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https://www.readbyqxmd.com/read/29325223/maternal-thyroid-hormone-insufficiency-during-pregnancy-and-risk-of-neurodevelopmental-disorders-in-offspring-a-systematic-review-and-meta-analysis
#1
William Thompson, Ginny Russell, Genevieve Baragwanath, Justin Matthews, Bijay Vaidya, Jo Thompson-Coon
BACKGROUND: In the last two decades, several studies have examined the association between maternal thyroid hormone insufficiency during pregnancy and neurodevelopmental disorders in children and shown conflicting results. AIM: This systematic review aimed to assess the evidence for an association between maternal thyroid hormone insufficiency during pregnancy and neurodevelopmental disorders in children. We also sought to assess whether levothyroxine treatment for maternal thyroid hormone insufficiency improves child neurodevelopment outcomes...
January 11, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29319359/secondary-and-tertiary-preventions-of-thyroid-disease
#2
Fereidoun Azizi, Ladan Mehran, Farhad Hosseinpanah, Hossein Delshad, Atieh Amouzegar
INTRODUCTION: Secondary and tertiary preventions are concerned with the recognition of the disease process in a very early stage and delay in progression to complete disease and minimization of complications and the impact of illness. METHODS: All articles related to secondary and tertiary prevention of thyroid diseases were reviewed. Using related key words, articles published between 2001 and 2015 were evaluated, categorized, and analyzed. RESULTS: In secondary prevention, congenital hypothyroidism and subclinical hypo and hyperthyroidism are equally important...
January 10, 2018: Endocrine Research
https://www.readbyqxmd.com/read/29317172/impact-of-positive-thyroid-autoimmunity-on-pregnant-women-with-subclinical-hypothyroidism
#3
Cristina López-Tinoco, Amparo Rodríguez-Mengual, Almudena Lara-Barea, Julia Barcala, Laura Larrán, Ana Saez-Benito, Manuel Aguilar-Diosdado
BACKGROUND: The impact of subclinical hypothyroidism (SH) and thyroid autoimmunity on obstetric and perinatal complications continues to be a matter of interest and highly controversial. AIM: To assess the impact of SH and autoimmunity in early pregnancy on the obstetric and perinatal complications in our population. MATERIAL AND METHOD: A retrospective cohort study in 435 women with SH (TSH ranging from 3.86 and 10 μIU/mL and normal FT4 values) in the first trimester of pregnancy...
January 6, 2018: Endocrinología, Diabetes y Nutrición
https://www.readbyqxmd.com/read/29285448/maternal-and-neonatal-outcome-in-mothers-with-gestational-diabetes-mellitus
#4
G Thiruvikrama Prakash, Ashok Kumar Das, Syed Habeebullah, Vishnu Bhat, Suryanarayana Bettadpura Shamanna
Introduction: Gestational diabetes mellitus (GDM) is common and is accompanied with other comorbidities. Challenges to treatment exist at our institute as it serves women with low income. This study assessed the burden of comorbidities and the outcome of GDM. Methods: This was a prospective, observational study of women with gestational diabetes attending the obstetrics department from September 2012 to April 2014. GDM was diagnosed based on the International Association of Diabetes and Pregnancy Study Groups criteria...
November 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29273014/-hypothyroidism-screening-during-first-trimester-of-pregnancy
#5
María Castillo Lara, Ángel Vilar Sánchez, Consuelo Cañavate Solano, Estefanía Soto Pazos, María Iglesias Álvarez, Carmen González Macías, Carmen Ayala Ortega, Luis Javier Moreno Corral, Juan Jesús Fernández Alba
BACKGROUND: Subclinical hypothyroidism is defined as an elevated thyroid-stimulating hormone level with a normal thyroxin level without signs or symptoms of hypothyroidism. Although it is well accepted that overt hypothyroidism has a deleterious impact on pregnancy, recent studies indicate that subclinical hypothyroidism may affect maternal and fetal health. Studies suggest an association between miscarriage and preterm delivery in euthyroid women positive for anti-peroxidase antibodies and/or anti-thyroglobulin antibodies...
