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https://www.readbyqxmd.com/read/28651410/-application-of-tipping-point-analysis-to-address-missing-data-in-clinical-studies
#1
S J Zhang, Y Wang, W Li
To use a visualized method, tipping-point analysis to address missing data in clinical study and discuss related problems. All the possible outcomes caused by missing data were listed and the tipping points where P-values of hypothesis test changed at 0.05 significant level were found out, then the ratio of P<0.05 was calculated, reflecting the reliability of the study's result. Tipping-point analysis can be applied to both continuous and binary data to help find points where p-values are changed. The area of P<0...
May 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28648328/functional-outcomes-of-thumb-trapeziometacarpal-arthrodesis-with-a-locked-plate-versus-ligament-reconstruction-and-tendon-interposition
#2
K J Hippensteel, Ryan Calfee, Agnes Z Dardas, Richard Gelberman, Daniel Osei, Lindley Wall
PURPOSE: To compare standardized functional and patient-reported early outcomes following trapeziometacarpal arthrodesis (TMA) using a locking cage plate construct with trapezial excision, ligament reconstruction, and tendon interposition (LRTI). METHODS: This prospective cohort enrolled 50 consecutive patients with trapeziometacarpal osteoarthritis undergoing TMA or LRTI. Demographic data, objective measurements, Sollerman function testing, and patient-reported outcomes were collected before surgery and at various time intervals up to 12 months after surgery...
June 22, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28647634/more-successful-results-with-less-energy-in-endovenous-laser-ablation-treatment-long-term-comparison-of-bare-tip-fiber980nm-laser-and-radial-tip-fiber1470nm-laser-application
#3
Ümit Arslan, Eyüpserhat Çalık, Mehmet Tort, Ziya Yıldız, Ali İhsan Tekin, Hüsnü Kamil Limandal, Mehmet Ali Kaygın, Özgür Dağ, Bilgehan Erkut
BACKGROUND: Varices and venous insufficiency are common and serious health problems in the general population which affect quality of life. Endothermal treatment of the great saphenous vein has become the first line of treatment for superficial venous reflux, and the endovenous laser ablation (EVLA) method has been widely accepted all over the world. In this method, ablation is provided by a laser fiber inserted into the lumen of the vein. Initially, the fibers were 810 nm, but today the fibers are usually 940, 980, or 1470 nm...
June 21, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28646092/deletion-analysis-of-agd1-reveals-domains-crucial-for-its-plasma-membrane-recruitment-and-function-in-root-hair-polarity
#4
Cheol-Min Yoo, Satoshi Naramoto, J Alan Sparks, Bibi Rafeiza Khan, Jin Nakashima, Hiroo Fukuda, Elison B Blancaflor
AGD1, a plant ACAP-type ADP-ribosylation factor-GTPase activating protein (ARF-GAP), functions in specifying root hair polarity in Arabidopsis thaliana To better understand how AGD1 modulates root hair growth, we generated full length and domain-deleted AGD1-green fluorescent protein (GFP) constructs, and followed their localization during root hair development. AGD1-GFP localized to the cytoplasm and was recruited to specific regions of the root hair plasma membrane (PM). Distinct PM AGD1-GFP signal was first detected along the site of root hair bulge formation...
June 23, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28645796/preclinical-testing-of-frequency-tunable-capacitive-micromachined-ultrasonic-transducer-probe-prototypes
#5
Martin Pekař, Alexander F Kolen, Harm Belt, Frank van Heesch, Nenad Mihajlović, Imo E Hoefer, Tamas Szili-Török, Hendrik J Vos, Johan G Bosch, Gijs van Soest, Antonius F W van der Steen
In intracardiac echocardiography (ICE) it may be beneficial to generate ultrasound images acquired at multiple frequencies, having the possibility of high penetration or high-resolution imaging in a single device. The objective of the presented work is to test two frequency-tunable probe prototypes in a preclinical setting: a rigid probe having a diameter of 11 mm and a new flexible and steerable 12-Fr ICE catheter. Both probes feature a forward-looking 32-element capacitive micromachined ultrasonic transducer array (aperture of 2 × 2 mm(2)) operated in collapse mode, which allows for frequency tuning in the 6-MHz-18-MHz range...
