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Delayed ejaculation

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https://www.readbyqxmd.com/read/28807505/delayed-ejaculation-and-associated-complaints-relationship-to-ejaculation-times-and-serum-testosterone-levels
#1
Abraham Morgentaler, Paula Polzer, Stanley Althof, Alexander Bolyakov, Craig Donatucci, Xiao Ni, Ankur B Patel, Shehzad Basaria
BACKGROUND: Although delayed ejaculation (DE) is typically characterized as a persistently longer than anticipated or desired time to ejaculation (or orgasm) during sexual activity, a timing-based definition of DE and its association with serum testosterone has not been established in a large cohort. AIM: To examine in an observational study estimated intravaginal ejaculatory latency time (IELT) and masturbatory ejaculation latency time (MELT) in men self-reporting DE, assess the association of IELT and MELT with serum testosterone levels, and determine whether correlation with demographic and sexual parameters exist...
August 11, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28679197/total-phallic-reconstruction-after-penile-amputation-for-donkey-bite-case-report-and-review-of-the-literature
#2
Francesco De Luca, Giulio Garaffa, Angela Maurizi, Emy Manzi, Carlo De Dominicis, David Ralph
There are very few reported cases of traumatic amputation of the male genitalia due to animal bite. The management involves thorough washout of the wounds, debridement, antibiotic prophylaxis, tetanus and rabies immunization followed by immediate reconstruction or primary wound closure with delayed reconstruction, when immediate reconstruction is not feasible. When immediate reconstruction is not feasible, long-term good functional and cosmetic results are still possible in the majority of cases by performing total phallic reconstruction...
June 30, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28630352/structural-complexity-and-molecular-heterogeneity-of-a-butterfly-ejaculate-reflect-a-complex-history-of-selection
#3
Camille Meslin, Tamara S Cherwin, Melissa S Plakke, Brandon S Small, Breanna J Goetz, Nathan I Morehouse, Nathan L Clark
Male ejaculates are often structurally complex, and this complexity is likely to influence key reproductive interactions between males and females. However, despite its potential evolutionary significance, the molecular underpinnings of ejaculate structural complexity have received little empirical attention. To address this knowledge gap, we sought to understand the biochemical and functional properties of the structurally complex ejaculates of Pieris rapae butterflies. Males in this species produce large ejaculates called spermatophores composed of an outer envelope, an inner matrix, and a bolus of sperm...
July 3, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28540176/the-effect-of-8-oh-dpat-and-dapoxetine-on-gene-expression-in-the-brain-of-male-rats-during-ejaculation
#4
Xijun Qin, Xiaojun Ma, Dongping Tu, Zuliang Luo, Jie Huang, Changming Mo
The 5-HT1A receptor agonist 8-hydroxy-2-[di-n-propylamino] tetralin (8-OH-DPAT) promotes ejaculation of male rats, whereas dapoxetine delays this process. However, the gene expression profile of the brain at ejaculation following administrationof these two compounds has not been fully elucidated. In the present study, a transcriptomic BodyMap was generated by conducting mRNA-Seq on brain samples of male Sprague-Dawley rats. The study included four groups: pre-copulatory control (CK) group, ejaculation (EJ) group, 0...
May 2017: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/28501545/betamethasone-causes-intergenerational-reproductive-impairment-in-male-rats
#5
Cibele Dos Santos Borges, Taina Louise Pacheco, Katiussia Pinho da Silva, Fábio Henrique Fernandes, Mary Gregory, André Sampaio Pupo, Daisy Maria F Salvadori, Daniel G Cyr, Wilma De G Kempinas
Prenatal betamethasone (BM) exposure in rats negatively impacts sperm quality and male fertility. Studies have shown that BM can cause multi-generational effects on the pituitary-adrenal-axis of rats. The objective of this study was to assess the reproductive development and fertility of male rats (F2) whose fathers (F1) were exposed to BM (0.1mg/kg) on gestational days 12, 13, 18 and 19. In F2 rats, there was a significant reduction in body weights of the BM-treated group at PND 1 as well as delayed onset of puberty, and decreases in FSH levels, Leydig cell volume, sperm number and motility, seminal vesicle contractility and ejaculated volume...
