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acute otitis media

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https://www.readbyqxmd.com/read/28303055/inner-ear-disturbances-related-to-middle-ear-inflammation
#1
REVIEW
Michihiko Sone
The inner and middle ear are connected mainly through round and oval windows, and inflammation in the middle ear cavity can spread into the inner ear, which might induce a disturbance. In cases with intractable otitis media, attention should also be paid to symptoms related to the inner ear. In this paper, middle ear inflammation and related inner ear disturbances are reviewed with a focus on representative middle ear diseases (such as acute otitis media, chronic otitis media, otitis media with anti-neutrophil cytoplasmic antibody-associated vasculitis, eosinophilic otitis media, cholesteatoma with labyrinthine fistula, and reflux-related otitis media)...
February 2017: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28289114/parents-expectations-and-experiences-of-antibiotics-for-acute-respiratory-infections-in-primary-care
#2
Peter D Coxeter, Chris Del Mar, Tammy C Hoffmann
PURPOSE: Primary care visits for children with acute respiratory infections frequently result in antibiotic prescriptions, although antibiotics have limited benefits for common acute respiratory infections and can cause harms, including antibiotic resistance. Parental demands are often blamed for antibiotic prescription. We aimed to explore parents' beliefs about antibiotic necessity, quantify their expectations of antibiotic benefit, and report experiences of other management options and exposure to and preferences for shared decision making...
March 2017: Annals of Family Medicine
https://www.readbyqxmd.com/read/28283791/balloon-eustachian-tuboplasty-in-children
#3
A Leichtle, D Hollfelder, B Wollenberg, K-L Bruchhage
Endonasal ballon dilatation of the Eustachian tube (BET) is a promising treatment for Eustachian tube dysfunction with encouraging results over the last years in adults. In addition, in children, single studies demonstrated promising results, but revealed the necessity for broader and additional studies. Our retrospective analysis presents outcomes with BET in children with chronic obstructive dysfunction of the Eustachian tube, showing resistance to the conventional therapy after adenotomy with paracentesis or grommets (ventilation tubes)...
March 10, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28279802/prevention-of-influenza-virus-induced-bacterial-superinfection-by-standardized-echinacea-purpurea-via-regulation-of-surface-receptor-expression-in-human-bronchial-epithelial-cells
#4
Vimalanathan Selvarani, Schoop Roland, Suter Andy, Hudson James
Viral infections may predispose the airways to secondary bacterial infections that can lead to unfavorable progression of principally self-limiting illnesses. Such complicated respiratory infections include pneumonia, bronchitis, sinusitis, acute otitis media, and sepsis, which cause high morbidity and lethality. Some of the pathogenic consequences of viral infections, like the expression of bacterial adhesion receptors and the disturbance of physical barrier integrity due to inflammation, may create permissive conditions for co-infections...
March 6, 2017: Virus Research
https://www.readbyqxmd.com/read/28279741/enhanced-non-invasive-trans-tympanic-delivery-of-ciprofloxacin-through-encapsulation-into-nano-spanlastic-vesicles-fabrication-in-vitro-characterization-and-comparative-ex-vivo-permeation-studies
#5
Abdulaziz Mohsen Al-Mahallawi, Omneya Mohammed Khowessah, Raguia Ali Shoukri
The aim of this research was to encapsulate ciprofloxacin, a broad spectrum fluoroquinolone antibiotic, into Span 60 based nano-elastic vesicles, nano-spanlastics, for accomplishing improved non invasive trans-tympanic delivery, providing means for ototopical treatment of acute otitis media (AOM). To achieve this purpose, ciprofloxacin-loaded nano-spanlastics were prepared by thin film hydration (TFH) technique, using several non-ionic edge activators (EAs) according to full factorial design (3(2)). The investigation of the effect of formulation variables on nano-spanlastic characteristics and selection of the optimum formula were performed using Design-Expert(®) software...