June 20, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28645423/a-technique-for-extraction-of-the-distal-segment-of-a-broken-femoral-nail-using-a-flexible-reamer
#6
C Zhao, G J R Slater
INTRODUCTION: Extraction of broken femoral nails in peri-implant fractures is becoming an increasingly common problem faced by orthopaedic surgeons. Different closed and open techniques for removal of broken nails have been previously described but due to variations in equipment and fracture configurations these methods are not always easily reproducible. We describe an open surgical technique using simple equipment that can be utilised when other methods of extraction have failed. CASE PRESENTATION AND SURGICAL TECHNIQUE: We present a case of a peri-implant fracture secondary to non-union involving a short cephalomedullary nail where the broken distal segment of nail was significantly more distal to the femoral fracture site...
June 16, 2017: Injury
https://www.readbyqxmd.com/read/28644633/role-of-preload-in-adhesion-of-rough-surfaces
#7
L Dorogin, A Tiwari, C Rotella, P Mangiagalli, B N J Persson
Adhesion between glass and bromobutyl and polydimethylsiloxane elastomers is investigated. We show that viscoelastic energy dissipation close to the opening (or closing) crack tip, and surface roughness, strongly affect the work of adhesion. We observe strong adhesion hysteresis and we show, in contrast to the Johnson-Kendall-Roberts theory prediction for elastic solids, that this results in a pull-off force, and effective work of adhesion to be dependent on the maximum loading force.
June 9, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28641502/ordering-theories-typologies-and-conceptual-frameworks-for-sociotechnical-change
#8
Benjamin K Sovacool, David J Hess
What theories or concepts are most useful at explaining socio technical change? How can - or cannot - these be integrated? To provide an answer, this study presents the results from 35 semi-structured research interviews with social science experts who also shared more than two hundred articles, reports and books on the topic of the acceptance, adoption, use, or diffusion of technology. This material led to the identification of 96 theories and conceptual approaches spanning 22 identified disciplines. The article begins by explaining its research terms and methods before honing in on a combination of fourteen theories deemed most relevant and useful by the material...
June 1, 2017: Social Studies of Science
https://www.readbyqxmd.com/read/28641240/placing-sites-on-the-edge-of-planar-silicon-microelectrodes-enhances-chronic-recording-functionality
#9
Heui Chang Lee, Janak Gaire, Badrinath Roysam, Kevin J Otto
OBJECTIVE: This study aims to identify the impact of using edge sites over center sites on a planar silicon microelectrode array. METHODS: We used custom-designed, silicon-substrate multi-site microelectrode arrays with sites on the center, edge, and tip. We compared their single unit recording capability, noise level, impedance, and histology to identify the differences between each site location. Wide and narrow devices were used to evaluate if the differences are consistent and meets theoretical expectations...
June 15, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28635248/safety-feasibility-tips-and-tricks-of-permanent-pacemaker-implantation-in-patients-with-isolated-persistent-left-superior-vena-cava
#10
Santosh K Sinha, Vinay Krishna, Ramesh Thakur, Ashutosh Kumar, Karandeep Singh, Mukesh J Jha, Mahamdulla Razi, Vikas Mishra, Mohammad Asif, Nasar Abdali, Dibbendhu Khanra, Amit Goel, Umeshwar Pandey, Chandra M Varma
No abstract text is available yet for this article.
