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https://www.readbyqxmd.com/read/29234910/ultrasonography-of-occipital-arteries-to-diagnose-giant-cell-arteritis-a-case-series-and-literature-review
#1
REVIEW
Jonathan Pinnell, Carl Tiivas, Phillip Perkins, Tim Blake, Shanmugam Saravana, Shirish Dubey
We describe four cases of giant cell arteritis (GCA) that presented with occipital headache in the last 6 months. Typical ultrasound features of GCA were found in the occipital arteries which helped to confirm the diagnosis. One patient had already suffered significant visual loss by the time the diagnosis was made, reflecting the similarity in prognosis to the more typical GCA patients. These cases prompted a review of the literature to evaluate the evidence regarding the use of occipital artery ultrasonography in the investigation of GCA...
December 12, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29230819/genetic-inheritance-of-pulp-colour-and-selected-traits-of-cassava-manihot-esculenta-crantz-at-early-generation-selection
#2
Athanase Nduwumuremyi, Rob Melis, Paul Shanahan, Asiimwe Theodore
BACKGROUND: The early generation selection of cassava quantitative and qualitative traits saves breeding resources as it can shorten breeding schemes. The inheritance analysis provides important breeding information for developing new improved varieties. This study aimed at developing an F1 segregating cassava population and determining mode of gene action of pulp colour and selected traits at early generation selection (F1 seedling and clones). RESULTS: The fifteen families exhibited significant (p<0...
December 12, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29225921/geo-epidemiology-of-temporal-artery-biopsy-positive-giant-cell-arteritis-in-australia-and-new-zealand-is-there-a-seasonal-influence
#3
Elisabeth De Smit, Linda Clarke, Paul G Sanfilippo, Tony R Merriman, Matthew A Brown, Catherine L Hill, Alex W Hewitt
Objective: Previous studies, although inconclusive, have suggested possible associations of environmental risk factors with the development of giant cell arteritis (GCA). We aim to investigate seasonal influence on the incidence of GCA across Australia and New Zealand. Methods: In establishing an international study to investigate the molecular aetiology of GCA, archived temporal artery biopsy (TAB) specimens primarily from Australia and New Zealand were obtained...
2017: RMD Open
https://www.readbyqxmd.com/read/29214973/expression-of-the-small-regulatory-rna-gene-mmgr-is-regulated-negatively-by-ania-and-positively-by-ntrc-in-sinorhizobium-meliloti-2011
#4
Germán Ceizel Borella, Antonio Lagares, Claudio Valverde
In the N2-fixing symbiont of alfalfa root nodules, Sinorhizobium meliloti 2011, the mmgR gene encodes a 77 nt small untranslated RNA (sRNA) that negatively regulates the accumulation of polyhydroxybutyrate (PHB) when the bacterium is grown under conditions of surplus carbon (C) in relation to nitrogen (N). We previously showed that the expression of mmgR is primarily controlled at the transcriptional level and that it depends on the cellular N status, although the regulatory mechanism and the factors involved were unknown...
December 7, 2017: Microbiology
https://www.readbyqxmd.com/read/29202363/quantification-of-glycocholic-acid-in-human-serum-by-stable-isotope-dilution-ultra-performance-liquid-chromatography-electrospray-ionization-tandem-mass-spectrometry
#5
Cheng Guo, Cong Xie, Peili Ding, Guangming Qin, Weimin Mo, Xiaoji Cao, Shu Zheng
A rapid, accurate and sensitive stable isotope dilution ultra performance liquidchromatography electrospray ionization tandem mass spectrometry (ID-UPLC-ESI-MS/MS) method for the determination of glycocholic acid (GCA) in human serum was developed and validated. Serum samples were spiked with D5-glycocholic acid and then pretreated with protein precipitation. The analysis was performed on a Waters BEH C18 column (100 mm×2.1mm, 1.7μm), followed by ESI-MS/MS detection in negative ion mode under multiple reaction monitoring mode...
