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https://www.readbyqxmd.com/read/28870114/alleviating-mechanical-allodynia-and-modulating-cellular-immunity-contribute-to-electroacupuncture-s-dual-effect-on-bone-cancer-pain
#1
Yi Liang, Jun-Ying Du, Jun-Fan Fang, Ruo-Yi Fang, Jie Zhou, Xiao-Mei Shao, Yong-Liang Jiang, Yi-Tian Chen, Jian-Qiao Fang
HYPOTHESIS: Electroacupuncture (EA) has been used as an alternative analgesic therapy for hundreds of years, yet its analgesic potency and therapeutic advantage against bone cancer pain (BCP) in comparison with morphine remains unclear. This study aimed to investigate the effects of EA on mechanical allodynia and cellular immunity of BCP rats, and to further explore the potential mechanism. METHODS: The BCP model was established by implanting Walker 256 mammary gland carcinoma cells into the left tibia of adult female Sprague-Dawley rats...
September 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/28854826/high-intensity-focused-ultrasound-in-the-treatment-of-breast-fibroadenomata-hifu-f-trial
#2
McL Peek, M Ahmed, J Scudder, R Baker, P Charalampoudis, S E Pinder, M Douek
Abstact Background: High intensity focused ultrasound (HIFU) is a non-invasive ablative technique utilising the application of high frequency ultrasound (US) pressure waves to cause tissue necrosis. This emerging technology is currently limited by prolonged treatment times. The aim of the HIFU-F trial was to perform circumferential HIFU treatment as a means of shortening treatment times. METHODS: A prospective trial was set up to treat 50 consecutive patients ≥18 years of age. Eligible patients possessed symptomatic fibroadenomata, visible on US...
August 30, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28836911/infarction-or-pseudo-infarction
#3
Ross MacKenzie
An applicant with a history of paroxysmal atrial fibrillation is found to have QS waves in leads III and AVF suggestive of a prior inferior wall myocardial infarction. Using the relationship between Q wave and T wave vectors in the inferior leads, an alternative explanation is explored.
2017: Journal of Insurance Medicine
https://www.readbyqxmd.com/read/28802655/alternating-trifascicular-block-and-cardiac-memory
#4
Asaf Danon, Mohammed Shurrab
We describe a case of a 70year-old woman with effort dyspnea and alternating trifascicular conduction pattern, worsened with exercise to atrioventricular block (AV Block). The alternating conduction at rest resulted in marked T wave changes. We discuss the mechanism of T wave memory changes and the management of exercise-induced AV Block.
July 12, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28794084/mechanically-induced-ectopy-via-stretch-activated-cation-nonselective-channels-is-caused-by-local-tissue-deformation-and-results-in-ventricular-fibrillation-if-triggered-on-the-repolarization-wave-edge-commotio-cordis
#5
T Alexander Quinn, Honghua Jin, Peter Lee, Peter Kohl
BACKGROUND: External chest impacts (commotio cordis) can cause mechanically induced premature ventricular excitation (PVEM) and, rarely, ventricular fibrillation (VF). Because block of stretch-sensitive ATP-inactivated potassium channels curtailed VF occurrence in a porcine model of commotio cordis, VF has been suggested to arise from abnormal repolarization caused by stretch activation of potassium channels. Alternatively, VF could result from abnormal excitation by PVEM, overlapping with normal repolarization-related electric heterogeneity...
August 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28763347/ex-vivo-induction-of-multiple-myeloma-specific-immune-responses-by-monocyte-derived-dendritic-cells-following-stimulation-by-whole-tumor-antigen-of-autologous-myeloma-cells
#6
Spyridoula Vasileiou, Ioannis Baltadakis, Sosanna Delimpasi, Maria-Helena Karatza, Konstantinos Liapis, Maria Garofalaki, Eirini Tziotziou, Zoe Poulopoulou, Dimitri Karakasis, Nicholas Harhalakis
The introduction of novel agents has significantly expanded treatment options for multiple myeloma (MM), albeit long-term disease control cannot be achieved in the majority of patients. Vaccination with MM antigen-loaded dendritic cells (DCs) represents an alternative strategy that is currently being explored. The aim of this study was to assess the immunogenic potential of ex vivo-generated monocyte-derived DCs (moDCs), following stimulation with the whole-antigen array of autologous myeloma cells (AMC). MoDCs were loaded with antigens of myeloma cells by 2 different methods: phagocytosis of apoptotic bodies from γ-irradiated AMC, or transfection with AMC total RNA by square-wave electroporation...
