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https://www.readbyqxmd.com/read/28543771/right-ventricular-pacemaker-lead-position-is-associated-with-differences-in-long-term-outcomes-and-complications
#1
Chance M Witt, Charles J Lenz, Henry H Shih, Elisa Ebrille, Andrew N Rosenbaum, Martin van Zyl, Htin Aung, Kevin K Manocha, Abhishek J Deshmukh, David O Hodge, Siva K Mulpuru, Yong-Mei Cha, Raul E Espinosa, Samuel J Asirvatham, Christopher J McLeod
INTRODUCTION: Cardiac pacing from the right ventricular apex is associated with detrimental long-term effects and non-apical pacing locations may be associated with improved outcomes. There is little data regarding complications with non-apical lead positions. The aim of this study was to assess long-term outcomes and lead-related complications associated with differing ventricular lead tip position. METHODS AND RESULTS: All adult patients who underwent dual-chamber pacemaker implantation from 2004-2014 were included if they had post-procedure chest radiographs amenable to lead position determination...
May 24, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28542716/improving-needle-tip-identification-during-ultrasound-guided-procedures-in-anaesthetic-practice
#2
REVIEW
H J Scholten, A Pourtaherian, N Mihajlovic, H H M Korsten, R A Bouwman
Ultrasound guidance is becoming standard practice for needle-based interventions in anaesthetic practice, such as vascular access and peripheral nerve blocks. However, difficulties in aligning the needle and the transducer can lead to incorrect identification of the needle tip, possibly damaging structures not visible on the ultrasound screen. Additional techniques specifically developed to aid alignment of needle and probe or identification of the needle tip are now available. In this scoping review, advantages and limitations of the following categories of those solutions are presented: needle guides; alterations to needle or needle tip; three- and four-dimensional ultrasound; magnetism, electromagnetic or GPS systems; optical tracking; augmented (virtual) reality; robotic assistance; and automated (computerised) needle detection...
May 22, 2017: Anaesthesia
https://www.readbyqxmd.com/read/28541500/prophylactic-efficacy-of-hyperimmune-bovine-colostral-antiadhesin-antibodies-against-enterotoxigenic-escherichia-coli-diarrhea-a-randomized-double-blind-placebo-controlled-phase-1-trial
#3
Stephen J Savarino, Robin McKenzie, David R Tribble, Chad K Porter, Aisling O'Dowd, Joyce A Cantrell, Stephanie A Sincock, Steven T Poole, Barbara DeNearing, Colleen M Woods, Hye Kim, Shannon L Grahek, Carl Brinkley, Joseph H Crabb, A Louis Bourgeois
Background.: Tip-localized adhesive proteins of bacterial fimbriae from diverse pathogens confer protection in animal models, but efficacy in humans has not been reported. Enterotoxigenic Escherichia coli (ETEC) commonly elaborate colonization factors comprising a minor tip adhesin and major stalk-forming subunit. We assessed the efficacy of antiadhesin bovine colostral IgG (bIgG) antibodies against ETEC challenge in volunteers. Methods.: Adults were randomly assigned (1:1:1) to take oral hyperimmune bIgG raised against CFA/I minor pilin subunit (CfaE) tip adhesin or colonization factor I (CFA/I) fimbraie (positive control) or placebo...
