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https://www.readbyqxmd.com/read/27914470/symptom-profiles-and-inflammatory-markers-in-moderate-to-severe-copd
#1
Huong Q Nguyen, Jerald R Herting, Kenneth C Pike, Sina A Gharib, Gustavo Matute-Bello, Soo Borson, Ruth Kohen, Sandra G Adams, Vincent S Fan
BACKGROUND: Physical and psychological symptoms are the hallmark of patients' subjective perception of their illness. The purpose of this analysis was to determine if patients with COPD have distinctive symptom profiles and to examine the association of symptom profiles with systemic biomarkers of inflammation. METHODS: We conducted latent class analyses of three physical (dyspnea, fatigue, and pain) and two psychological symptoms (depression and anxiety) in 302 patients with moderate to severe COPD using baseline data from a longitudinal observational study of depression in COPD...
December 3, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27903375/-in-vivo-and-in-vitro-effects-of-cd137-stimulation-on-vascular-calcification-in-high-fat-diet-fed-apoe-mice
#2
Y Chen, J C Yan, J Y Weng, Z Q Wang, C P Wang, C Shao
Objective: To investigate the effect and related mechanism of CD137 stimulation on aortic atherosclerotic plaque calcification in high fat diet fed ApoE(-/-) mice and on calcification of vascular smooth muscle cells (VSMCs). Methods: (1) ApoE(-/-) mice fed with high fat diet were randomly divided into 3 groups: CD137 activated group (treated by 200 μg CD137 agonist i. p. once per week for 6 weeks, n=5); CD137 inhibited group (anti-CD137 group: 200 μg anti-CD137 antibody + 200 μg CD137 agonist, i. p., once per week for 6 weeks, n=5) and control group (n=5)...
October 24, 2016: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/27893708/tgf-%C3%AE-upregulates-the-translation-of-usp15-via-the-pi3k-akt-pathway-to-promote-p53-stability
#3
W-T Liu, K-Y Huang, M-C Lu, H-L Huang, C-Y Chen, Y-L Cheng, H-C Yu, S-Q Liu, N-S Lai, H-B Huang
Crosstalk between transforming growth factor beta (TGF-β) signaling and p53 has a critical role in cancer progression. TGF-β signals via Smad and non-Smad pathways. Under normal conditions, wild-type p53 forms a complex with Smad2/3 and co-activates transcription of a variety of tumor suppressor genes, resulting in tumor suppressive effects. Thus, p53 stability is essential in progression of tumor suppressive responses mediated by TGF-β signaling. However, it remains unknown whether p53 stability is regulated by TGF-β...
November 28, 2016: Oncogene
https://www.readbyqxmd.com/read/27886426/retraction-statement-high-volumetric-performance-aligned-nano-porous-microwave-exfoliated-graphite-oxide-based-electrochemical-capacitors-and-aligned-nano-porous-microwave-exfoliated-graphite-oxide-ionic-actuators-with-high-strain-and-elastic-energy-density
#4
(no author information available yet)
These articles first published on 15 August 2013 and 21 August 2013 on the Wiley Online Library have been retracted at the request of the Research Integrity Officer (RIO) of The Pennsylvania State University, in agreement with the corresponding authors, the journal's Editor-in-Chief, and Wiley-VCH Verlag GmbH & Co. KGaA, because portions of the reported results cannot be considered reliable or reproducible. Following an investigation by the RIO of The Pennsylvania State University, it was found that the data in Figure 2a,b and Figure S1a,b (Supporting Information) of the article with DOI: 10...
November 2016: Advanced Materials
https://www.readbyqxmd.com/read/27870644/analysis-of-physiological-respiratory-variable-alarm-alerts-among-laboring-women-receiving-remifentanil
#5
Carolyn F Weiniger, Brendan Carvalho, Daniel Stocki, Sharon Einav
BACKGROUND: Remifentanil may be used by laboring women for analgesia, despite controversy because of potential apneas. We evaluated candidate variables as early warning alerts for apnea, based on prevalence, positive predictive rate, sensitivity for apnea event detection, and early warning alert time intervals (lead time) for apnea. METHODS: We performed a secondary analysis of respiratory physiological data that had been collected during a prospective IRB-approved study of laboring women receiving IV patient-controlled boluses of remifentanil 20 to 60 μg every 1 to 2 minutes...
