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https://www.readbyqxmd.com/read/29312750/mitral-valve-prolapse-an-underestimated-cause-of-sudden-cardiac-death-a-current-review-of-the-literature
#1
REVIEW
Michael Spartalis, Eleni Tzatzaki, Eleftherios Spartalis, Antonios Athanasiou, Demetrios Moris, Christos Damaskos, Nikolaos Garmpis, Vassilis Voudris
Mitral valve prolapse (MVP) is a common valve abnormality in general population. Despite the general belief of a benign disorder, several articles since the 1980s report sudden cardiac death (SCD) in MVP patients, with a substantial percentage of asymptomatic young individuals. The problem is to detect those patients at increased risk and implement methods that are suitable to prevent cardiac arrest. This review investigates the correlation between MVP and SCD, the understanding of the pathophysiology, the strategies for detecting those at risk and treatment options...
December 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29303333/strong-constraints-on-cosmological-gravity-from-gw170817-and-grb-170817a
#2
T Baker, E Bellini, P G Ferreira, M Lagos, J Noller, I Sawicki
The detection of an electromagnetic counterpart (GRB 170817A) to the gravitational-wave signal (GW170817) from the merger of two neutron stars opens a completely new arena for testing theories of gravity. We show that this measurement allows us to place stringent constraints on general scalar-tensor and vector-tensor theories, while allowing us to place an independent bound on the graviton mass in bimetric theories of gravity. These constraints severely reduce the viable range of cosmological models that have been proposed as alternatives to general relativistic cosmology...
December 22, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29224732/handheld-isothermal-amplification-and-electrochemical-detection-of-dna-in-resource-limited-settings
#3
Maria-Nefeli Tsaloglou, Alex Nemiroski, Gulden Camci-Unal, Dionysios C Christodouleas, Lara P Murray, John T Connelly, George M Whitesides
This paper demonstrates a new method for electrochemical detection of specific sequences of DNA present in trace amounts in serum or blood. This method is designed for use at the point-of-care (particularly in resource-limited settings). By combining recombinase polymerase amplification (RPA)- an isothermal alternative to the polymerase chain reaction - with an electroactive mediator, this electrochemical methodology enables accurate detection of DNA in the field using a low-cost, portable electrochemical analyzer (specifically designed for this type of analysis)...
December 7, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/29211720/blazar-spectral-variability-as-explained-by-a-twisted-inhomogeneous-jet
#4
C M Raiteri, M Villata, J A Acosta-Pulido, I Agudo, A A Arkharov, R Bachev, G V Baida, E Benítez, G A Borman, W Boschin, V Bozhilov, M S Butuzova, P Calcidese, M I Carnerero, D Carosati, C Casadio, N Castro-Segura, W-P Chen, G Damljanovic, F D'Ammando, A Di Paola, J Echevarría, N V Efimova, Sh A Ehgamberdiev, C Espinosa, A Fuentes, A Giunta, J L Gómez, T S Grishina, M A Gurwell, D Hiriart, H Jermak, B Jordan, S G Jorstad, M Joshi, E N Kopatskaya, K Kuratov, O M Kurtanidze, S O Kurtanidze, A Lähteenmäki, V M Larionov, E G Larionova, L V Larionova, C Lázaro, C S Lin, M P Malmrose, A P Marscher, K Matsumoto, B McBreen, R Michel, B Mihov, M Minev, D O Mirzaqulov, A A Mokrushina, S N Molina, J W Moody, D A Morozova, S V Nazarov, M G Nikolashvili, J M Ohlert, D N Okhmat, E Ovcharov, F Pinna, T A Polakis, C Protasio, T Pursimo, F J Redondo-Lorenzo, N Rizzi, G Rodriguez-Coira, K Sadakane, A C Sadun, M R Samal, S S Savchenko, E Semkov, B A Skiff, L Slavcheva-Mihova, P S Smith, I A Steele, A Strigachev, J Tammi, C Thum, M Tornikoski, Yu V Troitskaya, I S Troitsky, A A Vasilyev, O Vince
Blazars are active galactic nuclei, which are powerful sources of radiation whose central engine is located in the core of the host galaxy. Blazar emission is dominated by non-thermal radiation from a jet that moves relativistically towards us, and therefore undergoes Doppler beaming. This beaming causes flux enhancement and contraction of the variability timescales, so that most blazars appear as luminous sources characterized by noticeable and fast changes in brightness at all frequencies. The mechanism that produces this unpredictable variability is under debate, but proposed mechanisms include injection, acceleration and cooling of particles, with possible intervention of shock waves or turbulence...
