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María Julieta Russo, G Cohen, P Chrem Mendez, J Campos, M E Martín, M F Clarens, F Tapajoz, P Harris, G Sevlever, R F Allegri
INTRODUCTION: The performance of activities of daily living in elderly patients with memory disorders is directly related to living independently and to autonomy. Documenting and assessing functional capacity through detailed scales is important for both diagnostic and treatment recommendations. The Everyday Cognition (ECog) scale is a relatively new informant-rated measure of cognitive and functional abilities. In the present study, the discriminant validity of the ECog scale was evaluated in cognitively intact controls (CN) and in patients with mild cognitive impairment (MCI) and mild Alzheimer's disease (AD) from the Argentina-ADNI cohort to establish diagnostic accuracy...
January 29, 2018: Aging Clinical and Experimental Research
Bin Wang, Yan Niu, Liwen Miao, Rui Cao, Pengfei Yan, Hao Guo, Dandan Li, Yuxiang Guo, Tianyi Yan, Jinglong Wu, Jie Xiang, Hui Zhang
Alzheimer's disease (AD) is a frequently observed, irreversible brain function disorder among elderly individuals. Resting-state functional magnetic resonance imaging (rs-fMRI) has been introduced as an alternative approach to assessing brain functional abnormalities in AD patients. However, alterations in the brain rs-fMRI signal complexities in mild cognitive impairment (MCI) and AD patients remain unclear. Here, we described the novel application of permutation entropy (PE) to investigate the abnormal complexity of rs-fMRI signals in MCI and AD patients...
2017: Frontiers in Aging Neuroscience
Kelsey R Thomas, Emily C Edmonds, Lisa Delano-Wood, Mark W Bondi
OBJECTIVES: Within the Alzheimer's Disease Neuroimaging Initiative (ADNI)'s mild cognitive impairment (MCI) cohort, we previously identified MCI subtypes as well as participants initially diagnosed with MCI but found to have normal neuropsychological, biomarker, and neuroimaging profiles. We investigated the functional change over time in these empirically derived MCI subgroups. METHODS: ADNI MCI participants (n=654) were classified using cluster analysis as Amnestic MCI (single-domain memory impairment), Dysnomic MCI (memory+language impairments), Dysexecutive/Mixed MCI (memory+language+attention/executive impairments), or Cluster-Derived Normal (CDN)...
July 2017: Journal of the International Neuropsychological Society: JINS
Courtney Berezuk, Konstantine K Zakzanis, Joel Ramirez, Anthony C Ruocco, Jodi D Edwards, Brandy L Callahan, Sandra E Black
BACKGROUND: Gender differences in instrumental activities of daily living (IADLs) in mild cognitive impairment (MCI) and Alzheimer's disease may be explained by gender differences in IADL involvement. OBJECTIVE: We introduce a novel theoretical construct, termed functional reserve, and empirically examine gender differences in IADL experience as a proxy of this reserve. METHODS: We cross-sectionally examined men (n = 502) and women (n = 340) with MCI from the Alzheimer's Disease Neuroimaging Initiative (ADNI)...
2017: Journal of Alzheimer's Disease: JAD
Nare Torosyan, Kelsey Mason, Magnus Dahlbom, Daniel H S Silverman
PURPOSE: The aim of this study was to examine the value of fluorodeoxyglucose (FDG) positron emission tomography (PET) in predicting subsequent rates of functional and cognitive decline among subjects considered cognitively normal (CN) or clinically diagnosed with mild cognitive impairment (MCI). METHODS: Analyses of 276 subjects, 92 CN subjects and 184 with MCI, who were enrolled in the Alzheimer's Disease Neuroimaging Initiative, were conducted. Functional decline was assessed using scores on the Functional Activities Questionnaire (FAQ) obtained over a period of 36 months, while cognitive decline was determined using the Alzheimer's disease Assessment Scale-Cognitive subscale (ADAS-Cog) and Mini-Mental State Examination (MMSE) scores...
August 2017: European Journal of Nuclear Medicine and Molecular Imaging
Amy Lin, Jenny Brook, Joshua D Grill, Edmond Teng
OBJECTIVE: Clinical trials in incipient and clinical Alzheimer disease (AD) often include informant-reported outcomes. Whereas informant reports in AD dementia may be modulated by the nature of participant-informant relationships, whether informant type affects reporting at earlier disease stages is less certain. We sought to determine the effects of participant-informant relationships on informant assessments of quality of life (QOL), functional abilities, and behavioral symptoms in individuals with normal cognition (NC), mild cognitive impairment (MCI), and mild-to-moderate AD dementia...
