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https://www.readbyqxmd.com/read/29027300/pattern-of-in-hospital-changes-in-drug-use-in-the-older-people-from-2010-to-2016
#1
C Franchi, I Ardoino, A Nobili, L Pasina, P M Mannucci, A Maregoni, F Perticone
PURPOSE: To assess the pattern of in-hospital changes in drug use in older patients from 2010 to 2016. METHODS: People aged 65 years or more acutely hospitalized in those internal medicine and geriatric wards that did continuously participate to the REgistro POliterapie Società Italiana di Medicina Interna register from 2010 to 2016 were selected. Drugs use were categorized as 0 to 1 drug (very low drug use), 2 to 4 drugs (low drug use), 5 to 9 drugs (polypharmacy), and 10 or more drugs (excessive polypharmacy)...
October 13, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28840465/gold-and-female-reproductive-organs-an-ultrastructural-study
#2
Nedra Badri, Maroua Mhamdi, Ridha Ben Ali, Horea Matei, Walid-Habib Tekaya, Adrian Florea, Samira Maghraoui, Leila Tekaya
Gold, a heavy yellow-colored metal, is usually found in nature as a metallic element or as salts. This noble metal historically had a reputation as an anti-inflammatory medicine for rheumatoid arthritis, a nervine, and a remedy for nervous disorders, as well as a potential anticancer agent. It has also been used as component in dental restorations and in implant materials. The present study was undertaken to point out histological and ultrastructural effects of gold, administered by intraperitoneal route, in pregnant female reproductive organs (ovary and uterus), in order to clarify its side effects on the reproductive function...
August 24, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28734479/the-internal-medicine-of-the-21st-century-organizational-and-operational-standards
#3
E Casariego-Vales, A Zapatero-Gaviria, F J Elola-Somoza
The Spanish Society of Internal Medicine has developed a consensus document on the standards and recommendations that they consider essential to the organisation of internal medicine units for conducting their activities efficiently and with high quality. We defined 3 groups of key processes: the care of acutely ill adult patients, the comprehensive care of complex chronic patients and the examination of a patient with a difficult diagnosis and no organ-specific disease. As support processes, we identified the structure and operation of the Internal Medicine units...
July 19, 2017: Revista Clínica Española
https://www.readbyqxmd.com/read/28645616/epidemiological-and-sociodemographic-factors-associated-with-complicated-alcohol-withdrawal-syndrome
#4
R Monte-Secades, M Blanco-Soto, J A Díaz-Peromingo, A Sanvisens-Bergé, M C Martín-González, A Barbosa, B Rosón-Hernández, M A Tejero-Delgado, R Puerta-Louro, R Rabuñal-Rey
OBJECTIVES: To analyse the influence of epidemiological and sociodemographic factors in complicated alcohol withdrawal syndrome (AWS). MATERIAL AND METHODS: A multicentre, observational prospective study was conducted on consecutively added patients with AWS hospitalised in internal medicine departments. We recorded sociodemographic, epidemiological, clinical and progression data. Complicated AWS was defined as that which progressed with seizures or delirium tremens...
October 2017: Revista Clínica Española
https://www.readbyqxmd.com/read/28396131/effectiveness-of-a-simple-intervention-on-management-of-acute-exacerbations-of-chronic-obstructive-pulmonary-disease-and-its-cardiovascular-comorbidities-corepoc-study
#5
Jesús Díez-Manglano, Jesús Recio Iglesias, José Manuel Varela Aguilar, Pere Almagro Mena, Gabriel Zubillaga Garmendia
BACKGROUND AND OBJECTIVE: To determine the effectiveness of a simple educational intervention to improve the management of cardiovascular comorbidities in patients hospitalized with an acute exacerbation of chronic obstructive pulmonary disease (COPD). MATERIAL AND METHODS: Multicenter study participated in by 26 hospital centers. A panel of experts elaborated a set of recommendations about diagnostic and therapeutic management of acute exacerbation of COPD and cardiovascular comorbidities (coronary artery disease, atrial fibrillation, heart failure and diabetes)...
