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Papilloma virus

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https://www.readbyqxmd.com/read/27902986/the-presence-of-hpv-dna-in-neck-lymph-node-metastasis-correlates-with-improved-overall-survival-of-patients-with-oropharyngeal-cancer-undergoing-surgical-treatment
#1
Eiji Shimura, Takanori Hama, Toshihito Suda, Masahiro Ikegami, Mitsuyoshi Urashima, Hiromi Kojima
BACKGROUND: Few studies have addressed how human papilloma virus (HPV) infection in oropharyngeal squamous cell carcinoma (OPSCC) affects the outcome of surgical therapy; furthermore, the relationship between the presence of HPV DNA and neck lymph node (LN) metastasis has not been well established. METHODS: A total of 65 patients who underwent surgery as a first-line therapy for OPSCC were enrolled in this study. In HPV-positive patients, the presence of HPV DNA in metastatic neck LN lesions was evaluated...
December 1, 2016: Oncology
https://www.readbyqxmd.com/read/27900000/involvement-of-tp53-and-tp16-expression-in-human-papillomavirus-associated-non-small-cell-lung-cancer
#2
Ming Li, Xiao-Lei Zhang, Fang Deng, Li-Ting Qian, Shui-Ping Meng, Wu-Lin Shan, Bao-Long Wang
Human papilloma virus (HPV) infection has previously been reported to be associated with TP53 and TP16 expression in Japanese and Taiwanese patients with lung cancer, but data for advanced non-small cell lung cancer (NSCLC) patients is limited. The present study examined the association between HPV infection and TP53 and TP16 expression in Chinese patients with advanced NSCLC. HPV DNA was detected in 20 out of 83 (24%) lung tumors, and was observed more frequently in non-smokers, patients with lymph node metastasis, and patients with poorly differentiated tumors (P=0...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27899988/mtor-downstream-effectors-4ebp1-and-eif4e-are-overexpressed-and-associated-with-hpv-status-in-precancerous-lesions-and-carcinomas-of-the-uterine-cervix
#3
Aristidis Asimomytis, Maria Karanikou, Alexander Rodolakis, Anna Vaiopoulou, Paraskevi Tsetsa, George Creatsas, Theodoros Stefos, Aristidis Antsaklis, Efstratios Patsouris, George Z Rassidakis
The present study aims to investigate the expression levels of two critical mammalian target of rapamycin (mTOR) downstream effectors, 4E binding protein 1 (4EBP1) and eukaryotic initiation factor 4E (eIF4E) proteins, in precancerous squamous intraepithelial lesions and cancer of the uterine cervix, and their association with human papilloma virus (HPV) infection status. Uterine cervical biopsies from 73 patients were obtained, including 40 fresh-frozen samples and 42 archival formalin-fixed, paraffin-embedded tissue specimens...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27898614/human-papilloma-virus-vaccination-and-incidence-of-ocular-surface-squamous-neoplasia
#4
Joy N Carroll, Zachary I Willis, Annabelle de St Maurice, Sahar Kohanim
No abstract text is available yet for this article.
2017: International Ophthalmology Clinics
https://www.readbyqxmd.com/read/27896883/curcumin-as-a-multifaceted-compound-against-human-papilloma-virus-infection-and-cervical-cancers-a-review-of-chemistry-cellular-molecular-and-preclinical-features
#5
REVIEW
Manouchehr Teymouri, Matteo Pirro, Thomas P Johnston, Amirhosein Sahebkar
Curcumin, the bioactive polyphenolic ingredient of turmeric, has been extensively studied for its effects on human papilloma virus (HPV) infection as well as primary and malignant squamous cervical cancers. HPV infections, especially those related to HPV 16 and 18 types, have been established as the leading cause of cervical cancer; however, there are also additional contributory factors involved in the etiopathogenesis of cervical cancers. Curcumin has emerged as having promising chemopreventive and anticancer effects against both HPV-related and nonrelated cervical cancers...
