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CMV hepatitis

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https://www.readbyqxmd.com/read/27828874/soluble-cd163-in-cmv-infected-and-uninfected-subjects-on-virologically-suppressive-antiretroviral-therapy-in-the-icona-cohort
#1
Serena Vita, Miriam Lichtner, Giulia Marchetti, Claudia Mascia, Esther Merlini, Paola Cicconi, Vincenzo Vullo, Pierluigi Viale, Andrea Costantini, Antonella DʼArminio Monforte
AIMS: To contribute to the understanding of the role played by CMV in sustaining monocyte/macrophage-mediated immune activation in ART treated HIV infected subjects. DESIGN: and Methods: We selected 23 CMV-uninfected and 46 CMV-infected HIV+ subjects, matched for age, CD4 nadir, HIV infection duration, viral hepatitis serostatus. All subjects were on successful ART since at least 1 year. A group of 16 healthy donors with similar age and sex was also included. Plasma levels of TNF-α, IL-6, sCD163, sCD14 and CMV IgG levels were measured in duplicate with human ELISA kits...
November 4, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27822257/co-infection-of-the-hepatitis-c-virus-with-other-blood-borne-and-hepatotropic-viruses-among-hemophilia-patients-in-poland
#2
Marta Kucharska, Malgorzata Inglot, Aleksandra Szymczak, Weronika Rymer, Malgorzata Zalewska, Krzysztof Malyszczak, Urszula Zaleska-Dorobisz, Malgorzata Kuliszkiewicz-Janus
BACKGROUND: The prevalence of HCV infection in people with hemophilia is substantially higher than that in the general population (63% - 98%). Multiple transfusions and substitutive therapy have also been linked to a high risk of HBV and HIV transmission. However, the prevalence of other blood-borne viral infections in this population is less well known. OBJECTIVES: This study aimed to assess the prevalence of co-infection with HBV and other blood-borne viruses in Polish HCV-infected hemophiliacs...
September 2016: Hepatitis Monthly
https://www.readbyqxmd.com/read/27803174/the-third-signal-cytokine-il-12-rather-than-immune-checkpoint-inhibitors-contribute-to-the-functional-restoration-of-hepatitis-d-virus-specific-t-cells
#3
Thomas Schirdewahn, Jan Grabowski, Solomon Owusu Sekyere, Birgit Bremer, Anika Wranke, Sebastian Lunemann, Verena Schlaphoff, Janina Kirschner, Svenja Hardtke, Michael Peter Manns, Markus Cornberg, Heiner Wedemeyer, Pothakamuri Venkata Suneetha
BACKGROUND:  Hepatitis D virus (HDV) infection affects 15-20 million individuals world-wide and causes severely progressive hepatitis. It is unknown to what extent cellular immune responses contribute to liver disease and control of viral replication in HDV infection. METHODS:  Immune cell frequencies and phenotypes were determined in 49 HDV-infected patients, 25 HBV-monoinfected individuals and 18 healthy controls. T-cell proliferative and cytokine-producing capacities were analysed by stimulation with overlapping peptides spanning the large HDV antigen...
October 31, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27800130/the-association-between-viral-infections-and-co-stimulatory-gene-polymorphisms-in-kidney-transplant-outcomes
#4
Ahmad Niknam, Mohammad Hossein Karimi, Ramin Yaghobi, Bita Geramizadeh, Jamshid Roozbeh, Mehdi Salehipour, Mahdiyar Iravani
BACKGROUND: The surveillance of kidney transplant patients depends on function of different immunologic markers like co-stimulatory molecules. These molecules may also be associated with post kidney transplant viral related outcomes. OBJECTIVES: The aim of this study was to investigate the possible associations between co-stimulatory molecule gene polymorphisms and viral infections in kidney transplant patients. PATIENTS AND METHODS: In total, 172 kidney transplant patients were included in this study...
August 2016: Jundishapur Journal of Microbiology
https://www.readbyqxmd.com/read/27775825/impact-of-type-of-calcineurin-inhibitor-on-post-transplant-tuberculosis-single-center-study-from-india
#5
Sanjay K Agarwal, Dipankar Bhowmik, Sandeep Mahajan, Soumita Bagchi
INTRODUCTION: Tuberculosis (TB) is an important cause of morbidity and mortality in renal transplant recipient (RTR). Immunosuppressive drugs are one of the most important risk factor for post-transplant tuberculosis (PTTB). A paucity of data exists about the impact of the type of calcineurin inhibitor on PTTB. METHODS: In this retrospective study, all adult patients on calcineurin inhibitor-based immunosuppression were included. Patients receiving TB chemoprophylaxis were excluded...
