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Magnetoencephalography schizophrenia

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https://www.readbyqxmd.com/read/28612661/is-there-an-association-between-mismatch-negativity-and-cortical-thickness-in-schizophrenia-patients
#1
Jiyoon J Seol, Minah Kim, Kwang Hyuk Lee, Ji-Won Hur, Kang Ik K Cho, Tae Young Lee, Chun Kee Chung, Jun Soo Kwon
INTRODUCTION: Mismatch negativity (MMN) is thought to reflect preattentive, automatic auditory processing. Reduced MMN amplitude is among the most robust findings in schizophrenia research. MMN generators have been shown to be located in the temporal and frontal cortices, which are key areas in the pathophysiology of schizophrenia. This study investigated whether frontotemporal cortical thickness was associated with reduced MMN current source density (CSD) strength in patients with schizophrenia...
June 1, 2017: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
https://www.readbyqxmd.com/read/28542290/new-paradigm-for-auditory-paired-pulse-suppression
#2
Nobuyuki Takeuchi, Shunsuke Sugiyama, Koji Inui, Kousuke Kanemoto, Makoto Nishihara
Sensory gating is a mechanism of sensory processing used to prevent an overflow of irrelevant information, with some indexes, such as prepulse inhibition (PPI) and P50 suppression, often utilized for its evaluation. In addition, those are clinically important for diseases such as schizophrenia. In the present study, we investigated long-latency paired-pulse suppression of change-related cortical responses using magnetoencephalography. The test change-related response was evoked by an abrupt increase in sound pressure by 15 dB in a continuous sound composed of a train of 25-ms pure tones at 65 dB...
2017: PloS One
https://www.readbyqxmd.com/read/28434615/searching-for-cross-diagnostic-convergence-neural-mechanisms-governing-excitation-and-inhibition-balance-in-schizophrenia-and-autism-spectrum-disorders
#3
REVIEW
Jennifer H Foss-Feig, Brendan D Adkinson, Jie Lisa Ji, Genevieve Yang, Vinod H Srihari, James C McPartland, John H Krystal, John D Murray, Alan Anticevic
Recent theoretical accounts have proposed excitation and inhibition (E/I) imbalance as a possible mechanistic, network-level hypothesis underlying neural and behavioral dysfunction across neurodevelopmental disorders, particularly autism spectrum disorder (ASD) and schizophrenia (SCZ). These two disorders share some overlap in their clinical presentation as well as convergence in their underlying genes and neurobiology. However, there are also clear points of dissociation in terms of phenotypes and putatively affected neural circuitry...
May 15, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28424797/magnetoencephalography-as-a-tool-in-psychiatric-research-current-status-and-perspective
#4
REVIEW
Peter J Uhlhaas, Peter Liddle, David E J Linden, Anna C Nobre, Krish D Singh, Joachim Gross
The application of neuroimaging to provide mechanistic insights into circuit dysfunctions in major psychiatric conditions and the development of biomarkers are core challenges in current psychiatric research. We propose that recent technological and analytic advances in magnetoencephalography (MEG), a technique that allows measurement of neuronal events directly and noninvasively with millisecond resolution, provides novel opportunities to address these fundamental questions. Because of its potential in delineating normal and abnormal brain dynamics, we propose that MEG provides a crucial tool to advance our understanding of pathophysiological mechanisms of major neuropsychiatric conditions, such as schizophrenia, autism spectrum disorders, and the dementias...
April 2017: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/28235554/mismatch-field-latency-but-not-power-may-mark-a-shared-autistic-and-schizotypal-trait-phenotype
#5
Talitha C Ford, Will Woods, David P Crewther
The auditory mismatch negativity (MMN), a preattentive processing potential, and its magnetic counterpart (MMF) are consistently reported as reduced in schizophrenia and autism spectrum disorders. This study investigates whether MMF characteristics differ between subclinically high and low scorers on the recently discovered shared autism and schizophrenia phenotype, Social Disorganisation. A total of 18 low (10 females) and 19 high (9 females) Social Disorganisation scorers underwent magnetoencephalography (MEG) during a MMF paradigm of 50ms standard (1000Hz, 85%) and 100ms duration deviant tones...
