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acute otitis media

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https://www.readbyqxmd.com/read/28188119/incidence-and-economic-burden-of-acute-otitis-media-in-children-aged-up-to-5years-in-three-middle-eastern-countries-and-pakistan-a-multinational-retrospective-observational-study
#1
Ghulam Mustafa, Amal Y Al Aidaroos, Idris S Al Abaidani, Kinga Meszaros, Kusuma Gopala, Mehmet Ceyhan, Mohamad Al-Tannir, Rodrigo DeAntonio, Shyam Bawikar, Johannes E Schmidt
Epidemiological data on acute otitis media (AOM), an infectious disease frequently affecting children, are lacking in some countries. This study was undertaken to assess the incidence of AOM in children ≤5years in Saudi Arabia, Oman, Pakistan, and Turkey, as well as the economic burden from a parent/caregiver perspective. Medical records of 4043 children (Saudi Arabia=1023, Oman=998, Pakistan=1022, Turkey=1000) were retrospectively reviewed and the incidence of AOM episodes calculated from suspected and confirmed cases...
February 7, 2017: Journal of Epidemiology and Global Health
https://www.readbyqxmd.com/read/28178138/etiology-of-acute-otitis-media-and-serotype-distribution-of-streptococcus-pneumoniae-and-haemophilus-influenzae-in-chilean-children-5-years-of-age
#2
Andres Rosenblut, Carla Napolitano, Angelica Pereira, Camilo Moreno, Devayani Kolhe, Alejandro Lepetic, Eduardo Ortega-Barria
The impact of bacterial conjugate vaccines on acute otitis media (AOM) is affected by several factors including population characteristics, bacterial etiology and vaccine conjugation method, carrier, and coverage. This study estimated the baseline etiology, distribution, and antibiotic susceptibility of bacterial serotypes that causes AOM in children aged <5 years in a public setting in Santiago, Chile.Children aged ≥3 months and <5 years referred to the physician for treatment of AOM episodes (with an onset of symptoms <72 h) were enrolled between September 2009 and September 2010...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28167007/sinuclean-nebules-treatment-in-children-suffering-from-otitis-media-with-effusion
#3
A Varricchio, A De Lucia, A M Varricchio, A Della Volpe, N Mansi, V Pastore, G Ciprandi
OBJECTIVE: Otitis media with effusion (OME) is an ear disorder defined by the presence of fluid in the middle ear without signs or symptoms of acute infection. The current randomized, double-blind, controlled study aimed to evaluate whether Sinuclean Nebules treatment, administered by nasal douche (Rinowash), could induce ear healing better than isotonic saline in children with OME. METHODS: The study was randomized, double-blind, and controlled. Group A (30 children) was treated with Sinuclean Nebules 45 and Group B (31 children) was treated with isotonic saline; both compounds were administered by nasal nebulization with Rinowash nasal douche twice/day in the morning and in the evening for 10 days, followed by a one-week suspension, and after by a second course as the first...
March 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28158735/antibiotic-prescribing-for-acute-otitis-media-and-acute-sinusitis-a-cross-sectional-analysis-of-the-recent-study-exploring-the-habits-of-early-career-doctors-in-family-practice
#4
Anthea Dallas, Mieke van Driel, Simon Morgan, Amanda Tapley, Kim Henderson, Chris Oldmeadow, Jean Ball, Andrew Davey, Katie Mulquiney, Joshua Davis, Neil Spike, Lawrie McArthur, Rebecca Stewart, Parker Magin
No abstract text is available yet for this article.
February 1, 2017: Family Practice
https://www.readbyqxmd.com/read/28157838/purification-and-characterization-of-micrornas-within-middle-ear-fluid-exosomes-implication-in-otitis-media-pathophysiology
#5
Stéphanie Val, Stephanie Jeong, Marian Poley, Anna Krueger, Gustavo Nino, Kristy Brown, Diego Preciado
BACKGROUND: Otitis Media (OM) is characterized by acute infection progressing to chronic middle ear effusion (MEE). Extracellular secretion of microRNAs (miRNAs) in exosomes is a newly discovered mechanism for cells exerting distant cell genetic regulation. Whether MEE contains exosomes with specific miRNAs is unknown. This study aimed to purify and characterize the exosomal and miRNA content of MEE. METHOD: MEEs were subjected to Exoquick exosomal purification and EXOCET exosomal quantification...
