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https://www.readbyqxmd.com/read/28298747/benefits-and-pitfalls-of-cadavers-as-learning-tool-for-ultrasound-guided-regional-anesthesia
#1
REVIEW
Chhavi Sawhney, Sanjeev Lalwani, Bikash Ranjan Ray, Sumit Sinha, Abhyuday Kumar
Ultrasound-guided regional anesthesia (UGRA), like other basic skills, should be learnt in a simulation laboratory before performing on the patient. Cadavers provide an ideal tool for learning sonoanatomy and skills required for performing UGRA. On the basis of preservation technique used, the cadavers can be formalin embalmed cadavers, Thiel cadavers (soft cadavers), and fresh frozen cadavers. We compared three types of cadavers for performing ultrasound-guided upper and lower limb blocks. We observed that fresh frozen and Thiel cadavers were less smelling and had more realistic appearance as compared to formalin embalmed cadavers...
January 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/28258612/vitamin-d-receptor-gene-polymorphisms-in-immune-thrombocytopenic-purpura
#2
Sule Yesil, Hikmet Gulsah Tanyildiz, Sibel Akpinar Tekgunduz, Sule Toprak, Ali Fettah, Asiye Ugras Dikmen, Gurses Sahin
BACKGROUND: Vitamin D receptor (VDR) gene polymorphisms have been studied in immune-mediated disorders, but not yet in immune thrombocytopenic purpura (ITP). We investigated whether VDR variants were associated with ITP in children. METHODS: The study included 44 children with a diagnosis of ITP and 100 healthy controls. Five VDR polymorphisms (Cdx-2, FokI, BsmI, ApaI and TaqI) were genotyped and used to evaluate the association of VDR variants with ITP. RESULTS: The distribution of the three Cdx-2 genotyping groups (GG, GA, and AA) was significantly different between ITP patients and controls (p=0...
March 4, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28188388/longer-duration-of-untreated-psychosis-hinders-improvement-in-treatment-of-chronic-schizophrenia-community-based-early-intervention-is-an-evidence-based-option
#3
Abdülkadir Tabo, Erkan Aydın, Hüseyin Yumrukçal, Sadık Yiğit, Uğraş Erman Uzun, Oğuz Karamustafalıoğlu
To determine the effects of community-based mental health services on the quality of life and disease symptoms of chronic schizophrenia patients and to determine the effects of duration of untreated psychosis on outcome. The first year records of schizophrenia patients who had been followed up at Zeytinburnu CMHC for at least 12 months, have been used to asses outcome using initial and 12th month quality of life (QoL), positive and negative symptom scale (PANSS) scores. Highly significant improvements were shown in the QoL and PANSS scores...
February 10, 2017: Community Mental Health Journal
https://www.readbyqxmd.com/read/28137415/analysis-of-mmp-7-and-timp-2-gene-polymorphisms-in-coronary-artery-disease-and-myocardial-infarction-a-turkish-case-control-study
#4
Ebru Alp, Akin Yilmaz, Murat Tulmac, Asiye Ugras Dikmen, Atiye Cengel, Ridvan Yalcin, Emine Sevda Menevse
Matrix metalloproteinase (MMP) and tissue inhibitors of metalloproteinase (TIMP) have a significant role in tissue remodeling related to cardiac function. In earlier studies, MMP-7 A-181G (rs11568818), C-153T (rs11568819), C-115T (rs17886546), and TIMP-2 G-418C (rs8179090) polymorphisms have been studied in various diseases. However, association between coronary artery disease (CAD) and these polymorphisms has been poorly studied. The goal of this study is to investigate the association of CAD and myocardial infarction (MI) with MMP-7 or TIMP-2 polymorphisms...
February 2017: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/28044300/a-mimicker-of-gallbladder-carcinoma-cystic-gastric-heterotopia-with-intestinal-metaplasia
#5
Gonca Özgün, Şaduman Balaban Adim, Nesrin Uğraş, Sadık Kiliçturgay
Heterotopic gastric mucosa in the gallbladder is an unusual entity and is usually clinically silent. We report a 75-year-old female patient who presented with intermittent upper abdomial pain radiating to the back. Abdominal imaging studies showed a sessile polypoid lesion and a gallstone in the gallbladder. Gallbladder carcinoma was suspected and cholecystectomy performed. Intraoperative frozen section examination suggested mucinous tumor, suspicious for malignancy. However, the permanent sections revealed aberrant gastric tissue consisted of gastric pyloric and fundic glands of heterotopic gastric mucosa with intestinal metaplasia in the gallbladder...