September 20, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28299634/prevalence-and-determinants-of-the-use-of-lipid-lowering-agents-in-a-population-of-older-hospitalized-patients-the-findings-from-the-reposi-registro-politerapie-societ%C3%A3-italiana-di-medicina-interna-study
#6
Marco Bertolotti, Carlotta Franchi, Marco B L Rocchi, Andrea Miceli, M Vittoria Libbra, Alessandro Nobili, Giulia Lancellotti, Lucia Carulli, Chiara Mussi
BACKGROUND: Older patients are prone to multimorbidity and polypharmacy, with an inherent risk of adverse events and drug interactions. To the best of our knowledge, available information on the appropriateness of lipid-lowering treatment is extremely limited. AIM: The aim of the present study was to quantify and characterize lipid-lowering drug use in a population of complex in-hospital older patients. METHODS: We analyzed data from 87 units of internal medicine or geriatric medicine in the REPOSI (Registro Politerapie della Società Italiana di Medicina Interna) study, with reference to the 2010 and 2012 patient cohorts...
April 2017: Drugs & Aging
https://www.readbyqxmd.com/read/27816186/-transition-process-from-paediatric-to-adult-care-in-patients-with-inborn-errors-of-metabolism-consensus-statement
#7
Jordi Pérez-López, Leticia Ceberio-Hualde, José Salvador García Morillo, Josep M Grau-Junyent, Álvaro Hermida Ameijeiras, Mónica López-Rodríguez, Montserrat Morales-Conejo, Juan José Nava Mateos, Luis José Aldámiz Echevarri Azuara, Jaume Campistol, M Luz Couce, María Teresa García-Silva, Luis González Gutiérrez-Solana, Mireia Del Toro
BACKGROUND AND OBJECTIVE: The transition process from paediatric to adult care is a subject of great interest in recent years, especially in chronic diseases with childhood onset, such as inborn errors of metabolism (IEM). Advances in diagnosis and treatment of these diseases have improved their prognosis, with a high number of patients with IEM who currently reach adult age and need to be attended to by non-paediatric professionals. The objective of this work is to establish action guidelines so that the specialists involved can guarantee a successful transition of these patients' healthcare...
December 2, 2016: Medicina Clínica
https://www.readbyqxmd.com/read/27318510/effect-of-an-intervention-on-quality-indicators-for-improving-the-treatment-of-hyperglycemia-in-patients-hospitalized-in-noncritical-areas
#8
J Ena, R Gómez-Huelgas, A Zapatero-Gaviria, P Vázquez-Rodriguez, C González-Becerra, M Romero-Sánchez, M J Igúzquiza-Pellejero, A Artero-Mora, J M Varela-Aguilar
OBJECTIVES: We evaluated the effect of an intervention on certain quality indicators employed for improving the treatment of hospital hyperglycemia. MATERIAL AND METHODS: A multicenter cross-sectional study was conducted on patients with hyperglycemia hospitalized in the internal medicine departments of 44 hospitals evaluated in 2 time periods: 2014 (baseline period) and 2015 (postintervention period). The intervention consisted of the dissemination of the indicators obtained in 2014 and the objectives for improvement...
October 2016: Revista Clínica Española
https://www.readbyqxmd.com/read/27129628/-medical-expert-consensus-in-ah-on-the-clinical-use-of-triple-fixed-dose-antihypertensive-therapy-in-spain
#9
P Mazón, E Galve, J Gómez, M Gorostidi, J L Górriz, J D Mediavilla
INTRODUCTION: The opinion of experts (different specialties) on the triple fixed-dose antihypertensive therapy in clinical practice may differ. MATERIALS AND METHODS: Online questionnaire with controversial aspects of the triple therapy answered by panel of experts in hypertension (HT) using two-round modified Delphi method. RESULTS: The questionnaire was completed by 158 experts: Internal Medicine (49), Nephrology (26), Cardiology (83). Consensus was reached (agreement) on 27/45 items (60%); 7 items showed differences statistically significant...
October 2016: Hipertensión y Riesgo Vascular
https://www.readbyqxmd.com/read/26165165/general-principles-of-medical-interconsultation-for-hospitalised-patients
#10
R Monte-Secades, E Montero-Ruiz, A Gil-Díaz, J Castiella-Herrero
Medical interconsultation for hospitalised patients is a regular activity among internal medicine specialists. However, despite its growing impact and importance, a model that defines its characteristics, objectives and information has not been established. This study, conducted by the Shared Care and Interconsultations Group of the Spanish Society of Internal Medicine, proposes a number of general recommendations concerning the method for requesting and responding to hospital medical interconsultations, as well as a format for these interconsultations...
