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https://www.readbyqxmd.com/read/28431111/correction-of-abnormal-b-cell-subset-distribution-by-interleukin-6-receptor-blockade-in-polymyalgia-rheumatica
#1
Guillermo Carvajal Alegria, Valérie Devauchelle-Pensec, Yves Renaudineau, Alain Saraux, Jacques-Olivier Pers, Divi Cornec
Objectives.: The aim was to study lymphocyte subsets and circulating cytokines at diagnosis of PMR and after tocilizumab monotherapy. Methods.: Eighteen untreated patients with PMR were included in a prospective study and received 3-monthly tocilizumab infusions without glucocorticoids. Lymphocyte subset distribution was assessed by flow cytometry and serum cytokines were assayed by a 34-cytokine array and ELISA, at baseline and during follow-up. Baseline data were also compared with age- and sex-matched controls...
April 20, 2017: Rheumatology
https://www.readbyqxmd.com/read/28430007/the-feasibility-and-impact-of-prospective-medication-review-in-the-emergency-department
#2
Billy Sin, Kwong Lau, Richard Tong, Josel Ruiz, Kimberly Sarosky, Robert DiGregorio, Shalom Butel, Sylvie de Souza
OBJECTIVE: We evaluated the feasibility and impact of prospective medication review (PMR) in the emergency department (ED). METHODS: This was a retrospective cohort study of all nonadmitted ED patients who were prescribed medication orders by ED clinicians from September 2014 to September 2015 to determine the time intervals utilized during each step of the medication use process and quantify the number of interventions conducted by the pharmacist and cost avoidance accrued from the interventions...
January 1, 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28422921/population-based-estimate-of-trauma-related-deaths-for-law-enforcement-personnel-risks-for-death-are-higher-and-increasing-over-time
#3
Alexander L Eastman, Michael W Cripps, Kareem R Abdelfattah, Kenji Inaba, Thomas G Weiser, David A Spain, Kristan L Staudenmayer
OBJECTIVE: Trauma-related deaths remain an important public health problem. One group susceptible to death due to traumatic mechanisms is U.S. Law Enforcement (LE). We hypothesized that LE officers experienced a higher chance of violent death compared to the general U.S. population and that risks have increased over time. METHODS: The National Institute on Occupational Safety and Health (NIOSH) National Occupational Mortality Surveillance (NOMS) is a population-based survey of occupational deaths...
April 18, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28419623/cognitive-component-of-psychomotor-retardation-in-unipolar-and-bipolar-depression-is-verbal-fluency-a-relevant-marker-impact-of-repetitive-transcranial-stimulation
#4
Véronique Thomas-Ollivier, Emmanuelle Foyer, Samuel Bulteau, Anne Pichot, Pierre Valriviere, Anne Sauvaget, Thibault Deschamps
AIMS: In the literature, psychomotor retardation (PMR) is increasingly highlighted as a relevant marker for depression. Currently, we chose to focus on the fluency capacities as an evaluation of the frontal lobes functioning to reach a better understanding of cognitive and neurobiological mechanisms involved in PMR in depression. The aims of this study were 1) to explore the cognitive component of PMR through the analysis of Verbal Fluency (VF) performance in unipolar and bipolar depression; 2) to examine whether a repetitive transcranial magnetic stimulation (rTMS) treatment can improve concomitantly the RPM and VF capacities, as a relevant marker characteristic of the cognitive component of PMR...
April 17, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28418359/-a-rare-concurrence-of-polymyalgia-rheumatica-and-aa-amyloidosis
#5
S G Radenska-Lopovok, O N Kotenko, N F Frolova, A I Zagrebneva, E S Stolyarevich, E V Volodina, V I Chervinko, E V Kryukov, M L Zubkin
Polymyalgia rheumatica (PMR) is a rare chronic inflammatory disease. It predominantly affects the elderly. The disease has a slow onset, pain and stiffness in the muscles of the shoulder and pelvic girdle, fever, weight loss, and a high acute-phase inflammatory response. The disease is concurrent with giant cell arteritis in a quarter of cases, which allows some authors to consider them as two different manifestations of the same pathological process. The kidneys are rarely involved. This disease is rarely complicated by AA amyloidosis...
