keyword
MENU ▼
Read by QxMD icon Read
search

Magnetoencephalography schizophrenia

keyword
https://www.readbyqxmd.com/read/27872809/abnormal-visuomotor-processing-in-schizophrenia
#1
Siân E Robson, Matthew J Brookes, Emma L Hall, Lena Palaniyappan, Jyothika Kumar, Michael Skelton, Nikolaos G Christodoulou, Ayaz Qureshi, Fiesal Jan, Mohammad Z Katshu, Elizabeth B Liddle, Peter F Liddle, Peter G Morris
Subtle disturbances of visual and motor function are known features of schizophrenia and can greatly impact quality of life; however, few studies investigate these abnormalities using simple visuomotor stimuli. In healthy people, electrophysiological data show that beta band oscillations in sensorimotor cortex decrease during movement execution (event-related beta desynchronisation (ERBD)), then increase above baseline for a short time after the movement (post-movement beta rebound (PMBR)); whilst in visual cortex, gamma oscillations are increased throughout stimulus presentation...
2016: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27867941/familial-influences-on-mismatch-negativity-and-its-association-with-plasma-glutamate-level-a-magnetoencephalographic-study-in-twins
#2
Yukika Nishimura, Yuki Kawakubo, Motomu Suga, Kenji Hashimoto, Yuichi Takei, Kunio Takei, Hideyuki Inoue, Masato Yumoto, Ryu Takizawa, Kiyoto Kasai
Mismatch negativity (MMN) or its magnetic counterpart (magnetic mismatch negativity; MMNm) is regarded as a promising biomarker for schizophrenia. Previous electroencephalographic studies of MMN have demonstrated a moderate-to-high heritability for MMN amplitudes. N-methyl-D-aspartate receptor-dependent glutamatergic neurotransmission is implicated in MMN generation. We hypothesized that the differences between identical twins in MMNm variables might be associated with differences in plasma levels of amino acids involved in glutamatergic neurotransmission...
October 2016: Molecular Neuropsychiatry
https://www.readbyqxmd.com/read/27807403/multimodal-classification-of-schizophrenia-patients-with-meg-and-fmri-data-using-static-and-dynamic-connectivity-measures
#3
Mustafa S Cetin, Jon M Houck, Barnaly Rashid, Oktay Agacoglu, Julia M Stephen, Jing Sui, Jose Canive, Andy Mayer, Cheryl Aine, Juan R Bustillo, Vince D Calhoun
Mental disorders like schizophrenia are currently diagnosed by physicians/psychiatrists through clinical assessment and their evaluation of patient's self-reported experiences as the illness emerges. There is great interest in identifying biological markers of prognosis at the onset of illness, rather than relying on the evolution of symptoms across time. Functional network connectivity, which indicates a subject's overall level of "synchronicity" of activity between brain regions, demonstrates promise in providing individual subject predictive power...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27725313/magnetoencephalographic-and-functional-mri-connectomics-in-schizophrenia-via-intra-and-inter-network-connectivity
#4
Jon M Houck, Mustafa S Çetin, Andrew R Mayer, Juan R Bustillo, Julia Stephen, Cheryl Aine, Jose Cañive, Nora Perrone-Bizzozero, Robert J Thoma, Matthew J Brookes, Vince D Calhoun
Examination of intrinsic functional connectivity using functional MRI (fMRI) has provided important findings regarding dysconnectivity in schizophrenia. Extending these results using a complementary neuroimaging modality, magnetoencephalography (MEG), we present the first direct comparison of functional connectivity between schizophrenia patients and controls, using these two modalities combined. We developed a novel MEG approach for estimation of networks using MEG that incorporates spatial independent component analysis (ICA) and pairwise correlations between independent component timecourses, to estimate intra- and intern-network connectivity...
October 7, 2016: NeuroImage
https://www.readbyqxmd.com/read/27219470/inhibition-in-the-human-auditory-cortex
#5
Koji Inui, Kei Nakagawa, Makoto Nishihara, Eishi Motomura, Ryusuke Kakigi
Despite their indispensable roles in sensory processing, little is known about inhibitory interneurons in humans. Inhibitory postsynaptic potentials cannot be recorded non-invasively, at least in a pure form, in humans. We herein sought to clarify whether prepulse inhibition (PPI) in the auditory cortex reflected inhibition via interneurons using magnetoencephalography. An abrupt increase in sound pressure by 10 dB in a continuous sound was used to evoke the test response, and PPI was observed by inserting a weak (5 dB increase for 1 ms) prepulse...