December 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29200816/multivariable-prediction-model-for-suspected-giant-cell-arteritis-development-and-validation
#6
Edsel B Ing, Gabriela Lahaie Luna, Andrew Toren, Royce Ing, John J Chen, Nitika Arora, Nurhan Torun, Otana A Jakpor, J Alexander Fraser, Felix J Tyndel, Arun Ne Sundaram, Xinyang Liu, Cindy Ty Lam, Vivek Patel, Ezekiel Weis, David Jordan, Steven Gilberg, Christian Pagnoux, Martin Ten Hove
Purpose: To develop and validate a diagnostic prediction model for patients with suspected giant cell arteritis (GCA). Methods: A retrospective review of records of consecutive adult patients undergoing temporal artery biopsy (TABx) for suspected GCA was conducted at seven university centers. The pathologic diagnosis was considered the final diagnosis. The predictor variables were age, gender, new onset headache, clinical temporal artery abnormality, jaw claudication, ischemic vision loss (VL), diplopia, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and platelet level...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29196244/a-concise-review-of-significantly-modified-serological-biomarkers-in-giant-cell-arteritis-as-detected-by-different-methods
#7
REVIEW
B Burja, T Kuret, S Sodin-Semrl, K Lakota, Ž Rotar, R Ješe, K Mrak-Poljsak, P Žigon, G G Thallinger, J Feichtinger, S Čučnik, M Tomšič, S Praprotnik, A Hocevar
Giant cell arteritis (GCA) is a primary systemic vasculitis present in subjects older than 50years with involvement of large and medium sized arteris. Early diagnosis for GCA is essential to prevent serious complications, such as permanent vision loss and/or cerebrovascular events. Elevated inflammatory cytokines, with acute phase and other proteins dominate large- and medium-sized arteries leading to stenosis or occlusion of arterial lumen. To date, there are no reliable serological markers for monitoring GCA...
November 28, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29166756/use-of-imaging-techniques-in-large-vessel-vasculitis-and-related-conditions
#8
Annibale Versari, Nicolò Pipitone, Massimiliano Casali, Francois Jamar, Giulia Pazzola
Giant Cell Arteritis (GCA) and Takayasu's arteritis (TA) are large vessel vasculitis (LVV) primarily affecting the aorta and its major branches, mainly differentiated by the onset age (>50 years GCA and <40 years TA). In addition, temporal artery involvement and polymyalgia rheumatic are typical features of GCA, but not TA. Imaging techniques are required to secure the diagnosis of large-vessel vasculitides, and to monitor the disease course. Both morphological and metabolic imaging are involved. Morphological imaging is represented mainly by Computerized Tomography (CT), CT angiography, Magnetic Resonance (MR), MR angiography, Color-Doppler Sonography (CDS) and high-resolution CDS...
November 22, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29159203/varicella-zoster-virus-infected-cerebrovascular-cells-produce-a-proinflammatory-environment
#9
Dallas Jones, C Preston Neff, Brent E Palmer, Kurt Stenmark, Maria A Nagel
Objective: To test whether varicella zoster virus (VZV) infection of human brain vascular cells and of lung fibroblasts directly increases proinflammatory cytokine levels, consistent with VZV as a causative agent in intracerebral VZV vasculopathy and giant-cell arteritis (GCA). Methods: Conditioned supernatant from mock- and VZV-infected human brain vascular adventitial fibroblasts (HBVAFs), human perineurial cells (HPNCs), human brain vascular smooth muscle cells (HBVSMCs), and human fetal lung fibroblasts (HFLs) were collected at 72 hours postinfection and analyzed for levels of 30 proinflammatory cytokines using the Meso Scale Discovery Multiplex ELISA platform...
September 2017: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29156092/gingival-cyst-of-the-adult-lateral-periodontal-cyst-and-botryoid-odontogenic-cyst-an-updated-systematic-review
#10
REVIEW
Bruno Ramos Chrcanovic, Ricardo Santiago Gomez
OBJECTIVE: To integrate the available data published on gingival cyst of the adult (GCA), lateral periodontal cyst (LPC) and botryoid odontogenic cyst (BOC) into a comprehensive analysis of their clinical/radiologic features. METHODS: An electronic search was undertaken in July/2017. Eligibility criteria included publications having enough clinical/radiological/histological information to confirm the diagnosis. RESULTS: 146 publications (157 GCAs, 213 LPCs, 96 BOCs) were included...
