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https://www.readbyqxmd.com/read/29028942/association-of-high-evidence%C3%A2-gastric-cancer%C3%A2-susceptibility-loci-and-somatic-gene-expression-levels-with-survival
#1
Hyuna Sung, Nan Hu, Howard H Yang, Carol A Giffen, Bin Zhu, Lei Song, Hua Su, Chaoyu Wang, Dominick M Parisi, Alisa M Goldstein, Philip R Taylor, Paula L Hyland
Eleven high-evidence single-nucleotide polymorphisms (SNPs) at 9 loci for gastric cancer (GC) risk were reported, but their associations with survival remains unknown. In this study, we examined associations between SNP and GC survival by anatomic location and histology among 1147 incident cases from the Shanxi Upper Gastrointestinal Genetics Project. We further examined if SNPs were expression quantitative trait loci (eQTL) in normal and tumor gastric tissues, and whether tumor vs. normal somatic mRNA differences in 126 cases were associated with survival...
September 27, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/29025970/the-arf-gef-gbf1-and-arf4-synergize-with-the-sensory-receptor-cargo-rhodopsin-to-regulate-ciliary-membrane-trafficking
#2
Jing Wang, Theresa Fresquez, Vasundhara Kandachar, Dusanka Deretic
The small GTPase Arf4 and the Arf GTPase activating protein (GAP) ASAP1 cooperatively sequester sensory receptor cargo into transport carriers targeted to primary cilia, but the input that drives Arf4 activation in this process remains unknown. Here, we show that during the carrier biogenesis from the photoreceptor Golgi/trans-Golgi network (TGN) a functional complex is formed between Arf4, the Arf guanine nucleotide exchange factor (GEF) GBF1 and the light-sensing receptor, rhodopsin. Rhodopsin and Arf4 bind the regulatory N-terminal DCB-HUS domain of GBF1...
October 12, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/29020715/diagnosis-and-management-of-polymyalgia-rheumatica
#3
Olwyn Jones, Fraser Birrell
Polymyalgia rheumatica (PMR) is a common inflammatory condition of unknown aetiology with a prevalence of 1 in 133 in the over 50s, and a female to male ratio of 2:1. Symptoms develop over a matter of weeks; typically bilateral shoulder or pelvic girdle pain and stiffness, that is worse in the mornings. Associated symptoms include low-grade fever, malaise, fatigue, low mood, poor appetite, and weight loss. There is no specific diagnostic test for PMR but the usual pattern is a commensurate rise in CRP and ESR...
December 2016: Practitioner
https://www.readbyqxmd.com/read/28994265/recognition-of-giant-cell-arteritis-in-patients-with-polymyalgia-rheumatica-who-have-a-stroke-a-cautionary-tale
#4
Donald H Gutteridge, Frank L Mastaglia
An 82-year-old woman with polymyalgia rheumatica (PMR) on prednisone 7 mg daily was admitted to an acute stroke unit with a right homonymous hemianopia, a left posterior cerebral artery occlusion and occipital lobe infarct. She had raised inflammatory markers, did not have a temporal artery biopsy, and was discharged on the same dose of prednisone. After 21 months, off prednisone, her ophthalmologist, concerned about giant cell arteritis (GCA), restarted prednisone 40 mg daily, with rapid, profound visual improvement...
October 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28987704/the-role-of-colour-doppler-ultrasonography-of-facial-and-occipital-arteries-in-patients-with-giant-cell-arteritis-a-prospective-study
#5
Rok Ješe, Žiga Rotar, Matija Tomšič, Alojzija Hočevar
OBJECTIVE: Colour Doppler Sonography (CDS) in giant cell arteritis (GCA) allows the study of involvement of cranial arteries other than the temporal arteries, which are inconvenient to biopsy, such as the facial (FaA), and occipital (OcA) arteries. We aimed to estimate the frequency of the FaA, and OcA involvement in GCA; and to explore the clinical characteristics of these subgroups of patients. METHODS: From 1 January 2014 to 31 December 2016 we prospectively performed a CDS of the FaA, and OcA in addition to the temporal (TA), and the extracranial supra-aortic arteries in all newly diagnosed patients suspected of having GCA...
