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https://www.readbyqxmd.com/read/27668899/report-of-data-on-children-with-non-typhi-salmonella-gastroenteritis-in-a-three-year-period
#1
Öznur Küçük, Suat Biçer, Meltem Ugraş, Defne Çöl, Tuba Giray, Gülay Çiler Erdag, Yeşim Gürol, Gülden Yilmaz, Zerrin Yalvaç, Ayça Vitrinel, Çigdem Kaspar
The purpose of this study was to evaluate the clinical and laboratory data of children with acute gastroenteritis caused by non-typhoid Salmonella spp. infections. Clinical (demographic data, symptoms and findings) and laboratory data (stool microscopy, rapid antigen tests, culture, multiplex polymerase chain reaction and blood test results) of children with acute gastroenteritis caused by non-typhoid Salmonella spp. between January 2010 and October 2012 were evaluated. Differences between the groups for categorical variables were estimated with a chi-square or Fisher exact test; for continuous variables with two independent samples a t test was used...
September 1, 2016: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/27569073/immunohistochemical-expression-of-human-epidermal-growth-factor-receptor-her-4-and-prognosis-in-patients-with-metastatic-breast-cancer
#2
Adem Deligonul, Turkkan Evrensel, Nilufer Avci, Nesrin Ugras, Mehmet Ture, Erdem Cubukcu, Mustafa Hartavi, Omer Fatih Olmez, Ender Kurt, Sahsine Tolunay, Ozkan Kanat, Osman Manavoglu
PURPOSE: The clinical value of HER4 - a cell surface receptor that belongs to the human epidermal growth factor receptor family - for predicting survival outcomes in patients with breast cancer remains controversial. Herein, we sought to investigate the prognostic significance of HER4 immunohistochemical expression with respect to progression-free survival (PFS) and overall survival (OS) in Turkish patients with metastatic breast cancer (MBC). METHODS: MBC patients (N=45; mean age=50...
May 2016: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/27501723/erratum-to-conformational-changes-and-translocation-of-tissue-transglutaminase-to-the-plasma-membranes-role-in-cancer-cell-migration
#3
Ambrish Kumar, Jianjun Hu, Holly A LaVoie, Kenneth B Walsh, Donald J DiPette, Ugra S Singh
No abstract text is available yet for this article.
2016: BMC Cancer
https://www.readbyqxmd.com/read/27450024/retrospective-analysis-of-clinicopathological-features-of-solid-pseudopapillary-neoplasm-of-the-pancreas
#4
Nesrin Ugras, Ömer Yerci, Sinem Kantarcıoğlu Coşkun, Gökhan Ocakoğlu, Pınar Sarkut, Halit Ziya Dündar
Solid pseudopapillary neoplasm (SPN) of the pancreas is a rare neoplasm that accounts for 2-3% of all primary pancreatic neoplasms. This study aimed to characterize clinicopathological features associated with SPNs and to retrospectively evaluate the relationship of these features with predictive parameters associated with aggressive behavior. We reviewed 16 cases of SPN of the pancreas that had been diagnosed between 2005 and 2014 at our pathology department. A total of 16 cases, 15 female and one male, were evaluated in this study...
July 2016: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/27408512/is-there-a-treatment-protocol-in-which-platelet-rich-plasma-is-effective
#5
Ibrahim Yilmaz, Semih Akkaya, Mehmet Isyar, Ahmet Güray Batmaz, Olcay Guler, Kadir Oznam, Akin Ugras, Mahir Mahiroğullari
AIM: We aimed to reveal whether there are prospective suggestions for effective and standard platelet-rich plasma applications. METHODS: We searched for clinical trials and traced all the references of incorporated documents. RESULTS: In literature, there was no study indicating which disease is treated by which mechanism of action, how much dose and content are prepared and applied, when the treatment is applied and how many cures are applied...
December 2016: Journal of Orthopaedics
https://www.readbyqxmd.com/read/27396806/do-ultrasound-guided-regional-blocks-signify-a-new-paradigm-in-high-risk-patients
#6
REVIEW
Thomas F Bendtsen, Stephen Haskins, Jens Aage Kølsen Petersen, Jens Børglum
It has been suggested for many years that regional anaesthesia is advantageous in high-risk patients, either as the sole anaesthetic or in combination with general anaesthesia. Regional techniques are safe and even more so when guided by ultrasound. In the high-risk patient population, ultrasound-guided regional anaesthesia (UGRA) can help decrease risk of perioperative morbidity and improve short-term as well as long-term outcomes, particularly in the orthopaedic, vascular, oncologic and chronic pain patient populations...