May 10, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28474611/patient-reported-ejaculatory-function-and-satisfaction-in-men-with-lower-urinary-tract-symptoms-benign-prostatic-hyperplasia
#6
Min Chul Cho, Jung Kwon Kim, Sang Hoon Song, Sung Yong Cho, Sang Wook Lee, Soo Woong Kim, Jae-Seung Paick
This study aimed to investigate perceived ejaculatory function/satisfaction before treatment for lower urinary tract symptoms (LUTS)/benign prostatic hyperplasia (BPH) and to identify associations between specific categories of ejaculatory dysfunctions (EjDs) and LUTS. A total of 1574 treatment-naïve men with LUTS/BPH were included in this study. All patients underwent routine evaluation for LUTS/BPH including the International Index of Erectile Function and a 5-item questionnaire developed to assess ejaculatory volume/force/pain/satisfaction/latency time...
May 2, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28465683/chronic-administration-of-tadalafil-improves-the-symptoms-of-patients-with-amicrobic-magi-an-open-study
#7
Sandro La Vignera, Rosita A Condorelli, Laura M Mongioi, Aldo E Calogero
Aim of this study was to evaluate the effects of pharmacological treatment with Tadalafil 5 mg daily on symptoms and quality of sperm parameters in selected patients with amicrobic MAGI (male accessory gland inflammation). 120 patients with amicrobic MAGI (mean age 27.0 ± 6.0 years) with mild-moderate ED (erectile dysfunction) according to IIEF-5 (International Index of Erectile Function 5 Items) scores underwent pharmacological treatment with Tadalafil 5 mg daily for six months. Before and after treatment these patients were evaluated through IIEF-5, semen analysis (according to WHO Criteria, 2010), SI-MAGI (Structured Interview about Male Accessory Gland Inflammation), and ultrasound evaluation...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28408390/lidocaine-prilocaine-spray-for-premature-ejaculation
#8
(no author information available yet)
Although premature ejaculation is the most common ejaculation problem, it is poorly understood and currently has no standard definition.(1) Typically, it involves reduced time to ejaculation, inability to control or delay ejaculation and associated distress.(1-5) Treatments that have been assessed include psychosexual counselling, antidepressants (e.g. selective serotonin reuptake inhibitors), phosphodiesterase type-5 inhibitors, tramadol and topical anaesthetic agents (e.g. lidocaine/prilocaine cream). A new formulation (cutaneous spray) of lidocaine/prilocaine (Fortacin-Plethora Solutions Ltd...
April 2017: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/28341756/distress-disease-desire-perspectives-on-the-medicalisation-of-premature-ejaculation
#9
Ylva Söderfeldt, Adam Droppe, Tim Ohnhäuser
The discovery that certain selective serotonin reuptake inhibitors delay ejaculation and the later development and approval of dapoxetine as an on-demand treatment option has led to a dramatic increase in medical interest in premature ejaculation. This paper analyses the diagnostic criteria and the discussion within the medical community about suitable treatments against the backdrop of theories of science, sex and gender. Our conclusion is that the diagnosis itself and the suggested treatments contribute to normative models of sexual conduct and therefore reinforce the norms that cause patients' distress over ejaculating 'too soon'...
March 23, 2017: Journal of Medical Ethics
https://www.readbyqxmd.com/read/28261848/impact-of-physical-activity-on-patient-self-reported-outcomes-of-lifelong-premature-ejaculation-patients-results-of-a-prospective-randomised-sham-controlled-trial
#10
M F Kilinc, Y Aydogmus, Y Yildiz, O G Doluoglu
Previous studies have investigated whether physical activity increases serotonin hormone levels. Serotonin receptor dysfunction is one of the frequently accused factors of premature ejaculation (PE). Nevertheless, no studies up to date have demonstrated that the association between physical activity and premature ejaculation. We aimed to investigate the relationship between physical activity and PE and determine whether moderate physical activity might delay ejaculation time or be an alternative treatment for PE...