October 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28983306/genomic-prediction-of-sunflower-hybrids-oil-content
#6
Brigitte Mangin, Fanny Bonnafous, Nicolas Blanchet, Marie-Claude Boniface, Emmanuelle Bret-Mestries, Sébastien Carrère, Ludovic Cottret, Ludovic Legrand, Gwenola Marage, Prune Pegot-Espagnet, Stéphane Munos, Nicolas Pouilly, Felicity Vear, Patrick Vincourt, Nicolas B Langlade
Prediction of hybrid performance using incomplete factorial mating designs is widely used in breeding programs including different heterotic groups. Based on the general combining ability (GCA) of the parents, predictions are accurate only if the genetic variance resulting from the specific combining ability is small and both parents have phenotyped descendants. Genomic selection (GS) can predict performance using a model trained on both phenotyped and genotyped hybrids that do not necessarily include all hybrid parents...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28981882/electroconvulsive-therapy-selectively-enhanced-feedforward-connectivity-from-fusiform-face-area-to-amygdala-in-major-depressive-disorder
#7
Jiaojian Wang, Qiang Wei, Tongjian Bai, Xiaoqin Zhou, Hui Sun, Benjamin Becker, Yanghua Tian, Kai Wang, Keith Kendrick
Electroconvulsive therapy (ECT) has been widely used to treat the major depressive disorder (MDD), especially for treatment resistant depression. However, the neuroanatomical basis of ECT remains an open problem. In our study, we combined the voxel-based morphology (VBM), resting-state functional connectivity (RSFC), and granger causality analysis (GCA) to identify the longitudinal changes of structure and function in 23 MDD patients before and after ECT. In addition, multivariate pattern analysis using linear support vector machine (SVM) was applied to classify 23 depressed patients from 25 gender, age, and education matched healthy controls...
August 28, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/28973818/incremental-costs-in-giant-cell-arteritis
#8
Michael Mounié, Nadège Costa, Laurent Sailler, Maryse Lapeyre-Mestre, Robert Bourrel, Nicolas Savy, Laurent Molinier, Grégory Pugnet
OBJECTIVES: To assess and compare direct costs between giant cell arteritis (GCA) patients and matched-controls and identify incremental cost drivers. METHODS: We carried out a population-based, retrospective, cohort study using the French National Health Insurance System Database. Cost analysis was performed from the French health insurance perspective and took into account direct medical and non-medical costs (€, 2014). Costs were evaluated according to different cost components and divided into periods of 6 months for the accurate assessment of care consumption...
October 3, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28973781/diallel-crosses-for-resistance-to-macrophomina-phaseolina-and-thanatephorus-cucumeris-on-cowpea
#9
L R L Lima, K J Damasceno-Silva, M A Noronha, D A Schurt, M M Rocha
This study aimed at identifying and selecting through partial diallel analysis, segregating populations of cowpea resistant to Macrophomina phaseolina and Thanatephorus cucumeris, based on the evaluation of general (GCA) and specific combining ability (SCA), involved in the genetic control of resistance. For this reason, 19 grouped cowpea genotypes, considering the resistance to these pathogens, were crossed in partial diallel scheme 14 x 5, during 2013 and 2014. The 70 F2 populations and the 19 parents were evaluated in a greenhouse as the reaction to pathogens, separately...
September 27, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28973727/diallel-analysis-for-technological-traits-in-upland-cotton
#10
D R Queiroz, F J C Farias, J J V Cavalcanti, L P Carvalho, D G Neder, L S S Souza, F C Farias, P E Teodoro
Final cotton quality is of great importance, and it depends on intrinsic and extrinsic fiber characteristics. The objective of this study was to estimate general (GCA) and specific (SCA) combining abilities for technological fiber traits among six upland cotton genotypes and their fifteen hybrid combinations, as well as to determine the effective genetic effects in controlling the traits evaluated. In 2015, six cotton genotypes: FM 993, CNPA 04-2080, PSC 355, TAM B 139-17, IAC 26, and TAMCOT-CAMD-E and fifteen hybrid combinations were evaluated at the Experimental Station of Embrapa Algodão, located in Patos, PB, Brazil...
