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https://www.readbyqxmd.com/read/28317458/use-of-the-instantaneous-wave-free-ratio-or-fractional-flow-reserve-in-pci
#1
Justin E Davies, Sayan Sen, Hakim-Moulay Dehbi, Rasha Al-Lamee, Ricardo Petraco, Sukhjinder S Nijjer, Ravinay Bhindi, Sam J Lehman, Darren Walters, James Sapontis, Luc Janssens, Christiaan J Vrints, Ahmed Khashaba, Mika Laine, Eric Van Belle, Florian Krackhardt, Waldemar Bojara, Olaf Going, Tobias Härle, Ciro Indolfi, Giampaolo Niccoli, Flavo Ribichini, Nobuhiro Tanaka, Hiroyoshi Yokoi, Hiroaki Takashima, Yuetsu Kikuta, Andrejs Erglis, Hugo Vinhas, Pedro Canas Silva, Sérgio B Baptista, Ali Alghamdi, Farrel Hellig, Bon-Kwon Koo, Chang-Wook Nam, Eun-Seok Shin, Joon-Hyung Doh, Salvatore Brugaletta, Eduardo Alegria-Barrero, Martijin Meuwissen, Jan J Piek, Niels van Royen, Murat Sezer, Carlo Di Mario, Robert T Gerber, Iqbal S Malik, Andrew S P Sharp, Suneel Talwar, Kare Tang, Habib Samady, John Altman, Arnold H Seto, Jasvindar Singh, Allen Jeremias, Hitoshi Matsuo, Rajesh K Kharbanda, Manesh R Patel, Patrick Serruys, Javier Escaned
Background Coronary revascularization guided by fractional flow reserve (FFR) is associated with better patient outcomes after the procedure than revascularization guided by angiography alone. It is unknown whether the instantaneous wave-free ratio (iFR), an alternative measure that does not require the administration of adenosine, will offer benefits similar to those of FFR. Methods We randomly assigned 2492 patients with coronary artery disease, in a 1:1 ratio, to undergo either iFR-guided or FFR-guided coronary revascularization...
March 18, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28284506/sudden-cardiac-death-the-role-of-imaging
#2
Pieter van der Bijl, Victoria Delgado, Jeroen J Bax
Sudden cardiac death (SCD) is defined as "a non-traumatic, unexpected, fatal event occurring within one hour of the onset of symptoms in an apparently healthy subject", and it causes a fifth of all deaths worldwide. It often occurs in individuals not previously known with cardiac disease, which makes prevention challenging. The mechanism underlying SCD is thought to be a trigger (e.g. ischemia) acting upon a substrate (e.g. scar), causing a lethal arrhythmia. Primary prevention refers to patients at high risk of SCD and secondary prevention to those who have had an aborted episode of SCD...
March 6, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28248366/scattering-of-electromagnetic-waves-from-3d-multilayer-random-rough-surfaces-based-on-the-second-order-small-perturbation-method-energy-conservation-reflectivity-and-emissivity
#3
Mohammadreza Sanamzadeh, Leung Tsang, Joel T Johnson, Robert J Burkholder, Shurun Tan
A theoretical investigation of energy conservation, reflectivity, and emissivity in the scattering of electromagnetic waves from 3D multilayer media with random rough interfaces using the second-order small perturbation method (SPM2) is presented. The approach is based on the extinction theorem and develops integral equations for surface fields in the spectral domain. Using the SPM2, we calculate the scattered and transmitted coherent fields and incoherent fields. Reflected and transmitted powers are then found in the form of 2D integrations over wavenumber in the spectral domain...
March 1, 2017: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/28238117/membrane-permeabilization-of-pathogenic-yeast-in-alternating-sub-microsecond-electromagnetic-fields-in-combination-with-conventional-electroporation
#4
Vitalij Novickij, Eglė Lastauskienė, Jurgita Švedienė, Audrius Grainys, Gediminas Staigvila, Algimantas Paškevičius, Irutė Girkontaitė, Auksė Zinkevičienė, Svetlana Markovskaja, Jurij Novickij
Recently, a novel contactless treatment method based on high-power pulsed electromagnetic fields (PEMF) was proposed, which results in cell membrane permeabilization effects similar to electroporation. In this work, a new PEMF generator based on multi-stage Marx circuit topology, which is capable of delivering 3.3 T, 0.19 kV/cm sub-microsecond pulses was used to permeabilize pathogenic yeast Candida albicans separately and in combination with conventional square wave electroporation (8-17 kV/cm, 100 μs)...
