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https://www.readbyqxmd.com/read/29458034/fluorescence-linked-immunosorbent-assay-for-detection-of-phenanthrene-and-its-homolog
#1
Yu Sun, Yansong Li, Xingyu Meng, Bin Qiao, Pan Hu, Xianmei Meng, Shiying Lu, Honglin Ren, Zengshan Liu, Yu Zhou
A competitive fluorescence-linked immunosorbent assay (FLISA) was developed using rhodamine B isothiocyanate (RBITC) as the model fluorescent dye conjugate monoclonal antibody (McAb) for detection of Phe and its homolog (acenaphthene, fluorene, fluoranthene, pyrene and indeno [1,2,3-cd] pyrene) in water samples. The detection range of the assay for Phe was from 2.10 to 91.95 ng/mL. The limit of detection was 1.05 ng/mL, which was approximately 2-fold lower than that of traditional ic-ELISA. Compared with traditional ic-ELISA, more than 70 min was saved because of only one immunoreaction step was needed to accomplish the assay...
February 16, 2018: Analytical Biochemistry
https://www.readbyqxmd.com/read/29457720/anion-and-solvent-induced-single-crystal-to-single-crystal-transformation-within-an-iron-ii-triazole-system-a-promising-luminescent-probe-for-cro-4-2-and-cyano-containing-molecules
#2
Ying Wang, Ran Chen, Wei Jia, Qian Wang, Chong-Yu Xue, Jia-Hui Fan, Wan-Ru Qi, Yue-Juan Qin, Yu-Hua Pan, Rong-Rong Yang
Anion- and solvent-induced single-crystal-to-single-crystal transformation within an iron(II) triazole system has been generated from {[Fe(TPPT)2 Cl2 ]·CHCl3 }n (1a) to [Fe(TPPT)(C2 O4 )0.5 Cl(H2 O)]n (1b). Luminescence studies indicated that the resultant 1b can be considered as a promising luminescent probe for CrO4 2- and cyano molecules.
February 19, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29457648/reduction-of-infection-risk-meditated-by-co-culturing-vibrio-parahaemolyticus-and-listeria-monocytogenes-in-refrigerated-cooked-shrimp
#3
Ben Niu, Lili Mu, Lili Xiao, Zhaohuan Zhang, Pradeep K Malakar, Haiquan Liu, Yingjie Pan, Yong Zhao
BACKGRROUD: Vibrio parahaemolyticus and Listeria monocytogenes are seafood pathogens of public health significance and predictive models are effective tools for quantitative microbial risk assessment (QMRA) of these pathogens. However, most current predictive models are based on growth of single strains in broth cultures and interactions of two or more bacteria in a food matrix can skew the outcomes of the predictions. Therefore, the impact of V. parahaemolyticus and L. monocytogenes when co-cultured and in mono culture on cooked shrimp at cold storage was investigated in this study...
February 19, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29457639/hepatitis-e-virus-infection-in-hiv-infected-patients-a-large-cohort-study-in-yunnan-province-china
#4
Shiyi Zhou, Li Ren, Xueshan Xia, Zhijiang Miao, Fen Huang, Yunlong Li, Mei Zhu, Zhenrong Xie, Yu Xu, Yuan Qian, Qiuwei Pan, Kunhua Wang
BACKGROUND & AIMS: Hepatitis E virus (HEV) infection in immunocompromised patients often results in distinct outcome, compared to the infection in general population. This study aimed to investigate the prevalence, potential risk factors and clinical features of HEV infection among HIV patients treated with antiretroviral therapy (ART) in Yunnan province, China. METHODS: A total of 770 HIV-infected patients between May 2015 and February 2016 were enrolled in Yunnan, China...
February 19, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29457540/therapeutic-efficacy-of-cd34-cell-involved-mononuclear-cell-therapy-for-no-option-critical-limb-ischemia-a-meta-analysis-of-randomized-controlled-clinical-trials
#5
Tianyue Pan, Zheng Wei, Yuan Fang, Zhihui Dong, Weiguo Fu
Early-phase clinical trials in patients with critical limb ischemia (CLI) have shown positive results of mononuclear cell therapy. The current meta-analysis investigated whether cluster of differentiation (CD) 34+ mononuclear cell therapy (CD34+ MCT) is effective for no-option CLI. Ten randomized controlled clinical studies of CD34+ MCT for no-option CLI with 479 patients were identified and analyzed for pooled results. Compared to control groups, the CD34+ MCT was associated with lower total amputation (odds ratio (OR): 0...
