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https://www.readbyqxmd.com/read/28521434/detection-of-spg20-gene-promoter-methylated-dna-as-a-novel-epigenetic-biomarker-in-plasma-for-colorectal-cancer-diagnosis-using-the-methylight-method
#1
Nayebali Rezvani, Reza Alibakhshi, Assad Vaisi-Raygani, Homayoon Bashiri, Massoud Saidijam
Aberrant promoter methylation of genes is a common epigenetic alteration in colorectal cancer (CRC). In the present study, spastic paraplegia 20 (SPG20) promoter-methylated DNA, as a potential diagnostic biomarker, was investigated in plasma and tumor tissue samples from patients with CRC. To the best of our knowledge, the quantification of SPG20 promoter-methylated DNA in plasma samples remains unreported. SPG20 promoter methylation was investigated in 32 paired tumor and healthy adjacent tissues, 37 plasma samples from patients with CRC, and in 37 plasma samples from a healthy control group, using the MethyLight method...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28508663/-18-f-fdg-pet-ct-in-polymyalgia-rheumatica-a-pictorial-review
#2
Zdenek Rehak, Andrea Sprlakova-Pukova, Tomas Kazda, Zdenek Fojtik, Lenka Vargova, Petr Nemec
Polymyalgia rheumatica (PMR) is one of the inflammatory rheumatic diseases that can potentially be detected by PET/CT. High (18)F-FDG accumulation around the shoulders, sternoclavicular and hip joints are the most common pre-treatment features of PMR patients. Another common sign is increased (18)F-FDG uptake in extraarticular regions between columnal spinous processes, near ischial tuberosities and in the praepubic area. Some patients also present with high (18)F-FDG uptake in main arteries, corresponding to the characteristics of giant cell arteritis...
May 16, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28494286/slurry-photocatalytic-membrane-reactor-technology-for-removal-of-pharmaceutical-compounds-from-wastewater-towards-cytostatic-drug-elimination
#3
REVIEW
Raphael Janssens, Mrinal Kanti Mandal, Kashyap Kumar Dubey, Patricia Luis
The potential of photocatalytic membrane reactors (PMR) to degrade cytostatic drugs is presented in this work as an emerging technology for wastewater treatment. Cytostatic drugs are pharmaceutical compounds (PhCs) commonly used in cancer treatment. Such compounds and their metabolites, as well as their degraded by-products have genotoxic and mutagenic effects. A major challenge of cytostatic removal stands in the fact that most drugs are delivered to ambulant patients leading to diluted concentration in the municipal waste...
May 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28490472/-18-f-fdg-pet-ct-for-very-early-response-evaluation-predicts-ct-response-in-erlotinib-treated-nsclc-patients-a-comparison-of-assessment-methods
#4
Joan Fledelius, Anne Winther-Larsen, Azza Ahmed Khalil, Catharina Mølgaard Bylov, Karin Hjorthaug, Aksel Bertelsen, Jørgen Frøkiær, Peter Meldgaard
The purpose of this study was to determine which method for early response evaluation with (18)F-fluoro-D-glucose positron emission tomography combined with whole body computed tomography ((18)F-FDG-PET/CT) performed most optimal for prediction of response on a later CT-scan in erlotinib treated non-small cell lung cancer (NSCLC) patients. Methods:(18)F-FDG-PET/CT scans were performed prior to and after 7-10 days of erlotinib treatment in 50 NSCLC patients. The scans were evaluated using a qualitative approach and various semi-quantitative methods including percentage change in Standardized Uptake values, lean body mass corrected (SUL) SULpeak, SULmax and Total Lesion Glycolysis (TLG)...
May 10, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28485353/occurrence-of-carcinoma-prostate-in-the-pune-metropolitan-region-a-5-year-study-from-2007-to-2011
#5
S S Bapat, B D Kashyapi
BACKGROUND: A retrospective study was carried out to know only the occurrence of carcinoma prostate (CAP) in the Pune Metropolitan Region (PMR) over a period of five years (January 01, 2007 to December 31, 2011). All the histopathological (HPE) reports of all prostate specimens were collected from 23 medical colleges, private institutions and stand-.alone HPE laboratories in PMR. MATERIALS AND METHODS: Four types of prostate specimens were examined - endoscopic resection, open prostatectomy, transrectal needle biopsy of prostate and prostate from the cystoprostatectomy specimen (surgery carried out for primary carcinoma bladder)...
