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https://www.readbyqxmd.com/read/29668050/long-term-outcome-of-selective-neurectomy-for-refractory-periocular-synkinesis
#1
Martinus M van Veen, Joseph R Dusseldorp, Tessa A Hadlock
OBJECTIVE: The objective of this study was to investigate the long-term effect and treatment stability of selective neurectomy for refractory periocular synkinesis. METHODS: We performed a retrospective review of all patients treated with highly selective neurectomy for refractory periocular synkinesis between August 2009 and August 2015. Primary outcome was time to recommencing treatment for periocular synkinesis. Palpebral fissure width was measured preoperatively, postoperatively, and at long-term ( > 2...
April 18, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29667181/the-specific-social-costs-of-expressive-negative-symptoms-in-schizophrenia-reduced-smiling-predicts-interactional-outcome
#2
M Riehle, S Mehl, T M Lincoln
OBJECTIVE: We tested whether people with schizophrenia and prominent expressive negative symptoms (ENS) show reduced facial expressions in face-to-face social interactions and whether this expressive reduction explains negative social evaluations of these persons. METHOD: We compared participants with schizophrenia with high ENS (n = 18) with participants with schizophrenia with low ENS (n = 30) and with healthy controls (n = 39). Participants engaged in an affiliative role-play that was coded for the frequency of positive and negative facial expression and rated for social performance skills and willingness for future interactions with the respective role-play partner...
April 17, 2018: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29667144/efficacy-and-safety-of-zofenopril-versus-ramipril-in-the-treatment-of-myocardial-infarction-and-heart-failure-a-review-of-the-published-and-unpublished-data-of-the-randomized-double-blind-smile-4-study
#3
REVIEW
Claudio Borghi, Stefano Omboni, Salvatore Novo, Dragos Vinereanu, Giuseppe Ambrosio, Ettore Ambrosioni
Zofenopril is a lipophilic, sulfhydryl group-containing angiotensin-converting enzyme (ACE)-inhibitor, characterized by wide tissue distribution, long duration of action, and pleiotropic effects on endothelial dysfunction. Its clinical efficacy and safety have been described in the four randomized controlled trials of the SMILE program, which globally enrolled more than 3600 patients in post-acute myocardial infarction (AMI) setting. The SMILE-4 study specifically selected patients with left ventricular dysfunction at admission, and compared the effects of zofenopril or ramipril in combination with acetylsalicylic acid (ASA)...
April 17, 2018: Advances in Therapy
https://www.readbyqxmd.com/read/29662855/a-weeping-ulcer-that-vanished-with-a-smile
#4
Ankur Jain, Gaurav Prakash, Amanjit Bal, Pankaj Malhotra, Subhash Varma
No abstract text is available yet for this article.
March 2018: Blood Research
https://www.readbyqxmd.com/read/29662037/towards-the-development-of-global-nano-quantitative-structure-property-relationship-models-zeta-potentials-of-metal-oxide-nanoparticles
#5
Andrey A Toropov, Natalia Sizochenko, Alla P Toropova, Jerzy Leszczynski
Zeta potential indirectly reflects a charge of the surface of nanoparticles in solutions and could be used to represent the stability of the colloidal solution. As processes of synthesis, testing and evaluation of new nanomaterials are expensive and time-consuming, so it would be helpful to estimate an approximate range of properties for untested nanomaterials using computational modeling. We collected the largest dataset of zeta potential measurements of bare metal oxide nanoparticles in water (87 data points)...