December 22, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29246752/autoimmune-thyroid-disease-during-pregnancy
#6
REVIEW
Simone De Leo, Elizabeth N Pearce
Understanding of changes in thyroid function and the consequences of thyroid disease during pregnancy has rapidly grown in the past two decades, and revised American Thyroid Association guidelines on this topic were published in 2017. This Review explores the association between thyroid autoimmunity and complications during and after pregnancy. Thyroid autoimmunity refers to the presence of antibodies to thyroperoxidase or thyroglobulin, or thyroid-stimulating hormone receptor antibodies (TRAbs), or a combination of these, and is present in up to 18% of pregnant women...
December 12, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29244797/association-between-maternal-hypothyroidism-and-autism-spectrum-disorders-in-the-children
#7
Darios Getahun, Steven J Jacobsen, Michael J Fassett, Deborah A Wing, Anny H Xiang, Vicki Chiu, Morgan R Peltier
OBJECTIVE: To determine if hypothyroidism is associated with ASD and how this association is influenced by race-ethnicity, sex, and timing of exposure. METHODS: A retrospective cohort study was conducted using records from 397201 children who were delivered from 1991-2011 and remained health plan members from 1993-2014. RESULTS: Children of hypothyroid women had higher ASD rates than children of women without the diagnosis (2.14 vs. 1.62/1000 person-years; and adjusted hazard ratios [adj...
December 15, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29221723/effects-of-thyroxine-on-expression-of-proteins-related-to-thyroid-hormone-functions-tr-%C3%AE-tr-%C3%AE-rxr-and-erk1-2-in-uterus-during-peri-implantation-period
#8
Abu Sadat Md Sayem, Nelli Giribabu, Sekaran Muniandy, Naguib Salleh
INTRODUCTION: Thyroid hormone is known to play important role during embryo implantation, however mechanisms underlying its actions in uterus during peri-implantation period has not been fully identified. In this study, we hypothesized that thyroid hormone could affect expression of proteins related to its function, where these could explain mechanisms for its action in uterus during this period. METHODS: Female rats, once rendered hypothyroid via oral administration of methimazole (0...
December 5, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29220528/maternal-thyroid-function-in-early-pregnancy-and-neuropsychological-performance-of-the-child-at-5-years-of-age
#9
Stine Linding Andersen, Stig Andersen, Zeyan Liew, Peter Vestergaard, Jørn Olsen
Context: Abnormal maternal thyroid function in pregnancy may impair fetal brain development, but more evidence is needed to refine and corroborate the hypothesis. Objective: To estimate the association between maternal thyroid function in early pregnancy and neuropsychological performance of the child at 5 years of age. Design: Follow-up study. Participants: A cohort of 1,153 women and their children sampled from the Danish National Birth Cohort...
December 6, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29197845/neck-mass-an-obstructive-cause-of-respiratory-distress-with-medical-management
#10
Vijay Singh, Aakash Pandita, Girish Gupta, Amit Shukla
Congenital goitre is a known cause of hypothyroidism in newborn. Congenital goitre can be due to defective synthesis of thyroxine or administration of antithyroid drugs to the mother during pregnancy. In this case report, we report an instance of a preterm male infant with antenatally detected goitre presenting as a neck mass with congenital hypothyroidism. Hormonal replacement therapy was started immediately after birth which lead to resolution of the mass and normalisation of thyroid function.
December 2, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29175438/gestational-3-3-4-4-5-pentachlorobiphenyl-pcb-126-exposure-disrupts-fetoplacental-unit-fetal-thyroid-cytokines-dysfunction
#11
R G Ahmed
Exposure to polychlorinated biphenyls (PCBs) is related to several endocrine disorders. This study examined the effect of maternal exposure of 3,3',4,4',5-pentachlorobiphenyl (PCB 126) on the fetoplacental unit and fetal thyroid-cytokine axis during the pregnancy. Pregnant albino rats received PCB 126 (20 or 40μg/kgb.wt.) by oral gavage from gestation day (GD) 1 to 20. Potential effects of PCB 126 were evaluated by following the histopathological changes in the placenta by Haematoxylin and Eosin (H&E) stain and measuring the maternofetal thyroid axis (ELIZA), maternofetal body weight, and fetal growth markers (ELIZA), and cytokines (ELIZA) at embryonic day (ED) 20...