December 4, 2017: Nature
https://www.readbyqxmd.com/read/29211288/pre-sintered-y-tzp-sandblasting-effect-on-surface-roughness-phase-transformation-and-y-tzp-veneer-bond-strength
#5
Carla Müller Ramos-Tonello, Bruno Freitas Trevizo, Raphaela Farias Rodrigues, Ana Paula Rodrigues Magalhães, Adilson Yoshio Furuse, Paulo Noronha Lisboa-Filho, Americo Sheitiro Tabata, Ana Flávia Sanches Borges
OBJECTIVES.: Sandblasting is a common method to try to improve the Y-TZP/veneer bond strength of dental prostheses, however, it may put stress on zirconia surfaces and could accelerate the t→m phase transformation. Y-TZP sandblasting before sintering could be an alternative to improve surface roughness and bonding strength of veneering ceramic. The aim of this study was to analyze the effect of Y-TZP pre-sintering sandblasting on surface roughness, phase transformation, and the Y-TZP/veneer shear bond strength...
November 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/29197657/feasibility-of-extravascular-pacing-with-a-novel-substernal-electrode-configuration-the-substernal-pacing-acute-clinical-evaluation-study
#6
Darius P Sholevar, Stanley Tung, Vikas Kuriachan, Peter Leong-Sit, Henri Roukoz, Gregory Engel, Steven P Kutalek, Devender Akula, Amy E Thompson, Melissa G T Christie, Marina Ostanniy, Franck Molin
BACKGROUND: Subcutaneous implantable cardioverter-defibrillators provide an alternative to transvenous defibrillation but require higher shock outputs and offer no antitachycardia pacing. The Substernal Pacing Acute Clinical Evaluation (SPACE) study evaluated the feasibility of pacing from an extravascular substernal location. OBJECTIVES: The primary purpose of the SPACE study was to characterize pacing from the substernal space. Secondary objectives included evaluating extracardiac stimulation and recording electrograms...
December 2, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29120016/the-subcutaneous-implantable-cardioverter-defibrillator-in-daily-clinical-practice
#7
Tardu Özkartal, Alexander Breitenstein, Ardan M Saguner, Devdas T Inderbitzin, Markus Wilhelm, Stefano Benussi, Francesco Maisano, Thomas F Lüscher, Frank Ruschitzka, Jan Steffel
INTRODUCTION: In Switzerland, the first implantation of a subcutaneous implantable cardioverter-defibrillator (S-ICD) took place in November 2012. Up until the end of 2016, a total of 111 S-ICDs have been implanted. The aim of this study was to summarise the experience of a tertiary centre in Switzerland and to discuss the results in the context of international registries. METHODS: All patients in whom an S-ICD was implanted between November 2012 and the end of December 2016 at the University Heart Centre Zurich were included in this study...
November 9, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29114545/overcoming-resistance-to-braf-inhibitors
#8
REVIEW
Imanol Arozarena, Claudia Wellbrock
The discovery of activating mutations in the serine/threonine (S/T) kinase BRAF followed by a wave of follow-up research manifested that the MAPK-pathway plays a critical role in melanoma initiation and progression. BRAF and MEK inhibitors produce an unparalleled response rate in melanoma, but it is now clear that most responses are transient, and while some patients show long lasting responses the majority progress within 1 year. In accordance with the key role played by the MAPK-pathway in BRAF mutant melanomas, disease progression is mostly due to the appearance of drug-resistance mechanisms leading to restoration of MAPK-pathway activity...
October 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29096491/off-resonance-novel
#9
Sheetal K Jain, Guinevere Mathies, Robert G Griffin
Dynamic nuclear polarization (DNP) is theoretically able to enhance the signal in nuclear magnetic resonance (NMR) experiments by a factor γe/γn, where γ's are the gyromagnetic ratios of an electron and a nuclear spin. However, DNP enhancements currently achieved in high-field, high-resolution biomolecular magic-angle spinning NMR are well below this limit because the continuous-wave DNP mechanisms employed in these experiments scale as ω0(-n) where n ∼ 1-2. In pulsed DNP methods, such as nuclear orientation via electron spin-locking (NOVEL), the DNP efficiency is independent of the strength of the main magnetic field...
