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Magnetoencephalography depression

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https://www.readbyqxmd.com/read/29628065/modulating-emotion-perception-opposing-effects-of-inhibitory-and-excitatory-prefrontal-cortex-stimulation
#1
Swantje Notzon, Christian Steinberg, Peter Zwanzger, Markus Junghöfer
BACKGROUND: Excitatory repetitive transcranial magnetic stimulation (rTMS) of the left dorsolateral prefrontal cortex (dlPFC) is approved by the U.S. Food and Drug Administration for the treatment of adult patients with treatment-resistant major depressive disorder (MDD). This stimulation is supposed to restore excitability of prefrontal cortex regions that exhibit diminished regulation of emotion-generative systems in MDD. Based on the valence lateralization hypothesis, inhibitory rTMS of the right dlPFC has also been applied in MDD...
April 2018: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/29601316/clinical-trial-of-the-potassium-channel-activator-diazoxide-for-major-depressive-disorder-halted-due-to-intolerability
#2
Bashkim Kadriu, Shiwen Yuan, Cristan Farmer, Allison C Nugent, Marc S Lener, Mark J Niciu, Minkyung Park, Aaron Yazdian, Elizabeth D Ballard, Fritz A Henn, Ioline D Henter, Lawrence T Park, Carlos A Zarate
BACKGROUND: Some glutamatergic modulators have demonstrated rapid and relatively sustained antidepressant properties in patients with major depressive disorder. Because the potassium channel activator diazoxide increases glutamate uptake via potassium channel activation, we hypothesized that it might exert antidepressant effects by increasing the removal of glutamate from the synaptic cleft, thereby reducing excessive glutamate transmission. METHODS: This randomized, double-blind, placebo-controlled, crossover, single-site inpatient clinical study was conducted at the National Institute of Mental Health to assess the efficacy and safety of a 3-week course of diazoxide (200-400 mg daily, twice a day) versus a 3-week course of placebo in 6 participants with treatment-refractory major depressive disorder...
March 29, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29487402/ketamine-has-distinct-electrophysiological-and-behavioral-effects-in-depressed-and-healthy-subjects
#3
Allison C Nugent, Elizabeth D Ballard, Todd D Gould, Lawrence T Park, Ruin Moaddel, Nancy E Brutsche, Carlos A Zarate
Ketamine's mechanism of action was assessed using gamma power from magnetoencephalography (MEG) as a proxy measure for homeostatic balance in 35 unmedicated subjects with major depressive disorder (MDD) and 25 healthy controls enrolled in a double-blind, placebo-controlled, randomized cross-over trial of 0.5 mg/kg ketamine. MDD subjects showed significant improvements in depressive symptoms, and healthy control subjects exhibited modest but significant increases in depressive symptoms for up to 1 day after ketamine administration...
February 27, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29330134/a-supplementary-functional-connectivity-microstate-attached-to-the-default-mode-network-in-depression-revealed-by-resting-state-magnetoencephalography
#4
Siqi Zhang, Shui Tian, Mohammad Ridwan Chattun, Hao Tang, Rui Yan, Kun Bi, Zhijian Yao, Qing Lu
Default mode network (DMN) has discernable involvement in the representation of negative, self-referential information in depression. Both increased and decreased resting-state functional connectivity between the anterior and posterior DMN have been observed in depression. These conflicting connectivity differences necessitated further exploration of the resting-state DMN dysfunction in depression. Hence, we investigated the time-varying dynamic interactions within the DMN via functional connectivity microstates in a sub-second level...
April 20, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29316987/diet-nutrition-and-the-ageing-brain-current-evidence-and-new-directions
#5
Katie Moore, Catherine F Hughes, Mary Ward, Leane Hoey, Helene McNulty
Globally populations are ageing. By 2050, it is estimated that there will be two billion people aged 60 years or over, of which 131 million are projected to be affected by dementia, while depression is predicted to be the second leading cause of disability worldwide by 2020. Preventing or delaying the onset of these disorders should therefore be a public health priority. There is some evidence linking certain dietary patterns, particularly the Mediterranean diet, with a reduced risk of dementia and depression...
