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Schizophrenia games

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https://www.readbyqxmd.com/read/29699895/association-between-increased-serum-d-serine-and-cognitive-gains-induced-by-intensive-cognitive-training-in-schizophrenia
#1
Rogerio Panizzutti, Melissa Fisher, Coleman Garrett, Wai Hong Man, Walter Sena, Caroline Madeira, Sophia Vinogradov
Neuroscience-guided cognitive training induces significant improvement in cognition in schizophrenia subjects, but the biological mechanisms associated with these changes are unknown. In animals, intensive cognitive activity induces increased brain levels of the NMDA-receptor co-agonist d-serine, a molecular system that plays a role in learning-induced neuroplasticity and that may be hypoactive in schizophrenia. Here, we investigated whether training-induced gains in cognition were associated with increases in serum d-serine in outpatients with schizophrenia...
April 23, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29608131/do-patients-with-different-psychiatric-disorders-show-altered-social-decision-making-a-systematic-review-of-ultimatum-game-experiments-in-clinical-populations
#2
Barbara Hinterbuchinger, Alexander Kaltenboeck, Josef Severin Baumgartner, Nilufar Mossaheb, Fabian Friedrich
BACKGROUND: Impairments in social functioning are a common feature of psychiatric disorders. Game paradigms pose a unique way for studying how people make decisions in interpersonal contexts. In the last decade, researchers have started to use these paradigms to study social decision-making in patients with psychiatric disorders. PURPOSE: The aim of this systematic literature review is to summarise the currently available evidence on the behaviour of patients with psychiatric disorders in the commonly used Ultimatum Game (UG)...
April 2, 2018: Cognitive Neuropsychiatry
https://www.readbyqxmd.com/read/29534728/long-non-coding-rna-miat-in-development-and-disease-a-new-player-in-an-old-game
#3
REVIEW
Cheng Sun, Lining Huang, Zhenglong Li, Kaiming Leng, Yi Xu, Xingming Jiang, Yunfu Cui
BACKGROUND: Long non-coding RNAs (lncRNAs), which are a portion of non-protein-coding RNAs (ncRNAs), have manifested a paramount role in the pathophysiology of human diseases, particularly in pathogenesis and progression of disease. Myocardial infarction associated transcript (MIAT), which was recently found to demonstrate aberrant expression in various diseases, such as myocardial infarction, schizophrenia, ischemic stroke, diabetic complications, age-related cataract and cancers, is a novel disease-related lncRNA...
March 13, 2018: Journal of Biomedical Science
https://www.readbyqxmd.com/read/29501256/-computer-assisted-therapy-and-video-games-in-psychosocial-rehabilitation-for-schizophrenia-patients
#4
G Brun, H Verdoux, G Couhet, C Quiles
OBJECTIVES: Video games and virtual reality have recently become used by clinicians for training or information media or as therapeutic tools. The purpose is to review the use of these technologies for therapy destined for schizophrenia patients. METHODS: We conducted a review in October 2016 using Pubmed, Scopus and PsychInfo using the following Medical Subject Headings (MESH): "video games", "virtual reality" and "therapy, computer-assisted/methods", each associated with "schizophrenia"...
February 28, 2018: L'Encéphale
https://www.readbyqxmd.com/read/29379114/comparison-of-focused-cognitive-training-and-portable-brain-games-on-functional-outcomes-for-vocational-rehabilitation-participants
#5
Morris D Bell, Holly Laws, Brian Pittman, Jason K Johannesen
Cognitive remediation performed in a cognitive laboratory was compared with a sham control using portable brain games to study effects on vocational, neurocognitive, and functional outcomes for participants with psychotic disorders in vocational rehabilitation (VR). Seventy-seven participants (61% schizophrenia, 39% other psychosis) in transitional (45.5%) or supported employment (54.5%) were randomly assigned to 6 months of portable cognitive-games (CG) or cognitive remediation (CR) plus a weekly goal-setting group, and evaluated during training, post-training and at 12 months...
