keyword
https://read.qxmd.com/read/38488442/erucin-a-natural-isothiocyanate-exerts-pro-angiogenic-properties-in-cultured-endothelial-cells-and-reverts-angiogenic-impairment-induced-by-high-glucose
#1
JOURNAL ARTICLE
Shirley Genah, Valerio Ciccone, Arianna Filippelli, Vittoria Simonis, Alma Martelli, Eugenia Piragine, Eleonora Pagnotta, Nicola Pecchioni, Vincenzo Calderone, Lucia Morbidelli
Insufficient vessel maintenance adversely impacts patients in terms of tissue reperfusion following stroke or myocardial infarction, as well as during wound healing. Angiogenesis impairment is a feature typical of metabolic disorders acting at the cardiovascular level, such as diabetes. Therapeutic angiogenesis regulation offers promising clinical implications, and natural compounds as pro-angiogenic nutraceuticals hold valuable applications in regenerative medicine. By using cultured endothelial cells from human umbilical veins (HUVEC) we studied functional and molecular responses following exposure to erucin, a natural isothiocyanate derived from Brassicaceae plants and extracted from the seeds of rocket...
March 15, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38364941/leishmania-amazonensis-infection-regulates-oxidate-stress-in-hyperglycemia-and-diabetes-impairing-macrophage-s-function-and-immune-response
#2
JOURNAL ARTICLE
Taylon Felipe Silva, Mariana Barbosa Detoni, Virgínia Márcia Concato, Fernanda Tomiotto-Pellissier, Milena Menegazzo Miranda-Sapla, Bruna Taciane da Silva Bortoleti, Manoela Daiele Gonçalves, Ana Carolina Jacob Rodrigues, Raquel Arruda Sanfelice, Ellen Mayara Souza Cruz, Maria Stacy Dos Santos Silva, Amanda Cristina Machado Carloto, Danielle Lazarin Bidoia, Idessania Nazareth Costa, Wander Rogério Pavanelli, Ivete Conchon-Costa
UNLABELLED: Leishmaniasis is a group of infectious diseases caused by protozoa of the Leishmania genus and its immunopathogenesis results from an unbalanced immune response during the infection. Diabetes is a chronic disease resulting from dysfunction of the body's production of insulin or the ability to use it properly, leading to hyperglycemia causing tissue damage and impairing the immune system. AIMS: The objective of this work was to evaluate the effects of hyperglycemia and diabetes during Leishmania amazonensis infection and how these conditions alter the immune response to the parasite...
February 14, 2024: Biochimica et Biophysica Acta. Molecular Basis of Disease
https://read.qxmd.com/read/37645417/case-report-post-gastrectomy-reactive-hyperinsulinemic-hypoglicaemia-glucose-trends-before-and-after-canagliflozin-treatment
#3
G Bellastella, P Caruso, C Carbone, M di Nuzzo, L Scappaticcio, V Amoresano Paglionico, M I Maiorino, K Esposito
The pathogenesis of post-gastrectomy reactive hyperinsulinaemic hypoglycaemia is not yet fully clarified. Recent studies suggest an up-regulation of the intestinal glucose transporter SGLT-1 aimed to prevent carbohydrate malabsorption. The overexpression of SGLT-1 could therefore represents one of the mechanisms underlying the wide glycemic excursions found in patients after gastrectomy, but studies investigating the use of SGLT-1/SGLT-2 inhibitors in patients with post-gastrectomy reactive hyperinsulinemic hypoglycaemia are very scant in the literature...