February 21, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/28125984/the-youth-mental-health-risk-and-resilience-study-your-study
#6
Peter J Uhlhaas, Ruchika Gajwani, Joachim Gross, Andrew I Gumley, Stephen M Lawrie, Matthias Schwannauer
BACKGROUND: The transition from adolescence to adulthood is associated with the emergence of psychosis and other mental health problems, highlighting the importance of this developmental period for the understanding of developing psychopathology and individual differences in risk and resilience. The Youth Mental Health Risk and Resilience Study (YouR-Study) aims to identify neurobiological mechanisms and predictors of psychosis-risk with a state-of-the-art neuroimaging approach (Magnetoencephalography, Magnetic Resonance Spectroscopy, Magnetic Resonance Imaging) in combination with core psychological processes, such as affect regulation and attachment, that have been implicated in the development and maintenance of severe mental health problems...
January 26, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/27872809/abnormal-visuomotor-processing-in-schizophrenia
#7
Siân E Robson, Matthew J Brookes, Emma L Hall, Lena Palaniyappan, Jyothika Kumar, Michael Skelton, Nikolaos G Christodoulou, Ayaz Qureshi, Fiesal Jan, Mohammad Z Katshu, Elizabeth B Liddle, Peter F Liddle, Peter G Morris
Subtle disturbances of visual and motor function are known features of schizophrenia and can greatly impact quality of life; however, few studies investigate these abnormalities using simple visuomotor stimuli. In healthy people, electrophysiological data show that beta band oscillations in sensorimotor cortex decrease during movement execution (event-related beta desynchronisation (ERBD)), then increase above baseline for a short time after the movement (post-movement beta rebound (PMBR)); whilst in visual cortex, gamma oscillations are increased throughout stimulus presentation...
2016: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27867941/familial-influences-on-mismatch-negativity-and-its-association-with-plasma-glutamate-level-a-magnetoencephalographic-study-in-twins
#8
Yukika Nishimura, Yuki Kawakubo, Motomu Suga, Kenji Hashimoto, Yuichi Takei, Kunio Takei, Hideyuki Inoue, Masato Yumoto, Ryu Takizawa, Kiyoto Kasai
Mismatch negativity (MMN) or its magnetic counterpart (magnetic mismatch negativity; MMNm) is regarded as a promising biomarker for schizophrenia. Previous electroencephalographic studies of MMN have demonstrated a moderate-to-high heritability for MMN amplitudes. N-methyl-D-aspartate receptor-dependent glutamatergic neurotransmission is implicated in MMN generation. We hypothesized that the differences between identical twins in MMNm variables might be associated with differences in plasma levels of amino acids involved in glutamatergic neurotransmission...
October 2016: Molecular Neuropsychiatry
https://www.readbyqxmd.com/read/27807403/multimodal-classification-of-schizophrenia-patients-with-meg-and-fmri-data-using-static-and-dynamic-connectivity-measures
#9
Mustafa S Cetin, Jon M Houck, Barnaly Rashid, Oktay Agacoglu, Julia M Stephen, Jing Sui, Jose Canive, Andy Mayer, Cheryl Aine, Juan R Bustillo, Vince D Calhoun
Mental disorders like schizophrenia are currently diagnosed by physicians/psychiatrists through clinical assessment and their evaluation of patient's self-reported experiences as the illness emerges. There is great interest in identifying biological markers of prognosis at the onset of illness, rather than relying on the evolution of symptoms across time. Functional network connectivity, which indicates a subject's overall level of "synchronicity" of activity between brain regions, demonstrates promise in providing individual subject predictive power...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27725313/magnetoencephalographic-and-functional-mri-connectomics-in-schizophrenia-via-intra-and-inter-network-connectivity
#10
Jon M Houck, Mustafa S Çetin, Andrew R Mayer, Juan R Bustillo, Julia Stephen, Cheryl Aine, Jose Cañive, Nora Perrone-Bizzozero, Robert J Thoma, Matthew J Brookes, Vince D Calhoun
Examination of intrinsic functional connectivity using functional MRI (fMRI) has provided important findings regarding dysconnectivity in schizophrenia. Extending these results using a complementary neuroimaging modality, magnetoencephalography (MEG), we present the first direct comparison of functional connectivity between schizophrenia patients and controls, using these two modalities combined. We developed a novel MEG approach for estimation of networks using MEG that incorporates spatial independent component analysis (ICA) and pairwise correlations between independent component timecourses, to estimate intra- and intern-network connectivity...
