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https://www.readbyqxmd.com/read/28291395/prospective-evaluation-of-intra-articular-dextrose-prolotherapy-for-treatment-of-osteoarthritis-in-dogs
#1
J Matthew Sherwood, James K Roush, Laura J Armbrust, Walter C Renberg
The objective of this study was to evaluate intra-articular dextrose prolotherapy for osteoarthritis of the elbow or stifle in dogs in a randomized, double-blind, placebo-controlled, prospective pilot study. Seventeen dogs were evaluated with 10 meeting inclusion criteria for this study. Evaluations included orthopedic exam, visual lameness scoring, Canine Brief Pain Inventory (CBPI), goniometry, kinetic gait analysis, and radiography. Initial lameness score, age, body weight, duration of lameness, and CBPI scores did not differ between groups...
March 14, 2017: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/28257672/midsubstance-tendinopathy-percutaneous-techniques-platelet-rich-plasma-extracorporeal-shock-wave-therapy-prolotherapy-radiofrequency-ablation
#2
REVIEW
William Bret Smith, Will Melton, James Davies
The focus of this article is to present the current options available for noninvasive and percutaneous treatment options for noninsertional Achilles tendinopathy. An attempt is made to offer recommendations for both the treatment techniques as well as postprocedure protocols to be considered. Additionally, because there are numerous treatment options in this category, the different techniques are summarized in a chart format with a short list of pros and cons as well as the levels of evidence in the literature to support the different modalities...
April 2017: Clinics in Podiatric Medicine and Surgery
https://www.readbyqxmd.com/read/28218386/glucose-adsorption-to-chitosan-membranes-increases-proliferation-of-human-chondrocyte-via-mammalian-target-of-rapamycin-complex-1-and-sterol-regulatory-element-binding-protein-1-signaling
#3
Shun-Fu Chang, Kuo-Chin Huang, Chin-Chang Cheng, Yu-Ping Su, Ko-Chao Lee, Cheng-Nan Chen, Hsin-I Chang
BACKGROUND: Osteoarthritis (OA) is currently still an irreversible degenerative disease of the articular cartilage. Recent, dextrose (D-glucose) intraarticular injection prolotherapy for OA patients has been reported to benefit the chondrogenic stimulation of damaged cartilage. However, the detailed mechanism of glucose's effect on cartilage repair remains unclear. Chitosan, a naturally derived polysaccharide, has recently been investigated as a surgical or dental dressing to control breeding...
February 20, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28215611/effectiveness-of-prolotherapy-in-the-treatment-of-chronic-rotator-cuff-lesions
#4
Mehmet Murat Seven, Omer Ersen, Serkan Akpancar, Huseyin Ozkan, Selim Turkkan, Yavuz Yıldız, Kenan Koca
BACKGROUND: Rotator cuff lesions are one of the major causes of shoulder pain and dysfunction. Numerous non-surgical treatment modalities have been described for chronic rotator cuff lesions, but the debate continues over the optimal procedure. The aim of this report is to present the results of prolotherapy in the treatment of chronic refractory rotator cuff lesions. HYPOTHESIS: Dextrose prolotherapy will reduce pain and improve shoulder function and patient satisfaction...
February 16, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28002322/the-effect-of-polydeoxyribonucleotide-prolotherapy-on-posterior-tibial-tendon-dysfunction-after-ankle-syndesmotic-surgery-a-case-report
#5
Tae-Ha Lim, Hyung Rae Cho, Keum Nae Kang, Chang Joon Rhyu, Sung Won Chon, Young Su Lim, Jee In Yoo, Jung-Won Kim, Young Uk Kim
RATIONALE: Ankle syndesmotic injuries occasionally require long-term therapy for recovery and can result in tendon injury. Posterior tibial tendon dysfunction (PTTD) is an acquired deformity that can cause flatfoot deformity. The current nonoperative management of PTTD includes nonsteroidal antiinflammatory drugs (NSAIDs), orthopedic devices. Although various treatment options have been attempted, optimal treatments for each stage of the condition are debated. Polydeoxyribonucleotide (PDRN) is effective in healing of chronic wounds associated with tissue damage by attracting tissue growth factors...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27974984/technical-innovation-case-report-ultrasound-guided-prolotherapy-injection-for-insertional-achilles-calcific-tendinosis
#6
Benjamin K Buchanan, Jesse P DeLuca, Kyle P Lammlein
We describe the use of ultrasound guidance for hyperosmolar dextrose (prolotherapy) injection of the distal calcaneal tendon specifically just anterior to identified enthesophytes in patients with insertional Achilles calcific tendinosis refractory to conservative treatment. This specific technique has not to our knowledge been described or used in literature previously.