2016: PloS One
https://www.readbyqxmd.com/read/27071182/abnormal-neural-oscillations-in-schizophrenia-assessed-by-spectral-power-ratio-of-meg-during-word-processing
#6
Tingting Xu, Massoud Stephane, Keshab K Parhi
This study investigated spectral power of neural oscillations associated with word processing in schizophrenia. Magnetoencephalography (MEG) data were acquired from 12 schizophrenia patients and 10 healthy controls during a visual word processing task. Two spectral power ratio (SPR) feature sets: the band power ratio (BPR) and the window power ratio (WPR) were extracted from MEG data in five frequency bands, four time windows of word processing, and at locations covering whole head. Cluster-based nonparametric permutation tests were employed to identify SPRs that show significant between-group difference...
November 2016: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/26993787/neural-correlates-of-cognitive-improvements-following-cognitive-remediation-in-schizophrenia-a-systematic-review-of-randomized-trials
#7
REVIEW
Clémence Isaac, Dominique Januel
BACKGROUND: Cognitive impairments are a core feature in schizophrenia and are linked to poor social functioning. Numerous studies have shown that cognitive remediation can enhance cognitive and functional abilities in patients with this pathology. The underlying mechanism of these behavioral improvements seems to be related to structural and functional changes in the brain. However, studies on neural correlates of such enhancement remain scarce. OBJECTIVES: We explored the neural correlates of cognitive enhancement following cognitive remediation interventions in schizophrenia and the differential effect between cognitive training and other therapeutic interventions or patients' usual care...
2016: Socioaffective Neuroscience & Psychology
https://www.readbyqxmd.com/read/26933842/frequency-specific-disruptions-of-neuronal-oscillations-reveal-aberrant-auditory-processing-in-schizophrenia
#8
Lauren K Hayrynen, Jordan P Hamm, Scott R Sponheim, Brett A Clementz
Individuals with schizophrenia exhibit abnormalities in evoked brain responses in oddball paradigms. These could result from (a) insufficient salience-related cortical signaling (P300), (b) insufficient suppression of irrelevant aspects of the auditory environment, or (c) excessive neural noise. We tested whether disruption of ongoing auditory steady-state responses at predetermined frequencies informed which of these issues contribute to auditory stimulus relevance processing abnormalities in schizophrenia...
June 2016: Psychophysiology
https://www.readbyqxmd.com/read/26853904/abnormal-salience-signaling-in-schizophrenia-the-role-of-integrative-beta-oscillations
#9
Elizabeth B Liddle, Darren Price, Lena Palaniyappan, Matthew J Brookes, Siân E Robson, Emma L Hall, Peter G Morris, Peter F Liddle
Aberrant salience attribution and cerebral dysconnectivity both have strong evidential support as core dysfunctions in schizophrenia. Aberrant salience arising from an excess of dopamine activity has been implicated in delusions and hallucinations, exaggerating the significance of everyday occurrences and thus leading to perceptual distortions and delusional causal inferences. Meanwhile, abnormalities in key nodes of a salience brain network have been implicated in other characteristic symptoms, including the disorganization and impoverishment of mental activity...
April 2016: Human Brain Mapping
https://www.readbyqxmd.com/read/26699665/the-effects-of-ketamine-on-the-mismatch-negativity-mmn-in-humans-a-meta-analysis
#10
Timm Rosburg, Ilonka Kreitschmann-Andermahr
OBJECTIVE: To investigate whether effects of the glutamatergic N-methyl-d-aspartate (NMDA) receptor antagonist ketamine on the mismatch negativity (MMN) vary between duration and frequency deviants, as suggested by clinical studies on schizophrenia patients. METHODS: Our meta-analysis included previous studies that used ketamine in order to induce psychotic experiences in healthy participants and that recorded the MMN either by electroencephalography or magnetoencephalography...
