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https://www.readbyqxmd.com/read/27799816/comparative-effectiveness-of-dextrose-prolotherapy-versus-control-injections-and-exercise-in-the-management-of-osteoarthritis-pain-a-systematic-review-and-meta-analysis
#1
Chen-Yu Hung, Ming-Yen Hsiao, Ke-Vin Chang, Der-Sheng Han, Tyng-Guey Wang
BACKGROUND: Increasing evidence has supported the use of dextrose prolotherapy for patients with osteoarthritis. However, the real benefits may be affected by differences in injection protocols, comparative regimens, and evaluation scales. METHODS: PubMed and Scopus were searched from the earliest record until February 2016. One single-arm study and five randomized controlled trials were included, comprising 326 participants. We estimated the effect sizes of pain reduction before and after serial dextrose injections and compared the values between dextrose prolotherapy, comparative regimens, and exercise 6 months after the initial injection...
2016: Journal of Pain Research
https://www.readbyqxmd.com/read/27788902/dextrose-prolotherapy-a-narrative-review-of-basic-science-clinical-research-and-best-treatment-recommendations
#2
REVIEW
Kenneth Dean Reeves, Regina W S Sit, David P Rabago
Prolotherapy involves the injection of nonbiologic solutions, typically at soft tissue attachments and within joint spaces, to reduce pain and improve function in painful musculoskeletal conditions. A variety of solutions have been used; dextrose prolotherapy is the most rigorously studied and is the focus of this review. Although the mechanism of action is not clearly known, it is likely to be multifactorial. Data on effectiveness for temporomandibular dysfunction are promising but insufficient for recommendations...
November 2016: Physical Medicine and Rehabilitation Clinics of North America
https://www.readbyqxmd.com/read/27673137/poster-383-effects-of-dextrose-prolotherapy-in-the-treatment-of-patients-with-knee-osteoarthritis-a-randomized-controlled-trial
#3
Alketa Toska Sert, Emel Ozcan, Sina Esmaeilzadeh
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27660427/clinical-effectiveness-in-severe-knee-osteoarthritis-after-intra-articular-platelet-rich-plasma-therapy-in-association-with-hyaluronic-acid-injection-three-case-reports
#4
Szu-Hsuan Chen, Ta-Shen Kuan, Mu-Jung Kao, Wei-Ting Wu, Li-Wei Chou
Osteoarthritis (OA) is a degenerative disorder resulting from loss of joint cartilage and underlying bone and causes pain and loss of function. The treatment of knee OA is still a challenge because of the poor self-regeneration capacity of cartilage. The nonsurgical interventions include control of the aggravating factor (such as weight control and the use of walking aids), symptomatic treatment (such as acetaminophen or nonsteroidal anti-inflammatory drugs), prolotherapy, and viscosupplementation. However, the combination of platelet-rich plasma (PRP) and hyaluronic acid (HA) has not been widely used because of lack of clinical evidence and several limitations in patients with severe knee OA...
2016: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/27603001/qualitative-assessment-of-patients-receiving-prolotherapy-for-knee-osteoarthritis-in-a-multimethod-study
#5
David Rabago, Laura van Leuven, Lane Benes, Luke Fortney, Andrew Slattengren, Jessica Grettie, Marlon Mundt
OBJECTIVE: Randomized and open-label studies assessing prolotherapy for knee osteoarthritis have found quantitative improvement on the validated Western Ontario McMaster University Osteoarthritis Index (WOMAC) compared with baseline status and control therapies. This study assessed the qualitative response of participants receiving prolotherapy, an injection-based complementary treatment for symptomatic knee osteoarthritis (OA). DESIGN: Qualitative study using semi-structured in-depth interviews at 52 weeks after enrollment; transcribed responses were discussed by coauthors to identify themes; disagreement was resolved by consensus...
September 7, 2016: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/27468674/orthobiologic-interventions-using-ultrasound-guidance
#6
REVIEW
Gerard Malanga, Dena Abdelshahed, Prathap Jayaram
The application of regenerative therapies for the treatment of musculoskeletal conditions has emerged over the last decade with recent acceleration. These include prolotherapy, platelet-rich plasma, and mesenchymal stem cell therapy. These strategies augment the body's innate physiology to heal pathologic processes. This article presents an overview of platelet-rich plasma and mesenchymal stem cell therapy for the treatment of musculoskeletal injuries. A brief literature review is included, as are techniques for the use of ultrasound guidance to assist with these procedures...
