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https://www.readbyqxmd.com/read/28811656/phageterm-a-tool-for-fast-and-accurate-determination-of-phage-termini-and-packaging-mechanism-using-next-generation-sequencing-data
#1
Julian R Garneau, Florence Depardieu, Louis-Charles Fortier, David Bikard, Marc Monot
The worrying rise of antibiotic resistance in pathogenic bacteria is leading to a renewed interest in bacteriophages as a treatment option. Novel sequencing technologies enable description of an increasing number of phage genomes, a critical piece of information to understand their life cycle, phage-host interactions, and evolution. In this work, we demonstrate how it is possible to recover more information from sequencing data than just the phage genome. We developed a theoretical and statistical framework to determine DNA termini and phage packaging mechanisms using NGS data...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28808062/ablating-tbc1d1-impairs-contraction-induced-sarcolemmal-glucose-transporter-type-4-redistribution-but-not-insulin-mediated-responses-in-rats
#2
Jamie Whitfield, Sabina Paglialunga, Brennan K Smith, Paula M Miotto, Genevieve Simnett, Holly L Robson, Swati S Jain, Eric A F Herbst, Eric M Desjardins, David J Dyck, Lawrence L Spriet, Gregory R Steinberg, Graham P Holloway
TBC1 domain family member 1 (TBC1D1), a Rab GTPase-activating protein and paralogue of Akt substrate of 160 kDa (AS160), has been implicated in both insulin- and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (AICAR)-mediated glucose transporter type (GLUT4) translocation. However, the role of TBC1D1 in contracting muscle remains ambiguous. We therefore explored the metabolic consequence of ablating TBC1D1 in both resting and contracting skeletal muscles, utilizing a rat TBC1D1-KO model...
August 14, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28807790/the-functional-domains-for-bax%C3%A2-2-aggregate-mediated-caspase-8-dependent-cell-death
#3
Adriana Mañas, Sheng Wang, Adam Nelson, Jiajun Li, Yu Zhao, Huaiyuan Zhang, Aislinn Davis, Bingqing Xie, Natalia Maltsev, Jialing Xiang
Bax∆2 is a functional pro-apoptotic Bax isoform having alterations in its N-terminus, but sharing the rest of its sequence with Baxα. Bax∆2 is unable to target mitochondria due to the loss of helix α1. Instead, it forms cytosolic aggregates and activates caspase 8. However, the functional domain(s) responsible for BaxΔ2 behavior have remained elusive. Here we show that disruption of helix α1 makes Baxα mimic the behavior of Bax∆2. However, the other alterations in the Bax∆2 N-terminus have no significant impact on aggregation or cell death...
August 11, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28807071/single-rescuer-ventilation-using-a-bag-valve-mask-with-removable-external-handle-a-randomized-crossover-trial
#4
Paul Reed, Baruch Zobrist, Monica Casmaer, Steven G Schauer, Nurani Kester, Michael D April
Introduction Ventilation with a bag valve mask (BVM) is a challenging but critical skill for airway management in the prehospital setting. Hypothesis Tidal volumes received during single rescuer ventilation with a modified BVM with supplemental external handle will be higher than those delivered using a standard BVM among health care volunteers in a manikin model. METHODS: This study was a randomized crossover trial of adult health care providers performing ventilation on a manikin. Investigators randomized participants to perform single rescuer ventilation, first using either a BVM modified by addition of a supplemental external handle or a standard unmodified BVM (Spur II BVM device; Ambu; Ballerup, Denmark)...
August 15, 2017: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/28805502/the-fundamentals-of-cross-sector-collaboration-for-social-change-to-promote-population-health
#5
Joanne G de Montigny, Sylvie Desjardins, Louise Bouchard
Cross-sector collaboration is increasingly relied upon to tackle society's pressing and intractable problems. Chief among societal problems are unfavorable structural and social determinants of health. The ability to positively change these health determinants rests on the collaborative processes and structures of governance across diverse sectors in society. The purpose of this article is to present a conceptual framework that sheds light on the basic requirements of cross-sector collaboration for social change to promote the health of populations...