2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/27966324/the-effect-of-pneumoperitoneum-on-intravascular-fibrinolytic-activity-in-rats
#6
Kürşat Dikmen, Asiye Uğraş Dikmen, Hasan Bostancı, Ahmet Karamercan, Münci Yağcı, Murat Akın, Bülent Aytaç
BACKGROUND/AIM: Venous stasis during pneumoperitoneum in laparoscopic surgery is closely related to fibrin synthesis and deposition. The etiologic factors underlying fibrinolysis or hypercoagulability are not clearly defined. This study aimed to determine the effects of pneumoperitoneum time and pressure on coagulation cascade and the fibrinolytic pathway. MATERIALS AND METHODS: After the pneumoperitoneum model was established in rats, PAI-1, tPA, TAFI, D-dimer, and fibrinogen activities were evaluated in different time periods under different pressures in groups including 6 rats...
November 17, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/27956678/trainee-anaesthetist-diagnosis-of-intraneural-injection-a-study-comparing-b-mode-ultrasound-with-the-fusion-of-b-mode-and-elastography-in-the-soft-embalmed-thiel-cadaver-model
#7
S Munirama, K Zealley, A Schwab, M Columb, G A Corner, R Eisma, G A McLeod
BACKGROUND: The incidence of intraneural injection during trainee anaesthetist ultrasound guided nerve block varies between 16% in experts and up to 35% in trainees. We hypothesized that elastography, an ultrasound-based technology that presents colour images of tissue strain, had the potential to improve trainee diagnosis of intraneural injection during UGRA, when integrated with B-Mode ultrasound onto a single image. METHODS: We recorded 40 median nerve blocks randomly allocated to 0...
December 2016: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/27924056/correction-metformin-impairs-rho-gtpase-signaling-to-induce-apoptosis-in-neuroblastoma-cells-and-inhibits-growth-of-tumors-in-the-xenograft-mouse-model-of-neuroblastoma
#8
Ambrish Kumar, Nadia Al-Sammarraie, Donald J DiPette, Ugra S Singh
No abstract text is available yet for this article.
July 5, 2016: Oncotarget
https://www.readbyqxmd.com/read/27668899/report-of-data-on-children-with-non-typhi-salmonella-gastroenteritis-in-a-three-year-period
#9
Öznur Küçük, Suat Biçer, Meltem Ugraş, Defne Çöl, Tuba Giray, Gülay Çiler Erdag, Yeşim Gürol, Gülden Yilmaz, Zerrin Yalvaç, Ayça Vitrinel, Çigdem Kaspar
The purpose of this study was to evaluate the clinical and laboratory data of children with acute gastroenteritis caused by non-typhoid Salmonella spp. infections. Clinical (demographic data, symptoms and findings) and laboratory data (stool microscopy, rapid antigen tests, culture, multiplex polymerase chain reaction and blood test results) of children with acute gastroenteritis caused by non-typhoid Salmonella spp. between January 2010 and October 2012 were evaluated. Differences between the groups for categorical variables were estimated with a chi-square or Fisher exact test; for continuous variables with two independent samples a t test was used...
September 1, 2016: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/27569073/immunohistochemical-expression-of-human-epidermal-growth-factor-receptor-her-4-and-prognosis-in-patients-with-metastatic-breast-cancer
#10
Adem Deligonul, Turkkan Evrensel, Nilufer Avci, Nesrin Ugras, Mehmet Ture, Erdem Cubukcu, Mustafa Hartavi, Omer Fatih Olmez, Ender Kurt, Sahsine Tolunay, Ozkan Kanat, Osman Manavoglu
PURPOSE: The clinical value of HER4 - a cell surface receptor that belongs to the human epidermal growth factor receptor family - for predicting survival outcomes in patients with breast cancer remains controversial. Herein, we sought to investigate the prognostic significance of HER4 immunohistochemical expression with respect to progression-free survival (PFS) and overall survival (OS) in Turkish patients with metastatic breast cancer (MBC). METHODS: MBC patients (N=45; mean age=50...