July 31, 2017: Journal of Immunotherapy
https://www.readbyqxmd.com/read/28749343/a-potential-based-inverse-spectral-method-to-non-invasively-localize-discordant-distributions-of-alternans-on-the-heart-from-the-ecg
#7
Jaume Coll-Font, Burak Erem, Dana H Brooks
T-wave alternans (TWA), defined as the beat-to-beat alternation in amplitude of the T-waves, has been shown to be linked to ventricular fibrillation (VF). However, current TWA tests have high sensitivity but low specificity in determining who is at risk. To overcome this limitation, it might be helpful to determine the spatial distribution of any regions on the heart that alternate in opposite phase. Understanding these spatial distributions in relation to the regular activation of the heart could help explain the mechanism for the genesis of VF and thus disambiguate the low specificity of TWA...
July 26, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28737378/quantitative-mid-infrared-cavity-ringdown-detection-of-methyl-iodide-for-monitoring-applications
#8
Ibrahim Sadiek, Qiang Shi, Douglas W R Wallace, Gernot Friedrichs
Methyl iodide is a toxic halocarbon with diverse industrial and agricultural applications, and it is an important ocean-derived trace gas that contributes to the iodine burden of the atmosphere. Quantitative analysis of CH3I is mostly based on gas chromatography coupled with mass spectrometry or electron capture detection (GC-MS/ECD) as of yet, which often limits the ability to conduct in situ high-frequency monitoring studies. This work presents an alternative detection scheme based on mid-infrared continuous wave cavity ringdown spectroscopy (mid-IR cw-CRDS)...
August 4, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28735929/electrophysiological-and-microstructural-features-of-sleep-in%C3%A2-children%C3%A2-at-high-risk-for-depression-a-preliminary-study
#9
Gianluca Sesso, Flora Bat-Pitault, Aurore Guyon, Sabine Plancoulaine, Tommaso Banfi, Giulia Milioli, Liborio Parrino, Ugo Faraguna, Patricia Franco
OBJECTIVE: This preliminary study investigated electrophysiological and microstructural features of sleep in children and adolescents 4-18 years of age who were born to depressed mothers. METHODS: A total of 31 healthy subjects (15 male and 16 female) participated in the study. In this sample, 20 children born to mothers diagnosed with Major Depressive Disorder (MDD) were designated as "high-risk"; 11 children born to mothers without a personal history of depression were designated as "low-risk...
August 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28732751/voice-improvement-in-patients-with-functional-dysphonia-treated-with-the-proprioceptive-elastic-proel-method
#10
E Lucchini, A Ricci Maccarini, E Bissoni, M Borragan, M Agudo, M J González, V Romizi, A Schindler, M Behlau, T Murry, A Borragan
The objective of the study was to analyze the outcome of the proprioceptive-elastic (PROEL) voice therapy method in patients with functional dysphonia (FD). Fifty-two patients with FD were involved in the study; they were composed of three subgroups of patients with (1) FD without glottal insufficiency (n = 28), (2) FD and glottal insufficiency (n = 9), and (3) FD, glottal insufficiency, and vocal nodules (n = 15). A multidimensional assessment protocol including videolaryngostroboscopy; maximum phonation time; perceptual evaluation of dysphonia with the Grade, Instability, Roughness, Breathiness, Asthenia, and Strain (GIRBAS) scale; and 10-item version of the Voice Handicap Index was conducted before and after 15 sessions of voice therapy...
