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https://www.readbyqxmd.com/read/29676602/tocilizumab-for-the-treatment-of-giant-cell-arteritis
#1
Michael Schirmer, Francesco Muratore, Carlo Salvarani
Giant cell arteritis (GCA) is the most frequent type of vasculitis, occurring in people older than 50 years. So far, treatment has been limited to corticosteroids and methotrexate only. Areas covered: Interleukin-6 (IL-6) plays a role in the pathophysiology of GCA. This review covers recent advances in the treatment of GCA with tocilizumab (TCZ), which specifically binds to both soluble and membrane-bound IL-6R and inhibits IL-6R-mediated signaling. Expert commentary: Two randomized controlled trials recently showed the efficacy of the IL-6 receptors inhibitor monoclonal antibody TCZ for the induction and maintenance of remission in patients with new-onset and relapsing GCA...
April 20, 2018: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29676201/prognosis-and-monitoring-of-giant-cell-arteritis-and-associated-complications
#2
Tanaz A Kermani, Kenneth J Warrington
Giant cell arteritis (GCA) is the most common systemic vasculitis in people over the age of 50 years. Prospective imaging studies in GCA highlight the systemic nature of this vasculitis. Areas covered: This review summarizes literature using PubMed on complications of GCA and its treatment. Emphasis was placed on articles published within the past 5 years. Disease associated complications including vision loss from arteritic anterior ischemic optic neuropathy, large-artery stenoses and ischemia, and, aortic aneurysms and dissections...
April 20, 2018: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29671039/three-days-of-high-dose-glucocorticoid-treatment-attenuates-large-vessel-18f-fdg-uptake-in-large-vessel-giant-cell-arteritis-but-with-a-limited-impact-on-diagnostic-accuracy
#3
Berit Dalsgaard Nielsen, Lars Christian Gormsen, Ib Tønder Hansen, Kresten Krarup Keller, Philip Therkildsen, Ellen-Margrethe Hauge
PURPOSE: To evaluate the in-treatment diagnostic accuracy of FDG PET/CT in large-vessel giant cell arteritis (LV-GCA) by serial scans before and after a short course of high-dose glucocorticoid treatment. METHODS: Twenty-four glucocorticoid-naïve patients with new-onset PET/CT verified LV-GCA (pre-treatment baseline PET) were prospectively included. Excluded were patients with a previous history of GCA or polymyalgia rheumatica, LV-GCA-mimicking conditions and patients on immunosuppressive therapy...
April 18, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29666047/comparison-of-magnetic-resonance-angiography-and-18-f-fluorodeoxyglucose-positron-emission-tomography-in-large-vessel-vasculitis
#4
Kaitlin A Quinn, Mark A Ahlman, Ashkan A Malayeri, Jamie Marko, Ali Cahid Civelek, Joel S Rosenblum, Armin A Bagheri, Peter A Merkel, Elaine Novakovich, Peter C Grayson
OBJECTIVES: To assess agreement between interpretation of magnetic resonance angiography (MRA) and 18 F-fluorodeoxyglucose positron emission tomography (PET) for disease extent and disease activity in large-vessel vasculitis (LVV) and determine associations between imaging and clinical assessments. METHODS: Patients with giant cell arteritis (GCA), Takayasu's arteritis (TAK) and comparators were recruited into a prospective, observational cohort. Imaging and clinical assessments were performed concurrently, blinded to each other...
April 17, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29648680/what-is-the-current-evidence-for-disease-subsets-in-giant-cell-arteritis
#5
REVIEW
Kornelis S M van der Geest, Maria Sandovici, Yannick van Sleen, Jan-Stephan Sanders, Nicolaas A Bos, Wayel H Abdulahad, Coen A Stegeman, Peter Heeringa, Abraham Rutgers, Cees G M Kallenberg, Annemieke M H Boots, Elisabeth Brouwer
Giant cell arteritis (GCA) is an autoimmune vasculitis affecting large and medium-sized arteries. Ample evidence indicates that GCA is a heterogeneous disease in terms of symptoms, immune pathology and response to treatment. In the current review, we discuss the evidence for disease subsets in GCA. We describe clinical and immunological characteristics that may impact the risk for cranial ischemic symptoms, relapse rates and long-term glucocorticoid requirements in GCA patients. In addition, we discuss both proven and putative immunological targets for therapy in GCA patients with an unfavourable prognosis...
