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https://www.readbyqxmd.com/read/28177750/modulatory-role-of-co-enzyme-q10-on-methionine-and-choline-deficient-diet-induced-non-alcoholic-steatohepatitis-nash-in-albino-rats
#1
Dalia O Saleh, Rania F Ahmed, Mohamed M Amin
The present study aimed to evaluate the hepato-protective and neuro-protective activity of Co-enzyme Q10 (CoQ10) on non-alcoholic steatohepatitis (NASH) in albino rats induced by methionine and choline-deficient (MCD) diet. Rats were fed an MCD diet for 8 weeks to induce non-alcoholic steatohepatitis. CoQ10 (10 mg/(kg·day)(-1)) was orally administered for 2 consecutive weeks. Twenty-four hours after the last dose of the drug, the behavioral test, namely the activity cage test, was performed and the activity counts were recorded...
November 9, 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28114286/foxm1-recruits-nuclear-aurora-kinase-a-to-participate-in-a-positive-feedback-loop-essential-for-the-self-renewal-of-breast-cancer-stem-cells
#2
N Yang, C Wang, Z Wang, S Zona, S-X Lin, X Wang, M Yan, F-M Zheng, S-S Li, B Xu, L Bella, J-S Yong, E W-F Lam, Q Liu
Substantial evidence suggests that breast cancer initiation, recurrence and drug resistance is supported by breast cancer stem cells (BCSCs). Recently, we reported a novel role of Aurora kinase A (AURKA) in BCSCs, as a transactivating co-factor in the induction of the c-Myc oncoprotein. However, the mode of action and transcriptional network of nuclear AURKA in BCSCs remain unknown. Here, we report that nuclear AURKA can be recruited by Forkhead box subclass M1 (FOXM1) as a co-factor to transactivate FOXM1 target genes in a kinase-independent manner...
January 23, 2017: Oncogene
https://www.readbyqxmd.com/read/28107590/endocannabinoid-activation-of-cb1-receptors-contributes-to-long-lasting-reversal-of-neuropathic-pain-by-repetitive-spinal-cord-stimulation
#3
L Sun, L Tai, Q Qiu, R Mitchell, S Fleetwood-Walker, E A Joosten, C W Cheung
BACKGROUND: Spinal cord stimulation (SCS) has been shown to be effective in the management of certain neuropathic pain conditions, however, the underlying mechanisms are incompletely understood. In this study, we investigated repetitive SCS in a rodent neuropathic pain model, revealing long-lasting and incremental attenuation of hyperalgesia and a mechanism of action involving endocannabinoids. METHOD: Animals were implanted with monopolar electrodes at the time of partial sciatic nerve injury...
January 20, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28067873/cotransplantation-of-bone-marrow-derived-mesenchymal-stem-cells-in-haploidentical-hematopoietic-stem-cell-transplantation-in-patients-with-severe-aplastic-anemia-an-interim-summary-for-a-multicenter-phase-ii-trial-results
#4
Z Liu, Y Zhang, H Xiao, Z Yao, H Zhang, Q Liu, B Wu, D Nie, Y Li, Y Pang, Z Fan, L Li, Z Jiang, F Duan, H Li, P Zhang, Y Gao, L Ouyang, C Yue, M Xie, C Shi, Y Xiao, S Wang
Haploidentical hematopoietic stem cell transplantation (haplo-HSCT) for severe aplastic anemia (SAA) is mainly limited by the high incidence of graft failure and GvHD. Mesenchymal stem cells (MSCs) have been shown to support hematopoiesis in vivo and to display potent immunosuppressive effects to prevent or treat GvHD after HSCT. In a multicenter phase II trial, we developed an approach with co-transplantation of MSCs in patients undergoing haplo-HSCT. Forty-four patients with SAA were included. The conditioning regimen included busulfan, cyclophosphamide and thymoglobulin (ATG)...
January 9, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28064070/maspin-inhibits-macrophage-phagocytosis-and-enhances-inflammatory-cytokine-production-via-activation-of-nf-%C3%AE%C2%BAb-signaling
#5
Yimeng Wang, Luguo Sun, Zhenbo Song, Danfeng Wang, Yongli Bao, Yuxin Li
Maspin (mammary serine protease inhibitor) is a non-inhibitory member of the serine protease inhibitor superfamily and a tumor suppressor in several cancers due to its ability to inhibit cell invasion, angiogenesis, and promote apoptosis. However, its immunomodulatory function remains largely unexplored. Thus, we explored the potential link between Maspin and macrophage function, first evaluating the regulatory effects of conditioned medium (CM) of a Maspin-overexpressing CHO cell strain on mouse peritoneal macrophage phagocytosis and cytokine secretion...