June 2016: Best Practice & Research. Clinical Anaesthesiology
https://www.readbyqxmd.com/read/27384668/correction-sparstolonin-b-a-novel-plant-derived-compound-arrests-cell-cycle-and-induces-apoptosis-in-n-myc-amplified-and-n-myc-nonamplified-neuroblastoma-cells
#7
Ambrish Kumar, Daping Fan, Donald J DiPette, Ugra S Singh
[This corrects the article DOI: 10.1371/journal.pone.0096343.].
2016: PloS One
https://www.readbyqxmd.com/read/27363505/assessing-the-negative-impact-of-phenyl-alkanoic-acid-derivative-a-frequently-prescribed-drug-for-the-suppression-of-pain-and-inflammation-on-the-differentiation-and-proliferation-of-chondrocytes
#8
Seyit Ali Gumustas, İbrahim Yilmaz, Mehmet Isyar, Duygu Yasar Sirin, Ahmet Guray Batmaz, Ali Akin Ugras, Kadir Oznam, Zafer Ciftci, Mahir Mahirogullari
BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs) are frequently prescribed to relieve pain and inflammation. These NSAIDs have also analgesic effects and can be administered via oral, injectable, and topical routes. During inflammation, a number of synovial mediators and cytokines are released which decrease the pH level of the synovial fluid. Administration of acidic NSAIDs further decreases the pH levels and hence contributes to the destruction of the cartilage. To our knowledge, no cellular-based study regarding the chondrotoxicity of phenyl alkanoic acid derivatives on NSAIDs was conducted before...
2016: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/27340517/effects-of-systemic-and-local-interferon-beta-1a-on-epidural-fibrosis
#9
Mevlüt Özgür Taşkapılıoğlu, Semra Işık, Şeref Doğan, Gonca Özgün, Gökhan Ocakoğlu, Nesrin Uğraş
STUDY DESIGN: Level 1 randomized controlled study. PURPOSE: To investigate the effects of systemic and local interferon-beta-1a (IFN-β-1a) on prevention of epidural fibrosis using histopathological parameters. OVERVIEW OF LITERATURE: Epidural fibrosis involves fibroblastic invasion of nerve roots into the epidural space. Formation of dense fibrous tissue causes lumbar and radicular pain. Many surgical techniques and several materials have been proposed in the literature, but no study has assessed the effect of IFN-β-1a on prevention of epidural fibrosis...
June 2016: Asian Spine Journal
https://www.readbyqxmd.com/read/27256640/impact-of-3-utr-variation-patterns-of-the-kras-gene-on-the-aggressiveness-of-pancreatobiliary-tumors-with-the-kras-g13d-mutation-in-a-turkish-population
#10
Unal Egeli, Secil Ak, Gulsah Cecener, Berrin Tunca, Gulcin Tezcan, Elif Demirdogen Sevinc, Ekrem Kaya, Halit Ziya Dundar, Pinar Sarkut, Yilmaz Ozen, Ozkan Balcin, Turkkan Evrensel, Omer Yerci, Nesrin Ugras
OBJECTIVE: Several studies have demonstrated the importance of mutations in codons 12, 13 and 61 and variations in the 3' untranslated region (3'UTR) of the KRAS gene, frequently observed genetic events in the progression of pancreatobiliary tumors (PBT). However, limited data exist on the clinical effect of these alterations. The aim of the current study was to clarify the frequency of relevant alterations of the 3'UTR regions of the KRAS gene and the effect of KRAS 3'UTR polymorphisms on the prognosis of patients with codon 12, 13 and 61 mutations in a Turkish population with PBT...
