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https://www.readbyqxmd.com/read/29352103/dynamic-cycling-of-t-snare-acylation-regulates-platelet-exocytosis
#1
Jinchao Zhang, Yunjie Huang, Jing Chen, Haining Zhu, Sidney W Whiteheart
Platelets regulate vascular integrity by secreting a host of molecules that promote hemostasis and its sequelae. Given the importance of platelet exocytosis, it is critical to understand how it is controlled. The t-SNAREs, SNAP-23 and syntaxin-11, lack classical transmembrane domains (TMDs), yet both are associated with platelet membranes and redistributed into cholesterol-dependent, lipid rafts when platelets were activated. Using metabolic labeling and hydroxylamine/HCl (HA) treatment, we showed that both contain thioester-linked acyl groups...
January 19, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29351877/rest-a-master-transcriptional-regulator-in-neurodegenerative-disease
#2
REVIEW
Jee-Yeon Hwang, R Suzanne Zukin
The restrictive element-1 silencing transcription factor)/NRSF (neuron-restrictive silencing factor (NRSF) is a transcriptional repressor which acts via epigenetic remodeling to silence target genes. Emerging evidence indicates that REST is a master transcriptional regulator of neuron-specific genes not only in neurogenesis and neuronal differentiation, but also in differentiated neurons during the critical period in postnatal brain development, where it plays a role in fine-tuning of genes involved in synaptic plasticity, and in normal aging, where it promotes neuroprotection by repressing genes involved in oxidative stress and β-amyloid toxicity...
January 16, 2018: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/29351410/hypoxia-selectively-upregulates-cation-channels-and-increases-cytosolic-ca2-in-pulmonary-but-not-coronary-arterial-smooth-muscle-cells
#3
Xi He, Shanshan Song, Ramon J Ayon, Angela Balisterieri, Stephen M Black, Ayako Makino, W Gil Wier, Wei-Jin Zang, Jason X-J Yuan
Ca2+ signaling, particularly the mechanism via store-operated Ca2+ entry (SOCE) and receptor-operated Ca2+ entry (ROCE), plays a critical role in the development of acute hypoxia-induced pulmonary vasoconstriction and chronic hypoxia-induced pulmonary hypertension. This study aimed to test the hypothesis that chronic hypoxia differentially regulates the expression of proteins that mediate SOCE and ROCE (STIM, Orai, and TRPC6) in pulmonary (PASMC) and coronary (CASMC) artery smooth muscle cells. The resting cytosolic [Ca2+] ([Ca2+]cyt) and the stored [Ca2+] in the sarcoplasmic reticulum (SR) were not different in CASMC and PASMC...
January 3, 2018: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/29350187/multifractal-dynamics-of-resting-state-functional-connectivity-in-the-prefrontal-cortex
#4
Frigyes Samuel Racz, Peter Mukli, Zoltan Nagy, Andras Eke
Brain function is organized as a network of functional connections between different neuronal populations with connection strengths dynamically changing in time and space. Studies investigating functional connectivity (FC) usually follow a static approach when describing FC by considering the connectivity strengths constant, however a dynamic approach seems more reasonable, as this way the spatio-temporal dynamics of the underlying system can also be captured. Objective: The scale-free, i.e. fractal nature of neural dynamics is an inherent property of the nervous system...
January 19, 2018: Physiological Measurement
https://www.readbyqxmd.com/read/29343732/the-neural-correlates-of-the-unified-percept-of-alcohol-related-craving-a-fmri-and-eeg-study
#5
Yuefeng Huang, Anusha Mohan, Dirk De Ridder, Stefan Sunaert, Sven Vanneste
Alcohol addiction is accompanied by aberrant neural activity. Previously, task-based fMRI and resting-state EEG studies have revealed that craving, a critical component of addiction, is linked to abnormal activity in cortical regions including the dorsal anterior cingulate cortex (dACC), nucleus accumbens (NAcc), posterior cingulate cortex (PCC) and pregenual anterior cingulate cortex (pgACC), etc. In this study, we combine these two imaging techniques to investigate a group of alcohol-addicted patients and provide convergent evidence for the neural correlates of craving not only in alcohol but substance abuse in general...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29343596/daphnia-invest-in-sexual-reproduction-when-its-relative-costs-are-reduced
#6
Nina Gerber, Hanna Kokko, Dieter Ebert, Isobel Booksmythe
The timing of sex in facultatively sexual organisms is critical to fitness, due to the differing demographic consequences of sexual versus asexual reproduction. In addition to the costs of sex itself, an association of sex with the production of dormant life stages also influences the optimal use of sex, especially in environments where resting eggs are essential to survive unfavourable conditions. Here we document population dynamics and the occurrence of sexual reproduction in natural populations of Daphnia magna across their growing season...