March 2017: American Journal of Geriatric Psychiatry
Milap A Nowrangi, Paul B Rosenberg, Jeannie-Marie S Leoutsakos
BACKGROUND: There are relatively small but observable changes in functional ability in those without Mild cognitive impairment (MCI) or dementia. The present study seeks to understand whether these individuals go on to develop MCI or dementia by assessing the association between baseline Functional Activities Questionnaire (FAQ) and conversion independent and after adjustment for cognitive tests. METHODS: The NACC database was used to conduct the analysis of which 7,625 participants were initially identified as having more than one visit and who were cognitively normal at their first visit...
December 2016: International Psychogeriatrics
Navaldeep Kaur, Patricia Belchior, Isabelle Gelinas, Nathalie Bier
BACKGROUND: Mild deficits in instrumental activities of daily living (IADLs) have consistently been reported in the individuals with mild cognitive impairment (MCI). A variety of functional assessment tools, including self-and informant report questionnaires and performance-based measures, have been employed in MCI. Previously, a limited focus has been directed at appraising the quality of questionnaires. The goal of this study was to identify the questionnaires that have been validated in the MCI population...
September 2016: International Psychogeriatrics
Helen Hochstetler, Paula T Trzepacz, Shufang Wang, Peng Yu, Michael Case, David B Henley, Elisabeth Degenhardt, Jeannie-Marie Leoutsakos, Constantine G Lyketsos
BACKGROUND: Alzheimer's disease (AD) is associated with variable cognitive and functional decline, and it is difficult to predict who will develop the disease and how they will progress. OBJECTIVE: This exploratory study aimed to define latent classes from participants in the Alzheimer's Disease Neuroimaging Initiative (ADNI) database who had similar growth patterns of both cognitive and functional change using Growth Mixture Modeling (GMM), identify characteristics associated with those trajectories, and develop a decision tree using clinical predictors to determine which trajectory, as determined by GMM, individuals will most likely follow...
2016: Journal of Alzheimer's Disease: JAD
Juliana Francisco Cecato, José Eduardo Martinelli, Rafael Izbicki, Mônica Sanches Yassuda, Ivan Aprahamian
BACKGROUND: It is necessary to continue to explore the psychometric characteristics of key cognitive screening tests such as the Montreal Cognitive Assessment (MoCA) to diagnose cognitive decline as early as possible and to attend to the growing need of clinical trials involving mild cognitive impairment (MCI) participants. The main aim of this study was to assess which MoCA subtests could best discriminate between healthy controls (HC), participants with MCI, and Alzheimer's disease (AD)...
May 2016: International Psychogeriatrics
Paula T Trzepacz, Helen Hochstetler, Shufang Wang, Brett Walker, Andrew J Saykin
BACKGROUND: The Montreal Cognitive Assessment (MoCA) was developed to enable earlier detection of mild cognitive impairment (MCI) relative to familiar multi-domain tests like the Mini-Mental State Exam (MMSE). Clinicians need to better understand the relationship between MoCA and MMSE scores. METHODS: For this cross-sectional study, we analyzed 219 healthy control (HC), 299 MCI, and 100 Alzheimer's disease (AD) dementia cases from the Alzheimer's Disease Neuroimaging Initiative (ADNI)-GO/2 database to evaluate MMSE and MoCA score distributions and select MoCA values to capture early and late MCI cases...
September 7, 2015: BMC Geriatrics
Magdalena Hagovská, Peter Takáč, Oliver Dzvoník
BACKGROUND: An optimal frequency and duration of cognitive trainings and exercise has not yet been determined for improving balance and for positively influencing cognitive functions. AIM: To investigate whether the CogniPlus method with a dynamic balance training not only improves cognitive functions but also improves the postural control and functional status more than a balance training session alone in seniors with a mild cognitive deficit. DESIGN: Randomized, controlled trial...
February 2016: European Journal of Physical and Rehabilitation Medicine
M Berres, W A Kukull, A R Miserez, A U Monsch, S E Monsell, R Spiegel
INTRODUCTION: The PGSA (Placebo Group Simulation Approach) aims at avoiding problems of sample representativeness and ethical issues typical of placebo-controlled secondary prevention trials with MCI patients. The PGSA uses mathematical modeling to forecast the distribution of quantified outcomes of MCI patient groups based on their own baseline data established at the outset of clinical trials. These forecasted distributions are then compared with the distribution of actual outcomes observed on candidate treatments, thus substituting for a concomitant placebo group...