November 18, 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27837343/effect-of-preoperative-oral-analgesics-on-pulpal-anesthesia-in-patients-with-irreversible-pulpitis-a-systematic-review-and-meta-analysis
#6
REVIEW
Armin Shirvani, Sayna Shamszadeh, Mohammad Jafar Eghbal, Laleh Alim Marvasti, Saeed Asgary
OBJECTIVES: The objectives of this study were to assess the efficacy of preemptive oral administration of single dose of non-steroidal anti-inflammatory drugs (NSAIDs) and acetaminophen on the local anesthetic success in adults with irreversible pulpitis and to find the possible covariates that could predict treatment effect. MATERIALS AND METHODS: A systematic search using electronic databases up to March 2015 was conducted. Odds ratio (OR) and 95% confidence intervals (CIs) were estimated using random and fixed-effect inverse variance method...
November 11, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27836895/lifelong-quercetin-enrichment-and-cardioprotection-in-mdx-utrn-ice
#7
Christopher Ballmann, Thomas Denney, Ronald J Beyers, Tiffany S Quindry, Matthew Romero, Rajesh H Amin, Joshua T Selsby, John C Quindry
Duchenne Muscular Dystrophy (DMD) is associated with progressive cardiac pathology, however, the SIRT1/PGC1-α activator quercetin may cardioprotect dystrophic hearts. We tested the extent to which long term 0.2% dietary quercetin enrichment attenuates dystrophic cardiopathology in Mdx/Utrn(+/-) mice. At 2 months, Mdx/Utrn(+/-) mice were fed quercetin enriched (Mdx/Utrn(+/-)-Q) or control diet (Mdx/Utrn(+/-)) for 8 months. Control C57BL/10 (C57) animals were fed a control diet for 10 months. Cardiac function was quantified by MRI at 2 and 10 months...
November 11, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/27835000/identification-of-the-lowest-t-2-j-%C3%AF-0-isobaric-analog-state-in-52-co-and-its-impact-on-the-understanding-of-%C3%AE-decay-properties-of-52-ni
#8
X Xu, P Zhang, P Shuai, R J Chen, X L Yan, Y H Zhang, M Wang, Yu A Litvinov, H S Xu, T Bao, X C Chen, H Chen, C Y Fu, S Kubono, Y H Lam, D W Liu, R S Mao, X W Ma, M Z Sun, X L Tu, Y M Xing, J C Yang, Y J Yuan, Q Zeng, X Zhou, X H Zhou, W L Zhan, S Litvinov, K Blaum, G Audi, T Uesaka, Y Yamaguchi, T Yamaguchi, A Ozawa, B H Sun, Y Sun, A C Dai, F R Xu
Masses of ^{52g,52m}Co were measured for the first time with an accuracy of ∼10  keV, an unprecedented precision reached for short-lived nuclei in the isochronous mass spectrometry. Combining our results with the previous β-γ measurements of ^{52}Ni, the T=2, J^{π}=0^{+} isobaric analog state (IAS) in ^{52}Co was newly assigned, questioning the conventional identification of IASs from the β-delayed proton emissions. Using our energy of the IAS in ^{52}Co, the masses of the T=2 multiplet fit well into the isobaric multiplet mass equation...
October 28, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27828505/infrared-glass-based-negative-curvature-anti-resonant-fibers-fabricated-through-extrusion
#9
Rafael R Gattass, Daniel Rhonehouse, Daniel Gibson, Collin C McClain, Rajesh Thapa, Vinh Q Nguyen, Shyam S Bayya, R Joseph Weiblen, Curtis R Menyuk, L Brandon Shaw, Jasbinder S Sanghera
Negative curvature fibers have been gaining attention as fibers for high power infrared light. Currently, these fibers have been made of silica glass and infrared glasses solely through stack and draw. Infrared glasses' lower softening point presents the opportunity to perform low-temperature processing methods such as direct extrusion of pre-forms. We demonstrate an infrared-glass based negative curvature fiber fabricated through extrusion. The fiber shows record low losses in 9.75 - 10.5 µm range (which overlaps with the CO<sub>2</sub> emission bands)...
October 31, 2016: Optics Express
https://www.readbyqxmd.com/read/27799147/silencing-of-microrna-138-5p-promotes-il-1%C3%AE-induced-cartilage-degradation-in-human-chondrocytes-by-targeting-foxc1-mir-138-promotes-cartilage-degradation
#10
Y Yuan, G Q Zhang, W Chai, M Ni, C Xu, J Y Chen
OBJECTIVES: Osteoarthritis (OA) is characterised by articular cartilage degradation. MicroRNAs (miRNAs) have been identified in the development of OA. The purpose of our study was to explore the functional role and underlying mechanism of miR-138-5p in interleukin-1 beta (IL-1β)-induced extracellular matrix (ECM) degradation of OA cartilage. MATERIALS AND METHODS: Human articular cartilage was obtained from patients with and without OA, and chondrocytes were isolated and stimulated by IL-1β...