April 15, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29658989/the-effectiveness-of-a-group-self-management-education-course-for-adults-with-poorly-controlled-epilepsy-smile-uk-a-randomized-controlled-trial
#6
Leone Ridsdale, Gabriella Wojewodka, Emily J Robinson, Adam J Noble, Myfanwy Morgan, Stephanie J C Taylor, Paul McCrone, Mark P Richardson, Gus Baker, Sabine Landau, Laura H Goldstein
OBJECTIVE: Epilepsy is one of the most common neurological conditions affecting about 1% of adults. Up to 40% of people with epilepsy (PWE) report recurring seizures while on medication. And optimal functioning requires good self-management. Our objective was to evaluate a group self-management education courses for people with epilepsy and drug-resistant seizures by means of a multicenter, pragmatic, parallel group, randomized controlled trial. METHODS: We recruited adults with epilepsy, having ≥2 seizures in the prior 12 months, from specialist clinics...
April 16, 2018: Epilepsia
https://www.readbyqxmd.com/read/29658373/talking-emotions-vowel-selection-in-fictional-names-depends-on-the-emotional-valence-of-the-to-be-named-faces-and-objects
#7
Ralf Rummer, Judith Schweppe
One prestudy based on a corpus analysis and four experiments in which participants had to invent novel names for persons or objects (N = 336 participants in total) investigated how the valence of a face or an object affects the phonological characteristics of the respective novel name. Based on the articulatory feedback hypothesis, we predicted that /i:/ is included more frequently in fictional names for faces or objects with a positive valence than for those with a negative valence. For /o:/, the pattern should reverse...
April 16, 2018: Cognition & Emotion
https://www.readbyqxmd.com/read/29658366/a-novel-case-using-femtosecond-laser-acquired-lenticule-for-recurrent-pterygium-case-report-and-literature-review
#8
Om Prakash Pant, Ji-Long Hao, Dan-Dan Zhou, Fan Wang, Cheng-Wei Lu
Small incision lenticule extraction (SMILE) is a minimally invasive, safe and flapless femtosecond laser technique used mainly to correct myopia through extraction of a corneal lenticule. Lenticules obtained in this way are transparent and of high quality, and thus, can be used to treat other corneal diseases. A 65-year-old male patient presented with recurrent pterygium complicated by thin cornea. The patient was treated surgically using a SMILE-extracted lenticule to avoid further complications and to maintain eyeball integrity...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29657085/structural-determinants-for-small-molecule-activation-of-skeletal-muscle-ampk-%C3%AE-2%C3%AE-2%C3%AE-1-by-the-glucose-importagog-sc4
#9
Kevin R W Ngoei, Christopher G Langendorf, Naomi X Y Ling, Ashfaqul Hoque, Swapna Johnson, Michelle C Camerino, Scott R Walker, Ylva E Bozikis, Toby A Dite, Ashley J Ovens, William J Smiles, Roxane Jacobs, He Huang, Michael W Parker, John W Scott, Mark H Rider, Richard C Foitzik, Bruce E Kemp, Jonathan B Baell, Jonathan S Oakhill
The AMP-activated protein kinase (AMPK) αβγ heterotrimer regulates cellular energy homeostasis with tissue-specific isoform distribution. Small-molecule activation of skeletal muscle α2β2 AMPK complexes may prove a valuable treatment strategy for type 2 diabetes and insulin resistance. Herein, we report the small-molecule SC4 is a potent, direct AMPK activator that preferentially activates α2 complexes and stimulates skeletal muscle glucose uptake. In parallel with the term secretagog, we propose "importagog" to define a substance that induces or augments cellular uptake of another substance...
April 7, 2018: Cell Chemical Biology
https://www.readbyqxmd.com/read/29655527/the-smiling-scan-technique-facially-driven-guided-surgery-and-prosthetics
#10
Alessandro Pozzi, Lorenzo Arcuri, Peter K Moy
PURPOSE: To introduce a proof of concept technique and new integrated workflow to optimize the functional and esthetic outcome of the implant-supported restorations by means of a 3-dimensional (3D) facially-driven, digital assisted treatment plan. METHODS: The Smiling Scan technique permits the creation of a virtual dental patient (VDP) showing a broad smile under static conditions. The patient is exposed to a cone beam computed tomography scan (CBCT), displaying a broad smile for the duration of the examination...
