keyword
MENU ▼
Read by QxMD icon Read
search

hyperglicemia

keyword
https://www.readbyqxmd.com/read/27354525/epigenetics-and-energetics-in-ventral-hippocampus-mediate-rapid-antidepressant-action-implications-for-treatment-resistance
#1
Benedetta Bigio, Aleksander A Mathé, Vasco C Sousa, Danielle Zelli, Per Svenningsson, Bruce S McEwen, Carla Nasca
Although regulation of energy metabolism has been linked with multiple disorders, its role in depression and responsiveness to antidepressants is less known. We found that an epigenetic and energetic agent, acetyl-l-carnitine (LAC, oral administration), rapidly rescued the depressive- and central and systemic metabolic-like phenotype of LAC-deficient Flinders Sensitive Line rats (FSL). After acute stress during LAC treatment, a subset of FSL continued to respond to LAC (rFSL), whereas the other subset did not (nrFSL)...
July 12, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27097010/diabetic-hemichorea-hemiballismus-with-nonketotic-hyperglicemia-a-rare-cause-of-hyperkinetic-movement-disorders
#2
Lucas Giansante Abud, Thiago Giansante Abud, Rodolfo Mendes Queiroz, Giovanni Salton Pietroni, Daniel Giansante Abud
No abstract text is available yet for this article.
April 2016: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/26343077/age-abdominal-obesity-and-glycated-hemoglobin-are-associated-with-carotid-atherosclerosis-in-type-2-diabetes-patients-with-nonalcoholic-fatty-liver-disease
#3
Cristina Alina Silaghi, Horațiu Silaghi, Anca Elena Crăciun, Anca Fărcaș, Horațiu Alexandru Colosi, Daniel Tudor Cosma, Raluca Pais, Nicolae Hâncu, Carmen Emanuela Georgescu
AIM: The aim of this study was to evaluate the impact of clinical parameters and indices of body composition on the relation between non-alcoholic fatty liver disease (NAFLD) and carotid intima-media thickness (cIMT), in a type 2 diabetes mellitus population (T2DM). MATERIAL AND METHODS: We retrospectively enrolled 336 T2DM outpatients who regularly attended Regina Maria Clinic in Cluj. Clinical, anthropometric and biochemical parameters were measured. Ultrasonography (US) was used to assess hepatic steatosis (HS) in all patients and cIMT in 146 subjects...
September 2015: Medical Ultrasonography
https://www.readbyqxmd.com/read/24794552/protein-kinase-c-in-enhanced-vascular-tone-in-diabetes-mellitus
#4
REVIEW
Igor V Kizub, Kateryna I Klymenko, Anatoly I Soloviev
Diabetes mellitus (DM) is a complex syndrome which leads to multiple dysfunctions including vascular disorders. Hyperglycemia is considered to be a key factor responsible for the development of diabetic vascular complications and can mediate their adverse effects through multiple pathways. One of those mechanisms is the activation of protein kinase C (PKC). This important regulatory enzyme is involved in a signal transduction of several vascular functions including vascular smooth muscle contractility. Many studies have shown that hyperglycemia in DM results in oxidative stress...
June 15, 2014: International Journal of Cardiology
https://www.readbyqxmd.com/read/24640089/-features-of-early-stages-of-cardiovascular-continuum-in-workers-engaged-in-oil-extracting-enterprise
#5
A E Nosov, A S Baĭdina, O Iu Ustinova
The authors present data on metabolic disorders and vascular state in workers of oil extracting enterprise, exposed to complex of occupational hazards (noise, work hardiness, chemical factors). Major role among chemical hazards is played by aromatic hydrocarbons. In clinical and epidemiologic studies, arterial hypertension was reliably more frequent in a group of oil extraction workers. Findings are that oil extraction workers, when compared to the reference group, demonstrate more marked metabolic disorders (dyslipidemia with increased total cholesterol and low density lipoproteins, hyperuricemia, hyperglicemia, increased lipids peroxidation) with endothelial dysfunction...
