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https://www.readbyqxmd.com/read/29331948/lvis-blue-as-a-low-porosity-stent-and-coil-adjuvant
#1
Matthew J Koch, Christopher J Stapleton, Scott B Raymond, Susan Williams, Thabele M Leslie-Mazwi, James David Rabinov, Aman B Patel
INTRODUCTION: The LVIS Blue is an FDA-approved stent with 28% metallic coverage that is indicated for use in conjunction with coil embolization for the treatment of intracranial aneurysms. Given a porosity similar to approved flow diverters and higher than currently available intracranial stents, we sought to evaluate the effectiveness of this device for the treatment of intracranial aneurysms. METHODS: We performed an observational single-center study to evaluate initial occlusion and occlusion at 6-month follow-up for patients treated with the LVIS Blue in conjunction with coil embolization at our institution using the modified Raymond-Roy classification (mRRC), where mRRC 1 indicates complete embolization, mRRC 2 persistent opacification of the aneurysm neck, mRRC 3a filling of the aneurysm dome within coil interstices, and mRRC 3b filling of the aneurysm dome...
January 13, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29330360/fibre-optic-metadevice-for-all-optical-signal-modulation-based-on-coherent-absorption
#2
Angelos Xomalis, Iosif Demirtzioglou, Eric Plum, Yongmin Jung, Venkatram Nalla, Cosimo Lacava, Kevin F MacDonald, Periklis Petropoulos, David J Richardson, Nikolay I Zheludev
Recently, coherent control of the optical response of thin films in standing waves has attracted considerable attention, ranging from applications in excitation-selective spectroscopy and nonlinear optics to all-optical image processing. Here, we show that integration of metamaterial and optical fibre technologies allows the use of coherently controlled absorption in a fully fiberized and packaged switching metadevice. With this metadevice, which controls light with light in a nanoscale plasmonic metamaterial film on an optical fibre tip, we provide proof-of-principle demonstrations of logical functions XOR, NOT and AND that are performed within a coherent fibre network at wavelengths between 1530 and 1565 nm...
January 12, 2018: Nature Communications
https://www.readbyqxmd.com/read/29326158/reciprocal-spatiotemporally-controlled-apoptosis-regulates-wolffian-duct-cloaca-fusion
#3
Masato Hoshi, Antoine Reginensi, Matthew S Joens, James A J Fitzpatrick, Helen McNeill, Sanjay Jain
The epithelial Wolffian duct (WD) inserts into the cloaca (primitive bladder) before metanephric kidney development, thereby establishing the initial plumbing for eventual joining of the ureters and bladder. Defects in this process cause common anomalies in the spectrum of congenital anomalies of the kidney and urinary tract (CAKUT). However, developmental, cellular, and molecular mechanisms of WD-cloaca fusion are poorly understood. Through systematic analysis of early WD tip development in mice, we discovered that a novel process of spatiotemporally regulated apoptosis in WD and cloaca was necessary for WD-cloaca fusion...
January 11, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29324592/frequent-subclinical-macular-changes-in-combined-braf-mek-inhibition-with-high-dose-hydroxychloroquine-as-treatment-for-advanced-metastatic-braf-mutant-melanoma-preliminary-results-from-a-phase-i-ii-clinical-treatment-trial
#4
Akosua A Nti, Leona W Serrano, Harpal S Sandhu, Katherine E Uyhazi, Ilaina D Edelstein, Elaine J Zhou, Scott Bowman, Delu Song, Tara C Gangadhar, Lynn M Schuchter, Sheryl Mitnick, Alexander Huang, Charles W Nichols, Ravi K Amaravadi, Benjamin J Kim, Tomas S Aleman
PURPOSE: To assess the potential ocular toxicity of a combined BRAF inhibition (BRAFi) + MEK inhibition (MEKi) + hydroxychloroquine (HCQ) regime used to treat metastatic BRAF mutant melanoma. METHODS: Patients with stage IV metastatic melanoma and BRAF V600E mutations (n = 11, 31-68 years of age) were included. Treatment was with oral dabrafenib, 150 mg bid, trametinib, 2 mg/day, and HCQ, 400 mg to 600 mg bid. An ophthalmic examination, spectral domain optical coherence tomography, near-infrared and short-wavelength fundus autofluorescence, and static perimetry were performed at baseline, 1 month, and q/6 months after treatment...