November 29, 2016: BioFactors
https://www.readbyqxmd.com/read/27896283/a-potential-founder-variant-in-carmil2-rltpr-in-three-norwegian-families-with-warts-molluscum-contagiosum-and-t-cell-dysfunction
#6
Hanne S Sorte, Liv T Osnes, Børre Fevang, Pål Aukrust, Hans C Erichsen, Paul H Backe, Tore G Abrahamsen, Ole B Kittang, Torstein Øverland, Shalini N Jhangiani, Donna M Muzny, Magnus D Vigeland, Pubudu Samarakoon, Tomasz Gambin, Zeynep H C Akdemir, Richard A Gibbs, Olaug K Rødningen, Robert Lyle, James R Lupski, Asbjørg Stray-Pedersen
BACKGROUND: Four patients from three Norwegian families presented with a common skin phenotype of warts, molluscum contagiosum, and dermatitis since early childhood, and various other immunological features. Warts are a common manifestation of human papilloma virus (HPV), but when they are overwhelming, disseminated and/or persistent, and presenting together with other immunological features, a primary immunodeficiency disease (PIDD) may be suspected. METHODS AND RESULTS: The four patients were exome sequenced as part of a larger study for detecting genetic causes of primary immunodeficiencies...
November 2016: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/27895921/literature-review-of-vaccine-related-adverse-events-reported-from-hpv-vaccination-in-randomized-controlled-trials
#7
Mohamed Macki, Ali A Dabaja
BACKGROUND: The human papilloma virus (HPV) infections were addressed with two FDA-approved HPV vaccines: quadrivalent and bivalent vaccine. The objective of this manuscript is to determine the safety of the HPV vaccine. RESULTS: A search of PubMed articles for "human papillomavirus vaccine" was used to identify all-type HPV clinical studies prior to October 2014. A refined search of clinical trials, multicenter studies, and randomized studies were screened for only randomized controlled trials comparing HPV vaccine to controls (saline placebo or aluminum derivatives)...
2016: Basic and Clinical Andrology
https://www.readbyqxmd.com/read/27894364/the-changing-landscape-of-oropharyngeal-cancer-management
#8
D Hamilton, M K Khan, J O'hara, V Paleri
BACKGROUND: Oropharyngeal cancer is increasing in prevalence in the UK and this is thought to be due to the emergence of disease related to human papilloma virus. METHOD: A literature review was conducted on the diagnosis and latest management of oropharyngeal cancer. RESULTS: In non-smokers, human papilloma virus related disease is thought to have better outcomes, but this casts doubt on previous research which did not stratify patients according to human papilloma virus status...
November 29, 2016: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/27894347/estimation-of-utility-weights-for-human-papilloma-virus-related-health-states-according-to-disease-severity
#9
Minsu Ock, Jeong-Yeol Park, Woo-Seung Son, Hyeon-Jeong Lee, Seon-Ha Kim, Min-Woo Jo
BACKGROUND: A cost-utility study of a human papilloma virus (HPV) vaccine requires that the utility weights for HPV-related health states (i.e., cervical intraepithelial neoplasia (CIN), cervical cancer, and condyloma) be evaluated. The aim of the present study was to determine the utility weights for HPV-related health states. METHODS: Hypothetical standardised health states related to HPV were developed based on patient education material and previous publications...
November 28, 2016: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/27891400/prevalence-of-human-papilloma-virus-infection-in-young-primiparous-women-during-postpartum-period-study-from-a-tertiary-care-center-in-northern-india
#10
Alpana Garg, Vanita Suri, Raje Nijhawan, Neelam Aggarwal, Ritu Aggarwal, Charu Guleria, Mili Thakur
INTRODUCTION: Assessment of high-risk Human Papilloma Virus (HPV) prevalence is important for monitoring long-term decrease in cervical cancer after implementation of the prophylactic HPV vaccination. AIM: To determine the prevalence of high-risk HPV infection and cytological abnormalities in young primiparous women in the age group of 16-26years. MATERIALS AND METHODS: In this cross-sectional study, 214 primiparous women aged 16-26years were recruited from a public tertiary health care center postpartum clinic between June 2013 and May 2014...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27889751/targeted-therapy-of-head-and-neck-cancer
#11
Damian T Rieke, Konrad Klinghammer, Ulrich Keilholz
Head and neck squamous cell carcinoma (HNSCC) is one of the most common solid cancers worldwide. It is mainly caused by exposure to tobacco smoke and alcohol as well as infection with the human papilloma virus (HPV). The prognosis is poor, especially once it recurs or metastasizes. Current therapeutic options include surgery, radio- and chemotherapy. Epidermal growth factor receptor (EGFR) inhibitors are so far the only targeted agents that have been approved in head and neck cancer. Primary or secondary resistance is frequent or will eventually develop...
