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https://www.readbyqxmd.com/read/29232633/carbazole-alkaloids-from-clausena-hainanensis-with-their-potential-antiproliferative-activities
#1
Yan-Lei Ma, Yan-Ping Liu, Chao Zhang, Wan-Hui Zhao, Shi Shi, Dan-Nv He, Pan Zhang, Xiao-Hong Liu, Ting-Ting Han, Yan-Hui Fu
Five new carbazole alkaloids, clausehainanines A-E (1-5), together with seven known analogues (6-12) were isolated from the stems and leaves of C. hainanensis. Their structures were elucidated by extensive spectroscopic methods. Among them, compounds 1-5 were an unusual type of carbazole alkaloids, possessing diverse isopentenyl derivatives as substituents at C-2. All isolated compounds were evaluated for their antiproliferative activities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro...
December 5, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29232610/electrospun-polydimethylsiloxane-polyacrylonitrile-titanium-dioxide-nanofibers-as-a-new-coating-for-determination-of-alpha-linolenic-acid-in-milk-by-direct-immersion-solid-phase-nanoextraction
#2
Sahar Sadeghi, Afsaneh Mollahosseini
In this study, polydimethylsiloxane/polyacrylonitrile/titanium dioxide (PDMS/PAN/TiO2) nanofibers were synthesized via electrospinning method to extract and quantify alpha-linolenic acid (ALA, C18:3), as a model analyte, in milk by direct immersion-solid phase nanoextraction (DI-SPNE) with gas chromatography-flame ionization detector (GC-FID). The affecting factors on the electrospinning process such as, PDMS concentration, amount of TiO2 nanoparticles (NPs), voltage, and electrospinning distance were optimized using Taguchi's orthogonal design...
December 9, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29232553/synthetic-lethality-of-combined-bcl-2-inhibition-and-p53-activation-in-aml-mechanisms-and-superior-antileukemic-efficacy
#3
Rongqing Pan, Vivian Ruvolo, Hong Mu, Joel D Leverson, Gwen Nichols, John C Reed, Marina Konopleva, Michael Andreeff
Evasion of apoptosis is a hallmark of cancer. Bcl-2 and p53 represent two important nodes in apoptosis signaling pathways. We find that concomitant p53 activation and Bcl-2 inhibition overcome apoptosis resistance and markedly prolong survival in three mouse models of resistant acute myeloid leukemia (AML). Mechanistically, p53 activation negatively regulates the Ras/Raf/MEK/ERK pathway and activates GSK3 to modulate Mcl-1 phosphorylation and promote its degradation, thus overcoming AML resistance to Bcl-2 inhibition...
December 11, 2017: Cancer Cell
https://www.readbyqxmd.com/read/29232547/aml-therapy-wake-up-the-guardian-and-cut-loose-the-executioners
#4
Dario C Altieri
In this issue of Cancer Cell, Pan et al. show that a combination therapy designed to reactivate the p53 tumor suppressor while antagonizing the anti-apoptotic function of Bcl-2 is highly active in preclinical models of refractory acute myeloid leukemia (AML). The results may move the needle in this hard-to-treat malignancy.
December 11, 2017: Cancer Cell
https://www.readbyqxmd.com/read/29232335/endogenous-klebsiella-pneumoniae-endophthalmitis-in-northern-california
#5
Ryan A Shields, Stephen J Smith, Carolyn K Pan, Diana V Do
PURPOSE: To report the clinical features, treatment modalities, and visual outcomes in 12 eyes with endogenous Klebsiella pneumoniae endophthalmitis (EKPE). METHODS: The medical records of all patients diagnosed with EKPE at Stanford Hospital (Palo Alto, CA) and Santa Clara Valley County Hospital (Santa Clara, CA) from January 2000 to March 2017 were retrospectively reviewed. RESULTS: A total of 10 patients (12 eyes) were diagnosed with EKPE...
December 11, 2017: Retina
https://www.readbyqxmd.com/read/29232309/a-bispecific-antibody-based-on-pertuzumab-fab-has-potent-antitumor-activity
#6
Wentong Deng, Jiayu Liu, Haitao Pan, Li Li, Changhua Zhou, Xiaojuan Wang, Rui Shu, Bin Dong, Donglin Cao, Qing Li, Zhong Wang
Human epidermal growth factor receptor 2 (HER2) is frequently overexpressed and activated in metastatic breast cancers. Monoclonal antibodies targeting Her2, such as trastuzumab and pertuzumab, have become important targeted therapies for patients with HER2-positive breast cancer. Both trastuzumab and pertuzumab can reduce Her2 positive tumor burden by inhibiting Her2 signaling and inducing ADCC activities (antibody dependent cell-mediated cytotoxicity). In this study, we have generated a bispecific antibody, Her2(Per)-S-Fab, by linking the pertuzumab Fab to an anti-CD16 single domain antibody...