2014: Journal of Prevention of Alzheimer's Disease
Julia J Hsiao, Po H Lu, Joshua D Grill, Edmond Teng
BACKGROUND: Previous cross-sectional studies suggest that assessments of instrumental activities of daily living (IADLs) may be useful for operationalizing the differences in functional deficits seen in mild cognitive impairment (MCI) and dementia. However, their utility for longitudinal changes in IADLs in the transition between MCI and dementia remains unclear. METHODS: We analyzed longitudinal IADL data with the Functional Activities Questionnaire (FAQ) in stable (MCI-S; n = 1,318) or progressive (MCI-P; n = 1,108) MCI patients...
2015: Dementia and Geriatric Cognitive Disorders
Yifan Huang, Kaori Ito, Clare B Billing, Richard J Anziano
BACKGROUND: Although the Clinical Dementia Rating Scale-Sum of Boxes score (CDR-SB) is a widely accepted and commonly used global scale, validated clinical endpoints of cognitive changes are unavailable in the predementia stages of Alzheimer's disease (AD), and a new clinical assessment with reliability and sensitivity is needed in the mild cognitive impairment (MCI) population. METHODS: Using Alzheimer's Disease Neuroimaging Initiative (ADNI)-1/GO data, signal-to-noise ratios (SNRs) were calculated to quantify the sensitivity of a measure for detecting disease progression and hypothetical treatment effects...
April 2015: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
Angela Rizk-Jackson, Philip Insel, Ronald Petersen, Paul Aisen, Clifford Jack, Michael Weiner
This study aimed to identify baseline features of normal subjects that are associated with subsequent cognitive decline. Publicly available data from the Alzheimer's Disease Neuroimaging Initiative was used to find differences in baseline clinical assessments (ADAScog, AVLT, FAQ) between cognitively healthy individuals who will suffer cognitive decline within 48 months and those who will remain stable for that period. Linear regression models indicated an individual's conversion status was significantly associated with certain baseline neuroimaging measures, including posterior cingulate glucose metabolism...
2013: PloS One
Sepideh Shokouhi, Daniel Claassen, Hakmook Kang, Zhaohua Ding, Baxter Rogers, Arabinda Mishra, William R Riddle
UNLABELLED: Evaluating the symptomatic progression of mild cognitive impairment (MCI) caused by Alzheimer disease (AD) is practically accomplished by tracking performance on cognitive tasks, such as the Alzheimer Disease Assessment Scale's cognitive subscale (ADAS_cog), the Mini-Mental Status Examination (MMSE), and the Functional Activities Questionnaire (FAQ). The longitudinal relationships between cognitive decline and metabolic function as assessed using (18)F-FDG PET are needed to address both the cognitive and the biologic progression of disease state in individual subjects...
September 2013: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
R Scott Mackin, Philip Insel, Duygu Tosun, Susanne G Mueller, Norbert Schuff, Diana Truran-Sacrey, Sky T Raptentsetsang, Jun-Young Lee, Clifford R Jack, Paul S Aisen, Ronald C Petersen, Michael W Weiner
OBJECTIVE: To assess the effect of subsyndromal symptoms of depression (SSD) on ratings of disability for individuals with mild cognitive impairment (MCI). METHODS: Data from 405 MCI participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI) study were analyzed. Participants were evaluated at baseline and at 6-month intervals over 2 years. Severity of depressive symptoms was rated utilizing the Geriatric Depression Scale. Disability was assessed utilizing the Functional Assessment Questionnaire (FAQ)...
September 2013: American Journal of Geriatric Psychiatry
Thomas D Koepsell, Sarah E Monsell
OBJECTIVES: We sought to identify characteristics of individuals with mild cognitive impairment (MCI) that are associated with a relatively high probability of reverting back to normal cognition, and to estimate the risk of future cognitive decline among those who revert. METHODS: We first studied 3,020 individuals diagnosed with MCI on at least 1 visit to an Alzheimer's Disease Center in the United States. All underwent standardized Uniform Data Set evaluations at their first visit with an MCI diagnosis and on a subsequent visit, about 1 year later, at which cognitive status was reassessed...
October 9, 2012: Neurology
Edmond Teng, Kanida Tassniyom, Po H Lu
OBJECTIVES: To determine whether quality-of-life (QOL) ratings are reduced in mild cognitive impairment (MCI) and analyze correlations between QOL ratings and cognitive, neuropsychiatric, and functional indices in MCI. DESIGN: Cross-sectional. SETTING: The Easton Center for Alzheimer's Disease Research at the University of California, Los Angeles. PARTICIPANTS: A total of 205 individuals who met criteria for normal cognition (n = 97) or MCI (n = 108)...
December 2012: American Journal of Geriatric Psychiatry
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