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Post op nausea and vomiting

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https://www.readbyqxmd.com/read/26011551/association-between-gastrointestinal-events-and-persistence-with-osteoporosis-therapy-analysis-of-administrative-claims-of-a-u-s-managed-care-population
#1
Ankita Modi, S Siris, Xiaoqin Yang, Chun-Po Steve Fan, Shiva Sajjan
BACKGROUND: A large proportion of patients do not persist with osteoporosis (OP) therapy. Gastrointestinal (GI) events (e.g., gastroesophageal reflux disease and nausea/vomiting) are common among OP patients receiving OP therapy and may impact persistence with treatment. OBJECTIVE: To examine the association of GI events and persistence with OP therapy. METHODS: Using a large U.S. administrative claims database, we studied women aged ≥ 55 years who received oral bisphosphonate (BIS) as their first OP therapy from 2002-2009...
June 2015: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/25866298/gastrointestinal-events-among-patients-initiating-osteoporosis-therapy-a-retrospective-administrative-claims-database-analysis
#2
Ankita Modi, Ethel S Siris, Chun-Po Steve Fan, Shiva Sajjan
PURPOSE: Our purpose was to characterize the occurrence of gastrointestinal (GI) events among women on oral bisphosphonate therapy. METHODS: This was a retrospective cohort study that used a United States (US) claims database. The study period was from January 1, 2000, to December 31, 2011. The index date was the date of the first oral bisphosphonate (alendronate, ibandronate, or risedronate) prescription and occurred between January 1, 2001, and December 31, 2010...
June 1, 2015: Clinical Therapeutics
https://www.readbyqxmd.com/read/25433175/comparison-of-bariatric-restrictive-operations-laparoscopic-sleeve-gastrectomy-and-laparoscopic-gastric-greater-curvature-plication
#3
Ryan C Broderick, Hans F Fuchs, Cristina R Harnsberger, Bryan J Sandler, Garth R Jacobsen
Morbid obesity continues to increase in prevalence, becoming a major socioeconomic and medical problem. The success in treating morbid obesity with surgery has been well documented. The categories of surgical treatment include restrictive, malabsorptive, and combination operations. Two of the restrictive operations at the forefront of today's treatments are laparoscopic sleeve gastrectomy (LSG) and laparoscopic gastric greater curvature plication (LGCP). A literature review has been completed to compare the current technique and results for LSG and LGCP...
November 2014: Surgical Technology International
https://www.readbyqxmd.com/read/22345953/reduction-in-the-incidence-of-shivering-with-perioperative-dexmedetomidine-a-randomized-prospective-study
#4
Sukhminder Jit Singh Bajwa, Sachin Gupta, Jasbir Kaur, Amarjit Singh, Ss Parmar
BACKGROUND AND AIMS: Shivering is distressing to the patient and discomforting to the attending anesthesiologist, with a varying degree of success. Various drugs and regimens have been employed to abolish the occurrence of shivering. The present study aims to explore the effectiveness of dexmedetomidine in suppressing the postanesthetic shivering in patients undergoing general anesthesia. MATERIALS AND METHODS: The present study was carried out on 80 patients, in American Society of Anesthesiologists I and II, aged 22-59 years, who underwent general anesthesia for laparoscopic surgical procedures...
January 2012: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/22144922/comparative-evaluation-of-dexmedetomidine-and-fentanyl-for-epidural-analgesia-in-lower-limb-orthopedic-surgeries
#5
Sukhminder Jit Singh Bajwa, Vikramjit Arora, Jasbir Kaur, Amarjit Singh, S S Parmar
BACKGROUND AND AIMS: Opioids as epidural adjunct to local anesthetics (LA) have been in use since long and α-2 agonists are being increasingly used for similar purpose. The present study aims at comparing the hemodynamic, sedative, and analgesia potentiating effects of epidurally administered fentanyl and dexmedetomidine when combined with ropivacaine. METHODS: A total of one hundred patients of both gender aged 21-56 years, American Society of Anaesthesiologist (ASA) physical status I and II who underwent lower limb orthopedic surgery were enrolled into the present study...
October 2011: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/22045112/use-of-oros%C3%A2-hydromorphone-in-the-treatment-of-osteoarthritis-and-osteoporosis-a-pooled-analysis-of-three-non-interventional-studies-focusing-on-different-starting-doses
#6
MULTICENTER STUDY
Johann D Ringe, Susanne Schäfer, Antonie M Wimmer, Thorsten Giesecke
OBJECTIVE: To determine the effect of a lower starting dose of OROS® hydromorphone compared with a higher starting dose. DESIGN: Data from the first 15 days of treatment were compared in a combined analysis of three prospective, non-interventional studies. SETTING: Non-interventional, carried out in daily routine settings. PATIENTS: Patients had chronic severe pain due to osteoarthritis or from fragility fractures related to osteoporosis...