May 24, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28536513/proximity-of-substantia-nigra-microstimulation-to-putative-gabaergic-neurons-predicts-modulation-of-human-reinforcement-learning
#4
Ashwin G Ramayya, Isaac Pedisich, Deborah Levy, Anastasia Lyalenko, Paul Wanda, Daniel Rizzuto, Gordon H Baltuch, Michael J Kahana
Neuronal firing in the substantia nigra (SN) immediately following reward is thought to play a crucial role in human reinforcement learning. As in Ramayya et al. (2014a) we applied microstimulation in the SN of patients undergoing deep brain stimulation (DBS) for the treatment of Parkinson's disease as they engaged in a two-alternative reinforcement learning task. We obtained microelectrode recordings to assess the proximity of the electrode tip to putative dopaminergic and GABAergic SN neurons and applied stimulation to assess the functional importance of these neuronal populations for learning...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28534521/comprehensive-analysis-of-adverse-events-associated-with-per-oral-endoscopic-myotomy-in-1826-patients-an-international-multicenter-study
#5
Yamile Haito-Chavez, Haruhiro Inoue, Kristin W Beard, Peter V Draganov, Michael Ujiki, Burkhard H A Rahden, Pankaj N Desai, Mathieu Pioche, Bu Hayee, Amyn Haji, Payal Saxena, Kevin Reavis, Manabu Onimaru, Valerio Balassone, Jun Nakamura, Yoshitaka Hata, Dennis Yang, Davinderbir Pannu, Ali Abbas, Yaseen B Perbtani, Lava Y Patel, Jorg Filser, Sabine Roman, Jerome Rivory, Francois Mion, Thierry Ponchon, Silvana Perretta, Vivien Wong, Roberta Maselli, Saowanee Ngamruengphong, Yen-I Chen, Majidah Bukhari, Gulara Hajiyeva, Amr Ismail, Renata Pieratti, Vivek Kumbhari, Gerson Galdos-Cardenas, Alessandro Repici, Mouen A Khashab
OBJECTIVES: The safety of peroral endoscopic myotomy (POEM) is still debated since comprehensive analysis of adverse events (AEs) associated with the procedure in large multicenter cohort studies has not been performed. To study (1) the prevalence of AEs and (2) factors associated with occurrence of AEs in patients undergoing POEM. METHODS: Patients who underwent POEM at 12 tertiary-care centers between 2009 and 2015 were included in this case-control study. Cases were defined by the occurrence of any AE related to the POEM procedure...
May 23, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28531220/highly-conserved-type-1-pili-promote-enterotoxigenic-e-coli-pathogen-host-interactions
#6
Alaullah Sheikh, Rasheduzzaman Rashu, Yasmin Ara Begum, F Matthew Kuhlman, Matthew A Ciorba, Scott J Hultgren, Firdausi Qadri, James M Fleckenstein
Enterotoxigenic Escherichia coli (ETEC), defined by their elaboration of heat-labile (LT) and/or heat-stable (ST) enterotoxins, are a common cause of diarrheal illness in developing countries. Efficient delivery of these toxins requires ETEC to engage target host enterocytes. This engagement is accomplished using a variety of pathovar-specific and conserved E. coli adhesin molecules as well as plasmid encoded colonization factors. Some of these adhesins undergo significant transcriptional modulation as ETEC encounter intestinal epithelia, perhaps suggesting that they cooperatively facilitate interaction with the host...
May 22, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28525802/fast-and-reliable-pre-approach-for-scanning-probe-microscopes-based-on-tip-sample-capacitance
#7
J M de Voogd, M A van Spronsen, F E Kalff, B Bryant, O Ostojić, A M J den Haan, I M N Groot, T H Oosterkamp, A F Otte, M J Rost
Within the last three decades Scanning Probe Microscopy has been developed to a powerful tool for measuring surfaces and their properties on an atomic scale such that users can be found nowadays not only in academia but also in industry. This development is still pushed further by researchers, who continuously exploit new possibilities of this technique, as well as companies that focus mainly on the usability. However, although imaging has become significantly easier, the time required for a safe approach (without unwanted tip-sample contact) can be very time consuming, especially if the microscope is not equipped or suited for the observation of the tip-sample distance with an additional optical microscope...
May 10, 2017: Ultramicroscopy
https://www.readbyqxmd.com/read/28524449/technical-feasibility-and-safety-of-image-guided-parieto-occipital-ventricular-catheter-placement-with-the-assistance-of-a-wearable-head-up-display
#8
Jang W Yoon, Robert E Chen, Karim ReFaey, Roberto J Diaz, Ronald Reimer, Ricardo J Komotar, Alfredo Quinones-Hinojosa, Benjamin L Brown, Robert E Wharen
BACKGROUND: Wearable technology is growing in popularity as a result of its ability to interface with normal human movement and function. METHODS: Using proprietary hardware and software, neuronavigation images were captured and transferred wirelessly via a password-encrypted network to the head-up display. The operating surgeon wore a loupe-mounted wearable head-up display during image-guided parieto-occipital ventriculoperitoneal shunt placement in two patients...
May 19, 2017: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
https://www.readbyqxmd.com/read/28521539/jackets-off-the-impact-of-laser-fiber-stripping-on-power-output-and-stone-degradation
#9
Cayde Ritchie, Patrick Yang, Brandon Peplinski, Mohamed Keheila, Salim Cheriyan, Samuel R Abourbih, Wayne Kelln, D Duane Baldwin
PURPOSE: To investigate the effect of laser fiber stripping on stone fragmentation and laser fiber power output. MATERIALS & METHODS: In a benchtop simulation of laser lithotripsy, 20 BegoStone phantoms were positioned within a ureteral model and irradiated for 10 minutes at 8 Hz and 0.8 J. A freshly cleaved 365 μm laser fiber was used for all trials, with half of the fibers also undergoing stripping. Power output was measured at one-minute intervals, beginning with an initial pre-lithotripsy recording at zero minutes...