July 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/27101576/mir-216b-targets-fgfr1-and-confers-sensitivity-to-radiotherapy-in-pancreatic-ductal-adenocarcinoma-patients-without-egfr-or-kras-mutation
#11
Unal Egeli, Gulcin Tezcan, Gulsah Cecener, Berrin Tunca, Elif Demirdogen Sevinc, Ekrem Kaya, Secil Ak, Halit Ziya Dundar, Pinar Sarkut, Nesrin Ugras, Omer Yerci, Yilmaz Ozen, Turkkan Evrensel
OBJECTIVES: The success of gemcitabine plus radiotherapy is dependent on the mutation status of pancreatic ductal adenocarcinoma (PDAC) tumors in the EGFR and KRAS genes; however, radiotherapy resistance may also be modulated epigenetically by microRNA (miRNA) regulation. In this study, we examined the potential effect of miRNAs on the resistance to radiotherapy in cases without EGFR or KRAS mutation. METHODS: The association of EGFR and KRAS mutation status and different expression patterns of 6 selected miRNAs related to the EGFR/KRAS signaling pathway were evaluated in the tumors of 42 patients with PDAC...
October 2016: Pancreas
https://www.readbyqxmd.com/read/27039793/determination-of-patient-learning-needs-after-thyroidectomy
#12
Zeynep Temiz, Didem Ozturk, Gulay Altun Ugras, Seher Deniz Oztekin, Emel Sengul
The purpose of this study was to determine discharge learning needs of patients undergoing thyroidectomy. The population of this descriptive study consisted of patients undergoing thyroidectomy in the Endocrine Surgery Unit of a university hospital between February and December 2013. The study included 251 patients who were discharged after thyroidectomy. Data obtained using the data collection form and the Patient Leaning Needs Scale (PLNS) were analyzed by frequency, mean, standard deviation, Kruskal Wallis and student-t tests...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27031894/hypertransaminasaemia-in-children-with-viral-gastroenteritis
#13
Oznur Kucuk, Meltem Ugras, Suat Bicer, Defne Col, Tuba Giray, Gulay Ciler Erdag, Zerrin Yalvaç, Cigdem Kaspar, Ayca Vitrinel
We investigated the rates of increase in serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels of patients with rotavirus, norovirus and enteric adenovirus gastroenteritis. Two hundred children with viral gastroenteritis were evaluated for hypertransaminasaemia retrospectively. The patients were between 0 - 17 years (mean ± SD: 5.10 ± 3.01) of age. ALT was elevated up to 67 IU/L in 7 (8.5%) patients in the rotavirus group (n=82), whereas it was elevated in 3 (4.0%) and 1 (2.3%) patients in the norovirus (n=74) and adenovirus (n=44) groups, respectively...
2016: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/27003771/prognostic-value-of-p53-protein-expression-in-giant-cell-tumor-of-bone
#14
Ulviye Yalcinkaya, Nesrin Ugras, Selva Kabul, Gokhan Ocakoglu, Muhammed S Bilgen
Giant cell tumor of bone (GCTB) is a benign tumor with a tendency for local recurrence. GCTB may cause lung metastases, and secondary malignant GCTB is rare. Its histological appearance does not predict local aggressiveness and/or the metastatic potential of the tumor. We aimed to investigate the prognostic value of the Ki-67 proliferative index and p53 protein expression in GCTB in predicting local recurrence, lung metastasis, and malignant transformation. We retrospectively reviewed 42 cases of GCTB. The p53 expression was positive in 20 cases...
December 2015: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/26980475/feasibility-of-eye-tracking-technology-to-quantify-expertise-in-ultrasound-guided-regional-anesthesia
#15
T Kyle Harrison, T Edward Kim, Alex Kou, Cynthia Shum, Edward R Mariano, Steven K Howard
Ultrasound-guided regional anesthesia (UGRA) requires an advanced procedural skill set that incorporates both sonographic knowledge of relevant anatomy as well as technical proficiency in needle manipulation in order to achieve a successful outcome. Understanding how to differentiate a novice from an expert in UGRA using a quantifiable tool may be useful for comparing educational interventions that could improve the rate at which one develops expertise. Exploring the gaze pattern of individuals performing a task has been used to evaluate expertise in many different disciplines, including medicine...