August 2017: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/28633959/characterization-of-the-superior-olivary-complex-of-canis-lupus-domesticus
#11
Tatiana Fech, Lilian Calderón-Garcidueñas, Randy J Kulesza
The superior olivary complex (SOC) is a collection of brainstem auditory nuclei which play essential roles in the localization of sound sources, temporal coding of vocalizations and descending modulation of the cochlea. Notwithstanding, the SOC nuclei vary considerably between species in accordance with the auditory needs of the animal. The canine SOC was subjected to anatomical and physiological examination nearly 50 years ago and was then virtually forgotten. Herein, we aimed to characterize the nuclei of the canine SOC using quantitative morphometrics, estimation of neuronal number, histochemistry for perineuronal nets and immunofluorescence for the calcium binding proteins calbindin and calretinin...
June 15, 2017: Hearing Research
https://www.readbyqxmd.com/read/28631329/inverting-suprastomal-granulomas
#12
Cláudia Schweiger, Catherine K Hart, Robin T Cotton, Michael J Rutter
Although suprastomal granulomas are a common complication of tracheotomy, they usually are an incidental finding and do not always require treatment. However, large granulomas may require removal, either to assist with speech production or to make the airway safer in the event of an accidental decannulation. Very large suprastomal granulomas extending up to or even through the vocal cords have been described. However, inverting suprastomal granulomas extending distally down the length of a tracheotomy tube have not been previously described...
June 20, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28629017/design-of-a-new-nanocomposite-between-bismuth-nanoparticles-and-graphene-oxide-for-development-of-electrochemical-sensors
#13
Eduardo H Bindewald, Arthur F Schibelbain, Maurício A P Papi, Eduardo G C Neiva, Aldo J G Zarbin, Márcio F Bergamini, Luiz H Marcolino-Júnior
This study describes a new route for preparation of a nanocomposite between graphene oxide (GO) and bismuth nanoparticles (BiNPs) and its evaluation as modifier electrode for development of electrochemical sensors. BiNPs were synthesized under ultrasound conditions using Bi(NO3)3 as metal precursor and ascorbic acid (AA) as reducing agent/passivating. Some experimental parameters of BiNPs synthesis such as Bi(3+):AA molar ratio and reaction time were conducted aiming the best voltammetric performance of the sensor...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28625782/complex-sexual-deception-in-an-orchid-is-achieved-by-co-opting-two-independent-biosynthetic-pathways-for-pollinator-attraction
#14
Haiyang Xu, Björn Bohman, Darren C J Wong, Claudia Rodriguez-Delgado, Adrian Scaffidi, Gavin R Flematti, Ryan D Phillips, Eran Pichersky, Rod Peakall
Sexually deceptive orchids lure their specific male pollinators using volatile semiochemicals that mimic female sex pheromones. To date, the semiochemicals known to be involved consist of blends of chemically and biosynthetically related compounds. In contrast, we report that (S)-β-citronellol and 2-hydroxy-6-methylacetophenone, two biosynthetically distinct compounds, are the active semiochemicals in Caladenia plicata, which is pollinated by male Zeleboria sp. thynnine wasps. They are also sex pheromone components of the female Zeleboria...
June 12, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28623369/looking-beyond-the-imaging-plane-3d-needle-tracking-with-a-linear-array-ultrasound-probe
#15
Wenfeng Xia, Simeon J West, Malcolm C Finlay, Jean-Martial Mari, Sebastien Ourselin, Anna L David, Adrien E Desjardins
Ultrasound is well suited for guiding many minimally invasive procedures, but its use is often precluded by the poor visibility of medical devices. When devices are not visible, they can damage critical structures, with life-threatening complications. Here, we developed the first ultrasound probe that comprises both focused and unfocused transducer elements to provide both 2D B-mode ultrasound imaging and 3D ultrasonic needle tracking. A fibre-optic hydrophone was integrated into a needle to receive Golay-coded transmissions from the probe and these data were processed to obtain tracking images of the needle tip...