February 25, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/28158032/composite-nd-yag-sic-bonding-laser-with-orthogonal-linear-polarization-output
#5
Yan Zhou, Jianqiu Xu, Yulong Tang
We report a multiple-gain-element Nd:YAG laser where the gain media (three pieces of slab crystal) are alternately bonded to two optical quality 4H-SiC wafers. Such composite gain configuration can efficiently remove waste heat from the gain medium, preventing thermal lensing and heat-induced birefringence/distortion under high power laser operation. Through near Brewster's angles incidence designing and polarization discrimination, two orthogonally linearly polarized (P and S polarized) laser beams are generated simultaneously from different parts of the same system...
January 23, 2017: Optics Express
https://www.readbyqxmd.com/read/28069573/relations-between-aortic-stiffness-and-left-ventricular-mechanical-function-in-the-community
#6
Vanessa Bell, Elizabeth L McCabe, Martin G Larson, Jian Rong, Allison A Merz, Ewa Osypiuk, Birgitta T Lehman, Plamen Stantchev, Jayashri Aragam, Emelia J Benjamin, Naomi M Hamburg, Ramachandran S Vasan, Gary F Mitchell, Susan Cheng
BACKGROUND: Aortic stiffness impairs optimal ventricular-vascular coupling and left ventricular systolic function, particularly in the long axis. Left ventricular global longitudinal strain (GLS) has recently emerged as a sensitive measure of early cardiac dysfunction. In this study, we investigated the relation between aortic stiffness and GLS in a large community-based sample. METHODS AND RESULTS: In 2495 participants (age 39-90 years, 57% women) of the Framingham Offspring and Omni cohorts, free of cardiovascular disease, we performed tonometry to measure arterial hemodynamics and echocardiography to assess cardiac function...
January 9, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28059373/theoretical-and-experimental-analysis-of-instability-of-continuous-wave-mode-locking-towards-high-fundamental-repetition-rate-in-tm-sup-3-sup-doped-fiber-lasers
#7
H Cheng, W Lin, T Qiao, S Xu, Z Yang
With increasing demand on a laser source in the gigahertz pulse repetition rate regime, clarification on the mechanism of instability in high repetition rate fiber lasers - a promising alternative to solid state lasers - is of great importance and can potentially offer guideline for continuous wave (CW) mode locking. Here we present a theoretical approach together with relevant experimental corroboration to analyze the instabilities. By means of appropriate approximations, regimes from Q-switched mode locking, CW mode locking and pulsation are theoretically identified...
December 26, 2016: Optics Express
https://www.readbyqxmd.com/read/28053148/inhibition-of-dermatophytes-by-photodynamic-treatment-with-curcumin
#8
Jochen Brasch, Sandra Freitag-Wolf, Vera Beck-Jendroschek, Martin Huber
Treatment of dermatophytoses with currently available antimycotic agents is often tedious and sometimes unsatisfactory. A search for better therapeutic methods-ideally with an immediate fungicidal effect-has, among others, lead to photodynamic procedures as a promising alternative, and recently curcumin was found to be a suitable agent for this application. In this study the effect of photodynamic treatment with curcumin on dermatophytes was tested in vitro Wells of microtiter plates were filled with conidia of Trichophyton rubrum, Trichophyton interdigitale, Trichophyton terrestre, Microsporum canis, Microsporum gypseum and Epidermophyton floccosum in buffer...
January 3, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28032342/beam-distortion-due-to-gold-fiducial-markers-during-salvage-high-intensity-focused-ultrasound-in-the-prostate
#9
P S Georgiou, J Jaros, H Payne, C Allen, T T Shah, H U Ahmed, E Gibson, D Barratt, B E Treeby
PURPOSE: High intensity focused ultrasound (HIFU) provides a non-invasive salvage treatment option for patients with recurrence after external beam radiation therapy (EBRT). As part of EBRT the prostate is frequently implanted with permanent fiducial markers. To date, the impact of these markers on subsequent HIFU treatment is unknown. The objective of this work was to systematically investigate, using computational simulations, how these fiducial markers affect the delivery of HIFU treatment...
