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https://www.readbyqxmd.com/read/28634698/association-between-characteristics-of-pain-and-stiffness-and-the-functional-status-of-patients-with-incident-polymyalgia-rheumatica-from-primary-care
#1
A Cawley, J A Prior, S Muller, T Helliwell, S L Hider, B Dasgupta, K Barraclough, C D Mallen
This paper aims to examine the relationship between different characteristics of pain and stiffness and the functional status of patients with newly diagnosed polymyalgia rheumatica (PMR). Baseline analysis of an inception cohort study was conducted. Patients aged ≥18 years, with a new diagnosis of PMR were recruited from 382 English general practices. Participants were mailed a baseline questionnaire, including separate pain and stiffness manikins and numerical rating scales (NRS), a question on their ability to raise their arms above their head and the modified Health Assessment Questionnaire (mHAQ) to examine participants' functional status...
June 20, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28629535/enhanced-absorption-and-inhibited-metabolism-of-emodin-by-2-3-5-4-tetrahydroxystilbene-2-o-%C3%AE-d-glucopyranoside-possible-mechanisms-for-polygoni-multiflori-radix-induced-liver-injury
#2
Qiong Yu, Li-Long Jiang, Na Luo, Ya-Xi Fan, Jiang Ma, Ping Li, Hui-Jun Li
Polygoni Multiflori Radix (PMR) has been commonly used as a tonic in China for centuries. However, PMR-associated hepatotoxicity is becoming a safety issue. In our previous in vivo study, an interaction between stilbenes and anthraquinones has been discovered and a hypothesis is proposed that the interaction between stilbene glucoside-enriching fraction and emodin may contribute to the side effects of PMR. To further support our previous in vivo results in rats, the present in vitro study was designed to evaluate the effects of 2, 3, 5, 4'-tetrahydroxystilbene-2-O-β-D-glucopyranoside (TSG) on the cellular absorption and human liver microsome metabolism of emodin...
June 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28626488/hepatotoxicity-in-rats-induced-by-aqueous-extract-of-polygoni-multiflori-radix-root-of-polygonum-multiflorum-related-to-the-activity-inhibition-of-cyp1a2-or-cyp2e1
#3
Deng-Ke Li, Jing Chen, Zhen-Zhen Ge, Zhen-Xiao Sun
The objective of this study is to investigate the relationship between the hepatotoxicity induced by Polygoni Multiflori Radix (PMR, root of Polygonum multiflorum Thunb., He Shou Wu) and the activity of CYP1A2 or CYP2E1 in the rat liver. Levels of rat serum transaminases ALT and AST were not altered but the activity of CYP1A2 or CYP2E1 in the rat liver was significantly inhibited after oral administration of aqueous extract of PMR under the experimental dosage. However, levels of ALT and AST were significantly increased and the activity of CYP1A2 or CYP2E1 was significantly decreased after injection of specific inhibitor for CYP1A2 or CYP2E1 combined with oral administration of aqueous extract of PMR, especially under the repeated treatment over interval times...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28617735/evaluating-the-effectiveness-of-using-a-progressive-muscle-relaxation-technique-on-the-self-efficacy-of-breastfeeding-in-mothers-with-preterm-infants
#4
Soheila Karbandi, Seyedeh Maryam Hosseini, Seyedeh Asieh Hosseini, Farshad Sadeghi, Maryam Hesari, Reza Masoudi
BACKGROUND: Breast milk is a God-given gift that conveys a mother's love and compassion and that is made according to the needs and age of the child. Mothers who are interested in the welfare of their newborns tend to breastfeed their children. Training programs have been shown to improve breastfeeding self-efficacy in terms of both duration and amount. PURPOSE: The aim of this study was to evaluate the effect of using the progressive muscle relaxation (PMR) technique on the self-efficacy of breastfeeding in mothers with preterm infants...
June 14, 2017: Journal of Nursing Research: JNR
https://www.readbyqxmd.com/read/28600350/rheumatoid-arthritis-and-polymyalgia-rheumatica-occurring-after-immune-checkpoint-inhibitor-treatment
#5
Rakiba Belkhir, Sébastien Le Burel, Laetitia Dunogeant, Aurélien Marabelle, Antoine Hollebecque, Benjamin Besse, Alexandra Leary, Anne-Laure Voisin, Clémence Pontoizeau, Laetitia Coutte, Edouard Pertuiset, Gaël Mouterde, Olivier Fain, Olivier Lambotte, Xavier Mariette
OBJECTIVES: Immune checkpoint inhibitors (ICIs) targeting cytotoxic T-lymphocyte-associated protein 4 and programmed cell death protein 1 (PD-1) have demonstrated improved survival for multiple cancers. However, these new drug classes have led to increased immune-related adverse events (IrAE). Rheumatic IrAEs have not been well described in clinical trials. We report here cases of rheumatoid arthritis (RA) and polymyalgia rheumatica (PMR) occurring after ICI treatment. METHODS: This was a retrospective study of patients receiving an ICI in whom symptoms of arthritis or arthralgia developed and revealed a diagnosis of RA or PMR...