August 1, 2017: Global Health Promotion
https://www.readbyqxmd.com/read/28804453/delta-power-is-higher-and-more-symmetrical-in-ischemic-stroke-patients-with-cortical-involvement
#6
Chiara Fanciullacci, Federica Bertolucci, Giuseppe Lamola, Alessandro Panarese, Fiorenzo Artoni, Silvestro Micera, Bruno Rossi, Carmelo Chisari
A brain injury resulting from unilateral stroke critically alters brain functionality and the complex balance within the cortical activity. Such modifications may critically depend on lesion location and cortical involvement. Indeed, recent findings pointed out the necessity of applying a stratification based on lesion location when investigating inter-hemispheric balance in stroke. Here, we tested whether cortical involvement could imply differences in band-specific activity and brain symmetry in post stroke patients with cortico-subcortical and subcortical strokes...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28800982/pain-measurement-in-mechanically-ventilated-patients-after-cardiac-surgery-comparison-of-the-behavioral-pain-scale-bps-and-the-critical-care-pain-observation-tool-cpot
#7
Saskia Rijkenberg, Willemke Stilma, Robert J Bosman, Nardo J van der Meer, Peter H J van der Voort
OBJECTIVES: The Behavioral Pain Scale (BPS) and Critical-Care Pain Observation Tool (CPOT) are behavioral pain assessment tools for sedated and unconscious critically ill patients. The aim of this study was to compare the reliability, internal consistency, and discriminant validation of the BPS and the CPOT simultaneously in mechanically ventilated patients after cardiac surgery. DESIGN: A prospective, observational cohort study. SETTING: A 20-bed closed-format intensive care unit with mixed medical, surgical, and cardiac surgery patients in a teaching hospital in Amsterdam, The Netherlands...
August 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/28797999/long-term-results-of-post-operative-pelvic-image-guided-intensity-modulated-radiotherapy-in-gynecological-malignancies
#8
Rashi Agrawal, Sowmiya Prithiviraj, Dinesh Singh, Vaishali Zamre, Sandeep Agrawal, Arun Kumar Goel, Kanika Gupta, Bala Subramanian
OBJECTIVE: To assess late clinical outcomes with image guided intensity modulated radiotherapy (IG- IMRT) in gynecological malignancies. PATIENTS AND METHODS: We have been practicing IG IMRT for gynecological malignancies since January 2009. Here we are presenting our experience with this modern technique at median follow up of 38 months. During whole treatment bladder filling protocol was followed. Both target volumes and critical structures were contoured according to RTOG guidelines...
May 2017: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28797476/temperature-effects-on-aerobic-scope-and-cardiac-performance-of-european-perch-perca-fluviatilis
#9
Denise Lyager Jensen, Johannes Overgaard, Tobias Wang, Hans Gesser, Hans Malte
Several recent studies have highlighted how impaired cardiac performance at high temperatures and in hypoxia may compromise the capacity for oxygen transport. Thus, at high temperatures impaired cardiac capacity is proposed to reduce oxygen transport to a degree that lowers aerobic scope and compromises thermal tolerance (the oxygen- and capacity-limited thermal tolerance (OCLTT) hypothesis). To investigate this hypothesis, we measured aerobic and cardiac performance of a eurythermal freshwater teleost, the European perch (Perca fluviatilis)...
August 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/28795168/changes-in-brain-behavior-relationships-following-a-3-month-pilot-cognitive-intervention-program-for-adults-with-traumatic-brain-injury
#10
S Porter, I J Torres, W Panenka, Z Rajwani, D Fawcett, A Hyder, N Virji-Babul
Facilitating functional recovery following brain injury is a key goal of neurorehabilitation. Direct, objective measures of changes in the brain are critical to understanding how and when meaningful changes occur, however, assessing neuroplasticity using brain based results remains a significant challenge. Little is known about the underlying changes in functional brain networks that correlate with cognitive outcomes in traumatic brain injury (TBI). The purpose of this pilot study was to assess the feasibility of an intensive three month cognitive intervention program in individuals with chronic TBI and to evaluate the effects of this intervention on brain-behavioral relationships...
August 2017: Heliyon
https://www.readbyqxmd.com/read/28790471/should-total-hip-arthroplasty-be-performed-acutely-in-the-treatment-of-acetabular-fractures-in-elderly-or-used-as-a-salvage-procedure-only
#11
Katharine Hamlin, Gabija Lazaraviciute, Michalis Koullouros, Tarak Chouari, Iain M Stevenson, Steven W Hamilton
BACKGROUND: Total hip arthroplasty (THA) is now an increasingly common procedure for people sustaining acetabular fractures. The incidence of acetabular fractures among the elderly population is increasing, and contemporary treatment aims to avoid the risks of prolonged incumbency associated with poor bone stock for fixation or inability to comply with limited weightbearing in this patient group. The concept of acute hip arthroplasty as a treatment for acetabular fracture is, therefore, becoming more topical and relevant...