January 10, 2018: Proceedings of the Nutrition Society
https://www.readbyqxmd.com/read/29167518/encoding-of-menstrual-pain-experience-with-theta-oscillations-in-women-with-primary-dysmenorrhea
#6
Pin-Shiuan Lee, Intan Low, Yong-Sheng Chen, Cheng-Hao Tu, Hsiang-Tai Chao, Jen-Chuen Hsieh, Li-Fen Chen
Theta oscillation (4-7 Hz) is well documented for its association with neural processes of memory. Pronounced increase of theta activity is commonly observed in patients with chronic neurogenic pain. However, its association with encoding of pain experience in patients with chronic pain is still unclear. The goal of the present study is to investigate the theta encoding of sensory and emotional information of long-term menstrual pain in women with primary dysmenorrhea (PDM). Forty-six young women with PDM and 46 age-matched control subjects underwent resting-state magnetoencephalography study during menstrual and periovulatory phases...
November 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28859565/neuroplasticity-and-the-brain-connectome-what-can-jean-talairach-s-reflections-bring-to-modern-psychosurgery
#7
Pierre Bourdillon, Caroline Apra, Marc Lévêque, Fabien Vinckier
Contrary to common psychosurgical practice in the 1950s, Dr. Jean Talairach had the intuition, based on clinical experience, that the brain connectome and neuroplasticity had a role to play in psychosurgery. Due to the remarkable progress of pharmacology at that time and to the technical limits of neurosurgery, these concepts were not put into practice. Currently, these concepts are being confirmed by modern techniques such as neuroimaging and computational neurosciences, and could pave the way for therapeutic innovation in psychiatry...
September 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28505586/oscillatory-magnetic-brain-activity-is-related-to-dissociative-symptoms-and-childhood-adversities-a-study-in-women-with-multiple-trauma
#8
I Schalinski, J K Moran, T Elbert, V Reindl, C Wienbruch
BACKGROUND: Individuals with trauma-related disorders are complex and heterogeneous; part of this complexity derives from additional psychopathology like dissociation as well as environmental adversities such as traumatic stress, experienced throughout the lifespan. Understanding the neurophysiological abnormalities in Post-traumatic stress disorder (PTSD) requires a simultaneous consideration of these factors. METHODS: Resting state magnetoencephalography (MEG) recordings were obtained from 41 women with PTSD and comorbid depressive symptoms, and 16 healthy women...
May 8, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28369363/noninvasive-stimulation-of-the-ventromedial-prefrontal-cortex-enhances-pleasant-scene-processing
#9
Markus Junghofer, Constantin Winker, Maimu A Rehbein, Dean Sabatinelli
Depressive patients typically show biased attention towards unpleasant and away from pleasant emotional material. Imaging studies suggest that dysfunctions in a distributed neural network, including the ventromedial prefrontal cortex (vmPFC), are associated with this processing bias. Accordingly, changes in vmPFC activation should mediate changes in processing of emotional stimuli. Here, we investigated the effect of inhibitory and excitatory transcranial direct current stimulation (tDCS) of the vmPFC on emotional scene processing in two within-subject experiments using functional magnetic resonance imaging (fMRI) and magnetoencephalography (MEG)...