January 31, 2018: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29343082/systematic-review-of-the-effect-of-adherence-to-statin-treatment-on-critical-cardiovascular-events-and-mortality-in-primary-prevention
#7
Eva Martin-Ruiz, Antonio Olry-de-Labry-Lima, Ricardo Ocaña-Riola, David Epstein
AIM: Analyze the relative risks of critical cardiovascular outcomes and mortality associated with adherence to statin treatment in a clinical setting in people with no history of prior cardiovascular disease (CVD). METHODS: A systematic review of the literature was conducted up to December 2016. The outcomes of interest were cardiovascular fatal or nonfatal events and all-cause mortality. RESULTS: A total of 17 articles were included in a qualitative synthesis...
January 1, 2018: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29342996/-optimal-energy-supply-in-different-age-groups-of-critically-ill-children-on-mechanical-ventilation
#8
X H Li, J Ji, S Y Qian
Objective: To analyze the resting energy expenditure and optimal energy supply in different age groups of critically ill children on mechanical ventilation in pediatric intensive care unit (PICU). Methods: Patients on mechanical ventilation hospitalized in PICU of Beijing Children's Hospital from March 2015 to March 2016 were enrolled prospectively. Resting energy expenditure of patients was calculated by US Med Graphic company critical care management (CCM) energy metabolism test system after mechanical ventilation...
January 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29341331/the-relationship-between-thalamic-gaba-content-and-resting-cortical-rhythm-in-neuropathic-pain
#9
Flavia Di Pietro, Paul M Macey, Caroline D Rae, Zeynab Alshelh, Vaughan G Macefield, E Russell Vickers, Luke A Henderson
Recurrent thalamocortical connections are integral to the generation of brain rhythms and it is thought that the inhibitory action of the thalamic reticular nucleus is critical in setting these rhythms. Our work and others' has suggested that chronic pain that develops following nerve injury, that is, neuropathic pain, results from altered thalamocortical rhythm, although whether this dysrhythmia is associated with thalamic inhibitory function remains unknown. In this investigation, we used electroencephalography and magnetic resonance spectroscopy to investigate cortical power and thalamic GABAergic concentration in 20 patients with neuropathic pain and 20 pain-free controls...
January 17, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29341303/cardiorespiratory-fitness-is-associated-with-enhanced-hippocampal-functional-connectivity-in-healthy-young-adults
#10
Chelsea M Stillman, Fatma Uyar, Haiqing Huang, George A Grove, Jennifer C Watt, Mariegold E Wollam, Kirk I Erickson
Consistent associations have been found between higher cardiorespiratory fitness (CRF) and indices of enhanced brain health and function, including behavioral measures of cognition as well as neuroimaging indicators such as regional brain volume. Several studies have reported that higher CRF levels are associated with a larger hippocampus, yet associations between volume and memory or functional connectivity metrics with the hippocampus remain poorly understood. Using a multi-modal framework, we hierarchically examine the association between CRF and hippocampal volume and resting state functional connectivity (rsFC) in younger adults (ages 22-38), as well as the relationship between these imaging markers and memory function...
January 17, 2018: Hippocampus
https://www.readbyqxmd.com/read/29338773/chemokine-ligand-receptor-interactions-critically-regulate-cutaneous-wound-healing
#11
Erich Bünemann, Norman-Philipp Hoff, Bettina Alexandra Buhren, Ulrike Wiesner, Stephan Meller, Edwin Bölke, Anja Müller-Homey, Robert Kubitza, Thomas Ruzicka, Albert Zlotnik, Bernhard Homey, Peter Arne Gerber
BACKGROUND: Wound healing represents a dynamic process involving directional migration of different cell types. Chemokines, a family of chemoattractive proteins, have been suggested to be key players in cell-to-cell communication and essential for directed migration of structural cells. Today, the role of the chemokine network in cutaneous wound healing is not fully understood. Unraveling the chemokine-driven communication pathways in this complex process could possibly lead to new therapeutic strategies in wound healing disorders...