March 6, 2017: Andrologia
https://www.readbyqxmd.com/read/28159430/-jamaican-stone-a-potentially-lethal-remedy-for-delaying-ejaculation
#11
Belén Díaz-Antón, Guillermo Alonso-Deniz, Jose Luis Perez-Vela, Javier Molina-Martín de Nicolás, Belen Rubio-Alonso, Alfonso Jurado-Román, Ana Miguel-Gutierrez, Roberto Martin-Asenjo
Poisoning by ingestion of 'Jamaican Stone', a kind of cardioactive steroid, is extremely rare. However, mortality is very high. For this reason, when it occurs, an early and accurate diagnosis represents a critical challenge for clinicians. We present an unusual case of electrical storm caused by this substance.
February 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/28124112/is-there-room-for-behavioral-and-modifiable-health-related-targets-in-the-lower-urinary-tract-symptoms-scenario
#12
Osamu Ikari, Brunno C F Sanches, João Carlos Cardoso Alonso, Fabiano A Simões, Ronald F Rejowski, Walker Wendel Laranja, Leonardo O Reis
PURPOSE: To better understand potential modifiable risk factors guiding preventive interventions against lower urinary tract symptoms (LUTS). METHODS: A prospective cross-sectional study, including healthy men aged 40-70 years under routine urological evaluation, measured the strength of association between the International Prostate Symptom Score (IPSS) and socio-demographic, lifestyle, and health-related factors using logistic and linear regression adjusted for confounding factors...
January 25, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28041925/complementary-and-alternative-medicine-for-management-of-premature-ejaculation-a-systematic-review
#13
REVIEW
Katy Cooper, Marrissa Martyn-St James, Eva Kaltenthaler, Kath Dickinson, Anna Cantrell, Shijie Ren, Kevan Wylie, Leila Frodsham, Catherine Hood
INTRODUCTION: Premature ejaculation (PE) is defined as ejaculation within 1 minute (lifelong PE) or 3 minutes (acquired PE), inability to delay ejaculation, and negative personal consequences. Management includes behavioral and pharmacologic approaches. AIM: To systematically review effectiveness, safety, and robustness of evidence for complementary and alternative medicine in managing PE. METHODS: Nine databases including Medline were searched through September 2015...
March 2017: Sexual Medicine
https://www.readbyqxmd.com/read/27905874/are-sexually-selected-traits-affected-by-a-poor-environment-early-in-life
#14
Regina Vega-Trejo, Michael D Jennions, Megan L Head
BACKGROUND: Challenging conditions experienced early in life, such as a restricted diet, can detrimentally affect key life-history traits. Individuals can reduce these costs by delaying their sexual maturation, albeit at the price of the later onset of breeding, to eventually reach the same adult size as individuals that grow up in a benevolent environment. Delayed maturation can, however, still lead to other detrimental morphological and physiological changes that become apparent later in adulthood (e...
December 1, 2016: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/27860425/centrally-mediated-ejaculatory-response-via-sympathetic-outflow-in-rats-role-of-n-methyl-d-aspartic-acid-receptors-in-paraventricular-nucleus
#15
J-D Xia, J Chen, H-J Sun, L-H Zhou, G-Q Zhu, Y Chen, Y-T Dai
Ejaculation is mediated by a spinal generator, which integrates inputs related to the sexual activity and coordinates sympathetic, parasympathetic, and motor outflow. Previous clinical studies indicate that primary premature ejaculation is related to the hyperactivity of the sympathetic nervous system. In this study, we explored the roles of N-methyl-D-aspartic acid (NMDA) receptors in paraventricular nucleus of the hypothalamus (PVN) on ejaculatory responses and its potential mechanism in the rats. We found that microinjection of 0...
