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https://www.readbyqxmd.com/read/28332442/ultrasound-imaging-in-the-diagnosis-of-large-vessel-vasculitis
#1
Michael Czihal, Christian Lottspeich, Ulrich Hoffmann
Nowadays noninvasive vascular imaging has an important role in the diagnostic work-up of the large vessel vasculitides (LVV), most importantly giant cell arteritis (GCA) and Takayasu arteritis. Among the imaging modalities available, ultrasound (US) has several important advantages, including low costs, rapid and repetitive availability without exposure to radiation, and high spatial resolution for assessment of large and medium-sized arteries. Therefore, US can be regarded the first line imaging method in suspected LVV...
March 23, 2017: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/28323232/suspected-giant-cell-aortitis-from-multiple-aortic-structural-damage-to-fatal-listeria-sepsi-a-case-report
#2
Valeria Silvestri, Giacomo Isernia
Giant cell arteritis ( GCA) is an inflammatory vasculopathy affecting large and middle-sized vessels , specifically cranial arteries derived from carotid artery. Isolated extracranial vessel involvement can occur. Interest in extravascular manifestations is recently increasing because of diffusion of sensitive and specific imaging tools such as 18FDG PET TC . Patients have an increased relative risk of severe infection. Listeria monocytogenes infection risk is increased, and vascular system involvement and graft infection have been, even though rarely, reported...
March 16, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28320119/giant-cell-arteritis-following-varicella-zoster-vaccination
#3
Itay Lotan, Israel Steiner
BACKGROUND: Giant cell arteritis (GCA) is a form of large-vessel vasculitis affecting patients older than 50years old. Recent reports have suggested that the condition is caused by reactivation of varicella zoster virus (VZV). If that is indeed the case, a vaccine that prevents VZV reactivation should reduce the incidence of GCA. To further test that hypothesis, we assessed the incidence of GCA among patients older than 50years of age who were vaccinated against VZV and compared it to GCA incidence in the general population...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28319273/gastric-microbiota-features-associated-with-cancer-risk-factors-and-clinical-outcomes-a-pilot-study-in-gastric-cardia-cancer-patients-from-shanxi-china
#4
Guoqin Yu, Nan Hu, Lemin Wang, Chaoyu Wang, Xiao-You Han, Mike Humphry, Jacques Ravel, Christian C Abnet, Philip R Taylor, Alisa M Goldstein
Little is known about the link between gastric microbiota and the epidemiology of gastric cancer. In order to determine the epidemiologic and clinical relevance of gastric microbiota, we used 16S ribosomal RNA gene sequencing analysis to characterize the composition and structure of the gastric microbial community of 80 paired samples (non-malignant and matched tumor tissues) from gastric cardia adenocarcinoma (GCA) patients in Shanxi, China. We also used PICRUSt to predict microbial functional profiles. Compared to patients without family history of upper gastrointestinal (UGI) cancer in the non-malignant gastric tissue microbiota, patients with family history of UGI cancer had higher Helicobacter pylori (Hp) relative abundance (median: 0...
March 20, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28315516/metaplastic-ossification-of-the-temporal-artery-with-osteoclast-like-giant-cells-a-mimicker-of-giant-cell-temporal-arteritis
#5
Miroslav Sekulic, Alexander M Truskinovsky
PURPOSE: To describe a patient presenting with suspected giant cell (temporal) arteritis (GCA) in whom subsequent temporal artery biopsy showed luminal narrowing by medial calcification, metaplastic ossification, and fibrointimal proliferation, consistent with calciphylaxis. METHODS: A 55-year-old man with end-stage renal disease presented with unilateral loss of vision and elevated erythrocyte sedimentation rate and was initially treated as though he had GCA; however, a subsequent temporal artery biopsy showed marked luminal narrowing by medial calcification, metaplastic ossification, and fibrointimal proliferation, consistent with calciphylaxis...