October 28, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29037423/unique-ecg-presentations-and-clinical-management-of-a-symptomatic-lqt2-female-carrying-a-novel-de-novo-kcnh2-mutation
#10
Chunlin Yin, Ping Zhang, Jing Yang, Li Zhang
A 26-year-old woman, 12 days in postpartum, developed recurrent syncope and cardiac arrest. Her ECG revealed QT-prolongation associated with LQT2-specific T-U wave patterns, T wave alternans, long QT-dependent torsade de pointes (TdP) and ventricular fibrillation (VF). She also had intermittent LBBB (80bpm) on alternate beats and RBBB at sinus tachycardia (113bpm). Family genotyping revealed a novel de novo missense mutation G604C of KCNH2. Propranolol slowed heart rate and further prolonged QT interval (610ms) that caused TdP recurrence...
August 17, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28978409/specific-indications-and-clinical-outcome-in-patients-with-subcutaneous-icd-a-nationwide-multicentre-registry
#11
Michael Sponder, Cesar Khazen, Wolfgang Dichtl, Lukas Fiedler, Deddo Mörtl, Alexander Teubl, Clemens Steinwender, Martin Martinek, Michael Nürnberg, Daniel Dalos, Johannes Kastner, Christoph Schukro
BACKGROUND: Subcutaneous implantable cardioverter-defibrillators (S-ICD) are an innovative and less invasive alternative to transvenous ICD (TV-ICD) in selected patients. We aimed to investigate the underlying diseases and the specific indications for implanting S-ICD in clinical practice, as well as the prevalence of shock delivery and complications. METHODS AND RESULTS: From December 2012, data of 236 patients (30,5% female; age 48,6±16,8years) were gathered from 12 centres in Austria...
October 1, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28949686/spin-current-generation-using-a-surface-acoustic-wave-generated-via-spin-rotation-coupling
#12
D Kobayashi, T Yoshikawa, M Matsuo, R Iguchi, S Maekawa, E Saitoh, Y Nozaki
We demonstrate the generation of alternating spin current (SC) via spin-rotation coupling (SRC) using a surface acoustic wave (SAW) in a Cu film. Ferromagnetic resonance caused by injecting SAWs was observed in a Ni-Fe film attached to a Cu film, with the resonance further found to be suppressed through the insertion of a SiO_{2} film into the interface. The intensity of the resonance depended on the angle between the wave vector of the SAW and the magnetization of the Ni-Fe film. This angular dependence is explicable in terms of the presence of spin transfer torque from a SC generated via SRC...
August 18, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28870114/alleviating-mechanical-allodynia-and-modulating-cellular-immunity-contribute-to-electroacupuncture-s-dual-effect-on-bone-cancer-pain
#13
Yi Liang, Jun-Ying Du, Jun-Fan Fang, Ruo-Yi Fang, Jie Zhou, Xiao-Mei Shao, Yong-Liang Jiang, Yi-Tian Chen, Jian-Qiao Fang
HYPOTHESIS: Electroacupuncture (EA) has been used as an alternative analgesic therapy for hundreds of years, yet its analgesic potency and therapeutic advantage against bone cancer pain (BCP) in comparison with morphine remains unclear. This study aimed to investigate the effects of EA on mechanical allodynia and cellular immunity of BCP rats, and to further explore the potential mechanism. METHODS: The BCP model was established by implanting Walker 256 mammary gland carcinoma cells into the left tibia of adult female Sprague-Dawley rats...
September 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/28854826/high-intensity-focused-ultrasound-in-the-treatment-of-breast-fibroadenomata-hifu-f-trial
#14
M C L Peek, M Ahmed, J Scudder, R Baker, P Charalampoudis, S E Pinder, M Douek
BACKGROUND: High-intensity focussed ultrasound (HIFU) is a non-invasive ablative technique utilising the application of high frequency ultrasound (US) pressure waves to cause tissue necrosis. This emerging technology is currently limited by prolonged treatment times. The aim of the HIFU-F trial was to perform circumferential HIFU treatment as a means of shortening treatment times. METHODS: A prospective trial was set up to treat 50 consecutive patients ≥18 years of age...