June 9, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28583280/clinical-value-of-fdg-pet-ct-for-the-evaluation-of-rheumatic-diseases-rheumatoid-arthritis-polymyalgia-rheumatica-and-relapsing-polychondritis
#6
REVIEW
Kazuo Kubota, Hiroyuki Yamashita, Akio Mimori
FDG is a tracer for visualizing glucose metabolism. PET/CT using FDG is widely used for the diagnosis of cancer, because glycolysis is elevated in cancer cells. Similarly, active inflammatory tissue also exhibits elevated glucose metabolism because of glycolysis in activated macrophages and proliferating fibroblasts. Elevated FDG uptake by active inflammatory tissues, such as those affected by arthritis, vasculitis, lymphadenitis, and chondritis, has enabled the diagnosis of inflammatory diseases using FDG-PET/CT...
July 2017: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/28580403/damage-accumulation-of-bovine-bone-under-variable-amplitude-loads
#7
Abbey M Campbell, Michelle L Cler, Carolyn P Skurla, Joseph J Kuehl
Stress fractures, a painful injury, are caused by excessive fatigue in bone. This study on damage accumulation in bone sought to determine if the Palmgren-Miner rule (PMR), a well-known linear damage accumulation hypothesis, is predictive of fatigue failure in bone. An electromagnetic shaker apparatus was constructed to conduct cyclic and variable amplitude tests on bovine bone specimens. Three distinct damage regimes were observed following fracture. Fractures due to a low cyclic amplitude loading appeared ductile ( 4000 μϵ), brittle due to high cyclic amplitude loading (> 9000 μϵ), and a combination of ductile and brittle from mid-range cyclic amplitude loading (6500 -6750 μϵ)...
December 2016: Bone Reports
https://www.readbyqxmd.com/read/28577898/the-nexus-of-hair-corticosterone-level-immunocompetence-metabolic-rates-and-overwinter-survival-in-the-root-vole-microtus-oeconomus
#8
Aneta Książek, Karol Zub, Paulina A Szafrańska, Monika Wieczorek, Marek Konarzewski
Although corticosterone (CORT) regulates many physiological mechanisms, the associations between CORT levels, immunocompetence, energy expenditures and overwinter survival have not been examined. Here, we studied individual variation in CORT level extracted from hair, immunocompetence quantified as the neutrophil-to-lymphocyte (N/L) ratio, total white blood cells (WBC) and natural antibody levels (NAbs), along with the resting (RMR) and peak metabolic rates (PMR) and mortality during three consecutive winter seasons in a natural population of the root vole, Microtus oeconomus...
May 31, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28575065/does-published-research-on-non-communicable-disease-ncd-in-arab-countries-reflect-ncd-disease-burden
#9
Abla M Sibai, Neil V Singh, Samer Jabbour, Shadi Saleh, Sawsan Abdulrahim, Farah Naja, Soha Yazbek
OBJECTIVES: To review trends in non-communicable (NCD) research output in the Arab region, in terms of quantity and quality, study design, setting and focus. We also examined differences by time and place, and assessed gaps between research output and NCD burden. METHODS: A scoping review of a total of 3,776 NCD-related reports published between 2000 and 2013 was conducted for seven Arab countries. Countries were selected to represent diverse socio-economic development levels in the region: Regression analyses were used to assess trends in publications over time and by country...
2017: PloS One
https://www.readbyqxmd.com/read/28573368/how-common-is-depression-in-patients-with-polymyalgia-rheumatica
#10
Arani Vivekanantham, Milica Blagojevic-Bucknall, Kris Clarkson, John Belcher, Christian D Mallen, Samantha L Hider
Depression is common in inflammatory disorders such as rheumatoid arthritis and systemic lupus erythematosus and negatively impacts on outcomes. Given the long-term nature of polymyalgia rheumatica (PMR) and its glucocorticoid treatment, these patients may be at an increased risk of depression, although few studies exist to date. This study aimed to investigate the prevalence of, and factors associated with, depression in PMR patients. Prevalent PMR patients (with a first diagnostic code for PMR in the last 3 years) were mailed a postal questionnaire (n = 704) examining PMR symptoms, glucocorticoid use and patient reported comorbidities...