January 29, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29352823/neurocognitive-and-self-efficacy-benefits-of-cognitive-remediation-in-schizophrenia-a-randomized-controlled-trial
#6
Shayden D Bryce, Susan L Rossell, Stuart J Lee, Richard J Lawrence, Eric J Tan, Sean P Carruthers, Jennie L Ponsford
OBJECTIVES: The aim of this study was to evaluate the impact of computer-assisted "drill-and-strategy" cognitive remediation (CR) for community-dwelling individuals with schizophrenia on cognition, everyday self-efficacy, and independent living skills. METHODS: Fifty-six people with schizophrenia or schizoaffective disorder were randomized into CR or computer game (CG) playing (control), and offered twenty 1-hr individual sessions in a group setting over 10 weeks...
January 21, 2018: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/29131826/an-interactive-sports-video-game-as-an-intervention-for-rehabilitation-of-community-living-patients-with-schizophrenia-a-controlled-single-blind-crossover-study
#7
Nobuko Shimizu, Tomohiro Umemura, Masahiro Matsunaga, Takayoshi Hirai
Hypofrontality is a state of decreased cerebral blood flow in the prefrontal cortex during executive function performance; it is commonly observed in patients with schizophrenia. Cognitive dysfunction, as well as the psychological symptoms of schizophrenia, influences the ability of patients to reintegrate into society. The current study investigated the effects of an interactive sports video game (IVG; Nintendo Wii™ Sports Resort) on frontal lobe function of patients with schizophrenia. A sample of eight patients (6 male and 2 female; mean age = 46...
2017: PloS One
https://www.readbyqxmd.com/read/29127562/impact-of-a-pilot-videogame-based-physical-activity-program-on-walking-speed-in-adults-with-schizophrenia
#8
H Leutwyler, E Hubbard, B A Cooper, G Dowling
The purpose of this report is to describe the impact of a videogame-based physical activity program using the Kinect for Xbox 360 game system (Microsoft, Redmond, WA) on walking speed in adults with schizophrenia. In this randomized controlled trial, 28 participants played either an active videogame for 30 min (intervention group) or played a sedentary videogame for 30 min (control group), once a week for 6 weeks. Walking speed was measured objectively with the Short Physical Performance Battery at enrollment and at the end of the 6-week program...
November 10, 2017: Community Mental Health Journal
https://www.readbyqxmd.com/read/28924869/the-educational-potential-of-youtube
#9
Haley T Godwin, Murtaza Khan, Peter Yellowlees
OBJECTIVE: The objective of this paper was to examine the educational potential and effectiveness of a 3 min video clip of a simulation of schizophrenia published online at YouTube. METHOD: Researchers examined the 267 public comments published on the video-sharing website YouTube over 8 years by viewers of a schizophrenia simulation video titled "virtual hallucinations" made in the Second Life game platform. Comments were independently categorized into six groupings, then cooperatively finalized, and qualitatively analyzed...
September 18, 2017: Academic Psychiatry
https://www.readbyqxmd.com/read/28895568/response-to-targeted-cognitive-training-correlates-with-change-in-thalamic-volume-in-a-randomized-trial-for-early-schizophrenia
#10
Ian S Ramsay, Susanna Fryer, Alison Boos, Brian J Roach, Melissa Fisher, Rachel Loewy, Sophia Vinogradov, Daniel H Mathalon
Reduced thalamic volume is consistently observed in schizophrenia, and correlates with cognitive impairment. Targeted cognitive training (TCT) of auditory processing in schizophrenia drives improvements in cognition that are believed to result from functional neuroplasticity in prefrontal and auditory cortices. In this study, we sought to determine whether response to TCT is also associated with structural neuroplastic changes in thalamic volume in patients with early schizophrenia (ESZ). Additionally, we examined baseline clinical, cognitive, and neural characteristics predictive of a positive response to TCT...