February 2017: Medical Physics
https://www.readbyqxmd.com/read/27914386/single-sensor-cue-counting-population-density-estimation-average-probability-of-detection-of-broadband-clicks
#10
Elizabeth T Küsel, Martin Siderius, David K Mellinger
Odontocete echolocation clicks have been used as a preferred cue for density estimation using single-sensor data sets, requiring estimation of detection probability as a function of range. Many such clicks can be very broadband in nature, with 10-dB bandwidths of 20-40 kHz or more. Detection distances are not readily obtained from single-sensor data. Here, the average detection probability is estimated in a Monte Carlo simulation using the passive sonar equation along with transmission loss calculations to estimate the signal-to-noise ratio (SNR) of tens of thousands of click realizations...
September 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27903733/development-of-activity-in-the-mouse-visual-cortex
#11
Jing Shen, Matthew T Colonnese
A comprehensive developmental timeline of activity in the mouse cortex in vivo is lacking. Understanding the activity changes that accompany synapse and circuit formation is important to understand the mechanisms by which activity molds circuits and would help to identify critical checkpoints for normal development. To identify key principles of cortical activity maturation, we systematically tracked spontaneous and sensory-evoked activity with extracellular recordings of primary visual cortex (V1) in nonanesthetized mice...
November 30, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27895552/computational-models-of-auditory-scene-analysis-a-review
#12
REVIEW
Beáta T Szabó, Susan L Denham, István Winkler
Auditory scene analysis (ASA) refers to the process (es) of parsing the complex acoustic input into auditory perceptual objects representing either physical sources or temporal sound patterns, such as melodies, which contributed to the sound waves reaching the ears. A number of new computational models accounting for some of the perceptual phenomena of ASA have been published recently. Here we provide a theoretically motivated review of these computational models, aiming to relate their guiding principles to the central issues of the theoretical framework of ASA...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27813386/retroperitoneoscopic-pyelolithotomy-a-good-alternative-treatment-for-renal-pelvic-calculi-in-children
#13
Bruno Nicolino Cezarino, Rubens Park, Paulo Renato Marcelo Moscardi, Roberto Iglesias Lopes, Francisco T Denes, Miguel Srougi
INTRODUCTION: Nephrolitiasis, once considered an adult disease, has become increasingly prevalent in children, with na increase from 6% to 10 % annually in past 25 years. Kidney stones in pediatric population can result from metabolic diseases in up to 50% of children affected. Other factors associated with litiasis are infection, dietary factors, and anatomic malformations of urinary tract. Standard treatment procedures for pediatric population are similar to adult population. Extracorporeal shock wave lithotripsy (ESWL), ureterorenoscopy (URS), percutaneous nepfrolithotomy (PCNL), as well as laparoscopic and retroperitoneoscopic approaches can be indicated in selected cases...
November 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/27761408/all-optical-optoacoustic-microscopy-based-on-probe-beam-deflection-technique
#14
Saher M Maswadi, Bennett L Ibey, Caleb C Roth, Dmitri A Tsyboulski, Hope T Beier, Randolph D Glickman, Alexander A Oraevsky
Optoacoustic (OA) microscopy using an all-optical system based on the probe beam deflection technique (PBDT) for detection of laser-induced acoustic signals was investigated as an alternative to conventional piezoelectric transducers. PBDT provides a number of advantages for OA microscopy including (i) efficient coupling of laser excitation energy to the samples being imaged through the probing laser beam, (ii) undistorted coupling of acoustic waves to the detector without the need for separation of the optical and acoustic paths, (iii) high sensitivity and (iv) ultrawide bandwidth...
September 2016: Photoacoustics
https://www.readbyqxmd.com/read/27718510/mechanomyographic-responses-during-recruitment-curves-in-the-soleus-muscle
#15
Amelia A Miramonti, Nathaniel D M Jenkins, Preeti D Oza, Joseph P Weir, Joel T Cramer
INTRODUCTION: This study examined relationships among mechanomyographic (MMG), electromyographic (EMG), and peak twitch torque (PTT) responses as well as test-retest reliability when recorded during recruitment curves in the soleus muscle. METHODS: PTT, EMG (M-wave, H-reflex), and MMG responses were recorded during recruitment curves in 16 subjects (age=24±2y) on 2 separate days. The sum of the M-wave and H-reflex (M+H) was calculated. Correlations among variables and test-retest reliability were determined...
