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Prolotherapy

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https://www.readbyqxmd.com/read/29770163/ultrasound-guided-prolotherapy-with-polydeoxyribonucleotide-for-painful-rotator-cuff-tendinopathy
#1
Kyoungho Ryu, Dongchan Ko, Goeun Lim, Eugene Kim, Sung Hyun Lee
Background: Rotator cuff tendinopathy is a primary cause of shoulder pain and dysfunction. Several effective nonsurgical treatment methods have been described for chronic rotator cuff tendinopathy. Prolotherapy with polydeoxyribonucleotide (PDRN), which consists of active deoxyribonucleotide polymers that stimulate tissue repair, is a nonsurgical regenerative injection that may be a viable treatment option. The objective of this study was to assess the efficacy of PDRN in the treatment of chronic rotator cuff tendinopathy...
2018: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/29764447/efficacy-of-intra-articular-hypertonic-dextrose-prolotherapy-versus-normal-saline-for-knee-osteoarthritis-a-protocol-for-a-triple-blinded-randomized-controlled-trial
#2
Regina Wing Shan Sit, Ricky Wing Keung Wu, Kenneth Dean Reeves, David Rabago, Dicken Cheong Chun Chan, Benjamin Hon Kei Yip, Vincent Chi Ho Chung, Samuel Yeung Shan Wong
BACKGROUND: Knee Osteoarthritis (KOA) is a very common condition with prevalence rising with age. It is a major contributor to global disability and has a large socioeconomic burden worldwide. Conservative therapies have marginal effectiveness, and surgery is reserved for severe symptomatic KOA. Dextrose Prolotherapy (DPT) is an evidence-based injection-based therapy for chronic musculoskeletal conditions including KOA. The standard "whole joint" injection method includes intra-articular injection and multiple extra-articular injections at soft tissue bony attachments...
May 15, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29722769/alternatives-to-biologics-in-management-of-knee-osteoarthritis-a-systematic-review
#3
Fadi Hassan, William D Murrell, Andrew Refalo, Nicola Maffulli
BACKGROUND: Knee osteoarthritis (KOA) is a common condition encountered by physicians. KOA is addressed by a wide array of modalities including a number of nonbiological treatments. METHODS: PubMed, ISI Web of Science, and SPORTDiscus were searched for level 1 to 4 studies published from inception to August 2017. RESULTS: A total of 18 studies were evaluated and results demonstrated moderate supporting evidence for prolotherapy and limited evidence for botulinum toxin type A, sodium bicarbonate and calcium gluconate, and low-molecular weight fraction of 5% human serum albumin...
June 2018: Sports Medicine and Arthroscopy Review
https://www.readbyqxmd.com/read/29696113/prolotherapy-and-low-level-laser-therapy-a-synergistic-approach-to-pain-management-in-chronic-osteoarthritis
#4
REVIEW
Vinicius Tieppo Francio, Robert S Dima, Chris Towery, Saeid Davani
Regenerative injection therapy and low level laser therapy are alternative remedies known for their success in the treatment and symptomatic management of chronic musculoskeletal conditions. In response to the growing demand for alternative therapies in the face of the opioid epidemic, the authors conduct a literature review to investigate the potential for prolotherapy and LLLT to be used adjunctively to manage chronic osteoarthritis (OA). OA is a degenerative chronic musculoskeletal condition on the rise in North America, and is frequently treated with opioid medications...
October 2017: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/29609940/functional-outcome-from-sacroiliac-joint-prolotherapy-in-patients-with-sacroiliac-joint-instability
#5
Martin D Hoffman, Vikram Agnish
OBJECTIVES: Examine the effectiveness of sacroiliac (SI) joint prolotherapy for SI joint instability, and characterize the patients most likely to benefit from this treatment. DESIGN: Retrospective cohort study. SETTING: Department of Veterans Affairs outpatient physical medicine clinic. INTERVENTIONS: Patients referred for low back pain and diagnosed with SI joint instability received a series of three SI joint prolotherapy injections (15% dextrose in lidocaine) at approximately a one-month interval...
April 2018: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/29533255/evaluation-of-the-efficacy-of-different-concentrations-of-dextrose-prolotherapy-in-temporomandibular-joint-hypermobility-treatment
#6
Rawand Mustafa, Metin Güngörmüş, Nur Mollaoğlu
PURPOSE: The aim of this study was to compare and evaluate the efficacy of different concentrations of dextrose prolotherapy for the treatment of temporomandibular joint (TMJ) hypermobility. PATIENTS AND METHODS: A prospective, randomized clinical trial including patients with subluxation or dislocation was performed. The study comprised 40 patients. Patients were randomly divided into 4 groups: control group, 10% dextrose, 20% dextrose, and 30% dextrose group. Patients in all groups received injections into 4 different areas of each TMJ in 4 sessions at monthly intervals...