January 10, 2018: Retina
https://www.readbyqxmd.com/read/29323388/a-novel-thermal-detection-method-based-on-molecularly-imprinted-nanoparticles-as-recognition-elements
#5
Francesco Canfarotta, J Czulak, K Betlem, A Sachdeva, K Eersels, B van Grinsven, T J Cleij, M Peeters
Molecularly Imprinted Polymers (MIPs) are synthetic receptors that are able to selectively bind their target molecule and, for this reason, they are currently employed as recognition elements in sensors. In this work, MIP nanoparticles (nanoMIPs) are produced by solid-phase synthesis for a range of templates with different sizes, including a small molecule (biotin), two peptides (one derived from the epithelial growth factor receptor and vancomycin) and a protein (trypsin). NanoMIPs are then dipcoated on the surface of thermocouples that measure the temperature inside a liquid flow cell...
January 11, 2018: Nanoscale
https://www.readbyqxmd.com/read/29320583/a-multi-center-open-label-prospective-study-of-cannula-injection-of-small-particle-hyaluronic-acid-plus-lidocaine-sphal-for-lip-augmentation
#6
Raj Chopra, Miles Graivier, Sabrina Fabi, Mark Nestor, Patricia Meuse, Jay Mashburn
<p>BACKGROUND: The use of blunt-tipped microcannulas for injection of hyaluronic acid (HA) filler in the lip and perioral area has gained popularity as they provide important safety-related advantages compared to traditional hypodermic needles. This study was conducted to assess the safety and effectiveness associated with the use of a blunt-tipped microcannula for lip augmentation and correction of perioral rhytids using a small-particle, hyaluronic acid gel plus lidocaine (SPHAL).</p> <p>METHODS: A multi-center, open-label, prospective, study enrolled 60 subjects...
January 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29315180/an-in-vitro-insertion-force-study-of-magnetically-guided-lateral-wall-cochlear-implant-electrode-arrays
#7
Lisandro Leon, Frank M Warren, Jake J Abbott
HYPOTHESIS: Insertion forces can be reduced by magnetically guiding the tip of lateral-wall cochlear-implant electrode arrays during insertion via both cochleostomy and the round window. BACKGROUND: Steerable electrode arrays have the potential to minimize intracochlear trauma by reducing the severity of contact between the electrode-array tip and the cochlear wall. However, steerable electrode arrays typically have increased stiffness associated with the steering mechanism...
February 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29314623/mapping-perfluoroalkyl-effects-in-togni-type-reagents-by-thermolysis
#8
Nico Santschi, Dmitry Katayev, Roxan Calvo, Benson J Jelier
We present the thermolysis of cyclic hypervalent iodine(III) perfluoroalkyl transfer reagents carried out in standard GC-MS instrumentation. Through heating, these structures undergo fragmentation to afford perfluoroalkyl radicals F2n+1Cn* and each reagent can be characterized by means of a threshold temperature, TIP(n). This parameter TIP(n) not only reflects the stability of the F2n+1Cn-I bond, but potentially also carries information regarding fundamental properties of the linear perfluoroalkyl chains.
January 3, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/29311233/characterization-and-protective-efficacy-of-type-three-secretion-proteins-as-a-broadly-protective-subunit-vaccine-against-salmonella-enterica-serovars
#9
Francisco J Martinez-Becerra, Prashant Kumar, Vikalp Vishwakarma, Jae Hyun Kim, Olivia Arizmendi, C Russell Middaugh, William D Picking, Wendy L Picking
Non-typhoidal Salmonella enterica serotypes (NTS) are the leading cause of hospitalization and death due to foodborne illnesses. NTS are the costliest of the foodborne pathogens and cause ∼$4 billion annually in healthcare costs. In Africa, new invasive NTS are the leading cause of bacteremia especially in HIV-positive children and adults. Current vaccines against S. enterica are not broadly protective and most are directed at the typhoid causing serotypes, not the NTS. All S. enterica require two type III secretion systems (T3SS) for virulence...