February 3, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28143785/correlation-of-higher-antibody-levels-to-pneumococcal-proteins-with-protection-from-pneumococcal-acute-otitis-media-but-not-protection-from-nasopharyngeal-colonization-in-young-children
#6
Qingfu Xu, Janet R Casey, Anthony Almudevar, Michael E Pichichero
OBJECTIVES: We previously found that nasopharyngeal (NP) colonization by Streptococcus pneumoniae (Spn) elicits mucosal antibody responses to three protein vaccine candidates: pneumococcal histidine triad protein D (PhtD), pneumococcal choline binding protein A (PcpA), and detoxified pneumolysin (PlyD1). Here we sought to determine if mucosal antibody levels to the proteins correlated with protection from acute otitis media (AOM) and NP colonization. METHODS: 228 NP samples were prospectively collected from 100 healthy infants at 6-24 months of age...
January 28, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28124644/differences-in-innate-immune-response-gene-regulation-in-the-middle-ear-of-children-who-are-otitis-prone-and-in-those-not-otitis-prone
#7
Ravinder Kaur, Janet Casey, Michael Pichichero
OBJECTIVE: Acute otitis media (AOM) causes an inflammatory response in the middle ear. We assessed differences in innate immune responses involved in bacterial defense at onset of AOM in children who were stringently defined as otitis prone (sOP) and children not otitis prone (NOP). STUDY DESIGN: Innate immune genes analysis from middle ear fluid (MEF) samples of children. METHODS: Genes of toll-like receptors (TLR), nod-like and retinoic acid-inducible gene-I-like receptors, downstream effectors important for inflammation and apoptosis, including cytokines and chemokines, were studied from MEF samples by using a real-time polymerase chain reaction array...
November 1, 2016: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/28122841/antibiotic-management-of-children-with-infectious-diseases-in-dutch-primary-care
#8
Anne R J Dekker, Theo J M Verheij, Alike W van der Velden
BACKGROUND: Childhood infections are common in general practice. Although clinical guidelines recommend restrictive antibiotic use for children, antibiotics are too often prescribed. OBJECTIVE: The aim of this study was to obtain insight in antibiotic prescribing for children related to clinical diagnoses. This is pivotal to define improvement strategies in the antibiotic management. METHODS: In this observational study, we used consultation data collected from 45 general practices in the Netherlands in 2012...
January 24, 2017: Family Practice
https://www.readbyqxmd.com/read/28122100/acute-bacterial-meningitis-caused-by-acute-otitis-media-in-adults-a-series-of-12-patients
#9
Daniel M Kaplan, Ofer Gluck, Mordechai Kraus, Youval Slovik, Hindy Juwad
We conducted a retrospective chart review to characterize the outcomes of 12 patients-9 men and 3 women, aged 21 to 79 years (mean: 49)-who had been treated at our tertiary care center for acute bacterial meningitis caused by acute otitis media (ABMAO). Fever was the most common presenting sign/symptom, observed in 8 patients, followed by otalgia, neck stiffness, headache, and confusion. An opaque and bulging tympanic membrane was observed in 8 patients. Cultures were positive for Streptococcus pneumoniae in the cerebrospinal fluid, ear, and blood in 7, 5, and 3 patients, respectively...
January 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28119402/a-national-pharmacoepidemiological-study-of-antibiotic-use-in-korean-paediatric-outpatients
#10
Yun-Kyoung Song, Nayoung Han, Myeong Gyu Kim, Hyeu-Jin Chang, Hyun Soon Sohn, Eunhee Ji, Jung Mi Oh
BACKGROUND: Information on the use of antibiotics in Eastern Asian children is limited. The objectives of this study were to evaluate in Korean paediatric outpatients (1) the nationwide pattern of prescribing antibiotics according to age group and medical institution and (2) the adherence of antibiotic use for acute respiratory tract infections to both national guidelines and European antibiotic prescribing quality indicators. METHOD: This population-based study used the national insurance reimbursement database for 2011...
