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https://www.readbyqxmd.com/read/29759483/induction-of-the-immunoproteasome-subunit-lmp7-links-proteostasis-and-immunity-in-%C3%AE-synuclein-aggregation-disorders
#1
Scott Ugras, Malcolm J Daniels, Hossein Fazelinia, Neal S Gould, Anastasia K Yocum, Kelvin C Luk, Esteban Luna, Hua Ding, Chris McKennan, Steven Seeholzer, Dan Martinez, Perry Evans, Daniel Brown, John E Duda, Harry Ischiropoulos
Accumulation of aggregated α-synuclein into Lewy bodies is thought to contribute to the onset and progression of dopaminergic neuron degeneration in Parkinson's disease (PD) and related disorders. Although protein aggregation is associated with perturbation of proteostasis, how α-synuclein aggregation affects the brain proteome and signaling remains uncertain. In a mouse model of α-synuclein aggregation, 6% of 6215 proteins and 1.6% of 8183 phosphopeptides changed in abundance, indicating conservation of proteostasis and phosphorylation signaling...
May 11, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29728240/adaptive-median-binary-patterns-for-fully-automatic-nerves-tracking-in-ultrasound-images
#2
Mohammad Alkhatib, Adel Hafiane, Omar Tahri, Pierre Vieyres, Alain Delbos
BACKGROUND AND OBJECTIVE: In the last decade, Ultrasound-Guided Regional Anesthesia (UGRA) gained importance in surgical procedures and pain management, due to its ability to perform target delivery of local anesthetics under direct sonographic visualization. However, practicing UGRA can be challenging, since it requires high skilled and experienced operator. Among the difficult task that the operator can face, is the tracking of the nerve structure in ultrasound images. Tracking task in US images is very challenging due to the noise and other artifacts...
July 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29705448/the-effect-of-different-types-of-music-on-patients-preoperative-anxiety-a-randomized-controlled-trial
#3
Gülay Altun Uğraş, Güven Yıldırım, Serpil Yüksel, Yusuf Öztürkçü, Mustafa Kuzdere, Seher Deniz Öztekin
OBJECTIVE: The purpose of this study was to determine effect of three different types of music on patients' preoperative anxiety. METHOD: This randomized controlled trial included 180 patients who were randomly divided into four groups. While the control group didn't listen to music, the experimental groups respectively listened to natural sounds, Classical Turkish or Western Music for 30 min. The State Anxiety Inventory (STAI-S), systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR) and cortisol levels were checked...
May 2018: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/29700912/coexistence-of-macc1-and-nm23-h1-dysregulation-and-tumor-budding-promise-early-prognostic-evidence-for-recurrence-risk-of-early-stage-colon-cancer
#4
Ersin Ozturk, Secil Ak Aksoy, Nesrin Ugras, Berrin Tunca, Serkan Ceylan, Gulcin Tezcan, Tuncay Yilmazlar, Omer Yerci, Unal Egeli, Gulsah Cecener
The tumor-node-metastasis (TNM) classification, the presence of a mucinous component, and signet ring cells are well-known criteria for identifying patients at a high risk for recurrence and determining the therapeutic approach for early-stage colon cancer (eCC). Nevertheless, recurrence can unexpectedly occur in some eCC cases after surgical resection. The aims of the present study were to evaluate the relation of dysregulated MACC1, c-MET, and NM23-H1 expression with the histopathological features of tumors in recurrence formation in eCC cases...
February 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/29687783/subnormal-growth-velocity-and-related-factors-during-gnrh-analog-therapy-for-idiopathic-central-precocious-puberty
#5
Nursel Muratoğlu Şahin, Asiye Uğraş Dikmen, Semra Çetinkaya, Zehra Aycan
OBJECTIVE: Decline of subnormal growth velocity(GV) and related factors during gonadotropin-releasing hormone analog(GnRHa) therapy for idiopathic central precocious puberty(ICPP) are unclear. We investigated the incidence of subnormal growth velocity, associated factors in patients with GnRHa therapy for ICPP. METHODS: In this retrospective cohort study, the records of 50 girls were investigated, who had diagnosed ICPP and had started GnRHa treatment before the age of 8...
