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https://www.readbyqxmd.com/read/29790790/the-effects-of-amantadine-on-traumatic-brain-injury-outcome-a-double-blind-randomized-controlled-clinical-trial
#1
Hossein Ghalaenovi, Arash Fattahi, Jalil Koohpayehzadeh, Mahmoud Khodadost, Neda Fatahi, Morteza Taheri, Alireza Azimi, Sadra Rohani, Hessam Rahatlou
INTRODUCTION: Amantadine, as a dopamine receptor agonist, may stimulate and help the recovery of the nervous system after traumatic brain injury (TBI). METHODS: We performed this study as a double-blind, randomized, controlled clinical trial with target population including all patients with TBI who scored nine or lower on the Glasgow Coma Scale (GCS), admitted to our hospital between January 2013 and April 2014. The protocol included administration of the drug (placebo or amantadine) for 6 weeks and patient evaluation using the GCS and FOUR score on the first, third and seventh days after the drug was started...
May 23, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29790476/-erratum-to-translation-and-validation-of-the-four-scale-for-children-and-its-use-as-outcome-predictor-a-pilot-study
#2
Sofia Simões Ferreira, Daniel Meireles, Alexandra Pinto, Francisco Abecasis
The article "Translation and Validation of the FOUR Scale for Children and its Use as Outcome Predictor: A Pilot Study", published by Acta Médica Portuguesa on September 2017 [Acta Med Port 2017 Sep;30(9):599-607] exhibited the mistake detailed here below: On page 600, paragrapah 4, where it reads: "(...) only the last two are assessed by the GCS and depth of coma may not be accurately detected.4" It should read: "(…) GCS does not include important indicators for an adequate evaluation of coma severity, that is, it only evaluates the cortical function, not including brainstem function evaluation parameters such as respiratory pattern, pupil size and reflexes, nor eye movements; as such it may not detect the coma depth properly...
March 29, 2018: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/29770221/risperidone-induced-type-2-diabetes-presenting-with-diabetic-ketoacidosis
#3
Clarissa Ern Hui Fang, Mohammed Faraz Rafey, Aine Cunningham, Sean F Dinneen, Francis M Finucane
A 28-year-old male presented with 2 days of vomiting and abdominal pain, preceded by 2 weeks of thirst, polyuria and polydipsia. He had recently started risperidone for obsessive-compulsive disorder. He reported a high dietary sugar intake and had a strong family history of type 2 diabetes mellitus (T2DM). On admission, he was tachycardic, tachypnoeic and drowsy with a Glasgow Coma Scale (GCS) of 10/15. We noted axillary acanthosis nigricans and obesity (BMI 33.2 kg/m2 ). Dipstick urinalysis showed ketonuria and glycosuria...
2018: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29766124/routine-repeat-head-ct-may-not-be-necessary-for-patients-with-mild-tbi
#4
Claire B Rosen, Diego D Luy, Molly R Deane, Thomas M Scalea, Deborah M Stein
Background: Routine repeat cranial CT (RHCT) is standard of care for CT-verified traumatic brain injury (TBI). Despite mixed evidence, those with mild TBI are subject to radiation and expense from serial CT scans. Thus, we investigated the necessity and utility of RHCT for patients with mild TBI. We hypothesized that repeat head CT in these patients would not alter patient care or outcomes. Methods: We retrospectively studied patients suffering from mild TBI (Glasgow Coma Scale (GCS) score 13-15) and treated at the R Adams Cowley Shock Trauma Center from November 2014 through January 2015...
2018: Trauma surgery & acute care open
https://www.readbyqxmd.com/read/29715656/advanced-biological-activated-carbon-filter-for-removing-pharmaceutically-active-compounds-from-treated-wastewater
#5
Luca Sbardella, Joaquim Comas, Alessio Fenu, Ignasi Rodriguez-Roda, Marjoleine Weemaes
Through their release of effluents, conventional wastewater treatment plants (WWTPs) represent a major pollution point sources for pharmaceutically active compounds (PhACs) in water bodies. The combination of a biological activated carbon (BAC) filter coupled with an ultrafiltration (UF) unit was evaluated as an advanced treatment for PhACs removal at pilot scale. The BAC-UF pilot plant was monitored for one year. The biological activity of the biofilm that developed on the granular activated carbon (GAC) particles and the contribution of this biofilm to the overall removal of PhACs were evaluated...