January 2018: Journal of Immunotherapy
https://www.readbyqxmd.com/read/29231715/nanoscale-structure-property-relationships-of-polyacrylonitrile-cnt-composites-as-a-function-of-polymer-crystallinity-and-cnt-diameter
#7
Jacob R Gissinger, Chandrani Pramanik, Bradley Newcomb, Satish Kumar, Hendrik Heinz
Polyacrylonitrile (PAN)/carbon nanotube (CNT) composites are used as a precursor for ultrastrong and lightweight carbon fibers. However, the mechanisms of formation and relationships of the nanoscale structure to mechanical and thermal properties have remained uncertain. This study reports on the impact of different degrees of PAN pre-orientation and CNT diameter on the composite properties using molecular dynamics simulation with accurate potentials and comparisons to experimental data. Relationships between the atomically resolved structure, thermal, and mechanical properties are derived...
December 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29231615/-effects-of-different-methods-of-acupuncture-and-moxibustion-on-functional-constipation-in-rats-a-comparative-study
#8
Jing Xu, Yuzhu Du, Xuanping Zhang, Xin Zhang, Haijiao Xing, Lijia Pan, Rui Jia, Chun-Sheng Jia
OBJECTIVE: To compare the effects of acupuncture, electroacupuncture (EA) and moxibustion on functional constipation in rats. METHODS: Sixty male Sprague-Dawley rats were divided into a control group (n=8), a model group (n=11), a medication group (n=8), an acupuncture group (n=11), an EA group (n=11) and a moxibustion group (n=11) by random number table. The rats in the model group, medication group, acupuncture group, EA group and moxibustion group were treated with intragastric administration of loperamide hydrochloride for 6 days continuously to establish the functional constipation models, while equal volume of drinking water was administrated to rats in the control group at the same time...
May 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29231609/-manual-acupuncture-versus-electroacupuncture-for-menopausal-syndrome-a-randomized-controlled-trial
#9
Caiyuzhu Wen, Yafei Liu, Xiaoli Pan, Zhen Mao, Li Zhou, Hongxing Zhang
OBJECTIVE: To compare the clinical therapeutic effects and safety on menopausal symptoms between manual acupuncture (MA) and electroacupuncture (EA). METHODS: Fifty patients were randomized into an MA group (25 cases) and an EA group (25 cases). In the MA group, the regular needling technique and pseudo-EA were used at Guanyuan (CV 4), Zigong (EX-CA 1), Tianshu (ST 25) and Sanyinjiao (SP 6). In the EA group, the acupoints were the same as the MA group and stimulated with EA and pseudo-MA (no manipulation applied in treatment), with disperse-dense wave, 10 Hz/50 Hz, 0...
May 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29231513/-application-of-data-mining-on-the-relationship-between-deqi-and-effect
#10
Qiuyin Pan, Liangxiao Ma, Yang Yang, Jiang Zhu
OBJECTIVE: To analyze the relationship between deqi and effect by data mining technique with retrieving clinical literature about acupuncture deqi since the founding of the country. METHODS: The modern computerization and data mining technologies were adopted to set up clinical literature about acupuncture deqi database. The relevant clinical literature was collected, screened, extracted, and statistical and correlation analyses were used so as to explore the relationship between deqi and effect...
June 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29231508/-effects-of-tooth-extraction-under-acupuncture-anesthesia
#11
Jiang Pan, Bilian Lin, Ming Chen, Wei Zhang, Bidan Lou
OBJECTIVE: To compare the effects for tooth extraction between acupuncture anesthesia and drug local block anesthesia. METHODS: Sixty patients were randomly assigned into an acupuncture group and a drug group, 30 cases in each one. Acupuncture was applied at Hegu (LI 4), Neiting (ST 44) and the affected side Xiaguan (ST 7), and Jiache (ST 6), etc. Arrachement was used after deqi and the needles were retained for 10 min after tooth extraction in the acupuncture group...
