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Cheng Fang, Eleni Konstantatou, Nicola J Mulholland, Serena Baroncini, Mohammad A Husainy, Klaus-Martin Schulte, Paul S Sidhu
Purpose: To identify the variant features encountered in parathyroid abnormalities and document those suggesting malignant change. Materials and methods: Data were collected from a cohort of patients who underwent investigation for primary hyperparathyroidism over a 10-year period. Ultrasonographic features: shape, presence of calcification, cystic changes, heterogeneous echogenicity, vascularity, capsular thickening, local invasion, and vascularity were reviewed retrospectively and were used to correlate with final histological findings...
May 2018: Ultrasound: Journal of the British Medical Ultrasound Society
Alexandria D McDow, Rebecca S Sippel
Asymptomatic primary hyperparathyroidism is a very common endocrine condition, yet management of this disease process remains controversial. Primary hyperparathyroidism can lead to a myriad of symptoms which not only decreases the quality of life of patients but also increases the risk of cardiovascular disease, osteoporosis, and kidney stones. Parathyroidectomy is the only known cure for the disease. This review explores the definition of asymptomatic primary hyperparathyroidism, the burden of disease, and the overwhelming benefits of parathyroidectomy...
2018: Clinical Medicine Insights. Endocrinology and Diabetes
Fatemeh Khatami, Seyed Mohammad Tavangar
Multiple endocrine neoplasia (MEN) syndromes are infrequent inherited disorders in which more than one endocrine glands develop noncancerous (benign) or cancerous (malignant) tumors or grow excessively without forming tumors. There are 3 famous and well-known forms of MEN syndromes (MEN 1, MEN 2A, and MEN 2B) and a newly documented one (MEN4). These syndromes are infrequent and occurred in all ages and both men and women. Usually, germ line mutations that can be resulted in neoplastic transformation of anterior pituitary, parathyroid glands, and pancreatic islets in addition to gastrointestinal tract can be an indicator for MEN1...
2018: Biomarker Insights
Jena Patel, Mary Barna Bridgeman
Etelcalcetide (Parsabiv) for hyperparathyroidism in adults with chronic kidney disease on hemodialysis.
July 2018: P & T: a Peer-reviewed Journal for Formulary Management
Kristin Godang, Karolina Lundstam, Charlotte Mollerup, Stine Lyngvi Fougner, Ylva Pernow, Jörgen Nordenström, Thord Rosen, Svante Jansson, Mikael Hellström, Jens Bollerslev, Ansgar Heck
CONTEXT: Mild primary hyperparathyroidism has been associated with increased body fat mass and unfavorable cardiovascular risk factors. OBJECTIVE: To assess the effect of parathyroidectomy on fat mass, glucose and lipid metabolism. Design, Patients, Interventions, Main outcome measures: 119 patients previously randomized to observation (OBS; n=58) or parathyroidectomy (PTX; n=61) within the Scandinavian Investigation of Primary Hyperparathyroidism (SIPH) trial, an open randomized multicenter study, were included...
July 16, 2018: Endocrine Connections
I Bombil, L Louw, C Mitchell, F Mahlobo, R A Muganza, N R Madima
BACKGROUND: Presentation of hyperparathyroidism varies and is highly non-specific. The automated calcium analyzer has made the diagnosis easy. Similarly, the advent of Sestamibi scan has paved the way to minimally invasive parathyroidectomy indicated for parathyroid adenoma. There is no uniformity in the extent of minimally invasive parathyroidectomy that is done through limited incision under radio or sonar guidance and endoscopically. In this study, we are presenting the focused parathyroidectomy performed under sonar guidance and superficial cervical block (SCB)...
June 2018: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
Keith E Eidman, James B Wetmore
Secondary hyperparathyroidism (SHPT), commonly encountered in patients receiving maintenance dialysis, is associated with numerous adverse outcomes, including mortality. Calcimimetics, agents that act on the calcium sensing receptor (CaSR), were designed to overcome limitations in the use of vitamin D sterols to treat SHPT, and have demonstrated efficacy in reducing levels of PTH in randomized trials. Currently available calcimimetics include oral cinacalcet and the recently approved intravenously administered agent, etelcalcetide...