April 12, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29629470/biotinylated-single-chain-variable-fragment-based-enzyme-linked-immunosorbent-assay-for-glycocholic-acid
#6
Xiping Cui, Natalia Vasylieva, Ding Shen, Bogdan Barnych, Jun Yang, Qiyi He, Zhengyun Jiang, Suqing Zhao, Bruce D Hammock
Glycocholic acid (GCA) has been identified as a novel selective and sensitive biomarker for hepatocellular carcinoma (HCC). In this work, a recombinant antibody, scFv-G11, which was shown previously to have selective reactivity for GCA, was labeled with biotin using a chemical and an enzymatic method, respectively. The enzymatic method proved superior giving sensitive scFv-biotin preparations. Based on biotinylated scFv against GCA and a biotin-streptavidin system for signal amplification, an indirect competitive biotin-streptavidin-amplified enzyme-linked immunosorbent assay (BA-ELISA) has been established for the sensitive and rapid detection of GCA...
April 9, 2018: Analyst
https://www.readbyqxmd.com/read/29614532/-current-trends-in-diagnosis-and-treatment-of-giant-cell-arteritis
#7
Michael Czihal, Christian Lottspeich, Ulrich Hoffmann
Giant cell arteritis (GCA) is the most common form of the primary large vessel vasculitides and typically occurs in individuals aged ≥ 50 years. This concise review article discusses current trends in the management of GCA, including important developments in sonographic assessment (B-mode sonography, contrast enhanced ultrasound) and medical treatment (biological treatment with the interleukin-6 receptor alpha inhibitor tocilizumab).
April 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29611005/recent-advances-in-giant-cell-arteritis
#8
REVIEW
M Guevara, C S Kollipara
PURPOSE OF REVIEW: Giant cell arteritis (GCA) is the most common systemic vasculitis. GCA is categorized as a granulomatous vasculitis of large and medium size vessels. Majority of the symptoms and signs of GCA result from involvement of the aorta and its branches intra- and extracranial. Temporal artery biopsy continues to be the cardinal diagnostic procedure despite new imaging modalities for diagnosing GCA with cranial involvement. Great advances in awareness have led to improvement in preventing irreversible vision loss due to early diagnosis...
April 2, 2018: Current Rheumatology Reports
https://www.readbyqxmd.com/read/29608772/an-improved-method-for-the-computerised-analysis-of-gr-200a-lif-mg-cu-p-tl-signals
#9
H Cui, K Tang
The profile of the residual signals of LiF:Mg,Cu,P within the region of dosimetric interest was approximated by a cubic curve. The conventional analysis, the GCA developed in CIEMAT and the GCA developed in this laboratory were compared. For GCA developed in this laboratory, the 5 μGy test dose could be well measured even after measurement at 10 mGy and obviously at lower doses. The 20 μGy test dose could be well measured even after measurement at 50 mGy. The residual signals caused by previous irradiations in the case of using only reader anneal can be more effectively eliminated by GCA developed in this laboratory than GCA developed in CIEMAT...
March 28, 2018: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29600479/ct-analysis-of-the-aorta-in-giant-cell-arteritis-a-case-control-study
#10
Pierre Emmanuel Berthod, Serge Aho-Glélé, Paul Ornetti, Olivier Chevallier, Hervé Devilliers, Frédéric Ricolfi, Bernard Bonnotte, Romaric Loffroy, Maxime Samson
OBJECTIVES: Giant cell arteritis (GCA) is a large-vessel vasculitis whose diagnosis is confirmed by temporal artery biopsy. However, involvement of large vessels, especially the aorta, can be shown by imaging, which plays an increasing role in GCA diagnosis. The threshold above which aortic wall thickening, as measured by computed tomography (CT), is considered pathological is controversial, with values ranging from 2 to 3 mm. This study assessed aortic morphology by CT scan and its diagnostic value in GCA...
March 29, 2018: European Radiology
https://www.readbyqxmd.com/read/29594821/tree-nut-peanut-and-peanut-butter-consumption-and-the-risk-of-gastric-and-esophageal-cancer-subtypes-the-netherlands-cohort-study
#11
Lisette Nieuwenhuis, Piet A van den Brandt
BACKGROUND: Nut consumption has been associated with reduced cancer-related mortality. However, it is unclear whether nut consumption also reduces the risk of esophageal and gastric cancer subtypes. We prospectively investigated the relationship of tree nut, peanut, and peanut butter intake with risk of esophageal squamous cell carcinoma (ESCC), esophageal adenocarcinoma (EAC), gastric cardia adenocarcinoma (GCA), and gastric non-cardia adenocarcinoma (GNCA) in the Netherlands Cohort Study...
