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https://www.readbyqxmd.com/read/29453204/circulating-mirna-profiles-associated-with-hyperglycemia-in-patients-with-type-1-diabetes-mellitus
#1
Eiichiro Satake, Marcus G Pezzolesi, Zaipul I Md Dom, Adam M Smiles, Monika A Niewczas, Andrzej S Krolewski
We investigated plasma microRNA (miRNA) profiles associated with variation of hyperglycemia, measured as hemoglobin A 1c (HbA 1c ), in two panels of patients with type 1 diabetes (T1D). Using the HTG Molecular Diagnostics EdgeSeq platform, 2,083 miRNAs were measured in plasma from 71 patients included in a screening panel. Quantitative real-time polymerase chain reaction was used to measure the candidate miRNAs in plasma from 95 patients included in an independent replication panel. We found 10 miRNAs replicated in both panels and four with high statistical significance...
February 16, 2018: Diabetes
https://www.readbyqxmd.com/read/29441524/the-economy-of-smiles-affect-labour-and-the-contemporary-deserving-poor
#2
Jessica Gerrard
This paper examines the affective dimensions of new forms of informal entrepreneurial work carried out in spaces of unemployment. Situating the analysis within contemporary scholarship on deservingness and on affect and labour, I shed light on the forms of entrepreneurial labour that rely upon affect-driven economies of exchange underpinned by moral judgements of deservingness, value and worth. In particular, this paper draws on a multi-city (Melbourne, London, San Francisco) study of homeless street press sellers (The Big Issue and Street Sheet) to explore the ways in which contemporary practices of charity and care are carried out through individualized market-place exchanges...
February 14, 2018: British Journal of Sociology
https://www.readbyqxmd.com/read/29439565/quasi-smiles-based-nano-qsar-model-to-predict-the-cytotoxicity-of-multi-walled-carbon-nanotubes-to-human-lung-cells
#3
Tung Xuan Trinh, Jang-Sik Choi, Hyunpyo Jeon, Hyung-Gi Byun, Tae Hyun Yoon, Jongwoon Kim
Quantitative structure-activity relationship (QSAR) models for nanomaterials (nano-QSAR) were developed to predict the cytotoxicity of 20 different types of multi-walled carbon nanotubes (MWCNTs) to human lung cells by using quasi-SMILES. The optimal descriptors, recorded as quasi-SMILES, were encoded to represent the physicochemical properties and experimental conditions for the MWCNTs from 276 data records collected from previously published studies. The qua-si-SMILES used to build the optimal descriptors were (i) diameter, (ii) length, (iii) surface area, (iv) in vitro toxicity assay, (v) cell line, (vi) exposure time, and (vii) dose...
February 14, 2018: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/29432422/topicalpdb-a-database-of-topically-delivered-peptides
#4
Deepika Mathur, Ayesha Mehta, Priyanka Firmal, Gursimran Bedi, Charu Sood, Ankur Gautam, Gajendra P S Raghava
TopicalPdb (http://crdd.osdd.net/raghava/topicalpdb/) is a repository of experimentally verified topically delivered peptides. Data was manually collected from research articles. The current release of TopicalPdb consists of 657 entries, which includes peptides delivered through the skin (462 entries), eye (173 entries), and nose (22 entries). Each entry provides comprehensive information related to these peptides like the source of origin, nature of peptide, length, N- and C-terminal modifications, mechanism of penetration, type of assays, cargo and biological properties of peptides, etc...
2018: PloS One
https://www.readbyqxmd.com/read/29432106/a-feasibility-study-of-autism-behavioral-markers-in-spontaneous-facial-visual-and-hand-movement-response-data
#5
Manar D Samad, Norou Diawara, Jonna L Bobzien, John W Harrington, Megan A Witherow, Khan M Iftekharuddin
Autism spectrum disorder (ASD) is a neurodevelopmental disability with atypical traits in behavioral and physiological responses. These atypical traits in individuals with ASD may be too subtle and subjective to measure visually using tedious methods of scoring. Alternatively, the use of intrusive sensors in the measurement of psychophysical responses in individuals with ASD may likely cause inhibition and bias. This paper proposes a novel experimental protocol for non-intrusive sensing and analysis of facial expression, visual scanning, and eye-hand coordination to investigate behavioral markers for ASD...
February 2018: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/29429287/-observational-study-on-the-impact-of-corneal-power-on-refractive-status-of-patients-after-small-incision-lenticule-extraction-surgery
#6
T Liu, T Yu, J Pan, Y C Zou, L N Liu, Q X Kan, J Bai
Objective: To observe the change of refractive status and possible influencing factors for patients with different corneal power who underwent small incision lenticule extraction (SMILE) surgery. Methods: Prospective cohort study was performed for patients who underwent small incision lenticule extraction (SMILE) surgery at Daping Hospital and Research Institute of Surgery of Third Military Medical University between January and August 2016. The patients were divided into 3 groups according to their corneal power: low curvature group (K(1)≤41...
