keyword
MENU ▼
Read by QxMD icon Read
search

PAN

keyword
https://www.readbyqxmd.com/read/28538953/severe-onycholysis-and-eyelash-trichomegaly-following-use-of-new-selective-pan-fgfr-inhibitors
#1
Sarah Bétrian, Carlos Gomez-Roca, Emmanuelle Vigarios, Jean Pierre Delord, Vincent Sibaud
No abstract text is available yet for this article.
May 24, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28538855/-methodology-for-estimating-total-direct-costs-of-comprehensive-care-for-non-communicable-diseases
#2
Nancy Castillo, Miguel Malo, Nilda Villacres, José Chauca, Víctor Cornetero, Karin Roedel de Flores, Rafaela Tapia, Raúl Ríos
RESUMEN Diseases like diabetes mellitus (DM) and hypertension (HT) generate high costs and are the most common cause of mortality in the Americas. In the case of Peru, given demographic and epidemiological changes, particularly the alarming increase in overweight and obesity, the burden of these diseases is constantly increasing, resulting in the need to budget more financial resources to the health services. The total care costs of these diseases and their complications represent a financial burden that should be considered very carefully by health institutions when they draft their budgets...
January 2017: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/28538565/urinary-excretion-of-microrna-126-is-a-biomarker-for-hemangioma-proliferation
#3
Ayan Biswas, Xueliang Pan, Melissa Meyer, Savita Khanna, Sashwati Roy, Gregory Pearson, Richard Kirschner, Patricia Witman, Esteban Fernandez Faith, Chandan K Sen, Gayle M Gordillo
BACKGROUND: Hemangiomas are unique endothelial cell tumors that involute spontaneously, which makes interpreting their response to therapies difficult. The objective of this work was to identify a potential biomarker in the urine of children with infantile hemangiomas that would facilitate testing new therapies. METHODS: A prospective longitudinal study in children with hemangiomas and age-matched healthy controls was performed to determine whether microRNA-126, which is highly abundant in fetal endothelial cells, was more abundant in the urine of affected children...
June 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28538400/carbon-monoxide-releasing-molecule-2-suppresses-thrombomodulin-and-endothelial-protein-c-receptor-expression-of-human-umbilical-vein-endothelial-cells-induced-by-lipopolysaccharide-in-vitro
#4
Xianglin Meng, Dongsheng Fei, Mingming Liu, Songlin Yang, Ning Song, Lei Jiang, Kai Kang, Chuanchuan Nan, Yunpeng Luo, Shangha Pan, Mingyan Zhao
OBJECTIVE: The aim of this study was to observe the counter-effect of carbon monoxide-releasing molecule-2 (CORM-2) on lipopolysaccharide (LPS)-suppressed thrombomodulin (TM) and endothelial protein C receptor (EPCR) expressions from human umbilical vein endothelial cell (HUVEC), and to reveal its mechanisms. METHODS: HUVECs were divided into 5 treatment groups, wherein reagents were added simultaneously. TM and EPCR proteins of the cells and the culture medium levels of soluble TM, soluble EPCR, and matrix metalloproteinase-2 (MMP-2) were detected after administration, whereas mRNA levels of TM and EPCR, as well as nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) activity among groups, were also evaluated...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28538386/safety-and-efficiency-of-sglt2-inhibitor-combining-with-insulin-in-subjects-with-diabetes-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#5
Yingying Yang, Shi Chen, Hui Pan, Yun Zou, Bo Wang, Guixia Wang, Huijuan Zhu
BACKGROUND: We aimed to assess the safety and efficiency of the novel sodium glucose co-transporter 2 (SGLT2) inhibitor in combinations with insulin for type 1 and type 2 diabetes mellitus (T1DM and T2DM). METHODS: We searched Medline, Pubmed, Embase, and the Cochrane Collaboration Library from January 2010 to December 2016 without restriction of language. FDA data and Clinical Trials (http://www.clinicaltrials.gov) were also searched. Study selection, data extraction, and evaluation of risk of bias were performed by 2 persons independently...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28537878/biological-characterization-of-sn32976-a-selective-inhibitor-of-pi3k-and-mtor-with-preferential-activity-to-pi3k%C3%AE-in-comparison-to-established-pan-pi3k-inhibitors
#6
Gordon W Rewcastle, Sharada Kolekar, Christina M Buchanan, Swarna A Gamage, Anna C Giddens, Kit Y Tsang, Jackie D Kendall, Ripudaman Singh, Woo-Jeong Lee, Greg C Smith, Weiping Han, David J Matthews, William A Denny, Peter R Shepherd, Stephen M F Jamieson
Multiple therapeutic agents have been developed to target the phosphatidylinositol 3-kinase (PI3K) signaling pathway, which is frequently dysregulated in cancer promoting tumor growth and survival. These include pan PI3K inhibitors, which target class Ia PI3K isoforms and have largely shown limited single agent activity with narrow therapeutic windows in clinical trials. Here, we characterize SN32976, a novel pan PI3K inhibitor, for its biochemical potency against PI3K isoforms and mTOR, kinase selectivity, cellular activity, pharmacokinetics, pharmacodynamics and antitumor efficacy relative to five clinically-evaluated pan PI3K inhibitors: buparlisib, dactolisib, pictilisib, omipalisib and ZSTK474...