2017: Arkhiv Patologii
https://www.readbyqxmd.com/read/28414060/dietary-protein-content-alters-both-male-and-female-contributions-to-drosophila-melanogaster-female-post-mating-response-traits
#6
Janna N Schultzhaus, Ginger E Carney
Males transfer sperm, proteins and other molecules to females during mating. In Drosophila melanogaster, these molecules contribute to the induction of egg maturation, ovulation, oviposition, sperm storage and changes in female receptivity. This suite of physiological and behavioral changes is referred to as the female post-mating response (PMR). Protein is a necessary macronutrient for both male and female reproduction, but imbalances in protein content can decrease reproductive potential. Dietary protein affects the production of proteins in the male ejaculate that are important for induction of the PMR, and female fecundity increases with dietary protein while lifetime mating rate decreases...
April 13, 2017: Journal of Insect Physiology
https://www.readbyqxmd.com/read/28409375/fluoroscopy-guided-gastric-peroral-endoscopic-pyloromyotomy-g-poem-a-more-reliable-and-efficient-method-for-treatment-of-refractory-gastroparesis
#7
H B Xue, H Z Fan, X M Meng, S Cristofaro, P Mekaroonkamol, S Dacha, L Y Li, X L Fu, S H Zhan, Q Cai
INTRODUCTION: Prior studies show promising results of the gastric peroral endoscopic pyloromyotomy (G-POEM) procedure for treatment of refractory gastroparesis. One major technical challenge involved in this procedure is identifying the pyloric muscular ring (PMR). The aim of this study is to establish a reliable method for identification of the PMR during G-POEM. METHODS: Fluoroscopy-guided G-POEM was performed by placing an endoclip at the 9 to 11'o clock position at the pylorus for identification of PMR...
April 13, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28405475/modified-release-prednisone-for-polymyalgia-rheumatica-a-multicentre-randomised-active-controlled-double-blind-parallel-group-study
#8
Maurizio Cutolo, Michael Hopp, Stefan Liebscher, Bhaskar Dasgupta, Frank Buttgereit
OBJECTIVE: To assess the efficacy and safety of modified-release (MR) versus immediate-release (IR) prednisone in newly diagnosed glucocorticoid (GC)-naïve patients with polymyalgia rheumatica (PMR). METHODS: Patients were randomised to double-blind MR prednisone (taken at approximately 22:00) or IR prednisone (taken in the morning), 15 mg/day for 4 weeks. The primary end point was complete response rate (≥70% reduction in PMR visual analogue scale, duration of morning stiffness and C reactive protein (CRP) (or CRP <2× upper limit of normal (ULN))) at week 4...
2017: RMD Open
https://www.readbyqxmd.com/read/28347377/a-pilot-evaluation-of-a-strengths-based-cbt-intervention-module-with-college-students
#9
Philipp Pascal Victor, Tobias Teismann, Ulrike Willutzki
BACKGROUND: Interventions focusing on positive experiences have moderate effects on distress, protective factors and quality of life. AIMS: To evaluate the 'Personal Model of Resilience' (PMR) intervention by Padesky and Mooney (2012) with a focus on resilience strategies the person already possesses. METHOD: In a pre-post design, intervention and control samples of college students (n = 53) are compared with regard to distress, protective factors and quality of life...
March 28, 2017: Behavioural and Cognitive Psychotherapy
https://www.readbyqxmd.com/read/28324118/early-onset-polymyalgia-rheumatica-two-rare-cases-under-age-of-50
#10
Jinyoung Park, Duk Hyun Sung
Polymyalgia rheumatica (PMR) is almost an exclusive disease of adults over the age of 50, and only a few cases have been reported. Two 46-year-old females visited our locomotor pain clinic with multiple joint pain with increased acute phase reactants. Rheumatologic markers, and HLA-B27 were checked. Serum protein electrophoresis and serum immunofixation electrophoresis, imaging studies including plane image, sonography, and magnetic resonance image was done. (18)F-Fludeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) showed characteristic findings of PMR, without evidences of sacroiliitis...
March 21, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28323463/injury-mortality-in-individuals-with-autism
#11
Joseph Guan, Guohua Li
OBJECTIVES: To examine epidemiological patterns of injury fatalities in individuals with a diagnosis of autism. METHODS: We identified individuals with a diagnosis of autism who died between 1999 and 2014 by screening causes of death in the multiple cause-of-death data files in the National Vital Statistics System based on the International Classification of Diseases, 10th Revision, code F84.0. We used the general US population as the reference to calculate proportionate mortality ratios (PMRs) and 95% confidence intervals (CIs)...