2016: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/27799816/comparative-effectiveness-of-dextrose-prolotherapy-versus-control-injections-and-exercise-in-the-management-of-osteoarthritis-pain-a-systematic-review-and-meta-analysis
#7
Chen-Yu Hung, Ming-Yen Hsiao, Ke-Vin Chang, Der-Sheng Han, Tyng-Guey Wang
BACKGROUND: Increasing evidence has supported the use of dextrose prolotherapy for patients with osteoarthritis. However, the real benefits may be affected by differences in injection protocols, comparative regimens, and evaluation scales. METHODS: PubMed and Scopus were searched from the earliest record until February 2016. One single-arm study and five randomized controlled trials were included, comprising 326 participants. We estimated the effect sizes of pain reduction before and after serial dextrose injections and compared the values between dextrose prolotherapy, comparative regimens, and exercise 6 months after the initial injection...
2016: Journal of Pain Research
https://www.readbyqxmd.com/read/27788902/dextrose-prolotherapy-a-narrative-review-of-basic-science-clinical-research-and-best-treatment-recommendations
#8
REVIEW
Kenneth Dean Reeves, Regina W S Sit, David P Rabago
Prolotherapy involves the injection of nonbiologic solutions, typically at soft tissue attachments and within joint spaces, to reduce pain and improve function in painful musculoskeletal conditions. A variety of solutions have been used; dextrose prolotherapy is the most rigorously studied and is the focus of this review. Although the mechanism of action is not clearly known, it is likely to be multifactorial. Data on effectiveness for temporomandibular dysfunction are promising but insufficient for recommendations...
November 2016: Physical Medicine and Rehabilitation Clinics of North America
https://www.readbyqxmd.com/read/27673137/poster-383-effects-of-dextrose-prolotherapy-in-the-treatment-of-patients-with-knee-osteoarthritis-a-randomized-controlled-trial
#9
Alketa Toska Sert, Emel Ozcan, Sina Esmaeilzadeh
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27660427/clinical-effectiveness-in-severe-knee-osteoarthritis-after-intra-articular-platelet-rich-plasma-therapy-in-association-with-hyaluronic-acid-injection-three-case-reports
#10
Szu-Hsuan Chen, Ta-Shen Kuan, Mu-Jung Kao, Wei-Ting Wu, Li-Wei Chou
Osteoarthritis (OA) is a degenerative disorder resulting from loss of joint cartilage and underlying bone and causes pain and loss of function. The treatment of knee OA is still a challenge because of the poor self-regeneration capacity of cartilage. The nonsurgical interventions include control of the aggravating factor (such as weight control and the use of walking aids), symptomatic treatment (such as acetaminophen or nonsteroidal anti-inflammatory drugs), prolotherapy, and viscosupplementation. However, the combination of platelet-rich plasma (PRP) and hyaluronic acid (HA) has not been widely used because of lack of clinical evidence and several limitations in patients with severe knee OA...
2016: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/27603001/qualitative-assessment-of-patients-receiving-prolotherapy-for-knee-osteoarthritis-in-a-multimethod-study
#11
David Rabago, Laura van Leuven, Lane Benes, Luke Fortney, Andrew Slattengren, Jessica Grettie, Marlon Mundt
OBJECTIVE: Randomized and open-label studies assessing prolotherapy for knee osteoarthritis have found quantitative improvement on the validated Western Ontario McMaster University Osteoarthritis Index (WOMAC) compared with baseline status and control therapies. This study assessed the qualitative response of participants receiving prolotherapy, an injection-based complementary treatment for symptomatic knee osteoarthritis (OA). DESIGN: Qualitative study using semi-structured in-depth interviews at 52 weeks after enrollment; transcribed responses were discussed by coauthors to identify themes; disagreement was resolved by consensus...
December 2016: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/27468674/orthobiologic-interventions-using-ultrasound-guidance
#12
REVIEW
Gerard Malanga, Dena Abdelshahed, Prathap Jayaram
The application of regenerative therapies for the treatment of musculoskeletal conditions has emerged over the last decade with recent acceleration. These include prolotherapy, platelet-rich plasma, and mesenchymal stem cell therapy. These strategies augment the body's innate physiology to heal pathologic processes. This article presents an overview of platelet-rich plasma and mesenchymal stem cell therapy for the treatment of musculoskeletal injuries. A brief literature review is included, as are techniques for the use of ultrasound guidance to assist with these procedures...
August 2016: Physical Medicine and Rehabilitation Clinics of North America
https://www.readbyqxmd.com/read/27429562/a-systematic-review-of-dextrose-prolotherapy-for-chronic-musculoskeletal-pain
#13
REVIEW
Ross A Hauser, Johanna B Lackner, Danielle Steilen-Matias, David K Harris
OBJECTIVE: The aim of this study was to systematically review dextrose (d-glucose) prolotherapy efficacy in the treatment of chronic musculoskeletal pain. DATA SOURCES: Electronic databases PubMed, Healthline, OmniMedicalSearch, Medscape, and EMBASE were searched from 1990 to January 2016. STUDY SELECTION: Prospectively designed studies that used dextrose as the sole active prolotherapy constituent were selected. DATA EXTRACTION: Two independent reviewers rated studies for quality of evidence using the Physiotherapy Evidence Database assessment scale for randomized controlled trials (RCTs) and the Downs and Black evaluation tool for non-RCTs, for level of evidence using a modified Sackett scale, and for clinically relevant pain score difference using minimal clinically important change criteria...
