Read by QxMD icon Read


Jingjing He, Zheng Xiang, Xiaoqing Zhu, Zongyong Ai, Jingsong Shen, Tianzhuang Huang, Liegang Liu, Weizhi Ji, Tianqing Li
Parkinson's disease (PD) is one common neurodegenerative disease caused by a significant loss of midbrain dopaminergic neurons. Previous reports showed that 7, 8- dihydroxyflavone (7, 8-DHF) as a potent TrkB agonist can mimic BDNF and play neuroprotective roles for mouse dopaminergic neurons. Nonetheless, the safety and neuroprotective effects are unclear in monkey models of PD. Here, we find that 7, 8-DHF could be absorbed and metabolized into 7-hydroxy-8-methoxyflavone through oral administration in monkeys...
October 12, 2016: Scientific Reports
Larissa G Faqueti, Vincent Brieudes, Maria Halabalaki, Alexios L Skaltsounis, Leandro F Nascimento, Wellinghton M Barros, Adair R S Santos, Maique W Biavatti
ETHNOPHARMACOLOGICAL RELEVANCE: Ageratum conyzoides L. is a plant widely used in traditional medicine in tropical and subtropical regions of the world due to its anti-inflammatory, antinociceptive and antibacterial properties. AIM OF THE STUDY: To characterize the standardized extract of polymethoxyflavones (SEPAc) from the plant and evaluate its antinociceptive and anti-inflammatory effects. MATERIALS AND METHODS: The SEPAc purified from the ethanol extract of the plant leaves was characterized by high resolution mass spectrometry and the methoxyflavones were quantified by a validated UPLC-PDA method...
September 12, 2016: Journal of Ethnopharmacology
Aymé Fernández-Calienes Valdés, Lianet Monzote Fidalgo, Idalia Sariego Ramos, David Marrero Delange, Carmen Luisa Morales Rico, Judith Mendiola Martínez, Armando Cuéllar Cuéllar
CONTEXT: Scutellaria havanensis Jacq. (Lamiaceae) is a native medicinal herb with a history of use in Cuba. OBJECTIVE: This study screens the antiprotozoal activity of S. havanensis. MATERIALS AND METHODS: Chloroform and methanol extracts from leaves and stems were evaluated in vitro at doses between 0.015 and 200 μg/mL against protozoan parasites: Plasmodium berghei, Trichomonas vaginalis and Leishmania amazonensis. Chloroform and methanol extracts were characterized by GC/MS...
August 26, 2016: Pharmaceutical Biology
Bin Huang, Hongyi Liu, Dongliang Huang, Xuhua Mao, Xianyun Hu, Caiyun Jiang, Maomao Pu, Gen Zhang, Xin Zeng
Wogonin (5,7-dihydroxy-8-methoxyflavone) is one of the active components of flavonoids isolated from Scutellariae radix and possesses antitumor effect against leukemia. Cadmium-telluride quantum dots (CdTe-QDs) are a kind of nanoparticles with great potential in functioning as an efficient drug delivery vector in biomedical research. In this study, we investigated the synergistic effect of CdTe-QDs with Wogonin on the induction of apoptosis using drug-resistant human leukemia KA cells. Flow cytometry analysis, assay of morphology under electron microscope, quantitative analysis of tumor volume and micro-CT imaging demonstrated that compared with that by pure CdTe-QDs or wogonin, the apoptosis rate increased sharply when treated wirh CdTe-QDs together with wogonin on KA cells...
March 2016: Journal of Nanoscience and Nanotechnology
Bin Li, Yong Zhang, Wen-peng Du, Hong-dong Liu, Bo Liu, Xue-wen Lai, Peng Xu
OBJECTIVE: To investigate the chemical constituents from the shoot of Phyllostachys edulis. METHODS: Normal-phase, reversed-phase silica gel, Sephadex LH-20 porous polymer gel column and HPLC chromatography were used for isolation. Spectroscopic methods (13C-NMR, 1H-NMR, DEPT and EI-MS) were used for identification. RESULTS: Eleven compounds were isolated and elucidated, which were skimmin(I), liquiritienin(II),1-(4-hydroxy-3-methoxyphenyl)-1-propanone(III), syringicaldehyde(IV), vanillin(V), isoliquiritigenin(VI), 4-hydroxybenzoic acid(VII), methyl p-hydroxy benzeneacetate (VIII), 5,7-dihydroxy-8-methoxyflavone (IX), daucosterol(X) and β-sitosterol(X)...