October 2016: Bone & Joint Research
https://www.readbyqxmd.com/read/27793397/prognostic-significance-of-ischemic-mitral-regurgitation-on-outcomes-in-acute-st-elevation-myocardial-infarction-managed-by-primary-percutaneous-coronary-intervention
#11
Amgad Mentias, Mohammad Q Raza, Amr F Barakat, Elizabeth Hill, Dalia Youssef, Amar Krishnaswamy, Milind Y Desai, Brian Griffin, Stephen Ellis, Venu Menon, E Murat Tuzcu, Samir R Kapadia
Ischemic mitral regurgitation (IMR) has been associated with worse outcome myocardial infarction. However, severity of mitral regurgitation (MR) and its impact on patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI) remains unknown. We sought to determine impact of increasing severity of IMR on outcomes in patients with STEMI undergoing primary PCI. All patients presenting with STEMI who underwent primary PCI within 12 hours of symptoms from 1994 to 2014 were included...
September 29, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27781340/p2x3-receptor-mediated-visceral-hyperalgesia-and-neuronal-sensitization-following-exposure-to-ptsd-like-stress-in-the-dorsal-root-ganglia-of-rats
#12
Y-Q He, X-Q Lang, L Lin, L Ji, X-Y Yuan, Q Chen, Y-M Ran, H-S Chen, L Li, J-M Wang, Z-G Wang, H Gregersen, D-W Zou, H-P Liang, M Yang
BACKGROUND: Patients with posttraumatic stress disorder (PTSD) often share co-morbidity with chronic pain conditions. Recent studies suggest a role of P2X3 receptors and ATP signaling in pain conditions. However, the underlying mechanisms of visceral hyperalgesia following exposure to PTSD-like stress conditions remain unclarified. METHODS: The behavior and hormones relevant for PTSD were studied. Visceromotor responses (VMR) and the abdominal withdrawal reflexes (AWR) to colorectal distention (CRD) were recorded to determine P2X3-receptor-mediated alteration of hyperalgesia following single-prolonged stress (SPS) exposure...
October 25, 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/27779250/the-preparation-of-rat-s-acellular-spinal-cord-scaffold-and-co-culture-with-rat-s-spinal-cord-neuron-in-vitro
#13
D-X Ban, Y Liu, T-W Cao, S-J Gao, S-Q Feng
STUDY DESIGN: The rat's acellular spinal cord scaffold (ASCS) and spinal cord neurons were prepared in vitro to explore their biocompatibility. OBJECTIVES: The preparation of ASCS and co-culture with neuron may lay a foundation for clinical treatment of spinal cord injury (SCI). SETTING: Tianjin Medical University General Hospital, ChinaMethods:ASCS was prepared by chemical extraction method. Hematoxylin and eosin (H&E), myelin staining and scanning electron microscope were used to observe the surface structure of ASCS...
October 25, 2016: Spinal Cord
https://www.readbyqxmd.com/read/27777423/characterization-and-transplantation-of-enteric-neural-crest-cells-from-human-induced-pluripotent-stem-cells
#14
W Li, L Huang, J Zeng, W Lin, K Li, J Sun, W Huang, J Chen, G Wang, Q Ke, J Duan, X Lai, R Chen, M Liu, Y Liu, T Wang, X Yang, Y Chen, H Xia, A P Xiang
The enteric nervous system (ENS) is recognized as a second brain because of its complexity and its largely autonomic control of bowel function. Recent progress in studying the interactions between the ENS and the central nervous system (CNS) has implicated alterations of the gut/brain axis as a possible mechanism in the pathophysiology of autism spectrum disorders (ASDs), Parkinson's disease (PD) and other human CNS disorders, whereas the underlying mechanisms are largely unknown because of the lack of good model systems...
October 25, 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/27764999/a-fatal-case-of-transplantation-mediated-alloimmune-thrombocytopenia-following-liver-transplantation
#15
Q A Hill, L C Harrison, A D Padmakumar, R G Owen, K R Prasad, G F Lucas, P Tachtatzis
OBJECTIVE AND IMPORTANCE: Transplantation-mediated alloimmune thrombocytopenia (TMAT) occurs when leukocytes transferred in a donor organ from a patient with immune thrombocytopenia (ITP), mount a response against recipient platelets. We present the first fatal case of TMAT following liver transplantation and review its aetiology and treatment. CLINICAL PRESENTATION: The liver donor had ITP and died from an intracranial haemorrhage. The recipient platelet count fell to 2 × 10(9)/l on post-operative day 2...