June 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28622147/brachiocephalic-vein-perforation-during-cannulation-of-internal-jugular-vein-a-case-report
#16
Atsushi Kainuma, Keiichi Oshima, Chiho Ota, Yu Okubo, Naoto Fukunaga, Soon Hak Suh
We report a rare complication of right brachiocephalic vein perforation during ultrasound-guided cannulation of the right internal jugular vein (IJV) in a patient with a tortuous common carotid artery (CCA). We suspect that the tortuous CCA displaced the IJV, which caused misplacement of the J-tip guidewire into the subclavian vein. The stiff dilator sheath introduced over the guidewire then perforated the wall of the brachiocephalic vein, causing massive hemothorax. This was diagnosed by videothoracoscopy...
June 15, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/28619443/ct-guided-hook-wire-localisation-prior-to-video-assisted-thoracoscopic-surgery-of-pulmonary-lesions
#17
T Gruber-Rouh, N N N Naguib, M Beeres, P Kleine, T J Vogl, V Jacobi, M Alsubhi, N A Nour-Eldin
AIM: To assess the feasibility, safety, and efficacy of computed tomography (CT)-guided pulmonary nodule localisation using a hooked guide wire before video-assisted thoracoscopic surgery (VATS). MATERIALS AND METHODS: The study included 79 patients with a history of malignancies outside the lung associated with pulmonary nodules. Mean lesion size was 0.7 cm (range 0.5-1.8 cm) and the mean lesion distance to the pleural surface was 1.5 cm (range 0.2-5 cm). All lesions (n=82) were marked with a 22-G hook wire...
June 12, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28613886/electrochemical-size-measurement-and-characterization-of-electrodeposited-platinum-nanoparticles-at-nanometer-resolution-with-scanning-electrochemical-microscopy
#18
Wei Ma, Keke Hu, QianJin Chen, Min Zhou, Michael Mirkin, Allen J Bard
The properties of nanoparticles (NPs) are determined by their size and geometric structure. A reliable determination of NP dimensions is critical for understanding physical and chemical properties, but sizing ultrasmall particles on the nanometer (nm) scale in solution is still challenging. Here, we report the size measurement of PtNPs at nm resolution by in-situ scanning electrochemical microscopy (SECM), performed with the electrochemical generation and removal of H2 bubbles at a small distance between tip and substrate in 200 mM or 500 mM HClO4 solution...
June 14, 2017: Nano Letters
https://www.readbyqxmd.com/read/28613372/cleaning-cassava-genotypes-infected-with-cassava-frogskin-disease-via-in-vitro-shoot-tip-culture
#19
M J S Carvalho, E J Oliveira, A S Souza, J S Pereira, M S A S Diamantino, S A S Oliveira
This study aimed to develop a methodology for eliminating cassava frogskin disease (CFSD) from in vitro shoot tip culture by associating thermotherapy and tetracycline. Cuttings from different accessions (BGM0232, BGM0315, BGM0464, BGM584, BGM0841, and BGM1342), infected with CFSD according to visual inspection of the disease symptoms, were used for cleaning. To verify the absence of other diseases, the plants were indexed for Cassava common mosaic virus - CsCMV (by ELISA) and Cassava vein mosaic virus - CsVMV (by polymerase chain reaction, PCR), proving that the accessions were free of these viruses, except for BGM0315 and BGM0464, which were infected with CsVMV...
May 31, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28609996/the-taxonomic-placement-of-three-fossil-i-fundulus-i-species-and-the-timing-of-divergence-within-the-north-american-topminnows-teleostei-fundulidae
#20
Michael J Ghedotti, Matthew P Davis
The fossils species †Fundulus detillae, †F. lariversi, and †F. nevadensis from localities in the western United States are represented by well-preserved material with date estimations. We combined morphological data for these fossil taxa with morphological and DNA-sequence data to conduct a phylogenetic analysis and a tip-based divergence-time estimation for the family Fundulidae. The resultant phylogeny is largely concordant with the prior total-evidence phylogeny. The fossil species do not form a monophyletic group, and do not represent a discrete western radiation of Fundulus as previously proposed...
April 10, 2017: Zootaxa
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