2013: Meditsina Truda i Promyshlennaia Ekologiia
https://www.readbyqxmd.com/read/23724531/comparison-of-hba1c-levels-in-obese-and-non-obese-polycystic-ovarian-patients
#6
COMPARATIVE STUDY
A N Unluer, R B Findik, N Sevinc, J Karakaya
AIM: To compare obese and non-obese polycystic ovary syndrome (PCOS) patients with respect to lipid profile, hormone profiles, and hemoglobin A1c (HbA1c) values indicating chronic hyperglicemia. MATERIALS AND METHODS: Thirty PCOS patients with a body mass index (BMI) > 25 and 35 non-obese PCOS patients with BMI < 25 were compared with regard to basal luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin (PRL), estradiol (E2), fasting blood sugar (FBS), low-density lipoprotein (LDL), high-density lipoprotein (HDL), total cholesterol (TCOL), triglyceride (TG), and HbA1c values...
2013: Clinical and Experimental Obstetrics & Gynecology
https://www.readbyqxmd.com/read/23073120/is-prediabetes-risk-factor-for-hair-loss
#7
Evrim Cakir
In the recent hypothesis that hair loss might be a manifestation of metabolic abnormalities particularly hyperglicemia. It has been reported various environmental risk factors affecting hair loss. There is growing evidence on the relationship between prediabetes and worse metabolic profile. However, there are few studies about the association between hair loss, metabolic disorder and diabetes. Therefore patients that admitted the hospital with hair loss should be screened for diabetes mellitus and prediabetes...
December 2012: Medical Hypotheses
https://www.readbyqxmd.com/read/21427883/-ultrasonography-measurement-of-intrabdominal-visceral-fat-in-obese-men-association-with-alterations-in-serum-lipids-and-insulinemia
#8
Edgar Navarro, Volga Mijac, Hermes Flórez y Elena Ryder
Abdominal obesity and specifically intrabdominal adiposity leads to increase in cardiometabolic risk factors (CMR), independently of body mass index (BMI). In order to examine CMR factors associated with the presence of visceral fat (VF) in individuals with different degrees of overweight/obesity, 154 men, 20 to 60 years of age, attending a at an Industrial Clinic in Venezuela, were evaluated. Ultrasound was used to establish the presence and amount of VF. As expected, VF values were higher as the BMI increased...
June 2010: Archivos Latinoamericanos de Nutrición
https://www.readbyqxmd.com/read/20716919/camp-activates-the-generation-of-reactive-oxygen-species-and-inhibits-the-secretion-of-il-6-in-peripheral-blood-mononuclear-cells-from-type-2-diabetic-patients
#9
Camila Armond Isoni, Erica Abreu Borges, Clara Araújo Veloso, Rafael Teixeira Mattos, Miriam Martins Chaves, José Augusto Nogueira-Machado
Peripheral blood mononuclear cells (PBMNC) from patients with type 2 diabetes (DM2) have generated higher levels of reactive oxygen species (ROS) that were higher than those in cells from healthy individuals. In the presence of a cAMP-elevating agent, ROS production was significantly activated in PBMNC from DM2 patients but it was inhibited in cells from healthy subjects. Higher levels of IL-6 has been detected in the supernatant of PBMNC cultures from DM2 patients in comparison with healthy controls. When cells were cultured in the presence of a cAMP-elevating agent, the level of IL-6 decreased has by 46% in the supernatant of PBMNC from DM2 patients but it remained unaltered in controls...
November 2009: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/20687985/-association-of-gamma-glutamyltransferase-metabolic-syndrome-and-cardiovascular-risk
#10
Maria Carmo Martins, Luís Lima Faleiro, Beatriz Afonso, Aidil Fonseca
Serum gamma-glutamyl transferase (GGT) has been used as a marker of alcohol induced liver disease. Recent epidemiology and pathology studies have suggested its independent role in the pathogenesis and clinical evolution of cardiovascular diseases (CVD) promoting atherosclerosis through an oxidative process leading, within the atherosclerotic plaque, to LDL oxidation, metalloproteinase activation, cell proliferation and apoptosis. Besides it is known that GGT levels rise even in the normal range, with obesity and hepatic steatosis occurs, it is thought, which originates insulin resistance (IR)...