November 20, 2017: Oral Diseases
https://www.readbyqxmd.com/read/29146018/biological-treatments-in-giant-cell-arteritis-takayasu-arteritis
#11
Maxime Samson, Georgina Espígol-Frigolé, Nekane Terrades-García, Sergio Prieto-González, Marc Corbera-Bellalta, Roser Alba-Rovira, José Hernández-Rodríguez, Sylvain Audia, Bernard Bonnotte, Maria C Cid
Giant cell arteritis (GCA) and Takayasu arteritis (TAK) are the two main large vessel vasculitides. They share some similarities regarding their clinical, radiological and histological presentations but some pathogenic processes in GCA and TAK are activated differently, thus explaining their different sensitivity to biological therapies. The treatment of GCA and TAK essentially relies on glucocorticoids. However, thanks to major progress in our understanding of their pathogenesis, the role of biological therapies in the treatment of these two vasculitides is expanding, especially in relapsing or refractory diseases...
November 13, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29145713/positron-emission-tomography-as-an-imaging-biomarker-in-a-prospective-longitudinal-cohort-of-patients-with-large-vessel-vasculitis
#12
Peter C Grayson, Sara Alehashemi, Armin A Bagheri, Ali Cahid Civelek, Thomas R Cupps, Mariana J Kaplan, Ashkan A Malayeri, Peter A Merkel, Elaine Novakovich, David A Bluemke, Mark A Ahlman
OBJECTIVES: To assess the clinical value of (18) F-flurodeoxyglucose (FDG) positron emission tomography (PET) in a prospective cohort of patients with large-vessel vasculitis (LVV) and disease comparators. METHODS: Patients with Takayasu's arteritis (TAK) and giant cell arteritis (GCA) were studied, along with a comparator group consisting of patients with hyperlipidemia, diseases that mimic LVV, and healthy controls. Participants underwent clinical evaluation and FDG-PET imaging, and patients with LVV underwent serial imaging at six-month intervals...
November 16, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29145680/-a-rare-differential-diagnosis-of-chronic-cough
#13
Michael Dicker, Tino Schneider, Johannes von Kempis, Markus Diethelm
History and admission findings We report on a 62-year-old male patient with dry cough for 3 months, constitutional symptoms and elevated inflammatory markers. Investigations Despite extensive diagnostics no infectious, malignant or rheumatologic disease could be found. Bronchoscopy with bronchoalveolar lavage showed lymphocytosis. 18-FDG-PET/CT demonstrated increased metabolic activity of the aorta and its primary branches. Diagnosis, treatment and course We diagnosed large vessel vasculitis consistent to a subtype of giant cell arteritis (GCA) without cranial manifestation...
November 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29140815/neuroimaging-diagnostic-and-monitoring-approaches-in-ophthalmology
#14
Bart K Chwalisz, Marc A Bouffard, Sashank Prasad, Dean M Cestari
PURPOSE OF REVIEW: We review new applications of optical coherence tomography (OCT) technology in neuro-ophthalmology. We also describe new technologies for visualizing the extracranial vessels in the diagnosis of giant cell arteritis (GCA). RECENT FINDINGS: Newer OCT modalities are expanding the evaluation of the optic disc, and are being applied to a number of neurologic conditions such as demyelinating and neurodegenerative disease. Swept-source OCT and enhanced-depth imaging OCT are refining the fine-grained analysis of the optic nerve head in the diagnosis of papilledema and optic nerve drusen...
November 14, 2017: Current Opinion in Neurology
https://www.readbyqxmd.com/read/29134047/middle-and-elementary-school-students-changes-in-self-determined-motivation-in-a-basketball-unit-taught-using-the-tactical-games-model
#15
Stephen Harvey, Alexander Gil-Arias, Megan Lorraine Smith, Lindsey Rachel Smith
Studies examining student motivation levels suggest that this is a significant factor in students' engagement in physical education and may be positively affected when teachers employ alternative pedagogical models such as game-centered approaches (GCAs). The aim of this study was to investigate changes in self-determined motivation of students as they participated in a GCA-basketball unit taught using the Tactical Games Model (TGM). Participants were 173 students (84 girls), 79 middle school (45 girls) and 94 (39 girls) elementary school students from four seventh and five fourth/fifth grade co-educational classes...