July 18, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28707943/calorimetric-measurements-of-magnetic-field-induced-inhomogeneous-superconductivity-above-the-paramagnetic-limit
#11
Charles C Agosta, Nathanael A Fortune, Scott T Hannahs, Shuyao Gu, Lucy Liang, Ju-Hyun Park, John A Schleuter
We report the first magnetocaloric and calorimetric observations of a magnetic-field-induced phase transition within a superconducting state to the long-sought exotic Fulde-Ferrell-Larkin-Ovchinnikov (FFLO) superconducting state, first predicted over 50 years ago. Through the combination of bulk thermodynamic calorimetric and magnetocaloric measurements in the organic superconductor κ-(BEDT-TTF)_{2}Cu(NCS)_{2} as a function of temperature, magnetic field strength, and magnetic field orientation, we establish for the first time that this field-induced first-order phase transition at the paramagnetic limit H_{p} is a transition to a higher-entropy superconducting phase, uniquely characteristic of the FFLO state...
June 30, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28687562/efficacy-and-safety-of-the-subcutaneous-implantable-cardioverter-defibrillator-a-systematic-review
#12
REVIEW
Colin Dominic Chue, Chun Shing Kwok, Chun Wai Wong, Ashish Patwala, Diane Barker, Amir Zaidi, Mamas A Mamas, Colin Cunnington, Fozia Z Ahmed
BACKGROUND: Subcutaneous implantable cardioverter defibrillators (S-ICDs) are considered an alternative to conventional transvenous ICDs (TV-ICDs) in patients not requiring pacing. METHODS: We searched MEDLINE and EMBASE for studies evaluating efficacy and safety outcomes in S-ICD patients. Outcomes were pooled across studies. RESULTS: Sixteen studies were included with 5380 participants (mean age range 33-56 years). Short-term follow-up data were available for 1670 subjects...
September 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28608507/revisiting-the-thermochemistry-of-chlorine-fluorides
#13
Hernán R Sánchez
In this work, accurate calculations of standard enthalpies of formation of chlorine fluorides (ClFn, n = 1-7; Cl2 F and Cl3 F2 ) were performed through the isodesmic reactions scheme. It is argued that, for many chlorine fluorides, the gold standard method of quantum chemistry (CCSD(T)) is not capable to predict enthalpy values nearing chemical accuracy if atomization scheme is used. This is underpinned by a thorough analysis of total atomization energy results and the inspection of multireference features of these compounds...
June 13, 2017: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/28557006/neutral-processes-forming-large-clones-during-colonization-of-new-areas
#14
M Rafajlović, D Kleinhans, C Gulliksson, J Fries, D Johansson, A Ardehed, L Sundqvist, R T Pereyra, B Mehlig, P R Jonsson, K Johannesson
In species reproducing both sexually and asexually clones are often more common in recently established populations. Earlier studies have suggested that this pattern arises due to natural selection favouring generally or locally successful genotypes in new environments. Alternatively, as we show here, this pattern may result from neutral processes during species' range expansions. We model a dioecious species expanding into a new area in which all individuals are capable of both sexual and asexual reproduction, and all individuals have equal survival rates and dispersal distances...
May 30, 2017: Journal of Evolutionary Biology
https://www.readbyqxmd.com/read/28497528/frequency-swept-integrated-solid-effect
#15
Thach V Can, Ralph T Weber, Joseph J Walish, Timothy M Swager, Robert G Griffin
The efficiency of continuous wave dynamic nuclear polarization (DNP) experiments decreases at the high magnetic fields used in contemporary high-resolution NMR applications. To recover the expected signal enhancements from DNP, we explored time domain experiments such as NOVEL which matches the electron Rabi frequency to the nuclear Larmor frequency to mediate polarization transfer. However, satisfying this matching condition at high frequencies is technically demanding. As an alternative we report here frequency-swept integrated solid effect (FS-ISE) experiments that allow low power sweeps of the exciting microwave frequencies to constructively integrate the negative and positive polarizations of the solid effect, thereby producing a polarization efficiency comparable to (±10 % difference) NOVEL...
June 6, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28477226/-malignant-bileaflet-mitral-valve-prolapse-syndrome-in-otherwise-idiopathic-ventricular-fibrillation
#16
Dirk Vollmann, Claudius Hansen, Lars Lüthje, Ole A Breithardt
A 32-year-old, otherwise healthy woman was admitted after successful out-of-hospital resuscitation due to ventricular fibrillation. Established cardiac, pulmonary, metabolic, and toxicological causes were excluded. However, persisting (biphasic) negative T waves in the inferior ECG leads and premature ventricular contractions (PVC) were noted. PVC morphology indicated a focus alternating between the posterior papillary muscle/the left posterior fascicle and the left ventricular outflow tract region/anterior papillary muscle...