January 16, 2018: European Journal of Medical Research
https://www.readbyqxmd.com/read/29337280/behavioral-interventions-for-reducing-head-motion-during-mri-scans-in-children
#12
Deanna J Greene, Jonathan M Koller, Jacqueline M Hampton, Victoria Wesevich, Andrew N Van, Annie L Nguyen, Catherine R Hoyt, Lindsey McIntyre, Eric A Earl, Rachel L Klein, Joshua S Shimony, Steven E Petersen, Bradley L Schlaggar, Damien A Fair, Nico U F Dosenbach
A major limitation to structural and functional MRI (fMRI) scans is their susceptibility to head motion artifacts. Even submillimeter movements can systematically distort functional connectivity, morphometric, and diffusion imaging results. In patient care, sedation is often used to minimize head motion, but it incurs increased costs and risks. In research settings, sedation is typically not an ethical option. Therefore, safe methods that reduce head motion are critical for improving MRI quality, especially in high movement individuals such as children and neuropsychiatric patients...
January 11, 2018: NeuroImage
https://www.readbyqxmd.com/read/29336938/determination-of-the-energy-requirements-in-mechanically-ventilated-critically-ill-elderly-patients-in-different-bmi-groups-using%C3%A2-the-harris-benedict-equation
#13
Pi-Hui Hsu, Chao-Hsien Lee, Li-Kuo Kuo, Yu-Chung Kung, Wei-Ji Chen, Min-Su Tzeng
BACKGROUND: Due to studies on calorie requirement in mechanically ventilated critically ill elderly patients are few, and indirect calorimetry (IC) is not available in every intensive care unit (ICU). The aim of this study was to compare IC and Harris-Benedict (HB) predictive equation in different BMI groups. METHODS: A total of 177 mechanically ventilated critically ill elderly patients (≧65 years old) underwent IC for measured resting energy expenditure (MREE)...
January 11, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/29335352/discrete-modules-and-mesoscale-functional-circuits-for-thermal-nociception-within-primate-s1-cortex
#14
Pai-Feng Yang, Ruiqi Wu, Tung-Lin Wu, Zhaoyue Shi, Li Min Chen
This study addresses one long-standing question of whether functional separations are preserved for somatosensory modalities of touch, heat and cold nociception within primate primary somatosensory (S1) cortex. This information is critical for understanding how the nature of pain is represented in the primate brain. Using a combination of submillimeter-resolution fMRI and microelectrode local field potential (LFP) and spike recordings, we identified spatially-segregated cortical zones for processing touch, nociceptive heat and cold stimuli in somatotopically appropriate areas 3a, 3b, 1, and 2 of S1 in male monkeys...
January 15, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29334328/different-durations-within-the-method-of-best-practice-affect-the-parameters-of-the-speed-duration-relationship
#15
Christoph Triska, Bettina Karsten, Chris Beedie, Bernhard Koller-Zeisler, Alfred Nimmerichter, Harald Tschan
The aim of the study was to determine whether estimates of the speed-duration relationship are affected using different time-trial (TT) field-based testing protocols, where exhaustive times were located within the generally recommended durations of 2-15 min. Ten triathletes (mean ± SD age: 31.0 ± 5.7 years; height: 1.81 ± 0.05 m; body mass: 76.5 ± 6.8 kg) performed two randomly assigned field tests to determine critical speed (CS) and the total distance covered above CS (D´). CS and D´ were obtained using two different protocols comprising three TT that were interspersed by 60 min passive rest...