December 2015: Zhong Yao Cai, Zhongyaocai, Journal of Chinese Medicinal Materials
Jyotsna Asthana, B N Mishra, Rakesh Pandey
The progression in lifespan has been associated with elevated intracellular reactive oxygen species (ROS) and oxidative stress level which contributes to development of age related disorders. The discovery of lifespan modulating phytomolecules may promote development of natural therapies against age related afflictions. Acacetin (5,7-dihydroxy-4-methoxyflavone), is a naturally occurring flavonoid known to possess therapeutic properties. To this end, the present study evaluates effect of acacetin (AC) on lifespan, stress and neurotoxicity for the first time by using well-established free living, multicellular Caenorhabditis elegans model system...
August 2016: Free Radical Research
Yung-Yi Cheng, Tung-Hu Tsai
Rhodamine B is an illegal and potentially carcinogenic food dye. The aim of this study was to develop a convenient, rapid, and sensitive UHPLC-MS/MS method for pharmacokinetic studies in rats. Rat plasma samples were deproteinized with acetonitrile and separated by UHPLC on a reverse-phase C18e column (100mm×2.1mm, 2μm) using a mobile phase consisting of methanol-5mM ammonium acetate (90:10, v/v). Detection was performed using a triple quadrupole tandem mass spectrometer in the selected reaction monitoring mode at [M](+) ion m/z 443...
June 5, 2016: Journal of Pharmaceutical and Biomedical Analysis
Monika Bhardwaj, Na-Hyung Kim, Souren Paul, Rekha Jakhar, Jaehong Han, Sun Chul Kang
Plant-derived compounds are an important source of clinically useful anti-cancer agents. Chrysin, a biologically active flavone found in many plants, has limited usage for cancer chemotherapeutics due to its poor oral bioavailability. 5-Hydroxy-7-methoxyflavone (HMF), an active natural chrysin derivative found in various plant sources, is known to modulate several biological activities. However, the mechanism underlying HMF-induced apoptotic cell death in human colorectal carcinoma cells in vitro is still unknown...
2016: PloS One
Junei Kinjo, Daisuke Nakano, Toshihiro Fujioka, Hikaru Okabe
Over the course of our studies investigating anti-proliferative properties of compounds originating from plants against human gastric adenocarcinoma (MK-1), human uterine carcinoma (HeLa), murine melanoma (B16F10), and two human T cell lymphotropic virus type 1 (HTLV-1)-infected T-cell lines (MT-1 and MT-2), we have screened 582 extracted samples obtained from a variety of parts from 370 plants. A few extracts showed anti-proliferative activity against all cell lines, but upon further investigation, toxicity toward selected cell lines was recognized...
July 2016: Journal of Natural Medicines
Fuqiang Li, Xiang Li, Yunjie Miao, Chenxiao Shan, Fei Yuan, Chengyao Ma, Qiwen Wang, Jianwei Chen, Yong Chen
Although some physiological and pathological function parameters of hepatitis and liver cancer have been investigated in relation to hispidulin (5,7,4'-trihydroxy-6-methoxyflavone), the changes of small metabolites in biofluids have been reported rarely. Recent research has shown that metabolic profiling with ultra-high-performance liquid chromatography coupled to quadrupole time of flight mass spectrometry (UHPLC-QTOF/MS) coupled with multivariate statistical analysis provides a good understanding of hispidulin effects on mice vaccinated intraperitoneally with H22 tumor cells...