April 11, 2018: Journal of Prosthodontic Research
https://www.readbyqxmd.com/read/29652571/hemolasertherapy-a-novel-procedure-for-gingival-papilla-regeneration-case-report
#11
Fatima Zanin, Maria Stella Moreira, Ana Clara Fagundes Pedroni, Mateus Windlin, Ana Paula Brugnera, Aldo Brugnera Júnior, Marcia Martins Marques
BACKGROUND: Interdental papilla is of major importance to patients' orofacial aesthetics, especially regarding anterior teeth as part of the smile's harmony. Loss of gingival tissue, which constitutes interdental papilla, forms what in odontology is called black spaces. This loss, besides affecting the smile's aesthetics, also provokes phonetic and functional damage. OBJECTIVE: The objective of the authors is to present the result of three clinical cases treated with an innovative technique called hemolasertherapy, which stimulates growth of gingival papilla and thus permanently fills in the black spaces...
April 2018: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/29649064/incomplete-facial-paralysis-the-use-of-the-ipsilateral-residual-facial-nerve-as-a-donor-nerve-for-facial-reanimation
#12
Eyal Gur, Ron M Zuker, Arik Zaretski, David Leshem, Yoav Barnea, Ehud Arad, Ravit Yanko, Beni Meilik, Daniel J Kedar, Ehud Fliss
BACKGROUND: The reconstructive approach for incomplete facial paralysis is not yet determined. In this article we present a new surgical approach for patients with incomplete facial paralysis in which residual, ineffective movement is detected pre-operatively in the ipsilateral bucco-zygomatic territory of the paretic facial nerve. METHODS: Sixteen patients with incomplete facial paralysis were found eligible for the procedure and underwent one-stage facial reanimation by the senior author (E...
March 29, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29648917/successful-treatment-of-systemic-ebv-positive-t-cell-lymphoma-of-childhood-using-the-smile-regimen
#13
Masanori Yoshida, Tomoo Osumi, Ken-Ichi Imadome, Daisuke Tomizawa, Motohiro Kato, Noritaka Miyazawa, Reiko Ito, Atsuko Nakazawa, Kimikazu Matsumoto
No abstract text is available yet for this article.
April 12, 2018: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/29644568/smiling-faces-and-cash-bonuses-exploring-common-affective-coding-across-positive-and-negative-emotional-and-motivational-stimuli-using-fmri
#14
Haeme R P Park, Mariam Kostandyan, C Nico Boehler, Ruth M Krebs
Although it is clear that emotional and motivational manipulations yield a strong influence on cognition and behaviour, these domains have mostly been investigated in independent research lines. Therefore, it remains poorly understood how far these affective manipulations overlap in terms of their underlying neural activations, especially in light of previous findings that suggest a shared valence mechanism across multiple affective processing domains (e.g., monetary incentives, primary rewards, emotional events)...
April 11, 2018: Cognitive, Affective & Behavioral Neuroscience
https://www.readbyqxmd.com/read/29644238/mechanisms-of-optical-regression-following-corneal-laser-refractive-surgery-epithelial-and-stromal-responses
#15
REVIEW
Majid Moshirfar, Jordan D Desautels, Brian D Walker, Michael S Murri, Orry C Birdsong, Phillip C Hoopes
Laser vision correction is a safe and effective method of reducing spectacle dependence. Photorefractive Keratectomy (PRK), Laser In Situ Keratomileusis (LASIK), and Small-Incision Lenticule Extraction (SMILE) can accurately correct myopia, hyperopia, and astigmatism. Although these procedures are nearing optimization in terms of their ability to produce a desired refractive target, the long term cellular responses of the cornea to these procedures can cause patients to regress from the their ideal postoperative refraction...