April 28, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29696116/comparison-of-glasgow-coma-scale-full-outline-of-unresponsiveness-and-acute-physiology-and-chronic-health-evaluation-in-prediction-of-mortality-rate-among-patients-with-traumatic-brain-injury-admitted-to-intensive-care-unit
#6
Seyed Hossein Hosseini, Mitra Ayyasi, Hooshang Akbari, Mohammad Ali Heidari Gorji
Background: Traumatic brain injury (TBI) is a common cause of mortality and disability worldwide. Choosing an appropriate diagnostic tool is critical in early stage for appropriate decision about primary diagnosis, medical care and prognosis. Objectives: This study aimed to compare the Glasgow coma scale (GCS), full outline of unresponsiveness (FOUR) and acute physiology and chronic health evaluation (APACHE II) with respect to prediction of the mortality rate of patients with TBI admitted to intensive care unit...
October 2017: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/29667477/return-to-work-after-severe-traumatic-brain-injury-a-national-study-with-a-one-year-follow-up-of-neurocognitive-and-behavioural-outcomes
#7
Solrun Sigurdardottir, Nada Andelic, Eike Wehling, Audny Anke, Toril Skandsen, Oyvor Oistensen Holthe, Unn Sollid Manskow, Cecilie Roe
The objectives were to investigate the frequency of return-to-work (RTW) one year after severe traumatic brain injury (sTBI: Glasgow Coma Scale, GCS 3-8) and to identify which demographic and injury-related characteristics and neurocognitive factors are associated with RTW. This study is part of a prospective national study on sTBI conducted in all four Norwegian Trauma Referral Centres, including patients aged >15 years over a period of three years (n = 378). For the purpose of this study, only pre-employed individuals of working age (16 to 67 years) were investigated for RTW (n = 143), and of these, 104 participants underwent neuropsychological testing...
April 18, 2018: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/29657729/risk-factors-for-prolonged-mechanical-ventilation-in-patients-with-severe-multiple-injuries-and-blunt-chest-trauma-a-single-center-retrospective-case-control-study
#8
Yasuyuki Okabe
Aim: Blunt chest trauma is common and is associated with morbidity and mortality in patients with multiple injuries, frequently requiring invasive mechanical ventilation. The aim of this study was to elucidate risk factors for prolonged mechanical ventilation (PMV). Methods: Consecutive adult patients with multiple severe injuries and blunt chest trauma who treated in Chiba Emergency Medical Center (Chiba, Japan) between January 2008 and December 2015 were enrolled in this retrospective chart-review study...
April 2018: Acute Medicine & Surgery
https://www.readbyqxmd.com/read/29599633/the-factors-associated-with-outcomes-in-surgically-managed-ruptured-cerebral-aneurysm
#9
Lai Chuang Chee, Johari Adnan Siregar, Abdul Rahman Izani Ghani, Zamzuri Idris, Noor Azman A Rahman Mohd
Background: Ruptured cerebral aneurysm is a life-threatening condition that requires urgent medical attention. In Malaysia, a prospective study by the Umum Sarawak Hospital, Neurosurgical Center, in the year 2000-2002 revealed an average of two cases of intracranial aneurysms per month with an operative mortality of 20% and management mortality of 25%. Failure to diagnose, delay in admission to a neurosurgical centre, and lack of facilities could have led to the poor surgical outcome in these patients...
February 2018: Malaysian Journal of Medical Sciences: MJMS
https://www.readbyqxmd.com/read/29579354/penetrating-head-injuries-in-children-presenting-to-the-emergency-department-in-australia-and-new-zealand-a-predict-prospective-study
#10
Franz E Babl, Mark D Lyttle, Silvia Bressan, Meredith L Borland, Natalie Phillips, Amit Kochar, Sarah Dalton, John A Cheek, Yuri Gilhotra, Jeremy Furyk, Jocelyn Neutze, Susan Donath, Stephen Hearps, Marta Arpone, Louise Crowe, Stuart R Dalziel, Ruth Barker, Ed Oakley
AIM: Penetrating head injuries (pHIs) are associated with high morbidity and mortality. Data on pHIs in children outside North America are limited. We describe the mechanism of injuries, neuroimaging findings, neurosurgery and mortality for pHIs in Australia and New Zealand. METHODS: This was a planned secondary analysis of a prospective observational study of children <18 years who presented with a head injury of any severity at any of 10 predominantly paediatric Australian/New Zealand emergency departments (EDs) between 2011 and 2014...