July 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/28790028/staged-retroperitoneal-mesenteric-revascularisation-and-aortobifemoral-bypass-after-endovascular-rescue-for-acute-mesenteric-ischaemia
#12
Shepard Peir Johnson, Melani Lighter, Harry Linne Anderson, Abdulhameed Aziz
Visceral artery revascularisation through a retroperitoneal approach provides an infrequent yet viable, alternative means of managing mesenteric ischaemia in patients with previous abdominal operations. We present a unique case implementing this surgical approach in a 55-year-old man in which we performed a retroperitoneal aortobifemoral bypass with concomitant retrograde jump graft from the aortic prosthesis to the superior mesenteric artery (SMA) for bilateral lower extremity rest pain and chronic mesenteric ischaemia...
August 8, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28779980/secretion-induces-cell-ph-dynamics-impacting-assembly-disassembly-of-the-fusion-protein-complex-a-combined-fluorescence-and-atomic-force-microscopy-study
#13
REVIEW
Kenneth T Lewis, Akshata R Naik, Suvra S Laha, Sunxi Wang, Guangzhao Mao, Eric Kuhn, Bhanu P Jena
A wide range of cellular activities including protein folding and cell secretion, such as neurotransmission or insulin release, are all governed by intracellular pH homeostasis, underscoring the importance of pH on critical life processes. Nano- scale pH measurements of cells and biomolecules therefore hold great promise in understanding a plethora of cellular functions, in addition to disease detection and therapy. In the current study, a novel approach using cadmium telluride quantum dots (CdTeQDs) as pH sensors, combined with fluorescent imaging, spectrofluorimetry, atomic force microscopy (AFM), and Western blot analysis, enabled the study of intracellular pH dynamics at 1 milli-pH sensitivity and 80nm pixel resolution, during insulin secretion...
August 2, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28777244/the-effect-of-a-sprint-interval-and-resistance-concurrent-exercise-training-program-on-aerobic-capacity-of-inactive-adult-women
#14
Lorena Salom Huffman, Shelby J Foote, Hayden Hyatt, James R McDonald, Danielle D Wadsworth, David D Pascoe
The purpose of this investigation was to examine the effects of high-intensity concurrent exercise training (CET) consisting of sprint intervals (SIT) and resistance exercise (RET) protocols on aerobic capacity in recreationally active, adult females. Fifty-three participants were pair-matched according to preliminary maximal aerobic capacity (VO2max) Bruce protocol assessment into level-grade (SIT0) or 6% incline (SIT6) groups. This 12-week intervention consisted of three CET sessions per week. SIT protocol consisted of 2 (weeks 1-6) then 3 (weeks 7-12) sets of three 40s sprints at specific intensities to evoke responses equivalent to 95% of age-predicted maximal heart rate (HR) interspersed with 20s of rest; with 1-minute of passive recovery between sets...
August 2, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28773861/experimental-study-on-full-scale-beams-made-by-reinforced-alkali-activated-concrete-undergoing-flexure
#15
Linda Monfardini, Fausto Minelli
Alkali Activated Concrete (AAC) is an alternative kind of concrete that uses fly ash as a total replacement of Portland cement. Fly ash combined with alkaline solution and cured at high temperature reacts to form a binder. Four point bending tests on two full scale beams made with AAC are described in this paper. Companion small material specimens were also casted with the aim of properly characterizing this new tailored material. The beam's length was 5000 mm and the cross section was 200 mm × 300 mm. The AAC consisted of fly ash, water, sand 0-4 mm and coarse aggregate 6-10 mm; and the alkaline solution consisted of sodium hydroxide mixed with sodium silicate...
