, Chenguang Liu, Shuhui Tao, Ruowei Yi, Weitao Su, Ce Zhou Zhao, Chun Zhao, Yannick J Dappe, Richard J Nichols, Li Yang
In this study, we introduce an efficient data sorting algorithm, including filters for noisy signals, conductance mapping for analyzing the most dominant conductance group and sub-population groups. The capacity of our data analysis process has also been corroborated on real experimental data sets. Over 11,000 I(s) traces, representing the current (I) versus STM tip retraction distance (s) signals of Au-1,6-hexanedithiol-Au and Au-1,8-octanedithiol-Au molecular junctions have been collected. The fully automated and unsupervised program requires less than one minute on a standard PC to achieve sort the data and generate histograms...
May 14, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29756168/transsplenic-splenoportography-and-portal-venous-interventions-in-pediatric-patients
#15
Eric J Monroe, Ethan J Speir, C Matthew Hawkins, Giri Shivaram, Kevin S H Koo, Anne E Gill
BACKGROUND: Data regarding transsplenic portal venous access for diagnostic imaging and endovascular intervention in children are limited, possibly due to concerns regarding high bleeding risks and resultant underutilization. OBJECTIVE: To investigate the safety and utility of transsplenic splenoportography and portal venous interventions in children. MATERIALS AND METHODS: A retrospective review was performed of all pediatric patients undergoing percutaneous transsplenic portal venous access and intervention at two large tertiary pediatric institutions between January 2012 and April 2017 was performed...
May 13, 2018: Pediatric Radiology
https://www.readbyqxmd.com/read/29753476/technical-note-the-development-of-a-methodology-for-ruminal-and-colon-tissue-biopsying-of-young-holstein-dairy-calves
#16
J K van Niekerk, M Middeldorp, M A Steele
The objectives of this study were to develop a methodology for biopsying the rumen and colon of young dairy calves and to collect suitable quality tissue samples for microscopic and gene expression analysis. Six Holstein dairy bull calves (45.0 ± 1.5 kg birth weight) were ruminally cannulated during the second week of life and weaned at the end of wk 6. Ruminal and colon tissue samples were collected at the end of wk 5, 6, 7, 8, and 12. Calves were not sedated but were restrained in a chute for sampling. The endoscope (100 cm length, 9...
May 9, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29753267/the-localisation-of-the-heparin-binding-sites-of-human-and-murine-interleukin-12-within-the-carboxyterminal-domain-of-the-p40-subunit
#17
Pascale Garnier, Rosemary Mummery, Mark J Forster, Barbara Mulloy, Roslyn V Gibbs, Christopher C Rider
We have previously shown that the heterodimeric cytokine interleukin-12, and the homodimer of its larger subunit p40, both bind to heparin and heparan sulfate with relatively high affinity. In the present study we characterised these interactions using a series of chemically modified heparins as competitive inhibitors. Human interleukin-12 and p40 homodimer show indistinguishable binding profiles with a panel of heparin derivatives, but that of murine interleukin-12 is distinct. Heparin markedly protects the human and murine p40 subunits, but not the p35 subunits, from cleavage by the bacterial endoprotease LysC, further implicating the larger subunit as the location of the heparin binding site...
May 9, 2018: Cytokine
https://www.readbyqxmd.com/read/29752201/maxillary-tooth-growth-in-the-adult-male-babirusa-genus-babyrousa
#18
Alastair A Macdonald, Darren J Shaw
The growth of the maxillary canine teeth of the babirusa (genus Babyrousa) was studied on a sample of 149 adult male babirusa skulls from twenty-two international museum and private collections. Skulls from Buru, Sulawesi and the Togian Islands were represented. The continuous growth process was summarised into five stages ('A'-'E') according to the position of the tip of the tooth over the bones of the skull. The supracutaneous portion of the tooth grew in a curve-linear fashion dorso-caudally, and was orientated such that the tips grew towards the midline of the cranium...
May 8, 2018: Comptes Rendus Biologies
https://www.readbyqxmd.com/read/29750695/proximal-versus-distal-continuous-adductor-canal-blocks-does-varying-perineural-catheter-location-influence-analgesia-a-randomized-subject-masked-controlled-clinical-trial
#19
Jacklynn F Sztain, Bahareh Khatibi, Amanda M Monahan, Engy T Said, Wendy B Abramson, Rodney A Gabriel, John J Finneran, Richard H Bellars, Patrick L Nguyen, Scott T Ball, Francis B Gonzales, Sonya S Ahmed, Michael C Donohue, Jennifer A Padwal, Brian M Ilfeld
BACKGROUND: A continuous adductor canal block provides analgesia after surgical procedures of the knee. Recent neuroanatomic descriptions of the thigh and knee led us to speculate that local anesthetic deposited in the distal thigh close to the adductor hiatus would provide superior analgesia compared to a more proximal catheter location. We therefore tested the hypothesis that during a continuous adductor canal nerve block, postoperative analgesia would be improved by placing the perineural catheter tip 2-3 cm cephalad to where the femoral artery descends posteriorly to the adductor hiatus (distal location) compared to a more proximal location at the midpoint between the anterior superior iliac spine and the superior border of the patella (proximal location)...
May 9, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29748758/how-to-accurately-predict-solution-phase-gold-nanostar-stability
#20
Wenjing Xi, Hoa T Phan, Amanda J Haes
Unwanted nanoparticle aggregation and/or agglomeration may occur when anisotropic nanoparticles are dispersed in various solvents and matrices. While extended Derjaguin-Landau-Verwey-Overbeek (DLVO) theory has been successfully applied to predict nanoparticle stability in solution, this model fails to accurately predict the physical stability of anisotropic nanostructures; thus limiting its applicability in practice. Herein, DLVO theory was used to accurately predict gold nanostar stability in solution by investigating how the choice of the nanostar dimension considered in calculations influences the calculated attractive and repulsive interactions between nanostructures...
May 11, 2018: Analytical and Bioanalytical Chemistry
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