July 15, 2018: Seminars in Dialysis
Asena Gökçay Canpolat, Mustafa Şahin, Elif Ediboğlu, Murat Faik Erdoğan, Sevim Güllü, Özgür Demir, Rıfat Emral, Demet Çorapçioğlu
INTRODUCTION: Minimally invasive surgery is an alternative surgical approach for primary hyperparathyroidism with less surgical trauma and anesthesia complications. When combined with intraoperative measurement of parathyroid hormone (PTH), cure rates are exceeding 97%. Preoperative intact PTH determination in washout samples is really very useful when parathyroid lesions can not be easily distinguished from thyroid lesions or sometimes lymph nodes. Herein, we aimed to report our institutional experience about parathyroid fine needle aspiration (FNA) method and suggest a cut-off ratio for this purpose...
July 13, 2018: Clinical Endocrinology
Virgilijus Beiša, Neringa Pranskevičiūtė, Gabija Makūnaitė, Kęstutis Strupas
Primary hyperparathyroidism is overproduction of parathyroid hormone, causing hypercalcemia. Parathyroid adenomas have been found to be the etiology for 80% of cases of primary hyperparathyroidism, while almost a quarter of them are ectopic. We present a case of ectopic thymic parathyroid adenoma, treated by the thoracoscopic approach. Preoperative computed tomogram and technetium-99-sestamibi imaging showed an adenoma, located in the front mid-mediastinum, approximately 8 × 10 mm in size. Resection of the tumor was indicated according to the persistent hypercalcemia after unsuccessful surgical treatment performed 3 years ago...
June 2018: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
Sara Shakeri, Soroush Zarehparvar Moghadam, Ramin Sadeghi, Narjess Ayati
Sagliker syndrome is a rare form of renal osteodystrophy resulted from untreated secondary hyperparathyroidism. It is described by severe skeletal deformities, high level of PTH in patients with chronic renal failure, and deformed face. This paper reports a 44-year-old male patient with the mentioned characteristics. In addition to the unique clinical features, high levels of ALP and PTH hormones encouraged us to search for syndrome-like a disease, which clinically and paraclinically matched the Sagliker syndrome...
2018: Asia Oceania Journal of Nuclear Medicine & Biology
Owen Alvine, Gregory Alvine
We present a case of osteitis fibrosa cystica (OFC), also known as "brown tumor." A 55-year old female was admitted to the hospital with several months of right hip pain that was becoming more severe. A malignant lesion of the pelvis was suspected after initial imaging studies. Significant hypercalcemia led to a diagnosis of hyperparathyroidism and ultimately a benign parathyroid adenoma. Surgical excision of the adenoma resulted in full resolution of the tumor in her pelvis as well as her pain. It is important to keep OFC, or brown tumor, in your differential diagnoses when presented with a bone lesion...
April 2018: South Dakota Medicine: the Journal of the South Dakota State Medical Association
Theodosios S Papavramidis, Angeliki Chorti, Ioannis Pliakos, Stavros Panidis, Antonios Michalopoulos
BACKGROUND: Parathyroid cysts are lesions that represent 1-5% of neck masses. They are subdivided into two categories: functioning and non-functioning.The aim of the present review is to give a detailed account of all reported cases of parathyroid cysts in the literature and to analyze statistically the available data. METHODS: A bibliographic research was performed from 1905 until 2016. A database with the patients' characteristics was made and analyzed statistically...
July 2018: Medicine (Baltimore)
Can Pang, Youben Fan, Huizheng Zhang, Haoyong Yu, Bomin Guo, Jie Kang, Xianzhao Deng, Yuqian Bao
RATIONALE: Parathyroid hormone PTH) levels are the main parameters to differentiate primary hyperparathyroidism (PHPT) from non-PTH-dependent hypercalcemia. We report a case of hypercalcemia with normal PTH levels due to a parathyroid adenoma. PATIENT CONCERNS: A 52-year-old female patient presented with 2-year history of documented sustained high-normal serum calcium and hypercalcemia (2.51-3.03 mmol/L) with normal serum intact PTH levels (21.95-40.15 pg/ mL)...
July 2018: Medicine (Baltimore)
Irene Ruderman, Stephen G Holt, Geoffrey S Kirkland, Sophie Maslen, Carmel M Hawley, Veronica Oliver, Rathika Krishnasamy, Nicholas A Gray, Girish S Talaulikar, Craig L Nelson, Yogeshwar Rajaram, Hilton Gock, Eric Au, Grahame J Elder, Rahul Mainra, Nigel D Toussaint
BACKGROUND: Secondary hyperparathyroidism (SHPT) in chronic kidney disease is associated with cardiovascular and bone pathology. Measures to achieve parathyroid hormone (PTH) target values and control biochemical abnormalities associated with SHPT require complex therapies, and severe SHPT often requires parathyroidectomy or the calcimimetic cinacalcet. In Australia, cinacalcet was publicly funded for dialysis patients from 2009 to 2015 when funding was withdrawn following publication of the EVOLVE study, which resulted in most patients on cinacalcet ceasing therapy...
