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JOURNAL ARTICLE
Alfredo L Sklar, Xi Ren, Lydia Chlpka, Mark Curtis, Brian A Coffman, Dean F Salisbury
BACKGROUND AND HYPOTHESIS: There is growing appreciation for the contribution of sensory disruptions to disease morbidity in psychosis. The present study examined auditory cortex (AC) dynamic range: the scaling of neurophysiological responses to stimulus intensity, among individuals with a schizophrenia spectrum illness (FESz) and its relationship to clinical outcomes at disease onset. STUDY DESIGN: Magnetoencephalography (MEG) was recorded from 35 FESz and 40 healthy controls (HC) during binaural presentation of tones at three intensities (75 dB, 80 dB, and 85 dB)...
February 7, 2023: Schizophrenia Bulletin
#22
JOURNAL ARTICLE
Sebastian C Coleman, Zelekha A Seedat, Anna C Whittaker, Agatha Lenartowicz, Karen J Mullinger
Post-task responses (PTRs) are transitionary responses occurring for several seconds between the end of a stimulus/task and a period of rest. The most well-studied of these are beta band (13 - 30 Hz) PTRs in motor networks following movement, often called post-movement beta rebounds, which have been shown to differ in patients with schizophrenia and autism. Previous studies have proposed that beta PTRs reflect inhibition of task-positive networks to enable a return to resting brain activity, scaling with cognitive demand and reflecting cortical self-regulation...
December 7, 2022: NeuroImage
#23
REVIEW
Mona Dabiri, Fatemeh Dehghani Firouzabadi, Kun Yang, Peter B Barker, Roland R Lee, David M Yousem
In this review article we have consolidated the imaging literature of patients with schizophrenia across the full spectrum of modalities in radiology including computed tomography (CT), morphologic magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), magnetic resonance spectroscopy (MRS), positron emission tomography (PET), and magnetoencephalography (MEG). We look at the impact of various subtypes of schizophrenia on imaging findings and the changes that occur with medical and transcranial magnetic stimulation (TMS) therapy...
2022: Frontiers in Neuroscience
#24
JOURNAL ARTICLE
Laura Convertino, Daniel Bush, Fanfan Zheng, Rick A Adams, Neil Burgess
The hippocampal formation has been implicated in the pathophysiology of schizophrenia, with patients showing impairments in spatial and relational cognition, structural changes in entorhinal cortex, and reduced theta coherence with medial prefrontal cortex. Both the entorhinal cortex and medial prefrontal cortex exhibit a six-fold (or 'hexadirectional') modulation of neural activity during virtual navigation that is indicative of grid cell populations and associated with accurate spatial navigation. Here, we examined whether these grid-like patterns are disrupted in schizophrenia...
November 10, 2022: Brain
#25
JOURNAL ARTICLE
Yingxin Jia, Kiwamu Kudo, Leighton B N Hinkley, Melissa Fisher, Sophia Vinogradov, Srikantan Nagarajan, Karuna Subramaniam
BACKGROUND AND HYPOTHESIS: Prior research has shown that patients with schizophrenia (SZ) show disruption in brain network connectivity that is thought to underlie their cognitive and psychotic symptoms. However, most studies examining functional network disruption in schizophrenia have focused on the temporally correlated coupling of the strength of network connections. Here, we move beyond correlative metrics to assay causal computations of connectivity changes in directed neural information flow, assayed from a neural source to a target in SZ...
September 8, 2022: Schizophrenia Bulletin
#26
JOURNAL ARTICLE
Toshiaki Onitsuka, Rikako Tsuchimoto, Naoya Oribe, Kevin M Spencer, Yoji Hirano
Recent empirical findings suggest that altered neural synchronization, which is hypothesized to be associated with an imbalance of excitatory (E) and inhibitory (I) neuronal activities, may underlie a core pathophysiological mechanism in patients with schizophrenia. The auditory steady-state response (ASSR) examined by electroencephalography (EEG) and magnetoencephalography (MEG) has been proposed as a potential biomarker for evaluating altered neural synchronization in schizophrenia. For this review, we performed a comprehensive literature search for papers published between 1999 and 2021 examining ASSRs in patients with schizophrenia...