May 2016: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/27501723/erratum-to-conformational-changes-and-translocation-of-tissue-transglutaminase-to-the-plasma-membranes-role-in-cancer-cell-migration
#11
Ambrish Kumar, Jianjun Hu, Holly A LaVoie, Kenneth B Walsh, Donald J DiPette, Ugra S Singh
No abstract text is available yet for this article.
2016: BMC Cancer
https://www.readbyqxmd.com/read/27450024/retrospective-analysis-of-clinicopathological-features-of-solid-pseudopapillary-neoplasm-of-the-pancreas
#12
Nesrin Ugras, Ömer Yerci, Sinem Kantarcıoğlu Coşkun, Gökhan Ocakoğlu, Pınar Sarkut, Halit Ziya Dündar
Solid pseudopapillary neoplasm (SPN) of the pancreas is a rare neoplasm that accounts for 2-3% of all primary pancreatic neoplasms. This study aimed to characterize clinicopathological features associated with SPNs and to retrospectively evaluate the relationship of these features with predictive parameters associated with aggressive behavior. We reviewed 16 cases of SPN of the pancreas that had been diagnosed between 2005 and 2014 at our pathology department. A total of 16 cases, 15 female and one male, were evaluated in this study...
July 2016: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/27408512/is-there-a-treatment-protocol-in-which-platelet-rich-plasma-is-effective
#13
Ibrahim Yilmaz, Semih Akkaya, Mehmet Isyar, Ahmet Güray Batmaz, Olcay Guler, Kadir Oznam, Akin Ugras, Mahir Mahiroğullari
AIM: We aimed to reveal whether there are prospective suggestions for effective and standard platelet-rich plasma applications. METHODS: We searched for clinical trials and traced all the references of incorporated documents. RESULTS: In literature, there was no study indicating which disease is treated by which mechanism of action, how much dose and content are prepared and applied, when the treatment is applied and how many cures are applied...
December 2016: Journal of Orthopaedics
https://www.readbyqxmd.com/read/27396806/do-ultrasound-guided-regional-blocks-signify-a-new-paradigm-in-high-risk-patients
#14
REVIEW
Thomas F Bendtsen, Stephen Haskins, Jens Aage Kølsen Petersen, Jens Børglum
It has been suggested for many years that regional anaesthesia is advantageous in high-risk patients, either as the sole anaesthetic or in combination with general anaesthesia. Regional techniques are safe and even more so when guided by ultrasound. In the high-risk patient population, ultrasound-guided regional anaesthesia (UGRA) can help decrease risk of perioperative morbidity and improve short-term as well as long-term outcomes, particularly in the orthopaedic, vascular, oncologic and chronic pain patient populations...
June 2016: Best Practice & Research. Clinical Anaesthesiology
https://www.readbyqxmd.com/read/27384668/correction-sparstolonin-b-a-novel-plant-derived-compound-arrests-cell-cycle-and-induces-apoptosis-in-n-myc-amplified-and-n-myc-nonamplified-neuroblastoma-cells
#15
Ambrish Kumar, Daping Fan, Donald J DiPette, Ugra S Singh
[This corrects the article DOI: 10.1371/journal.pone.0096343.].
2016: PloS One
https://www.readbyqxmd.com/read/27363505/assessing-the-negative-impact-of-phenyl-alkanoic-acid-derivative-a-frequently-prescribed-drug-for-the-suppression-of-pain-and-inflammation-on-the-differentiation-and-proliferation-of-chondrocytes
#16
Seyit Ali Gumustas, İbrahim Yilmaz, Mehmet Isyar, Duygu Yasar Sirin, Ahmet Guray Batmaz, Ali Akin Ugras, Kadir Oznam, Zafer Ciftci, Mahir Mahirogullari
BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs) are frequently prescribed to relieve pain and inflammation. These NSAIDs have also analgesic effects and can be administered via oral, injectable, and topical routes. During inflammation, a number of synovial mediators and cytokines are released which decrease the pH level of the synovial fluid. Administration of acidic NSAIDs further decreases the pH levels and hence contributes to the destruction of the cartilage. To our knowledge, no cellular-based study regarding the chondrotoxicity of phenyl alkanoic acid derivatives on NSAIDs was conducted before...