June 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29231336/-clinical-observation-of-peptic-ulcer-treated-with-acupuncture-based-on-theory-of-the-compatibility-of-the-five-meridians-in-huxiang
#12
Cuiying Li, Jinxiang Li, Shimin Pan, Xi Zhang, Ying Li
OBJECTIVE: To compare the effects differences for peptic ulcer between acupuncture based on the theory of "the compatibility of the five meridians" in Huxiang and conventional western medication. METHODS: Sixty patients with peptic ulcer of liver-stomach disharmony type (LSDT) and weakness of spleen and stomach type (WSST) were assigned into an observation group and a control group by block randomization according to syndrome differentiation.Finally,28 cases (17 with LSDT and 11 with WSST) in the observation group,29 cases (18 with LSDT and 11 with WSST) in the control group were included...
August 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29231321/-efficacy-of-acupuncture-moxibustion-periodic-therapy-on-follicular-maldevelopment-differentiated-as-spleen-and-kidney-yang-deficiency
#13
Yuxuan Yan, Chang Pan, Jie Wu, Lijie Yang
OBJECTIVE: To observe the clinical efficacy of acupuncture and moxibustion periodic therapy on folli-cular maldevelopment differentiated as spleen and kidney yang deficiency. METHODS: Sixty patients of follicular maldevelopment differentiated as spleen and kidney yang deficiency were randomized as an observation group and a control group, 30 cases in each one. The conventional acupuncture-moxibustion therapy was used in the control group and the acupuncture-moxibustion periodic therapy was applied to the observation group...
January 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29231226/strong-magnetic-resonances-and-largely-enhanced-second-harmonic-generation-of-colloidal-mos2-and-res2-au-nanoantennas-with-assembled-2d-nanosheets
#14
Si-Jing Ding, Zhi-Jun Luo, Ya-Ming Xie, Gui-Ming Pan, Yun-Hang Qiu, Kai Chen, Li Zhou, Jianfang Wang, Hai-Qing Lin, Qu-Quan Wang
Colloidal disk-like and sphere-like MoS2 nanoantennas are synthesized. They consist of curly and interlaced 2D nanosheets. The resonance peak of the MoS2 nanoantennas can be tuned from 500 to 900 nm by adjusting the size and shape. The strong magnetic and electric resonances of the dielectric antennas are revealed by theoretical calculations with Mie theory. The second harmonic generation (SHG) of the exfoliated nanosheets and the synthesized nanodisks and nanospheres is investigated and compared by scanning the excitation laser wavelength...
December 12, 2017: Nanoscale
https://www.readbyqxmd.com/read/29231135/preparation-characterization-toxicity-and-pharmacodynamics-of-the-inclusion-complex-of-brucea-javanica-oil-with-%C3%AE-cyclodextrin-polymers
#15
Rong-Rong Xu, Lin Chen, Bo Pan, Xing-Chen Wang, Huan-Huan Wu, Xian-Hong Song, Rong Hu
BACKGROUND: The novel water-soluble inclusion complex of Brucea javanica oil (BJO) by β-cyclodextrin polymers (CDP) was prepared by saturated aqueous method and characterized by SEM, FT-IR and 1H NMR. Compared with BJO, the aqueous solubility of BJO-CDP (77.76%) was greatly enhanced due to the water-soluble CDP host. RESULTS: In the acute toxicity test, the value of LD50 of BJO-CDP was 11.94 g/kg, suggesting the lower toxicity of BJO-CDP. Moreover, the pharmacodynamics of BJO-CDP was investigated by evaluating its inhibition effects on human hepatoma SMMC-7721 cells and mice transplantable colon cancer CT-26 cells...