June 5, 2016: Journal of Pharmaceutical and Biomedical Analysis
Lorena M C Cursino, Nerilson M Lima, Renato Murillo, Cecilia V Nunez, Irmgard Merfort, Matjaz Humar
Preparations of Deguelia duckeana, known in Brazil as timbó, are used by indigenous people to kill fish. Reinvestigation of its extracts resulted in the isolation and identification of 11 known flavonoids identified as 3,5,4'-trimethoxy-4-prenylstilbene (1), 4-methoxyderricidine (2), lonchocarpine (3), 4-hydroxylonchocarpine (4), 4-methoxylonchocarpine (5), 5-hydroxy-4',7-dimethoxy-6-prenylflavanone (6), 4'-hydroxyisolonchocarpine (7), 4'-methoxyisolonchocarpine (8), 3',4',7-trimethoxyflavone (9), 3',4'-methylenedioxy-7-methoxyflavone (10), and 2,2-dimethyl-chromone-5,4'-hydroxy-5'-methoxyflavone (11)...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Varsha S Honmore, Amit D Kandhare, Parag P Kadam, Vijay M Khedkar, Dhiman Sarkar, Subhash L Bodhankar, Anand A Zanwar, Supada R Rojatkar, Arun D Natu
BACKGROUND: Inflammation triggered by oxidative stress can cause various ailments, such as cancer, rheumatoid arthritis, asthma, diabetes etc. In the last few years, there has been a renewed interest in studying the antioxidant and anti-inflammatory action of plant constituents such as flavonoids and diarylheptanoids. AIM: To evaluate the antioxidant, anti-inflammatory activity and the total phenolic content of isolated compounds from Alpinia officinarum rhizomes...
April 2016: International Immunopharmacology
Po-Jung Tsai, Wen-Cheng Huang, Ming-Chi Hsieh, Ping-Jyun Sung, Yueh-Hsiung Kuo, Wen-Huey Wu
Scutellariae radix, the root of Scutellaria baicalensis, has long been applied in traditional formulations and modern herbal medications. Propionibacterium acnes (P. acnes) in follicles can trigger inflammation and lead to the symptom of inflammatory acnes vulgaris. This study was aimed at evaluating the effect of Scutellariae radix extract and purified components isolated from it on inflammation induced by P. acnes in vitro and in vivo. The results showed the ethyl acetate (EA) soluble fraction from the partition of crude ethanolic extract from Scutellariae radix inhibited P...
2015: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Kiyofumi Ninomiya, Taku Matsumoto, Saowanee Chaipech, Sohachiro Miyake, Yushi Katsuyama, Akihiro Tsuboyama, Yutana Pongpiriyadacha, Takao Hayakawa, Osamu Muraoka, Toshio Morikawa
A methanol extract from the rhizomes of Kaempferia parviflora Wall. ex Baker (Zingiberaceae) has shown inhibitory effects against melanogenesis in theophylline-stimulated murine B16 melanoma 4A5 cells (IC50 = 9.6 μg/mL). Among 25 flavonoids and three acetophenones isolated previously (1-28), several constituents including 5-hydroxy-7,3',4'-trimethoxyflavone (6, IC50 = 8.8 μM), 5,7,3',4'-tetramethoxyflavone (7, 8.6 μM), 5,3'-dihydroxy-3,7,4'-trimethoxyflavone (12, 2.9 μM), and 5-hydroxy-3,7,3',4'-tetramethoxyflavone (13, 3...
April 2016: Journal of Natural Medicines
Wenzhe Ma, Senling Feng, Xiaojun Yao, Zhongwen Yuan, Liang Liu, Ying Xie
Multidrug resistance (MDR) is the major obstacle to the successful chemotherapy treatment of many cancers. Here we found that nobiletin, a citrus methoxyflavone, significantly sensitized ABCB1 overexpressing cells A2780/T and A549/T to chemotherapeutic agents such as paclitaxel (a 433-fold reversal of MDR to PTX at 9 μM), doxorubicin (DOX), docetaxel and dounorubicin. Nobiletin profoundly inhibited ABCB1 transporter activity since it significantly increased the intracellular accumulation of DOX and Flutax-2 in A2780/T cells and decreased the efflux of ABCB1 substrates in Caco2 cells without altering the mRNA and protein expression of ABCB1...