2016: Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27146849/hypertonic-dextrose-injections-prolotherapy-in-the-treatment-of-symptomatic-knee-osteoarthritis-a-systematic-review-and-meta-analysis
#14
Regina Ws Sit, Vincent Ch Chung, Kenneth D Reeves, David Rabago, Keith Kw Chan, Dicken Cc Chan, Xinyin Wu, Robin St Ho, Samuel Ys Wong
Hypertonic dextrose injections (prolotherapy) is an emerging treatment for symptomatic knee osteoarthritis (OA) but its efficacy is uncertain. We conducted a systematic review with meta-analysis to synthesize clinical evidence on the effect of prolotherapy for knee OA. Fifteen electronic databases were searched from their inception to September 2015. The primary outcome of interest was score change on the Western Ontario and McMaster Universities Arthritis Index (WOMAC). Three randomized controlled trials (RCTs) of moderate risk of bias and one quasi-randomized trial were included, with data from a total of 258 patients...
May 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27058744/chondrogenic-effect-of-intra-articular-hypertonic-dextrose-prolotherapy-in-severe-knee-osteoarthritis
#15
Gastón Andrés Topol, Leandro Ariel Podesta, Kenneth Dean Reeves, Marcia Mallma Giraldo, Lanny L Johnson, Raul Grasso, Alexis Jamín, Tom Clark, David Rabago
BACKGROUND: Dextrose injection is reported to improve knee osteoarthritis (KOA)-related clinical outcomes, but its effect on articular cartilage is unknown. A chondrogenic effect of dextrose injection has been proposed. OBJECTIVE: To assess biological and clinical effects of intra-articular hypertonic dextrose injections (prolotherapy) in painful KOA. DESIGN: Case series with blinded arthroscopic evaluation before and after treatment. SETTING: Physical medicine and day surgery practice...
November 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27015027/-conservative-treatment-of-tendinopathies-of-upper-limbs-in-occupational-health-a-literature-review
#16
REVIEW
Francesco Sartorio, Fabiola Garzonio, Stefano Vercelli, Elisabetta Bravini, Carolina Ruella, Roberto Maglio, Carlo Cisari, Giorgio Ferriero
BACKGROUND: In the last few years, the incidence of upper limbs tendon injuries has seen a dramatic increase among workers. Conservative treatment is the first choice to relieve symptoms, allowing a safe return to work. However, the scientific evidence of its  efficacy is widely debated. OBJECTIVE AND METHODS: Research and literature review on the efficacy of conservative treatment of upper limbs tendon injuries in occupational settings. RESULTS: A total of 271 references were found on Medline and Embase up to May 2015...
March 24, 2016: La Medicina del Lavoro
https://www.readbyqxmd.com/read/26846795/is-dextrose-prolotherapy-superior-to-placebo-for-the-treatment-of-temporomandibular-joint-hypermobility-a-randomized-clinical-trial
#17
S Cömert Kiliç, M Güngörmüş
A randomized clinical trial involving adult patients with bilateral temporomandibular joint (TMJ) hypermobility referred for treatment was implemented. The sample comprised 30 consecutive patients, who were divided randomly into two groups. The TMJ hypermobility was treated with either saline (placebo group) or dextrose injections (study group). The solution was injected into five different TMJ areas in three sessions at monthly intervals. The predictor variable was the treatment technique. The outcome variables were visual analogue scale (VAS) evaluations and maximum inter-incisal opening (MIO)...
July 2016: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/26844994/prolotherapy-can-it-help-your-patient
#18
REVIEW
Carlton J Covey, Marvin H Sineath, Joseph F Penta, Jeffrey C Leggit
No abstract text is available yet for this article.
December 2015: Journal of Family Practice
https://www.readbyqxmd.com/read/26587401/the-effects-of-prolotherapy-with-hypertonic-dextrose-versus-prolozone-intraarticular-ozone-in-patients-with-knee-osteoarthritis
#19
Masoud Hashemi, Parviz Jalili, Shirin Mennati, Alireza Koosha, Ramin Rohanifar, Firouz Madadi, Seyed Sajad Razavi, Farinaz Taheri
BACKGROUND: Knee osteoarthritis (KOA) is a common disabling disease. Limited studies have demonstrated that prolotherapy with dextrose or with prolozone can be helpful in the treatment of patients with KOA. OBJECTIVES: In the current study, we compared the results between these two treatment methods. PATIENTS AND METHODS: In the current randomized clinical trial, 80 patients with mild to moderate KOA were randomly assigned equally into two groups (ozone group and dextrose group)...
October 2015: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/26543503/erratum-to-effectiveness-and-safety-of-prolotherapy-injections-for-management-of-lower-limb-tendinopathy-and-fasciopathy-a-systematic-review
#20
Lane M Sanderson, Alan Bryant
[This corrects the article DOI: 10.1186/s13047-015-0114-5.].
2015: Journal of Foot and Ankle Research
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