April 24, 2018: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/29644919/high-neutrophil-lymphocyte-ratio-in-schizophrenia-independent-of-infectious-and-metabolic-parameters
#6
Rabia Nazik Yüksel, Irem Ekmekci Ertek, Asiye Uğraş Dikmen, Erol Göka
BACKGROUND: Immunological and inflammatory mechanisms play an important role in schizophrenia. In the literature, there are studies investigating neutrophil-lymphocyte ratio (NLR) association with schizophrenia. AIMS: The purpose of this study was to compare NLR values between patients with schizophrenia and healthy controls. In addition, the study aimed to investigate the relationship between NLR and disease severity and some metabolic/inflammatory parameters. METHODS: Fifty-two patients diagnosed with schzophrenia and 53 healthy controls were included in the study...
April 12, 2018: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/29537318/pregnancy-outcomes-after-suicide-attempts-by-self-poisoning-and-drug-overdose-experience-of-a-clinical-pharmacology-consultation-service-in-izmir-turkey
#7
Zeynep Ozturk, Kadriye Ugras
No abstract text is available yet for this article.
March 14, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29446580/is-there-any-difference-between-the-symptomatology-and-clinical-findings-of-viral-agents-causing-dehydration
#8
Suat Biçer, Defne Çöl, Öznur Küçük, Gülay Ç Erdağ, Tuba Giray, Meltem Uğraş, Ayça Vitrinel, Çiğdem Kaspar
BACKGROUND: Acute gastroenteritis is responsible for dehydration in many children. The viruses like rotavirus, norovirus, and adenovirus are considered the main causative agents of gastroenteritis. The goal of this study is the evaluation of the symptoms, clinical findings and hospitalization requirements in pediatric patients with dehydration secondary to viral gastroenteritis. METHODS: The distribution of age, symptoms, clinical and laboratory findings and hospitalization requirements of 156 viral acute gastroenteritis patients with moderate dehydration were evaluated retrospectively...
April 2018: Minerva Pediatrica
https://www.readbyqxmd.com/read/29428912/survival-of-children-living-with-human-immunodeficiency-virus-on-antiretroviral-therapy-in-andhra-pradesh-india
#9
Ugra Mohan Jha, Neeraj Dhingra, Yujwal Raj Jones, Bharat Bhusan Rewari, L Jeyaseelan, Pauline Harvey, Laxmikant Chavan, Niranjan Saggurti, D C S Reddy
OBJECTIVE: To assess the survival probability and associated factors among children living with human immunodeficiency virus (CLHIV) receiving antiretroviral therapy (ART) in India. METHODS: The data on 5874 children (55% boys) from one of the high HIV burden states of India from the cohort were analyzed. Data were extracted from the computerized management information system of the National AIDS Control Organization (NACO). Children were eligible for inclusion if they had started ART during 2007-2013, and had at least one potential follow-up...
February 9, 2018: Indian Pediatrics
https://www.readbyqxmd.com/read/29329159/overexpression-of-the-long-noncoding-rna-homeoboxa-transcript-at-the-distal-tip-predicts-poor-prognosis-in-a-kras-independent-manner-in-periampullary-region-tumors
#10
Ozkan Balcin, Secil Ak Aksoy, Berrin Tunca, Ekrem Kaya, Unal Egeli, Gulcin Tezcan, Nesrin Ugras, Gulsah Cecener, Ozgen Isik, Halit Ziya Dundar, Omer Yerci
OBJECTIVES: Periampullary region tumors (PRTs) are the fifth highest cause of cancer-related deaths worldwide. Although recent studies have highlighted the prognostic value of the long noncoding RNA HomeoboxA transcript at the distal tip (HOTTIP) in patients with pancreatic ductal adenocarcinoma, the relationship between HOTTIP and clinical outcome of all PRTs remains obscure. The aim of this study was to clarify the prognostic significance of HOTTIP in patients with all PRTs related to KRAS mutational status...