October 24, 2016: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/27774722/heart-transplant-outcomes-in-recipients-of-centers-for-disease-control-cdc-high-risk-donors
#6
Athanasios Tsiouris, Lynn Wilson, Rajesh B Sekar, Abeel A Mangi, James J Yun
BACKGROUND: A lack of donor hearts remains a major limitation of heart transplantation. Hearts from Centers for Disease Control (CDC) high-risk donors can be utilized with specific recipient consent. However, outcomes of heart transplantation with CDC high-risk donors are not well known. We sought to define outcomes, including posttransplant hepatitis and human immunodeficiency virus (HIV) status, in recipients of CDC high-risk donor hearts at our institution. METHODS: All heart transplant recipients from August 2010 to December 2014 (n = 74) were reviewed...
December 2016: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/27765700/design-and-evaluation-of-an-edwardsiella-tarda-dna-vaccine-co-encoding-antigenic-and-adjuvant-peptide
#7
Xiaohong Liu, Jinmei Xu, Hua Zhang, Qin Liu, Jingfan Xiao, Yuanxing Zhang
Edwardsiella tarda is associated with edwardsiellosis in cultured fish, resulting in heavy losses in aquaculture. So far, different types of vaccine have been attempted against E. tarda. In this study, an optimized eukaryotic expression plasmid was developed and an optimized DNA vaccine co-encoding antigenic and adjuvant peptide using a bicistronic expression system was designed. As a result, a modified plasmid harbored cytomegalovirus (CMV) promoter attached with R region of long terminal repeat from human T-cell leukemia virus type 1 (CMV/R) and woodchuck hepatitis virus post-transcriptional response element (WPRE) component showed an increased antigenic gene expression compared with unmodified plasmid...
December 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27751206/-research-advances-in-breast-milk-acquired-cytomegalovirus-infection-in-premature-infants
#8
Li-Hong Ran, Lei Bao
Breast milk is considered ideal food for premature infants, but it can also be the main source of cytomegalovirus (CMV) infection in premature infants. CMV infection may cause serious clinical symptoms, such as sepsis-like syndrome, thrombocytopenia, neutropenia, jaundice, hepatitis, and pneumonitis. This article reviews the research advances in symptoms, treatment strategies, prognosis and the prevention of breast milk-acquired CMV infection in premature infants.
October 2016: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/27726464/three-gene-signature-for-predicting-the-development-of-hepatocellular-carcinoma-in-chronically-infected-hepatitis-c-virus-patients
#9
Marwa K Ibrahim, Hosny Salama, Mohamad Abd El Rahman, Reham M Dawood, Noha G Bader El Din, Heba F Salem, Mohamed E A Abdelrahim, Dalia Omran, Moataza H Omran, Khaled Helmi El-Wakeel, Tawfeek H Abdelhafez, Ahmed Khedr, Mostafa K El Awady
Hepatitis C virus (HCV) is the leading cause of liver fibrosis and hepatocellular carcinoma (HCC). At present, there is no predictive biomarker for the patients at high risk of developing HCC. In this study, we examined the association between single-nucleotide polymorphisms (SNPs) in 3 innate immunity genes [2'-5'oligoadenylate synthetase 1 (OAS1) rs10774671, interleukin 28B (IL28B) rs12979860, and low molecular mass polypeptide 7 (LMP-7) at codon 49] besides cytomegalovirus (CMV) coinfection and susceptibility to HCC in genotype 4 (GT4) chronically infected Egyptian patients...
December 2016: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/27697585/human-herpesvirus-6-infection-following-haploidentical-transplantation-immune-recovery-and-outcome
#10
Raffaella Greco, Lara Crucitti, Maddalena Noviello, Sara Racca, Daniele Mannina, Alessandra Forcina, Francesca Lorentino, Veronica Valtolina, Serena Rolla, Roee Dvir, Mara Morelli, Fabio Giglio, Maria Chiara Barbanti, Maria Teresa Lupo Stanghellini, Chiara Oltolini, Luca Vago, Paolo Scarpellini, Andrea Assanelli, Matteo G Carrabba, Sarah Marktel, Massimo Bernardi, Consuelo Corti, Massimo Clementi, Jacopo Peccatori, Chiara Bonini, Fabio Ciceri
Human herpesvirus 6 (HHV-6) is increasingly recognized as a potentially life-threatening pathogen in allogeneic hematopoietic stem cell transplantation (alloSCT). We retrospectively evaluated 54 adult patients who developed positivity to HHV-6 after alloSCT. The median time from alloSCT to HHV-6 reactivation was 34 days. HHV-6 was present in plasma samples from 31 patients, in bone marrow (BM) of 9 patients, in bronchoalveolar lavage fluid and liver or gut biopsy specimens from 33 patients, and in cerebrospinal fluid of 7 patients...