March 12, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29499824/injection-therapies-for-rotator-cuff-disease
#7
REVIEW
Kenneth M Lin, Dean Wang, Joshua S Dines
Rotator cuff disease affects a large proportion of the overall population and encompasses a wide spectrum of pathologies, including subacromial impingement, rotator cuff tendinopathy or tear, and calcific tendinitis. Various injection therapies have been used for the treatment of rotator cuff disease, including corticosteroid, prolotherapy, platelet-rich plasma, stem cells, and ultrasound-guided barbotage for calcific tendinitis. However, the existing evidence for these therapies remains controversial or sparse...
April 2018: Orthopedic Clinics of North America
https://www.readbyqxmd.com/read/29403602/comparative-effectiveness-of-intra-articular-prolotherapy-versus-peri-articular-prolotherapy-on-pain-reduction-and-improving-function-in-patients-with-knee-osteoarthritis-a-randomized-clinical-trial
#8
Hamid Reza Farpour, Farzane Fereydooni
Background: Osteoarthritis is a common degenerative disease. Prolotherapy is an alternative therapy used in multiple musculoskeletal disorders. Objective: To compare the effectiveness of intra-articular dextrose injection versus peri-articular prolotherapy in patients with knee osteoarthritis (KOA). Methods: Fifty-two adults with painful primary knee osteoarthritis for at least three months were randomized to intra- and peri-articular injection groups...
November 2017: Electronic Physician
https://www.readbyqxmd.com/read/29379278/the-effects-of-injecting-intra-articular-platelet-rich-plasma-or-prolotherapy-on-pain-score-and-function-in-knee-osteoarthritis
#9
Poupak Rahimzadeh, Farnad Imani, Seyed Hamid Reza Faiz, Saeed Reza Entezary, Mahnaz Narimani Zamanabadi, Mahmoud Reza Alebouyeh
Introduction: Osteoarthritis (OA) is a chronic joint disease that usually occurs in older people and leads to pain and disabilities. OA treatment ranges from drug therapy to surgery. Drug and rehabilitation therapy are preferred over surgery, and, especially, there is a tendency toward compounds causing regenerative changes in the knee joint. In the present study, the effects of platelet-rich plasma (PRP) injection and prolotherapy (PRL) were examined on the level of pain and function of the knee joint in patients with OA...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29319178/glucose-enhances-aggrecan-expression-in-chondrocytes-via-the-pkc%C3%AE-p38-mir141-3p-signaling-pathway
#10
Tsung-Ju Wu, Yi-Chin Fong, Chih-Yang Lin, Yuan-Li Huang, Chih-Hsin Tang
Aggrecan is a high molecular weight proteoglycan that plays a critical role in cartilage structure and the function of joints, providing intervertebral disc and cartilage with the ability to resist compressive loads. Aggrecan degradation in articular cartilage is a significant event in early-stage osteoarthritis (OA). Currently, no effective treatment exists for OA other than pain relief. Dextrose (D-glucose) prolotherapy has shown promising activity in the treatment of different musculoskeletal disorders, including OA...
January 10, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29173661/sacroiliac-joint-interventions
#11
REVIEW
David A Soto Quijano, Eduardo Otero Loperena
Sacroiliac joint (SIJ) pain is an important cause of lower back problems. Multiple SIJ injection techniques have been proposed over the years to help in the diagnosis and treatment of this condition. However, the SIJ innervation is complex and variable, and truly intra-articular injections are sometimes difficult to obtain. Different sacroiliac joint injections have shown to provide pain relief in patients suffering this ailment. Various techniques for intraarticular injections, sacral branch blocks and radiofrequency ablation, both fluoroscopy guided and ultrasound guided are discussed in this paper...
February 2018: Physical Medicine and Rehabilitation Clinics of North America
https://www.readbyqxmd.com/read/29173658/prolotherapy-for-the-thoracolumbar-myofascial-system
#12
REVIEW
Bradley D Fullerton
Prolotherapy has focused on entheses as a key source of chronic low back pain, even without clear diagnosis of enthesopathy. Treatment has traditionally been guided by anatomic knowledge and careful palpation. This article integrates ultrasonographic diagnosis of fascial injury with examination findings taught in traditional prolotherapy technique. Thoracolumbar fascial anatomy and biotensegrity theory are used to explain patient presentation and response to treatment at these pathologic findings. Detailed case reports provide proof of concept for the 60-year history of prolotherapy in the treatment of chronic low back pain...
February 2018: Physical Medicine and Rehabilitation Clinics of North America
https://www.readbyqxmd.com/read/29101774/dextrose-prolotherapy-for-chronic-shoulder-pain-a-case-report
#13
Casey Seenauth, Vance Inouye, Jeffrey O Langland
Context • Shoulder pain is one of the most common pain complaints reported by patients. Consensus is lacking on its ideal treatment, and many different treatments are available and used. Prolotherapy is an injection-based therapy that has shown significant results in treating many common musculoskeletal pain conditions, including osteoarthritis, lateral epicondylosis, and low-back pain. Objective • The study intended to evaluate the use of dextrose prolotherapy in the treatment of shoulder pain. Design • The research team performed a case study...