January 2012: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/21655011/palonosetron-a-novel-approach-to-control-postoperative-nausea-and-vomiting-in-day-care-surgery
#7
Sukhminderjit Singh Bajwa, Sukhwinder Kaur Bajwa, Jasbir Kaur, Veenita Sharma, Amarjit Singh, Anita Singh, Sps Goraya, Ss Parmar, Kamaljit Singh
BACKGROUND: Postoperative nausea and vomiting (PONV) is one of the complications which hamper the successful implementation of day care surgical procedure in spite of the availability of so many antiemetic drugs and regimens for its prevention. The aim was to compare the prophylactic effects of intravenously (IV) administered ondansetron and palonosetron on PONV prevention in patients undergoing laparoscopic gynecological surgery under general anesthesia. METHODS: A prospective double-blind study comprised of 60 ASAI/II female patients between the age group of 25 and 40 years was carried out in the Departments of Anesthesiology and Obstetrics and Gynecology of our institute...
January 2011: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/20214694/randomized-cross-over-trial-comparing-inpatient-and-outpatient-administration-of-high-dose-cisplatin
#8
RANDOMIZED CONTROLLED TRIAL
K M Cox, S Goel, R L O'Connell, M Boyer, P J Beale, R J Simes, M R Stockler
BACKGROUND/AIMS: Treatment with high-dose cisplatin (HDC) previously required inpatient (IP) admission with overnight hospitalization, but recently practice has shifted to outpatient (OP) therapy. We aimed to determine whether it is preferable to give HDC as an IP or OP using a two-period cross-over trial. METHODS: Eligible patients were starting chemotherapy with ≥2 cycles of HDC (≥100 mg/dose) and were suitable for OP treatment. All patients received an IP cycle and OP cycle: the order was randomly allocated...
February 2011: Internal Medicine Journal
https://www.readbyqxmd.com/read/20146087/a-prospective-evaluation-and-literature-review-of-levetiracetam-use-in-patients-with-brain-tumors-and-seizures
#9
REVIEW
Justin B Usery, L Madison Michael, Allen K Sills, Christopher K Finch
To determine the safety and tolerability of IV and oral levetiracetam monotherapy for seizures in brain tumor patients following resection. Brain tumor patients undergoing neurosurgery with >or=1 seizure within the preceding month prior to surgery were enrolled to receive intravenous levetiracetam for a minimum of 48 h, transitioned to oral levetiracetam at the same dose, and followed for 1-month after discharge. Patients were assessed daily in the hospital, provided with a seizure diary, and supplied with 30 days of levetiracetam upon discharge...
September 2010: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/19817719/the-potential-for-mu-opioid-receptor-agonists-to-be-anti-emetic-in-humans-a-review-of-clinical-data
#10
REVIEW
Kevin D Johnston
In animal models of vomiting, mu-opioid (MOP, OP(3)) receptors mediate both emesis and anti-emesis. mu-receptors within the blood-brain barrier, mediating anti-emesis, are more rapidly accessible to lipid-soluble mu-opioid receptor agonists such as fentanyl than to morphine, and fentanyl has broad-spectrum anti-emetic effects in a number of species. Whether a similar situation exists in humans is not known. A search was performed for clinical studies comparing the emetic side effects of opioids administered peri-operatively in an attempt to identify differences between morphine and more lipid-soluble mu-receptor-selective agonists such as fentanyl...
February 2010: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/18633023/the-impact-of-current-antiemetic-practices-on-patient-outcomes-a-prospective-study-on-high-risk-patients
#11
MULTICENTER STUDY
Paul F White, Jerome F O'Hara, Charles R Roberson, Ronald H Wender, Keith A Candiotti
BACKGROUND: In this prospective, multicenter, observational study, we evaluated the incidence and time course of postoperative nausea and vomiting (PONV), assessed prophylactic and rescue antiemetic use in high-risk patients, and determined population-based effectiveness of antiemetics, including the impact of American Society of Anesthesiologists (ASA) and American Society of Perianesthesia Nurses (ASPAN) guideline compliance. METHODS: Eligible patients undergoing elective laparoscopic or major plastic surgery possessed two or more of the following Apfel PONV risk factors: female gender, history of PONV or motion sickness, and nonsmoking status...