October 2016: Indian Journal of Cancer
https://www.readbyqxmd.com/read/28484823/-prolonged-weaning-during-early-neurological-and-neurosurgical-rehabilitation-s2k-guideline-published-by-the-weaning-committee-of-the-german-neurorehabilitation-society-dgnr
#6
REVIEW
J D Rollnik, J Adolphsen, J Bauer, M Bertram, J Brocke, C Dohmen, E Donauer, M Hartwich, M D Heidler, V Huge, S Klarmann, S Lorenzl, M Lück, M Mertl-Rötzer, T Mokrusch, D A Nowak, T Platz, L Riechmann, F Schlachetzki, A von Helden, C W Wallesch, D Zergiebel, M Pohl
Prolonged weaning of patients with neurological or neurosurgery disorders is associated with specific characteristics, which are taken into account by the German Society for Neurorehabilitation (DGNR) in its own guideline. The current S2k guideline of the German Society for Pneumology and Respiratory Medicine is referred to explicitly with regard to definitions (e.g., weaning and weaning failure), weaning categories, pathophysiology of weaning failure, and general weaning strategies. In early neurological and neurosurgery rehabilitation, patients with central of respiratory regulation disturbances (e...
May 8, 2017: Der Nervenarzt
https://www.readbyqxmd.com/read/28481228/a-molecular-electron-density-theory-study-of-the-reactivity-of-azomethine-imine-in-3-2-cycloaddition-reactions
#7
Luis R Domingo, Mar Ríos-Gutiérrez
The electronic structure and the participation of the simplest azomethine imine (AI) in [3+2] cycloaddition (32CA) reactions have been analysed within the Molecular Electron Density Theory (MEDT) using Density Functional Theory (DFT) calculations at the MPWB1K/6-311G(d) level. Topological analysis of the electron localisation function reveals that AI has a pseudoradical structure, while the conceptual DFT reactivity indices characterises this three-atom-component (TAC) as a moderate electrophile and a good nucleophile...
May 6, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28480427/inhibitory-effect-of-emodin-on-raw-264-7-activated-with-double-stranded-rna-analogue-poly-i-c
#8
Young-Jin Kim, Ji Young Lee, Hyun-Ju Kim, Do-Hoon Kim, Tae Hee Lee, Mi Suk Kang, You-Kyung Choi, Hye Lim Lee, Jaieun Kim, Hyo-Jin An, And Wansu Park
BACKGROUND: Emodin (3-methyl-1, 6, 8-trihydroxyanthraquinone) is a compound which can be found in Polygoni Multiflori Radix (PMR). PMR is the root of Polygonum multiflorum. PMR is used to treat dizziness, spermatorrhea, sores, and scrofula as well as chronic malaria traditionally in China and Korea. The anti-tumor property of emodin was already reported. However, anti-viral activity of emodin on macrophages are not fully reported. MATERIALS AND METHODS: Effects of emodin on RAW 264...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28440334/trends-in-perinatal-mortality-and-its-risk-factors-in-japan-analysis-of-vital-registration-data-1979-2010
#9
Maaya Kita Sugai, Stuart Gilmour, Erika Ota, Kenji Shibuya
As Japan has achieved one of the lowest perinatal mortality rates (PMR), our study aims to estimate trends in and risk factors for perinatal mortality among singleton births in Japan. We used Japanese vital registration data to assess trends in and risk factors for perinatal outcomes between 1979 and 2010. Birth and death registration data were merged. An autoregressive integrated moving average model was fitted separately by sex to the PMR and the proportion of stillbirths. A multilevel Poisson regression model was used to estimate risk factors for perinatal mortality...
