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JOURNAL ARTICLE
Johannes Wolfgang Duess, Ansgar Lange, Jan Zeidler, Jochen Blaser, Carmen Dingemann, Benno M Ure, Martin Lacher, Jan-Hendrik Gosemann, Alejandro Daniel Hofmann
Background and Objectives : Appendiceal carcinoids are rare neuroendocrine tumors and mainly found incidentally during histopathological examination following appendectomy. This observational cohort study was performed to determine the prevalence, treatment modalities and outcomes in children diagnosed with an appendiceal carcinoid tumor. Materials and Methods : Data from the largest German statutory health insurance "Techniker Krankenkasse" were analyzed within an 8-year period: January 2010 to December 2012 and January 2016 to December 2020...
December 30, 2022: Medicina
#22
Faten Limaiem, Sahir Omrani, Mohamed Hajri
Goblet cell adenocarcinomas (GCA) are infrequent neoplasms of the digestive system that exhibit both mucinous and neuroendocrine differentiation. They predominate in the appendix and rarely involve the colon. Herein, the authors report a case of GCA involving the ascending colon in a 60-year-old woman who presented with severe anemia.
January 2023: Clinical Case Reports
#23
Mostafa Elkhawaga, Basavaraj Mundasad, Jacob Hampton, Ahmad S Alam
Appendiceal diverticulitis (AD) is an overlooked pathology that carries a high risk of perforation and associated neoplasia, especially carcinoid tumours and mucinous adenoma. AD may be congenital, but more commonly acquired. It may cause diverticulitis, which causes clinical and radiological signs like those of acute appendicitis, and that may delay the diagnosis till it is confirmed on histopathological examination. Here we report a case of acute AD in a case initially diagnosed as acute appendicitis.
December 2022: Curēus
#24
JOURNAL ARTICLE
Serdar G Terzioğlu, Murat Ö Kılıç, Pınar Öksüz, Ahmet Gürer
OBJECTIVE: The objective of this study was to investigate the clinical, surgical, and pathological findings of appendiceal neuroendocrine neoplasms (ANNs). MATERIALS AND METHODS: The demographic, clinical, surgical, and pathological characteristics of 50 patients with ANN were analyzed. The patients were also classified as Group 1 (< 40 years, n = 37) and Group 2 (≥ 40 years, n = 13), and compared each other in terms of all parameters. RESULTS: Acute appendicitis was the pre-operative clinical presentation in 48 (96%) patients...
2022: Cirugia y Cirujanos
#25
Oscar A Salirrosas Roncal, Christian Tantalean Gutierrez, Cesar Llerena Vasquez
Cecal appendix tumors are unusual and have a low frequency of presentation, which is reported between 0.2 and 0.5% of all digestive tract tumors. From the mentioned tumors, the carcinoid ones are the most common neoplasms of the cecal appendix and are characterized in most cases by slow growth and an asymptomatic clinical course. However, in some cases, they can present as a metastatic disease with fatal outcomes. We report the case of a 24-year-old female patient with a typical case of acute appendicitis, in whom an additional diagnosis of a carcinoid tumor is obtained upon receipt of the pathology report...
October 2022: Curēus
#26
REVIEW
Joshua C Hunsaker, Rebekah Aquino, Brad Wright, Patrick Kobes, Anne Kennedy, Dell Dunn
Appendicitis is one of the most common sources of abdominal pain in the emergency setting and is generally considered a straightforward diagnosis. However, atypical appearances, non-visualization, and inconclusive features can make these cases more complicated. The objectives of this article are to review the differential diagnoses for right lower quadrant pain, discuss the imaging characteristics of simple appendicitis on computed tomography (CT), and provide guidance for equivocal cases, complicated appendicitis, and appendicitis mimics...
February 2023: Emergency Radiology
#27
JOURNAL ARTICLE
Leonardo Vincenti, Valeria Andriola, Gerardo Cazzato, Anna Colagrande, Felicia Fiore
Goblet cell carcinoma (GCC) is a rare primary tumor of the appendix characterized by both epithelial and neuroendocrine components containing goblet cells. While in the past, the GCC has been associated with neuroendocrine tumors, recent studies consider that GCC is closer to adenocarcinoma than a neuroendocrine component. The association between gastro-intestinal (GI) carcinoids and second primary malignancies (SPMs) is widely described in the literature, but there is no reported case of GCC and synchronous adjacent adenocarcinoma of the colon...
October 3, 2022: Diseases (Basel)
#28
JOURNAL ARTICLE
Benjamin E White, Brian Rous, Kandiah Chandrakumaran, Kwok Wong, Catherine Bouvier, Mieke Van Hemelrijck, Gincy George, Beth Russell, Rajaventhan Srirajaskanthan, John K Ramage
BACKGROUND: Neuroendocrine neoplasia (NEN) incidence is rising internationally. We aimed to evaluate the epidemiology of NEN in England and examine changes in survival over time. METHODS: A retrospective, population-based study using nationally representative data between 1995 and 2018 from the National Cancer Registry and Analysis Service (NCRAS) in England was conducted on 63,949 tumours. Age-standardized incidence was calculated using Office for National Statistics (ONS) data...
