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P Zeng, X P Lyu, H Guo, H R Cheng, F Jiang, W Z Pan, Z W Wang, S W Liang, Y Q Hu
In August 2016, continuous measurements of volatile organic compounds (VOCs) and trace gases were conducted at an urban site in Wuhan. Four high-ozone (O3 ) days and twenty-seven non-high-O3 days were identified according to the China's National Standard Level II (∼100 ppbv). The occurrence of high-O3 days was accompanied by tropical cyclones. Much higher concentrations of VOCs and carbon monoxide (CO) were observed on the high-O3 days (p < 0.01). Model simulations revealed that vehicle exhausts were the dominant sources of VOCs, contributing 45...
June 15, 2018: Environmental Pollution
Wen-Peng Zhao, Hong-Wei Wang, Jing Liu, Pan-Pan Tan, Lin Lin, Bian-Hua Zhou
Excessive fluoride (F) intake decreases the development of potential oocytes by inducing oxidative stress and apoptosis in female mice in our previous study. This study aims to investigate the underlying mechanisms of F-induced follicular developmental dysplasia. Pathomorphological changes in the ovary tissues were observed under light and transmission electron microscopes. DNA damage and proliferation in granulosa cells were analysed by TUNEL staining and BrdU measurement. The protein expression of cell proliferation related regulatory factors including JNK, STAT3, STAT5, CDK2, CDK4, PCNA and Ki67 in the ovary tissues was measured by immunohistochemistry and Western blot analyses...
June 12, 2018: Chemosphere
Catherine T Frenette, Giuseppe Morelli, Mitchell L Shiffman, R Todd Frederick, Raymond A Rubin, Michael B Fallon, Jason T Cheng, Matt Cave, Saira A Khaderi, Omar Massoud, Nikolaos Pyrsopoulos, James S Park, James M Robinson, Mason Yamashita, Alfred P Spada, Jean L Chan, David T Hagerty
BACKGROUND & AIMS: Caspase-mediated apoptosis and inflammation contribute to progression of liver disease. Emricasan is a pan-caspase inhibitor that reduced serum markers of apoptosis and liver inflammation in patients with hepatitis C and non-alcoholic steatohepatitis (NASH). METHODS: We performed a multicenter study of 86 patients with cirrhosis (Child-Pugh class A or B; mean score, 6.9; 38% with alcohol-associated cirrhosis, 29% with HCV-associated cirrhosis, and 23% with NASH) and model for end-stage liver disease (MELD) scores of 11-18 (mean, 12...
June 15, 2018: Clinical Gastroenterology and Hepatology
Gaoxing Mei, Qi Yuan, Guoqing Liu, Yun Pan, Min Bao
Adaptation to changes of the environment is an essential function of the visual system. Recent studies have revealed that prolonged viewing of a point-light display of a human walker can produce the perception of a point-light walker facing in the opposite direction in a subsequent ambiguous test. Similar effects of biological motion adaptation have been documented for various properties of the point-light walkers. However, the time course and controlling mechanisms for biological motion adaptation have not yet been examined...
June 15, 2018: Vision Research
Young C Shin, Georg F Bischof, William A Lauer, Lucas Gonzalez-Nieto, Eva G Rakasz, Gregory M Hendricks, David I Watkins, Mauricio A Martins, Ronald C Desrosiers
The properties of the human immunodeficiency virus (HIV) pose serious difficulties for the development of an effective prophylactic vaccine. Here we describe the construction and characterization of recombinant (r), replication-competent forms of rhesus monkey rhadinovirus (RRV), a gamma-2 herpesvirus, containing a near-full-length (nfl) genome of the simian immunodeficiency virus (SIV). A 306-nucleotide deletion in the pol gene rendered this nfl genome replication-incompetent as a consequence of deletion of the active site of the essential reverse transcriptase enzyme...
June 18, 2018: PLoS Pathogens
Hui Jia, Malcolm Koo, Yu-Hsi Hsieh, Chih-Wei Tseng, Chi-Tan Hu, Linhui Zhang, Tao Dong, Yanglin Pan, Felix W Leung
GOALS: To assess the factors associated with adenoma detection in propofol-sedated patients. BACKGROUNDS: Low adenoma detection rate (ADR) are linked to increased risk of interval cancer and related deaths. Compared with air insufflation (AI) colonoscopy, the method of water exchange (WE) significantly decreased insertion pain and increased ADR in unsedated patients. Deep sedation with propofol has been increasingly used in colonoscopy. One report suggested that WE significantly increased ADR in propofol-sedated patients, but the factors associated with adenoma detection were not analyzed...
June 15, 2018: Journal of Clinical Gastroenterology
Calvin Q Pan, Benjamin C Tiongson, Ke-Qin Hu, Steven-Huy B Han, Myron Tong, Danny Chu, James Park, Tai Ping Lee, Kalyan Ram Bhamidimarri, Xiaoli Ma, Pei Ying Xiao, Smruti R Mohanty, Dan Wang
BACKGROUND: Limited data exist with regard to treatment outcomes in Asian Americans with chronic hepatitis C (CHC). We evaluated sofosbuvir (SOF)-based regimens in a national cohort of Asian Americans. METHODS: Eligible Asian Americans patients with CHC who had posttreatment follow-up of 24 weeks for SOF -based therapies from December 2013 to June 2017 were enrolled from 11 sites across the United States. The primary endpoint was sustained virologic response (SVR) rates at posttreatment weeks 12 and 24...