October 8, 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/27707533/spike-on-t-wave-what-went-wrong
#16
Pasquale Crea, Giuseppe Picciolo, Teresa Crea, Francesco Luzza
An 80-year-old male, who previously received a dual chamber pacemaker, was referred to our ambulatory for dizziness and fatigue. The ECG obtained showed sinus rhythm, highly variable atrioventricular (AV) interval and alternation between spontaneous and paced ventricular complexes. A spike on the ascending part of the T wave was observed, suggesting ventricular undersensing. However, telemetry-supported pacemaker control showed inconstant atrial undersensing.
January 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/27700052/cubic-re-6-5d-1-double-perovskites-ba2mgreo6-ba2znreo6-and-ba2y2-3reo6-magnetism-heat-capacity-%C3%AE-sr-and-neutron-scattering-studies-and-comparison-with-theory
#17
Casey A Marjerrison, Corey M Thompson, Gabrielle Sala, Dalini D Maharaj, Edwin Kermarrec, Yipeng Cai, Alannah M Hallas, Murray N Wilson, Timothy J S Munsie, Garrett E Granroth, Roxana Flacau, John E Greedan, Bruce D Gaulin, Graeme M Luke
Double perovskites (DP) of the general formula Ba2MReO6, where M = Mg, Zn, and Y2/3, all based on Re(6+) (5d(1), t2g(1)), were synthesized and studied using magnetization, heat capacity, muon spin relaxation, and neutron-scattering techniques. All are cubic, Fm3̅m, at ambient temperature to within the resolution of the X-ray and neutron diffraction data, although the muon data suggest the possibility of a local distortion for M = Mg. The M = Mg DP is a ferromagnet, Tc = 18 K, with a saturation moment ∼0...
October 4, 2016: Inorganic Chemistry
https://www.readbyqxmd.com/read/27622525/aspect-ratio-driven-evolution-of-high-order-resonant-modes-and-near-field-distributions-in-localized-surface-phonon-polariton-nanostructures
#18
Chase T Ellis, Joseph G Tischler, Orest J Glembocki, Francisco J Bezares, Alexander J Giles, Richard Kasica, Loretta Shirey, Jeffrey C Owrutsky, Dmitry N Chigrin, Joshua D Caldwell
Polar dielectrics have garnered much attention as an alternative to plasmonic metals in the mid- to long-wave infrared spectral regime due to their low optical losses. As such, nanoscale resonators composed of these materials demonstrate figures of merit beyond those achievable in plasmonic equivalents. However, until now, only low-order, phonon-mediated, localized polariton resonances, known as surface phonon polaritons (SPhPs), have been observed in polar dielectric optical resonators. In the present work, we investigate the excitation of 16 distinct high-order, multipolar, localized surface phonon polariton resonances that are optically excited in rectangular pillars etched into a semi-insulating silicon carbide substrate...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27617087/arrhythmogenic-cardiomyopathy-electrical-and-structural-phenotypes
#19
Deniz Akdis, Corinna Brunckhorst, Firat Duru, Ardan M Saguner
This overview gives an update on the molecular mechanisms, clinical manifestations, diagnosis and therapy of arrhythmogenic cardiomyopathy (ACM). ACM is mostly hereditary and associated with mutations in genes encoding proteins of the intercalated disc. Three subtypes have been proposed: the classical right-dominant subtype generally referred to as ARVC/D, biventricular forms with early biventricular involvement and left-dominant subtypes with predominant LV involvement. Typical symptoms include palpitations, arrhythmic (pre)syncope and sudden cardiac arrest due to ventricular arrhythmias, which typically occur in athletes...
August 2016: Arrhythmia & Electrophysiology Review
https://www.readbyqxmd.com/read/27599606/f-t-teleparallel-gravity-and-cosmology
#20
Yi-Fu Cai, Salvatore Capozziello, Mariafelicia De Laurentis, Emmanuel N Saridakis
Over recent decades, the role of torsion in gravity has been extensively investigated along the main direction of bringing gravity closer to its gauge formulation and incorporating spin in a geometric description. Here we review various torsional constructions, from teleparallel, to Einstein-Cartan, and metric-affine gauge theories, resulting in extending torsional gravity in the paradigm of f (T) gravity, where f (T) is an arbitrary function of the torsion scalar. Based on this theory, we further review the corresponding cosmological and astrophysical applications...
October 2016: Reports on Progress in Physics
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