January 15, 2018: European Journal of Sport Science
https://www.readbyqxmd.com/read/29332419/adolescent-stress-treatment-study-a-cluster-randomized-trial
#16
Stephanie Lynch, Conni DeBlieck, Linda C Summers, Anita Reinhardt, Wanda Borges
High school students experience a variety of stressors. Mental health issues are critical to their health. The "Adolescent Stress Treatment (AST) Study: A Cluster Randomized Trial" compared the efficacy of two stress reduction devices, the EnergyPod™ and the SleepWing™. The EnergyPod™ is a device that provides a semiprivate acoustical and visual environment for rest, stress reduction, and sleep. The SleepWing™ is a smaller device offering similar benefits. High school students were offered the opportunity to participate in the AST study when they exhibited signs of agitation...
January 1, 2018: Clinical Nursing Research
https://www.readbyqxmd.com/read/29331480/human-papillomavirus-hpv-18-genetic-variants-and-cervical-cancer-risk-in-taizhou-area-china
#17
Hui-Hui Xu, Ling-Zhi Zheng, Ai-Fen Lin, Shan-Shan Dong, Ze-Ying Chai, Wei-Hua Yan
Human papillomavirus (HPV) type 18 is predominantly associated with the development of cervical adenocarcinomas, whereas data on HPV18 genetic variability in China are limited. HPV18 genetic variants were formed phylogenetic tree, including lineages A, B, and C. We aimed to evaluate the diversity of HPV18 genetic variants by sequencing the entire E6, E7 and L1 genes. Between 2012 and 2015, a total of 138 (0.8%, 138/17669) women with single HPV18 infection were selected in this study. Finally, we observed 122 HPV18 isolates of the complete E6-E7-L1 sequences, and obtained 36 distinct variation patterns which the accession GenBank numbers as KY457805-KY457840...
January 10, 2018: Gene
https://www.readbyqxmd.com/read/29331263/glial-scars-are-permeable-to-the-neurotoxic-environment-of-chronic-stroke-infarcts
#18
Jacob C Zbesko, Thuy-Vi V Nguyen, Tao Yang, Jennifer Beischel Frye, Omar Hussain, Megan Hayes, Amanda Chung, W Anthony Day, Kristina Stepanovic, Maj Krumberger, Justine Mona, Frank M Longo, Kristian P Doyle
Following stroke, the damaged tissue undergoes liquefactive necrosis, a stage of infarct resolution that lasts for months, although the exact length of time is currently unknown. One method of repair involves reactive astrocytes and microglia forming a glial scar to compartmentalize the area of liquefactive necrosis from the rest of the brain. The formation of the glial scar is a critical component of the healing response to stroke, as well as other central nervous system (CNS) injuries. The goal of this study was to evaluate the toxicity of the extracellular fluid present in areas of liquefactive necrosis and determine how effectively it is segregated from the remainder of the brain...
January 10, 2018: Neurobiology of Disease
https://www.readbyqxmd.com/read/29331064/controlling-the-temporal-structure-of-brain-oscillations-by-focused-attention-meditation
#19
Mona Irrmischer, Simon J Houtman, Huibert D Mansvelder, Michael Tremmel, Ulrich Ott, Klaus Linkenkaer-Hansen
Our focus of attention naturally fluctuates between different sources of information even when we desire to focus on a single object. Focused attention (FA) meditation is associated with greater control over this process, yet the neuronal mechanisms underlying this ability are not entirely understood. Here, we hypothesize that the capacity of attention to transiently focus and swiftly change relates to the critical dynamics emerging when neuronal systems balance at a point of instability between order and disorder...
January 13, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29326151/sex-based-assessment-of-patient-presentation-lesion-characteristics-and-treatment-modalities-in-patients-undergoing-peripheral-vascular-intervention
#20
Niveditta Ramkumar, Bjoern D Suckow, Jeremiah R Brown, Art Sedrakyan, Jack L Cronenwett, Philip P Goodney
BACKGROUND: Limited evidence suggests that women and men might be treated differently for peripheral arterial disease. This analysis evaluated sex-based differences in disease presentation and its effect on treatment modality among patients who underwent endovascular treatment for peripheral arterial disease. METHODS AND RESULTS: Using national registry data from the Vascular Quality Initiative between 2010 and 2013, we examined patient, limb, and artery characteristics by sex through descriptive statistics...
January 2018: Circulation. Cardiovascular Interventions
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