June 16, 2018: Journal of Clinical Gastroenterology
Chuan-Chuan Wei, Zhi Luo, Christer Hogstrand, Yi-Huan Xu, Li-Xiang Wu, Guang-Hui Chen, Ya-Xiong Pan, Yu-Feng Song
Zinc (Zn) deficiency is the most consistently discovered nutritional manifestations of fatty liver disease. Although Zn is known to stimulate hepatic lipid oxidation, little is known about its underlying mechanism of action in lipolysis. Given the potential role of lipophagy in lipid metabolism, the purpose of this study was to test the hypothesis that Zn attenuates hepatic lipid accumulation by modulating lipophagy. The present study indicated that Zn is a potent promoter of lipophagy. Zn administration significantly alleviated hepatocellular lipid accumulation and increased the release of free fatty acids in association with enhanced fatty acid oxidation and inhibited lipogenesis, which was accompanied by activation of autophagy...
June 18, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Peeradone Srichan, Saranath Lawpoolsri Niyom, Oranut Pacheun, Sopon Iamsirithawon, Supawat Chatchen, Caroline Jones, Lisa J White, Wirichada Pan-Ngum
Background: This study focused on evaluating the fumigation scheme and identifying problems encountered during the operation in the Bangkok Metropolitan Administration area. Methods: Ten district health officers working in different fumigation teams of the dengue outbreak control programme around Bangkok had participated in an in-depth interview. Five predetermined themes, including (i) dengue surveillance and control strategy, (ii) quality and availability of equipment, (iii) delays, (iv) human resources, and (v) area coverage, and other emerging themes were addressed during the interviews...
June 15, 2018: International Health
Wei Chen, Nora D Volkow, James Li, Yingtian Pan, Congwu Du
Low-frequency oscillations (LFOs) in hemodynamics assessed by fMRI reflect synchronized neuronal activities and are the basis for mapping brain function and its disruption by drugs and disease. Here we assess if cocaine disrupts coupling between neuronal and vascular LFOs by simultaneously measuring cortical field potentials (FP) and cerebral blood flow (CBF) regarding their LFOs (0-1 Hz) spectral bandwidths in the somatosensory cortex of naïve and chronic cocaine-exposed rats at baseline and during cocaine intoxication...
April 18, 2018: Cerebral Cortex
Liu-Zhu Pan, Shuai Zhu, Min Zhang, Ming-Jiu Sun, Juan Lin, Fei Chen, Jing-He Tan
Reported classifications of germinal vesicle (GV) chromatin configurations in pig oocytes were not done by uniform standards and they were not well correlated with oocyte competence. In this study, GV-chromatin of pig oocytes was classified into non-surrounded nucleolus (NSN), surrounded nucleolus (SN), partly NSN (pNSN) and SN (pSN), prematurely-condensed NSN (cNSN), pNSN (cpNSN) and pSN (cpSN), and early diakinesis (ED) patterns. During in vitro maturation in 199-medium, NSN oocytes from 1-2 mm follicles went consecutively through pNSN, pSN, cpSN and ED before undergoing GV breakdown, and chromatin in some SN oocytes from 3-6 mm follicles re-decondensed into a RDC configuration...
June 14, 2018: Biology of Reproduction
Lars Peters, Kamilla Laut, Chiara Resnati, Santos Del Campo, Clifford Leen, Karolin Falconer, Tatyana Trofimova, Dzmitry Paduta, Jose Gatell, Andri Rauch, Karine Lacombe, Pere Domingo, Nikoloz Chkhartishvili, Robert Zangerle, Raimonda Matulionyte, Viktar Mitsura, Thomas Benfield, Kai Zilmer, Irina Khromova, Jens Lundgren, Jürgen Rockstroh, Amanda Mocroft
BACKGROUND AND AIMS: To investigate the uptake of HCV therapy among HIV/HCV coinfected patients in the pan-European EuroSIDA study between 2011-2016. METHODS: All HCV-RNA+ patients were included. Baseline was defined as latest of anti-HCV+, January 2011 or enrolment in EuroSIDA. The incidence of starting first IFN-free direct-acting antiviral (DAA) therapy was calculated. Factors associated with starting IFN-free DAA were determined by Poisson regression. RESULTS: Among 4308 HCV-RNA+ patients (1255, 970, 663, 633, 787 from South, West, North, Central East and East Europe, respectively) with 11863 person years of follow up (PYFU), 1113 (25...