March 26, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29577222/-establishment-of-comprehensive-prediction-model-of-acute-gastrointestinal-injury-classification-of-critically-ill-patients
#11
Yan Wang, Jianrong Wang, Weiwei Liu, Guangliang Zhang
OBJECTIVE: To develop the comprehensive prediction model of acute gastrointestinal injury (AGI) grades of critically ill patients. METHODS: From April 2015 to November 2015, the binary channel gastrointestinal sounds (GIS) monitor system which has been developed and verified by the research group was used to gather and analyze the GIS of 60 consecutive critically ill patients who were admitted in Critical Care Medicine of Chinese PLA General Hospital. Also, the AGI grades (Grande I(-IIII(, the higher the level, the heavier the gastrointestinal dysfunction) were evaluated...
March 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29428346/improvement-on-the-coma-recovery-scale-revised-during-the-first-four-weeks-of-hospital-stay-predicts-outcome-at-discharge-in-intensive-rehabilitation-after-severe-brain-injury
#12
Emilio Portaccio, Azzurra Morrocchesi, Anna Maria Romoli, Bahia Hakiki, Maria Pia Taglioli, Elena Lippi, Martina Di Renzone, Antonello Grippo, Claudio Macchi
OBJECTIVES: To evaluate the prognostic utility of serial assessment on the Coma Recovery Scale-Revised (CRS-R) during the first 4 weeks of intensive rehabilitation in patients surviving a severe brain injury. DESIGN: Prospective cohort study. SETTING: An intensive rehabilitation unit. PARTICIPANTS: Patients (N=110) consecutively admitted to the intensive rehabilitation unit. Inclusion criteria were (1) a diagnosis of unresponsive wakefulness syndrome (UWS) or minimally conscious state (MCS) caused by an acquired brain injury, and (2) aged >18 years...
May 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29415814/application-of-the-four-score-in-intracerebral-hemorrhage-risk-analysis
#13
Sherri A Braksick, J Claude Hemphill, Jay Mandrekar, Eelco F M Wijdicks, Jennifer E Fugate
BACKGROUND: The Full Outline of Unresponsiveness (FOUR) Score is a validated scale describing the essentials of a coma examination, including motor response, eye opening and eye movements, brainstem reflexes, and respiratory pattern. We incorporated the FOUR Score into the existing ICH Score and evaluated its accuracy of risk assessment in spontaneous intracerebral hemorrhage (ICH). MATERIALS AND METHODS: Consecutive patients admitted to our institution from 2009 to 2012 with spontaneous ICH were reviewed...
June 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29389807/a-multidisciplinary-program-reduces-over-24-hours-of-physical-restraint-in-neurological-intensive-care-unit
#14
Yu-Li Lin, Cheng-Chih Liao, Wen-Pin Yu, Tsung-Lan Chu, Lun-Hui Ho
BACKGROUND: Physical restraint (PR) has to be performed in a well-organized, structured, and careful manner. The safety and effectiveness of the PR procedure in clinical practice are crucial to patient care. PURPOSES: The aim of this study was to examine the effect in neurological intensive care units of a multidisciplinary PR reduction program on the overall incidence rate of PR, the monthly rate of PR, and the monthly rate of PR of more than and less than 24 hours, respectively, after controlling for associated factors...
January 31, 2018: Journal of Nursing Research: JNR
https://www.readbyqxmd.com/read/29370050/impact-of-venorrhaphy-and-vein-ligation-in-isolated-lower-extremity-venous-injuries-on-venous-thromboembolism-and-edema
#15
Nathan R Manley, Louis J Magnotti, Timothy C Fabian, Martin A Croce, John P Sharpe
BACKGROUND: Following venous injury, venorrhaphy can restore outflow, although it risks thrombosis and venous thromboembolism (VTE). Vein ligation is a faster option, although it potentially risks extremity edema. The purpose of this study was to evaluate the management of venous injury on VTE and extremity edema in patients with isolated lower-extremity venous injuries. METHODS: Patients with common iliac, external iliac, and femoral venous injuries over a 10-year period were stratified by age, shock, management of venous injury, injury severity, and timing and type of anticoagulation...