January 2016: Revista Clínica Española
https://www.readbyqxmd.com/read/26163733/shared-care-comanagement
#11
E Montero Ruiz
Surgical departments have increasing difficulties in caring for their hospitalised patients due to the patients' advanced age and comorbidity, the growing specialisation in medical training and the strong political-healthcare pressure that a healthcare organisation places on them, where surgical acts take precedence over other activities. The pressure exerted by these departments on the medical area and the deficient response by the interconsultation system have led to the development of a different healthcare organisation model: Shared care, which includes perioperative medicine...
January 2016: Revista Clínica Española
https://www.readbyqxmd.com/read/25938844/health-related-quality-of-life-in-leukemia-survivors-of-allogeneic-hematopoietic-stem-cell-transplantation-employing-the-mexican-reduced-intensity-conditioning
#12
Mónica P González-Ramírez, Karla Miravete-Lagunes, Andrés Gómez-de-León, Sergio Ponce-de-León, Andrea P Tenorio-Rojo, Nora A Martagón-Herrera, Jesús A Hernández-Reyes, Arturo García-Villasenor, Esteban Burguette, María Fernanda Vallejo-Villalobos, Guillermo J Ruiz-Delgado, David Gómez-Almaguer, Guillermo J Ruiz-Argüelles
BACKGROUND: Quality of life (QOL) is an important consideration in the counseling, implementation, and post-treatment management of arduous treatments for life-threatening conditions such as allogeneic hematopoietic cell transplantation (allo-HCT). OBJECTIVE: To analyze the QOL of leukemia patients allografted with the Mexican reduced-intensity conditioning regimen in two Mexican academic medical centers. MATERIAL AND METHODS: By means of the quality metric short form 36 version 2 to measure generic health concepts, relevant QOL was analyzed in leukemia patients who underwent allo-HCT using reduced-intensity conditioning on an outpatient basis at either the Centro de Hematología y Medicina Interna de Puebla of the Clínica Ruiz or the Hematology Service of the Internal Medicine Department of the Hospital "Dr...
March 2015: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/25300912/definitions-of-internal-medicine-activities-outside-of-the-im-department
#13
E Montero Ruiz, R Monte Secades
The inpatient profile is changing towards patients with multiple diseases, the elderly and those with high comorbidity. The growing complexity of their care, the progressive medical superspecialization and the organizational problems that often hinder daily patient follow-up by the same physician have contributed to a progressive increase in the participation of medical departments, especially Internal Medicine, in the care of patients hospitalized in other medical and surgical specialties. The hospital activities that the departments of internal medicine perform outside of their own department do not have well-established definitions and criteria at the organizational level; their assessment and accountability are different in each hospital...
April 2015: Revista Clínica Española
https://www.readbyqxmd.com/read/24338497/prognostic-value-of-estimated-glomerular-filtration-rate-in-hospitalized-elderly-patients
#14
MULTICENTER STUDY
Laura De La Higuera, Emma Riva, Codjo Djignefa Djade, Sara Mandelli, Carlotta Franchi, Alessandra Marengoni, Francesco Salerno, Salvatore Corrao, Luca Pasina, Mauro Tettamanti, Maura Marcucci, Pier Mannuccio Mannucci, Alessandro Nobili
A multicenter observational study, REPOSI (REgistro POliterapie Società Italiana di Medicina Interna), was conducted to assess the prognostic value of glomerular filtration rate (eGFR) on in-hospital mortality, hospital re-admission and death within 3 months, in a sample of elderly patients (n = 1,363) admitted to 66 internal medicine and geriatric wards. Based on eGFR, calculated by the new Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula, subjects at hospital admission were classified into three groups: group 1 with normal eGFR (≥60 ml/min/1...
October 2014: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/23768854/-diuretic-therapy-in-heart-failure
#15
REVIEW
Joan Carles Trullàs, José Luís Morales-Rull, Francesc Formiga
Many of the primary clinical manifestations of heart failure (HF) are due to fluid retention, and treatments targeting congestion play a central role in HF management. Diuretic therapy remains the cornerstone of congestion treatment, and diuretics are prescribed to the majority of HF patients. Despite this ubiquitous use, there is limited evidence from prospective randomized studies to guide the use of diuretics. With the chronic use of diuretic and usually in advanced stages of HF, diuretics may fail to control salt and water retention...