February 2018: Pancreas
https://www.readbyqxmd.com/read/29168464/sustained-progress-but-no-room-for-complacency-results-of-2015-hiv-estimations-in-india
#11
Arvind Pandey, Neeraj Dhingra, Pradeep Kumar, Damodar Sahu, D C S Reddy, Padum Narayan, Yujwal Raj, Bhavna Sangal, Nalini Chandra, Saritha Nair, Jitenkumar Singh, Laxmikant Chavan, Deepika Joshi Srivastava, Ugra Mohan Jha, Vinita Verma, Shashi Kant, Madhulekha Bhattacharya, Pushpanjali Swain, Partha Haldar, Lucky Singh, Taoufik Bakkali, John Stover, Savina Ammassari
BACKGROUND & OBJECTIVES: Evidence-based planning has been the cornerstone of India's response to HIV/AIDS. Here we describe the process, method and tools used for generating the 2015 HIV estimates and provide a summary of the main results. METHODS: Spectrum software supported by the UNAIDS was used to produce HIV estimates for India as a whole and its States/Union Territories. This tool takes into consideration the size and HIV prevalence of defined population groups and programme data to estimate HIV prevalence, incidence and mortality over time as well as treatment needs...
July 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28976111/contribution-of-cell-blocks-obtained-through-endobronchial-ultrasound-guided-transbronchial-needle-aspiration-for-the-determination-of-lung-cancer-subtypes
#12
Nilgün Yılmaz Demirci, Asiye Uğraş Dikmen, Zarife Abdullayeva, Can Öztürk
INTRODUCTION: It is crucial to diagnose the subtype of lung cancer quickly and accurately for effective therapy. Conventional cytology staining sometimes provides limited information, and additional tissue is often required to diagnose lung cancer. Cell blocks (CB) recovered during endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) increases the diagnostic accuracy of the procedure and the likelihood of additional valuable histochemical and immunohistochemical staining...
October 4, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28759501/ultrasound-guided-regional-anesthesia-simulation-training-a-systematic-review
#13
Xiao Xu Chen, Vatsal Trivedi, AbdulHadi A AlSaflan, Suzanne Clare Todd, Andrea C Tricco, Colin J L McCartney, Sylvain Boet
BACKGROUND AND OBJECTIVES: Ultrasound-guided regional anesthesia (UGRA) has become the criterion standard of regional anesthesia practice. Ultrasound-guided regional anesthesia teaching programs often use simulation, and guidelines have been published to help guide URGA education. This systematic review aimed to examine the effectiveness of simulation-based education for the acquisition and maintenance of competence in UGRA. METHODS: Studies identified in MEDLINE, EMBASE, CINAHL, Cochrane Central Register of Controlled Trials, and ERIC were included if they assessed simulation-based UGRA teaching with outcomes measured at Kirkpatrick level 2 (knowledge and skills), 3 (transfer of learning to the workplace), or 4 (patient outcomes)...
November 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/28738014/enhancer-of-zeste-homologue-2-ezh2-expression-in-synovial-sarcomas-as-a-promising-indicator-of-prognosis
#14
Ulviye Yalçınkaya, Nesrin Uğraş, Gonca Özgün, Gökhan Ocakoğlu, Adem Deligönül, Sibel Kahraman Çetintaş, Muhammed Sadık Bilgen
Synovial sarcoma (SS) is a type of soft-tissue sarcoma, often linked to poor survival. Although overexpression of enhancer of zeste homologue 2 (EZH2) has been associated with poor prognosis in different tumors, a few studies investigated this link in SS. Here, we analyzed the relationship between EZH2 expression and prognostic factors in SS. We included 29 patients with SS. Immunostaining of EZH2 was performed with (D2C9) XPTM Rabbit mAb antibody, and the results were classified as low EZH2 expression (negative or weak expression) and high EZH2 expression category (moderate or strong expression)...