January 5, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28051239/ex-vivo-expansion-of-antigen-specific-cd4-cd25-regulatory-t-cells-from-autologous-na%C3%A3-ve-cd4-t-cells-of-multiple-sclerosis-patients-as-a-potential-therapeutic-approach
#6
Y-J Xiang, M Ren, H Jiang, T-T Yang, Y He, D-H Ao, Y-Y Wang, Q Zhang, X-J He, X-G Gao, G-Z Liu
OBJECTIVE: CD4+CD25+ regulatory T cells (Tregs) have been found to have a decreased effector function in patients with multiple sclerosis (MS). In this study, we co-cultured naïve CD4+ T cells of MS patients with myelin basic protein (MBP)85-99 peptide as specific antigen and allogenic B cells as antigen-presenting cells, in an attempt to generate adequate antigen-specific CD4+CD25+ Tregs with normal or improved immune function. PATIENTS AND METHODS: Naïve CD4+ T cells were isolated from peripheral blood mononuclear cells (PBMCs) from patients with MS (n=5) and healthy controls (HC, n=5)...
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28048486/th-cd-bra-05-first-water-calorimetric-dw-measurement-and-direct-measurement-of-magnetic-field-correction-factors-kq-b-in-a-1-5-t-b-field-of-an-mri-linac
#7
L de Prez, J de Pooter, B Jansen, J Wolthaus, B van Asselen, S Woodings, T Soest, J Kok, B Raaymakers
PURPOSE: Reference dosimetry in MR-guided radiotherapy is performed in the presence of a B-field. As a consequence the response of ionization chambers changes considerably and depends on parameters not considered in traditional reference dosimetry. Therefore future Codes of Practices need ionization chamber correction factors to correct for both the change in beam quality and the presence of a B-field. The objective was to study the feasibility of water calorimetric absorbed-dose measurements in a 1...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047442/su-f-t-92-clinical-benefit-for-breast-and-chest-wall-setup-in-using-a-breast-board
#8
S Li, C Miyamoto, D Serratore, Q Liang, E Dziemianowicz
PURPOSE: To validate benefit of using a breast board (BB) by analyzing the geometry and dosimetry changes of the regions of interest (ROIs) between CT scans with and without BB. METHODS: Seven patients, two chest walls (CW) and five breasts, use BB at CT simulation and no BB at diagnostic CT were included. By using deformable image registration software (Velocity AI), diagnostic CT and planning CT were rigidly co-registered according to the thoracic cage at the target...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28043148/analysis-of-differentially-co-expressed-genes-based-on-microarray-data-of-hepatocellular-carcinoma
#9
Y Wang, T Jiang, Z Li, L Lu, R Zhang, D Zhang, X Wang, J Tan
Hepatocellular carcinoma (HCC) is the third leading cause of cancer related death worldwide. Although great progress in diagnosis and management of HCC have been made, the exact molecular mechanisms remain poorly understood. The study aims to identify potential biomarkers for HCC progression, mainly at transcription level. In this study, chip data GSE 29721 was utilized, which contains 10 HCC samples and 10 normal adjacent tissue samples. Differentially expressed genes (DEGs) between two samples types were selected by t-test method...
January 3, 2017: Neoplasma
https://www.readbyqxmd.com/read/28028033/interventions-for-preventing-cardiomyopathy-due-to-anthracyclines-a-bayesian-network-meta-analysis
#10
H Abdel-Qadir, G Ong, R Fazelzad, E Amir, D S Lee, P Thavendiranathan, G Tomlinson
BACKGROUND: The relative efficacy of interventions for primary prevention of anthracycline-associated cardiotoxicity is unknown. METHODS: We conducted a systematic review of randomized controlled trials for primary prevention of anthracycline-associated cardiotoxicity in adult cancer patients. We used hierarchal outcome definitions in the following order of priority: (1) composite of heart failure or decline in left ventricular ejection fraction, (2) decline in ejection fraction, or (3) heart failure...