May 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28537781/blood-pressure-lowering-effects-of-alacalase-hydrolyzed-camellia-seed-hull-in-vitro-and-in-spontaneous-hypertensive-rats
#7
Ho-Jeong Lim, Mi-So Kim, Da-Som Kim, Young Jun Kim, Jin Hyup Lee, Jeong Hoon Pan, Eui-Cheol Shin, Jae Kyeom Kim
High blood pressure is one of the major risk factors for various diseases and angiotensin-converting enzyme (ACE) plays a critical role in blood pressure regulation. In our study, the responsive surface methodology was adopted to establish optimal Alcalase-hydrolysis conditions of camellia seed hull against ACE activity. The optimum conditions are hydrolysis temperature of 50.98°C, enzyme/substrate ratio of 2.85%, and hydrolysis pH of 7.12. In an animal feeding study, spontaneously hypertensive rats were treated with either a low or high dose of hydrolyzed Camellia japonica seed cake over 5 weeks...
May 24, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28537226/toward-hybrid-au-nanorods-m-au-ag-pd-and-pt-core-shell-heterostructures-for-ultrasensitive-sers-probes
#8
Xiaobin Xie, Guanhui Gao, Shendong Kang, Yanhua Lei, Zhengyin Pan, Tamaki Shibayama, Lintao Cai
Being able to precisely control the morphologies of noble metallic nanostructures is of essential significance for promoting the surface-enhanced Raman scattering (SERS) effect. Herein, we demonstrate an overgrowth strategy for synthesizing Au @ M (M = Au, Ag, Pd, Pt) core-shell heterogeneous nanocrystals with an orientated structural evolution and highly improved properties by using Au nanorods as seeds. With the same reaction condition system applied, we obtain four well-designed heterostructures with diverse shapes, including Au concave nanocuboids (Au CNs), Au @ Ag crystalizing face central cube nanopeanuts, Au @ Pd porous nanocuboids and Au @ Pt nanotrepangs...
May 24, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28535660/-clinical-investigation-on-ct-guided-cryoablation-for-treating-invasive-chest-wall-or-pleural-tumors
#9
M Wang, Y W Pan, Z G Zhou, Y Cui, K P Du, S Li
Objective: To evaluate the feasibility and short-term effect of CT guided cryoablation for malignant chest wall or pleural involvement. Methods: To follow up 22 patients with chest wall or pleural involvement of various malignancies who underwent cryoablation from January 2012 to January 2015 by conducting postoperative 1-, 3- and 6-month enhanced CT, MRI or PET-CT examinations, respectively, evaluate local curative effect, and observe their progression-free survival (PFS), postoperative pain remission and complications after the cryoablation...
May 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28535560/nomogram-for-predicting-intradiscal-cement-leakage-following-percutaneous-vertebroplasty-in-patients-with-osteoporotic-related-vertebral-compression-fractures
#10
Bin-Yan Zhong, Shi-Cheng He, Hai-Dong Zhu, Tao Pan, Wen Fang, Li Chen, Jin-He Guo, Gang Deng, Guang-Yu Zhu, Gao-Jun Teng
BACKGROUND: Intradiscal cement leakage (ICL) is a common complication following percutaneous vertebroplasty (PVP). However, the risk factors for such a complication are under debate and there is no accurate predictive nomogram to predict ICL. OBJECTIVES: To establish an effective and novel nomogram for ICL following PVP in patients with osteoporotic-related vertebral compression fractures (OVCFs). STUDY DESIGN: This was a retrospective study approved by the Institutional Review Board of our institution...