June 1, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28367127/alterations-of-intrinsic-brain-connectivity-patterns-in-depression-and-bipolar-disorders-a-critical-assessment-of-magnetoencephalography-based-evidence
#10
REVIEW
Golnoush Alamian, Ana-Sofía Hincapié, Etienne Combrisson, Thomas Thiery, Véronique Martel, Dmitrii Althukov, Karim Jerbi
Despite being the object of a thriving field of clinical research, the investigation of intrinsic brain network alterations in psychiatric illnesses is still in its early days. Because the pathological alterations are predominantly probed using functional magnetic resonance imaging (fMRI), many questions about the electrophysiological bases of resting-state alterations in psychiatric disorders, particularly among mood disorder patients, remain unanswered. Alongside important research using electroencephalography (EEG), the specific recent contributions and future promise of magnetoencephalography (MEG) in this field are not fully recognized and valued...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28340449/right-hemisphere-pitch-mismatch-negativity-reduction-in-patients-with-major-depression-an-meg-study
#11
Noriaki Hirakawa, Yoji Hirano, Itta Nakamura, Shogo Hirano, Jinya Sato, Naoya Oribe, Takefumi Ueno, Shigenobu Kanba, Toshiaki Onitsuka
BACKGROUND: The mismatch negativity (MMN) component of the event-related potential and its magnetic counterpart, the MMNm, are generated by a mismatch between the physical features of a deviant stimulus and a neuronal sensory-memory trace produced by repetitive standard stimuli. Deficits in the MMN/MMNm have been reported in patients with major depression; however, the results are inconsistent. The present study investigated the pitch-MMNm in patients with major depression using whole-head 306-channel magnetoencephalography (MEG)...
June 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27993224/maternal-depression-across-the-first-years-of-life-impacts-the-neural-basis-of-empathy-in-preadolescence
#12
Maayan Pratt, Abraham Goldstein, Jonathan Levy, Ruth Feldman
OBJECTIVE: Exposure to maternal depression across the first years of life markedly increases children's susceptibility to psychopathology, yet no study has tested its effects on the maturation of children's social brain. METHOD: Using a birth cohort of mothers with no contextual risk (N = 1,983), families were followed at 7 time points from birth to 11 years and repeatedly assessed for maternal depression across the first 6 years to form 2 cohorts: mothers continuously depressed from birth to 6 years and controls without depression...
January 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/27524960/longitudinal-changes-in-depressive-circuitry-in-response-to-neuromodulation-therapy
#13
Yagna Pathak, Oludamilola Salami, Sylvain Baillet, Zhimin Li, Christopher R Butson
BACKGROUND: Major depressive disorder (MDD) is a public health problem worldwide. There is increasing interest in using non-invasive therapies such as repetitive transcranial magnetic stimulation (rTMS) to treat MDD. However, the changes induced by rTMS on neural circuits remain poorly characterized. The present study aims to test whether the brain regions previously targeted by deep brain stimulation (DBS) in the treatment of MDD respond to rTMS, and whether functional connectivity (FC) measures can predict clinical response...
2016: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/27441243/threatening-faces-induce-fear-circuitry-hypersynchrony-in-soldiers-with-post-traumatic-stress-disorder
#14
Benjamin T Dunkley, Elizabeth W Pang, Paul A Sedge, Rakesh Jetly, Sam M Doesburg, Margot J Taylor
BACKGROUND: Post-traumatic stress disorder (PTSD) is associated with atypical responses to emotional face stimuli with preferential processing given to threat-related facial expressions via hyperactive amygdalae disengaged from medial prefrontal modulation. METHOD: We examined implicit emotional face perception in soldiers with (n = 20) and without (n = 25) PTSD using magnetoencephalography to define spatiotemporal network interactions, and a subsequent region-of-interest analysis to characterize the network role of the right amygdala and medial prefrontal cortex in threatening face perception...
January 2016: Heliyon
https://www.readbyqxmd.com/read/27362845/preliminary-differences-in-resting-state-meg-functional-connectivity-pre-and-post-ketamine-in-major-depressive-disorder
#15
Allison C Nugent, Stephen E Robinson, Richard Coppola, Carlos A Zarate
Functional neuroimaging techniques including magnetoencephalography (MEG) have demonstrated that the brain is organized into networks displaying correlated activity. Group connectivity differences between healthy controls and participants with major depressive disorder (MDD) can be detected using temporal independent components analysis (ICA) on beta-bandpass filtered Hilbert envelope MEG data. However, the response of these networks to treatment is unknown. Ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, exerts rapid antidepressant effects...