August 2016: Physical Medicine and Rehabilitation Clinics of North America
https://www.readbyqxmd.com/read/27429562/a-systematic-review-of-dextrose-prolotherapy-for-chronic-musculoskeletal-pain
#7
REVIEW
Ross A Hauser, Johanna B Lackner, Danielle Steilen-Matias, David K Harris
OBJECTIVE: The aim of this study was to systematically review dextrose (d-glucose) prolotherapy efficacy in the treatment of chronic musculoskeletal pain. DATA SOURCES: Electronic databases PubMed, Healthline, OmniMedicalSearch, Medscape, and EMBASE were searched from 1990 to January 2016. STUDY SELECTION: Prospectively designed studies that used dextrose as the sole active prolotherapy constituent were selected. DATA EXTRACTION: Two independent reviewers rated studies for quality of evidence using the Physiotherapy Evidence Database assessment scale for randomized controlled trials (RCTs) and the Downs and Black evaluation tool for non-RCTs, for level of evidence using a modified Sackett scale, and for clinically relevant pain score difference using minimal clinically important change criteria...
2016: Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27146849/hypertonic-dextrose-injections-prolotherapy-in-the-treatment-of-symptomatic-knee-osteoarthritis-a-systematic-review-and-meta-analysis
#8
Regina Ws Sit, Vincent Ch Chung, Kenneth D Reeves, David Rabago, Keith Kw Chan, Dicken Cc Chan, Xinyin Wu, Robin St Ho, Samuel Ys Wong
Hypertonic dextrose injections (prolotherapy) is an emerging treatment for symptomatic knee osteoarthritis (OA) but its efficacy is uncertain. We conducted a systematic review with meta-analysis to synthesize clinical evidence on the effect of prolotherapy for knee OA. Fifteen electronic databases were searched from their inception to September 2015. The primary outcome of interest was score change on the Western Ontario and McMaster Universities Arthritis Index (WOMAC). Three randomized controlled trials (RCTs) of moderate risk of bias and one quasi-randomized trial were included, with data from a total of 258 patients...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27058744/chondrogenic-effect-of-intra-articular-hypertonic-dextrose-prolotherapy-in-severe-knee-osteoarthritis
#9
Gastón Andrés Topol, Leandro Ariel Podesta, Kenneth Dean Reeves, Marcia Mallma Giraldo, Lanny L Johnson, Raul Grasso, Alexis Jamín, Tom Clark, David Rabago
BACKGROUND: Dextrose injection is reported to improve knee osteoarthritis (KOA)-related clinical outcomes, but its effect on articular cartilage is unknown. A chondrogenic effect of dextrose injection has been proposed. OBJECTIVE: To assess biological and clinical effects of intra-articular hypertonic dextrose injections (prolotherapy) in painful KOA. DESIGN: Case series with blinded arthroscopic evaluation before and after treatment. SETTING: Physical medicine and day surgery practice...
April 4, 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27015027/-conservative-treatment-of-tendinopathies-of-upper-limbs-in-occupational-health-a-literature-review
#10
REVIEW
Francesco Sartorio, Fabiola Garzonio, Stefano Vercelli, Elisabetta Bravini, Carolina Ruella, Roberto Maglio, Carlo Cisari, Giorgio Ferriero
BACKGROUND: In the last few years, the incidence of upper limbs tendon injuries has seen a dramatic increase among workers. Conservative treatment is the first choice to relieve symptoms, allowing a safe return to work. However, the scientific evidence of its  efficacy is widely debated. OBJECTIVE AND METHODS: Research and literature review on the efficacy of conservative treatment of upper limbs tendon injuries in occupational settings. RESULTS: A total of 271 references were found on Medline and Embase up to May 2015...
March 2016: La Medicina del Lavoro
https://www.readbyqxmd.com/read/26846795/is-dextrose-prolotherapy-superior-to-placebo-for-the-treatment-of-temporomandibular-joint-hypermobility-a-randomized-clinical-trial
#11
S Cömert Kiliç, M Güngörmüş
A randomized clinical trial involving adult patients with bilateral temporomandibular joint (TMJ) hypermobility referred for treatment was implemented. The sample comprised 30 consecutive patients, who were divided randomly into two groups. The TMJ hypermobility was treated with either saline (placebo group) or dextrose injections (study group). The solution was injected into five different TMJ areas in three sessions at monthly intervals. The predictor variable was the treatment technique. The outcome variables were visual analogue scale (VAS) evaluations and maximum inter-incisal opening (MIO)...
July 2016: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/26844994/prolotherapy-can-it-help-your-patient
#12
REVIEW
Carlton J Covey, Marvin H Sineath, Joseph F Penta, Jeffrey C Leggit
No abstract text is available yet for this article.
December 2015: Journal of Family Practice
https://www.readbyqxmd.com/read/26587401/the-effects-of-prolotherapy-with-hypertonic-dextrose-versus-prolozone-intraarticular-ozone-in-patients-with-knee-osteoarthritis
#13
Masoud Hashemi, Parviz Jalili, Shirin Mennati, Alireza Koosha, Ramin Rohanifar, Firouz Madadi, Seyed Sajad Razavi, Farinaz Taheri
BACKGROUND: Knee osteoarthritis (KOA) is a common disabling disease. Limited studies have demonstrated that prolotherapy with dextrose or with prolozone can be helpful in the treatment of patients with KOA. OBJECTIVES: In the current study, we compared the results between these two treatment methods. PATIENTS AND METHODS: In the current randomized clinical trial, 80 patients with mild to moderate KOA were randomly assigned equally into two groups (ozone group and dextrose group)...