September 21, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28971957/reciprocal-genetics-identifying-qtls-for-general-and-specific-combining-abilities-in-hybrids-between-multiparental-populations-from-two-maize-zea-mays-l-heterotic-groups
#11
Héloïse Giraud, Cyril Bauland, Matthieu Falque, Delphine Madur, Valérie Combes, Philippe Jamin, Cécile Monteil, Jacques Laborde, Carine Palaffre, Antoine Gaillard, Philippe Blanchard, Alain Charcosset, Laurence Moreau
Several plant and animal species of agricultural importance are commercialized as hybrids to take advantage of the heterosis phenomenon. Understanding the genetic architecture of hybrid performances is therefore of key importance. We developed two multiparental maize (Zea mays L.) populations, each corresponding to an important heterotic group (Dent or Flint) and comprised of six connected biparental segregating populations of inbred lines (802 and 822 lines for each group, respectively) issued from four founder lines...
September 28, 2017: Genetics
https://www.readbyqxmd.com/read/28968695/increased-expression-of-interleukin-22-in-patients-with-giant-cell-arteritis
#12
Alessandro Zerbini, Francesco Muratore, Luigi Boiardi, Francesco Ciccia, Martina Bonacini, Lucia Belloni, Alberto Cavazza, Luca Cimino, Antonio Moramarco, Riccardo Alessandro, Aroldo Rizzo, Maria Parmeggiani, Carlo Salvarani, Stefania Croci
Objectives: GCA is characterized by arterial remodelling driven by inflammation. IL-22 is an attractive cytokine which acts at the crosstalk between immune and stromal cells. We hypothesized that IL-22 might be induced in GCA and might be involved in disease pathogenesis. Methods: Patients subjected to temporal artery biopsies (TABs) naïve from therapy were enrolled: 27 biopsy-proven GCA, 8 biopsy-negative GCA, 21 biopsy-negative non-GCA patients. Expression of IL-22 was determined in TABs by immunohystochemistry, in plasma by ELISA, in peripheral blood mononuclear cells by real-time PCR and flow cytometry...
September 7, 2017: Rheumatology
https://www.readbyqxmd.com/read/28942640/development-of-an-indirect-competitive-elisa-for-glycocholic-acid-based-on-chicken-single-chain-variable-fragment-scfv-antibodies
#13
Xiping Cui, Natalia Vasylieva, Panpan Wu, Bogdan Barnych, Jun Yang, Ding Shen, Qiyi He, Shirley J Gee, Suqing Zhao, Bruce D Hammock
Glycocholic acid (GCA) is an important metabolite of bile acids, whose urine levels are expected to be a specific diagnostic biomarker for hepatocellular carcinoma (HCC). A high-throughput immunoassay for determination of GCA would be of significant advantage and useful for primary diagnosis, surveillance and early detection of HCC. Single-chain variable fragment (scFv) antibodies have several desirable characteristics and are an attractive alternative to traditional antibodies for the immunoassay. Because chicken antibodies possess single heavy and light variable functional domains, it is an ideal framework for simplified generation of recombinant antibodies for GCA detection...
September 25, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28916549/positron-emission-tomography-computerized-tomography-in-newly-diagnosed-patients-with-giant-cell-arteritis-who-are-taking-glucocorticoids
#14
Alison H Clifford, Elana M Murphy, Steven C Burrell, Mathew P Bligh, Ryan F MacDougall, J Godfrey Heathcote, Mathieu C Castonguay, Min S Lee, Kara Matheson, John G Hanly
OBJECTIVE: Large vessel uptake on positron emission tomography/computerized tomography (PET/CT) supports the diagnosis of giant cell arteritis (GCA). Its value, however, in patients without arteritis on temporal artery biopsy and in those receiving glucocorticoids remains unknown. We compared PET/CT results in GCA patients with positive (TAB+) and negative temporal artery biopsies (TAB-), and controls. METHODS: Patients with new clinically diagnosed GCA starting treatment with glucocorticoids underwent temporal artery biopsy and PET/CT...
September 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28914559/bilateral-posterior-scleritis-associated-with-giant-cell-arteritis-a-case-report
#15
Mehmet Erdogan, Nihat Sayin, Dilbade Yıldız Ekinci, Sadik Bayramoglu
AIM: To report a case of bilateral posterior scleritis associated with giant cell arteritis Case Report: A 62-year-old female patient presented with bilateral progressive vision loss was diagnosed with bilateral posterior scleritis. According to clinical signs and symptoms and laboratory testing, Giant cell arteritis was also diagnosed. Within 8 weeks of the corticosteroid treatment, the serous retinal detachments completely resolved and choroidal thickness decreased in both eyes. Visual acuity increased, and the symtoms related to Giant cell arteritis improved...