March 7, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28279564/pneumococcal-carriage-and-serotype-variation-before-and-after-introduction-of-pneumococcal-conjugate-vaccines-in-patients-with-acute-otitis-media-in-switzerland
#6
Aurélie Allemann, Pascal M Frey, Silvio D Brugger, Markus Hilty
BACKGROUND: Acute otitis media (AOM) is an important cause for antibiotic prescription within the paediatric population and Streptococcus pneumoniae is a major pathogen associated with AOM episodes. This study aimed at analysing the influence of the heptavalent and 13-valent pneumococcal conjugate vaccines (PCV7 and PCV13) on pneumococcal carriage and serotype distribution in AOM. METHODS: Nasopharyngeal swabs (NPS) and middle ear fluid (MEF) were collected within a Swiss surveillance study of outpatients from all ages with AOM between 2004 and 2015, covering three vaccination eras (pre-PCV7, PCV7 and PCV13)...
March 6, 2017: Vaccine
https://www.readbyqxmd.com/read/28277413/community-primary-care-provider-preferences-for-emergency-department-follow-up-recommendations-a-regional-study
#7
Marissa A Hendrickson, Eta Obeya, Andrew R Wey, Philippe R Gaillard
BACKGROUND: Children who present to emergency departments (EDs) for care are frequently advised to follow up with their primary care providers (PCPs) after discharge; little is known about whether PCPs agree that follow-up advised by EDs is appropriate for their patients. OBJECTIVES: The aims of this study were to determine PCP preferences for follow-up recommendations given to their pediatric patients at the time of ED visits and to compare these preferences to reported emergency medicine provider (EMP) practice...
March 9, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28277045/antibiotic-prescribing-in-relation-to-diagnoses-and-consultation-rates-in-belgium-the-netherlands-and-sweden-use-of-european-quality-indicators
#8
Mia Tyrstrup, Alike van der Velden, Sven Engstrom, Geert Goderis, Sigvard Molstad, Theo Verheij, Samuel Coenen, Niels Adriaenssens
OBJECTIVE: To assess the quality of antibiotic prescribing in primary care in Belgium, the Netherlands and Sweden using European disease-specific antibiotic prescribing quality indicators (APQI) and taking into account the threshold to consult and national guidelines. DESIGN: A retrospective observational database study. SETTING: Routine primary health care registration networks in Belgium, the Netherlands and Sweden. SUBJECTS: All consultations for one of seven acute infections [upper respiratory tract infection (URTI), sinusitis, tonsillitis, otitis media, bronchitis, pneumonia and cystitis] and the antibiotic prescriptions in 2012 corresponding to these diagnoses...
March 3, 2017: Scandinavian Journal of Primary Health Care
https://www.readbyqxmd.com/read/28258074/cost-effectiveness-of-watchful-waiting-in-acute-otitis-media
#9
Di Sun, T J McCarthy, Danica B Liberman
BACKGROUND: American Academy of Pediatrics guidelines for acute otitis media (AOM) allow for children meeting certain criteria to undergo watchful waiting (WW). The cost-effectiveness of this policy has not been evaluated in the United States. METHODS: A retrospective review of a random selection of 250 patients ≤18 years old with AOM in the emergency department of a tertiary care children's hospital was used to characterize current practice of AOM management...
March 3, 2017: Pediatrics
https://www.readbyqxmd.com/read/28257541/risk-factors-for-outpatient-use-of-antibiotics-in-children-with-acute-respiratory-illnesses
#10
Sophie R Zhao, Marie R Griffin, Barron L Patterson, Rachel L Mace, Dayna Wyatt, Yuwei Zhu, H Keipp Talbot
OBJECTIVES: Antibiotics for acute respiratory illness (ARI) constitute most pediatric medication use and contribute to the emergence of antimicrobial resistance. We investigated antibiotic prescription risk factors for ARI in pediatric clinics and clinical follow-up in individuals prescribed and not prescribed antibiotics. METHODS: In this observational study, we enrolled children ages 2 to 17 years old presenting with ARI with fever to two academic pediatric primary care outpatient clinics during influenza season 2013-2014...
