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Fabio Vescini, Giorgio Borretta, Iacopo Chiodini, Marco Boniardi, Marina Carotti, Elena Castellano, Cristiana Cipriani, Cristina Eller-Vainicher, Sandro Giannini, Maurizio Iacobone, Antonio Stefano Salcuni, Federica Saponaro, Stefano Spiezia, Annibale Versari, Guido Zavatta, Zuzana Mitrova, Rosella Saulle, Simona Vecchi, Debora Antonini, Michele Basile, Alexia Giovanazzi, Agostino Paoletta, Enrico Papini, Agnese Persichetti, Irene Samperi, Alessandro Scoppola, Roberto Novizio, Pietro Giorgio Calò, Filomena Cetani, Luisella Cianferotti, Sabrina Corbetta, Maria Luisa De Rimini, Alberto Falchetti, Giovanni Iannetti, Stefano Laureti, Celestino Pio Lombardi, Bruno Madeo, Claudio Marcocci, Sandro Mazzaferro, Vittorio Miele, Salvatore Minisola, Andrea Palermo, Jessica Pepe, Alfredo Scillitani, Laura Tonzar, Franco Grimaldi, Renato Cozzi, Roberto Attanasio
AIM: This guideline (GL) is aimed at providing a clinical practice reference for the management of sporadic primary hyperparathyroidism (PHPT) in adults. PHPT management in pregnancy was not considered. METHODS: This GL has been developed following the methods described in the Manual of the Italian National Guideline System. For each question, the panel appointed by Associazione Medici Endocrinology (AME) and Società Italiana dell'Osteoporosi, del Metabolismo Minerale e delle Malattie dello Scheletro (SIOMMMS) identified potentially relevant outcomes, which were then rated for their impact on therapeutic choices...
December 23, 2023: Endocrine, Metabolic & Immune Disorders Drug Targets
#2
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
April 19, 2024: BMJ Open
#3
JOURNAL ARTICLE
Donal Fitzpatrick, Eamon Laird, Mary Ward, Leane Hoey, Catherine F Hughes, J J Strain, Conal Cunningham, Martin Healy, Anne M Molloy, Helene McNulty, Rosaleen Lannon, Kevin McCarroll
INTRODUCTION: Secondary hyperparathyroidism (SHPT) has adverse implications for bone health but is relatively understudied. In this study we examine the prevalence and determinants of SHPT and describe the relationship of SHPT with bone turnover markers and bone mineral density (BMD) in older Irish adults. METHOD: Eligible participants (n = 4139) were identified from the Trinity-Ulster-Department of Agriculture (TUDA) study, a cohort of Irish adults aged ≥60 years...
April 18, 2024: Bone
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JOURNAL ARTICLE
Meric Coskun, Afruz Babayeva, Tugba Barlas, Mehmet Muhittin Yalcin, Mujde Akturk, Fusun Toruner, Mehmet Ayhan Karakoc, Tarkan Karakan, Mehmet Cindoruk, İlhan Yetkin, Alev Altinova
Parathyroid hormone (PTH) interacts with components of the gut microbiota to exert its bone-regulating effects. This study aimed to investigate the gut microbial composition in patients with primary hyperparathyroidism (PHPT). Nine patients with PHPT and nine age-sex and body mass index-matched healthy controls were included. Gut microbial composition was assessed using 16S rRNA gene amplicon sequencing in both groups at baseline and one month after parathyroidectomy in the PHPT group. Data were imported into QIIME-2 and both QIIME-2 and R packages were used for microbiome analysis...
April 19, 2024: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
#5
JOURNAL ARTICLE
Haleh Chehrehgosha, Hossein Chegini, Iraj Heydari, Hojat Ebrahiminik, Rambod Salouti, Jafar Golzarian
PURPOSE: To present the effectiveness and safety of radiofrequency ablation (RFA) in parathyroid adenoma (PTA). MATERIALS AND METHODS: In this retrospective study, 60 patients with a single PTA were evaluated for changes in biochemical and ultrasonographic features up to 6 months after RFA of the lesion. Adenomas were ablated with an alternative technique so called "Nik jet dissection" which incorporates full hydrodissection and polar artery coagulation. Complications as well as the variations in biochemical data and nodule volumes were analyzed between baseline measurements and at each follow-up interval data (first day, 1, 3, and 6 months after ablation) were analyzed...
April 19, 2024: Cardiovascular and Interventional Radiology
#6
Kimitaka Shibue, Nozomi Kubo, Hiromi Oda, Etsuko Tanabe, Tsutomu Okada, Cheng-Long Huang, Toshihiro Higuchi, Akihiro Hamasaki, Nobuya Inagaki
In the realm of obstetric care, discerning the subtle signs of primary hyperparathyroidism (PHPT) amidst common pregnancy symptoms remains a formidable challenge. Our exploration into a case of gestational hypercalcemia peels back the layers of this complexity, revealing the clinical conundrum posed by overlapping gastrointestinal manifestations. The journey from diagnosis through surgical intervention to the resolution of symptoms underscores the importance of vigilance for PHPT in pregnant patients. This case further prompts consideration of gamma-aminobutyric acid (GABA) as a potential piece in the puzzle of persistent symptoms post-calcium normalization, inviting a broader dialogue on the intricacies of parathyroid pathology in pregnancy...