September 7, 2022: Psychiatry and Clinical Neurosciences
#27
JOURNAL ARTICLE
Matthew M Nour, Katherine Beck, Yunzhe Liu, Atheeshaan Arumuham, Mattia Veronese, Oliver D Howes, Raymond J Dolan
Background and Hypotheses: Hippocampal replay and associated high-frequency ripple oscillations are among the best-characterized phenomena in resting brain activity. Replay/ripples support memory consolidation and relational inference, and are regulated by N -methyl-D-aspartate receptors (NMDARs). Schizophrenia has been associated with both replay/ripple abnormalities and NMDAR hypofunction in both clinical samples and genetic mouse models, although the relationship between these 2 facets of hippocampal function has not been tested in humans...
January 2022: Schizophrenia bulletin open
#28
JOURNAL ARTICLE
Oskar Hougaard Jefsen, Yury Shtyrov, Kit Melissa Larsen, Martin J Dietz
OBJECTIVE: Bipolar disorder is characterized by aberrant neurophysiological responses as measured with electroencephalography (EEG) and magnetoencephalography (MEG), including the 40-Hz auditory steady-state response (ASSR). 40-Hz ASSR deficits are also found in patients with schizophrenia and may represent a transdiagnostic biomarker of neuronal circuit dysfunction. In this systematic review and meta-analysis, we summarize and evaluate the evidence for 40-Hz ASSR deficits in patients with bipolar disorder...
July 6, 2022: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
#29
JOURNAL ARTICLE
Alfredo L Sklar, Brian A Coffman, Julia M Longenecker, Mark Curtis, Dean F Salisbury
INTRODUCTION: Aberrant network connectivity is a core deficit in schizophrenia and may underlie many of its associated cognitive deficits. Previous work in first-episode schizophrenia spectrum illness (FESz) suggests preservation of working memory network function during low-load conditions with dysfunction emerging as task complexity increases. This study assessed visual network connectivity and its contribution to load-dependent working memory impairments. METHODS: Magnetoencephalography was recorded from 35 FESz and 28 matched controls (HC) during a lateralized change detection task...
June 28, 2022: Journal of Psychiatric Research
#30
JOURNAL ARTICLE
Po-Lei Lee, Te-Min Lee, Wei-Keung Lee, Narisa Nan Chu, Yuri E Shelepin, Hao-Teng Hsu, Hsiao-Huang Chang
Auditory steady-state response (ASSR) is a translational biomarker for several neurological and psychiatric disorders, such as hearing loss, schizophrenia, bipolar disorder, autism, etc. The ASSR is sinusoidal electroencephalography (EEG)/magnetoencephalography (MEG) responses induced by periodically presented auditory stimuli. Traditional frequency analysis assumes ASSR is a stationary response, which can be analyzed using linear analysis approaches, such as Fourier analysis or Wavelet. However, recent studies have reported that the human steady-state responses are dynamic and can be modulated by the subject's attention, wakefulness state, mental load, and mental fatigue...
July 4, 2022: Journal of Clinical Medicine
#31
REVIEW
Alfred Lenin Fred, Subbiahpillai Neelakantapillai Kumar, Ajay Kumar Haridhas, Sayantan Ghosh, Harishita Purushothaman Bhuvana, Wei Khang Jeremy Sim, Vijayaragavan Vimalan, Fredin Arun Sedly Givo, Veikko Jousmäki, Parasuraman Padmanabhan, Balázs Gulyás
Magnetoencephalography (MEG) plays a pivotal role in the diagnosis of brain disorders. In this review, we have investigated potential MEG applications for analysing brain disorders. The signal-to-noise ratio (SNRMEG = 2.2 db, SNREEG < 1 db) and spatial resolution (SRMEG = 2-3 mm, SREEG = 7-10 mm) is higher for MEG than EEG, thus MEG potentially facilitates accurate monitoring of cortical activity. We found that the direct electrophysiological MEG signals reflected the physiological status of neurological disorders and play a vital role in disease diagnosis...