February 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28878702/stigma-stop-a-serious-game-against-the-stigma-toward-mental-health-in-educational-settings
#11
Adolfo J Cangas, Noelia Navarro, José M A Parra, Juan J Ojeda, Diego Cangas, Jose A Piedra, Jose Gallego
This paper presents the results from the application of a serious game called Stigma-Stop among a group of high school students with the aim of reducing the stigma toward mental illnesses. The video game features characters with various mental disorders (schizophrenia, depression, bipolar disorder, and panic disorder with agoraphobia) and provides information about these problems. Additionally, the game asks players about whether they have ever felt the same as the characters, if they believe the characters are psychologically well, and if they think they could help these individuals...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28845238/trait-aspects-of-auditory-mismatch-negativity-predict-response-to-auditory-training-in-individuals-with-early-illness-schizophrenia
#12
Bruno Biagianti, Brian J Roach, Melissa Fisher, Rachel Loewy, Judith M Ford, Sophia Vinogradov, Daniel H Mathalon
BACKGROUND: Individuals with schizophrenia have heterogeneous impairments of the auditory processing system that likely mediate differences in the cognitive gains induced by auditory training (AT). Mismatch negativity (MMN) is an event-related potential component reflecting auditory echoic memory, and its amplitude reduction in schizophrenia has been linked to cognitive deficits. Therefore, MMN may predict response to AT and identify individuals with schizophrenia who have the most to gain from AT...
2017: Neuropsychiatric Electrophysiology
https://www.readbyqxmd.com/read/28696479/a-web-based-game-for-teaching-facial-expressions-to-schizophrenic-patients
#13
Kemal Hakan Gülkesen, Filiz Isleyen, Buket Cinemre, Mehmet Kemal Samur, Semiha Sen Kaya, Nese Zayim
BACKGROUND: Recognizing facial expressions is an important social skill. In some psychological disorders such as schizophrenia, loss of this skill may complicate the patient's daily life. Prior research has shown that information technology may help to develop facial expression recognition skills through educational software and games. OBJECTIVES: To examine if a computer game designed for teaching facial expressions would improve facial expression recognition skills of patients with schizophrenia...
July 12, 2017: Applied Clinical Informatics
https://www.readbyqxmd.com/read/28662466/informationally-administered-reward-enhances-intrinsic-motivation-in-schizophrenia
#14
Hyeon-Seung Lee, Seon-Kyeong Jang, Ga-Young Lee, Seon-Cheol Park, Alice Medalia, Kee-Hong Choi
Even when individuals with schizophrenia have an intact ability to enjoy rewarding moments, the means to assist them to translate rewarding experiences into goal-directed behaviors is unclear. The present study sought to determine whether informationally administered rewards enhance intrinsic motivation to foster goal-directed behaviors in individuals with schizophrenia (SZ) and healthy controls (HCs). Eighty-four participants (SZ=43, HCs=41) were randomly assigned to conditions involving either a performance-contingent reward with an informationally administered reward or a task-contingent reward with no feedback...
June 17, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28581530/mental-and-behavioural-disorders-in-the-icd-11-concepts-methodologies-and-current-status
#15
REVIEW
Wolfgang Gaebel, Jürgen Zielasek, Geoffrey M Reed
This review provides an overview of the concepts, methods and current status of the development of the Eleventh Revision of the Mental and Behavioural Disorders chapter of the International Classification of Diseases and Related Health Problems (ICD-11) by the World Health Organization (WHO). Given the global use of the current version (ICD-10) for a wide range of applications in clinical practice and health statistics, a major aim of the development process for ICD-11 has been to increase the utility of the classification system...
April 30, 2017: Psychiatria Polska
https://www.readbyqxmd.com/read/28578921/impaired-social-cognition-in-schizophrenia-during-the-ultimatum-game-an-eeg-study
#16
Sibylle K Horat, Grégoire Favre, Anne Prévot, Joseph Ventura, François R Herrmann, Isabelle Gothuey, Marco C G Merlo, Pascal Missonnier
BACKGROUND: Schizophrenia has a core feature of cognitive dysfunctions. Since these deficits are predictive for patients' functional outcome, understanding their origin is of great importance to improve their daily lives. A specific component of the deficit involves social decision-making, which can be studied using the Ultimatum Game (UG). In this task, a "proposer" proposes a share of money to a "responder", who can either accept or reject this offer. If the responder accepts the proposal, both win money...