December 26, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28004656/co-delivery-of-indoleamine-2-3-dioxygenase-prevents-loss-of-expression-of-an-antigenic-transgene-in-dystrophic-mouse-muscles
#11
D Sharma, R Al-Khalidi, S Edgar, Q An, Y Wang, C Young, D Nowis, D C Gorecki
A significant problem affecting gene therapy approaches aiming at achieving long-term transgene expression is the immune response against the protein product of the therapeutic gene, which can reduce or eliminate the therapeutic effect. The problem is further exacerbated when therapy involves targeting an immunogenic tissue and/or one with a pre-existing inflammatory phenotype, such as dystrophic muscles. In this proof-of-principle study, we co-expressed a model antigen, bacterial β-galactosidase, with an immunosuppressive factor, indoleamine 2,3-dioxygenase 1 (IDO1), in muscles of the mdx mouse model of Duchenne muscular dystrophy...
February 2017: Gene Therapy
https://www.readbyqxmd.com/read/28002581/investigation-on-the-association-between-il-10-c819t-gene-polymorphisms-and-susceptibility-to-gastric-cancer
#12
L Li, X Y Tang, L M Ye, Q Yang, Y Li
We conducted a case-control study to investigate the association between the interleukin-10 (IL-10) C819T polymorphism and susceptibility to gastric cancer in a Chinese population. A total of 157 patients with gastric cancer and 249 controls were consecutively enrolled from the Guizhou Provincial People's Hospital between October 2012 and February 2015. The polymerase chain reaction-restriction fragment length polymorphism technique was used to genotype for IL-10 C819T. As determined by χ(2)-test, there was a significant difference in genotype distributions of IL-10 C819T between gastric cancer patients and controls (χ(2) = 7...
December 19, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27988952/evidence-for-non-random-sampling-in-randomised-controlled-trials-by-yuhji-saitoh
#13
J B Carlisle, J A Loadsman
A large number of randomised trials authored by Yoshitaka Fujii have been retracted, in part as a consequence of a previous analysis finding a very low probability of random sampling. Dr Yuhji Saitoh co-authored 34 of those trials and he was corresponding author for eight of them. We found a number of additional randomised, controlled trials that included baseline data, with Saitoh as corresponding author, that Fujii did not co-author. We used Monte Carlo simulations to analyse the baseline data from 32 relevant trials in total as well as an outcome (muscle twitch recovery ratios) reported in several...
January 2017: Anaesthesia
https://www.readbyqxmd.com/read/27987878/interaction-and-formation-mechanism-of-binary-complex-between-zein-and-propylene-glycol-alginate
#14
Cuixia Sun, Lei Dai, Yanxiang Gao
The anti-solvent co-precipitation method was used to fabricate the zein-propylene glycol alginate (PGA) binary complex with different mass ratios of zein to PGA (20:1, 10:1, 5:1, 2:1 and 1:1) at pH 4.0. Results showed that attractive electrostatic interaction between zein and PGA occurred and negatively charged binary complex with large size and high turbidity was formed due to the charge neutralization. Hydrogen bonding and hydrophobic effects were involved in the interactions between zein and PGA, leading to the changed secondary structure and improved thermal stability of zein...
February 10, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27978931/-abnormal-expression-of-insulin-like-growth-factor-i-receptor-and-inhibitory-effect-of-its-transcription-intervention-on-nude-mice-xenograft-tumor
#15
M Yao, X D Yan, Y Cai, J J Gu, X L Yang, L H Pan, L Wang, D F Yao
Objective: To investigate the expression of insulin-like growth factor-I receptor (IGF-IR) in liver cancer and the inhibitory effect of its transcription intervention on nude mice xenograft tumor. Methods: A total of 40 patients with primary liver cancer were enrolled, and 40 samples of cancer lesions, peri-cancerous tissues (with a distance of 2 cm to the margin of cancer lesion), or distal liver tissues (with a distance of 5 cm to the margin of cancer lesion), with a weight of 200 mg, were collected after surgery...