November 21, 2017: Life Sciences
https://www.readbyqxmd.com/read/29162475/-thyrotropin-reference-ranges-during-pregnancy-in-the-province-of-huelva-spain
#12
A Ortega Carpio, I Vázquez Rico, M A Castaño López, L Duarte González, M Montilla Álvaro, A Ruiz Reina
OBJECTIVE: The correct diagnosis of hypothyroidism during pregnancy requires knowledge of the local trimester-specific thyrotropin (TSH) reference ranges. When these are not available, the guidelines recommend upper limits of 2.5, 3.0, and 3.0μU/ml for the 1(st), 2(nd), and 3(rd) trimesters, respectively. The aim is to establish the reference range for our local population. MATERIAL AND METHODS: A population-based observational study was performed on healthy pregnant women from 11 healthcare centres in the province of Huelva...
November 18, 2017: Semergen
https://www.readbyqxmd.com/read/29159833/maternal-hypothyroidism-in-the-perinatal-period-and-childhood-asthma-in-the-offspring
#13
Xiaoqin Liu, Stine Linding Andersen, Jørn Olsen, Esben Agerbo, Vivi Schlünssen, Shyamali Chandrika Dharmage, Trine Munk-Olsen
BACKGROUND: There is increasing interest in the possible link between maternal hypothyroidism in the perinatal period and childhood asthma risk. We explored this in the present study while accounting for the timing of hypothyroidism diagnosis. Further, we evaluated whether the risk was moderated by thyroid hormone treatment during pregnancy. METHODS: We conducted a population-based cohort study using Danish national registers. All liveborn singletons in Denmark from 1998 to 2007 were identified...
November 21, 2017: Allergy
https://www.readbyqxmd.com/read/29158709/relationship-between-health-literacy-and-body-mass-index-among-arab-women-with-polycystic-ovary-syndrome
#14
Yazed Sulaiman Al-Ruthia, Bander Balkhi, Sultan AlGhadeer, Wael Mansy, Hisham AlSanawi, Reem AlGasem, Lama AlMutairi, Ibrahim Sales
Background: Polycystic ovary syndrome (PCOS) puts patients at higher risk for obesity and diabetes. Poor health literacy is also associated with these conditions. Notably, weight loss is associated with improved ovulation and pregnancy rates for women with PCOS. In this study the association between health literacy and body mass index (BMI) among women with PCOS was examined. Methods: The health literacy of women with PCOS was measured using the Arabic version of the single item literacy screener (SILS) at a university medical center...
November 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29142304/maternal-exposure-to-iodine-excess-throughout-pregnancy-and-lactation-induces-hypothyroidism-in-adult-male-rat-offspring
#15
Caroline Serrano-Nascimento, Rafael Barrera Salgueiro, Thiago Pantaleão, Vânia Maria Corrêa da Costa, Maria Tereza Nunes
This study aimed to investigate the consequences of maternal exposure to iodine excess (IE; 0.6 mg NaI/L) throughout pregnancy and lactation on the hypothalamus-pituitary-thyroid axis of the male offspring in adulthood. Maternal IE exposure increased hypothalamic Trh mRNA expression and pituitary Tsh expression and secretion in the adult male offspring. Moreover, the IE-exposed offspring rats presented reduced thyroid hormones levels, morphological alterations in the thyroid follicles, increased thyroid oxidative stress and decreased expression of thyroid differentiation markers (Tshr, Nis, Tg, Tpo, Mct8) and thyroid transcription factors (Nkx2...