August 30, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27331780/disconnecting-consciousness-is-there-a-common-anesthetic-end-point
#16
REVIEW
Anthony G Hudetz, George A Mashour
A quest for a systems-level neuroscientific basis of anesthetic-induced loss and return of consciousness has been in the forefront of research for the past 2 decades. Recent advances toward the discovery of underlying mechanisms have been achieved using experimental electrophysiology, multichannel electroencephalography, magnetoencephalography, and functional magnetic resonance imaging. By the careful dosing of various volatile and IV anesthetic agents to the level of behavioral unresponsiveness, both specific and common changes in functional and effective connectivity across large-scale brain networks have been discovered and interpreted in the context of how the synthesis of neural information might be affected during anesthesia...
November 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27199669/tacs-phase-locking-of-frontal-midline-theta-oscillations-disrupts-working-memory-performance
#17
Bankim S Chander, Matthias Witkowski, Christoph Braun, Stephen E Robinson, Jan Born, Leonardo G Cohen, Niels Birbaumer, Surjo R Soekadar
BACKGROUND: Frontal midline theta (FMT) oscillations (4-8 Hz) are strongly related to cognitive and executive control during mental tasks such as memory processing, arithmetic problem solving or sustained attention. While maintenance of temporal order information during a working memory (WM) task was recently linked to FMT phase, a positive correlation between FMT power, WM demand and WM performance was shown. However, the relationship between these measures is not well understood, and it is unknown whether purposeful FMT phase manipulation during a WM task impacts FMT power and WM performance...
2016: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/26922827/impact-of-electroconvulsive-therapy-on-magnetoencephalographic-correlates-of-dysfunctional-emotional-processing-in-major-depression
#18
Peter Zwanzger, Anna Luisa Klahn, Volker Arolt, Tillmann Ruland, Maxim Zavorotnyy, Johannes Sälzer, Katharina Domschke, Markus Junghöfer
In major depressive disorder (MDD), electrophysiological and imaging studies provide evidence for a reduced neural activity in parietal and dorsolateral prefrontal regions. In the present study, neural correlates and temporal dynamics of visual affective perception have been investigated in patients with unipolar depression in a pre/post treatment design using magnetoencephalography (MEG). Nineteen in-patients and 19 balanced healthy controls passed MEG measurement while passively viewing pleasant, unpleasant and neutral pictures...
April 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/26841800/psychedelics
#19
REVIEW
David E Nichols
Psychedelics (serotonergic hallucinogens) are powerful psychoactive substances that alter perception and mood and affect numerous cognitive processes. They are generally considered physiologically safe and do not lead to dependence or addiction. Their origin predates written history, and they were employed by early cultures in many sociocultural and ritual contexts. After the virtually contemporaneous discovery of (5R,8R)-(+)-lysergic acid-N,N-diethylamide (LSD)-25 and the identification of serotonin in the brain, early research focused intensively on the possibility that LSD and other psychedelics had a serotonergic basis for their action...
April 2016: Pharmacological Reviews
https://www.readbyqxmd.com/read/26655124/dynamic-functional-structural-coupling-within-acute-functional-state-change-phases-evidence-from-a-depression-recognition-study
#20
Kun Bi, Lingling Hua, Maobin Wei, Jiaolong Qin, Qing Lu, Zhijian Yao
BACKGROUND: Dynamic functional-structural connectivity (FC-SC) coupling might reflect the flexibility by which SC relates to functional connectivity (FC). However, during the dynamic acute state change phases of FC, the relationship between FC and SC may be distinctive and embody the abnormality inherent in depression. This study investigated the depression-related inter-network FC-SC coupling within particular dynamic acute state change phases of FC. METHODS: Magnetoencephalography (MEG) and diffusion tensor imaging (DTI) data were collected from 26 depressive patients (13 women) and 26 age-matched controls (13 women)...
February 2016: Journal of Affective Disorders
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