February 1, 2018: Vascular Medicine
https://www.readbyqxmd.com/read/29457486/case-report-of-empagliflozin-induced-cutaneous-polyarteritis-nodosa
#6
Derek To, Scott Bradshaw, Jennifer Lipson
Polyarteritis nodosa (PAN) is a rare vasculitis affecting medium-sized vessels. Cutaneous PAN is a clinical variant, and we report the first case of empagliflozin-induced cutaneous PAN in a 69-year-old man. After starting empagliflozin, the patient presented with tender subcutaneous nodules on his legs, which showed a medium-sized vessel vasculitis on histopathology. Upon cessation of this medication, he had full resolution of these nodules. This case illustrates that empagliflozin can induce cutaneous PAN, and further attention to this medication's association with cutaneous PAN is warranted...
February 1, 2018: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29457451/boosted-electrochemical-immunosensing-gm-crops-markers-using-nanobody-and-mesoporous-carbon
#7
Mingming Zhang, Guanghui Li, Qing Zhou, Deng Pan, Min Zhu, Runyu Xiao, Yuanjian Zhang, Guoqiu Wu, Yakun Wan, Yanfei Shen
The problems of environmental security and the potential risks of human health caused by transgenic crops have aroused numerous attention. Recent studies reveal 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) from Agrobacterium sp. strain CP4 protein (CP4-EPSPS), which shows very high resistance to herbicide glyphosate, is a typical biomarker of genetically modified (GM) crops. For this reason, it is highly anticipated to devise a sensitive and convenient strategy to detect CP4-EPSPS protein in crops. Herein, we reported a simple electrochemical immunosensor by coupling nanobody, ordered mesoporous carbon (OMC), and thionine (Th)...
February 19, 2018: ACS Sensors
https://www.readbyqxmd.com/read/29457444/-effect-of-surface-modification-on-biotribological-properties-of-ultra-high-molecular-weight-polyethylene-artificial-joints
#8
REVIEW
Jie Ding, Yu-Song Pan
Friction and wear of ultra-high molecular weight polyethylene is a major cause of artificial joint failure. According to mechanism of surface modification method, friction reduction and wear-resistance properties of UHMWPE were improve by several kinds of surface modification methods. Meanwhile, this do not damage the internal structure and properties of UHMWPE. In the process, condition is easy to control and operation is simple. However, reaction time of radiation crosslinking method is too long, the material will be oxidized embrittlement; Monomer itself homopolymerization are seriously in the process of surface grafting; The injection layer of ion implantation methods is very thin and easy to be destroyed...
December 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29457420/-treatment-of-intercondylar-fracture-of-the-humerus-through-internal-and-external-elbow-approach-or-elbow-posterior-olecranon-osteotomy-approach
#9
Yun-Xiang Zhong, Xiong-Hui Zhang, Guo-Xiong Cai, Hong-Zhi Zhou, Wen-Li Yang, Xi-Bin Pan, Long-Zhou Guan, Huo-Ling Zhang
OBJECTIVE: To investigate the efficacy, advantages and disadvantages of internal and external elbow joint approach and olecranon osteotomy approach for the treatment of intercondylar fracture of humerus. METHODS: From October 2012 to May 2016, 18 cases of intercondylar fracture of humerus were treated by operation including 12 males and 6 females with a mean age of 33.5 years old (ranged from 4 to 56 years old); 8 cases were operated by internal and external elbow joint approach, 10 cases were operated by olecranon osteotomy approach...
October 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29457398/-clinical-outcome-analysis-on-using-extensor-digitorum-communis-splitting-approach-for-the-treatment-of-radial-head-fractures
#10
Guan-Yi Liu, Ling-Yong Jing, Zhi-Jun Pan, Long-Jun Chen, Ming Li, Jian-Xiang Feng, Wei-Hu Ma
OBJECTIVE: To explore the clinical outcomes of internal fixation or replacement for the treatment of radial head fractures through the extensor digitorum communis splitting approach. METHODS: From July 2012 to May 2015, 25 patients with radial head fractures were reviewed. There were 17 males and 8 females, ranging in age from 20 to 67 years old, with a mean age of 39 years old. Twenty-one patients were treated with reconstruction of plate internal fixation, and 4 patients were treated with radial head replacement...