September 30, 2016: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/27617744/enterovirus-a71-dna-launched-infectious-clone-as-a-robust-reverse-genetic-tool
#11
Chee Wah Tan, Han Kang Tee, Michelle Hui Pheng Lee, I-Ching Sam, Yoke Fun Chan
Enterovirus A71 (EV-A71) causes major outbreaks of hand, foot and mouth disease, and is occasionally associated with neurological complications and death in children. Reverse genetics is widely used in the field of virology for functional study of viral genes. For EV-A71, such tools are limited to clones that are transcriptionally controlled by T7/SP6 bacteriophage promoter. This is often time-consuming and expensive. Here, we describe the development of infectious plasmid DNA-based EV-A71 clones, for which EV-A71 genome expression is under transcriptional control by the CMV-intermediate early promoter and SV40 transcriptional-termination signal...
2016: PloS One
https://www.readbyqxmd.com/read/27600985/role-of-mtor-inhibitors-for-the-control-of-viral-infection-in-solid-organ-transplant-recipients
#12
Julio Pascual, Ana Royuela, Ana M Fernández, Ignacio Herrero, Juan F Delgado, Amparo Solé, Lluis Guirado, Teresa Serrano, Julián de la Torre-Cisneros, Asunción Moreno, Elisa Cordero, Roberto Gallego, Carlos Lumbreras, José M Aguado
Appropriate post-transplant immunosuppressive regimens that avoid acute rejection, while reducing risk of viral reactivation, have been sought, but remain a chimera. Recent evidence suggesting potential regulatory and antiviral effects of mammalian target of rapamycin inhibitors (mTORi) is of great interest. Although the concept of an immunosuppressive drug with antiviral properties is not new, little effort has been made to put the evidence together to assess the management of immunosuppressive therapy in the presence of a viral infection...
September 7, 2016: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/27583207/cytomegalic-hepatitis-in-a-patient-receiving-omalizumab
#13
R Gonçalves, C Valente, E Ferreira, J E Serra, J Saraiva da Cunha
Cytomegalovirus is a double stranded DNA virus that can be present in nearly all organs and body fluids. The primary infection is usually asymptomatic in the immunocompetent host and it is common among adolescents and young adults. The symptomatic form appears, in the majority of cases, as a mononucleosis syndrome with full recovery without specific treatment. We report a case of a 25 years old woman who presented with hepatitis due to CMV infection and history of omalizumab administration one month earlier...
2016: IDCases
https://www.readbyqxmd.com/read/27558941/functional-characterization-of-hepatitis-b-virus-core-promoter-mutants-revealed-transcriptional-interference-among-co-terminal-viral-mrnas
#14
Chaoyang Chen, Haodi Jia, Fei Zhang, Yanli Qin, Li Zong, Quan Yuan, Yongxiang Wang, Ningshao Xia, Jisu Li, Yumei Wen, Shuping Tong
Hepatitis B virus (HBV) has a 3.2 kb circular DNA genome. It employs four promoters in conjunction with a single polyadenylation signal to generate 3.5, 2.4, 2.1 and 0.7 kb co-terminal RNAs. The 3.5 kb RNA is subdivided into the precore RNA for e-antigen expression and pregenomic RNA for genome replication. When introduced to a genotype A clone, several core promoter mutations markedly enhanced HBV genome replication, but suppressed e-antigen expression through up-regulation of pregenomic RNA at the expense of precore RNA...
October 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27525404/-transverse-myelitis-associated-with-toxocariasis-and-the-importance-of-locally-produced-antibodies-for-diagnosis
#15
Serap Ural, Behiye Özer, Fazıl Gelal, Derya Dirim Erdoğan, Nurbanu Sezak, Recep Balık, Tuna Demirdal, Metin Korkmaz
Toxocariasis caused by Toxocara canis or less frequently by T.catis is a common parasitic infection worldwide. Clinical spectrum in humans can vary from asymptomatic infection to serious organ disfunction depending on the load of parasite, migration target of the larva and the inflammatory response of the host. Transverse myelitis (TM) due to toxocariasis is an uncommon illness identified mainly as case reports in literature. In this report, a case of TM who was diagnosed as neurotoxocariasis by serological findings has been presented...