January 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29429284/-clinical-observation-on-corneal-transparency-after-small-incision-lenticule-extraction-surgery
#7
L Zhang, Y Wang, T Cui, W Zhao, W B Cheng
Objective: To evaluate the changes of corneal transparency over the 1-year period after small incision lenticule extraction (SMILE) according to corneal Scheimpflug densitometry. Methods: Prospective cohort study. Fifty-five patients (100 eyes) with myopia (19 male and 36 female, aged 18 to 39 years with average of 24) who underwent SMILE and regular follow-up for at least 1 year at Tianjin Eye Hospital were enrolled. Examinations took place before SMILE and postoperatively at 1 day, 1 week, and 1, 3, 6, and 12 months...
January 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29429283/-advantages-and-disadvantages-of-femtosecond-laser-assisted-lasik-and-smile
#8
F J Zhang, M S Sun
With the development of excimer laser and femtosecond laser equipment, application of diversified and customized surgical decision in modern corneal refractive surgery has been an inevitable trend. However, how to make a personalized decision with an accurate surgical design to achieve better visual quality becomes the main focus in clinical applications. Small-incision lenticule extraction (SMILE) and femtosecond assisted laser in situ keratomileusis (FS-LASIK) have been commonly acknowledged as the mainstream of corneal refractive surgery for ametropia correction nowadays...
January 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29429282/-problems-and-challenges-in-the-development-of-corneal-refractive-surgery
#9
Y Wang, J Li
Corneal refractive surgery, as one of the common visual correction methods, has been increasingly accepted in China. There are a large number of people in China who undergo the corneal refractive surgery due to the high incidence of myopia in the country. It is essential that the safest and most effective surgery should be used to correct refractive errors in the cases involved with relatively normal eyes and corneas. In recent years, corneal refractive surgery has been rapidly developing with new technologies and techniques emerging all the time, such as SMILE (small incision lenticule extraction) surgery, which has been extensively applied in China since five years ago when it was approved by FDA...
January 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29425387/intraoperative-patient-experience-and-postoperative-visual-quality-after-smile-and-lasik-in-a-randomized-paired-eye-controlled-study
#10
Iben B Damgaard, Marcus Ang, Mohamed Farook, Hla M Htoon, Jodhbir S Mehta
PURPOSE: To compare intraoperative and postoperative subjective patient experience after small incision lenticule extraction (SMILE) and femtosecond laser-assisted LASIK. METHODS: In a prospective, randomized, paired-eye, single-masked clinical trial at Singapore National Eye Centre, 70 patients were randomly treated with SMILE and LASIK in each eye. The intraoperative questionnaire was completed immediately after surgery and included light perception and levels of anxiety, fear, and discomfort...
February 1, 2018: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/29425380/the-distinguishing-motor-features-of-cataplexy-a-study-from-video-recorded-attacks
#11
Fabio Pizza, Elena Antelmi, Stefano Vandi, Stefano Meletti, Roberto Erro, Christian R Baumann, Kailash P Bhatia, Yves Dauvilliers, Mark J Edwards, Alex Iranzo, Sebastiaan Overeem, Michele Tinazzi, Rocco Liguori, Giuseppe Plazzi
Objectives: To describe the motor pattern of cataplexy and to determine its phenomenological differences from pseudocataplexy in the differential diagnosis of episodic falls. Methods: We selected 30 video recorded cataplexy and 21 pseudocataplexy attacks in 17 and 10 patients evaluated for suspected narcolepsy and with final diagnosis of narcolepsy type 1 and conversion disorder respectively, together with self-reported attacks features, and asked expert neurologists to blindly evaluate the motor features of the attacks...
February 7, 2018: Sleep
https://www.readbyqxmd.com/read/29423522/societal-identification-of-facial-paralysis-and-paralysis-location
#12
Peiyi Su, Lisa E Ishii, Jason Nellis, Jacob Dey, Kristin L Bater, Patrick J Byrne, Kofi D O Boahene, Masaru Ishii
Importance: When able to identify facial paralysis, members of society regard individuals with facial paralysis differently. They perceive a decrease in attractiveness, more negative affect, and lower quality of life. However, the ability of lay people in society to accurately identify the presence of facial paralysis has not yet been defined. Objective: To determine societal members' ability to (1) identify paralysis in varying degrees of paralysis severity and (2) localize the defect on the face...
February 8, 2018: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/29422593/book-review-the-smile-stealers
#13
Anisha Gupta
No abstract text is available yet for this article.
February 9, 2018: British Dental Journal
https://www.readbyqxmd.com/read/29422585/saving-smiles-trauma-toolkit-launched
#14
James Darcey
No abstract text is available yet for this article.