February 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/26281716/abnormal-gamma-oscillations-in-n-methyl-d-aspartate-receptor-hypofunction-models-of-schizophrenia
#11
REVIEW
Monika P Jadi, M Margarita Behrens, Terrence J Sejnowski
N-methyl-D-aspartate receptor (NMDAR) hypofunction in parvalbumin-expressing (PV+) inhibitory neurons (INs) may contribute to symptoms in patients with schizophrenia (SZ). This hypothesis was inspired by studies in humans involving NMDAR antagonists that trigger SZ symptoms. Animal models of SZ using neuropharmacology and genetic knockouts have successfully replicated some of the key observations in human subjects involving alteration of gamma band oscillations (GBO) observed in electroencephalography and magnetoencephalography signals...
May 1, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/26213111/consensus-paper-of-the-wfsbp-task-force-on-biological-markers-criteria-for-biomarkers-and-endophenotypes-of-schizophrenia-part-i-neurophysiology
#12
REVIEW
Florence Thibaut, Nash N Boutros, Marek Jarema, Bob Oranje, Alkomiet Hasan, Zafiris Jeffrey Daskalakis, Adam Wichniak, Andrea Schmitt, Peter Riederer, Peter Falkai
The neurophysiological components that have been proposed as biomarkers or as endophenotypes for schizophrenia can be measured through electroencephalography (EEG) and magnetoencephalography (MEG), transcranial magnetic stimulation (TMS), polysomnography (PSG), registration of event-related potentials (ERPs), assessment of smooth pursuit eye movements (SPEM) and antisaccade paradigms. Most of them demonstrate deficits in schizophrenia, show at least moderate stability over time and do not depend on clinical status, which means that they fulfil the criteria as valid endophenotypes for genetic studies...
2015: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/26206861/frontal-slow-wave-activity-as-a-predictor-of-negative-symptoms-cognition-and-functional-capacity-in-schizophrenia
#13
Yu-Han Chen, Breannan Stone-Howell, J Christopher Edgar, Mingxiong Huang, Cassandra Wootton, Michael A Hunter, Brett Y Lu, Joseph R Sadek, Gregory A Miller, José M Cañive
BACKGROUND: Increased temporal and frontal slow-wave delta (1-4 Hz) and theta (4-7 Hz) activities are the most consistent resting-state neural abnormalities reported in schizophrenia. The frontal lobe is associated with negative symptoms and cognitive abilities such as attention, with negative symptoms and impaired attention associated with poor functional capacity. AIMS: To establish whether frontal dysfunction, as indexed by slowing, would be associated with functional impairments...
February 2016: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/26152668/auditory-cortical-plasticity-drives-training-induced-cognitive-changes-in-schizophrenia
#14
Corby L Dale, Ethan G Brown, Melissa Fisher, Alexander B Herman, Anne F Dowling, Leighton B Hinkley, Karuna Subramaniam, Srikantan S Nagarajan, Sophia Vinogradov
Schizophrenia is characterized by dysfunction in basic auditory processing, as well as higher-order operations of verbal learning and executive functions. We investigated whether targeted cognitive training of auditory processing improves neural responses to speech stimuli, and how these changes relate to higher-order cognitive functions. Patients with schizophrenia performed an auditory syllable identification task during magnetoencephalography before and after 50 hours of either targeted cognitive training or a computer games control...
January 2016: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/25987642/ketamine-dysregulates-the-amplitude-and-connectivity-of-high-frequency-oscillations-in-cortical-subcortical-networks-in-humans-evidence-from-resting-state-magnetoencephalography-recordings
#15
RANDOMIZED CONTROLLED TRIAL
Davide Rivolta, Tonio Heidegger, Bertram Scheller, Andreas Sauer, Michael Schaum, Katharina Birkner, Wolf Singer, Michael Wibral, Peter J Uhlhaas
Hypofunctioning of the N-methyl-D-aspartate receptor (NMDA-R) has been prominently implicated in the pathophysiology of schizophrenia (ScZ). The current study tested the effects of ketamine, a dissociative anesthetic and NMDA-R antagonist, on resting-state activity recorded with magnetoencephalography (MEG) in healthy volunteers. In a single-blind cross-over design, each participant (n = 12) received, on 2 different sessions, a subanesthetic dose of S-ketamine (0.006 mg/Kg) and saline injection. MEG-data were analyzed at sensor- and source-level in the beta (13-30 Hz) and gamma (30-90 Hz) frequency ranges...
