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https://www.readbyqxmd.com/read/28725485/segmentation-errors-in-macular-ganglion-cell-analysis-as-determined-by-optical-coherence-tomography-in-eyes-with-macular-pathology
#1
Rayan A Alshareef, Abhilash Goud, Mikel Mikhail, Hady Saheb, Hari Kumar Peguda, Sunila Dumpala, Shruthi Rapole, Jay Chhablani
BACKGROUND: To evaluate artifacts in macular ganglion cell inner plexiform layer (GCIPL) thickness measurement in eyes with retinal pathology using spectral-domain optical coherence tomography (SD OCT). METHODS: Retrospective analysis of color-coded maps, infrared images and 128 horizontal B-scans (acquired in the macular ganglion cell inner plexiform layer scans), using the Cirrus HD-OCT (Carl Zeiss Meditec, Dublin, CA). The study population included 105 eyes with various macular conditions compared to 30 eyes of 30 age-matched healthy volunteers...
2017: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/28724574/the-microvascular-niche-instructs-t-cells-in-large-vessel-vasculitis-via-the-vegf-jagged1-notch-pathway
#2
Zhenke Wen, Yi Shen, Gerald Berry, Farhad Shahram, Yinyin Li, Ryu Watanabe, Yaping Joyce Liao, Jörg J Goronzy, Cornelia M Weyand
Microvascular networks in the adventitia of large arteries control access of inflammatory cells to the inner wall layers (media and intima) and thus protect the immune privilege of the aorta and its major branches. In autoimmune vasculitis giant cell arteritis (GCA), CD4 T helper 1 (TH1) and TH17 cells invade into the wall of the aorta and large elastic arteries to form tissue-destructive granulomas. Whether the disease microenvironment provides instructive cues for vasculitogenic T cells is unknown. We report that adventitial microvascular endothelial cells (mvECs) perform immunoregulatory functions by up-regulating the expression of the Notch ligand Jagged1...
July 19, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28724479/holocene-selection-for-variants-associated-with-general-cognitive-ability-comparing-ancient-and-modern-genomes
#3
Michael A Woodley, Shameem Younuskunju, Bipin Balan, Davide Piffer
Human populations living during the Holocene underwent considerable microevolutionary change. It has been theorized that the transition of Holocene populations into agrarianism and urbanization brought about culture-gene co-evolution that favored via directional selection genetic variants associated with higher general cognitive ability (GCA). To examine whether GCA might have risen during the Holocene, we compare a sample of 99 ancient Eurasian genomes (ranging from 4.56 to 1.21 kyr BP) with a sample of 503 modern European genomes (Fst = 0...
August 2017: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/28713428/clinically-apparent-arterial-thrombosis-in-persons-with-systemic-vasculitis
#4
Alexander Tsoukas, Sasha Bernatsky, Lawrence Joseph, David L Buckeridge, Patrick Bélisle, Christian A Pineau
OBJECTIVE: To estimate the incidence rate of clinically apparent arterial thrombotic events and associated comorbidities in patients with primary systemic vasculitis. METHODS: Using large cohort administrative data from Quebec, Canada, we identified patients with vasculitis, including polyarteritis nodosa (PAN) and granulomatosis with polyangiitis (GPA). Incident acute myocardial infarctions (AMIs) and cerebrovascular accidents (CVAs) after the diagnosis of vasculitis were ascertained in the PAN and GPA group via billing and hospitalization data...
2017: International Journal of Rheumatology
https://www.readbyqxmd.com/read/28709491/band-pattern-analysis-of-mutations-in-rifampicin-resistance-strain-of-mycobacterium-tuberculosis-by-line-probe-assay-in-patients-from-delhi-india
#5
Himanshu Vashistha, M Hanif, K K Chopra, Ashwani Khanna, Divya Shrivastava
BACKGROUND: The GenoType MTBDRplus, a commercial Line Probe Assay (LPA) kit from Hain Lifescience, Germany, is endorsed by India's RNTCP Program for diagnosis of DRTB cases among smear-positive sputum samples. Although the LPA has been studied in several laboratories, there is a wide variation in existing M. tuberculosis strains across the globe, and false results can occur due to the presence of unique genetic mutations in different settings. AIM AND OBJECTIVE: An attempt was made to carry out band pattern analysis using LPA and also to observe uncommon mutations in MDR strains...