December 11, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29230663/advantages-with-prophylactic-peg-rhg-csf-versus-rhg-csf-in-breast-cancer-patients-receiving-multiple-cycles-of-myelosuppressive-chemotherapy-an-open-label-randomized-multicenter-phase-iii-study
#16
Jie Xie, Jun Cao, Jing-Fen Wang, Bai-Hong Zhang, Xiao-Hua Zeng, Hong Zheng, Yang Zhang, Li Cai, Yu-Dong Wu, Qiang Yao, Xiao-Chun Zhao, Wei-Dong Mao, Ai-Mei Jiang, Shao-Shui Chen, Shun-E Yang, Shu-Sen Wang, Jian-Hong Wang, Yue-Yin Pan, Bi-Yong Ren, Yan-Ju Chen, Li-Zhi Ouyang, Kai-Jian Lei, Jing-Hua Gao, Wen-He Huang, Zhan Huang, Tao Shou, Yan-Ling He, Jing Cheng, Yang Sun, Wei-Ming Li, Shu-de Cui, Xin Wang, Zhi-Guo Rao, Hu Ma, Wei Liu, Xue-Yong Wu, Wei-Xi Shen, Fei-Lin Cao, Ze-Min Xiao, Biao Wu, Shu-Yan Tian, Dong Meng, Peng Shen, Bi-Yun Wang, Zhonghua Wang, Jian Zhang, Leiping Wang, Xi-Chun Hu
BACKGROUND: PEG-rhG-CSF reduces neutropenia and improves chemotherapy safety. In China's registration trial (CFDA: 2006L01305), we assessed its efficacy and safety against rhG-CSF, and prospectively explored its value over multiple cycles of chemotherapy. METHODS: In this open-label, randomized, multicenter phase 3 study, breast cancer patients (n = 569) were randomized to receive PEG-rhG-CSF 100 µg/kg, PEG-rhG-CSF 6 mg, or rhG-CSF 5 µg/kg/d after chemotherapy...
December 11, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29230647/validating-a-continental-scale-groundwater-diffuse-pollution-model-using-regional-datasets
#17
Issoufou Ouedraogo, Pierre Defourny, Marnik Vanclooster
In this study, we assess the validity of an African-scale groundwater pollution model for nitrates. In a previous study, we identified a statistical continental-scale groundwater pollution model for nitrate. The model was identified using a pan-African meta-analysis of available nitrate groundwater pollution studies. The model was implemented in both Random Forest (RF) and multiple regression formats. For both approaches, we collected as predictors a comprehensive GIS database of 13 spatial attributes, related to land use, soil type, hydrogeology, topography, climatology, region typology, nitrogen fertiliser application rate, and population density...
December 11, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29230549/a-nationwide-survey-of-incidence-rates-and-risk-factors-of-inguinal-hernia-in-preterm-children
#18
Yu-Wei Fu, Mei-Lien Pan, Yao-Jen Hsu, Tai-Wai Chin
PURPOSE: Clinical observations showed a higher incidence rate of inguinal hernia (IH) in preterm infants. In this study, we calculated the incidence rate of preterm IH from the National Health Insurance Research Database (NHIRD) of Taiwan. METHODS: From NHIRD, 92,308 subjects born in the year of 1997-2005 were randomly selected as the study cohort. The medical claims of these subjects from birth to 6th year of age were analyzed. Preterm births were defined using ICD code 765...
December 11, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/29230348/a-randomized-two-way-crossover-study-to-evaluate-the-pharmacokinetics-of-caffeine-delivered-using-caffeinated-chewing-gum-versus-a-marketed-caffeinated-beverage-in-healthy-adult-volunteers
#19
Paul Sadek, Xiao Pan, Phil Shepherd, Elise Malandain, John Carney, Hugh Coleman
Background: This study was conducted to compare the pharmacokinetics of caffeine delivered using caffeinated chewing gum to that delivered using a marketed caffeinated beverage (instant coffee) in 16 healthy adult volunteers. Materials and Methods: This was a controlled open-label, randomized, two-period crossover study. Caffeinated chewing gum and a serving of instant coffee, each containing ∼50 mg caffeine, were administered with blood samples collected before and up to 24 hours after administration starts...
December 1, 2017: Journal of Caffeine Research
https://www.readbyqxmd.com/read/29230304/coil-embolization-for-intrahepatic-haemorrhage-following-liver-biopsy-in-a-patient-with-hepatitis-c-virus-infection-and-hepatic-microaneurysms
#20
Apostolos Koffas, John Karani, Roger Williams
Intrahepatic bleeding secondary to rupture of hepatic microaneurysms is an uncommon clinical entity more frequently associated with polyarteritis nodosa (PAN) or rarely with other vasculitis or autoimmune disease. Hepatic vasculitis is reported in chronic hepatitis C virus (HCV) infection and an association between hepatitis C and PAN is described. The current report presents the case of a middle-aged female patient with a medical history remarkable for HCV infection who underwent a percutaneous liver biopsy, which was complicated by severe intrahepatic and perihepatic haemorrhage...
December 2017: Oxford Medical Case Reports
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