July 2010: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/20465157/influence-of-admission-plasma-glucose-level-on-short-and-long-term-prognosis-in-patients-with-st-segment-elevation-myocardial-infarction
#11
Violeta Mladenović, Vladimir Zdravković, Marina Jović, Rada Vucić, Violeta Irić-Cupić, Mirko Rosić
BACKGROUND/AIM: Hyperglicemia is common in patients with ST-elevation myocardial infarction (STEMI) and is associated with high risk of mortality and morbidity. Relationship between admission plasma glucose (APG) levels and mortality in diabetic and nondiabetic patients with STEMI needs further investigation. The aim of this study was to analyse the short- and long-term prognostic significance of APG levels in patients with STEMI with and without diabetes. METHODS: This study included 115 patients with STEMI, 86 (74...
April 2010: Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review
https://www.readbyqxmd.com/read/20095517/-risk-factors-for-coronary-heart-disease-and-actual-diagnostic-criteria-for-diabetes-mellitus
#12
Natasa Mitrović-Perisić, Slobodan Antić
BACKGROUND/AIM: Recent studies indicate that the prevalence of diabetes mellitus (DM) type 2 is increasing in the world. Chronic hyperglycemia in DM is associated with a long term damage, dysfunction and failure of various organs, especially retina, kidney, nerves and, in addition, with an increased risk of cardiovascular disease. For a long time the illness has been unknown. Early diagnosis of diabetes could suspend the development of diabetic complications. The aim of the study was to establish risk for the development of coronary disease in the patients evaluated by the use of new dignostic criteria for DM...
December 2009: Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review
https://www.readbyqxmd.com/read/19774736/spontaneous-rupture-of-spleen-histological-immunohistochemical-and-ultrastructural-study
#13
Giovanna Giordano, Letizia Gnetti
Pathological examination in the spleen of an 81-year old female with hemoperitoneum, hypovolemic shock, anemia, thrombocytopenia and hyperglicemia revealed the presence of an angiosarcoma. On histological examination, characteristically the neoplasm was formed by vascular lumina and cystic spaces into which papillary fronds projected and solid nests. Neoplastic cells had scant cytoplasm, hyperchromatic, oval or reniform nuclei, with prominent nucleoli. The necrosis was evident and mitoses were frequent. Immunohistochemical analysis revealed positivity for endothelial (CD31, CD34) and histiocytic markers (CD68 and lysozyme) and negativity for CD21...
January 2003: Advances in Clinical Pathology: the Official Journal of Adriatic Society of Pathology
https://www.readbyqxmd.com/read/19675514/serum-ghrelin-levels-and-disturbances-of-the-lipid-profile-in-patients-with-acromegaly
#14
Magdalena Jaskula, Ryszard Wasko, Hanna Komarowska, Aleksandra Dziubandowska, Jerzy Sowinski
UNLABELLED: It is unknown if altered ghrelin secretion might contribute to the development of metabolic complications in acromegaly. The AIM OF THE STUDY was to: 1) assess if serum concentrations of total and acylated ghrelin in patients with acromegaly differ in the presence of various metabolic complications (hypercholesterolemia, hyperinsulinemia, hyperglicemia). 2) assess the correlations between concentrations of ghrelin and concentrations of GH, IGF-1, cholesterol, insulin and glucose in patients with acromegaly...
2009: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/19260377/incretin-based-therapies-a-new-potential-treatment-approach-to-overcome-clinical-inertia-in-type-2-diabetes
#15
REVIEW
Antonio Nicolucci, Maria Chiara Rossi
Maintaining an adequate metabolic control is still a challenge in many patients with type 2 diabetes. Among the many factors advocated to explain the failure to achieve recommended goals, clinical inertia is increasingly recognised as a primary cause of poor glycaemic control. The existence of a "metabolic memory" strongly supports the adoption of a more aggressive treat-to-target approach, instead of waiting for treatment failure. This approach may be particularly important in the initial phases of the disease, to slow the progressive decline of beta-cell function and improve overall outcomes...