June 1, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28567535/immune-mediated-syndromes-following-intravenous-bisphosphonate-therapy
#11
Noa Markovits, Ronen Loebstein, Ilan Bank
OBJECTIVES: Intravenous (IV) infusion of aminobisphosphonates (ABP) induces cytokine release by peripheral blood Vγ9δ2 T cells, resulting in an immediate short-term inflammatory response in up to 50% of patients. We evaluated possible long-term pro-inflammatory effects of IV ABP. METHODS: Retrospective case-series study from one rheumatology specialist's clinic. 2261 electronic charts were reviewed for administration of 'zoledronate' or different brand names of zoledronic acid, and relevant clinical data was retrieved for patients who had received the infusion...
May 31, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28560714/clinical-presentation-and-echocardiographic-diagnosis-of-postinfarction-papillary-muscle-rupture-a-review-of-22-cases
#12
Bradley W Ternus, Sunil Mankad, William D Edwards, Rekha Mankad
BACKGROUND: Acute myocardial infarctions (AMI) continue to be common in the United States. Mechanical complications of AMI can lead to cardiogenic shock (CS) and death. The aim of this study was to review the cases of papillary muscle ruptures in the setting of myocardial infarctions at a tertiary care center, with a focus on the clinical presentation and echocardiographic diagnosis. METHODS: This was a retrospective study from January 1, 2000 through December 31, 2014...
May 30, 2017: Echocardiography
https://www.readbyqxmd.com/read/28551169/contemporary-prevalence-estimates-for-giant-cell-arteritis-and-polymyalgia-rheumatica-2015
#13
Cynthia S Crowson, Eric L Matteson
OBJECTIVE: There are no estimates of the prevalence of giant cell arteritis (GCA) or polymyalgia rheumatica (PMR) in a US population in the current millennium. The purpose of this study was to estimate the 2015 prevalence of GCA and PMR in a US population-based setting. METHODS: Cohorts of incident GCA in 1950-2009 and incident PMR in 1970-2014 were previously identified among residents of Olmsted County, Minnesota. Prevalence estimates were obtained from the age-, sex-, and calendar year-specific incidence rates and adjusted to the US white 2010 population aged ≥50 years...
April 7, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28536934/-off-label-biological-therapies-in-patients-with-large-vessel-vasculitis-and-or-polymyalgia-rheumatica-safety-and-efficacy-analysis-of-a-nationwide-german-registry-graid2
#14
J C Henes, H Schulze-Koops, M Witt, H P Tony, F Mueller, M Grunke, M Czihal, T Dörner, F Proft
OBJECTIVE: To evaluate the safety and clinical outcome of biological therapies in patients with large vessel vasculitis (LVV) or polymyalgia rheumatica (PMR) refractory to standard of care therapy in a real-life setting in Germany. METHODS: GRAID 2 (German Registry in Autoimmune Diseases 2) is a retrospective, noninterventional, multicenter registry collecting data from all patients with inflammatory rheumatic diseases refractory to conventional therapy treated with an initial off-label biological between August 2006 and December 2013...
May 23, 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/28535619/prevalence-and-incidence-of-osteoporotic-fractures-in-patients-on-long-term-glucocorticoid-treatment-for-rheumatic-diseases-the-glucocorticoid-induced-osteoporosis-tool-giotto-study
#15
M Rossini, O Viapiana, M Vitiello, N Malavolta, G La Montagna, S Maddali Bongi, O Di Munno, R Nuti, C U Manzini, C Ferri, L Bogliolo, A Mathieu, F Cantatore, A Del Puente, M Muratore, W Grassi, B Frediani, G Saviola, P Delvino, L Mirone, G Ferraccioli, G Tripi, I Piazza, D Gatti
Osteoporosis and fractures are common and invalidating consequences of chronic glucorticoid (GC) treatment. Reliable information regarding the epidemiology of GC induced osteoporosis (GIOP) comes exclusively from the placebo group of randomized clinical trials while observational studies are generally lacking data on the real prevalence of vertebral fractures, GC dosage and primary diagnosis. The objective of this study was to evaluate the prevalence and incidence of osteoporotic fractures and to identify their major determinants (primary disease, GC dosage, bone mineral density, risk factors, specific treatment for GIOP) in a large cohort of consecutive patients aged >21 years, on chronic treatment with GC (≥5 mg prednisone - PN - equivalent) and attending rheumatology centers located all over Italy...