July 2016: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/27495753/fulminant-hepatic-failure-as-a-risk-factor-for-cytomegalovirus-infection-in-children-receiving-preemptive-therapy-after-living-donor-liver-transplantation
#16
Munehiro Furuichi, Takeo Fujiwara, Akinari Fukuda, Mureo Kasahara, Isao Miyairi
BACKGROUND: Cytomegalovirus (CMV) is 1 of the most common causes of infection after solid organ transplantation with symptomatic disease occurring at an incidence of 20-40% without preventative measures. While CMV donor+/recipient- serostatus is well known to be a risk factor, there is little data about other risk factors for CMV infection in the setting of pediatric liver transplantation (LT). We hypothesized that fulminant hepatic failure (FHF) may be a risk factor for CMV infection given anecdotal reports of complications associated with FHF...
August 5, 2016: Transplantation
https://www.readbyqxmd.com/read/27477575/subacute-autonomic-and-sensory-neuropathy-closely-related-to-cytomegalovirus-infection-preceded-by-frequent-syncopal-attacks
#17
Koichi Nakao, Michito Namekawa, Soichi Kondo, Sayaka Ono, Imaharu Nakano
A 73-year-old woman who had hypertension developed a slight fever and general malaise with laboratory-proven hepatic dysfunction as well as frequent syncopal attacks 3 months before admission to our hospital. One month later, she developed urinary retention and distal limb numbness. Upon admission, her neurological examination showed reduced limb tendon reflexes, glove and stocking-type numbness, and diminished senses of touch, temperature, pain, and distal leg vibration and position. Serum cytomegalovirus (CMV) IgM antibody and CMV IgG antibody were elevated on admission, and both decreased thereafter, confirming CMV infection...
August 31, 2016: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/27452908/adenoviral-ccn-gene-transfers-induce-in-vitro-and-in-vivo-endoplasmic-reticulum-stress-and-unfolded-protein-response
#18
Erawan Borkham-Kamphorst, Bettina Therese Steffen, Eddy Van de Leur, Lidia Tihaa, Ute Haas, Marius M Woitok, Steffen K Meurer, Ralf Weiskirchen
The endoplasmic reticulum (ER) is primarily recognized as the site of synthesis and folding of secreted membrane-bound and certain organelle-targeted proteins. Optimum protein folding requires several factors, including ATP, Ca(2+) and an oxidizing environment to allow disulphide-bond formation. ER is highly sensitive to stress that perturb cellular energy levels, the redox state or the Ca(2+) concentration. Such stresses reduce the protein folding capacity of the ER, resulting in the accumulation and aggregation of unfolded proteins, a condition referred to as unfolded protein response (UPR)...
November 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27452473/distinct-metabolic-requirements-of-exhausted-and-functional-virus-specific-cd8%C3%A2-t-cells-in-the-same-host
#19
Anna Schurich, Laura J Pallett, Danyal Jajbhay, Jessica Wijngaarden, Itziar Otano, Upkar S Gill, Navjyot Hansi, Patrick T Kennedy, Eleni Nastouli, Richard Gilson, Christian Frezza, Sian M Henson, Mala K Maini
T cells undergo profound metabolic changes to meet the increased energy demands of maintaining an antiviral response. We postulated that differences in metabolic reprogramming would shape the efficacy of CD8 T cells mounted against persistent viral infections. We found that the poorly functional PD-1(hi) T cell response against hepatitis B virus (HBV) had upregulated the glucose transporter, Glut1, an effect recapitulated by oxygen deprivation to mimic the intrahepatic environment. Glut1(hi) HBV-specific T cells were dependent on glucose supplies, unlike the more functional cytomegalovirus (CMV)-specific T cells that could utilize oxidative phosphorylation in the absence of glucose...
August 2, 2016: Cell Reports
https://www.readbyqxmd.com/read/27449440/valvular-cytomegalovirus-endocarditis
#20
Timothy J Stear, David Shersher, George J Kim, Douglas R Smego
Endocarditis is a rare presentation for cytomegalovirus (CMV) infection. We present the case of a 49-year-old man who underwent mitral and tricuspid valve replacement for valvular CMV endocarditis. The patient's past medical history was significant for human immunodeficiency virus, intravenous drug abuse, and chronic hepatitis B. During his clinical course, he was found to have tricuspid and mitral valve vegetations. After progressive valvular destruction despite antibiotic therapy, he underwent successful mitral and tricuspid valve replacement...
August 2016: Annals of Thoracic Surgery
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