March 2017: Southern Medical Journal
https://www.readbyqxmd.com/read/28252201/non-typeable-haemophilus-influenzae-infection-of-the-junbo-mouse
#11
Michael T Cheeseman, Derek W Hood
Acute otitis media, inflammation of the middle ear bulla, is the most common bacterial infection in children. For one of the principal otopathogens, non-typeable Haemophilus influenzae (NTHi), animal models allow us to investigate host-microbial interactions relevant to the onset and progression of infection and to study treatment of middle ear disease. We have established a robust model of NTHi middle ear infection in the Junbo mouse. Intranasal inoculation with NTHi produces high rates of bulla infection and high bacterial titers in bulla fluids; bacteria can also spread down the respiratory tract to the mouse lung...
March 2, 2017: Current Protocols in Mouse Biology
https://www.readbyqxmd.com/read/28244296/bacterial-species-and-antibiotic-sensitivity-in-korean-patients-diagnosed-with-acute-otitis-media-and-otitis-media-with-effusion
#12
Sang Hoon Kim, Eun Ju Jeon, Seok Min Hong, Chang Hoon Bae, Ho Yun Lee, Moo Kyun Park, Jae Yong Byun, Myung Gu Kim, Seung Geun Yeo
Changes over time in pathogens and their antibiotic sensitivity resulting from the recent overuse and misuse of antibiotics in otitis media (OM) have complicated treatment. This study evaluated changes over 5 years in principal pathogens and their antibiotic sensitivity in patients in Korea diagnosed with acute OM (AOM) and OM with effusion (OME). The study population consisted of 683 patients who visited the outpatient department of otorhinolaryngology in 7 tertiary hospitals in Korea between January 2010 and May 2015 and were diagnosed with acute AOM or OME...
April 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28239580/facial-nerve-paralysis-in-acute-suppurative-otitis-media-management
#13
Sriranga Prasad, K V Vishwas, Swetha Pedaprolu, R Kavyashree
Facial paralysis is a rare complication of acute suppurative otitis media which requires early detection and appropriate care. We hereby report a case which we managed conservatively with good outcome. Following our experience and review of literature on the subject, antibiotic therapy and corticosteroid therapy, with or without myringotomy were found to be the first-line procedures. Surgery should be employed in case of acute or coalescent mastoiditis, suppurative complications and lack of clinical regression...
March 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28235386/characteristics-of-ci-children-with-complicated-middle-ear-infections
#14
Søren Hoberg, Christian Danstrup, Bjarke Laursen, Niels Krintel Petersen, Nichlas Udholm, Gintaras Audrius Kamarauskas, Therese Ovesen
OBJECTIVE: To describe cases of complicated middle ear infections in children with cochlear implants (CI), i.e., episodes of acute otitis media (AOM) and acute mastoiditis (AM), resulting in hospitalization. METHODS: A total of 206 children under 16 years (300 implantations) were implanted between 1 January 2008 and 31 December 2014 at the West Danish CI Center, Department of Otorhinolaryngology Head and Neck Surgery, Aarhus, Denmark. By means of two prospective local databases, episodes of AOM or AM and demographics were retrieved including biochemistry, microbiology, length of follow- up, and variable treatment modalities (intravenous (IV) antibiotics, revision mastoidectomy, and insertion of ventilation tubes)...
February 24, 2017: Cochlear Implants International
https://www.readbyqxmd.com/read/28188119/incidence-and-economic-burden-of-acute-otitis-media-in-children-aged-up-to-5years-in-three-middle-eastern-countries-and-pakistan-a-multinational-retrospective-observational-study
#15
Ghulam Mustafa, Amal Y Al Aidaroos, Idris S Al Abaidani, Kinga Meszaros, Kusuma Gopala, Mehmet Ceyhan, Mohamad Al-Tannir, Rodrigo DeAntonio, Shyam Bawikar, Johannes E Schmidt
Epidemiological data on acute otitis media (AOM), an infectious disease frequently affecting children, are lacking in some countries. This study was undertaken to assess the incidence of AOM in children ≤5years in Saudi Arabia, Oman, Pakistan, and Turkey, as well as the economic burden from a parent/caregiver perspective. Medical records of 4043 children (Saudi Arabia=1023, Oman=998, Pakistan=1022, Turkey=1000) were retrospectively reviewed and the incidence of AOM episodes calculated from suspected and confirmed cases...