October 21, 2016: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/27729969/add-ons-in-ivf-programme-hype-or-hope
#16
A K Datta, S Campbell, B Deval, G Nargund
A series of new technologies and adjuvant therapies have been advocated in order to improve the success of IVF treatment. Dehydro-epiandrostenedione, growth hormones, Coenzyme Q 10, calcium ionosphores, immune therapy, heparin, low-dose aspirin, and vasodilators are among commonly prescribed pharmacological adjuvants. New technologies that are proposed to improve IVF outcomes include advanced sperm selection procedures, time- lapse embryo monitoring, preimplantation genetic screening, assisted hatching endometrial injury or embryo-glue...
December 28, 2015: Facts, Views & Vision in ObGyn
https://www.readbyqxmd.com/read/27691995/the-presence-of-fever-in-adults-with-influenza-and-other-viral-respiratory-infections
#17
A A Chughtai, Q Wang, T C Dung, C R Macintyre
We compared the rates of fever in adult subjects with laboratory-confirmed influenza and other respiratory viruses and examined the factors that predict fever in adults. Symptom data on 158 healthcare workers (HCWs) with a laboratory-confirmed respiratory virus infection were collected using standardized data collection forms from three separate studies. Overall, the rate of fever in confirmed viral respiratory infections in adult HCWs was 23·4% (37/158). Rates varied by virus: human rhinovirus (25·3%, 19/75), influenza A virus (30%, 3/10), coronavirus (28·6%, 2/7), human metapneumovirus (28·6%, 2/7), respiratory syncytial virus (14·3%, 4/28) and parainfluenza virus (8·3%, 1/12)...
January 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/27686765/-impact-of-pm2-5-on-daily-outpatient-numbers-for-respiratory-diseases-in-shenzhen-china
#18
C Q Peng, J F Cai, S Y Yu, Z J Cao, Y X Liao, N Liu, L He, L Zhang, J Zheng, X M Shi, J Q Cheng
Objective: To assess the association between the concentration of the air pollutant PM2.5 and daily outpatient visits for respiratory disease. Methods: All records of daily outpatient visits to three hospitals in Shenzhen from January 1 to December 31, 2013 were collected. Daily air pollution monitoring and meteorology data from the same period were also collected in Shenzhen. The data were analyzed using a semiparametric generalized additive model with Poisson distribution of time series analysis controlling for long-term and seasonal trends, flu, DOW, public holidays, and meteorological factors...
October 6, 2016: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/27671050/-analysis-of-clinical-and-pathological-characteristics-of-high-risk-hpv-negative-carcinoma-of-the-uterine-cervix
#19
Z M Li, L Q Zeng, X H Peng, L Z Mao, X L Sun, Y H Li, X P Luo
Objective: To study the clinical and pathological characteristics of HPV-negative cervical cancer patients. Methods: Retrospective analysis of 785 cervical cancer patients in Guangdong Women and Children Hospital from Jan. 2005 to Oct. 2015. By detecting high- risk HPV infection by flow-through hybridization genechip technique. Results: (1)Among 785 cases of cervical cancer, 71 cases were negative for HPV infection tested by genechip technique, accounting for 9.0%(71/785), and the relative light units/cut off(RLU/CO)ratios of these 71 cases were less than 1 by hybird capture Ⅱ(HC-Ⅱ)methods...
September 25, 2016: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/27666706/-experimental-study-on-substance-p-in-the-regulation-of-degranulation-of-cultured-murine-mast-cells
#20
F L Cheng, Q T Li, C Q Zhao, Y F An, X P Qi
Objective: To investigate the effect of interleukin-4 (IL-4) stimulation on the expression of FcεRⅠα and NK-1R on mature mast cells(MC) cultured and differentiated from mouse bone marrow stem cells, and then to study if these MC also respond to substance P (SP) both in FcεRⅠα and NK-1R dependent manners. Methods: Bone marrow cells were aseptically flushed from BALB/c mouse femurs into complete RPMI 1640, followed by culture with stem cell factor (SCF 100 μg/L), IL-3 (15 μg/L) and IL-4 (0, 10, 15, 20 and 25 μg/L, respectively)...
September 7, 2016: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
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