July 2017: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/28705403/symptomatic-lower-limb-giant-cell-arteritis-characteristics-management-and-long-term-outcome
#6
C Le Hello, L Auboire, L Berger, D Gouicem, M T Barrellier, S Duthois
OBJECTIVE: To describe characteristics and long-term outcomes of the rare symptomatic lower-limb giant-cell arteritis (LL-GCA). METHODS: Retrospective analysis of 8 patients (6 women; mean±SD age, 63.6±10.9 years; follow-up, 137.3±57.3 months). RESULTS: Four patients satisfied≥3 American College of Rheumatology (ACR) GCA-classification criteria; 4 had<3 criteria and histological LL-GCA proof or associated typical upper-limb involvement...
May 2017: J Med Vasc
https://www.readbyqxmd.com/read/28692118/selection-of-maize-inbred-lines-and-gene-expression-for-resistance-to-ear-rot
#7
G S Pereira, R G V Pinho, E V R V Pinho, L P M Pires, L A Y Bernardo Junior, J L A Pereira, M P Melo
In recent years, there has been a large incidence of fungi causing "ear rot" in maize in Brazil, the main fungus being Fusarium verticillioides. The most efficient and competitive alternative for control of this disease consists of using maize hybrids resistant to this pathogen. Thus, the aims of this study were to analyze the genetic variability of maize inbred lines in regard to resistance to ear rot to observe if there is a maternal effect to resistance to ear rot, to study genetic control of the traits evaluated in hybrids originating from inbred lines of the maize breeding program at the Agriculture Department of Universidade Federal de Lavras (Lavras, MG, Brazil), and characterize the gene expression pattern related to the plant defense mechanism against F...
July 6, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28690507/the-relationship-between-intrinsic-couplings-of-the-visual-word-form-area-with-spoken-language-network-and-reading-ability-in-children-and-adults
#8
Yu Li, Linjun Zhang, Zhichao Xia, Jie Yang, Hua Shu, Ping Li
Reading plays a key role in education and communication in modern society. Learning to read establishes the connections between the visual word form area (VWFA) and language areas responsible for speech processing. Using resting-state functional connectivity (RSFC) and Granger Causality Analysis (GCA) methods, the current developmental study aimed to identify the difference in the relationship between the connections of VWFA-language areas and reading performance in both adults and children. The results showed that: (1) the spontaneous connectivity between VWFA and the spoken language areas, i...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28680624/giant-cell-arteritis-with-polymyalgia-rheumatica-on-fdg-pet-ct
#9
Akira Baba, Kimiichi Uno, Yumi Okuyama, Yohei Munetomo, Shintaro Nakajima, Kennosuke Mizushina, Hideto Kameda
If there is no pain in the temporal artery, the diagnosis of giant cell arteritis (GCA) may be delayed and blindness may occur. Therefore, FDG-PET/CT is important as a modality for diagnosis of GCA. When GCA is suspected and F-18 FDG-PET/CT is performed, it is worthwhile to pay attention to shoulder and hip joints as polymyalgia rheumatica commonly presents with GCA.
July 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28680132/visual-loss-and-other-cranial-ischaemic-complications-in-giant-cell-arteritis
#10
REVIEW
Alessandra Soriano, Francesco Muratore, Nicolò Pipitone, Luigi Boiardi, Luca Cimino, Carlo Salvarani
Giant cell arteritis (GCA) is the most common form of vasculitis in individuals aged 50 years and over. GCA typically affects large and medium-sized arteries, with a predilection for the extracranial branches of the carotid artery. Patients with GCA usually present with symptoms and signs that are directly related to the artery that is affected, with or without constitutional manifestations. The most dreaded complication of GCA is visual loss, which affects about one in six patients and is typically caused by arteritis of the ophthalmic branches of the internal carotid artery...