May 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28299429/anther-preferential-expressing-gene-pmr-is-essential-for-the-mitosis-of-pollen-development-in-rice
#12
Yaqin Liu, Ya Xu, Sheng Ling, Shasha Liu, Jialing Yao
Phenotype identification, expression examination, and function prediction declared that the anther-preferential expressing gene PMR may participate in regulation of male gametophyte development in rice. Male germline development in flowering plants produces the pair of sperm cells for double fertilization and the pollen mitosis is a key process of it. Although the structural features of male gametophyte have been defined, the molecular mechanisms regulating the mitotic cell cycle are not well elucidated in rice...
March 15, 2017: Plant Cell Reports
https://www.readbyqxmd.com/read/28295582/case-report-and-review-of-nonischemic-spontaneous-papillary-muscle-rupture-reports-between-2000-and-2015
#13
Pishoy Gouda, Lisa Weilovitch, Ronak Kanani, Bryan Har
Spontaneous papillary muscle rupture (PMR) is a rare cardiovascular emergency. We present a 63-year-old male who presents with acute dyspnea who was found to have an anterior PMR, with no evidence of coronary artery disease, infection, or trauma. A review of cases of nonischemic spontaneous PMR published in 2000-2015 identified 11 additional cases of spontaneous PMR. Posterior and anterior papillary muscles involvement was identified in 54.5% and 45.5% of cases, respectively. Rapid identification due to advances in imaging modalities and improved surgical management has led to optimal outcomes in patients with spontaneous PMR...
March 14, 2017: Echocardiography
https://www.readbyqxmd.com/read/28293635/semiquantitative-evaluation-of-extrasynovial-soft-tissue-inflammation-in-the-shoulders-of-patients-with-polymyalgia-rheumatica-and-elderly-onset-rheumatoid-arthritis-by-power-doppler-ultrasound
#14
Takeshi Suzuki, Ryochi Yoshida, Akiko Okamoto, Yu Seri
Objectives. To develop a scoring system for evaluating the extrasynovial soft tissue inflammation of the shoulders in patients with polymyalgia rheumatica (PMR) and elderly-onset rheumatoid arthritis with PMR-like onset (pm-EORA) using ultrasound. Methods. We analyzed stored power Doppler (PD) images obtained by the pretreatment examination of 15 PMR patients and 15 pm-EORA patients. A semiquantitative scoring system for evaluating the severity of PD signals adjacent to the anterior aspect of the subscapularis tendon was designed...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28283812/behavioral-treatments-for-post-traumatic-headache
#15
REVIEW
Felicia Fraser, Yuka Matsuzawa, Yuen Shan Christine Lee, Mia Minen
PURPOSE OF REVIEW: Post-traumatic headache (PTH) is a common headache type after traumatic brain injury (TBI). There are no FDA approved medications for PTH, and it is unknown how medications can affect the brain's ability to recover from TBI. Thus, we sought to examine the biopsychosocial factors that influence PTH and the non-pharmacologic treatments studied for headache treatment. We also sought to determine if there is literature examining whether the non-pharmacologic treatments influence the biopsychosocial factors...
May 2017: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/28276953/risk-of-ocular-manifestations-in-patients-with-giant-cell-arteritis-a-nationwide-study-in-sweden
#16
J Ji, I Dimitrijevic, J Sundquist, K Sundquist, B Zöller
OBJECTIVE: No large-scale nationwide study has determined the risk of ocular manifestations in patients with giant cell arteritis (GCA). The aim was to study the incidence and risk factors of ocular manifestations in patients with GCA in Sweden. METHOD: A national cohort was created by linking Swedish nationwide registers. GCA patients were identified from the Swedish Hospital Inpatient and Outpatient Registers between 2002 and 2010, and were followed until the development of ocular manifestations...