January 24, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28114208/radiological-imaging-of-rare-intracranial-complications-secondary-to-otitis-media-and-mastoiditis
#11
Gülen Burakgazi, Hanifi Bayaroğullari, Fatma Öztürk, Cengiz Arli, Vicdan Köksaldi Motor, Rasim Yanmaz, Nesrin Atci
Acute otitis media used to cause fatal results because of its intracranial complications before the introduction of potent and effective antibiotics. After the introduction of antibiotics, complications have started to be observed more frequently as a result of chronic otitis media and especially in children. Because clinical findings changed and became indistinct, the diagnosis of otitis and mastoiditis has been made occasionally with imaging findings only after complications occurred. Multidetector computed tomography and magnetic resonance imaging are efficient and sufficient methods in the rapid diagnosis and should be immediately referred methods...
January 20, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28110050/prospective-evaluation-of-the-aetiology-of-acute-otitis-media-with-spontaneous-tympanic-membrane-perforation
#12
Paola Marchisio, Susanna Esposito, Marina Picca, Elena Baggi, Leonardo Terranova, Annalisa Orenti, Elia Biganzoli, Nicola Principi
OBJECTIVES: To evaluate the aetiologic role of the main bacterial pathogens associated with acute otitis media (AOM) in children with AOM and spontaneous tympanic membrane perforation (STMP). METHODS: Between May 1, 2015 and April 30, 2016, 177 children, 6 months to 7 years old, with AOM complicated by STMP within 12 h were prospectively enrolled. Middle ear fluid (MEF) was tested by real-time polymerase chain reaction for Streptococcus pneumoniae, nontypeable Haemophilus influenzae, Streptococcus pyogenes, Moraxella catarrhalis and Staphylococcus aureus...
January 18, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28109706/cost-effectiveness-of-13-valent-pneumococcal-conjugate-vaccination-in-mongolia
#13
Neisha Sundaram, Cynthia Chen, Joanne Yoong, Munkh-Erdene Luvsan, Kimberley Fox, Amarzaya Sarankhuu, Sophie La Vincente, Mark Jit
OBJECTIVE: The Ministry of Health (MOH), Mongolia, is considering introducing 13-valent pneumococcal conjugate vaccine (PCV13) in its national immunization programme to prevent the burden of disease caused by Streptococcus pneumoniae. This study evaluates the cost-effectiveness and budget impact of introducing PCV13 compared to no PCV vaccination in Mongolia. METHODS: The incremental cost-effectiveness ratio (ICER) of introducing PCV13 compared to no PCV vaccination was assessed using an age-stratified static multiple cohort model...
February 15, 2017: Vaccine
https://www.readbyqxmd.com/read/28103950/the-effects-of-ventilation-tubes-versus-no-ventilation-tubes-for-recurrent-acute-otitis-media-or-chronic-otitis-media-with-effusion-in-9-to-36%C3%A2-month-old-greenlandic-children-the-siutit-trial-study-protocol-for-a-randomized-controlled-trial
#14
Malene Nøhr Demant, Ramon Gordon Jensen, Janus Christian Jakobsen, Christian Gluud, Preben Homøe
BACKGROUND: The prevalence of otitis media in Greenlandic children is one of the highest in the world. International studies have shown that otitis-prone children may benefit from tubulation of the tympanic membrane. However, it is unknown whether these results can be applied to Greenlandic children and trials on the effects of ventilation tubes in high-risk populations have, to our knowledge, never been conducted. METHODS: The trial is an investigator-initiated, multicentre, randomized, blinded superiority trial of bilateral ventilation tube insertion versus treatment as usual (no tube) in Greenlandic children aged 9-36 months with chronic otitis media with effusion or recurrent acute otitis media...
January 19, 2017: Trials
https://www.readbyqxmd.com/read/28088130/vaccine-candidates-against-nontypeable-haemophilus-influenzae-a-review
#15
REVIEW
Ava Behrouzi, Farzam Vaziri, Fatemeh Rahimi-Jamnani, Parviz Afrough, Mohammad Rahbar, Fereshteh Satarian, Seyed Davar Siadat
Nonencapsulated, nontypeable Hemophilus influenzae (NTHi) remains an important cause of acute otitis and respiratory diseases in children and adults. NTHi bacteria are one of the major causes of respiratory tract infections, including acute otitis media, cystic fibrosis, and community-acquired pneumonia among children, especially in developing countries. The bacteria can also cause chronic diseases such as chronic bronchitis and chronic obstructive pulmonary disease in the lower respiratory tract of adults...