June 14, 2018: AIDS
Amie L Severino, Rong Chen, Kenichiro Hayashida, Carol A Aschenbrenner, Haiguo Sun, Christopher M Peters, Silvia Gutierrez, Bethany Pan, James C Eisenach
BACKGROUND: Recovery from pain after surgery is faster after cesarean delivery than after other abdominal procedures. The authors hypothesized that recovery in rats after surgery could be reversed by antagonism of spinal oxytocin or vasopressin receptors, that there may be a sex difference, and that spinal oxytocin innervation could change after surgery. METHODS: Male and female rats underwent partial spinal nerve ligation surgery. Effects of nonselective and selective oxytocin and vasopressin 1A receptor antagonists on mechanical hypersensitivity during partial recovery were assessed (n = 8 to 14/group)...
June 15, 2018: Anesthesiology
Shannon O'Connor, Vera Grywacheski, Krista Louie
The rise in opioid-related harms is an issue of increasing public health importance in Canada. This analysis used data from the Hospital Morbidity Database and the National Ambulatory Care Reporting System to determine the number of opioid poisoning hospitalizations and emergency department visits in Canada. Opioid poisoning hospitalizations have increased over the past 10 years, reaching 15.6 per 100 000 population in 2016/17. Emergency department visits due to opioid poisoning have also increased in Alberta and Ontario, the two provinces that collect emergency department data at the level of detail required for this analysis...
June 2018: Health Promotion and Chronic Disease Prevention in Canada
Bat-Sheva Gottesman, Pnina Shitrit, Michal Katzir, Michal Chowers
BACKGROUND: Increasing antibiotic resistance in the community results in greater use of empiric broad spectrum antibiotics for patients at hospital admission. As a measure of antibiotic stewardship it is important to identify a patient population that can receive narrow spectrum antibiotics. OBJECTIVES: To evaluate resistance patterns of Escherichia coli bloodstream infection (BSI) from strictly community-acquired infection and the impact of recent antibiotic use on this resistance...
June 2018: Israel Medical Association Journal: IMAJ
Hua Zeng, Yue Gu, Gaofeng Teng, Yimeng Liu, Jiaxin Zheng, Feng Pan
A recent discovery of anionic redox activity in Li-rich layered compounds opens a new direction for the design of high-capacity cathode materials for lithium-ion batteries. Here using extensive ab initio calculations, the thermodynamic existence of the Li-rich phase in LiFePO4 to form Li1+xFe1-xPO4 with x not exceeding 12.5% has been proved. Anionic redox activity and structural stability during delithiation are further investigated. Interestingly, it is found that Li1+xFe1-xPO4 cannot be delithiated completely and thus cannot achieve extra capacity by anionic redox activity, because the local oxygen-ion redox will cause the fracture of the rigid framework formed by phosphate tetrahedral polyanions...
June 18, 2018: Physical Chemistry Chemical Physics: PCCP
Biao Wang, Dingjun Hao, Zhen Zhang, Wenjie Gao, Hu Pan, Yuan Xiao, Baorong He, Lingbo Kong
Myricitrin is a natural occurring flavonoid glycoside that possesses effects on inhibiting nitric oxide (NO) transmission and preventing inflammatory reaction. Although previous study showed the myricitrin possesses antibone loss effects via reducing the expression of IL-6 and partially suppressing reactive oxygen species (ROS) production. However, the effects of myricitrin on nuclear factor-kappaB ligand (RANKL)-stimulated osteoclastogenesis have not yet been further investigated. The current study was aimed to demonstrating the inhibitory effects of myricitrin on RANKL-stimulated osteoclastogenesis and relevant mechanisms...
June 17, 2018: Journal of Cellular and Molecular Medicine
Sándor Katz, Viktória Zsiros, Nikolett Dóczi, Anna L Kiss
In our previous work, we showed that during inflammation-induced epithelial-to-mesenchymal transition (EMT), mesenteric mesothelial cells express ED1 (pan-macrophage marker), indicating that they are transformed into macrophage-like cells. In this paper, we provide additional evidences about this transition by following the phagocytic activity and the TNFα production of mesenteric mesothelial cells during inflammation. Upon injection of India ink particles or fluorescent-labeled bioparticles (pHrodo) into the peritoneal cavity of rats pretreated with Freund's adjuvant, we found that mesothelial cells efficiently engulfed these particles...
June 18, 2018: Inflammation
Jie Pan, Meimei Liu, Ting Chen, Yongxu Cheng, Xugan Wu
The published online version contains mistake in Title and in Acknowledgement section. Please find below for the needed corrections.
June 18, 2018: Cell and Tissue Research
Pengfei Hao, Ting Zhu, Qiong Su, Jiande Lin, Rong Cui, Xinxin Cao, Yaping Wang, Anqiang Pan
Single crystalline fork-like potassium vanadate (K2 V8 O21 ) has been successfully prepared by electrospinning method with a subsequent annealing process. The as-obtained K2 V8 O21 forks show a unique layer-by-layer stacked structure. When used as cathode materials for lithium-ion batteries, the as-prepared fork-like materials exhibit high specific discharge capacity and excellent cyclic stability. High specific discharge capacities of 200.2 and 131.5 mA h g-1 can be delivered at the current densities of 50 and 500 mA g-1 , respectively...
2018: Frontiers in Chemistry
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