May 18, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28515846/passive-expansion-of-sub-maximally-dilated-transjugular-intrahepatic-portosystemic-shunts-and-assessment-of-clinical-outcomes
#10
Michael C Hsu, Charles N Weber, S William Stavropoulos, Timothy W Clark, Scott O Trerotola, Richard D Shlansky-Goldberg, Michael C Soulen, Gregory J Nadolski
AIM: To assess for passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts (TIPS) and compare outcomes with maximally dilated TIPS. METHODS: Polytetrafluoroethylene covered TIPS (Viatorr) from July 2002 to December 2013 were retrospectively reviewed at two hospitals in a single institution. Two hundred and thirty patients had TIPS maximally dilated to 10 mm (mTIPS), while 43 patients who were at increased risk for hepatic encephalopathy (HE), based on clinical evaluation or low pre-TIPS portosystemic gradient (PSG), had 10 mm TIPS sub-maximally dilated to 8 mm (smTIPS)...
April 28, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28512687/added-value-of-covered-stents-in-transjugular-intrahepatic-portosystemic-shunt-a-large-single-center-experience
#11
Amar C Gupta, Weiping Wang, Chintan Shah, Mark J Sands, Jennifer Bullen, Erick M Remer, Pilar M Bayona, William Carey, Baljendra Kapoor
PURPOSE: Transjugular intrahepatic portosystemic shunts (TIPS) were historically placed using uncovered bare-metal stents. Current practice has now shifted toward the use of polytetrafluoroethylene (PTFE)-covered stents, given the improved primary patency seen with these stents. The aim of this study was to determine whether there is any added value, such as overall survival or stent patency, when using covered stents versus uncovered stents in TIPS placement in a large cohort. MATERIALS AND METHODS: From April 1995 to June 2012, a total of 744 consecutive adult patients underwent de novo TIPS placement (378 receiving uncovered stents, 366 receiving covered stents)...
May 16, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28512042/the-corona-dentis-description-of-an-anatomical-variant-with-technical-implications-for-anterior-odontoid-screw-placement
#12
Fernando Alonso, Joe Iwanaga, Jens R Chapman, Rod J Oskouian, R Shane Tubbs
INTRODUCTION: Type 2 odontoid fractures are the most common cervical fractures among the elderly. Neurological deficit is usually caused as a result of myelopathy due to posterior dens migration. Direct anterior screw placement provides stabilization and can preserve C1-C2 movement. The presence of a bony excrescence on the anterior superior tip of the dens may lead to placement of a screw of incorrect length. METHODS: Twenty C2 dry specimens were examined for the presence of a corona dentis, which is a bony excrescence in the coronal plane near the apex of the dens...
May 13, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28507864/technical-tip-mark-scarpa-s-fascia-to-facilitate-proper-abdominal-closure-during-autologous-breast-reconstruction
#13
Peter W Henderson, Briar L Dent, Joseph J Disa
No abstract text is available yet for this article.
April 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28507536/temporal-genomic-phylogeny-reconstruction-indicates-a-geospatial-transmission-path-of-salmonella-cerro-in-the-united-states-and-a-clade-specific-loss-of-hydrogen-sulfide-production
#14
Jasna Kovac, Kevin J Cummings, Lorraine D Rodriguez-Rivera, Laura M Carroll, Anil Thachil, Martin Wiedmann
Salmonella Cerro has become one of the most prevalent Salmonella serotypes isolated from dairy cattle in several U.S. states, including New York where it represented 36% of all Salmonella isolates of bovine origin in 2015. This serotype is commonly isolated from dairy cattle with clinical signs of salmonellosis, including diarrhea and fever, although it has also been identified in herds without evidence of clinical disease or decreased production. To better understand the transmission patterns and drivers of its geographic spread, we have studied the genomic similarity and microevolution of S...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28507306/long-term-increases-in-soil-carbon-due-to-ecosystem-fertilization-by-atmospheric-nitrogen-deposition-demonstrated-by-regional-scale-modelling-and-observations
#15
E Tipping, J A C Davies, P A Henrys, G J D Kirk, A Lilly, U Dragosits, E J Carnell, A J Dore, M A Sutton, S J Tomlinson
Fertilization of nitrogen (N)-limited ecosystems by anthropogenic atmospheric nitrogen deposition (Ndep) may promote CO2 removal from the atmosphere, thereby buffering human effects on global radiative forcing. We used the biogeochemical ecosystem model N14CP, which considers interactions among C (carbon), N and P (phosphorus), driven by a new reconstruction of historical Ndep, to assess the responses of soil organic carbon (SOC) stocks in British semi-natural landscapes to anthropogenic change. We calculate that increased net primary production due to Ndep has enhanced detrital inputs of C to soils, causing an average increase of 1...