2023: Frontiers in Endocrinology
https://read.qxmd.com/read/35937825/altered-regional-homogeneity-in-patients-with-diabetic-erectile-dysfunction-a-resting-state-fmri-study
#4
JOURNAL ARTICLE
Jianhuai Chen, Xinfei Huang, Qinglai Tang, Ziliang Xiang, Yan Xu, Tao Liu, Zhaoxu Yang, Jie Yang, Yun Chen
Introduction: Erectile dysfunction (ED) is a common complication of Type-2 Diabetes Mellitus (T2DM) for male patients and it is considered to be associated with different causes including hyperglicemia-induced vascular endothelial cell damages. However, the possible central neural mechanisms shared by these two diseases remain unclear. This study aimed to explore the changes of brain activity and their relationships with the clinical characteristics in patients with diabetic ED. Methods: The data of resting-state functional magnetic resonance imaging were acquired in 31 T2DM patients with ED (DM-ED) and 31 matched healthy controls (HCs)...
2022: Frontiers in Endocrinology
https://read.qxmd.com/read/35801596/liquid-biopsy-as-a-tool-for-predicts-of-severe-covid-19-and-hospitalised-community-acquired-pneumonia
#5
JOURNAL ARTICLE
Irina Komarevtseva, Anna Ihnatova, Irina Rudenko, Kateryna Balabanova, Vitaliy Komarevtsev
Cell-free DNA (cfDNA) is released into the circulation after apoptosis, necrosis, and active secretion from cells. In a healthy individual, cfDNA is present in small amounts, has a short half-life, and is predominantly derived from circulating hematopoietic cells. The composition and quantity of cfDNA dramatically changes during pathological conditions. Indeed, several studies reported elevated cfDNA concentration as a potential noninvasive biomarker in many diseases. AIM: The aim of the study was evaluation of the circulating cell-free DNA in patients with severe Covid-19 in comparison with patients with hospitalised community-acquired pneumonia (with and without hyperglycemia and type 2 diabetes mellitus) to determine the specificity, sensitivity and cutoff value of cfDNA for each nosology...
June 24, 2022: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://read.qxmd.com/read/35133551/redefining-diabetes-mellitus-treatments-according-to-different-mechanisms-beyond-hypoglycaemic-effect
#6
REVIEW
Savina Nodari, Francesco Fioretti, Francesco Barilla
Early epidemiologic studies in type 2 diabetes suggested that the long-term risk of microvascular and macrovascular complications increase progressively as glucose concentrations rise, inspiring the pursuit of near euglycaemia as a means of preventing these complications in type 1 and type 2 diabetes. Evidence emerging over the past decade, however, showed that the aggressive efforts often needed to achieve low HbA1c levels can ultimately lead to worse clinical outcomes, greater risk of severe hypoglycaemia, and higher burden of treatment...
February 8, 2022: Heart Failure Reviews
https://read.qxmd.com/read/34999572/respiratory-consequences-of-obesity-and-diabetes
#7
JOURNAL ARTICLE
Barbara Nóra Kovács, Roberta Südy, Ferenc Peták, Ádám László Balogh, H Gergely Fodor, József Tolnai, Anita Korsós, Álmos Schranc, Csaba Lengyel, Barna Babik
Összefoglaló. Bevezetés: A cukorbetegségben nő a simaizmok tónusa, és megváltozik az elasztin és a kollagén szerkezete. Mivel a tüdőszövetben ezek a strukturális elemek meghatározóak, a cukorbetegség várhatóan módosítja a légutak és a tüdőszövet mechanikai és funkcionális viselkedését. Célkitűzés: Vizsgálatunk során diabetesben szenvedő, elhízott és nem elhízott betegeink körében tanulmányoztuk a légzésmechanikai elváltozásokat és a gázcserefunkciót. Módszer: Elektív szívsebészeti beavatkozásra kerülő, normál testalkatú betegeket diabetesben nem szenvedő (n = 80), illetve cukorbeteg (n = 35) csoportokra osztottuk...
