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https://www.readbyqxmd.com/read/29447320/a-pilot-study-on-the-efficacy-of-a-treatment-algorithm-to-detoxify-dental-implant-surfaces-affected-by-peri-implantitis
#1
Paul S Rosen, Maha Qari, Stuart J Froum, Serge Dibart, L Lee Chou
This in vitro pilot study was performed to determine whether a treatment algorithm including mechanical debridement, followed by air powder abrasion with glycine, followed by citric acid conditioning with vigorous flushing of the surface with sterile water after each step, is capable of decontaminating an infected implant surface. A total of 14 dental implants that were deemed hopeless due to advanced peri-implantitis were extracted. Of these, 6 implants served as tests and had their exposed surfaces treated with the decontamination protocol, 6 served as untreated controls, and 2 were mechanically treated only, followed by rubbing the surface with sterile saline...
March 2018: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/29447315/failed-blade-implant-after-25-years-in-function-case-description-and-histologic-analysis
#2
Davide Farronato, Davide Fumagalli, Farah Asa'ad, Pietro M Pasini, Francesco Mangano, Giulio Rasperini
This report describes a failed blade implant after 25 years in function in the left maxilla and the results of histologic analysis of peri-implant tissues. The blade was retrieved, and histologic findings revealed that it was not osseointegrated despite being successfully in function for so many years. The long-term function of blade implants without osseointegration can be attributed to biotolerance exhibited by the implant rather than actual osseointegration.
March 2018: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/29447312/the-bone-core-technique-for-the-augmentation-of-limited-bony-defects-five-year-prospective-study-with-a-new-minimally-invasive-technique
#3
Fouad Khoury, Romain Doliveux
The aim of this study was to evaluate a new minimally invasive surgical technique for the reconstruction of critical-size bony defect with local harvested bone core with simultaneous implant placement. In a prospective study, 186 consecutively treated patients were included and controlled clinically and radiologically for at least 5 years postoperative. Every patient presented a bony defect affecting the buccal, lingual, or palatal wall. In all cases, the alveolar crest was wide enough to allow implant placement inside the bony contours...
March 2018: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/29446171/retrospective-analysis-of-intrathecal-drug-delivery-outcomes-efficacy-and-risk-for-cancer-related-pain-at-a-high-volume-academic-medical-center
#4
Dawood Sayed, Forrest Monroe, Walter N Orr, Milind Phadnis, Talal W Khan, Edward Braun, Smith Manion, Andrea Nicol
OBJECTIVES: Cancer pain is common and difficult to treat, as conservative medical management fails in approximately 20% of patients for reasons such as intolerable side-effects or failure to control pain. Intrathecal drug delivery systems (IDDS), while underutilized, can be effective tools to treat intractable cancer pain. This study aims to determine the degree of pain relief, efficacy, and safety of patients who underwent IDDS implantation at a multidisciplinary pain clinic. MATERIALS AND METHODS: A retrospective review was conducted of patients with an intrathecal pain pump implanted for malignant pain...
February 14, 2018: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29446161/advancements-and-challenges-in-multidomain-multicargo-delivery-vehicles
#5
REVIEW
Eugenia Pugliese, João Q Coentro, Dimitrios I Zeugolis
Reparative and regenerative processes are well-orchestrated temporal and spatial events that are governed by multiple cells, molecules, signaling pathways, and interactions thereof. Yet again, currently available implantable devices fail largely to recapitulate nature's complexity and sophistication in this regard. Herein, success stories and challenges in the field of layer-by-layer, composite, self-assembly, and core-shell technologies are discussed for the development of multidomain/multicargo delivery vehicles...
February 15, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29445060/clinical-usefulness-of-wearable-cardioverter-defibrillator-wcd-and-current-understanding-of-its-clinical-indication-in-japan
#6
Shinichi Niwano, Yukio Sekiguchi, Yosuke Ishii, Yuki Iwasaki, Ritsushi Kato, Hideo Okamura, Masahiko Takagi, Takashi Kurita, Takashi Nitta
Prevention of sudden cardiac death (SCD) has become an important issue in today's cardiovascular field, together with various developments in secondary prevention of basic cardiac diseases. The importance of the implantable cardioverter defibrillator (ICD) is now widely accepted because it has exhibited significant improvement in patients' prognoses in ischemic and non-ischemic cardiovascular diseases. However, there is an unignorable gap between the ICD indication in the guidelines and real-world high-risk patients for SCD, especially in the acute recovery phase of cardiac injury...