August 2008: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/15830768/post-operative-analgesia-with-intrathecal-morphine
#12
Samia Sfeir, Nabil Mansour
INTRODUCTION: Sixty eight ASA I and II patients between 18 and 84 years who underwent minor to medium surgery were studied retrospectively. They were divided into 2 groups, on basis on intrathecal morphine administration. MATERIALS AND METHODS: Group I received spinal anesthesia with bupivacaine 12.5-15 mg. Group II received in addition 0.1 mg morphine (preservative free) [MO PF]. Pain assessment, up to 24 hours, was evaluated by the need of salvage medication namely pethidine i...
February 2005: Middle East Journal of Anesthesiology
https://www.readbyqxmd.com/read/15309382/safety-profile-of-raloxifene-as-used-in-general-practice-in-england-results-of-a-prescription-event-monitoring-study
#13
MULTICENTER STUDY
Deborah Layton, Andrea Clarke, Lynda V Wilton, Saad A W Shakir
Raloxifene, a selective estrogen receptor modulator (SERM) licensed for the prevention of non-traumatic vertebral fractures in postmenopausal women at increased risk of osteoporosis, was launched in the UK in August 1998. The aim of the study was to monitor the safety of raloxifene prescribed in the primary care setting in England using prescription-event monitoring (PEM). Patients were identified by means of prescription data supplied by the Prescription Pricing Authority between September 1998 and November 2000...
May 2005: Osteoporosis International
https://www.readbyqxmd.com/read/12730757/pharmacovigilance-study-of-alendronate-in-england
#14
Pipasha N Biswas, Lynda V Wilton, Saad A W Shakir
Alendronate sodium is an aminobiphosphonate, an analog of inorganic pyrophosphate, indicated for the treatment of osteoporosis in post-menopausal women. We analyzed events reported in patients prescribed alendronate by general practitioners (GPs) in England. A non-interventional observational cohort study was conducted using the technique of prescription event monitoring (PEM). Exposure data were obtained from dispensed prescriptions issued between October 1995 and January 1997. Outcome data were obtained by sending questionnaires to prescribing GPs...
July 2003: Osteoporosis International
https://www.readbyqxmd.com/read/11928027/laparoscopic-cholecystectomy
#15
RANDOMIZED CONTROLLED TRIAL
M J Curet, M Contreras, D M Weber, R Albrecht
BACKGROUND: This study was undertaken to determine if patients undergoing laparoscopic cholecystectomy may be discharged home 4 h postoperatively with similar outcomes as patients admitted overnight. METHODS: Patients were randomized to an outpatient group (OP), consisting of patients who were discharged after a 4-h stay in the Post Anesthesia Care Unit (PACU), or to an inpatient group. Variables compared between the two groups included patient demographics; degree of postoperative pain, nausea, vomiting, and patient satisfaction; amount of pain and nausea medication taken; and number of phone calls, readmissions, or complications...
March 2002: Surgical Endoscopy
https://www.readbyqxmd.com/read/11793943/-esophagus-enteric-anastomosis-ulceration-caused-by-alendronate
#16
P Duques, R S Araújo, W P de Amorim
BACKGROUND: Alendronate sodium is an aminobisphosphonate indicated for the treatment of osteoporosis in post-menopausal women and has been associated with esophagitis in many reports. Esophageal stenosis, gastrointestinal symptoms as dyspepsia, nausea, vomiting and abdominal pain could be present. OBJECTIVE: Report a case of a patient who underwent total gastrectomy with Y-en-Roux anastomosis for a gastric carcinoid tumor and developed an esophagus-enteric anastomosis ulceration after the use of alendronate...
April 2001: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/9667093/united-kingdom-experience-with-alendronate-and-oesophageal-reactions
#17
F J Mackay, L V Wilton, G L Pearce, S N Freemantle, R D Mann
Alendronate is indicated for the treatment of osteoporosis in post-menopausal women. Although the drug has been associated with reports of severe oesophagitis, there have been no studies establishing the incidence of such reactions. Information was collected on 1523 patients included in a study conducted by means of prescription-event monitoring. Dyspepsia, nausea/vomiting, and abdominal pain were the most frequently reported events in the first month of treatment. After follow-up, 20 patients (1.3%) experienced oesophageal events that were considered to be possibly related to alendronate...
April 1998: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/616977/-treatment-of-extreme-obesity
#18
C de la Rosa, J González Barranco, A Miranda, E López Amor
23 patients whose weight varied from ninety-eight to 220 kilos were subjected to four different types of jejuno-ileal by pass operations: terminal-lateral (14 X 4) in three, terminal-terminal (14 X 4) in fifteen, (12 X 8) in two, and (10 X 8) in three. The defunctionalized intestine was anastomized to the transverse colon. Liver, jejenum and ileal biopsies as well as profilactic apendectomy were performed in all the cases along with colecistectomy when possible. All our patients were carefully studied in the pre and postoperative periods...
September 1977: Revista de Gastroenterología de México
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