February 7, 2017: Journal of Epidemiology and Global Health
https://www.readbyqxmd.com/read/28178138/etiology-of-acute-otitis-media-and-serotype-distribution-of-streptococcus-pneumoniae-and-haemophilus-influenzae-in-chilean-children-5-years-of-age
#16
Andres Rosenblut, Carla Napolitano, Angelica Pereira, Camilo Moreno, Devayani Kolhe, Alejandro Lepetic, Eduardo Ortega-Barria
The impact of bacterial conjugate vaccines on acute otitis media (AOM) is affected by several factors including population characteristics, bacterial etiology and vaccine conjugation method, carrier, and coverage. This study estimated the baseline etiology, distribution, and antibiotic susceptibility of bacterial serotypes that causes AOM in children aged <5 years in a public setting in Santiago, Chile.Children aged ≥3 months and <5 years referred to the physician for treatment of AOM episodes (with an onset of symptoms <72 h) were enrolled between September 2009 and September 2010...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28167007/sinuclean-nebules-treatment-in-children-suffering-from-otitis-media-with-effusion
#17
A Varricchio, A De Lucia, A M Varricchio, A Della Volpe, N Mansi, V Pastore, G Ciprandi
OBJECTIVE: Otitis media with effusion (OME) is an ear disorder defined by the presence of fluid in the middle ear without signs or symptoms of acute infection. The current randomized, double-blind, controlled study aimed to evaluate whether Sinuclean Nebules treatment, administered by nasal douche (Rinowash), could induce ear healing better than isotonic saline in children with OME. METHODS: The study was randomized, double-blind, and controlled. Group A (30 children) was treated with Sinuclean Nebules 45 and Group B (31 children) was treated with isotonic saline; both compounds were administered by nasal nebulization with Rinowash nasal douche twice/day in the morning and in the evening for 10 days, followed by a one-week suspension, and after by a second course as the first...
March 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28158735/antibiotic-prescribing-for-acute-otitis-media-and-acute-sinusitis-a-cross-sectional-analysis-of-the-recent-study-exploring-the-habits-of-early-career-doctors-in-family-practice
#18
Anthea Dallas, Mieke van Driel, Simon Morgan, Amanda Tapley, Kim Henderson, Chris Oldmeadow, Jean Ball, Andrew Davey, Katie Mulquiney, Joshua Davis, Neil Spike, Lawrie McArthur, Rebecca Stewart, Parker Magin
No abstract text is available yet for this article.
February 1, 2017: Family Practice
https://www.readbyqxmd.com/read/28157838/purification-and-characterization-of-micrornas-within-middle-ear-fluid-exosomes-implication-in-otitis-media-pathophysiology
#19
Stéphanie Val, Stephanie Jeong, Marian Poley, Anna Krueger, Gustavo Nino, Kristy Brown, Diego Preciado
BACKGROUND: Otitis Media (OM) is characterized by acute infection progressing to chronic middle ear effusion (MEE). Extracellular secretion of microRNAs (miRNAs) in exosomes is a newly discovered mechanism for cells exerting distant cell genetic regulation. Whether MEE contains exosomes with specific miRNAs is unknown. This study aimed to purify and characterize the exosomal and miRNA content of MEE. METHOD: MEEs were subjected to Exoquick exosomal purification and EXOCET exosomal quantification...
February 3, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28143785/correlation-of-higher-antibody-levels-to-pneumococcal-proteins-with-protection-from-pneumococcal-acute-otitis-media-but-not-protection-from-nasopharyngeal-colonization-in-young-children
#20
Q Xu, J R Casey, A Almudevar, M E Pichichero
OBJECTIVES: We previously found that nasopharyngeal (NP) colonization by Streptococcus pneumoniae elicits mucosal antibody responses to three protein vaccine candidates: pneumococcal histidine triad protein D (PhtD), pneumococcal choline-binding protein A (PcpA), and detoxified pneumolysin (PlyD1). Here we sought to determine if mucosal antibody levels to the proteins correlated with protection from acute otitis media (AOM) and NP colonization. METHODS: A total of 228 NP samples were prospectively collected from 100 healthy infants at 6-24 months of age...
January 28, 2017: Clinical Microbiology and Infection
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