February 14, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29443081/recombinant-collagen-i-peptide-microcarriers-for-cell-expansion-and-their-potential-use-as-cell-delivery-system-in-a-bioreactor-model
#7
Melva Suarez Muñoz, Davide Confalonieri, Heike Walles, Elisabeth M W M van Dongen, Gudrun Dandekar
Tissue engineering is a promising field, focused on developing solutions for the increasing demand on tissues and organs regarding transplantation purposes. The process to generate such tissues is complex, and includes an appropriate combination of specific cell types, scaffolds, and physical or biochemical stimuli to guide cell growth and differentiation. Microcarriers represent an appealing tool to expand cells in a three-dimensional (3D) microenvironment, since they provide higher surface-to volume ratios and mimic more closely the in vivo situation compared to traditional two-dimensional methods...
February 7, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29442627/studies-on-mechanical-biocompatibility-and-antibacterial-activity-of-plasma-sprayed-nano-micron-ceramic-bilayered-coatings-on-ti-6al-4v-alloy-for-biomedical-application
#8
Suganthan Veerachamy, Pearlin Hameed, Dwaipayan Sen, Sitaram Dash, Geetha Manivasagam
Ceramic oxides such as alumina and zirconia are used to fabricate dental and orthopedic implants. However, their usage is limited as they fail due to low fracture toughness. To overcome this issue, ceramic coatings on metallic implants is attempted to have a combined effect of ceramics and metallic materials. This paper reports on the microstructure, phase analysis, mechanical properties, osseointegration and antibacterial activity of three different wear-resistant coatings developed on Ti-6Al-4V alloy which is used widely as orthopedic and dental implants...
July 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29440740/boston-keratoprosthesis-type-1-outcomes-of-the-first-38-cases-performed-at-moorfields-eye-hospital
#9
Chameen Samarawickrama, Nicholas Strouthidis, Mark R Wilkins
PURPOSE: To evaluate outcomes of Boston keratoprosthesis type 1 (K-Pro) surgery in a cohort of high-risk patients at Moorfields Eye Hospital. Our patients were referred to us at the end-point of their ocular disease. METHODS: A retrospective review of all K-Pro surgery performed between March 2011 and July 2015 with a minimum follow-up of 12 months. RESULTS: 39 eyes of 38 patients were included. Mean follow-up was 28.4 months (range: 12-56)...
February 14, 2018: Eye
https://www.readbyqxmd.com/read/29437678/multidisciplinary-surgical-team-approach-for-excision-of-squamous-cell-carcinoma-overlying-pacemaker-site
#10
Neil Bodagh, Elena Pappa, Fahad Farooqi
We report an unusual case of an elderly man presenting with a fast-growing large malignant tumour involving the skin overlying his permanent pacemaker site. The fast-growing cutaneous squamous cell carcinoma appeared 2 years after pacemaker implantation. Joint specialist input was required to tackle this complex problem as a wide surgical excision would expose the pacemaker generator risking device infection particularly if the skin graft reconstruction failed. Having established that the patient had minimal pacing needs, it was determined through expedited multidisciplinary discussion that the best option was excision of the lesion with skin grafting of the defect by maxillofacial surgical team and pacemaker generator removal by a cardiologist in a joint surgical procedure...