January 9, 2022: Orvosi Hetilap
https://read.qxmd.com/read/34474958/predictors-of-long-term-mortality-in-left-sided-infective-endocarditis-an-historical-cohort-study-in-414-patients
#8
JOURNAL ARTICLE
Emanuele Durante-Mangoni, Giuseppe Giuffrè, Maria Paola Ursi, Domenico Iossa, Lorenzo Bertolino, Alessandra Senese, Pia Clara Pafundi, Fabiana D'Amico, Rosina Albisinni, Rosa Zampino
INTRODUCTION: Very limited data are available on the long-term outcome of infective endocarditis (IE) and its determinants. The aim of this study was to identify the predictors of long-term mortality in patients affected by left sided IE (LSIE). METHODS: This was an historical retrospective observational study on prospectively collected data from patients with LSIE hospitalized in our Unit (January 2000-December 2017). Multiple variables relevant to history, physical examination, laboratory tests, echocardiography, comorbidities, complications and outcome were analysed by Cox regression to identify predictors of long-term mortality...
August 30, 2021: European Journal of Internal Medicine
https://read.qxmd.com/read/33484412/prevalence-of-less-severe-hypercortisolism-in-fractured-patients-admitted-in-an-outpatient-clinic-for-metabolic-bone-diseases
#9
JOURNAL ARTICLE
F Pugliese, A S Salcuni, C Battista, V Carnevale, G Guglielmi, C Columbu, F Velluzzi, L Giovanelli, C Eller-Vainicher, A Scillitani, I Chiodini
PURPOSE: To evaluate the prevalence of less severe hypercortisolism (LSH) in fractured patients, and its association with hypertension, hyperglicemia, dyslipidemia, and obesity. METHOD: From July 2015 to October 2018 we enrolled all fractured patients admitted in our outpatient center for metabolic bone diseases, after exclusion of patients with secondary osteoporosis apart from diabetes and taking drugs known to affect bone metabolism. In all enrolled patients we collected data regarding gonadal status, history of diabetes, high blood pressure, dyslipidemia, and measured blood pressure, lipid profile, fasting glycaemia...
July 2021: Endocrine
https://read.qxmd.com/read/29894646/methylene-blue-alleviates-endothelial-dysfunction-and-reduces-oxidative-stress-in-aortas-from-diabetic-rats
#10
JOURNAL ARTICLE
Andreea I Privistirescu, Alexandra Sima, Oana M Duicu, Romulus Timar, Mariana G Roșca, Adrian Sturza, Danina M Muntean
Endothelial dysfunction and the related increase in reactive oxygen species (ROS) production are important events in the pathophysiology of diabetes mellitus (DM). Methylene blue (MB) has been systematically investigated for its protective effects against refractory hypotension and mitochondrial dysfunction. We have previously demonstrated that MB improved mitochondrial respiration and partially decreased oxidative stress in diabetic rat hearts. The present study was aimed to investigate whether MB modulates vascular function and ROS production in thoracic aortic rings isolated from rats with streptozotocin-induced DM (after 4 weeks of hyperglycemia)...
October 2018: Canadian Journal of Physiology and Pharmacology
https://read.qxmd.com/read/29807099/metabolic-syndrome-and-cancer-the-common-soil-hypothesis
#11
REVIEW
Giuseppe Bellastella, Lorenzo Scappaticcio, Katherine Esposito, Dario Giugliano, Maria Ida Maiorino
Metabolic syndrome (MetS) and cancer share many modifiable risk factors including age, genetic factors, obesity, physical inactivity, unhealthy diet, alcohol, smoking, endocrine disruptors exposure, circadian clock disturbances, and air pollution. MetS is closely linked to cancer, as it increases cancer risk and cancer-related mortality; moreover, cancer survivors have an increased risk of MetS. Elucidating the mechanisms linking MetS to cancer is important to prevent or delay these two conditions. Possible mechanisms explaining the relationship between MetS and cancer include hyperinsulinemia and alterations of insulin-like growth factor system, chronic subclinical inflammation, abnormalities in sex hormones metabolism and adipokines, hyperglicemia, alterations in both gene expression and hormonal profile by endocrine disruptors and air pollution, desynchronization of circadian clock...