September 15, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28911987/aortitis-in-giant-cell-arteritis-diagnosis-with-fdg-pet-ct-and-agreement-with-ct-angiography
#16
Mona Hommada, Arsène Mekinian, Pierre-Yves Brillet, Sébastien Abad, Claire Larroche, Robin Dhôte, Olivier Fain, Michael Soussan
OBJECTIVES: To assess the detection rate of aortitis in giant cell arteritis (GCA) with fluorodeoxyglucose positron emission tomography/computed tomography (PET) and to compare the findings with CT angiography (CTA). METHODS: Fifty-two GCA patients and 27 controls were included. GCA patients had a PET scan at diagnosis (35/52) or during relapse (17/52). Concomitant CTA was performed in 35/52 patients. Aortitis was defined as FDG uptake higher than the liver for PET and wall thickness≥3mm for CTA...
September 11, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28905861/giant-cell-arteritis-and-polymyalgia-rheumatica-current-challenges-and-opportunities
#17
REVIEW
Christian Dejaco, Elisabeth Brouwer, Justin C Mason, Frank Buttgereit, Eric L Matteson, Bhaskar Dasgupta
The fields of giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) have advanced rapidly, resulting in a new understanding of these diseases. Fast-track strategies and improved awareness programmes that prevent irreversible sight loss through early diagnosis and treatment are a notable advance. Ultrasonography and other imaging techniques have been introduced into routine clinical practice and there have been promising reports on the efficacy of biologic agents, particularly IL-6 antagonists such as tocilizumab, in treating these conditions...
October 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28904646/participation-in-a-year-long-cure-embedded-into-major-core-genetics-and-cellular-and-molecular-biology-laboratory-courses-results-in-gains-in-foundational-biological-concepts-and-experimental-design-skills-by-novice-undergraduate-researchers
#18
Marcy A Peteroy-Kelly, Matthew R Marcello, Erika Crispo, Zafir Buraei, Daniel Strahs, Marisa Isaacson, Leslie Jaworski, David Lopatto, David Zuzga
This two-year study describes the assessment of student learning gains arising from participation in a year-long curriculum consisting of a classroom undergraduate research experience (CURE) embedded into second-year, major core Genetics and Cellular and Molecular Biology (CMB) laboratory courses. For the first course in our CURE, students used micro-array or RNAseq analyses to identify genes important for environmental stress responses by Saccharomyces cerevisiae. The students were tasked with creating overexpressing mutants of their genes and designing their own original experiments to investigate the functions of those genes using the overexpression and null mutants in the second CURE course...
2017: Journal of Microbiology & Biology Education: JMBE
https://www.readbyqxmd.com/read/28899801/is-pet-ct-essential-in-the-diagnosis-and-follow-up-of-temporal-arteritis
#19
REVIEW
Carlo Salvarani, Alessandra Soriano, Francesco Muratore, Yehuda Shoenfeld, Daniel Blockmans
The increasing availability and improvement of imaging techniques are deeply influencing diagnosis and work-up of patients affected with vasculitis, particularly those with large vessel vasculitis (LVV). Fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET), especially when integrated with computed tomography (CT), is taking hold as a useful diagnostic technique to examine the aorta and the other large vessels in giant cell arteritis (GCA) with concomitant large vessel involvement (LV-GCA). In this paper we examined the progresses performed in this field in the last twenty years and the evidence available so far according to two different points of view ('pros' and 'cons'), in order to give a comprehensive answer to a still open question about the role of PET/CT in the diagnosis and follow-up of GCA...
September 9, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28895041/unmet-needs-in-the-pathogenesis-and-treatment-of-vasculitides
#20
REVIEW
Francesco Muratore, Giulia Pazzola, Alessandra Soriano, Nicolò Pipitone, Stefania Croci, Martina Bonacini, Luigi Boiardi, Carlo Salvarani
Despite the progress in the last years on the field of vasculitides, there are several unmet needs regarding classification, disease activity assessment, predictors of flares and complications, and type of treatment for the different forms. The 1990 American College of Rheumatology (ACR) classification criteria currently used to define giant cell arteritis and Takayasu arteritis were designed to discriminate between different types of vasculitides but not to differentiate vasculitis from other disorders. Recently, efforts have been made to overcome the shortcomings of the ACR criteria...
September 11, 2017: Clinical Reviews in Allergy & Immunology
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