November 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29457136/unexpected-evolutionary-benefit-to-phages-imparted-by-bacterial-crispr-cas9
#11
Pan Tao, Xiaorong Wu, Venigalla Rao
Bacteria and bacteriophages arm themselves with various defensive and counterdefensive mechanisms to protect their own genome and degrade the other's. CRISPR (clustered regularly interspaced short palindromic repeat)-Cas (CRISPR-associated) is an adaptive bacterial defense mechanism that recognizes short stretches of invading phage genome and destroys it by nuclease attack. Unexpectedly, we discovered that the CRISPR-Cas system might also accelerate phage evolution. When Escherichia coli bacteria containing CRISPR-Cas9 were infected with phage T4, its cytosine hydroxymethylated and glucosylated genome was cleaved poorly by Cas9 nuclease, but the continuing CRISPR-Cas9 pressure led to rapid evolution of mutants that accumulated even by the time a single plaque was formed...
February 2018: Science Advances
https://www.readbyqxmd.com/read/29456851/duodenal-mucinous-adenocarcinoma-presenting-as-ileus-obstructive-jaundice-and-massive-ascites-a-case-report
#12
Dongbing Ding, Yao Yao, Songbai Zhang
Duodenal mucinous adenocarcinoma (DMA) is a malignancy with a rather low morbidity. However, its incidence in China has not been clearly determined. We herein report a case of a 70-year-old female patient who presented with ileus, obstructive jaundice and massive ascites simultaneously. Gastroendoscopy revealed copious amounts of colloidal mucin in the gastric cavity. The neoplasm was not visualized on computed tomography or magnetic resonance imaging, and an exploratory laparotomy was performed to investigate the abdomen...
March 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29456736/-brucea-javanica-seed-oil-enhances-the-radiosensitivity-of-esophageal-cancer-by-inhibiting-hypoxia-inducible-factor-1%C3%AE-in-vitro-and-in-vivo
#13
Peng Pan, Bai-Xia Yang, Xiao-Lin Ge
Brucea javanica oil emulsion (BJOE) has been used clinically to treat esophageal cancer combined with radiotherapy for numerous years in China. However, the detailed mechanism remains unclear. Thus, the effects of BJOE on the radiosensitivity of esophageal squamous cell carcinoma (ESCC) were evaluated in vitro and in vivo . The growth inhibitory effects of different BJOE concentrations were determined through an MTT assay. Radiosensitivity was evaluated through focal formation measurements and clone formation assays...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29456703/silencing-of-tgif-sensitizes-mda-mb-231-human-breast-cancer-cells-to-cisplatin-induced-apoptosis
#14
Teng Pan, Tingting Mao, Haiyan Yang, Haiyu Wang, Yadong Wang
The present study was designed to explore the sensitivity of MDA-MB-231 cells to cisplatin after silencing the expression of TG-interacting factor (TGIF) protein. Cell viability was measured using an MTT assay. Cell apoptosis was detected by the annexin V and dead cell assay and the Hoechst staining assay. Protein expression was analyzed using western blot analysis. A colony formation assay was also performed. It was observed that cisplatin reduced the expression of TGIF protein in a dose- and time-dependent manner...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29456674/inflammation-responses-in-patients-with-pulmonary-tuberculosis-in-an-intensive-care-unit
#15
Qiu-Yue Liu, Fen Han, Li-Ping Pan, Hong-Yan Jia, Qi Li, Zong-De Zhang
Pulmonary tuberculosis caused by Mycobacterium tuberculosis remains a global problem. Inflammatory responses are the primary characteristics of patients with pulmonary tuberculosis in intensive care units (ICU). The aim of the present study was to investigate the clinical importance of inflammatory cells and factors for patients with pulmonary tuberculosis in ICU. A total of 124 patients with pulmonary tuberculosis in ICU were recruited for the present study. The inflammatory responses in patients with pulmonary tuberculosis in ICU were examined by changes in inflammatory cells and factors in the serum...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29456622/does-the-oncology-community-have-a-rejection-bias-when-it-comes-to-repurposed-drugs