January 15, 2017: NeuroImage
https://www.readbyqxmd.com/read/27219470/inhibition-in-the-human-auditory-cortex
#11
Koji Inui, Kei Nakagawa, Makoto Nishihara, Eishi Motomura, Ryusuke Kakigi
Despite their indispensable roles in sensory processing, little is known about inhibitory interneurons in humans. Inhibitory postsynaptic potentials cannot be recorded non-invasively, at least in a pure form, in humans. We herein sought to clarify whether prepulse inhibition (PPI) in the auditory cortex reflected inhibition via interneurons using magnetoencephalography. An abrupt increase in sound pressure by 10 dB in a continuous sound was used to evoke the test response, and PPI was observed by inserting a weak (5 dB increase for 1 ms) prepulse...
2016: PloS One
https://www.readbyqxmd.com/read/27071182/abnormal-neural-oscillations-in-schizophrenia-assessed-by-spectral-power-ratio-of-meg-during-word-processing
#12
Tingting Xu, Massoud Stephane, Keshab K Parhi
This study investigated spectral power of neural oscillations associated with word processing in schizophrenia. Magnetoencephalography (MEG) data were acquired from 12 schizophrenia patients and 10 healthy controls during a visual word processing task. Two spectral power ratio (SPR) feature sets: the band power ratio (BPR) and the window power ratio (WPR) were extracted from MEG data in five frequency bands, four time windows of word processing, and at locations covering whole head. Cluster-based nonparametric permutation tests were employed to identify SPRs that show significant between-group difference...
November 2016: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/26993787/neural-correlates-of-cognitive-improvements-following-cognitive-remediation-in-schizophrenia-a-systematic-review-of-randomized-trials
#13
REVIEW
Clémence Isaac, Dominique Januel
BACKGROUND: Cognitive impairments are a core feature in schizophrenia and are linked to poor social functioning. Numerous studies have shown that cognitive remediation can enhance cognitive and functional abilities in patients with this pathology. The underlying mechanism of these behavioral improvements seems to be related to structural and functional changes in the brain. However, studies on neural correlates of such enhancement remain scarce. OBJECTIVES: We explored the neural correlates of cognitive enhancement following cognitive remediation interventions in schizophrenia and the differential effect between cognitive training and other therapeutic interventions or patients' usual care...
2016: Socioaffective Neuroscience & Psychology
https://www.readbyqxmd.com/read/26933842/frequency-specific-disruptions-of-neuronal-oscillations-reveal-aberrant-auditory-processing-in-schizophrenia
#14
Lauren K Hayrynen, Jordan P Hamm, Scott R Sponheim, Brett A Clementz
Individuals with schizophrenia exhibit abnormalities in evoked brain responses in oddball paradigms. These could result from (a) insufficient salience-related cortical signaling (P300), (b) insufficient suppression of irrelevant aspects of the auditory environment, or (c) excessive neural noise. We tested whether disruption of ongoing auditory steady-state responses at predetermined frequencies informed which of these issues contribute to auditory stimulus relevance processing abnormalities in schizophrenia...
June 2016: Psychophysiology
https://www.readbyqxmd.com/read/26853904/abnormal-salience-signaling-in-schizophrenia-the-role-of-integrative-beta-oscillations
#15
Elizabeth B Liddle, Darren Price, Lena Palaniyappan, Matthew J Brookes, Siân E Robson, Emma L Hall, Peter G Morris, Peter F Liddle
Aberrant salience attribution and cerebral dysconnectivity both have strong evidential support as core dysfunctions in schizophrenia. Aberrant salience arising from an excess of dopamine activity has been implicated in delusions and hallucinations, exaggerating the significance of everyday occurrences and thus leading to perceptual distortions and delusional causal inferences. Meanwhile, abnormalities in key nodes of a salience brain network have been implicated in other characteristic symptoms, including the disorganization and impoverishment of mental activity...