November 20, 2016: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/27966835/the-epidemiology-and-characteristics-of-q-fever-and-co-infections-with-scrub-typhus-murine-typhus-or-leptospirosis-in-taiwan-a-nationwide-database-study
#16
C-H Lai, W Sun, C-H Lee, J-N Lin, M-H Liao, S-S Liu, T-Y Chang, K-F Tsai, Y-C Chang, H-H Lin, Y-H Chen
Q fever (QF) is a worldwide zoonosis associated with outbreaks. Only a few nationwide studies regarding the surveillance and epidemiology of human QF have been reported. Although QF is endemic in Taiwan, a nationwide database investigation of the epidemiology and characteristics of QF and its associations with scrub typhus (ST), murine typhus (MT) and leptospirosis (LS) has never been reported. We analysed nationwide databases of suspected QF, ST, MT and LS cases from October 2007 to December 2014 obtained from the Centers for Disease Control, Taiwan...
December 14, 2016: Zoonoses and Public Health
https://www.readbyqxmd.com/read/27914470/symptom-profiles-and-inflammatory-markers-in-moderate-to-severe-copd
#17
Huong Q Nguyen, Jerald R Herting, Kenneth C Pike, Sina A Gharib, Gustavo Matute-Bello, Soo Borson, Ruth Kohen, Sandra G Adams, Vincent S Fan
BACKGROUND: Physical and psychological symptoms are the hallmark of patients' subjective perception of their illness. The purpose of this analysis was to determine if patients with COPD have distinctive symptom profiles and to examine the association of symptom profiles with systemic biomarkers of inflammation. METHODS: We conducted latent class analyses of three physical (dyspnea, fatigue, and pain) and two psychological symptoms (depression and anxiety) in 302 patients with moderate to severe COPD using baseline data from a longitudinal observational study of depression in COPD...
December 3, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27903375/-in-vivo-and-in-vitro-effects-of-cd137-stimulation-on-vascular-calcification-in-high-fat-diet-fed-apoe-mice
#18
Y Chen, J C Yan, J Y Weng, Z Q Wang, C P Wang, C Shao
Objective: To investigate the effect and related mechanism of CD137 stimulation on aortic atherosclerotic plaque calcification in high fat diet fed ApoE(-/-) mice and on calcification of vascular smooth muscle cells (VSMCs). Methods: (1) ApoE(-/-) mice fed with high fat diet were randomly divided into 3 groups: CD137 activated group (treated by 200 μg CD137 agonist i. p. once per week for 6 weeks, n=5); CD137 inhibited group (anti-CD137 group: 200 μg anti-CD137 antibody + 200 μg CD137 agonist, i. p., once per week for 6 weeks, n=5) and control group (n=5)...
October 24, 2016: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/27893708/tgf-%C3%AE-upregulates-the-translation-of-usp15-via-the-pi3k-akt-pathway-to-promote-p53-stability
#19
W-T Liu, K-Y Huang, M-C Lu, H-L Huang, C-Y Chen, Y-L Cheng, H-C Yu, S-Q Liu, N-S Lai, H-B Huang
Crosstalk between transforming growth factor beta (TGF-β) signaling and p53 has a critical role in cancer progression. TGF-β signals via Smad and non-Smad pathways. Under normal conditions, wild-type p53 forms a complex with Smad2/3 and co-activates transcription of a variety of tumor suppressor genes, resulting in tumor suppressive effects. Thus, p53 stability is essential in progression of tumor suppressive responses mediated by TGF-β signaling. However, it remains unknown whether p53 stability is regulated by TGF-β...
November 28, 2016: Oncogene
https://www.readbyqxmd.com/read/27886426/retraction-statement-high-volumetric-performance-aligned-nano-porous-microwave-exfoliated-graphite-oxide-based-electrochemical-capacitors-and-aligned-nano-porous-microwave-exfoliated-graphite-oxide-ionic-actuators-with-high-strain-and-elastic-energy-density
#20
(no author information available yet)
These articles first published on 15 August 2013 and 21 August 2013 on the Wiley Online Library have been retracted at the request of the Research Integrity Officer (RIO) of The Pennsylvania State University, in agreement with the corresponding authors, the journal's Editor-in-Chief, and Wiley-VCH Verlag GmbH & Co. KGaA, because portions of the reported results cannot be considered reliable or reproducible. Following an investigation by the RIO of The Pennsylvania State University, it was found that the data in Figure 2a,b and Figure S1a,b (Supporting Information) of the article with DOI: 10...
2016: Advanced Materials
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