September 2018: Diabetes Research and Clinical Practice
https://read.qxmd.com/read/28710042/new-evidence-for-causal-central-mechanism-of-hyperglycemia-in-subarachnoid-hemorrhage-secondary-to-ischemic-degenerative-disruption-of-circuitry-among-insular-cortex-nodose-ganglion-and-pancreas-experimental-study
#12
JOURNAL ARTICLE
Mehmet Dumlu Aydın, Ayhan Kanat, Nazan Aydın, Abdulmecit Kantarci, Muhammet Ali Ayvaz, Halil Rakici, Coskun Yolas, Umit Kepoglu, Elif Demirci
INTRODUCTION: Although hyperglycemia is a serious complication of subarachnoid hemorrhage, its pathophysiologic mechanism based on neural circuitry has not been known. MATERIALS AND METHODS: Twenty-five rabbits were divided into 4 groups, with 5 in the control group. The SHAM and study groups received 1 mL saline and 1 mL autologous arterial blood into the sylvian cisterna, respectively. Blood glucose values (BGVs) of all animals were recorded 3 times weekly. After 2 weeks, animals were decapitated...
October 2017: World Neurosurgery
https://read.qxmd.com/read/28215148/effects-of-tea-and-coffee-consumption-on-cardiovascular-diseases-and-relative-risk-factors-an-update
#13
REVIEW
Arianna Di Lorenzo, Valeria Curti, Gian C Tenore, Seyed M Nabavi, Maria Daglia
BACKGROUND: Tea and coffee are the second and third most consumed beverages after water, respectively. The high consumption of these beverages is due to the sensorial properties and effects on psychological and physiological functions, induced by caffeine and many other bioactive components responsible for the protective effects on human health generally ascribed to these beverages. METHODS: The goal of this review article is to collect the scientific data obtained from clinical trials published in the last five years on the role of tea and coffee consumption against cardiovascular diseases (CVDs) and CVD risk factors such as hypertension, hyperglicemia, and hyperlipidaemia...
2017: Current Pharmaceutical Design
https://read.qxmd.com/read/27354525/epigenetics-and-energetics-in-ventral-hippocampus-mediate-rapid-antidepressant-action-implications-for-treatment-resistance
#14
JOURNAL ARTICLE
Benedetta Bigio, Aleksander A Mathé, Vasco C Sousa, Danielle Zelli, Per Svenningsson, Bruce S McEwen, Carla Nasca
Although regulation of energy metabolism has been linked with multiple disorders, its role in depression and responsiveness to antidepressants is less known. We found that an epigenetic and energetic agent, acetyl-l-carnitine (LAC, oral administration), rapidly rescued the depressive- and central and systemic metabolic-like phenotype of LAC-deficient Flinders Sensitive Line rats (FSL). After acute stress during LAC treatment, a subset of FSL continued to respond to LAC (rFSL), whereas the other subset did not (nrFSL)...
July 12, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/27097010/diabetic-hemichorea-hemiballismus-with-nonketotic-hyperglicemia-a-rare-cause-of-hyperkinetic-movement-disorders
#15
JOURNAL ARTICLE
Lucas Giansante Abud, Thiago Giansante Abud, Rodolfo Mendes Queiroz, Giovanni Salton Pietroni, Daniel Giansante Abud
No abstract text is available yet for this article.