March 2024: Curēus
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Martina Cicia, Giampaolo Papi, Alfredo Scillitani, Stefania Corrado, Pietro Locantore, Alfredo Pontecorvi
Parathyroid carcinoma (PC) is a rare endocrine neoplasm that typically presents with osteopenia/osteoporosis, nephrolithiasis, asthenia, and neuropsychiatric symptoms. We describe the case of a 48-year-old woman, presenting with a large painful hematoma in the cervicomediastinal area. The neck ultrasound (US) demonstrated a solid lesion measuring 40 × 80 × 55 mm, markedly hypoechoic, which extended from the right thyroid lobe to the mediastinum. The blood tests showed elevated serum calcium and parathyroid hormone (PTH) concentrations, consistent with hypercalcemic primary hyperparathyroidism...
April 2024: JCEM Case Rep
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JOURNAL ARTICLE
Donovan Tay, John P Bilezikian
Although PTH is best known for its role as a regulator of skeletal remodelling and calcium homeostasis, more recent evidence supports a role for it in energy metabolism and other non-classical targets. In this report, we summarize evidence for an effect of PTH on adipocytes. This review is based upon all peer-reviewed papers, published in the English language with PubMed as the primary search engine. Recent preclinical studies have documented an effect of PTH to stimulate lipolysis in both adipocytes and liver cells and to cause browning of adipocytes...
April 18, 2024: Journal of Bone and Mineral Research
#9
REVIEW
F Cetani, E Dinoi, L Pierotti, E Pardi
BACKGROUND: Familial primary hyperparathyroidism (PHPT) includes syndromic and non-syndromic disorders. The former are characterized by the occurrence of PHPT in association with extra-parathyroid manifestations and includes multiple endocrine neoplasia (MEN) types 1, 2, and 4 syndromes, and hyperparathyroidism-jaw tumor (HPT-JT). The latter consists of familial hypocalciuric hypercalcemia (FHH) types 1, 2 and 3, neonatal severe primary hyperparathyroidism (NSHPT), and familial isolated primary hyperparathyroidism (FIHP)...
April 18, 2024: Journal of Endocrinological Investigation
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JOURNAL ARTICLE
Hiroyuki Yamashita, Shinya Sato, Hisakazu Shindo, Yusuke Mori, Kouichi Yoshimoto, Seigo Tachibana, Takashi Fukuda, Hiroshi Takahashi
PURPOSE: To investigate the parathyroid function and calcium (Ca) levels in the secondary hyperparathyroidism (SHPT) state in patients with Graves' disease. METHODS: We examined 31 consecutive patients with Graves' disease without chronic kidney disease, who were treated with total thyroidectomy. The patients were divided into a normal parathyroid hormone (PTH) group (NPTH group; n = 19) with a PTH level ≤ 65 pg/mL, and a secondary hyperparathyroidism group (SHPT group; n = 12), with a PTH level > 65 pg/mL...
April 18, 2024: Surgery Today
#11
JOURNAL ARTICLE
Gianmarco Lombardi, Pietro Manuel Ferraro, Elisa De Tomi, Matteo Bargagli, Andrea Spasiano, Giovanni Gambaro
BACKGROUND AND HYPOTHESIS: Chronic kidney disease (CKD) is a growing global health concern. Recent research has indicated sex disparities in CKD-related complications, yet the impact of sex differences on critical kidney function levels that trigger these complications and mortality remains inadequately documented. METHODS: We investigated sex-specific disparities in CKD-related complications and mortality according to eGFR levels. We analyzed NHANES data spanning from 1999 to 2018, including adult participants with an eGFR of 15-150 ml/min per 1...
April 17, 2024: Nephrology, Dialysis, Transplantation
#12
Chukwunonso Ezeani, Gift Echefu, Ifeoluwa Stowe, Damodar Kumbala, Shatha Murad
Parathyroid carcinoma is a rare malignancy; and it is rarer to find one located in an ectopic location. Ectopic parathyroid glands are a reported cause of failed primary surgery for hyperparathyroidism. We report here a 73-year-old male who previously had parathyroidectomy for primary hyperparathyroidism but then had recurrence of his symptoms with a diagnosis of a mediastinal parathyroid carcinoma on further evaluation. This presentation of complicated mediastinal parathyroid carcinoma posed significant diagnostic and management challenges due to comorbid stage IV chronic kidney disease (CKD)...
