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Autoimmune piastrinopenia

G Bragagni, G Bianconcini, R Brogna, G Zoli
BACKGROUND: Pseudothrombocytopenia (PTCP) is characterized by in vitro EDTA-, pH-, temperature- and time-dependent clumping which gives rise to spurious piastrinopenia at platelet count in automatized analyzers. It is caused by serum immunoglobulins recognizing some cryptoantigens on the platelet surface membrane. Aim of this study was to evaluate the prevalence of PTCP in a series of patients and its clinical significance. METHODS: From all the inpatients, in Internal Medicine Division, during 29 months, we have considered as PTCP the thrombocytopenias persistent in EDTA and contemporaneously, missing with ACD at the automatized counter, after microscopic examination...
February 2001: Minerva Medica
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