April 2016: Human Brain Mapping
https://www.readbyqxmd.com/read/26699665/the-effects-of-ketamine-on-the-mismatch-negativity-mmn-in-humans-a-meta-analysis
#16
Timm Rosburg, Ilonka Kreitschmann-Andermahr
OBJECTIVE: To investigate whether effects of the glutamatergic N-methyl-d-aspartate (NMDA) receptor antagonist ketamine on the mismatch negativity (MMN) vary between duration and frequency deviants, as suggested by clinical studies on schizophrenia patients. METHODS: Our meta-analysis included previous studies that used ketamine in order to induce psychotic experiences in healthy participants and that recorded the MMN either by electroencephalography or magnetoencephalography...
February 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/26281716/abnormal-gamma-oscillations-in-n-methyl-d-aspartate-receptor-hypofunction-models-of-schizophrenia
#17
REVIEW
Monika P Jadi, M Margarita Behrens, Terrence J Sejnowski
N-methyl-D-aspartate receptor (NMDAR) hypofunction in parvalbumin-expressing (PV+) inhibitory neurons (INs) may contribute to symptoms in patients with schizophrenia (SZ). This hypothesis was inspired by studies in humans involving NMDAR antagonists that trigger SZ symptoms. Animal models of SZ using neuropharmacology and genetic knockouts have successfully replicated some of the key observations in human subjects involving alteration of gamma band oscillations (GBO) observed in electroencephalography and magnetoencephalography signals...
May 1, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/26213111/consensus-paper-of-the-wfsbp-task-force-on-biological-markers-criteria-for-biomarkers-and-endophenotypes-of-schizophrenia-part-i-neurophysiology
#18
REVIEW
Florence Thibaut, Nash N Boutros, Marek Jarema, Bob Oranje, Alkomiet Hasan, Zafiris Jeffrey Daskalakis, Adam Wichniak, Andrea Schmitt, Peter Riederer, Peter Falkai
The neurophysiological components that have been proposed as biomarkers or as endophenotypes for schizophrenia can be measured through electroencephalography (EEG) and magnetoencephalography (MEG), transcranial magnetic stimulation (TMS), polysomnography (PSG), registration of event-related potentials (ERPs), assessment of smooth pursuit eye movements (SPEM) and antisaccade paradigms. Most of them demonstrate deficits in schizophrenia, show at least moderate stability over time and do not depend on clinical status, which means that they fulfil the criteria as valid endophenotypes for genetic studies...
2015: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/26206861/frontal-slow-wave-activity-as-a-predictor-of-negative-symptoms-cognition-and-functional-capacity-in-schizophrenia
#19
Yu-Han Chen, Breannan Stone-Howell, J Christopher Edgar, Mingxiong Huang, Cassandra Wootton, Michael A Hunter, Brett Y Lu, Joseph R Sadek, Gregory A Miller, José M Cañive
BACKGROUND: Increased temporal and frontal slow-wave delta (1-4 Hz) and theta (4-7 Hz) activities are the most consistent resting-state neural abnormalities reported in schizophrenia. The frontal lobe is associated with negative symptoms and cognitive abilities such as attention, with negative symptoms and impaired attention associated with poor functional capacity. AIMS: To establish whether frontal dysfunction, as indexed by slowing, would be associated with functional impairments...
February 2016: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/26152668/auditory-cortical-plasticity-drives-training-induced-cognitive-changes-in-schizophrenia
#20
RANDOMIZED CONTROLLED TRIAL
Corby L Dale, Ethan G Brown, Melissa Fisher, Alexander B Herman, Anne F Dowling, Leighton B Hinkley, Karuna Subramaniam, Srikantan S Nagarajan, Sophia Vinogradov
Schizophrenia is characterized by dysfunction in basic auditory processing, as well as higher-order operations of verbal learning and executive functions. We investigated whether targeted cognitive training of auditory processing improves neural responses to speech stimuli, and how these changes relate to higher-order cognitive functions. Patients with schizophrenia performed an auditory syllable identification task during magnetoencephalography before and after 50 hours of either targeted cognitive training or a computer games control...
January 2016: Schizophrenia Bulletin
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