May 5, 2017: Herzschrittmachertherapie & Elektrophysiologie
https://www.readbyqxmd.com/read/28471653/variable-velocity-traveling-wave-ion-mobility-separation-enhancing-peak-capacity-for-data-independent-acquisition-proteomics
#17
Sarah E Haynes, Daniel A Polasky, Sugyan M Dixit, Jaimeen D Majmudar, Kieran Neeson, Brandon T Ruotolo, Brent R Martin
High mass accuracy, data-dependent acquisition is the current standard method in mass spectrometry-based peptide annotation and quantification. In high complexity samples, limited instrument scan speeds often result in under-sampling. In contrast, all-ion data-independent acquisition methods bypass precursor selection, alternating high and low collision energies to analyze product and precursor ions across wide mass ranges. Despite capturing data for all events, peptide annotation is limited by inadequate alignment algorithms or overlapping ions...
June 6, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28444869/assessment-of-the-usage-of-biodegradable-polymeric-matrix-in-vaginal-devices-to-sustain-progesterone-release-in-cows
#18
José Rodrigo Valim Pimentel, Milton Maturana Filho, Lucio Cardozo-Filho, José Augusto M Agnelli, Jefter Nascimento, Ed Hoffmann Madureira
The usage of timed artificial insemination (TAI) at a low cost leading to better reproductive rates has been the aim of several research groups in the field. Usually during TAI protocols, sustained progesterone (P4 ) release devices are employed. Most devices are constituted of a nylon skeleton covered with a silicon layer with P4 . A device based on biopolymers was developed in order to reduce costs and decrease its environmental impact. In this study, we compared the kinetics of sustained progesterone release among devices manufactured with a polymeric blend made of polyhydroxybutyrate-valerate (PHBV) and poly-ε-caprolactone (PCL) (DISP) which were compared with DIB® (Internal Bovine Device) used as the control...
April 25, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28434724/the-effect-of-presynchronization-with-prostaglandin-f2%C3%AE-and-gonadotropin-releasing-hormone-simultaneously-7-d-before-ovsynch-compared-with-presynch-10-ovsynch-on-luteal-function-and-first-service-pregnancies-per-artificial-insemination
#19
J P N Martins, M J T Acevedo, T O Cunha, C Piterini, J R Pursley
Pregnancy per artificial insemination (P/AI) following Ovsynch is optimized when cows ovulate to the first GnRH of Ovsynch. Fertility programs are designed to presynchronize cows to d 6 or 7 of the estrous cycle to increase the chances of ovulation of a first-wave dominant follicle to the first GnRH of Ovsynch. The hypothesis of this experiment was that simplification of a presynchronization program through the combination of PGF2α and GnRH on the same day, 7 d before Ovsynch, would allow for similar P/AI compared with Presynch-10...
April 20, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28433007/alternative-definition-of-excitation-amplitudes-in-multi-reference-state-specific-coupled-cluster
#20
Yann Garniron, Emmanuel Giner, Jean-Paul Malrieu, Anthony Scemama
A central difficulty of state-specific Multi-Reference Coupled Cluster (MR-CC) in the multi-exponential Jeziorski-Monkhorst formalism concerns the definition of the amplitudes of the single and double excitation operators appearing in the exponential wave operators. If the reference space is a complete active space (CAS), the number of these amplitudes is larger than the number of singly and doubly excited determinants on which one may project the eigenequation, and one must impose additional conditions. The present work first defines a state-specific reference-independent operator T∼^(m) which acting on the CAS component of the wave function |Ψ0(m)⟩ maximizes the overlap between (1+T∼^(m))|Ψ0(m)⟩ and the eigenvector of the CAS-SD (Singles and Doubles) Configuration Interaction (CI) matrix |ΨCAS-SD(m)⟩...
April 21, 2017: Journal of Chemical Physics
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