November 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29141467/oxidative-stress-biomarkers-in-amniotic-fluid-of-pregnant-women-with-hypothyroidism
#16
Tanja R Novakovic, Zana C Dolicanin, Natasa Z Djordjevic
PURPOSE: Hypothyroidism in pregnancy is the serious state that may lead to fetal morbidity and mortality. Oxidative stress biomarkers in the amniotic fluid can provide important information on the health, development and maturation of the fetus during pregnancy. In this study, we examined whether maternal hypothyroidism contributes to increased oxidative stress biomarkers in the amniotic fluid during the first trimester of pregnancy. MATERIALS AND METHODS: The study was conducted on healthy pregnant women and pregnant women with hypothyroidism (gestational age: 16-18 weeks)...
November 15, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29126290/effects-of-levothyroxine-on-pregnant-women-with-subclinical-hypothyroidism-negative-for-thyroid-peroxidase-antibodies
#17
Sima Nazarpour, Fahimeh Ramezani Tehrani, Masoumeh Simbar, Maryam Tohidi, Sonia Minooee, Maryam Rahmati, Fereidoun Azizi
Context: Currently, there is no consensus on universal thyroid screening and Levothyroxine (LT4) treatment of subclinical hypothyroid pregnant women who are negative for thyroid peroxidase antibody (SCH-TPOAb-). Objective: We aimed to evaluate the benefits of LT4 treatment on pregnancy outcomes in SCH-TPOAb- women. Design: This study was conducted within the framework of the Tehran Thyroid and pregnancy study. A single-blind randomized clinical trial was undertaken on SCH-TPOAb- pregnant women...
November 6, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29120650/-thyroid-screening-in-pregnancy-guideline-in-practice
#18
Patrícia Páleníková, Iveta Kalafutová, Zdenka Horníková, Juraj Payer
Thyroid diseases may adversely affect the conception, maintain pregnancy. They increase the risk of complications in pregnancy and may have a negative effect on the fetus. Therefore it is necessary to capture thyroid diseases in the population of pregnant women, in the early stage of pregnancy. In Slovakia, since 2009, the Expert Guideline of the Ministry of Health of the Slovak Republic for the diagnosis and treatment of autoimmune thyroid diseases in women during pregnancy has been in force. In our patient cohort, we monitored 666 pregnant patients, the timeliness of screening, thyroid parameters, the number of pregnancies and their complications, the need for levothyroxine treatment...
2017: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29111858/women-s-health-endocrine-update
#19
Ekta Kapoor, Stephanie Faubion, Stephanie Hines, Cynthia A Stuenkel
The clinical update serves as a brief review of recently published, high-impact, and potentially practice changing journal articles summarized for our readers. Topics include menopause, sexual dysfunction, breast health, contraception, osteoporosis, and cardiovascular disease. In this clinical update, we selected four recent high-impact publications related to endocrine issues in women. We have chosen to highlight research on subclinical hypothyroidism during pregnancy and adverse pregnancy outcomes, including cognitive outcomes in offspring; the progression of metabolic syndrome severity during the menopausal transition; and the association of diabetes and metformin use with cancer risk and mortality...
November 7, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/29084139/the-impact-of-iodine-status-on-the-recall-rate-of-the-screening-program-for-congenital-hypothyroidism-findings-from-two-national-studies-in-iran
#20
Ladan Mehran, Shahin Yarahmadi, Davood Khalili, Pantea Nazeri, Hossein Delshad, Zahra Abdollahi, Nasrin Azhang, Fereidoun Azizi
Back ground: Iodine deficiency is one of the important factors in increasing the recall rate in congenital hypothyroidism (CH) screening programs. The present study assessed whether the iodine status of the general population may predict the recall rate or vice versa. METHODS: In the current national study, among 1,382,229 live births delivered between March 2010 and March 2011, 1,288,237 neonates were screened for detecting CH by TSH (thyroid stimulating hormone) measurement via heel prick sampling...
October 30, 2017: Nutrients
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