2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28087317/acute-otitis-media-caused-by-streptococcus-pneumoniae-serotype-19a-st320-clone-epidemiological-and-clinical-characteristics
#16
Hsin Chi, Nan-Chang Chiu, Fu-Yuan Huang, Chyong-Hsin Hsu, Kuo-Sheng Lee, Li-Min Huang, Yu-Chia Hsieh
BACKGROUND: Streptococcus pneumoniae serotype 19A ST320, a highly multiresistant and virulent clone, has emerged as a common pathogen causing acute otitis media (AOM) in children. METHODS: Patients aged 0-18 years with AOM who presented at Mackay Memorial Hospital, Taipei, Taiwan were prospectively enrolled between December 1, 2009, and November 30, 2012. For each patient, a specimen of middle-ear fluid was obtained and cultured. S. pneumoniae isolates were tested by serotyping, antibiotic-resistance profiling, and multilocus sequence typing...
December 19, 2016: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28073387/recurrent-acute-otitis-media-detracts-from-health-related-quality-of-life
#17
T Kujala, O-P Alho, A Kristo, M Uhari, M Renko, T Pokka, P Koivunen
OBJECTIVE: Acute otitis media causes discomfort to children and inconvenience to their parents. This study evaluated the quality of life in children with recurrent acute otitis media aged less than 24 months. METHODS: Quality of life was evaluated in 149 children aged 10 to 24 months who were referred to the Oulu University Hospital on account of recurrent acute otitis media. The children were treated with or without surgery. Age-matched controls were selected randomly from the general child population...
February 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28056896/healthcare-seeking-behaviour-of-primary-caregivers-for-acute-otitis-media-in-children-aged-6%C3%A2-months-to-30%C3%A2-months-in-panama-results-of-a-cross-sectional-survey
#18
Iris Villarreal, Rosario Turner, Hyejin Jo, Julie Park, Eric Gemmen, Jean-Yves Pirçon, Maria M Castrejon, William P Hausdorff
BACKGROUND: Acute otitis media (AOM) is the most common bacterial childhood infection. However, caregivers with children having mild episodes often do not seek healthcare services, which may lead to an under-appreciation of the disease experienced by the community. The objectives of this survey were to estimate the proportion of primary caregivers who went to a healthcare facility when they suspected that their child aged 6 to <30 months was having an AOM episode during the past 6 months and to assess what factors influenced their decision...
January 5, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28031178/otitis-prone-children-produce-functional-antibodies-to-pneumolysin-and-pneumococcal-polysaccharides
#19
Lea-Ann S Kirkham, Selma P Wiertsema, Karli J Corscadden, Tulia Mateus, Gemma L Mullaney, Guicheng Zhang, Peter C Richmond, Ruth B Thornton
BACKGROUND: The pneumococcus is a major otitis media (OM) pathogen but data are conflicting on whether otitis-prone children have impaired humoral immunity to pneumococcal antigens. We and others have shown that otitis-prone and healthy children have similar antibody titres to pneumococcal proteins and polysaccharides (vaccine and non-vaccine type), however the quality of antibodies from otitis-prone children has not been investigated. Antibody function, rather than titre, is considered to better correlate with protection from pneumococcal disease...
December 28, 2016: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/28027286/the-relationship-of-the-middle-ear-effusion-microbiome-to-secretory-mucin-production-in-pediatric-patients-with-chronic-otitis-media
#20
Anna Krueger, Stéphanie Val, Marcos Pérez-Losada, Karuna Panchapakesan, Joe Devaney, Vanessa Duah, Christine DeMasson, Marian Poley, Mary Rose, Diego Preciado
BACKGROUND: Acute otitis media (AOM), an infection of the middle ear, can become chronic (COM) following multiple episodes. Microbial influence on COM remains unclear. It's been reported that mucin glycoproteins are required for middle ear immune defense against pathogens. We aim to characterize the middle ear effusion (MEE) microbiome using high-throughput sequencing and assess potential associations in microbiome diversity with the presence of the secretory mucins MUC5B and MUC5AC. We hypothesize that MEEs containing MUC5B will exhibit a microbiome largely devoid of typical AOM bacteria...
December 23, 2016: Pediatric Infectious Disease Journal
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