July 10, 2018: Internal Medicine Journal
Xiuzhen Zhang, Fengyi Yuan
Primary hyperparathyroidism (PHPT) in pregnancy presents a threat to the health of both mother and fetus [1]. The prevalence is reported to be between 0.15 and 1.4%[2], which may be underestimated due largely to the atypical symptoms of PHPT during pregnancy. A 39-year-old woman at 17th week of pregnancy was sent to our emergency department with a history of 72 hours of nausea and repeated vomiting. This article is protected by copyright. All rights reserved.
July 10, 2018: Clinical Endocrinology
Sidharth Kumar Sethi, Shyam Bihari Bansal, Nikita Wadhwani, Mayur Makasana, Ashish Nandwani, Vijay Kher, Rupesh Raina
No abstract text is available yet for this article.
July 2018: KI Reports
Muhammad Usman Janjua, Xiao-Dan Long, Zhao-Hui Mo, Chang-Sheng Dong, Ping Jin
BACKGROUND: Medullary sponge kidney is a rare renal malformation, which usually manifests as nephrocalcinosis, renal tubular acidosis, and recurrent urinary tract infections. Medullary sponge kidney is often associated with renal developmental anomalies and tumors, and its exact pathogenesis is not yet clearly explained. Given the key role of the interaction of glial cell line-derived neurotrophic factor gene, GDNF, and the "rearranged during transfection" proto-oncogene, RET, in kidney and urinary tract development, variations in these genes are proposed to be candidates for medullary sponge kidney...
July 9, 2018: Journal of Medical Case Reports
Qian Zhang, Shensen Li, Guoxin Ye, Mengjing Wang, Li Ni, Sen Kan, Minmin Zhang, Jing Chen
Background: Secondary hyperparathyroidism (SHPT) in patients with end-stage renal disease (ESRD) is characterized by hyperplasia of the parathyroid glands (PTGs), while the underlying mechanism is not completely understood. Previously we demonstrated a relationship between cyclooxygenase 2 (COX2) overexpression and parathyroid hyperplasia and here we investigate the role of COX2 downstream metabolic product prostaglandin E2 (PGE2) and its receptor EP2 in the pathogenesis of SHPT. Methods: PTGs isolated from ESRD patients with advanced SHPT were used to test the expression of COX2-microsomal prostaglandin E synthase-1 (mPGES-1)-EP2 pathway...
July 5, 2018: Nephrology, Dialysis, Transplantation
Sharon M Moe, Jin Long, Tae-Hwi Linus Schwantes-An, Brian S Decker, Leah Wetherill, Howard J Edenberg, Xiaoling Xuei, Matteo Vatta, Tatiana M Foroud, Glenn M Chertow
Background: Cardiovascular mortality in patients receiving dialysis remains unacceptably high, with unexplained ancestry differences suggesting a genetic component. Methods: We analyzed DNA samples from 37% of subjects enrolled in the EValuation Of Cinacalcet Hydrochloride (HCl) Therapy to Lower CardioVascular Events (EVOLVE) trial, a randomized trial conducted in patients receiving hemodialysis with secondary hyperparathyroidism, comparing cinacalcet to placebo on a background of usual care...
July 2, 2018: Nephrology, Dialysis, Transplantation
Zhe Wei, Bin Sun, Zong-Ping Wang, Jin-Wei He, Wen-Zhen Fu, You-Ben Fan, Zhen-Lin Zhang
Primary hyperparathyroidism is commonly casused by excess production of parathyroid hormone from sporadic parathyroid adenomas. However, the genetic architecture of sporadic primary hyperparathyroidism remains largely uncharacterized, especially in the Chinese population. To identify novel genetic abnormalities that may be involved in the etiology of sporadic parathyroid adenomas and to determine the mutation frequency of previously identified genes in the Chinese population, we performed whole-exome sequencing of 22 blood-tumor pairs from sporadic parathyroid adenomas...
July 3, 2018: Endocrinology
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