August 30, 2016: Materials
https://www.readbyqxmd.com/read/28768723/lamtor1-is-critically-required-for-cd4-t-cell-proliferation-and-regulatory-t-cell-suppressive-function
#16
Takashi Hosokawa, Tetsuya Kimura, Shigeyuki Nada, Tatsusada Okuno, Daisuke Ito, Sujin Kang, Satoshi Nojima, Kazuya Yamashita, Takeshi Nakatani, Yoshitomo Hayama, Yasuhiro Kato, Yuhei Kinehara, Masayuki Nishide, Norihisa Mikami, Syohei Koyama, Hyota Takamatsu, Daisuke Okuzaki, Naganari Ohkura, Shimon Sakaguchi, Masato Okada, Atsushi Kumanogoh
Mechanistic target of rapamycin complex (mTORC)1 integrates intracellular sufficiency of nutrients and regulates various cellular functions. Previous studies using mice with conditional knockout of mTORC1 component proteins (i.e., mTOR, Raptor, and Rheb) gave conflicting results on the roles of mTORC1 in CD4(+) T cells. Lamtor1 is the protein that is required for amino acid sensing and activation of mTORC1; however, the roles of Lamtor1 in T cells have not been investigated. In this article, we show that Lamtor1-deficient CD4(+) T cells exhibited marked reductions in proliferation, IL-2 production, mTORC1 activity, and expression of purine- and lipid-synthesis genes...
August 2, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28766865/trapping-as-retrieval-technique-to-resolve-a-ruptured-and-entrapped-coronary-balloon-catheter
#17
Javier León Jiménez, Jessica Roa Garrido, Santiago Jesús Camacho Freire, José Francisco Díaz Fernández
A 69 year old male, with a previous percutaneous revascularization of the mid-circumflex with a bare metal stent in 2007 was admitted to our centre for unstable angina. The angiography showed a severely calcified coronary tree with a functionally severe plaque on the proximal left anterior descending artery (LAD) and a critical focal lesion on the proximal right coronary artery. After a high pressure predilation on the proximal LAD, the balloon ruptured causing a retrograde LAD-left main (LM) dissection that was rapidly sealed with three overlapping zotarolimus-eluting stents from medial LAD to LM...
August 2, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28762947/energy-imbalance-alters-ca-2-handling-and-excitability-of-pomc-neurons
#18
Lars Paeger, Andreas Pippow, Simon Hess, Moritz Paehler, Andreas C Klein, Andreas Husch, Christophe Pouzat, Jens C Brüning, Peter Kloppenburg
Satiety-signaling, pro-opiomelanocortin (POMC)-expressing neurons in the arcuate nucleus of the hypothalamus play a pivotal role in the regulation of energy homeostasis. Recent studies reported altered mitochondrial dynamics and decreased mitochondria- endoplasmic reticulum contacts in POMC neurons during diet-induced obesity. Since mitochondria play a crucial role in Ca(2+) signaling, we investigated whether obesity alters Ca(2+) handling of these neurons in mice. In diet-induced obesity, cellular Ca(2+) handling properties including mitochondrial Ca(2+) uptake capacity are impaired, and an increased resting level of free intracellular Ca(2+) is accompanied by a marked decrease in neuronal excitability...
August 1, 2017: ELife
https://www.readbyqxmd.com/read/28761352/use-of-angiotensin-converting-enzyme-inhibitors-and-freedom-from-amputation-after-lower-extremity-revascularization
#19
Jared E Kray, Viktor Y Dombrovskiy, Todd R Vogel
OBJECTIVE: Angiotensin-converting enzyme inhibitors (ACEIs) have not been well evaluated in conjunction with lower extremity revascularization (LER). This study evaluated freedom from amputation in patients who underwent either an open (OPEN) or endovascular (ENDO) revascularization with and without utilization of an ACEI. MATERIALS AND METHODS: Patients who underwent LER were identified from 2007-2008 Medicare Provider Analysis and Review files. Demographics, comorbidities, and disease severity were obtained...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/28756348/measuring-alterations-in-oscillatory-brain-networks-in-schizophrenia-with-resting-state-meg-state-of-the-art-and-methodological-challenges
#20
Golnoush Alamian, Ana-Sofía Hincapié, Annalisa Pascarella, Thomas Thiery, Etienne Combrisson, Anne-Lise Saive, Véronique Martel, Dmitrii Althukov, Frédéric Haesebaert, Karim Jerbi
OBJECTIVE: Neuroimaging studies provide evidence of disturbed resting-state brain networks in Schizophrenia (SZ). However, untangling the neuronal mechanisms that subserve these baseline alterations requires measurement of their electrophysiological underpinnings. This systematic review specifically investigates the contributions of resting-state Magnetoencephalography (MEG) in elucidating abnormal neural organization in SZ patients. METHOD: A systematic literature review of resting-state MEG studies in SZ was conducted...
July 8, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
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