October 2, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28836911/infarction-or-pseudo-infarction
#15
Ross MacKenzie
An applicant with a history of paroxysmal atrial fibrillation is found to have QS waves in leads III and AVF suggestive of a prior inferior wall myocardial infarction. Using the relationship between Q wave and T wave vectors in the inferior leads, an alternative explanation is explored.
2017: Journal of Insurance Medicine
https://www.readbyqxmd.com/read/28802655/alternating-trifascicular-block-and-cardiac-memory
#16
Asaf Danon, Mohammed Shurrab
We describe a case of a 70year-old woman with effort dyspnea and alternating trifascicular conduction pattern, worsened with exercise to atrioventricular block (AV Block). The alternating conduction at rest resulted in marked T wave changes. We discuss the mechanism of T wave memory changes and the management of exercise-induced AV Block.
July 12, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28794084/mechanically-induced-ectopy-via-stretch-activated-cation-nonselective-channels-is-caused-by-local-tissue-deformation-and-results-in-ventricular-fibrillation-if-triggered-on-the-repolarization-wave-edge-commotio-cordis
#17
T Alexander Quinn, Honghua Jin, Peter Lee, Peter Kohl
BACKGROUND: External chest impacts (commotio cordis) can cause mechanically induced premature ventricular excitation (PVEM) and, rarely, ventricular fibrillation (VF). Because block of stretch-sensitive ATP-inactivated potassium channels curtailed VF occurrence in a porcine model of commotio cordis, VF has been suggested to arise from abnormal repolarization caused by stretch activation of potassium channels. Alternatively, VF could result from abnormal excitation by PVEM, overlapping with normal repolarization-related electric heterogeneity...
August 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28763347/ex-vivo-induction-of-multiple-myeloma-specific-immune-responses-by-monocyte-derived-dendritic-cells-following-stimulation-by-whole-tumor-antigen-of-autologous-myeloma-cells
#18
Spyridoula Vasileiou, Ioannis Baltadakis, Sosanna Delimpasi, Maria-Helena Karatza, Konstantinos Liapis, Maria Garofalaki, Eirini Tziotziou, Zoe Poulopoulou, Dimitri Karakasis, Nicholas Harhalakis
The introduction of novel agents has significantly expanded treatment options for multiple myeloma (MM), albeit long-term disease control cannot be achieved in the majority of patients. Vaccination with MM antigen-loaded dendritic cells (DCs) represents an alternative strategy that is currently being explored. The aim of this study was to assess the immunogenic potential of ex vivo-generated monocyte-derived DCs (moDCs), following stimulation with the whole-antigen array of autologous myeloma cells (AMC). MoDCs were loaded with antigens of myeloma cells by 2 different methods: phagocytosis of apoptotic bodies from γ-irradiated AMC, or transfection with AMC total RNA by square-wave electroporation...
July 31, 2017: Journal of Immunotherapy
https://www.readbyqxmd.com/read/28749343/a-potential-based-inverse-spectral-method-to-non-invasively-localize-discordant-distributions-of-alternans-on-the-heart-from-the-ecg
#19
Jaume Coll-Font, Burak Erem, Dana H Brooks
T-wave alternans (TWA), defined as the beat-to-beat alternation in amplitude of the T-waves, has been shown to be linked to ventricular fibrillation (VF). However, current TWA tests have high sensitivity but low specificity in determining who is at risk. To overcome this limitation, it might be helpful to determine the spatial distribution of any regions on the heart that alternate in opposite phase. Understanding these spatial distributions in relation to the regular activation of the heart could help explain the mechanism for the genesis of VF and thus disambiguate the low specificity of TWA...
July 26, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28737378/quantitative-mid-infrared-cavity-ringdown-detection-of-methyl-iodide-for-monitoring-applications
#20
Ibrahim Sadiek, Qiang Shi, Douglas W R Wallace, Gernot Friedrichs
Methyl iodide is a toxic halocarbon with diverse industrial and agricultural applications, and it is an important ocean-derived trace gas that contributes to the iodine burden of the atmosphere. Quantitative analysis of CH3I is mostly based on gas chromatography coupled with mass spectrometry or electron capture detection (GC-MS/ECD) as of yet, which often limits the ability to conduct in situ high-frequency monitoring studies. This work presents an alternative detection scheme based on mid-infrared continuous wave cavity ringdown spectroscopy (mid-IR cw-CRDS)...
August 4, 2017: Analytical Chemistry
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