October 2017: Journal of Human Kinetics
https://www.readbyqxmd.com/read/29129604/simultaneous-determination-of-nine-kinds-of-dominating-bile-acids-in-various-snake-bile-by-ultrahigh-performance-liquid-chromatography-with-triple-quadrupole-linear-iontrap-mass-spectrometry
#16
Jie Zhang, Yeqin Fan, Yajun Gong, Xiaoyong Chen, Luosheng Wan, Chenggao Zhou, Jiewen Zhou, Shuangcheng Ma, Feng Wei, Jiachun Chen, Jing Nie
Snake bile is one of the most expensive traditional Chinese medicines (TCMs). However, due to the complicated constitutes of snake bile and the poor ultraviolet absorbance of some trace bile acids (BAs), effective analysis methods for snake bile acids were still unavailable, making it difficult to solve adulteration problems. In present study, ultrahigh-performance liquid chromatography with triple quadrupole linear ion trap mass spectrometry (UHPLC-QqQ-MS/MS) was applied to conduct a quantitative analysis on snake BAs...
November 9, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29126277/-18f-fdg-positron-emission-tomography-in-patients-presenting-with-suspicion-of-giant-cell-arteritis-lessons-from-a-vasculitis-clinic
#17
Stephan Imfeld, Christof Rottenburger, Elke Schegk, Markus Aschwanden, Freimut Juengling, Daniel Staub, Mike Recher, Diego Kyburz, Christoph T Berger, Thomas Daikeler
Aims: The usefulness of [18F] fluorodeoxyglucose-positron emission tomography/computed tomography ([18F]FDG-PET/CT) for diagnosing giant cell arteritis (GCA) has been previously reported. Yet, the interpretation of PET scans is not clear-cut. The present study aimed at determining the best method to analyse PET/CT in a large, real-life cohort of patients presenting with suspicion of GCA. Methods and results: One hundred and three patients with clinical suspicion of GCA undergoing PET/CT between 2006 and 2012 were included...
November 8, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29124397/long-term-glucocorticoid-treatment-in-patients-with-polymyalgia-rheumatica-giant-cell-arteritis-or-both-diseases-results-from-a-national-rheumatology-database
#18
Katinka Albrecht, Dörte Huscher, Frank Buttgereit, Martin Aringer, Guido Hoese, Wolfgang Ochs, Katja Thiele, Angela Zink
The objective of this study was to evaluate glucocorticoid (GC) use in patients with polymyalgia rheumatica (PMR), giant cell arteritis (GCA) or both diseases (PMR + GCA) under rheumatological care. Data from patients with PMR (n = 1420), GCA (n = 177) or PMR + GCA (n = 261) from the National Database of the German Collaborative Arthritis Centers were analyzed regarding GCs and related comorbidities (osteoporosis, diabetes and cardiovascular disease), stratified by disease duration (DD). Longitudinal data were analyzed for all patients with a DD ≤ 2 years at database entry (n = 1397)...
November 9, 2017: Rheumatology International
https://www.readbyqxmd.com/read/29122818/optical-coherence-tomographic-angiography-identifies-peripapillary-microvascular-dilation-and-focal-non-perfusion-in-giant-cell-arteritis
#19
Eric D Gaier, Aubrey L Gilbert, Dean M Cestari, John B Miller
AIMS: We set out to determine the optical coherence tomographic angiography (OCT-A) characteristics of arteritic anterior ischaemic optic neuropathy (AAION) in the context of giant cell arteritis (GCA). METHODS: This is an observational case series of four patients with AAION secondary to GCA, three with unilateral AAION and one with bilateral AAION. We reviewed the charts, fundus photography, visual fields, fluorescein angiography (FA) and OCT-A images for all patients to identify a unifying theme in a range of AAION clinical severity...
November 9, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29121248/fusion-of-positron-emission-tomography-computed-tomography-with-magnetic-resonance-imaging-reveals-hamstring-peritendonitis-in-polymyalgia-rheumatica
#20
Claire E Owen, Aurora M T Poon, Sze Ting Lee, Lee Pheng Yap, Richard B Zwar, Christine M McMenamin, Simon K L Lam, David F L Liew, Kunthi Pathmaraj, Andrew Kemp, Andrew M Scott, Russell R C Buchanan
Objectives: To characterize 18F-fluorodeoxyglucose (18F-FDG) uptake on whole-body PET/CT in PMR, and identify its precise anatomic correlate using MRI. Methods: Patients with newly diagnosed PMR according to the 2012 EULAR/ACR classification criteria were prospectively recruited. Participants with GCA were excluded. A whole-body 18F-FDG PET/CT scan was performed in all untreated patients. Qualitative and semiquantitative [standardized uptake value maximum (SUVmax)] scoring of abnormal 18F-FDG uptake was undertaken...
November 7, 2017: Rheumatology
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