June 2016: Journal of Anesthesia
https://www.readbyqxmd.com/read/26866296/comparative-effectiveness-of-simulation-based-deliberate-practice-versus-self-guided-practice-on-resident-anesthesiologists-acquisition-of-ultrasound-guided-regional-anesthesia-skills
#16
Ankeet Deepak Udani, T Kyle Harrison, Edward R Mariano, Ryan Derby, Jack Kan, Toni Ganaway, Cynthia Shum, David M Gaba, Pedro Tanaka, Alex Kou, Steven K Howard
BACKGROUND AND OBJECTIVES: Simulation-based education strategies to teach regional anesthesia have been described, but their efficacy largely has been assumed. We designed this study to determine whether residents trained using the simulation-based strategy of deliberate practice show greater improvement of ultrasound-guided regional anesthesia (UGRA) skills than residents trained using self-guided practice in simulation. METHODS: Anesthesiology residents new to UGRA were randomized to participate in either simulation-based deliberate practice (intervention) or self-guided practice (control)...
March 2016: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/26860837/teaching-ultrasound-guided-regional-anesthesia-remotely-a-feasibility-study
#17
D A Burckett-St Laurent, M S Cunningham, S Abbas, V W Chan, A Okrainec, A U Niazi
BACKGROUND: Ultrasound-guided regional anesthesia (UGRA) requires acquisition of new skills. Learning requires one-on-one teaching, and can be limited by time and mentor availability. We investigate whether the skills required for UGRA can be developed and subsequently assessed remotely using a novel online teaching platform. This platform was developed at the University of Toronto to teach laparoscopic surgery remotely and has been termed Telesimulation. METHODS: Anesthesia Site Chiefs at 10 hospitals across Ontario were sent a letter inviting their anesthesia teams to participate in an UGRA remote training program...
August 2016: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/26857098/diagnostic-value-of-sonography-for-detecting-endometrial-pathologies-in-postmenopausal-women-with-and-without-bleeding
#18
Berna Seckin, Mahmut Nedim Cicek, Asiye Ugras Dikmen, Esra Isci Bostancı, Kamil Hakan Muftuoglu
PURPOSE: To investigate the diagnostic value of endometrial thickness measurement on sonography in predicting endometrial pathologies in postmenopausal women with vaginal bleeding and in those with asymptomatic thickened endometrium. METHODS: Six hundred two postmenopausal women with vaginal bleeding or asymptomatic thickened endometrium were evaluated in this study. Two hundred seventy-four women with postmenopausal bleeding regardless of endometrial thickness (group 1: symptomatic) and 328 women with an incidental finding of thickened endometrium (≥5 mm) without bleeding (group 2: asymptomatic) underwent endometrial biopsy for histopathologic examination...
July 8, 2016: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/26747212/dynamic-structural-flexibility-of-%C3%AE-synuclein
#19
REVIEW
Danielle E Mor, Scott E Ugras, Malcolm J Daniels, Harry Ischiropoulos
α-Synuclein is a conserved, abundantly expressed protein that is partially localized in pre-synaptic terminals in the central nervous system. The precise biological function(s) and structure of α-synuclein are under investigation. Recently, the native conformation and the presence of naturally occurring multimeric assemblies have come under debate. These are important deliberations because α-synuclein assembles into highly organized amyloid-like fibrils and non-amyloid amorphous aggregates that constitute the neuronal inclusions in Parkinson's disease and related disorders...
April 2016: Neurobiology of Disease
https://www.readbyqxmd.com/read/26644258/reoperative-sentinel-lymph-node-biopsy-is-feasible-for-locally-recurrent-breast-cancer-but-is-it-worthwhile
#20
Stacy Ugras, Cindy Matsen, Anne Eaton, Michelle Stempel, Monica Morrow, Hiram S Cody
INTRODUCTION: Reoperative sentinel lymph node biopsy (SLNB) is feasible in patients with local recurrence (LR) of invasive breast cancer but it remains unclear if this procedure affects either treatment or outcome. In this study, we ask whether axillary restaging (vs. none) at the time of LR affects the rate of subsequent events: axillary failure (AF), non-axillary recurrence (NAR), distant metastasis, or death. METHODS: We queried our institutional database to identify patients treated surgically for invasive breast cancer with a negative SLNB (1997-2000) who developed ipsilateral breast or chest wall recurrence as a first event...
March 2016: Annals of Surgical Oncology
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