February 6, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29427125/survival-complications-and-functional-outcomes-of-cemented-megaprostheses-for-high-grade-osteosarcoma-around-the-knee
#11
Chunlin Zhang, Jianping Hu, Kunpeng Zhu, Tao Cai, Xiaolong Ma
PURPOSE: We initiated a retrospective study on the long-term survival of cemented endoprostheses for bone tumours around the knee to answer the following questions: (1) What was the survival of these patients? (2) What was the overall survival of cemented prostheses around the knee? (3) What types of failures were observed in these reconstructions? (4) Did the survival and complications vary according to the site of the implant? (5) What was the functional result after cemented prosthesis replacement around the knee? METHODS: From January 2006 to December 2013, 108 consecutive patients with an average age of 25 years, who had mature bone development as evidenced by imaging examinations, underwent 108 cemented endoprosthetic knee replacements for osteosarcoma resection...
February 9, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29426604/damage-in-a-distal-radius-fracture-model-treated-with-locked-volar-plating-after-simulated-postoperative-loading
#12
Christina Salas, Justin A Brantley, James Clark, Mahmoud Reda Taha, Deana M Mercer, Orrin B Myers
PURPOSE: "Damage" is an engineering term defining a period between a state of material perfection and the onset of crack initiation. Clinically, it is a loss of fixation due to microstructural breakdown, indirectly measured as a reduction of stiffness of the bone-implant construct, normalized by the cross-sectional area and length of the bone. The purpose of this study was to characterize damage in a cadaver model of extra-articular distal radius fracture with dorsal comminution treated using 2-column volar distal radius plates...
February 6, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29424019/altering-spacer-material-affects-bone-regeneration-in-the-masquelet-technique-in-a-rat-femoral-defect
#13
Sarah McBride-Gagyi, Zacharie Toth, Daniel Kim, Victoria Ip, Emily Evans, J Tracy Watson, Daemeon Nicolaou
The Masquelet technique depends on pre-development of a foreign-body membrane to support bone regeneration with grafts over three times larger than the traditional maximum. To date, the procedure has always used spacers made of bone cement, which is the polymer polymethyl methacrylate (PMMA), to induce the foreign-body membrane. This study sought to compare (i) morphology, factor expression, and cellularity in membranes formed by PMMA, titanium, and polyvinyl alcohol sponge (PVA) spacers in the Masquelet milieu and (ii) subsequent bone regeneration in the same groups...
February 9, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29420673/influence-of-different-screw-torque-levels-on-the-biomechanical-behavior-of-tapered-prosthetic-abutments
#14
Paulo Eduardo Herbst, Eduardo Bortolas de Carvalho, Rafael C Salatti, Laiz Valgas, Rodrigo Tiossi
PURPOSE: To study the force used for tightening tapered one-piece prosthetic abutments and their influence on the removal torque value and stress level of the prosthetic abutment after cyclic loading. MATERIALS AND METHODS: Fourteen implants and prosthetic abutments were divided into two groups (n = 7): G1, 20 Ncm; and G2, 32 Ncm (manufacturer recommended). A 20-mm T-shaped horizontal bar was adapted to the abutments. A 12-Hz cyclic loading was applied to the specimens in an electrodynamic testing system with the maximum number of cycles set to 106...
February 8, 2018: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/29411881/green-synthesized-silver-nanoparticles-demonstrating-enhanced-in-vitro-and-in-vivo-antibiofilm-activity-against-candida-spp
#15
Subramanian Muthamil, Vivekanandham Amsa Devi, Boopathi Balasubramaniam, Krishnaswamy Balamurugan, Shunmugiah Karutha Pandian
Candida species are opportunistic fungal pathogens, which are known for their biofilm associated infections on implanted medical devices in clinical settings. Broad spectrum usage of azole groups and other antifungal agents leads to the occurrence of drug resistance among Candida species. Most of the antifungal agents have failed to treat the biofilm mediated Candida infections. In the present study, silver nanoparticles (AgNPs) were synthesized using Dodonaea viscosa and Hyptis suoveolens methanolic leaf extracts and characterized by ultraviolet-visible absorption spectroscopy, X-ray diffraction analysis, Fourier transform infrared spectroscopy and Scanning electron microscopy, Dynamic light scattering, and Zeta potential analysis...