January 8, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29311205/thermoelectric-magnetohydrodynamic-effects-on-the-crystal-growth-rate-of-undercooled-ni-dendrites
#10
A Kao, J Gao, K Pericleous
In the undercooled solidification of pure metals, the dendrite tip velocity has been shown experimentally to have a strong dependence on the intensity of an external magnetic field, exhibiting several maxima and minima. In the experiments conducted in China, the undercooled solidification dynamics of pure Ni was studied using the glass fluxing method. Visual recordings of the progress of solidification are compared at different static fields up to 6 T. The introduction of microscopic convective transport through thermoelectric magnetohydrodynamics is a promising explanation for the observed changes of tip velocities...
February 28, 2018: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/29306411/evaluating-solid-phase-micro-extraction-tools-to-analyze-freely-ionizable-and-permanently-charged-cationic-surfactants
#11
Niels Timmer, Peter Scherpenisse, Joop L M Hermens, Steven T J Droge
Working with and analysis of cationic surfactants can be problematic since aqueous concentrations are difficult to control, both when taking environmental aqueous samples as well as performing laboratory work with spiked concentrations. For a selection of 32 amine based cationic surfactants (including C8- to C18-alkylamines, C14-dialkyldimethylammonium, C8-tetraalkylammonium, benzalkonium and pyridinium compounds), the extraction from aqueous samples was studied in detail. Aqueous concentrations were determined using solid phase extraction (SPE; 3 mL/60 mg Oasis WCX-SPE cartridges) with recoveries of ≥80% for 30 compounds, and ≥90% for 16 compounds...
March 9, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29305735/anglenav-mems-tracker-to-facilitate-ct-guided-puncture
#12
Rui Li, Sheng Xu, William F Pritchard, John W Karanian, Venkatesh P Krishnasamy, Bradford J Wood, Zion Tsz Ho Tse
As a low-cost needle navigation system, AngleNav may be used to improve the accuracy, speed, and ease of CT-guided needle punctures. The AngleNav hardware includes a wireless device with a microelectromechanical (MEMS) tracker that can be attached to any standard needle. The physician defines the target, desired needle path and skin entry point on a CT slice image. The accuracy of AngleNav was first tested in a 3D-printed calibration platform in a benchtop setting. An abdominal phantom study was then performed in a CT scanner to validate the accuracy of the device's angular measurement...
January 5, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29303594/modular-synthesis-of-rigid-polyacene-dimers-for-singlet-fission
#13
Thomas J Carey, Ethan G Miller, Alexander T Gilligan, Tarek Sammakia, Niels H Damrauer
An improved, modular synthesis of rigid, geometrically well-defined, alkyne-substituted tetracene (1) and pentacene (2) dimers is reported. The synthesis is rooted in sequential Diels-Alder reactions of a norbornyl tetraene with triisopropylsilylacetylene-substituted (TIPS-acetylene) quinone dienophiles. The incorporation of solubilizing and stabilizing TIPS-acetylene groups early in the synthesis affords a mild and reliable route, providing access, for the first time, to norbornyl-bridged pentacene dimers...
January 5, 2018: Organic Letters
https://www.readbyqxmd.com/read/29303151/swept-source-and-optical-coherence-tomography-angiography-in-patients-with-x-linked-retinoschisis
#14
N Padrón-Pérez, J Català-Mora, J Díaz, L Arias, J Prat, J M Caminal
PurposeTo explore the structural features of juvenile X-linked retinoschisis (XLRS) using swept-source-optical coherence tomography (SS-OCT) and optical coherence tomography angiography (OCT-A).DesignRetrospective, observational cross-sectional study.Patients and methodsNine patients (18 eyes) diagnosed with juvenile XLRS were included. SS-OCT and OCT-A were used to evaluate the characteristics of the inner/outer retina and the choroid.ResultsSS-OCT showed that the inner nuclear layer (INL) was the most commonly affected area (16/18 eyes; 89%)...