July 6, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28678751/association-between-cd40-rs1883832-and-immune-related-diseases-susceptibility-a-meta-analysis
#11
Jiaxuan Qin, Jinchun Xing, Rongfu Liu, Bin Chen, Yuedong Chen, Xuan Zhuang
BACKGROUND/OBJECTIVE: It has been reported that CD40 rs1883832 might be associated with immune-related diseases susceptibility. Owing to mixed and inconclusive results, we conducted a meta-analysis of case-control studies to summarize and clarify this association.Methods/main results: A systematic search of studies on the association between CD40 rs1883832 and immune-related diseases susceptibility was conducted in databases. Odds ratios and 95% confidence intervals were used to pool the effect size...
June 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28667859/global-concentration-additivity-and-prediction-of-mixture-toxicities-taking-nitrobenzene-derivatives-as-an-example
#12
Tong Li, Shu-Shen Liu, Rui Qu, Hai-Ling Liu
The toxicity of a mixture depends not only on the mixture concentration level but also on the mixture ratio. For a multiple-component mixture (MCM) system with a definite chemical composition, the mixture toxicity can be predicted only if the global concentration additivity (GCA) is validated. The so-called GCA means that the toxicity of any mixture in the MCM system is the concentration additive, regardless of what its mixture ratio and concentration level. However, many mixture toxicity reports have usually employed one mixture ratio (such as the EC50 ratio), the equivalent effect concentration ratio (EECR) design, to specify several mixtures...
June 28, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28663795/temporal-artery-biopsy-in-the-diagnosis-of-giant-cell-arteritis-does-the-end-justify-the-means
#13
K Bowling, J Rait, J Atkinson, G Srinivas
BACKGROUND: Early temporal artery biopsy is recommended in all patients with suspected cranial GCA (Giant Cell Arteritis) by the BSR (British Society of Rheumatology) and BHPR (British Health Professionals in Rheumatology) guidelines. This should be performed within one week ideally. AIM: To assess ACR (American College of Rheumatology) score at presentation and whether temporal artery biopsy result affects clinical management of the clinically suspected GCA patient...
August 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28658131/polymyalgia-rheumatica-and-giant-cell-arteritis-three-challenges-consequences-of-the-vasculitis-process-osteoporosis-and-malignancy-a-prospective-cohort-study-protocol
#14
Amir Emamifar, Søren Hess, Oke Gerke, Anne Pernille Hermann, Helle Laustrup, Per Syrak Hansen, Peter Thye-Rønn, Niels Marcussen, Frank Svendstrup, Rannveig Gildberg-Mortensen, Jacob Christian Bang, Ziba Ahangarani Farahani, Stavros Chrysidis, Pia Toftegaard, Rikke Asmussen Andreasen, Sebastian le Greves, Hanne Randi Andersen, Rudolf Nezlo Olsen, Inger Marie Jensen Hansen
INTRODUCTION: Polymyalgia rheumatica (PMR) and giant cell arteritis (GCA) are common inflammatory conditions. The diagnosis of PMR/GCA poses many challenges since there are no specific diagnostic tests. Recent literature emphasizes the ability of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) to assess global disease activity in inflammatory diseases. 18F-FDG PET/CT may lead to the diagnosis at an earlier stage than conventional imaging and may also assess response to therapy...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28655311/diagnostic-delay-for-giant-cell-arteritis-a-systematic-review-and-meta-analysis
#15
James A Prior, Hoda Ranjbar, John Belcher, Sarah L Mackie, Toby Helliwell, Jennifer Liddle, Christian D Mallen
BACKGROUND: Giant cell arteritis (GCA), if untreated, can lead to blindness and stroke. The study's objectives were to (1) determine a new evidence-based benchmark of the extent of diagnostic delay for GCA and (2) examine the role of GCA-specific characteristics on diagnostic delay. METHODS: Medical literature databases were searched from inception to November 2015. Articles were included if reporting a time-period of diagnostic delay between onset of GCA symptoms and diagnosis...