February 22, 2017: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/28265227/pet-ct-imaging-in-polymyalgia-rheumatica-praepubic-18-f-fdg-uptake-correlates-with-pectineus-and-adductor-longus-muscles-enthesitis-and-with-tenosynovitis
#17
Zdenek Rehak, Andrea Sprlakova-Pukova, Zbynek Bortlicek, Zdenek Fojtik, Tomas Kazda, Marek Joukal, Renata Koukalova, Jiri Vasina, Jana Eremiasova, Petr Nemec
BACKGROUND: The role of (18)F-fluorodeoxyglucose positron emission computed tomography ((18)F-FDG PET/CT) is increasing in the diagnosis of polymyalgia rheumatica (PMR), one of the most common inflammatory rheumatic diseases. In addition to other locations, increased (18)F-FDG accumulation has been detected in the praepubic region in some patients. However, a deeper description and pathophysiological explanation of this increased praepubic accumulation has been lacking. The aim of the presented study is to confirm a decrease in praepubic (18)F-FDG accumulation in response to therapy and to describe potential correlations to other (18)F-FDG PET/CT scan characteristics during the course of disease...
March 1, 2017: Radiology and Oncology
https://www.readbyqxmd.com/read/28264228/assessment-of-2012-eular-acr-new-classification-criteria-for-polymyalgia-rheumatica-in-japanese-patients-diagnosed-using-bird-s-criteria
#18
Kiyoshi Matsui, Momo Maruoka, Takahiro Yoshikawa, Naoaki Hashimoto, Mika Nogami, Masahiro Sekiguchi, Naoto Azuma, Masayasu Kitano, Shinichiro Tsunoda, Hajime Sano
AIM: The 2012 European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) classification criteria for polymyalgia rheumatica (PMR) were published in 2012. The present study aimed to assess the 2012 EULAR/ACR classification criteria for PMR in Japanese patients diagnosed with PMR using Bird's criteria. METHODS: The study included 75 patients diagnosed using Bird's criteria. The patients were divided into fulfilled and not-fulfilled groups according to whether they met the 2012 EULAR/ACR classification criteria for PMR...
March 6, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28253315/introducing-malaria-rapid-diagnostic-tests-in-private-medicine-retail-outlets-a-systematic-literature-review
#19
Theodoor Visser, Katia Bruxvoort, Kathleen Maloney, Toby Leslie, Lawrence M Barat, Richard Allan, Evelyn K Ansah, Jennifer Anyanti, Ian Boulton, Siân E Clarke, Jessica L Cohen, Justin M Cohen, Andrea Cutherell, Caitlin Dolkart, Katie Eves, Günther Fink, Catherine Goodman, Eleanor Hutchinson, Sham Lal, Anthony Mbonye, Obinna Onwujekwe, Nora Petty, Julie Pontarollo, Stephen Poyer, David Schellenberg, Elizabeth Streat, Abigail Ward, Virginia Wiseman, Christopher J M Whitty, Shunmay Yeung, Jane Cunningham, Clare I R Chandler
BACKGROUND: Many patients with malaria-like symptoms seek treatment in private medicine retail outlets (PMR) that distribute malaria medicines but do not traditionally provide diagnostic services, potentially leading to overtreatment with antimalarial drugs. To achieve universal access to prompt parasite-based diagnosis, many malaria-endemic countries are considering scaling up malaria rapid diagnostic tests (RDTs) in these outlets, an intervention that may require legislative changes and major investments in supporting programs and infrastructures...
2017: PloS One
https://www.readbyqxmd.com/read/28237774/identification-of-urine-tauro-%C3%AE-muricholic-acid-as-a-promising-biomarker-in-polygoni-multiflori-radix-induced-hepatotoxicity-by-targeted-metabolomics-of-bile-acids
#20
Dong-Sheng Zhao, Li-Long Jiang, Ya-Xi Fan, Lei-Chi Dong, Jiang Ma, Xin Dong, Xiao-Jun Xu, Ping Li, Hui-Jun Li
Polygoni Multiflori Radix (PMR) has been widely used as a tonic for centuries. However, hepatotoxicity cases linked to PMR have been frequently reported and appropriate biomarkers for clinical diagnosis are currently lacking. Here, an approach using UPLC-QqQ/MS-based targeted metabolomics of bile acids (BAs) complemented with biochemistry and histopathology was applied to characterize the development and recovery processes of PMR-induced hepatotoxicity in rats and to identify biomarkers. The expression of bile salt export pump (Bsep) and sodium taurocholate cotransporting polypeptide (Ntcp) were evaluated to investigate the underlying mechanism...
February 24, 2017: Food and Chemical Toxicology
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