June 30, 2016: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/27340517/effects-of-systemic-and-local-interferon-beta-1a-on-epidural-fibrosis
#17
Mevlüt Özgür Taşkapılıoğlu, Semra Işık, Şeref Doğan, Gonca Özgün, Gökhan Ocakoğlu, Nesrin Uğraş
STUDY DESIGN: Level 1 randomized controlled study. PURPOSE: To investigate the effects of systemic and local interferon-beta-1a (IFN-β-1a) on prevention of epidural fibrosis using histopathological parameters. OVERVIEW OF LITERATURE: Epidural fibrosis involves fibroblastic invasion of nerve roots into the epidural space. Formation of dense fibrous tissue causes lumbar and radicular pain. Many surgical techniques and several materials have been proposed in the literature, but no study has assessed the effect of IFN-β-1a on prevention of epidural fibrosis...
June 2016: Asian Spine Journal
https://www.readbyqxmd.com/read/27256640/impact-of-3-utr-variation-patterns-of-the-kras-gene-on-the-aggressiveness-of-pancreatobiliary-tumors-with-the-kras-g13d-mutation-in-a-turkish-population
#18
Unal Egeli, Secil Ak, Gulsah Cecener, Berrin Tunca, Gulcin Tezcan, Elif Demirdogen Sevinc, Ekrem Kaya, Halit Ziya Dundar, Pinar Sarkut, Yilmaz Ozen, Ozkan Balcin, Turkkan Evrensel, Omer Yerci, Nesrin Ugras
OBJECTIVE: Several studies have demonstrated the importance of mutations in codons 12, 13 and 61 and variations in the 3' untranslated region (3'UTR) of the KRAS gene, frequently observed genetic events in the progression of pancreatobiliary tumors (PBT). However, limited data exist on the clinical effect of these alterations. The aim of the current study was to clarify the frequency of relevant alterations of the 3'UTR regions of the KRAS gene and the effect of KRAS 3'UTR polymorphisms on the prognosis of patients with codon 12, 13 and 61 mutations in a Turkish population with PBT...
July 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/27101576/mir-216b-targets-fgfr1-and-confers-sensitivity-to-radiotherapy-in-pancreatic-ductal-adenocarcinoma-patients-without-egfr-or-kras-mutation
#19
Unal Egeli, Gulcin Tezcan, Gulsah Cecener, Berrin Tunca, Elif Demirdogen Sevinc, Ekrem Kaya, Secil Ak, Halit Ziya Dundar, Pinar Sarkut, Nesrin Ugras, Omer Yerci, Yilmaz Ozen, Turkkan Evrensel
OBJECTIVES: The success of gemcitabine plus radiotherapy is dependent on the mutation status of pancreatic ductal adenocarcinoma (PDAC) tumors in the EGFR and KRAS genes; however, radiotherapy resistance may also be modulated epigenetically by microRNA (miRNA) regulation. In this study, we examined the potential effect of miRNAs on the resistance to radiotherapy in cases without EGFR or KRAS mutation. METHODS: The association of EGFR and KRAS mutation status and different expression patterns of 6 selected miRNAs related to the EGFR/KRAS signaling pathway were evaluated in the tumors of 42 patients with PDAC...
October 2016: Pancreas
https://www.readbyqxmd.com/read/27039793/determination-of-patient-learning-needs-after-thyroidectomy
#20
Zeynep Temiz, Didem Ozturk, Gulay Altun Ugras, Seher Deniz Oztekin, Emel Sengul
The purpose of this study was to determine discharge learning needs of patients undergoing thyroidectomy. The population of this descriptive study consisted of patients undergoing thyroidectomy in the Endocrine Surgery Unit of a university hospital between February and December 2013. The study included 251 patients who were discharged after thyroidectomy. Data obtained using the data collection form and the Patient Leaning Needs Scale (PLNS) were analyzed by frequency, mean, standard deviation, Kruskal Wallis and student-t tests...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
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