February 28, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28314758/immune-checkpoint-dysfunction-in-medium-and-large-vessel-vasculitis
#6
Ryu Watanabe, Hui Zhang, Gerald Berry, Jorg J Goronzy, Cornelia M Weyand
Giant cell arteritis (GCA) is a granulomatous vasculitis of the aorta and its medium-sized branch vessels. CD4 T-cells, macrophages and dendritic cells build granulomatous infiltrates that injure the vessel wall and elicit a maladaptive response-to-injury. Pathologic consequences include fragmentation of elastic membranes, destruction of the medial layer, microvascular neoangiogenesis, massive outgrowth of myofibroblasts, and lumen-occlusive intimal hyperplasia. Antigens have been suspected to drive the local activation of vasculitogenic CD4 T-cells, but recent data suggest a more generalized defect in the threshold setting of such T-cells, rendering them hyperreactive...
March 17, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28301035/comparison-among-the-efficacy-of-interventions-for-the-return-rate-to-receive-the-pap-test-report-randomized-controlled-clinical-trial
#7
Camila Teixeira Moreira Vasconcelos, Ana Karina Bezerra Pinheiro, Ana Izabel Oliveira Nicolau, Thaís Marques Lima, Denise de Fátima Fernandes Barbosa
Objective: to test the effects of a behavioral, an educative and a comparative intervention on women's adherence to the return appointment to receive the pap test report. Methods: randomized controlled clinical trial at a Primary Health Care Service, involving three groups: EG (educative session and test demonstration), BG (recall ribbon) and standard intervention (card containing the return appointment - graphical reminder), called comparative group here (CG). To select the sample, the following was established: having started sexual activity and undergoing the pap smear during the study, resulting in 775 women...
March 2, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/28277489/analysis-of-the-common-genetic-component-of-large-vessel-vasculitides-through-a-meta-immunochip-strategy
#8
F David Carmona, Patrick Coit, Güher Saruhan-Direskeneli, José Hernández-Rodríguez, María C Cid, Roser Solans, Santos Castañeda, Augusto Vaglio, Haner Direskeneli, Peter A Merkel, Luigi Boiardi, Carlo Salvarani, Miguel A González-Gay, Javier Martín, Amr H Sawalha
Giant cell arteritis (GCA) and Takayasu's arteritis (TAK) are major forms of large-vessel vasculitis (LVV) that share clinical features. To evaluate their genetic similarities, we analysed Immunochip genotyping data from 1,434 LVV patients and 3,814 unaffected controls. Genetic pleiotropy was also estimated. The HLA region harboured the main disease-specific associations. GCA was mostly associated with class II genes (HLA-DRB1/HLA-DQA1) whereas TAK was mostly associated with class I genes (HLA-B/MICA). Both the statistical significance and effect size of the HLA signals were considerably reduced in the cross-disease meta-analysis in comparison with the analysis of GCA and TAK separately...
March 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28276953/risk-of-ocular-manifestations-in-patients-with-giant-cell-arteritis-a-nationwide-study-in-sweden
#9
J Ji, I Dimitrijevic, J Sundquist, K Sundquist, B Zöller
OBJECTIVE: No large-scale nationwide study has determined the risk of ocular manifestations in patients with giant cell arteritis (GCA). The aim was to study the incidence and risk factors of ocular manifestations in patients with GCA in Sweden. METHOD: A national cohort was created by linking Swedish nationwide registers. GCA patients were identified from the Swedish Hospital Inpatient and Outpatient Registers between 2002 and 2010, and were followed until the development of ocular manifestations...
February 22, 2017: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/28274481/no-detection-of-varicella-zoster-virus-in-temporal-arteries-of-patients-with-giant-cell-arteritis
#10
Francesco Muratore, Stefania Croci, Ione Tamagnini, Alessandro Zerbini, Salvatore Bellafiore, Lucia Belloni, Luigi Boiardi, Alessandra Bisagni, Nicolò Pipitone, Maria Parmeggiani, Alberto Cavazza, Carlo Salvarani
OBJECTIVE: Data on the presence of varicella-zoster virus (VZV) in temporal arteries of patients with giant cell arteritis (GCA) are controversial. We analyzed VZV infection in temporal arteries from Italian patients with temporal artery biopsy (TAB)-positive GCA, TAB-negative GCA, and controls. METHODS: A total of 79 formalin-fixed, paraffin-embedded (FFPE) TABs performed between 2009 and 2012 at a single institution from 34 TAB-positive GCA patients, 15 TAB-negative GCA patients, and 30 controls were retrieved...