February 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29370008/initiating-nutritional-support-before-72-hours-is-associated-with-favorable-outcome-after-severe-traumatic-brain-injury-in-children-a-secondary-analysis-of-a-randomized-controlled-trial-of-therapeutic-hypothermia
#16
Elizabeth Meinert, Michael J Bell, Sandra Buttram, Patrick M Kochanek, Goundappa K Balasubramani, Stephen R Wisniewski, P David Adelson
OBJECTIVES: To understand the relationship between the timing of initiation of nutritional support in children with severe traumatic brain injury and outcomes. DESIGN: Secondary analysis of a randomized, controlled trial of therapeutic hypothermia (Pediatric Traumatic Brain Injury Consortium: Hypothermia, also known as "the Cool Kids Trial" (NCT 00222742). SETTINGS: Fifteen clinical sites in the United States, Australia, and New Zealand...
April 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29360717/noncompliance-with-american-college-of-surgeons-committee-on-trauma-recommended-criteria-for-full-trauma-team-activation-is-associated-with-undertriage-deaths
#17
Christopher J Tignanelli, Wayne E Vander Kolk, Judy N Mikhail, Matthew J Delano, Mark R Hemmila
BACKGROUND: The appropriate triage of acutely injured patients within a trauma system is associated with improved rates of mortality and optimal resource utilization. The American College of Surgeons Committee on Trauma (ACS-COT) put forward six minimum criteria (ACS-6) for full trauma team activation (TTA). We hypothesized that ACS-COT-verified trauma center compliance with these criteria is associated with low undertriage rates and improved overall mortality. METHODS: Data from a state-wide collaborative quality initiative was used...
February 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29246600/prediction-of-conscious-awareness-recovery-after-severe-acute-ischemic-stroke
#18
Yajuan Hu, Changqing Wang, Xiaoxiang Yan, Hong Fu, Kai Wang
BACKGROUND: Ischemic stroke that is sufficiently severe to cause loss of consciousness has a high rate of morbidity and mortality. Many individuals who suffer from these disorders never recover conscious awareness. In this study, we aimed to identify an accurate and simple bedside method to predict awareness recovery after severe acute ischemic stroke. METHODS: Between 2013 and 2017, all consecutive patients with consciousness disorders after acute ischemic stroke were recruited to the study...
December 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29243901/four-score-in-monitoring-the-level-of-consciousness-of-an-intensive-care-patient-first-experience-of-the-use-of-the-finnish-language-version
#19
Atte Sivula, Teemu Luoto, Jani Heinilä, Heini Huhtala, Sari Karlsson, Arvi Yli-Hankala, Jaakko Långsjö
BACKGROUND: The goal was to increase the knowledge of Full Outline of UnResponsiveness (FOUR) score in Finland, release its Finnish version and to evaluate its usefulness in Finnish ICU patients. MATERIALS AND METHODS: The highest FOUR and Glasgow Coma Scale (GCS) scores of the adult ICU patients treated in Tampere University Hospital between 1st January and 31st October 2015 were analyzed retrospectively. In-hospital and 1-month mortality were the primary end-points...
2017: Duodecim; Lääketieteellinen Aikakauskirja
https://www.readbyqxmd.com/read/29214444/the-respiratory-rate-a-neglected-triage-tool-for-pre-hospital-identification-of-trauma-patients
#20
John D Yonge, Phillip Kemp Bohan, Justin J Watson, Christopher R Connelly, Lynn Eastes, Martin A Schreiber
BACKGROUND: Under-triaged trauma patients have worse clinical outcomes. We evaluated the capability of four pre-hospital variables to identify this population at the lowest level trauma activation (level 3). METHODS: A retrospective review of adult trauma activations from 2004 to 2014 was completed. Pre-hospital vital signs and Glasgow Coma Scale were converted to categorical variables. Patients were under-triaged based on meeting current level 1 or 2 criteria, or requiring a pre-defined critical intervention...
December 6, 2017: World Journal of Surgery
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