May 2017: Pain Physician
https://www.readbyqxmd.com/read/28535351/inherent-simple-cubic-lattice-being-responsible-for-ultrafast-solid-phase-change-of-ge2sb2te5
#11
Wen-Xiong Song, Zhi-Pan Liu, Limin Liu
Crystallization of solid is generally slow in kinetics for atom trapped in solid. Phase-change materials (PCMs) challenge current theory on its ultrafast reversible amorphous-to-crystal transition. Here by using stochastic surface walking global optimization method, we establish the first global potential energy surface (PES) for Ge2Sb2Te5. By analyzing all structures on global PES, we show that an inherent structural pattern of simple cubic lattice is present universally in low energy structures, either globally in a newly found metastable simple cubic crystal phase or locally in the amorphous structures...
May 23, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28535274/development-of-carbapenem-resistance-in-pseudomonas-aeruginosa-is-associated-with-oprd-polymorphisms-particularly-the-amino-acid-substitution-at-codon-170
#12
Jwu-Ching Shu, An-Jing Kuo, Lin-Hui Su, Tsui-Ping Liu, Ming-Hsun Lee, I-Ning Su, Tsu-Lan Wu
Objectives: Pan-susceptible Pseudomonas aeruginosa (PSPA) clinical isolates carrying an OprD with loop 7 shortening (the group-1A allele) were found to rapidly develop carbapenem resistance under continuous selection pressure. We further studied whether OprD polymorphisms are associated with the potential to develop carbapenem resistance. Methods: OprD amino acid sequences of 126 PSPA clinical isolates were analysed to determine their STs using P. aeruginosa strain PAO1 as the control strain...
May 23, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28535164/meat-dietary-heme-iron-and-risk-of-type-2-diabetes-the-singapore-chinese-health-study
#13
Mohammad Talaei, Ye-Li Wang, Jian-Min Yuan, An Pan, Woon-Puay Koh
We evaluated the relations of red meat, poultry, fish and shellfish, as well as heme iron intake, with risk of type 2 diabetes (T2D).The Singapore Chinese Health Study is a population-based cohort that recruited 63,257 Chinese adults aged 45-74 years from 1993 to 1998. Usual diet was evaluated by a validated 165-item semi-quantitative food-frequency questionnaire at recruitment. Physician-diagnosed T2D was self-reported during two follow-up interviews in 1999-2004 and 2006-2010. During a mean follow-up of 10...
May 23, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28535045/bet-bromodomain-inhibitors-with-one-step-synthesis-discovered-from-virtual-screen
#14
Alex M Ayoub, Laura M L Hawk, Ryan J Herzig, Jiewei Jiang, Andrea J Wisniewski, Clifford T Gee, Peiliang Zhao, Jin-Yi Zhu, Norbert Berndt, Nana K Offei-Addo, Thomas G Scott, Jun Qi, James E Bradner, Timothy R Ward, Ernst Schönbrunn, Gunda I Georg, William C K Pomerantz
Chemical inhibition of epigenetic regulatory proteins BrdT and Brd4 is emerging as a promising therapeutic strategy in contraception, cancer, and heart disease. We report an easily synthesized dihydropyridopyrmidine pan-BET inhibitor scaffold, which was uncovered via a virtual screen followed by testing in a fluorescence anisotropy assay. Dihydropyridpyimidine 3 was subjected to further characterization and is highly selective for the BET family of bromodomains. Structure-activity relationship data and ligand deconstruction highlight the importance of the substitution of the uracil moiety for potency and selectivity...
May 23, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28534995/low%C3%A2-level-mechanical-vibration-enhances-osteoblastogenesis-via-a-canonical-wnt-signaling%C3%A2-associated-mechanism
#15
Heqi Gao, Mingming Zhai, Pan Wang, Xuhui Zhang, Jing Cai, Xiaofei Chen, Guanghao Shen, Erping Luo, Da Jing
Osteoporosis is a skeletal metabolic disease characterized by reduced bone mass and a high susceptibility to fractures, in which osteoblasts and osteoclasts are highly involved in the abnormal bone remodeling processes. Recently, low‑magnitude, high‑frequency whole‑body vibration has been demonstrated to significantly reduce osteopenia experimentally and clinically. However, the underlying mechanism regarding how osteoblastic activity is altered when bone tissues adapt to mechanical vibration remains elusive...