2018: Medical Hypothesis, Discovery and Innovation in Ophthalmology
https://www.readbyqxmd.com/read/29644011/modeling-multiple-time-series-annotations-as-noisy-distortions-of-the-ground-truth-an-expectation-maximization-approach
#16
Rahul Gupta, Kartik Audhkhasi, Zach Jacokes, Agata Rozga, Shrikanth Narayanan
Studies of time-continuous human behavioral phenomena often rely on ratings from multiple annotators. Since the ground truth of the target construct is often latent, the standard practice is to use ad-hoc metrics (such as averaging annotator ratings). Despite being easy to compute, such metrics may not provide accurate representations of the underlying construct. In this paper, we present a novel method for modeling multiple time series annotations over a continuous variable that computes the ground truth by modeling annotator specific distortions...
January 2018: IEEE Transactions on Affective Computing
https://www.readbyqxmd.com/read/29629133/fast-and-accurate-prediction-of-the-regioselectivity-of-electrophilic-aromatic-substitution-reactions
#17
Jimmy C Kromann, Jan H Jensen, Monika Kruszyk, Mikkel Jessing, Morten Jørgensen
While computational prediction of chemical reactivity is possible it usually requires expert knowledge and there are relatively few computational tools that can be used by a bench chemist to help guide synthesis. The RegioSQM method for predicting the regioselectivity of electrophilic aromatic substitution reactions of heteroaromatic systems is presented in this paper. RegioSQM protonates all aromatic C-H carbon atoms and identifies those with the lowest free energies in chloroform using the PM3 semiempirical method as the most nucleophilic center...
January 21, 2018: Chemical Science
https://www.readbyqxmd.com/read/29625866/mixed-facial-reanimation-technique-to-treat-paralysis-in-medium-term-cases
#18
Federico Biglioli, Federico Bolognesi, Fabiana Allevi, Dimitri Rabbiosi, Silvia Cupello, Antonino Previtera, Alessandro Lozza, Valeria M A Battista, Claudio Marchetti
Recent facial paralyses, in which fibrillations of the mimetic muscles are still detectable by electromyography (EMG), allow facial reanimation based on giving new neural stimuli to musculature. However, if more time has elapsed, mimetic muscles can undergo irreversible atrophy, and providing a new neural stimulus is simply not effective. In these cases function is provided by transferring free flaps into the face or transposing masticatory muscles to reinstitute major movements, such as eyelid closure and smiling...
March 14, 2018: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29624630/changes-in-quality-of-life-induced-by-tooth-whitening-are-moderated-by-perfectionism-a-randomized-double-blind-placebo-controlled-trial
#19
Daniela Kovacevic Pavicic, Marija Kolceg, Vlatka Lajnert, Andrej Pavlic, Martina Brumini, Stjepan Spalj
PURPOSE: To explore the influence of perfectionism on the short-term changes in satisfaction with smile esthetics and quality of life (QoL) induced by tooth whitening. MATERIALS AND METHODS: A total of 60 subjects were analyzed: 30 in the active group, in which the subject's anterior teeth were whitened with a photoactivated gel, and 30 in the placebo group. The Smile Esthetics-Related Quality of Life and Multidimensional Perfectionism Scale questionnaires were administered to all participants...
April 6, 2018: International Journal of Prosthodontics
https://www.readbyqxmd.com/read/29622800/british-orthodontic-society-s-initiative-on-orthodontic-retention-a-gdp-s-perspective
#20
P V Mc Crory
The British Orthodontic Society (BOS) recently published a number of news articles aimed at drawing attention to its 'Hold that Smile' campaign which promotes lifelong retainer wear. The BOS's stated intention is to 'generate a viral #HoldthatSmile campaign in order to build awareness of its message that retainers are for life'. The campaign also seeks to recruit the support of GDPs and DCPs, including nurses, in motivating patients to wear retainers for life. It suggests that orthodontists and GDPs need to work collaboratively and suggests that dentists would need to check patients are taking care of their retainers over the long term...
April 6, 2018: British Dental Journal
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