April 2016: Arquivos de Neuro-psiquiatria
https://read.qxmd.com/read/26343077/age-abdominal-obesity-and-glycated-hemoglobin-are-associated-with-carotid-atherosclerosis-in-type-2-diabetes-patients-with-nonalcoholic-fatty-liver-disease
#16
JOURNAL ARTICLE
Cristina Alina Silaghi, Horațiu Silaghi, Anca Elena Crăciun, Anca Fărcaș, Horațiu Alexandru Colosi, Daniel Tudor Cosma, Raluca Pais, Nicolae Hâncu, Carmen Emanuela Georgescu
AIM: The aim of this study was to evaluate the impact of clinical parameters and indices of body composition on the relation between non-alcoholic fatty liver disease (NAFLD) and carotid intima-media thickness (cIMT), in a type 2 diabetes mellitus population (T2DM). MATERIAL AND METHODS: We retrospectively enrolled 336 T2DM outpatients who regularly attended Regina Maria Clinic in Cluj. Clinical, anthropometric and biochemical parameters were measured. Ultrasonography (US) was used to assess hepatic steatosis (HS) in all patients and cIMT in 146 subjects...
September 2015: Medical Ultrasonography
https://read.qxmd.com/read/24794552/protein-kinase-c-in-enhanced-vascular-tone-in-diabetes-mellitus
#17
REVIEW
Igor V Kizub, Kateryna I Klymenko, Anatoly I Soloviev
Diabetes mellitus (DM) is a complex syndrome which leads to multiple dysfunctions including vascular disorders. Hyperglycemia is considered to be a key factor responsible for the development of diabetic vascular complications and can mediate their adverse effects through multiple pathways. One of those mechanisms is the activation of protein kinase C (PKC). This important regulatory enzyme is involved in a signal transduction of several vascular functions including vascular smooth muscle contractility. Many studies have shown that hyperglycemia in DM results in oxidative stress...
June 15, 2014: International Journal of Cardiology
https://read.qxmd.com/read/24640089/-features-of-early-stages-of-cardiovascular-continuum-in-workers-engaged-in-oil-extracting-enterprise
#18
JOURNAL ARTICLE
A E Nosov, A S Baĭdina, O Iu Ustinova
The authors present data on metabolic disorders and vascular state in workers of oil extracting enterprise, exposed to complex of occupational hazards (noise, work hardiness, chemical factors). Major role among chemical hazards is played by aromatic hydrocarbons. In clinical and epidemiologic studies, arterial hypertension was reliably more frequent in a group of oil extraction workers. Findings are that oil extraction workers, when compared to the reference group, demonstrate more marked metabolic disorders (dyslipidemia with increased total cholesterol and low density lipoproteins, hyperuricemia, hyperglicemia, increased lipids peroxidation) with endothelial dysfunction...
2013: Meditsina Truda i Promyshlennaia Ekologiia
https://read.qxmd.com/read/23724531/comparison-of-hba1c-levels-in-obese-and-non-obese-polycystic-ovarian-patients
#19
COMPARATIVE STUDY
A N Unluer, R B Findik, N Sevinc, J Karakaya
AIM: To compare obese and non-obese polycystic ovary syndrome (PCOS) patients with respect to lipid profile, hormone profiles, and hemoglobin A1c (HbA1c) values indicating chronic hyperglicemia. MATERIALS AND METHODS: Thirty PCOS patients with a body mass index (BMI) > 25 and 35 non-obese PCOS patients with BMI < 25 were compared with regard to basal luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin (PRL), estradiol (E2), fasting blood sugar (FBS), low-density lipoprotein (LDL), high-density lipoprotein (HDL), total cholesterol (TCOL), triglyceride (TG), and HbA1c values...
2013: Clinical and Experimental Obstetrics & Gynecology
https://read.qxmd.com/read/23073120/is-prediabetes-risk-factor-for-hair-loss
#20
JOURNAL ARTICLE
Evrim Cakir
In the recent hypothesis that hair loss might be a manifestation of metabolic abnormalities particularly hyperglicemia. It has been reported various environmental risk factors affecting hair loss. There is growing evidence on the relationship between prediabetes and worse metabolic profile. However, there are few studies about the association between hair loss, metabolic disorder and diabetes. Therefore patients that admitted the hospital with hair loss should be screened for diabetes mellitus and prediabetes...
December 2012: Medical Hypotheses
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