May 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28506487/a-review-of-monopolar-motor-mapping-and-a-comprehensive-guide-to-continuous-dynamic-motor-mapping-for-resection-of-motor-eloquent-brain-tumors
#16
P Schucht, K Seidel, A Jilch, J Beck, A Raabe
Monopolar mapping of motor function differs from the most commonly used method of intraoperative mapping, i.e. bipolar direct electrical stimulation at 50-60Hz (Penfield technique mapping). Most importantly, the monopolar probe emits a radial, homogenous electrical field different to the more focused inter-tip bipolar electrical field. Most users combine monopolar stimulation with the short train technique, also called high frequency stimulation, or train-of-five techniques. It consists of trains of four to nine monopolar rectangular electrical pulses of 200-500μs pulse length with an inter stimulus interval of 2-4msec...
May 12, 2017: Neuro-Chirurgie
https://www.readbyqxmd.com/read/28504460/the-cyclin-dependent-kinase-subunit-cks1-is-required-for-infection-associated-development-of-the-rice-blast-fungus-magnaporthe-oryzae
#17
Xiaofeng Yue, Yawei Que, Shuzhen Deng, Lin Xu, Miriam Oses-Ruiz, Nicholas J Talbot, Youliang Peng, Zhengyi Wang
Cell cycle regulation is pivotal for proper cell division and cellular differentiation in eukaryotic cells. The central regulators that govern eukaryotic cell cycle progression are cyclin-dependent kinases (CDKs) and their partners. Here, we report that Magnaporthe oryzae CKS1 encodes a cyclin-dependent kinase subunit, which plays a significant role in regulation of plant infection. We demonstrate that CKS1 is a functional homolog of CKS1/SUC1 and can physically interact with the CDK protein Cdc28, and Som1, a downstream regulator of the cyclic AMP-dependent Protein Kinase A pathway...
May 15, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28504023/twelve-tips-for-effective-body-language-for-medical-educators
#18
Andrew J Hale, Jason Freed, Daniel Ricotta, Grace Farris, C Christopher Smith
BACKGROUND: A significant proportion of human communication is nonverbal. Although the fields of business and psychology have significant literature on effectively using body language in a variety of situations, there is limited literature on effective body language for medical educators. AIM: To provide 12 tips to highlight effective body language strategies and techniques for medical educators. METHOD: The tips provided are based on our experiences and reflections as clinician-educators and the available literature...
May 14, 2017: Medical Teacher
https://www.readbyqxmd.com/read/28503691/a-rapidly-prototyped-microfluidic-device-for-size-based-nucleic-acid-fractionation-using-isotachophoresis
#19
C Eid, S S Branda, R J Meagher
We present a novel microfluidic device for size-based nucleic acid (NA) fractionation using isotachophoresis (ITP) and an ionic spacer. Our rapid-prototyped laser-cut plastic device has easily modifiable channel dimensions, can process up to 10 μL of sample, and contains an in-line extraction reservoir for minimally-disruptive manual collection of size-fractionated NAs. We designed custom buffering reservoirs using 1 mL pipette tips to provide high buffering capacity and prevent bubbles from entering the microfluidic channels...
May 15, 2017: Analyst
https://www.readbyqxmd.com/read/28503349/medial-malleolar-fractures-an-anatomic-survey-determining-the-ideal-screw-length
#20
P J Labronici, R E Pires, M V Franco, R Freitas, G C Araújo, R S Pires E Albuquerque, V S Gameiro, K Jeray
BACKGROUND: Medial malleolar fractures are frequent, and their treatment is familiar to the orthopedic surgeon. Lag screw fixation using partially threaded screws remains the standard treatment method for medial malleolar fractures. However, the literature lacks a defined method for selecting lag screw length, relying more so on the empiric choice of the surgeon. AIM: The aim of this study is to help define the ideal lag screw length for medial melleolar fracture fixation...
September 2016: Annals of Medical and Health Sciences Research
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