March 28, 2018: Gastric Cancer
https://www.readbyqxmd.com/read/29588230/associations-between-maternal-cytokine-levels-during-gestation-and-measures-of-child-cognitive-abilities-and-executive-functioning
#12
Mikhail G Dozmorov, Staci D Bilbo, Scott H Kollins, Nancy Zucker, Elizabeth K Do, Julia C Schechter, Junfeng Jim Zhang, Susan Murphy, Cathrine Hoyo, Bernard F Fuemmeler
Preclinical studies demonstrate that environmentally-induced alterations in inflammatory cytokines generated by the maternal and fetal immune system can significantly impact fetal brain development. Yet, the relationship between maternal cytokines during gestation and later cognitive ability and executive function remains understudied. Children (n = 246) were born of mothers enrolled in the Newborn Epigenetic Study - a prospective pre-birth cohort in the Southeastern US. We characterized seven cytokines [IL-1β, IL-4,IL-6, IL-12p70, IL-17A, tumor necrosis factor-α (TNFα), and interferon-γ (IFNγ)] and one chemokine (IL-8) from maternal plasma collected during pregnancy...
March 24, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29582810/evaluation-of-macular-ganglion-cell-analysis-compared-to-retinal-nerve-fiber-layer-thickness-for-preperimetric-glaucoma-diagnosis
#13
Sushmita Kaushik, Pankaj Kataria, Vaibhav Jain, Gunjan Joshi, Srishti Raj, Surinder Singh Pandav
Purpose: To compare the diagnostic ability of the ganglion cell analysis (GCA) and retinal nerve fiber layer (RNFL) protocol on optical coherence tomography (OCT), to diagnose preperimetric glaucoma. Methods: A prospective, cross-sectional study of 275 adult patients including 47 early glaucoma (mean deviation better than -6.0 D), 150 glaucoma suspects (106 with suspicious discs and 44 ocular hypertensive (OHT), and 78 normal controls was done. Eligible participants were scanned with the spectral domain CirrusTM OCT (Carl Zeiss Meditec, Dublin, CA)...
April 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29580854/metabolomics-based-evidence-of-the-hypoglycemic-effect-of-ge-gen-jiao-tai-wan-in-type-2-diabetic-rats-via-uhplc-qtof-ms-analysis
#14
Wenbo Wang, Linlin Zhao, Zhenyu He, Ning Wu, Qiuxia Li, Xinjian Qiu, Lu Zhou, Dongsheng Wang
ETHNOPHARMACOLOGICAL RELEVANCE: Ge-Gen-Jiao-Tai-Wan (GGJTW) formula, derived from traditional Chinese herbal medicine, is composed of Pueraria montana var. lobata (Willd.) Sanjappa & Pradeep (Ge-Gen in Chinese), Coptis chinensis Franch (Huang-Lian), and Cinnamomum cassia (L.) J. Presl (Rou-Gui). GGJTW is used for treatment of diabetes in China, reflecting the potent hypoglycemic effect of its ingredients. However, little is known of the hypoglycemic effect of GGJTW and the underlying metabolic mechanism...
March 23, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29566283/aberrant-methylation-mediated-downregulation-of-long-noncoding-rna-c5orf66-as1-promotes-the-development-of-gastric-cardia-adenocarcinoma
#15
Wei Guo, Ping Lv, Shengnan Liu, Fenglou Xu, Yanli Guo, Supeng Shen, Jia Liang, Gang Kuang, Zhiming Dong
As a long non-coding RNA, C5orf66-AS1 is located at 5q31.1. Downregulation and aberrant hypermethylation of C5orf66-AS1 have been detected in a limited several tumors. However, the biological role and distribution of methylated CpG sites of C5orf66-AS1 in gastric cardia adenocarcinoma (GCA) development and prognosis are poorly clarified. The present study was to investigate the expression status and function of C5orf66-AS1 in GCA, and to detect the distribution of methylated CpG sites within the three CpG islands of the promoter and gene body of C5orf66-AS1, further to clarify its prognostic value in GCA patients...