May 19, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28534961/disruption-of-serine-threonine-protein-phosphatase-5-inhibits-tumorigenesis-of-urinary-bladder-cancer-cells
#16
Ming Chen, Jian-Min Lv, Jian-Qing Ye, Xin-Gang Cui, Fa-Jun Qu, Lu Chen, Xi Liu, Xiu-Wu Pan, Lin Li, Hai Huang, Qi-Wei Yang, Jie Chen, Lin-Hui Wang, Yi Gao, Dan-Feng Xu
Serine/threonine protein phosphatase 5 (PPP5C) is a member of the protein serine/threonine phosphatase family and has been shown to participate in multiple signaling cascades and tumor progression. We found that PPP5C was highly expressed in bladder cancer tissues compared to normal urothelial tissues, and positively correlated to tumor stages through ONCOMINE microarray data mining. Knockdown of PPP5C via a lentivirus-mediated short hairpin RNA (shRNA) markedly inhibited cell proliferation and colony formation...
May 16, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28534829/variation-in-the-genetic-repertoire-of-viruses-infecting-micromonas-pusilla-reflects-horizontal-gene-transfer-and-links-to-their-environmental-distribution
#17
Jan F Finke, Danielle M Winget, Amy M Chan, Curtis A Suttle
Prasinophytes, a group of eukaryotic phytoplankton, has a global distribution and is infected by large double-stranded DNA viruses (prasinoviruses) in the family Phycodnaviridae. This study examines the genetic repertoire, phylogeny, and environmental distribution of phycodnaviruses infecting Micromonas pusilla, other prasinophytes and chlorophytes. Based on comparisons among the genomes of viruses infecting M. pusilla and other phycodnaviruses, as well as the genome from a host isolate of M. pusilla, viruses infecting M...
May 19, 2017: Viruses
https://www.readbyqxmd.com/read/28534724/maternal-protein-restriction-depresses-the-duodenal-expression-of-iron-transporters-and-serum-iron-level-in-male-weaning-piglets
#18
Wenqiang Ma, Jingyu Lu, Shuxia Jiang, Demin Cai, Shifeng Pan, Yimin Jia, Ruqian Zhao
To investigate the effects of maternal dietary protein restriction on offspring Fe metabolism, twenty-four second-parity Landrace×Yorkshire sows were randomly allocated to standard-protein (SP) and low-protein (LP) groups. The SP sows were fed diets containing 15 and 18 % crude protein throughout pregnancy and lactation, respectively, whereas the LP sows were subjected to 50 % dietary protein restriction. Offspring birth weight was not affected, but the body weight at weaning (P=0·06) and average daily gain (P=0·01) of the female piglets were significantly decreased...
April 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28534626/correction-to-sequence-of-silicon-monolayer-structures-grown-on-a-ru-surface-from-a-herringbone-structure-to-silicene
#19
Li Huang, Yan-Fang Zhang, Yu-Yang Zhang, Wenyan Xu, Yande Que, En Li, Jin-Bo Pan, Ye-Liang Wang, Yunqi Liu, Shi-Xuan Du, Sokrates T Pantelides, Hong-Jun Gao
No abstract text is available yet for this article.
May 23, 2017: Nano Letters
https://www.readbyqxmd.com/read/28534617/comparative-proteomics-reveals-timely-transport-into-cilia-of-regulators-or-effectors-as-a-mechanism-underlying-ciliary-disassembly
#20
Limei Wang, Lixiao Gu, Dan Meng, Qiong Wu, Haiteng Deng, Junmin Pan
Primary cilia are assembled and disassembled during cell cycle progression. During ciliary disassembly, ciliary axonemal microtubules (MTs) are depolymerized accompanied with extensive posttranslational protein modifications of ciliary proteins including protein phosphorylation, methylation and ubiquitination. These events are hypothesized to involve transport of effectors or regulators into cilia at the time of ciliary disassembly from the cell body. To prove this hypothesis and identify new proteins involved in ciliary disassembly, we analyzed disassembling flagella in Chlamydomonas using comparative proteomics with TMT labeling...
May 23, 2017: Journal of Proteome Research
keyword
keyword
45048
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"