January 5, 2018: Eye
https://www.readbyqxmd.com/read/29290078/is-300-seconds-act-safe-and-efficient-during-miecc-procedures
#15
Adrian Bauer, Harald Hausmann, Jan Schaarschmidt, Michal Szlapka, Martin Scharpenberg, Thomas Eberle, J Michael Hasenkam
INTRODUCTION:  The recommended minimum activated clotting time (ACT) level for cardiopulmonary bypass (CPB) of 480 seconds originated from investigations with bubble oxygenators and uncoated extracorporeal circulation (ECC) systems. Modern minimal invasive ECC (MiECC) systems are completely closed circuits containing a membrane oxygenator and a tip-to-tip surface coating. We hypothesized that surface coating and the "closed-loop" design allow the MiECC to safely run with lower ACT levels and that an ACT level of 300 seconds can be safely applied without thromboembolic complications...
December 31, 2017: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/29289235/a-platform-for-time-resolved-scanning-kerr-microscopy-in-the-near-field
#16
Paul S Keatley, Thomas H J Loughran, Euan Hendry, William L Barnes, Robert J Hicken, Jeffrey R Childress, Jordan A Katine
Time-resolved scanning Kerr microscopy (TRSKM) is a powerful technique for the investigation of picosecond magnetization dynamics at sub-micron length scales by means of the magneto-optical Kerr effect (MOKE). The spatial resolution of conventional (focused) Kerr microscopy using a microscope objective lens is determined by the optical diffraction limit so that the nanoscale character of the magnetization dynamics is lost. Here we present a platform to overcome this limitation by means of a near-field TRSKM that incorporates an atomic force microscope (AFM) with optical access to a metallic AFM probe with a nanoscale aperture at its tip...
December 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/29286811/engineering-the-eigenstates-of-coupled-spin-1-2-atoms-on-a-surface
#17
Kai Yang, Yujeong Bae, William Paul, Fabian D Natterer, Philip Willke, Jose L Lado, Alejandro Ferrón, Taeyoung Choi, Joaquín Fernández-Rossier, Andreas J Heinrich, Christopher P Lutz
Quantum spin networks having engineered geometries and interactions are eagerly pursued for quantum simulation and access to emergent quantum phenomena such as spin liquids. Spin-1/2 centers are particularly desirable, because they readily manifest coherent quantum fluctuations. Here we introduce a controllable spin-1/2 architecture consisting of titanium atoms on a magnesium oxide surface. We tailor the spin interactions by atomic-precision positioning using a scanning tunneling microscope (STM) and subsequently perform electron spin resonance on individual atoms to drive transitions into and out of quantum eigenstates of the coupled-spin system...
December 1, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29280883/evidence-based-medicine-current-practices-in-rhinoplasty
#18
REVIEW
Neil Tanna, Khang T Nguyen, Ashkan Ghavami, Jay W Calvert, Bahman Guyuron, Rod J Rohrich, Ronald P Gruber
LEARNING OBJECTIVES: After studying this article, the participant should be able to: 1. Perform aesthetic and functional nasal analysis to guide septorhinoplasty. 2. Recognize common complications associated with rhinoplasty. 3. Select appropriate septorhinoplasty techniques to refine nasal aesthetics and treat nasal airway obstruction. 4. Identify factors leading to poor patient satisfaction following rhinoplasty. SUMMARY: Septorhinoplasty is among the most technically challenging procedures in the realm of plastic and reconstructive surgery...
January 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29279359/infographic-7-tips-for-developing-and-maintaining-a-high-performance-sports-medicine-team
#19
Tim J Gabbett, Simon Kearney, Leslie J Bisson, Joe Collins, Robby Sikka, Nathan Winder, Craig Sedgwick, Ed Hollis, Jeremy M Bettle
No abstract text is available yet for this article.
December 26, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29276975/non-tip-auditory-nerve-responses-that-are-suppressed-by-low-frequency-bias-tones-originate-from-reticular-lamina-motion
#20
Hui Nam, John J Guinan
Recent cochlear mechanical measurements show that active processes increase the motion response of the reticular lamina (RL) at frequencies more than an octave below the local characteristic frequency (CF) for CFs above 5 kHz. A possible correlate is that in high-CF (>5 kHz) auditory-nerve (AN) fibers, responses to frequencies 1-3 octaves below CF ("tail" frequencies) can be inhibited by medial olivocochlear (MOC) efferents. These results indicate that active processes enhance the sensitivity of tail-frequency RL and AN responses...
December 14, 2017: Hearing Research
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