May 22, 2017: Reumatismo
https://www.readbyqxmd.com/read/28534604/the-influence-of-expectations-on-improvements-in-pain-and-function-in-patients-with-neck-back-shoulder-complaints-a-cohort-study
#16
Sigrid Skatteboe, Cecilie Røe, Morten W Fagerland, Lars-Petter Granan
BACKGROUND: In musculoskeletal research, patients' expectations have recently received increased attention. However, few prospective studies have investigated these expectations or their prognostic significance and possible clinical value. AIM: To investigate the influence of patients' expectations on improvements in pain and functional status six months after an outpatient physical medicine assessment. DESIGN: A prospective cohort study. SETTING: Physical Medicine and Rehabilitation (PMR) outpatient clinic...
May 23, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28521434/detection-of-spg20-gene-promoter-methylated-dna-as-a-novel-epigenetic-biomarker-in-plasma-for-colorectal-cancer-diagnosis-using-the-methylight-method
#17
Nayebali Rezvani, Reza Alibakhshi, Assad Vaisi-Raygani, Homayoon Bashiri, Massoud Saidijam
Aberrant promoter methylation of genes is a common epigenetic alteration in colorectal cancer (CRC). In the present study, spastic paraplegia 20 (SPG20) promoter-methylated DNA, as a potential diagnostic biomarker, was investigated in plasma and tumor tissue samples from patients with CRC. To the best of our knowledge, the quantification of SPG20 promoter-methylated DNA in plasma samples remains unreported. SPG20 promoter methylation was investigated in 32 paired tumor and healthy adjacent tissues, 37 plasma samples from patients with CRC, and in 37 plasma samples from a healthy control group, using the MethyLight method...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28508663/-18-f-fdg-pet-ct-in-polymyalgia-rheumatica-a-pictorial-review
#18
Zdenek Rehak, Andrea Sprlakova-Pukova, Tomas Kazda, Zdenek Fojtik, Lenka Vargova, Petr Nemec
Polymyalgia rheumatica (PMR) is one of the inflammatory rheumatic diseases that can potentially be detected by PET/CT. High (18)F-FDG accumulation around the shoulders, sternoclavicular and hip joints are the most common pre-treatment features of PMR patients. Another common sign is increased (18)F-FDG uptake in extraarticular regions between columnal spinous processes, near ischial tuberosities and in the praepubic area. Some patients also present with high (18)F-FDG uptake in main arteries, corresponding to the characteristics of giant cell arteritis...
May 16, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28494286/slurry-photocatalytic-membrane-reactor-technology-for-removal-of-pharmaceutical-compounds-from-wastewater-towards-cytostatic-drug-elimination
#19
REVIEW
Raphael Janssens, Mrinal Kanti Mandal, Kashyap Kumar Dubey, Patricia Luis
The potential of photocatalytic membrane reactors (PMR) to degrade cytostatic drugs is presented in this work as an emerging technology for wastewater treatment. Cytostatic drugs are pharmaceutical compounds (PhCs) commonly used in cancer treatment. Such compounds and their metabolites, as well as their degraded by-products have genotoxic and mutagenic effects. A major challenge of cytostatic removal stands in the fact that most drugs are delivered to ambulant patients leading to diluted concentration in the municipal waste...
December 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28490472/-18-f-fdg-pet-ct-for-very-early-response-evaluation-predicts-ct-response-in-erlotinib-treated-nsclc-patients-a-comparison-of-assessment-methods
#20
Joan Fledelius, Anne Winther-Larsen, Azza Ahmed Khalil, Catharina Mølgaard Bylov, Karin Hjorthaug, Aksel Bertelsen, Jørgen Frøkiær, Peter Meldgaard
The purpose of this study was to determine which method for early response evaluation with (18)F-fluoro-D-glucose positron emission tomography combined with whole body computed tomography ((18)F-FDG-PET/CT) performed most optimal for prediction of response on a later CT-scan in erlotinib treated non-small cell lung cancer (NSCLC) patients. Methods:(18)F-FDG-PET/CT scans were performed prior to and after 7-10 days of erlotinib treatment in 50 NSCLC patients. The scans were evaluated using a qualitative approach and various semi-quantitative methods including percentage change in Standardized Uptake values, lean body mass corrected (SUL) SULpeak, SULmax and Total Lesion Glycolysis (TLG)...
May 10, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
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