June 28, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28643813/-polymyalgia-rheumatica-diagnostic-and-therapeutic-issues-of-an-apparently-straightforward-disease
#16
Ciro Manzo, Dario Camellino
Polymyalgia rheumatica (PMR) is an inflammatory disease characterized by aching and stiffness in the girdles, which affects typically people over 50 years old and could overlap with giant cell arteritis (GCA) in about 15-20% of cases. Although the diagnosis of PMR is usually considered straightforward, clinicians facing this disease should be aware of its atypical manifestations, which can hamper the correct identification of PMR and, conversely, should be aware of other diseases which may present with polymyalgic features...
May 2017: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/28638968/-large-vessel-vasculitis-giant-cell-arteritis-and-takayasu-arteritis
#17
P M Villiger
According to the Chapel Hill Classification, large vessel vasculitides encompass giant cell arteritis (GCA) and the histologically related Takakaysu arteritis (TAK). The two diseases lack autoantibodies and present with a systemic inflammatory response. GCA typically shows a sudden onset with profound sickness, loss of appetite and of body weight, and temporal headache. Due to the substantial risk of sudden blindness, diagnostic work-up has to be performed immediately and treatment started without delay. A close association between polymyalgia rheumatica (PMR) and GCA is well established...
June 21, 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/28638694/giant-cell-arteritis-polymyalgia-rheumatica-and-late-onset-rheumatoid-arthritis-can-they-be-components-of-a-single-disease-process-in-elderly-patients
#18
REVIEW
Cengiz Korkmaz, Pınar Yıldız
OBJECTIVE: To report two patients with giant cell arteritis (GCA) who developed rheumatoid arthritis (RA) and to review the literature in terms of coexistence of RA, GCA, and polymyalgia rheumatica (PMR). METHODS: We conducted a comprehensive review of the English literature from 1980 to 2015 to analyze data on the coexistence of GCA and RA. The PubMed, Web of Science, Proquest, and Ovid databases were searched for articles using the term RA combined with temporal arteritis, GCA, and PMR...
June 2017: European Journal of Rheumatology
https://www.readbyqxmd.com/read/28623164/thick-corneas-large-pupils-and-a-giant-problem
#19
Francesco Pellegrini, Giovanni Prosdocimo, Daniela Bonsanto, Rod Foroozan
An 87-year-old woman presented 1 month after uneventful cataract surgery with ipsilateral corneal edema. She was diagnosed with pseudophakic bullous keratopathy and scheduled for endothelial transplantation. However, a few days later, she presented with bilateral corneal edema, dilated pupils and further reduction of visual acuity. Neuro-Ophthalmic evaluation disclosed a bilateral ocular ischemic syndrome causing complete visual loss. Temporal artery biopsy was consistent with GCA. Corneal decompensation should be considered as a rare presentation of GCA, that ophthalmologists should suspect in any case of unilateral or bilateral ocular ischemic syndrome...
June 13, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28612195/human-epidermal-growth-factor-receptor-2-in-sri-lankan-gastric-carcinoma-patients-with-clinicopathological-association-and-survival
#20
Duminda Subasinghe, Sivasuriya Sivaganesh, Ananthi Samarsekera, Mariyan Priyanthi Kumarasinghe, Dharmabandhu Nandadeva Samarasekera, Menaka Dilani Samarwickrema Lokuhetty
BACKGROUND: HER2 protein expression indicates adverse prognosis in gastric adenocarcinoma (GCa). GCa HER2 positivity ranges from 10 to 22.8%. Similar data are scarce in South Asia and unavailable in Sri Lanka. AIM: To evaluate HER2 protein expression, its clinicopathological relationship and survival in a Sri Lankan GCa cohort. METHODS: One hundred consecutive GCa patients were recruited prospectively for 2 years. Histological diagnosis was confirmed on endoscopic biopsies/gastrectomy specimens...
June 13, 2017: Digestive Diseases and Sciences
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