2016: Oncology Research and Treatment
https://www.readbyqxmd.com/read/27889037/pathology-of-anal-cancer
#12
REVIEW
Paulo M Hoff, Renata Coudry, Camila Motta Venchiarutti Moniz
Anal canal cancer is rather an uncommon disease but its incidence is increasing. Squamous cell carcinoma (SCC) is the most frequent primary anal neoplasm and can encompass a variety of morphologies. HPV infection has a key role in precancerous lesions and cancer development by the production of E6 and E7 oncoproteins. Anal squamous precancerous lesions are now classified according to the same criteria and terminology as their cervical counterparts. The p16 expression by immunohistochemistry is a surrogate marker for human papilloma virus (HPV)...
January 2017: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/27889032/metastatic-anal-cancer-and-novel-agents
#13
REVIEW
Van Morris, Cathy Eng
Squamous cell carcinoma of the anal canal (SCCA) represents an orphan disease. Although prior infection with human papilloma virus is associated with the development of SCCA, knowledge of this relationship has proven ineffective in identifying therapeutic agents that have activity in the management of metastatic SCCA. Combination chemotherapy with traditional cytotoxic agents has demonstrated efficacy in multiple small series. However, immune checkpoint blockade agents have demonstrated efficacy for patients with refractory metastatic SCCA; these agents hold promise in the horizon for patients with metastatic SCCA...
January 2017: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/27884161/hpv16-integration-probably-contributes-to-cervical-oncogenesis-through-interrupting-tumor-suppressor-genes-and-inducing-chromosome-instability
#14
Jun-Wei Zhao, Fang Fang, Yi Guo, Tai-Lin Zhu, Yun-Yun Yu, Fan-Fei Kong, Ling-Fei Han, Dong-Sheng Chen, Fang Li
BACKGROUND: The integration of human papilloma virus (HPV) into host genome is one of the critical steps that lead to the progression of precancerous lesion into cancer. However, the mechanisms and consequences of such integration events are poorly understood. This study aims to explore those questions by studying high risk HPV16 integration in women with cervical intraepithelial neoplasia (CIN) and cervical squamous cell carcinoma (SCC). METHODS: Specifically, HPV integration status of 13 HPV16-infected patients were investigated by ligation-mediated PCR (DIPS-PCR) followed by DNA sequencing...
November 25, 2016: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/27882102/inhibition-of-antiviral-drug-cidofovir-on-proliferation-of-human-papillomavirus-infected-cervical-cancer-cells
#15
Jing Yang, Lv-Xia Dai, Ming Chen, Bei Li, Nana Ding, Gang Li, Yan-Qing Liu, Ming-Yuan Li, Bao-Ning Wang, Xin-Li Shi, Hua-Bing Tan
In order to evaluate the potential application value of cidofovir (CDV) in the prevention of human papillomavirus (HPV) infection and treatment of cervical cancer, the inhibitory effect of CDV on the proliferation of HPV 18-positive HeLa cells in cervical cancer was preliminarily investigated, using cisplatin (DDP) as a positive control. An MTT assay was used to analyze the effects of CDV and DDP on HeLa cell proliferation. In addition, clone formation assay and Giemsa staining were used to examine the extent of HeLa cell apoptosis caused by CDV and DDP...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27872541/splenic-metastasis-from-cancer-of-uterine-cervix-a-rare-case
#16
Jagannath Dixit, Noor Mohammed, Preethi Shetty
Cancer of uterine cervix is one of the most common malignancies in women. Metastatic recurrence of cervical cancer in spleen is rare, mostly seen in autopsies. Splenic metastasis from cervical cancer in a living patient without disseminated metastases is rarer. Here, we present the case of a lady aged 46 years with cervical cancer-squamous cell carcinoma-who had undergone radical hysterectomy and postoperative 50 Gy of intensity modulated radiation therapy in 25 fractions and 50 mg of weekly cisplatin for 6 weeks...