June 15, 2022: Brain Sciences
#32
JOURNAL ARTICLE
Yegang Hu, Jun Wu, YuJiao Cao, XiaoChen Tang, GuiSen Wu, Qian Guo, LiHua Xu, ZhenYing Qian, YanYan Wei, YingYing Tang, ChunBo Li, Tianhong Zhang, Jijun Wang
Background: Neural oscillations directly reflect the rhythmic changes of brain activities during the resting state or while performing specific tasks. Abnormal neural oscillations have been discovered in patients with schizophrenia. However, there is limited evidence available on abnormal spontaneous neural oscillations in clinical high risk for psychosis (CHR-P). The brain signals recorded by the magnetoencephalography (MEG) technique are not to be disrupted by the skull and scalp. Methods: In this study, we applied the MEG technique to record the resting-state neural activities in CHR-P...
2022: General Psychiatry
#33
REVIEW
Boris Yakubov, Sushmit Das, Reza Zomorrodi, Daniel M Blumberger, Peter G Enticott, Melissa Kirkovski, Tarek K Rajji, Pushpal Desarkar
Cross-frequency coupling (CFC), an electrophysiologically derived measure of oscillatory coupling in the brain, is believed to play a critical role in neuronal computation, learning and communication. It has received much recent attention in the study of both health and disease. We searched for literature that studied CFC during resting state and task-related activities during electroencephalography and magnetoencephalography in psychiatric disorders. Thirty-eight studies were identified, which included attention-deficit hyperactivity disorder, Alzheimer's dementia, autism spectrum disorder, bipolar disorder, depression, obsessive compulsive disorder, social anxiety disorder and schizophrenia...
May 12, 2022: Neuroscience and Biobehavioral Reviews
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JOURNAL ARTICLE
Anne Amalie Elgaard Thorup, Nicoline Hemager, Vibeke Fuglsang Bliksted, Aja Neergaard Greve, Jessica Ohland, Martin Wilms, Sinnika Birkehøj Rohd, Merete Birk, Anette Faurskov Bundgaard, Andreas Færgemand Laursen, Oskar Hougaard Jefsen, Nanna Lawaetz Steffensen, Anna Krogh Andreassen, Lotte Veddum, Christina Bruun Knudsen, Mette Enevoldsen, Marie Nymand, Julie Marie Brandt, Anne Søndergaard, Line Carmichael, Maja Gregersen, Mette Falkenberg Krantz, Birgitte Klee Burton, Martin Dietz, Ron Nudel, Line Korsgaard Johnsen, Kit Melissa Larsen, David Meder, Oliver James Hulme, William Frans Christiaan Baaré, Kathrine Skak Madsen, Torben Ellegaard Lund, Leif Østergaard, Anders Juul, Troels Wesenberg Kjær, Carsten Hjorthøj, Hartwig Roman Siebner, Ole Mors, Merete Nordentoft
Background: Children born to parents with severe mental illness have gained more attention during the last decades because of increasing evidence documenting that these children constitute a population with an increased risk of developing mental illness and other negative life outcomes. Because of high-quality research with cohorts of offspring with familial risk and increased knowledge about gene-environment interactions, early interventions and preventive strategies are now being developed all over the world...
2022: Frontiers in Psychiatry
#35
JOURNAL ARTICLE
Golnoush Alamian, Tarek Lajnef, Annalisa Pascarella, Jean-Marc Lina, Laura Knight, James Walters, Krish D Singh, Karim Jerbi
Schizophrenia has a complex etiology and symptomatology that is difficult to untangle. After decades of research, important advancements toward a central biomarker are still lacking. One of the missing pieces is a better understanding of how non-linear neural dynamics are altered in this patient population. In this study, the resting-state neuromagnetic signals of schizophrenia patients and healthy controls were analyzed in the framework of criticality. When biological systems like the brain are in a state of criticality, they are thought to be functioning at maximum efficiency (e...