February 9, 2018: British Dental Journal
https://www.readbyqxmd.com/read/29420377/modified-lengthening-temporalis-myoplasty-involving-an-extended-lazy-s-incision-to-avoid-facial-scar-formation
#15
Tomito Oji, Akiteru Hayashi, Akihiro Ogino, Kiyoshi Onishi
BACKGROUND: Lengthening temporalis myoplasty is a faster and less invasive alternative to free muscle transfer for smile reconstruction. However, it requires a nasolabial fold incision, which leaves a midfacial scar. Based on esthetic considerations, a modified approach, involving an extended lazy-S (parotidectomy) incision instead of a nasolabial fold incision, was developed. METHODS: A cadaveric study involving 10 hemifaces was conducted. From February 2013 to March 2016, the modified lengthening temporalis myoplasty procedure was employed in 10 patients...
February 7, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29417573/smile-aesthetics-satisfaction-scale-development-and-validation-of-a-new-brief-five-item-measure-of-satisfaction-with-smile-aesthetics-in-adults-and-the-elderly
#16
Vlatka Lajnert, Daniela Kovacevic Pavicic, Andrej Pavlic, Alessandra Pokrajac-Bulian, Stjepan Spalj
OBJECTIVE: To create and validate a brief questionnaire designed for the assessment of satisfaction with smile aesthetics and to test its efficiency as a patient-centred outcome measure of aesthetic interventions in dentistry. MATERIALS AND METHODS: A team of three specialists - two from prosthodontics and one psychologist - used a self-evaluation scale consisting of five elements in order to rate self-perceived smile aesthetics. A total of 671 subjects (63% female), 18-86 years of age, were included in the investigation...
February 7, 2018: International Dental Journal
https://www.readbyqxmd.com/read/29416315/comparison-of-corneal-biomechanics-after-myopic-small-incision-lenticule-extraction-compared-to-lasik-an-ex-vivo-study
#17
Anastasios John Kanellopoulos
Purpose: To investigate ex vivo potentially different corneal biomechanical properties after small-incision lenticule extraction (SMILE) versus LASIK for myopic correction. Methods: Thirty human donor corneas were subjected to either myopic SMILE or femtosecond laser-assisted LASIK. Donor corneas were assigned to six investigative groups: Group A, -3.00 D (diopters) SMILE; Group B, -8.00 D SMILE; Group C, -3.00 D LASIK; and Group D, -8.00 D LASIK. Additionally, two control groups were formed: Group E, SMILE and Group F, LASIK...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29415559/development-of-a-brief-version-of-the-autism-detection-in-early-childhood
#18
Yong-Hwee Nah, Robyn L Young, Neil Brewer
While autism spectrum disorder screening tools provide a useful resource for practitioners, the reality is they are underused. The justifications often provided include the time required for administration and the training involved. A brief tool with good psychometric properties that require minimal training is required. This study examined the development and the psychometric properties of a brief version of the Autism Detection in Early Childhood. The data showed the potential of the brief version of Autism Detection in Early Childhood for screening children age 12-36 months...
February 1, 2018: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/29410266/visual-sensorimotor-and-cognitive-routes-to-understanding-others-enjoyment-an-individual-differences-rtms-approach-to-empathic-accuracy
#19
Riccardo Paracampo, Martina Pirruccio, Marco Costa, Sara Borgomaneri, Alessio Avenanti
Functional imaging studies suggest that accurate understanding of others' emotional feelings (i.e., empathic accuracy, EA) recruits high-order visual, sensorimotor and mentalizing brain networks. However, the behavioral relevance of these findings is unclear. To fill in this gap, we used repetitive transcranial magnetic stimulation (rTMS) to interfere with the right superior temporal sulcus (STS), inferior frontal gyrus (IFG) and temporoparietal junction (TPJ) during an EA task requiring participants to infer the enjoyment felt by a social target while smiling/laughing...
February 1, 2018: Neuropsychologia
https://www.readbyqxmd.com/read/29408954/args-oap-v2-0-with-an-expanded-sarg-database-and-hidden-markov-models-for-enhancement-characterization-and-quantification-of-antibiotic-resistance-genes-in-environmental-metagenomes
#20
Xiaole Yin, Xiao-Tao Jiang, Benli Chai, Liguan Li, Ying Yang, James R Cole, James M Tiedje, Tong Zhang
Motivation: Much global attention has been paid to antibiotic resistance in monitoring its emergence, accumulation and dissemination. For rapid characterization and quantification of antibiotic resistance genes (ARGs) in metagenomic datasets, an online analysis pipeline, ARGs-OAP has been developed consisting of a database termed Structured Antibiotic Resistance Genes (the SARG) with a hierarchical structure (ARGs type-subtype-reference sequence). Results: The new release of the database, termed SARG version 2...
February 2, 2018: Bioinformatics
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