February 10, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28271439/relation-of-visual-creative-imagery-manipulation-to-resting-state-brain-oscillations
#11
Yuxuan Cai, Delong Zhang, Bishan Liang, Zengjian Wang, Junchao Li, Zhenni Gao, Mengxia Gao, Song Chang, Bingqing Jiao, Ruiwang Huang, Ming Liu
Visual creative imagery (VCI) manipulation is the key component of visual creativity; however, it remains largely unclear how it occurs in the brain. The present study investigated the brain neural response to VCI manipulation and its relation to intrinsic brain activity. We collected functional magnetic resonance imaging (fMRI) datasets related to a VCI task and a control task as well as pre- and post-task resting states in sequential sessions. A general linear model (GLM) was subsequently used to assess the specific activation of the VCI task compared with the control task...
March 7, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28244857/diagnostic-validity-of-doppler-ultrasound-in-giant-cell-arteritis
#12
I Concepción Aranda-Valera, Sara García Carazo, Irene Monjo Henry, Eugenio De Miguel Mendieta
OBJECTIVES: To assess the validity of Doppler ultrasound in the diagnosis of giant cell arteritis (GCA), using the American College of Rheumatology (ACR) criteria and biopsy and using as gold standard the patient's definitive clinical diagnosis. METHODS: An observational, descriptive and analytical study of 451 consecutive patients with suspected GCA was conducted, and the clinical history and ultrasound findings of the patients were reviewed. The validity of ACR criteria, temporal arteritis biopsy (TAB) and Doppler ultrasound in the diagnosis of GCA was calculated using the final diagnosis of the doctor in charge as the gold standard...
February 28, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28229964/csfv-proliferation-is-associated-with-gbf1-and-rab2
#13
Wulong Liang, Minping Zheng, Changlei Bao, Yanming Zhang
The Golgi apparatus and its resident proteins are utilized and regulated by viruses to facilitate their proliferation. In this study, we investigated Classical swine fever virus (CSFV) proliferation when the function of the Golgi was disturbed. Golgi function was disturbed using chemical inhibitors, namely, brefeldin A (BFA) and golgicide A (GCA), and RNA interfering targets, such as the Golgi-specific BFA-resistance guanine nucleotide exchange factor 1 (GBF1) and Rab2 GTPases. CSFV proliferation was significantly inhibited during RNA replication and viral particle generation after BFA and GCA treatment...
March 2017: Journal of Biosciences
https://www.readbyqxmd.com/read/28228768/genome-wide-single-nucleotide-polymorphisms-in-cms-and-restorer-lines-discovered-by-genotyping-using-sequencing-and-association-with-marker-combining-ability-for-12-yield-related-traits-in-oryza-sativa-l-subsp-japonica
#14
Imdad U Zaid, Weijie Tang, Erbao Liu, Sana U Khan, Hui Wang, Edzesi W Mawuli, Delin Hong
Heterosis or hybrid vigor is closely related with general combing ability (GCA) of parents and special combining ability (SCA) of combinations. The evaluation of GCA and SCA facilitate selection of parents and combinations in heterosis breeding. In order to improve combining ability (CA) by molecular marker assist selection, it is necessary to identify marker loci associated with the CA. To identify the single nucleotide polymorphisms (SNP) loci associated with CA in the parental genomes of japonica rice, genome-wide discovered SNP loci were tested for association with the CA of 18 parents for 12 yield-related traits...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28202913/vasculitis-syndromes-loss-of-immunoinhibitory-checkpoint-implicated-in-gca
#15
Sarah Onuora
No abstract text is available yet for this article.