December 2016: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27872524/human-papilloma-virus-in-oral-cavity-cancer-and-relation-to-change-in-quality-of-life-following-treatment-a-pilot-study-from-northern-india
#17
Abhishek Kumar Singh, Jitendra Kumar Kushwaha, Akshay Anand, Abhinav Arun Sonkar, Nuzhat Husain, Kirti Srivastava, Sudhir Singh
Human papilloma virus (HPV)-associated head and neck cancer (HNC) has generated significant amount of research interest in recent times with focus shifted to oral cavity squamous cell cancer (OCSCC) after oropharyngeal cancer. Due to high incidence of OCSCC and anecdotal reports on association of HPV infection from northern region of India, this study was conceived to investigate HPV infection and establish its association with lifestyle habits such as tobacco, alcohol consumption, oro-genital sex, number of sexual contacts, and change in quality of life posttreatment...
December 2016: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27872202/genome-wide-overexpression-screen-identifies-genes-able-to-bypass-p16-mediated-senescence-in-melanoma
#18
Won Jae Lee, Dubravka Škalamera, Mareike Dahmer-Heath, Konstanin Shakhbazov, Max V Ranall, Carly Fox, Duncan Lambie, Alexander J Stevenson, Paul Yaswen, Thomas J Gonda, Brian Gabrielli
Malignant melanomas often arise from nevi, which result from initial oncogene-induced hyperproliferation of melanocytes that are maintained in a CDKN2A/p16-mediated senescent state. Thus, genes that can bypass this senescence barrier are likely to contribute to melanoma development. We have performed a gain-of-function screen of 17,030 lentivirally expressed human open reading frames (ORFs) in a melanoma cell line containing an inducible p16 construct to identify such genes. Genes known to bypass p16-induced senescence arrest, including the human papilloma virus 18 E7 gene (HPV18E7), and genes such as the p16-binding CDK6 with expected functions, as well as panel of novel genes, were identified, including high-mobility group box (HMGB) proteins...
November 21, 2016: Journal of Biomolecular Screening
https://www.readbyqxmd.com/read/27872102/e6-and-e7-antibody-levels-are-potential-biomarkers-of-recurrence-in-patients-with-advanced-stage-human-papillomavirus-positive-oropharyngeal-squamous-cell-carcinoma
#19
Matthew E Spector, Assutina G Sacco, Emily L Bellile, Jeremy M G Taylor, Tamara R Jones, Kan Sun, William C Brown, Andrew C Birkeland, Carol R Bradford, Gregory T Wolf, Mark E Prince, Jeffrey S Moyer, Kelly M Malloy, Paul Swiecicki, Avraham Eisbruch, Jonathan B McHugh, Douglas B Chepeha, Laura S Rozek, Francis P Worden
PurposeThere is a paucity of biomarkers to predict failure in human papilloma-virus positive (HPV+) oropharyngeal squamous cell carcinoma (OPSCC) following curative therapy. E6/E7 viral oncoproteins are constitutively expressed in HPV+ tumors and highly immunogenic, resulting in readily detected serum antibodies. The purpose of this study is to determine if serum E6 and E7 antibody levels can potentially serve as a biomarker of recurrence in patients with HPV+OPSCC. Experimental DesignWe evaluated E6/E7 antibody levels in patients with previously untreated, advanced stage(III, IVa-b), HPV+OPSCC receiving definitive chemoradiation under a uniform protocol from 2003-2010...
November 21, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27867303/dna-methylation-of-cellular-retinoic-acid-binding-proteins-in-cervical-cancer
#20
Ana L Arellano-Ortiz, Mauricio Salcedo-Vargas, Claudia L Vargas-Requena, José A López-Díaz, Antonio De la Mora-Covarrubias, Juan C Silva-Espinoza, Florinda Jiménez-Vega
This study determined the methylation status of cellular retinoic acid-binding protein (CRABP) gene promoters and associated them with demographic characteristics, habits, and the presence of human papilloma virus (HPV) in patients with cervical cancer (CC), low and high squamous intraepithelial lesions, and no intraepithelial lesion. Women (n = 158) were selected from the Colposcopy Clinic of Sanitary Jurisdiction II in Ciudad Juarez, Chihuahua, Mexico. Demographic characteristics and habit information were collected...
2016: Genetics & Epigenetics
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