January 2017: Andrology
https://www.readbyqxmd.com/read/27822042/efficacy-and-safety-of-multiple-doses-of-levomilnacipran-extended-release-for-the-treatment-of-major-depressive-disorder
#16
Qunlian Huang, Xiaoyan Zhong, Ye Yun, Bin Yu, Yilan Huang
OBJECTIVE: The aim of this meta-analysis was to evaluate the efficacy and safety of levomilnacipran extended-release (ER) in the treatment of major depressive disorder (MDD). METHODS: Randomized controlled trials were searched by electronic databases. Unpublished data were also searched by the relevant websites. Weighted mean difference (WMD) and risk ratio (RR) with 95% confidence interval (CI) were calculated and pooled using fixed-effects model or random-effects model...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27729995/effectiveness-of-on-demand-silodosin-in-the-treatment-of-premature-ejaculation-in-patients-dissatisfied-with-dapoxetine-a-randomized-control-study
#17
Gajanan S Bhat, Anuradha Shastry
INTRODUCTION: Premature ejaculation is a common sexual disorder, which is usually underreported. Multiple treatment methodologies are in use due to the absence of an effective, universally acceptable treatment modality. The most common drug used is dapoxetine, which has adverse effects limiting its long-term use. Hence, we decided to evaluate the effectiveness of 'on demand' silidosin 4 mg in patients with premature ejaculation, who were dissatisfied with dapoxetine 30 mg. MATERIAL AND METHODS: The study included 64 patients who reported premature ejaculation who were unhappy with the treatment with 'on demand' dapoxetine 30 mg, either due to its adverse effects or because of its overall inefficacy...
2016: Central European Journal of Urology
https://www.readbyqxmd.com/read/27679962/effects-of-paroxetine-on-intravaginal-ejaculatory-latency-time-in-egyptian-patients-with-lifelong-premature-ejaculation-as-a-function-of-serotonin-transporter-polymorphism
#18
RANDOMIZED CONTROLLED TRIAL
A M Salem, I I Kamel, L A Rashed, S F GamalEl Din
Premature ejaculation (PE) is a common ejaculatory complaint. The estimated rates among Turkish men reached 20%, although the severest type of PE (lifelong PE) usually does not exceed 2.3%. This could be seen in line with two survey studies involving five nations. They revealed that 2.5% of men had an intravaginal ejaculation latency time of <1 min and 6% of <2 min. Rapid ejaculation may be treated pharmacologically with a variety of different medications that act either centrally or locally to delay ejaculation and subsequent orgasm...
January 2017: International Journal of Impotence Research
https://www.readbyqxmd.com/read/27679830/kallmann-syndrome-and-deafness-an-uncommon-combination-a-case-report-and-a-literature-review
#19
Nader Salama
BACKGROUND: Kallmann syndrome (Kal S) is an isolated form of hypogonadotrophic hypogonadism in combination with a defect in smell sensation. Depending on the genetic form of the disease, a number of non-reproductive, non-olfactory abnormalities may also be existent. In the present report, we describe a male with Kal S associated with hearing loss, and the successful treatment of his sexual and reproductive defects. CASE: A 23-year-old Caucasian man presented with a lifelong lack of erection and ejaculation...
August 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/27676982/sexual-disorders-in-stroke-patients-compared-with-control-subjects-in-benin-a-prospective-study
#20
Herman Azanmasso, Étienne Alagnidé, Joycia G Hounmenou, Didier Niama Natta, Toussaint G Kpadonou
OBJECTIVE: The genito-sexual disorders can be caused by stroke. These disorders often are silent even if they are at the heart of patient concerns. The objective was to study the sexual dysfunction in patients with stroke compared to control subjects. MATERIAL/PATIENTS AND METHODS: We did a prospective descriptive analytical cross-sectional study in the department of functional rehabilitation of National university hospital center of Cotonou CNHU HKM. This study involved 134 subjects including 67 stroke patients dating back at least 6 months and 67 controls matched to cases by age and sex...
September 2016: Annals of Physical and Rehabilitation Medicine
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