February 7, 2018: Journal of Basic Microbiology
https://www.readbyqxmd.com/read/29410193/inflammation-associated-cytokines-igfbp1-and-rantes-impair-the-megakaryocytic-potential-of-hscs-in-pt-patients-after-allo-hsct
#16
Cuicui Liu, Yiqing Yang, Dan Wu, Wenxia Zhang, Hongtao Wang, Pei Su, Jianfeng Yao, Chen Liang, Sizhou Feng, Mingzhe Han, Fuxu Wang, Erlie Jiang, Jiaxi Zhou
Prolonged isolated thrombocytopenia (PT) is a severe complication in patients after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Whether the megakaryoctic potential of hematopoietic stem cells (HSCs) in bone marrow is intact and what factors drive the pathological process of PT remain elusive. A retrospective study in patients (n=285) receiving HSC transplantation revealed that the occurrence of PT was approximately 8% and the number of platelets and megakaryocytes in PT patients is much lower compared to the control...
January 31, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29408716/scanning-fiber-endoscope-improves-detection-of-5-ala-induced-protoporphyrin-ix-fluorescence-at-the-boundary-of-infiltrative-glioma
#17
Evgenii Belykh, Eric J Miller, Danying Hu, Nikolay L Martirosyan, Eric C Woolf, Adrienne C Scheck, Vadim A Byvaltsev, Peter Nakaji, Leonard Y Nelson, Eric J Seibel, Mark C Preul
OBJECTIVE: Fluorescence-guided surgery with protoporphyrin IX (PpIX) as a photodiagnostic marker is gaining acceptance for resection of malignant gliomas. Current wide-field imaging technologies do not have sufficient sensitivity to detect low PpIX concentrations. We evaluated a scanning fiber endoscope (SFE) for detection of PpIX fluorescence in gliomas and compared it with an operating microscope (OPMI) equipped with fluorescence module and a benchtop confocal laser scanning microscope (CLSM)...
January 31, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29407072/poor-outcomes-of-fusion-with-trabecular-metal-implants-after-failed-total-ankle-replacement-early-results-in-11-patients
#18
S Aubret, L Merlini, M Fessy, J L Besse
INTRODUCTION: One of the reasons for revision of total ankle replacement (TAR) implants is loosening due to subchondral cysts. Reconstruction and fusion of the ankle is often the first choice for revision procedures due to the large bone defects, which are typically filled with autograft and/or allograft. Filling the defect with a trabecular metal tantalum implant is a potential alternative given the biomechanical properties of this component. HYPOTHESIS: Using tantalum as a spacer provides primary stability and contributes to fusion of the ankle joint after removal of failed TAR implants...
January 30, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29406339/implications-of-introducing-new-technology-comparative-survivorship-modeling-of-metal-on-metal-hip-replacements-and-contemporary-alternatives-in-the-national-joint-registry
#19
Linda P Hunt, Michael R Whitehouse, Andrew Beswick, Martyn L Porter, Peter Howard, Ashley W Blom
BACKGROUND: New medical technologies are often used widely without adequate supporting data, a practice that can lead to widespread catastrophic failure such as occurred with metal-on-metal (MoM) hip replacements. We determined both how revision rates would have differed if, instead of receiving MoM hip replacements, patients had received existing alternatives and the subsequent cumulative re-revision rates of the patients who did receive MoM hip replacements compared with alternatives...
February 7, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29402916/transcriptomic-changes-in-the-pre-implantation-uterus-highlight-histotrophic-nutrition-of-the-developing-marsupial-embryo
#20
Camilla M Whittington, Denis O'Meally, Melanie K Laird, Katherine Belov, Michael B Thompson, Bronwyn M McAllan
Early pregnancy is a critical time for successful reproduction; up to half of human pregnancies fail before the development of the definitive chorioallantoic placenta. Unlike the situation in eutherian mammals, marsupial pregnancy is characterised by a long pre-implantation period prior to the development of the short-lived placenta, making them ideal models for study of the uterine environment promoting embryonic survival pre-implantation. Here we present a transcriptomic study of pre-implantation marsupial pregnancy, and identify differentially expressed genes in the Sminthopsis crassicaudata uterus involved in metabolism and biosynthesis, transport, immunity, tissue remodelling, and uterine receptivity...
February 5, 2018: Scientific Reports
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