March 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28196067/body-weight-trajectories-and-risk-of-oesophageal-and-gastric-cardia-adenocarcinomas-a-pooled-analysis-of-nih-aarp-and-plco-studies
#16
Jessica L Petrick, Scott P Kelly, Linda M Liao, Neal D Freedman, Barry I Graubard, Michael B Cook
BACKGROUND: Elevated body mass index (BMI, kg m(-2)) has been consistently associated with oesophageal adenocarcinoma (EA) and gastric cardia adenocarcinoma (GCA) incidence. However, effects of adiposity over the life course in relation to EA/GCA have not been thoroughly explored. METHODS: We pooled two prospective cohort studies: NIH-AARP Diet and Health Study and Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, with data on 409 796 individuals (633 EA, 415 GCA)...
February 14, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28138903/the-treatment-of-giant-cell-arteritis
#17
REVIEW
Imran Jivraj, Madhura Tamhankar
Giant cell arteritis (GCA) is a systemic inflammatory vasculitis affecting medium and large vessels with potentially sight and life-threatening complications. Early diagnosis and prompt treatment are imperative in order to prevent vision loss and progression of the disease. Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) are inflammatory markers which are elevated in the majority of patients and support the diagnosis of GCA among patients who present with typical symptoms. GCA is confirmed with superficial temporal artery biopsy which demonstrates characteristic pathological findings...
January 2017: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/28134073/long-term-continuation-of-methotrexate-therapy-in-giant-cell-arteritis-patients-in-clinical-practice
#18
Leticia Leon, Luis Rodriguez-Rodriguez, Dalifer Freites, Lucia Arietti, Inmaculada Morado, Cristina Vadillo, José Ramón Lamas, Benjamin Fernandez, Juan Angel Jover, Lydia Abasolo
OBJECTIVES: To assess the long-term continuation of MTX in a cohort of patients with GCA in daily clinical practice. Factors associated with its discontinuation rate were also investigated. METHODS: A longitudinal study from 1991-2014, was performed. GCA patients with MTX and followed-up in a rheumatology outpatient clinic of Madrid during the study period were included. PRIMARY OUTCOME: discontinuation of MTX due to: adverse drug reaction (ADR moderate and severe); inefficacy; sustained clinical response; patient decision...
January 23, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28133925/a-randomized-double-blind-trial-of-abatacept-ctla-4ig-for-the-treatment-of-giant-cell-arteritis
#19
Carol A Langford, David Cuthbertson, Steven R Ytterberg, Nader Khalidi, Paul A Monach, Simon Carette, Philip Seo, Larry W Moreland, Michael Weisman, Curry L Koening, Antoine G Sreih, Robert Spiera, Carol A McAlear, Kenneth J Warrington, Christian Pagnoux, Kathleen McKinnon, Lindsy J Forbess, Gary S Hoffman, Renée Borchin, Jeffrey P Krischer, Peter A Merkel
OBJECTIVE: To compare the efficacy of abatacept to that of placebo for the treatment of giant cell arteritis (GCA). METHODS: In this multicenter trial, patients with newly diagnosed or relapsing GCA were treated with abatacept 10 mg/kg intravenously on days 1, 15, and 29 and week 8, together with prednisone administered daily. At week 12, patients in remission underwent a double-blinded randomization to continue to receive abatacept monthly or switch to placebo...
January 30, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28123651/the-association-between-poor-sleep-quality-and-global-cortical-atrophy-is-related-to-age-results-from-the-atahualpa-project
#20
Oscar H Del Brutto, Robertino M Mera, Mauricio Zambrano, Pablo R Castillo
Community-dwellers aged ≥60 years enrolled in the Atahualpa Project underwent brain MRI and were interviewed with the Pittsburgh Sleep Quality Index. Of 290 participants, 94 (32%) had poor sleep quality and 143 (49%) had global cortical atrophy (GCA). In a logistic regression model (adjusted for demographics, cardiovascular risk factor, severe edentulism, symptoms of depression, the MoCA score, and neuroimaging signatures of cerebrovascular damage), poor sleep quality was associated with GCA (p=0.004). A multivariate probability model showed that the probability of moderate-to-severe GCA significantly increased in individuals with poor sleep quality aged ≥67 years...
July 2016: Sleep Science
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