2015: Scientific Reports
Raymond N Nono, Elvine P Nguelefack-Mbuyo, Laurence K Nzowa, Beaudelaire K Ponou, Rémy B Teponno, Télesphore B Nguelefack, Luciano Barboni, Léon A Tapondjou, Hee-Juhn Park
A new C-glycosylflavone, drymaritin E (6-C-(3-keto-β-digitoxopyranosyl)-4'-O-(β-D-glucopyranosyl)-7-methoxyl-5,4'-dihydroxylflavone) 1 was isolated from the oily upper phase (SU) of the MeOH extract from aerial parts of Drymaria cordata together with two known compounds (cassiaoccidentalin A 2 and anemonin 3) and an inseparable mixture of two known C-glycosylflavones 5,4'-dihydroxy-7-methoxyflavone-6-C-(2''-O-α-L-rhamnopyranosyl)-β-D-glucopyranoside 4a and 5,7,3',4'-tetrahydroxyflavone-6-C-(2''-O-α-L-rhamnopyranosyl)-β-D-glucopyranoside 4b...
January 2016: Archives of Pharmacal Research
Kazuya Toda, Shogo Takeda, Shoketsu Hitoe, Seikou Nakamura, Hisashi Matsuda, Hiroshi Shimoda
Enhancement of muscular energy production is thought to improve locomotive functions and prevent metabolic syndromes including diabetes and lipidemia. Black ginger (Kaempferia parviflora) has been cultivated for traditional medicine in Thailand. Recent studies have shown that black ginger extract (KPE) activated brown adipocytes and lipolysis in white adipose tissue, which may cure obesity-related dysfunction of lipid metabolism. However, the effect of KPE on glucose and lipid utilization in muscle cells has not been examined yet...
April 2016: Journal of Natural Medicines
Kazuya Ito, Mai Matsuzaki, Tomoya Sasahara, Mariko Shin, Katsutoshi Yayama
Orthovanadate (OVA), a protein tyrosine phosphatase inhibitor, induces vasoconstriction in a Rho kinase-dependent manner. The aim of this study was to determine the mechanism underlying OVA-induced vasoconstriction of rat mesenteric arteries. OVA-induced constriction of mesenteric arterial rings treated with N(G)-nitro-L-arginine methyl ester (L-NAME, 0.1 mM), a nitric oxide synthase inhibitor, was significantly blocked by the Rho kinase inhibitor Y-27632 (R-(+)-trans-N-(4-pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide, 10 µM), extracellular signal-regulated kinase 1 and 2 (Erk1/2) inhibitor FR180204 (5-(2-phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine, 10 µM), Erk1/2 kinase (MEK) inhibitor PD98059 (2'-amino-3'-methoxyflavone, 10 µM), epidermal growth factor receptor (EGFR) inhibitor AG1478 (4-(3-chloroanilino)-6,7-dimethoxyquinazoline, 10 µM), and Src inhibitor PP2 (4-amino-3-(4-chlorophenyl)-1-(t-butyl)-1H-pyrazolo[3,4-d]pyrimidine, 3 µM)...
2015: Biological & Pharmaceutical Bulletin
Oscar Díaz, Rosana Alarcón, Diego Gutiérrez, Adriana Pacciaroni, Fany Cayo, Virginia Sosa
The flower heads of Microliabum polymnioides afforded scopoletin, 5,4'-dihydroxy-3,6,7-trimethoxyflavone, 3,5,4'-trihydroxy-6,7-dimethoxyflavone and 3,5,7,4'-tetrahydroxy-6-methoxyflavone. The leaves contained hexadecanoic acid, phytol and docosane. This is the first report on the presence of 6-methoxyflavonoids in Microliabum genus.
July 2015: Natural Product Communications
Yueqiu Liu, Dan Staerk, Mia N Nielsen, Nils Nyberg, Anna K Jäger
Inhibition of the necrotizing hyaluronidase, phospholipase A2 and protease enzymes in four snake venoms by crude water and ethanol extracts of 88 plant species used against snakebites in traditional Chinese medicine was measured. High-resolution hyaluronidase inhibition profiles were constructed for the 22 plants showing highest hyaluronidase inhibition, and the results were used to guide subsequent structural analysis towards specific hyaluronidase inhibitors. Structural analysis was performed by high-performance liquid chromatography, high-resolution mass spectrometry, solid-phase extraction and nuclear magnetic resonance spectroscopy, i...
November 2015: Phytochemistry
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"