February 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/28560254/unravelling-socio-motor-biomarkers-in-schizophrenia
#17
Piotr Słowiński, Francesco Alderisio, Chao Zhai, Yuan Shen, Peter Tino, Catherine Bortolon, Delphine Capdevielle, Laura Cohen, Mahdi Khoramshahi, Aude Billard, Robin Salesse, Mathieu Gueugnon, Ludovic Marin, Benoit G Bardy, Mario di Bernardo, Stephane Raffard, Krasimira Tsaneva-Atanasova
We present novel, low-cost and non-invasive potential diagnostic biomarkers of schizophrenia. They are based on the 'mirror-game', a coordination task in which two partners are asked to mimic each other's hand movements. In particular, we use the patient's solo movement, recorded in the absence of a partner, and motion recorded during interaction with an artificial agent, a computer avatar or a humanoid robot. In order to discriminate between the patients and controls, we employ statistical learning techniques, which we apply to nonverbal synchrony and neuromotor features derived from the participants' movement data...
2017: NPJ Schizophrenia
https://www.readbyqxmd.com/read/28476141/theory-of-mind-deficits-partly-mediate-impaired-social-decision-making-in-schizophrenia
#18
Liuqing Yang, Peifu Li, Haiying Mao, Huiling Wang, Chang Shu, Vibeke Bliksted, Yuan Zhou
BACKGROUND: Using paradigms from game theory, researchers have reported abnormal decision-making in social context in patients with schizophrenia. However, less is known about the underpinnings of the impairment. This study aimed to test whether theory of mind (ToM) deficits and/or neurocognitive dysfunctions mediate impaired social decision-making in patients with schizophrenia. METHODS: We compared thirty-five patients with schizophrenia to thirty-eight matched healthy controls with regard to social decision-making using the mini Ultimatum Game (mini UG), a paradigm from game theory...
May 5, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28036406/winner-s-curse-correction-and-variable-thresholding-improve-performance-of-polygenic-risk-modeling-based-on-genome-wide-association-study-summary-level-data
#19
Jianxin Shi, Ju-Hyun Park, Jubao Duan, Sonja T Berndt, Winton Moy, Kai Yu, Lei Song, William Wheeler, Xing Hua, Debra Silverman, Montserrat Garcia-Closas, Chao Agnes Hsiung, Jonine D Figueroa, Victoria K Cortessis, Núria Malats, Margaret R Karagas, Paolo Vineis, I-Shou Chang, Dongxin Lin, Baosen Zhou, Adeline Seow, Keitaro Matsuo, Yun-Chul Hong, Neil E Caporaso, Brian Wolpin, Eric Jacobs, Gloria M Petersen, Alison P Klein, Donghui Li, Harvey Risch, Alan R Sanders, Li Hsu, Robert E Schoen, Hermann Brenner, Rachael Stolzenberg-Solomon, Pablo Gejman, Qing Lan, Nathaniel Rothman, Laufey T Amundadottir, Maria Teresa Landi, Douglas F Levinson, Stephen J Chanock, Nilanjan Chatterjee
Recent heritability analyses have indicated that genome-wide association studies (GWAS) have the potential to improve genetic risk prediction for complex diseases based on polygenic risk score (PRS), a simple modelling technique that can be implemented using summary-level data from the discovery samples. We herein propose modifications to improve the performance of PRS. We introduce threshold-dependent winner's-curse adjustments for marginal association coefficients that are used to weight the single-nucleotide polymorphisms (SNPs) in PRS...
December 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27837574/there-is-no-safe-threshold-for-lead-exposure-%C3%AE-literature-review
#20
REVIEW
Th Vorvolakos, S Arseniou, M Samakouri
Lead was one of the most dangerous environmental toxic substances for a long time in western countries, and this is still the case for many places on earth today. Its neurotoxic potential is highly significant but its secure blood level concentration remains unknown. The aim of this study was to approach the above issue from the perspective of social psychiatry. A systematic search was made of Dialog and Datastar interfaces for data regarding the neuropsychiatric complications of direct or chronic exposure to lead, and a review of the relevant literature was conducted using the databases Medline, Embase, CAB Global Health and Cochrane...
July 2016: Psychiatrikē, Psychiatriki
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