#16
EDITORIAL
Bishal Gyawali, Pan Pantziarka, Sergio Crispino, Gauthier Bouche
Among the various measures proposed to combat the challenge of financial toxicity in cancer care, an important strategy is the use of lower-priced drugs instead of expensive alternatives. However, the oncology community seems to either ignore or more readily reject cheaper drugs in cancer care compared to more expensive alternatives. In this commentary, we present three examples of lower-priced drugs rejected or ignored by the oncology community and contrast this with three expensive drugs where persistent optimism remained despite negative clinical trial results...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29456567/influence-of-blood-glucose-level-on-the-prognosis-of-patients-with-diabetes-mellitus-complicated-with-ischemic-stroke
#17
REVIEW
Xiao-Liu Dong, Fei Guan, Shi-Jun Xu, Li-Xia Zhu, Pan-Pan Zhang, Ai-Bin Cheng, Tie-Jun Liu
We carried out this meta-analysis for the aim of exploring the influence of diabetes mellitus (DM) on the prognosis of patients with ischemic stroke. Relevant studies were identified using computerized databases supplemented with manual search strategies. The included studies were strictly followed the inclusion and exclusion criteria. Case-control studies which related to the influence of DM on the prognosis of patients with ischemic stroke were selected. Statistical analyses were implemented with the STATA version 12...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/29456182/mitochondrial-dysfunctions-contribute-to-hypertrophic-cardiomyopathy-in-patient-ipsc-derived-cardiomyocytes-with-mt-rnr2-mutation
#18
Shishi Li, Huaye Pan, Chao Tan, Yaping Sun, Yanrui Song, Xuan Zhang, Wei Yang, Xuexiang Wang, Dan Li, Yu Dai, Qiang Ma, Chenming Xu, Xufen Zhu, Lijun Kang, Yong Fu, Xuejun Xu, Jing Shu, Naiming Zhou, Feng Han, Dajiang Qin, Wendong Huang, Zhong Liu, Qingfeng Yan
Hypertrophic cardiomyopathy (HCM) is the most common cause of sudden cardiac death in young individuals. A potential role of mtDNA mutations in HCM is known. However, the underlying molecular mechanisms linking mtDNA mutations to HCM remain poorly understood due to lack of cell and animal models. Here, we generated induced pluripotent stem cell-derived cardiomyocytes (HCM-iPSC-CMs) from human patients in a maternally inherited HCM family who carry the m.2336T>C mutation in the mitochondrial 16S rRNA gene (MT-RNR2)...
February 13, 2018: Stem Cell Reports
https://www.readbyqxmd.com/read/29455482/-clinical-efficacy-of-unilateral-percutaneous-transfacet-screws-combined-with-contralateral-pedicle-screw-versus-bilateral-pedicle-screws-fixation-in-the-treatment-of-the-degenerative-lumbar-disease
#19
Rong-Xue Hao, Hui Zhou, Hao Pan, Jun Yue, Hui-Guo Chen, He-Jie Yang, Gao-Yong Jia, Dong Wang, Yan Lin, Hua-Zi Xu
OBJECTIVE: To investigate the surgical outcome of unilateral pedicle screw(UPS) after TLIF technique combined with contralateral percutaneous transfacet screw(PTS) fixation vs bilateral pedicle screws(BPS) fixation in treatment of degenerative lumbar disease. METHODS: From January 2009 to June 2012, 46 patients with degenerative lumbar diseases, including 30 males and 16 females with an average age of 51.5 years old, who were divided into two groups according to different fixation methods...
September 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29455429/predictive-performance-of-physiologically-based-pharmacokinetic-models-in-predicting-drug-drug-interactions-involving-enzyme-modulation
#20
Chia-Hsiang Hsueh, Vicky Hsu, Yuzhuo Pan, Ping Zhao
BACKGROUND: Physiologically-based pharmacokinetic (PBPK) modeling in predicting metabolic drug-drug interactions (mDDIs) is routinely used in drug development. Currently, the US FDA endorses the use of PBPK to potentially support dosing recommendations for investigational drugs as enzyme substrates of mDDIs, and to inform a lack of mDDIs for investigational drugs as enzyme modulators. METHODS: We systematically evaluated the performance of PBPK modeling in predicting mDDIs published in the literature...
February 17, 2018: Clinical Pharmacokinetics
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