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Atrial fibrillaton

Karl Georg Haeusler, Paulus Kirchhof, Matthias Endres
Left atrial catheter ablation (LACA) has become an established therapy to abolish drug-refractory symptomatic paroxysmal and persistent atrial fibrillation. Restoring sinus rhythm by LACA may help to prevent atrial fibrillation-related strokes, but presently there is no evidence from randomized clinical trials to support this notion. This review summarizes the current knowledge and uncertainties regarding LACA and procedure-related ischemic stroke. In fact, most patients who undergo LACA have a rather low annual stroke risk even when left untreated, whereas LACA imposes a risk of procedure-related stroke of ≈0...
January 2012: Stroke; a Journal of Cerebral Circulation
Eric Schulze-Bahr, Paulus Kirchhof, Lars Eckardt, Jessica Bertrand, Günter Breithardt
Mild gender-specific differences in myocellular and invasive electrophysiology have been described recently. Importantly, the QT interval is slightly prolonged in women, when compared to men. In men atrial fibrillaton, preexcitation and ventricular tachycardia are found more often. Modifications of the cellular "milieu" come from hormonal factors and the autonomous nervous system. The interaction of theses influences with regional cellular factors will help us in the future to analyze gender-specific factors of arrhythmogenesis and develop treatment and prevention strategies...
August 2005: Herz
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