February 20, 2014: Medicina Clínica
https://www.readbyqxmd.com/read/23743547/current-status-of-general-pathology-training-in-spain
#16
J Casademont, J M Porcel, J A Vargas Núñez, J González Macías
BACKGROUND AND OBJECTIVES: One of the core subjects in university training of the physicians has been General Pathology. Responsibility for this has historically fallen on Internal Medicine specialists. However, we are unaware if this situation is currently maintained. METHODS: A questionnaire was sent to the coordinators of the subject of the 39 Spanish medical schools to know, among other things, the current denomination of the subjects (traditionally known as «General Pathology»), number of credits, teaching activities included in the subject and number and specialty of the professors responsible for it...
December 2013: Revista Clínica Espanõla
https://www.readbyqxmd.com/read/23653407/prophylaxis-of-venous-thromboembolism-in-elderly-patients-with-multimorbidity
#17
Maura Marcucci, Alfonso Iorio, Alessandro Nobili, Mauro Tettamanti, Luca Pasina, Codjo Djignefa Djade, Alessandra Marengoni, Francesco Salerno, Salvatore Corrao, Pier Mannuccio Mannucci
Pharmacological thromboprophylaxis (TP) is known to reduce venous thromboembolism (VTE) in medical inpatients, but the criteria for risk-driven prescription, safety and impact on mortality are still debated. We analyze data on elderly patients with multimorbidities admitted in the year 2010 to the Italian internal medicine wards participating in the REPOSI registry to investigate the rate of TP during the hospital stay, and analyze the factors that are related to its prescription. Multivariate logistic regression, area under the ROC curve and CART analysis were performed to look for independent predictors of TP prescription...
September 2013: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/23303399/comorbidities-and-short-term-prognosis-in-patients-hospitalized-for-acute-exacerbation-of-copd-the-epoc-en-servicios-de-medicina-interna-esmi-study
#18
MULTICENTER STUDY
Pedro Almagro, Francisco Javier Cabrera, Jesus Diez, Ramon Boixeda, M Belen Alonso Ortiz, Cristina Murio, Joan B Soriano
BACKGROUND: Comorbidities are frequent in patients hospitalized for COPD exacerbation, but little is known about their relation with short-term mortality and hospital readmissions. Our hypothesis is that the frequency and type of comorbidities impair the prognosis within 12 weeks after discharge. METHODS: A longitudinal, observational, multicenter study of patients hospitalized for a COPD exacerbation with spirometric confirmation was performed. Comorbidity information was collected using the Charlson index and a questionnaire that included other common conditions not included in this index...
November 2012: Chest
https://www.readbyqxmd.com/read/23266125/-recommendations-on-the-use-of-belimumab-in-systemic-lupus-erythematosus-geas-semi-clinical-practice-guide
#19
M Ramos-Casals, G Ruiz-Irastorza, J Jiménez-Alonso, M A Khamashta
Biological therapies are based on the administration of various types of synthetic molecules related to the immune response. Their use has spread in recent years to the field of systemic autoimmune diseases, particularly to systemic lupus erythematosus (SLE). Until 2011, these diseases were not included in the therapeutic indications approved by international regulatory agencies. Therefore, the use of biological therapies was restricted to clinical trials and to compassionate use for cases refractory to standard treatments (off-label use), which require the approval of the Health Ministry...
January 2013: Revista Clínica Espanõla
https://www.readbyqxmd.com/read/23239364/association-of-anticholinergic-burden-with-cognitive-and-functional-status-in-a-cohort-of-hospitalized-elderly-comparison-of-the-anticholinergic-cognitive-burden-scale-and-anticholinergic-risk-scale-results-from-the-reposi-study
#20
Luca Pasina, Codjo D Djade, Ugo Lucca, Alessandro Nobili, Mauro Tettamanti, Carlotta Franchi, Francesco Salerno, Salvatore Corrao, Alessandra Marengoni, Alfonso Iorio, Maura Marcucci, Francesco Violi, Pier Mannuccio Mannucci
BACKGROUND: Drugs with anticholinergic effects are associated with adverse events such as delirium and falls as well as cognitive decline and loss of independence. OBJECTIVE: The aim of the study was to evaluate the association between anticholinergic burden and both cognitive and functional status, according to the hypothesis that the cumulative anticholinergic burden, as measured by the Anticholinergic Cognitive Burden (ACB) Scale and Anticholinergic Risk Scale (ARS), increases the risk of cognitive decline and impairs activities of daily living...
February 2013: Drugs & Aging
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