2022: Frontiers in Neural Circuits
#36
JOURNAL ARTICLE
Minami Tagawa, Yuichi Takei, Yutaka Kato, Tomohiro Suto, Naruhito Hironaga, Takefumi Ohki, Yumiko Takahashi, Kazuyuki Fujihara, Noriko Sakurai, Koichi Ujita, Yoshito Tsushima, Masato Fukuda
AIMS: Schizophrenia (SZ) is characterized by psychotic symptoms and cognitive impairment, and is hypothesized to be a 'dysconnection' syndrome due to abnormal neural network formation. Although numerous studies have helped elucidate the pathophysiology of SZ, many aspects of the mechanism underlying psychotic symptoms remain unknown. This study used graph theory analysis to evaluate the characteristics of the resting-state network (RSN) in terms of microscale and macroscale indices, and to identify candidates as potential biomarkers of SZ...
July 2022: Psychiatry and Clinical Neurosciences
#37
JOURNAL ARTICLE
Anna-Lisa Schuler, Giulio Ferrazzi, Nigel Colenbier, Giorgio Arcara, Francesco Piccione, Florinda Ferreri, Daniele Marinazzo, Giovanni Pellegrino
OBJECTIVE: Gamma synchrony is a fundamental functional property of the cerebral cortex, impaired in multiple neuropsychiatric conditions (i.e. schizophrenia, Alzheimer's disease, stroke etc.). Auditory stimulation in the gamma range allows to drive gamma synchrony of the entire cortical mantle and to estimate the efficiency of the mechanisms sustaining it. As gamma synchrony depends strongly on the interplay between parvalbumin-positive interneurons and pyramidal neurons, we hypothesize an association between cortical thickness and gamma synchrony...
July 15, 2022: NeuroImage
#38
JOURNAL ARTICLE
S I Dimitriadis, G Perry, S F Foley, K E Tansey, D K Jones, P Holmans, S Zammit, J Hall, M C O'Donovan, M J Owen, K D Singh, D E Linden
Gamma oscillations (30-90 Hz) have been proposed as a signature of cortical visual information processing, particularly the balance between excitation and inhibition, and as a biomarker of neuropsychiatric diseases. Magnetoencephalography (MEG) provides highly reliable visual-induced gamma oscillation estimates, both at sensor and source level. Recent studies have reported a deficit of visual gamma activity in schizophrenia patients, in medication naive subjects, and high-risk clinical participants, but the genetic contribution to such a deficit has remained unresolved...
November 16, 2021: Translational Psychiatry
#39
REVIEW
Paul M Thompson, Neda Jahanshad, Lianne Schmaal, Jessica A Turner, Anderson M Winkler, Sophia I Thomopoulos, Gary F Egan, Peter Kochunov
This Special Issue of Human Brain Mapping is dedicated to a 10-year anniversary of the Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium. It reports updates from a broad range of international neuroimaging projects that pool data from around the world to answer fundamental questions in neuroscience. Since ENIGMA was formed in December 2009, the initiative grew into a worldwide effort with over 2,000 participating scientists from 45 countries, and over 50 working groups leading large-scale studies of human brain disorders...
October 6, 2021: Human Brain Mapping
#40
JOURNAL ARTICLE
Alfredo L Sklar, Brian A Coffman, Dean F Salisbury
Cognitive impairments account for significant morbidity in schizophrenia and are present at disease onset. Controlled processes are particularly susceptible and may contribute to pervasive selective attention deficits. The present study assessed fronto-parietal attention network (FPAN) functioning during cue presentation on a visual search task in first-episode schizophrenia spectrum patients (FE) and its relation to symptom burden and community functioning. Brain activity was recorded with magnetoencephalography from 38 FE and 38 healthy controls (HC) during blocks of pop-out and serial search target detection...
September 2021: Journal of Psychiatric Research
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