January 2018: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/29031343/musculoskeletal-injuries-and-regenerative-medicine-in-the-elderly-patient
#14
REVIEW
John C Cianca, Prathap Jayaram
Regenerative medicine has gained increasing popularity in its clinical applications, particularly in the field of musculoskeletal medicine. Regenerative medicine, a broad term, can be thought of as a particular medical strategy that strives to rebuild and restore diseased tissue to normal physiologic tissue baseline. Simply put, regenerative strategies augment the body's innate physiology to heal pathologic processes. This article focuses on specific regenerative strategies and the uses of them for common pathologies in the aging adult, including platelet-rich plasma, mesenchymal stem cells, viscosupplementation, and prolotherapy...
November 2017: Physical Medicine and Rehabilitation Clinics of North America
https://www.readbyqxmd.com/read/29017019/results-of-combined-single-session-arthrocentesis-and-dextrose-prolotherapy-for-symptomatic-temporomandibular-joint-syndrome-a-case-series
#15
Burak Cezairli, Efe Can Sivrikaya, Mehmet Melih Omezli, Ferhat Ayranci, Neslihan Seyhan Cezairli
OBJECTIVE: Arthrocentesis and prolotherapy are nonsurgical treatments for temporomandibular joint (TMJ) diseases. This study aimed to evaluate the treatment of hypermobility, pain, and displacement of the TMJ by consecutively performing arthrocentesis and prolotherapy in the same session. MATERIALS AND METHODS: In this study, 10 adults with disc displacement and painful, hypermobile TMJ were selected. Arthrocentesis and prolotherapy were consecutively performed using a 30% dextrose solution that was simultaneously injected into five areas: posterior disc attachment, superior joint space, superior and inferior capsular attachments, and stylomandibular ligament...
October 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28980027/-insertional-achilles-tendinopathy-differentiated-diagnostics-and-therapy
#16
REVIEW
S F Baumbach, M Braunstein, M G Mack, F Maßen, W Böcker, S Polzer, H Polzer
Achilles tendinopathy at the calcaneal insertion is classified into insertional tendinopathy, retrocalcaneal and superficial bursitis. The aim of this study was to present the current evidence on conservative and surgical treatment of insertional tendinopathy of the Achilles tendon. Conservative first-line therapy includes reduction of activity levels, administration of non-steroidal anti-inflammatory drugs (NSAID), adaptation of footwear, heel wedges and orthoses or immobilization. In addition, further conservative therapy options are also available...
December 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/28920043/short-term-analgesic-effects-of-5-dextrose-epidural-injections-for-chronic-low-back-pain-a-randomized-controlled-trial
#17
Liza Maniquis-Smigel, Kenneth Dean Reeves, Howard Jeffrey Rosen, John Lyftogt, Cassie Graham-Coleman, An-Lin Cheng, David Rabago
BACKGROUND: Hypertonic dextrose injection (prolotherapy) is reported to reduce pain including non-surgical chronic low back pain (CLBP), and subcutaneous injection of 5% dextrose is reported to reduce neurogenic pain, hyperalgesia and allodynia. The mechanism in both cases is unclear, though a direct effect of dextrose on neurogenic pain has been proposed. This study assessed the short-term analgesic effects of epidural 5% dextrose injection compared with saline for non-surgical CLBP...
February 2017: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/28717615/outcomes-of-prolotherapy-for-intra-tendinous-achilles-tears-a-case-series
#18
Otto Chan, Ben Havard, Sarah Morton, Mel Pritchard, Nicola Maffulli, Tom Crisp, Nat Padhiar, Jeremy David Perry, John King, Dylan Morrissey
BACKGROUND: The intra-tendinous tear is a new pathology that is defined as a discontinuity of fibres situated entirely within the tendon. Prolotherapy involves injecting an irritant, such as hyperosmolar dextrose, to stimulate a tissue healing response and ultimately reduce pain. METHODS: 43 consecutive patients diagnosed with an intra-tendinous tear were included (27 males: 16 females, mean (SD) age 41 (11.3). Patients were injected with 0.4ml-1.5ml (mean 0.8ml) of 50% dextrose and 0...
January 2017: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28597118/corr-insights-%C3%A2-prolotherapy-induces-an-inflammatory-response-in-human-tenocytes-in-vitro
#19
COMMENT
Benjamin K Potter
No abstract text is available yet for this article.
August 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28553139/periarticular-dextrose-prolotherapy-instead-of-intra-articular-injection-for-pain-and-functional-improvement-in-knee-osteoarthritis
#20
Zahra Rezasoltani, Mehrdad Taheri, Morteza Kazempour Mofrad, Seyed Amir Mohajerani
BACKGROUND: Osteoarthritis (OA) is a degenerative disease that can lead to painful and dysfunctional joints. Prolotherapy involves using injections to produce functional restoration of the soft tissues of the joint. Intra-articular injections are controversial because of the introduction of needles into the articular capsule. OBJECTIVES: To compare the effect of periarticular versus intra-articular prolotherapy on pain and disability in patients with knee OA. STUDY DESIGN: Randomized double-blind controlled clinical trial...
2017: Journal of Pain Research
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