April 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28431111/correction-of-abnormal-b-cell-subset-distribution-by-interleukin-6-receptor-blockade-in-polymyalgia-rheumatica
#10
Guillermo Carvajal Alegria, Valérie Devauchelle-Pensec, Yves Renaudineau, Alain Saraux, Jacques-Olivier Pers, Divi Cornec
Objectives.: The aim was to study lymphocyte subsets and circulating cytokines at diagnosis of PMR and after tocilizumab monotherapy. Methods.: Eighteen untreated patients with PMR were included in a prospective study and received 3-monthly tocilizumab infusions without glucocorticoids. Lymphocyte subset distribution was assessed by flow cytometry and serum cytokines were assayed by a 34-cytokine array and ELISA, at baseline and during follow-up. Baseline data were also compared with age- and sex-matched controls...
April 20, 2017: Rheumatology
https://www.readbyqxmd.com/read/28430007/the-feasibility-and-impact-of-prospective-medication-review-in-the-emergency-department
#11
Billy Sin, Kwong Lau, Richard Tong, Josel Ruiz, Kimberly Sarosky, Robert DiGregorio, Shalom Butel, Sylvie de Souza
OBJECTIVE: We evaluated the feasibility and impact of prospective medication review (PMR) in the emergency department (ED). METHODS: This was a retrospective cohort study of all nonadmitted ED patients who were prescribed medication orders by ED clinicians from September 2014 to September 2015 to determine the time intervals utilized during each step of the medication use process and quantify the number of interventions conducted by the pharmacist and cost avoidance accrued from the interventions...
January 1, 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28422921/population-based-estimate-of-trauma-related-deaths-for-law-enforcement-personnel-risks-for-death-are-higher-and-increasing-over-time
#12
Alexander L Eastman, Michael W Cripps, Kareem R Abdelfattah, Kenji Inaba, Thomas G Weiser, David A Spain, Kristan L Staudenmayer
OBJECTIVE: Trauma-related deaths remain an important public health problem. One group susceptible to death due to traumatic mechanisms is U.S. Law Enforcement (LE). We hypothesized that LE officers experienced a higher chance of violent death compared to the general U.S. population and that risks have increased over time. METHODS: The National Institute on Occupational Safety and Health (NIOSH) National Occupational Mortality Surveillance (NOMS) is a population-based survey of occupational deaths...
April 18, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28419623/cognitive-component-of-psychomotor-retardation-in-unipolar-and-bipolar-depression-is-verbal-fluency-a-relevant-marker-impact-of-repetitive-transcranial-stimulation
#13
Véronique Thomas-Ollivier, Emmanuelle Foyer, Samuel Bulteau, Anne Pichot, Pierre Valriviere, Anne Sauvaget, Thibault Deschamps
AIMS: In the literature, psychomotor retardation (PMR) is increasingly highlighted as a relevant marker for depression. Currently, we chose to focus on the fluency capacities as an evaluation of the frontal lobes functioning to reach a better understanding of cognitive and neurobiological mechanisms involved in PMR in depression. The aims of this study were 1) to explore the cognitive component of PMR through the analysis of Verbal Fluency (VF) performance in unipolar and bipolar depression; 2) to examine whether a repetitive transcranial magnetic stimulation (rTMS) treatment can improve concomitantly the RPM and VF capacities, as a relevant marker characteristic of the cognitive component of PMR...
April 17, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28418359/-a-rare-concurrence-of-polymyalgia-rheumatica-and-aa-amyloidosis
#14
S G Radenska-Lopovok, O N Kotenko, N F Frolova, A I Zagrebneva, E S Stolyarevich, E V Volodina, V I Chervinko, E V Kryukov, M L Zubkin
Polymyalgia rheumatica (PMR) is a rare chronic inflammatory disease. It predominantly affects the elderly. The disease has a slow onset, pain and stiffness in the muscles of the shoulder and pelvic girdle, fever, weight loss, and a high acute-phase inflammatory response. The disease is concurrent with giant cell arteritis in a quarter of cases, which allows some authors to consider them as two different manifestations of the same pathological process. The kidneys are rarely involved. This disease is rarely complicated by AA amyloidosis...
2017: Arkhiv Patologii
https://www.readbyqxmd.com/read/28414060/dietary-protein-content-alters-both-male-and-female-contributions-to-drosophila-melanogaster-female-post-mating-response-traits
#15
Janna N Schultzhaus, Ginger E Carney
Males transfer sperm, proteins and other molecules to females during mating. In Drosophila melanogaster, these molecules contribute to the induction of egg maturation, ovulation, oviposition, sperm storage and changes in female receptivity. This suite of physiological and behavioral changes is referred to as the female post-mating response (PMR). Protein is a necessary macronutrient for both male and female reproduction, but imbalances in protein content can decrease reproductive potential. Dietary protein affects the production of proteins in the male ejaculate that are important for induction of the PMR, and female fecundity increases with dietary protein while lifetime mating rate decreases...