2024: SAGE Open Medical Case Reports
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JOURNAL ARTICLE
Kai Fu, Xin-Yu Zhu, Xin-Yu Jia, Kun-Peng Feng, Yuan Cui, Jun Zhao, Chang Li
BACKGROUND: The ectopic superior parathyroid in the tracheoesophageal groove and paraesophageal region is rare. Hyperparathyroidism results when these glands become hyperfunctioning. That may necessitate surgical intervention in the form of parathyroidectomy, which requires a transsternal or transthoracic approach due to a deeply seated mediastinal parathyroid gland. Minimally invasive strategies have emerged recently as an alternative approach with less morbidity. CASE PRESENTATION: We present a case of the paraesophageal ectopic parathyroid gland in the superior posterior mediastinum, which was successfully treated with thoracoscopic resection...
April 16, 2024: Journal of Cardiothoracic Surgery
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JOURNAL ARTICLE
Wenwen Yue, Tingting Jiang, Zisheng Ai, Erya Deng, Huihui Chai, Xiaolong Li, Hongfeng He, Zhengxian Zhang, Ning Weng, Xiachuan Qin, Jing Fan, Xiaoqing Tang, Wei Heng, Yong Li, Liping Sun, Chengzhong Peng, Huixiong Xu
Background Although favorable outcomes have been reported with radiofrequency ablation (RFA) for secondary hyperparathyroidism (SHPT), the long-term efficacy remains insufficiently investigated. Purpose To evaluate the long-term efficacy and safety of US-guided percutaneous RFA in patients with SHPT undergoing dialysis and to identify possible predictors associated with treatment failure. Materials and Methods This retrospective study included consecutive patients with SHPT with at least one enlarged parathyroid gland accessible for RFA who were undergoing dialysis at seven tertiary centers from May 2013 to July 2022...
April 2024: Radiology
#15
Mansi Satasia, Archit Garg, Kulani Weerasinghe, Chirag Patel, Mario Caldararo
Sarcoidosis is a systemic inflammatory condition characterized by noncaseating granulomas. Lung involvement is typical, while extrapulmonary manifestations, notably lymphadenopathy, are observed in a significant proportion of cases. The etiology involves complex interactions among immune cells and mediators, resulting in granuloma formation capable of independently producing 1,25-dihydroxyvitamin D, leading to unregulated hypercalcemia and hypercalciuria. Diagnosis can be challenging, especially when hypercalcemia is the initial symptom...
March 2024: Curēus
#16
JOURNAL ARTICLE
Mehmet Zafer Sabuncuoglu, Isa Sozen, İsmail Zihni, Girayhan Celik, Nesime Inci Eryılmaz, Fatma Nur Dal, Demet Gunduz, Ozer Makay
BACKGROUND Primary hyperparathyroidism is one of the most common endocrine disorders, for which the definitive treatment is surgical parathyroidectomy. Generally, surgical exploration is performed as open focused neck surgery. The vestibular route is a new approach to minimally invasive endoscopic parathyroidectomy. This retrospective study from a single center in Turkey aimed to compare surgical outcomes from the transoral endoscopic vestibular approach (TOEPVA) vs direct open parathyroidectomy in 57 patients...
April 16, 2024: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
#17
JOURNAL ARTICLE
Paolo Del Rio, Marco Boniardi, Loredana De Pasquale, Giovanni Docimo, Maurizio Iacobone, Gabriele Materazzi, Fabio Medas, Michele Minuto, Barbara Mullineris, Andrea Polistena, Marco Raffaelli, Pietro Giorgio Calò
A task force of the United Italian society of Endocrine Surgery (SIUEC) was commissioned to review the position statement on diagnostic, therapeutic and health‑care management protocol in parathyroid surgery published in 2014, at the light of new technologies, recent oncological concepts, and tailored approaches. The objective of this publication was to support surgeons with modern rational protocols of treatment that can be shared by health-care professionals, taking into account important clinical, healthcare and therapeutic aspects, as well as potential sequelae and complications...
April 15, 2024: Updates in Surgery
#18
JOURNAL ARTICLE
S Abouzian, D A López-Mora, A Fernández-León, C Facundo, P Stefaneli, A Flotats
No abstract text is available yet for this article.
April 13, 2024: Revista española de medicina nuclear e imagen molecular
#19
Asmara Hussain, Fatima Shahid, Nur Ul Ain
In this case study, we present an incidentally discovered giant cell granuloma, which, upon detailed investigation, led to an unexpected diagnosis. A 36-year-old woman exhibited a bone lesion in the right retromolar trigone area, initially suspected of being malignant. However, histopathological examination revealed a giant cell tumor of bone. Further biochemical profiling, including serum calcium, phosphorus, and parathyroid hormone (PTH) levels, showed elevated PTH and hypercalcemia, prompting consideration of primary hyperparathyroidism and the diagnosis of a brown tumor due to this condition...
March 2024: Curēus
#20
Styliani Laskou, Ismini Kountouri, Eleni Paschou, Christos Topalidis, Paraskevi Axi, Georgios Petrakis, Christoforos Kosmidis, Konstantinos Sapalidis
Atypical parathyroid tumors represent a group of parathyroid neoplasms of uncertain malignant potential. In view of preoperative diagnostic difficulties, suspicious features for malignancy may guide the surgeon to perform a radical surgical approach.
April 2024: Clinical Case Reports
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