September 2015: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/25886553/complexity-measures-in-magnetoencephalography-measuring-disorder-in-schizophrenia
#16
Matthew J Brookes, Emma L Hall, Siân E Robson, Darren Price, Lena Palaniyappan, Elizabeth B Liddle, Peter F Liddle, Stephen E Robinson, Peter G Morris
This paper details a methodology which, when applied to magnetoencephalography (MEG) data, is capable of measuring the spatio-temporal dynamics of 'disorder' in the human brain. Our method, which is based upon signal entropy, shows that spatially separate brain regions (or networks) generate temporally independent entropy time-courses. These time-courses are modulated by cognitive tasks, with an increase in local neural processing characterised by localised and transient increases in entropy in the neural signal...
2015: PloS One
https://www.readbyqxmd.com/read/25757652/modulation-of-hippocampal-theta-and-hippocampal-prefrontal-cortex-function-by-a-schizophrenia-risk-gene
#17
Helena Cousijn, Elizabeth M Tunbridge, Michal Rolinski, George Wallis, Giles L Colclough, Mark W Woolrich, Anna C Nobre, Paul J Harrison
Hippocampal theta-band oscillations are thought to facilitate the co-ordination of brain activity across distributed networks, including between the hippocampus and prefrontal cortex (PFC). Impairments in hippocampus-PFC functional connectivity are implicated in schizophrenia and are associated with a polymorphism within the ZNF804A gene that shows a genome-wide significant association with schizophrenia. However, the mechanisms by which ZNF804A affects hippocampus-PFC connectivity are unknown. We used a multimodal imaging approach to investigate the impact of the ZNF804A polymorphism on hippocampal theta and hippocampal network coactivity...
June 2015: Human Brain Mapping
https://www.readbyqxmd.com/read/25676489/oscillations-and-neuronal-dynamics-in-schizophrenia-the-search-for-basic-symptoms-and-translational-opportunities
#18
REVIEW
Peter J Uhlhaas, Wolf Singer
A considerable body of work over the last 10 years combining noninvasive electrophysiology (electroencephalography/magnetoencephalography) in patient populations with preclinical research has contributed to the conceptualization of schizophrenia as a disorder associated with aberrant neural dynamics and disturbances in excitation/inhibition balance. This complements previous research that has largely focused on the identification of abnormalities in circumscribed brain regions and on disturbances of dopaminergic mechanisms as a cause of positive symptoms and executive deficits...
June 15, 2015: Biological Psychiatry
https://www.readbyqxmd.com/read/25497223/abnormal-affect-specific-modulatory-effects-on-early-auditory-processing-in-schizophrenia-magnetoencephalographic-evidence
#19
Markus Junghöfer, Ann-Kathrin Bröckelmann, Kerstin Küppers, Patricia Ohrmann, Anya Pedersen
Abnormalities in the perception and identification of emotions have frequently been reported in schizophrenia. Hemodynamic neuroimaging studies found functional abnormalities in cortical and subcortical brain circuits that are involved in normal affective processing, but the temporal dynamics of abnormal emotion processing in schizophrenia remain largely elusive. To investigate this issue, we recorded early auditory evoked field components by means of whole-head magnetoencephalography that were in response to emotion-associated tones in seventeen patients with schizophrenia and in seventeen healthy, matched controls...
February 2015: Schizophrenia Research
https://www.readbyqxmd.com/read/25468188/overlapping-auditory-m100-and-m200-abnormalities-in-schizophrenia-and-bipolar-disorder-a-meg-study
#20
COMPARATIVE STUDY
Ying Wang, Yanbin Jia, Yigang Feng, Shuming Zhong, Yanping Xie, Wensheng Wang, Yufang Guan, Dan Zhu, Li Huang
OBJECTIVES: Schizophrenia and bipolar disorder share common etiological factors and pathophysiological pathways and have overlapping clinical features. Only few studies have directly compared early auditory information processing in the two disorders. The objective of this study was to investigate the M100 and M200 auditory responses in patients with schizophrenia and bipolar disorder and compare them with healthy controls using magnetoencephalography (MEG). METHODS: Whole-head MEG data were acquired during an auditory oddball paradigm in 24 schizophrenia patients, 26 bipolar I disorder patients, and 31 healthy controls...
December 2014: Schizophrenia Research
keyword
keyword
45139
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"