December 2008: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/18850175/chronic-hyperglicemia-and-nitric-oxide-bioavailability-play-a-pivotal-role-in-pro-atherogenic-vascular-modifications
#16
Assunta Pandolfi, Elena Anna De Filippis
Diabetes is associated with accelerated atherosclerosis and macrovascular complications are a major cause of morbidity and mortality in this disease. Although our understanding of vascular pathology has lately greatly improved, the mechanism(s) underlying enhanced atherosclerosis in diabetes remain unclear. Endothelial cell dysfunction is emerging as a key component in the pathophysiology of cardiovascular abnormalities associated with diabetes. Although it has been established that endothelium plays a critical role in overall homeostasis of the vessels, vascular smooth muscle cells (vSMC) in the arterial intima have a relevant part in the development of atherosclerosis in diabetes...
November 2007: Genes & Nutrition
https://www.readbyqxmd.com/read/18845702/sources-of-protein-and-polyunsaturated-fatty-acids-of-the-diet-and-microalbuminuria-in-type-2-diabetes-mellitus
#17
Jussara C Almeida, Themis Zelmanovitz, Juliana S Vaz, Thais Steemburgo, Magda S Perassolo, Jorge L Gross, Mirela J Azevedo
BACKGROUND: Albuminuria excretion rate above the reference range and below albustix positive proteinuria (20-199 microg/min) is known as microalbuminuria and has been associated with an increased risk of death and progression to renal failure. Besides hyperglicemia and high blood pressure levels, dietary factors can also influence albuminuria. OBJECTIVE: To evaluate possible associations of dietary components (macronutrients and selected foods) with microalbuminuria in type 2 diabetic patients...
October 2008: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/18293844/-the-influence-of-hyperglycemia-on-oxidation-reduction-reaction-of-human-umbilical-vein-endothelial-cells
#18
Marek Szczepański, Monika Kamianowska, Elzbieta Skrzydlewska
UNLABELLED: Hyperglicemia is recognised as a primal factor responsible for microcirculatory changes in diabetic patients. There exist many reasons to claim that high glucose concentrations, generating reactive oxygen species (ROS), induce oxidative stress which initiates peroxidation processes. The end products of lipids peroxidation (aldehydes) cause disturbances of cellular membrane structures, its depolarization, inhibition of membrane's enzymes activity, indicating loss of cellular membrane integrity and uncoupling of oxidative phosphorylation in mitochondria...
October 2007: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/18173174/-interleukin-1-receptor-antagonists-prevent-the-induction-of-experimental-insulin-dependent-autoimmune-diabetes
#19
S Stosić-Grujicić, M Lukić, N Ostajić
During the induction of diabetes with multiple low-dose of streptozotocin (40-45 mg/kg body weigh for 5 consecutive days) starting from day 3, CBA mice were injected repeatedly (10 daily injections) with either rat IL-1 inhibitor (IL-1 INH) derived from glucocorticoid-treated macrophages, or with recombinant DNA produced human IL-1 receptor antagonist (rIL-1ra). Althow not showing identity with each other, both agents by neutralisation of the activity of endogenous IL-1 interfered with the induction of diabetes...
1994: Srpski Arhiv za Celokupno Lekarstvo
https://www.readbyqxmd.com/read/17633894/-the-role-of-insulin-analogues-in-the-current-treatment-of-diabetes-mellitus
#20
REVIEW
Milena Mitrović, Pavle Pantelinac, Jovanka Radosavljević, Ivana Bajkin, Ljiljana Todorović-Dilas
INTRODUCTION: Ever since insulin was discovered by Banting and Best in 1921, all further researches in this field had been conducted with one goal: to find new insulin molecules which would provide better glycemic control with fewer side effects i.e. to mimic endogenous physiological insulin secretion. NORMAL INSULIN SECRETION: In healthy individuals, endogenous insulin secretion can be classified as basal (which provides basal glucose homeostasis) and stimulated (as a response to a meal)...
November 2006: Medicinski Pregled
keyword
keyword
45091
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"