October 2015: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/26543503/erratum-to-effectiveness-and-safety-of-prolotherapy-injections-for-management-of-lower-limb-tendinopathy-and-fasciopathy-a-systematic-review
#14
Lane M Sanderson, Alan Bryant
[This corrects the article DOI: 10.1186/s13047-015-0114-5.].
2015: Journal of Foot and Ankle Research
https://www.readbyqxmd.com/read/26424616/epidural-abscess-from-prolotherapy-a-cautionary-tale
#15
Thomas Clifton, Michael Selby
No abstract text is available yet for this article.
September 30, 2015: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/26392595/injection-therapies-for-lateral-epicondylalgia-a-systematic-review-and-bayesian-network-meta-analysis
#16
Wei Dong, Hans Goost, Xiang-Bo Lin, Christof Burger, Christian Paul, Zeng-Li Wang, Fan-Lin Kong, Kristian Welle, Zhi-Chao Jiang, Koroush Kabir
BACKGROUND: There are many injection therapies for lateral epicondylalgia but there has been no previous comprehensive comparison, based on the Bayesian method. METHODS: The MEDLINE, EMBASE and the Cochrane Central Register of Controlled Trials (CENTRAL) databases were searched for appropriate literature. The outcome measurement was the pain score. Direct comparisons were performed using the pairwise meta-analysis, and network meta-analysis, based on a Bayesian model, was used to calculate the results of all of the potentially possible comparisons and rank probabilities...
August 2016: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/26309378/chronic-sacroiliac-joint-and-pelvic-girdle-dysfunction-in-a-35-year-old-nulliparous-woman-successfully-managed-with-multimodal-and-multidisciplinary-approach
#17
Holly Jonely, Jean-Michel Brismée, Mehul J Desai, Rachel Reoli
BACKGROUND AND PURPOSE: Sacroiliac joint pain and dysfunction affect 15-25% of patients reporting low back pain, including reports of spontaneous, idiopathic, traumatic, and non-traumatic onsets. The poor reliability and validity associated with diagnostic clinical and imaging techniques leads to challenges in diagnosing and managing sacroiliac joint dysfunction. CASE DESCRIPTION: A 35-year-old nulliparous female with a 14-year history of right sacroiliac joint dysfunction was managed using a multimodal and multidisciplinary approach when symptoms failed to resolve after 2 months of physical therapy...
February 2015: Journal of Manual & Manipulative Therapy
https://www.readbyqxmd.com/read/26301385/dextrose-prolotherapy-versus-control-injections-in-painful-rotator-cuff-tendinopathy
#18
RANDOMIZED CONTROLLED TRIAL
Helene Bertrand, Kenneth Dean Reeves, Cameron J Bennett, Simon Bicknell, An-Lin Cheng
OBJECTIVE: To compare the effect of dextrose prolotherapy on pain levels and degenerative changes in painful rotator cuff tendinopathy against 2 potentially active control injection procedures. DESIGN: Randomized controlled trial, blinded to participants and evaluators. SETTING: Outpatient pain medicine practice. PARTICIPANTS: Persons (N=73) with chronic shoulder pain, examination findings of rotator cuff tendinopathy, and ultrasound-confirmed supraspinatus tendinosis/tear...
January 2016: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/26254952/prolotherapy-for-refractory-rotator-cuff-disease-retrospective-case-control-study-of-1-year-follow-up
#19
Doo-Hyung Lee, Kyu-Sung Kwack, Ueon Woo Rah, Seung-Hyun Yoon
OBJECTIVE: To determine the efficacy of prolotherapy for refractory rotator cuff disease. DESIGN: Retrospective case-control study. SETTING: University-affiliated tertiary care hospital. PARTICIPANTS: Patients with nontraumatic refractory rotator cuff disease (N=151) who were unresponsive to 3 months of aggressive conservative treatment. Of the patients, 63 received prolotherapies with 16.5% dextrose 10-ml solution (treatment group), and 63 continued conservative treatment (control group)...
November 2015: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/26114106/new-developments-in-the-use-of-biologics-and-other-modalities-in-the-management-of-lateral-epicondylitis
#20
REVIEW
Cynthia A Kahlenberg, Michael Knesek, Michael A Terry
Lateral epicondylitis is a common source of elbow pain. Though it is often a self-limited condition, refractory lateral epicondylitis can lead to problems with activities of daily living and sometimes requires sick leave from work. Therefore prompt treatment is essential. Histopathologic studies have suggested that lateral epicondylitis is a tendinopathy, associated with apoptosis and autophagy, rather than a tendonitis associated with inflammation. Although corticosteroids have been used for short-term treatment, recent studies have suggested that they are not helpful and may even be harmful and delay healing in the treatment of lateral epicondylitis...
2015: BioMed Research International
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