April 14, 2017: Journal of Insect Physiology
https://www.readbyqxmd.com/read/28409375/fluoroscopy-guided-gastric-peroral-endoscopic-pyloromyotomy-g-poem-a-more-reliable-and-efficient-method-for-treatment-of-refractory-gastroparesis
#16
H B Xue, H Z Fan, X M Meng, S Cristofaro, P Mekaroonkamol, S Dacha, L Y Li, X L Fu, S H Zhan, Q Cai
INTRODUCTION: Prior studies show promising results of the gastric peroral endoscopic pyloromyotomy (G-POEM) procedure for treatment of refractory gastroparesis. One major technical challenge involved in this procedure is identifying the pyloric muscular ring (PMR). The aim of this study is to establish a reliable method for identification of the PMR during G-POEM. METHODS: Fluoroscopy-guided G-POEM was performed by placing an endoclip at the 9 to 11'o clock position at the pylorus for identification of PMR...
April 13, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28405475/modified-release-prednisone-for-polymyalgia-rheumatica-a-multicentre-randomised-active-controlled-double-blind-parallel-group-study
#17
Maurizio Cutolo, Michael Hopp, Stefan Liebscher, Bhaskar Dasgupta, Frank Buttgereit
OBJECTIVE: To assess the efficacy and safety of modified-release (MR) versus immediate-release (IR) prednisone in newly diagnosed glucocorticoid (GC)-naïve patients with polymyalgia rheumatica (PMR). METHODS: Patients were randomised to double-blind MR prednisone (taken at approximately 22:00) or IR prednisone (taken in the morning), 15 mg/day for 4 weeks. The primary end point was complete response rate (≥70% reduction in PMR visual analogue scale, duration of morning stiffness and C reactive protein (CRP) (or CRP <2× upper limit of normal (ULN))) at week 4...
2017: RMD Open
https://www.readbyqxmd.com/read/28347377/a-pilot-evaluation-of-a-strengths-based-cbt-intervention-module-with-college-students
#18
Philipp Pascal Victor, Tobias Teismann, Ulrike Willutzki
BACKGROUND: Interventions focusing on positive experiences have moderate effects on distress, protective factors and quality of life. AIMS: To evaluate the 'Personal Model of Resilience' (PMR) intervention by Padesky and Mooney (2012) with a focus on resilience strategies the person already possesses. METHOD: In a pre-post design, intervention and control samples of college students (n = 53) are compared with regard to distress, protective factors and quality of life...
March 28, 2017: Behavioural and Cognitive Psychotherapy
https://www.readbyqxmd.com/read/28324118/early-onset-polymyalgia-rheumatica-two-rare-cases-under-age-of-50
#19
Jinyoung Park, Duk Hyun Sung
Polymyalgia rheumatica (PMR) is almost an exclusive disease of adults over the age of 50, and only a few cases have been reported. Two 46-year-old females visited our locomotor pain clinic with multiple joint pain with increased acute phase reactants. Rheumatologic markers, and HLA-B27 were checked. Serum protein electrophoresis and serum immunofixation electrophoresis, imaging studies including plane image, sonography, and magnetic resonance image was done. (18)F-Fludeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) showed characteristic findings of PMR, without evidences of sacroiliitis...
March 21, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28323463/injury-mortality-in-individuals-with-autism
#20
Joseph Guan, Guohua Li
OBJECTIVES: To examine epidemiological patterns of injury fatalities in individuals with a diagnosis of autism. METHODS: We identified individuals with a diagnosis of autism who died between 1999 and 2014 by screening causes of death in the multiple cause-of-death data files in the National Vital Statistics System based on the International Classification of Diseases, 10th Revision, code F84.0. We used the general US population as the reference to calculate proportionate mortality ratios (PMRs) and 95% confidence intervals (CIs)...
May 2017: American Journal of Public Health
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