March 22, 2018: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/29557499/overall-and-cause-specific-mortality-in-giant-cell-arteritis-a-meta-analysis
#16
Y H Lee, G G Song
OBJECTIVE: This study aimed to assess the all-cause and cause-specific standardized mortality ratios (SMRs) in patients with giant cell arteritis (GCA). METHODS: We surveyed studies examining all-cause and/or cause-specific SMRs in patients with GCA compared to the general population, using MEDLINE, EMBASE, Cochrane databases, and manual searches. We then performed a meta-analysis of all-cause, sex-specific, region-specific, and cause-specific SMRs in patients with GCA...
March 20, 2018: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/29554340/mortality-causes-and-trends-associated-with-giant-cell-arteritis-analysis-of-the-french-national-death-certificate-database-1980-2011
#17
Achille Aouba, Solange Gonzalez Chiappe, Mireille Eb, Claire Delmas, Hubert de Boysson, Boris Bienvenu, Grégoire Rey, Alfred Mahr
Objectives: Comprehensive analyses of cause-specific death patterns in GCA are sparse. We studied the patterns and time trends in GCA-related mortality using a large death certificate database. Methods; We obtained multiple-cause-of-death data from the French national death certificate database for 1980-2011. GCA-associated deaths were defined as decedents ⩾55 years old with GCA listed as an underlying or non-underlying cause of death. Time trends of death rates were analysed and the mean age at death with GCA and in the general population ⩾55 years old were calculated...
March 14, 2018: Rheumatology
https://www.readbyqxmd.com/read/29549664/altered-effective-connectivity-anchored-in-the-posterior-cingulate-cortex-and-the-medial-prefrontal-cortex-in-cognitively-intact-elderly-apoe-%C3%AE%C2%B54-carriers-a-preliminary-study
#18
Xiao Luo, Kaicheng Li, Y L Jia, Qingze Zeng, Yeerfan Jiaerken, Tiantian Qiu, Peiyu Huang, Xiaojun Xu, Zhujing Shen, Xiaojun Guan, Jiong Zhou, Chao Wang, J J Xu, Minming Zhang
The APOE ε4 allele is associated with impaired intrinsic functional connectivity in neural networks, especially in the default mode network (DMN). However, effective connectivity (EC) reflects the direct causal effects of one brain region to another, which has rarely been investigated. Recently, Granger causality analysis (GCA) proved suitable for the study of directionality in neuronal interactions. Using GCA, we examined the differences in the EC between the anterior medial prefrontal cortex/posterior cingulate cortex (aMPFC/PCC) and the whole brain in 17 ε4 carrying and 32 non-carrying cognitively intact elderly individuals...
March 17, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29549493/negative-temporal-artery-biopsy-predictive-factors-for-giant-cell-arteritis-diagnosis-and-alternate-diagnoses-of-patients-without-arteritis
#19
Gil Bornstein, Iris Barshack, Nira Koren-Morag, Ilan Ben-Zvi, Nadav Furie, Chagai Grossman
To investigate whether among patients with a negative temporal artery biopsy (TAB) there are clinical features that may differentiate between patients with an eventual diagnosis of giant cell arteritis (GCA) and those without arteritis, and to assess the eventual diagnoses of patients without arteritis. Retrospective analysis of patients with a negative TAB performed between 1/1/2000 and 31/12/2015. Information collected included baseline clinical and laboratory data. Patients' final diagnoses were obtained from medical records...
March 17, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29545449/development-of-giant-cell-arteritis-after-treating-polymyalgia-or-peripheral-arthritis-a-retrospective-case-control-study
#20
Eric Liozon, Hubert de Boysson, François Dalmay, Guillaume Gondran, Holy Bezanahary, Anne-Laure Fauchais, Kim-Heang Ly
OBJECTIVE: We investigated the development of giant cell arteritis (GCA) in patients with prior diagnoses of isolated polymyalgia rheumatica and/or peripheral arthritis (PMR/PA), and the potentially relevant characteristics of both illnesses in such patients. METHODS: We retrospectively compared the features of 67 patients at the onset of PMR/PA, and their outcomes, to those of a random group of 65 patients with PMR/PA who did not develop late GCA. We also compared the features and outcomes of patients with late GCA to those of a random sample of patients with more usual GCA (65 with concurrent PMR/PA and 65 without)...
March 15, 2018: Journal of Rheumatology
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