November 20, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28616620/superior-mesenteric-artery-syndrome-a-rare-but-life-threatening-disease
#15
Meltem Ugras, Suat Bicer, Fatma Tugba Coskun, Endi Romano, Baki Ekci
Superior mesenteric artery syndrome was observed in an adolescent patient. He had a 1-day history of nausea, vomiting, and abdominal pain, without chronic or recurrent symptoms. Diagnosis was established by abdominal plain x-ray, contrast enhanced abdominal computed tomography, and endoscopic examination. The patient was hospitalized, monitorized, and decompressed by nasogastric tube without oral feeding. The symptoms of the patient were gradually relieved by conservative treatment and he was discharged after one week...
June 2017: Turkish Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28580083/implementation-of-clinical-practice-changes-by-experienced-anesthesiologists-after-simulation-based-ultrasound-guided-regional-anesthesia-training
#16
T Edward Kim, Toni Ganaway, T Kyle Harrison, Steven K Howard, Cynthia Shum, Alex Kuo, Edward R Mariano
BACKGROUND: Anesthesiologists who have finished formal training and want to learn ultrasound-guided regional anesthesia (UGRA) commonly attend 1 day workshops. However, it is unclear whether participation actually changes clinical practice. We assessed change implementation after completion of a 1 day simulation-based UGRA workshop. METHODS: Practicing anesthesiologists who participated in a 1 day UGRA course from January 2012 through May 2014 were surveyed. The course consisted of clinical observation of UGRA procedures, didactic lectures, ultrasound scanning, hands-on perineural catheter placement, and mannequin simulation...
June 2017: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/28558201/geochemical-interactions-of-plutonium-with-opalinus-clay-studied-by-spatially-resolved-synchrotron-radiation-techniques
#17
Ugras Kaplan, Samer Amayri, Jakob Drebert, Andre Rossberg, Daniel Grolimund, Tobias Reich
Plutonium plays an important role within nuclear waste materials because of its long half-life and high radiotoxicity. The aim of this study was to investigate with high spatial resolution the reactivity of the more oxidized forms of Pu(V,VI) within Opalinus Clay (OPA) rock, a heterogeneous, natural argillaceous rock considered as a potential repository host. A combination of synchrotron based X-ray microprobe and bulk techniques was used to study the spatial distribution and molecular speciation of Pu within OPA after diffusion and sorption processes...
July 18, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28435816/a-risk-assessment-comparison-of-breast-cancer-and-factors-affected-to-risk-perception-of-women-in-turkey-a-cross-sectional-study
#18
Serpil Yüksel, Gülay Altun Uğraş, İkbal Çavdar, Atilla Bozdoğan, Sibel Özkan Gürdal, Neriman Akyolcu, Ecem Esencan, Gamze Varol Saraçoğlu, Vahit Özmen
BACKGROUND: The increase in breast cancer incidence has enhanced attention towards breast cancer risk. The aim of this study was to determine the risk of breast cancer and risk perception of women, factors that affect risk perception, and to determine differences between absolute risk and the perception of risk. METHODS: This cross-sectional study was carried out among 346 women whose score in the Gail Risk Model (GRM) was ≥ 1.67% and/or had a 1(st) degree relative with breast cancer in Bahçeşehir town in Istanbul, Turkey between Jul 2012 and Dec 2012...
March 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28418350/femoral-adamantinoma-a-rare-lesion-in-an-elderly-patient-in-a-rare-location
#19
Bahattin Kerem Aydın, Zeeshan Khan, Turgay Er, Serdar Uğraş
No abstract text is available yet for this article.
April 5, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28383326/a-new-diagnostic-and-prognostic-marker-in-endometrial-cancer-neopterin
#20
Esra Isci Bostanci, Asiye Ugras Dikmen, Gozde Girgin, Tayfun Gungor, Terken Baydar, Ahmet Nuri Danisman
OBJECTIVE: In this study, we investigated the correlation between serum and urinary neopterin levels as well as the stage of the disease in women with endometrial cancer.Increased neopterin concentrations are reported in patients with activation of macrophages by interferon-γ, which includes the following: viral infections, autoimmune disorders, allograft rejection, and various malignant tumors. In patients with several types of cancer, high-neopterin concentrations in body fluids like serum/plasma, urine, ascites, and cerebrospinal fluid indicate the course of the disease, and it is associated with poor prognosis...
May 2017: International Journal of Gynecological Cancer
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