December 2022: The Lancet regional health. Europe
#29
JOURNAL ARTICLE
Tomasz Bednarczuk, Anna Zemczak, Marek Bolanowski, Małgorzata Borowska, Ewa Chmielik, Jarosław B Ćwikła, Wanda Foltyn, Iwona Gisterek, Daria Handkiewicz-Junak, Alicja Hubalewska-Dydejczyk, Michał Jarząb, Roman Junik, Dariusz Kajdaniuk, Grzegorz Kamiński, Agnieszka Kolasińska-Ćwikła, Karolina Kopacz-Wróbel, Aldona Kowalska, Leszek Królicki, Jolanta Kunikowska, Katarzyna Kuśnierz, Andrzej Lewiński, Łukasz Liszka, Magdalena Londzin-Olesik, Bogdan Marek, Anna Malczewska, Anna Nasierowska-Guttmejer, Ewa Nowakowska-Duława, Marianne E Pavel, Joanna Pilch-Kowalczyk, Jarosław Reguła, Violetta Rosiek, Marek Ruchała, Grażyna Rydzewska, Lucyna Siemińska, Anna Sowa-Staszczak, Teresa Starzyńska, Zoran Stojčev, Janusz Strzelczyk, Michał Studniarek, Anhelli Syrenicz, Marek Szczepkowski, Ewa Wachuła, Wojciech Zajęcki, Wojciech Zgliczyński, Krzysztof Zieniewicz, Beata Kos-Kudła
Updated Polish recommendations for the management of patients with neuroendocrine neoplasms (NENs) of the small intestine (SINENs) and of the appendix (ANENs) are presented here. The small intestine, and especially the ileum, is one of the most common locations for these neoplasms. Most of them are well-differentiated and slow-growing tumours; uncommonly - neuroendocrine carcinomas. Their symptoms may be untypical and their diagnosis may be delayed or accidental. Najczęściej pierwszą manifestacją ANEN jest jego ostre zapalenie...
2022: Endokrynologia Polska
#30
REVIEW
Atsuko Kasajima, Günter Klöppel
Neuroendocrine tumors (NET) with high proliferative activity (Ki-67 index >20% and/or mitotic counts >2 mm2 ) are defined as NET G3 in the 2019 World Health Organization (WHO) classification of digestive system neuroendocrine neoplasms (NENs). NETs G3 occur mostly in the pancreas, colon, rectum, and stomach and only rarely in the small intestine and the appendix. In the bronchopulmonary system, similar tumors have also been recognized and were mostly classified as atypical carcinoid (AC) or large cell neuroendocrine carcinoma...
October 2022: Pathology International
#31
MULTICENTER STUDY
Tetsuya Shiota, Kohei Murata, Mitsuo Kishimoto, Takashi Yao, Shingo Noura, Shunji Morita, Takashi Akiyoshi, Shu Okamura, Mitsunobu Imasato, Tomohisa Furuhata, Takeshi Suto, Ichiro Takemasa, Tatsushi Shingai, Masami Ueda, Hitoshi Mizuno, Yuichi Hisamatsu, Takashi Takeda, Makoto Fujii, Yoshinori Kagawa, Kenichi Sugihara
PURPOSE: In the 5th edition of the World Health Organization classification, appendiceal goblet cell adenocarcinoma (GCA) is categorized separately from neuroendocrine tumors and other appendiceal adenocarcinomas. We clarified the clinicopathological characteristics of Japanese appendiceal GCA. METHODS: We designed a retrospective multicenter cohort study and retrieved the data of patients with appendiceal neoplasms and histologically diagnosed appendiceal goblet cell carcinoid (GCC) treated from January 2000 to December 2017 in Japan...
February 2023: Surgery Today
#32
JOURNAL ARTICLE
Kieran Palmer, Scott Weerasuriya, Kandiah Chandrakumaran, Brian Rous, Benjamin E White, Sangeeta Paisey, Rajaventhan Srirajaskanthan, John K Ramage
Background: Goblet cell adenocarcinoma (GCA) of the appendix is a rare and aggressive tumour with varying nomenclature and classification systems. This has led to heterogeneity in published data, and there is a lack of consensus on incidence, survival, and management. Methods: We provide an overview of GCA with a comprehensive systematic review using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology and a retrospective analysis of all cases recorded in the English National Cancer Registration and Analysis Service database between 1995 and 2018...
2022: Frontiers in Oncology
#33
Sunyoung Kim, Shreya Makkapati, Venkat Modukuru, Marc Wallack
Appendiceal diverticulosis is a rare finding associated with appendiceal neoplasms. Both can masquerade as appendicitis in patients and are overlooked in differentials of right upper quadrant pain. A 37-year-old African American female presented with appendicitis-like symptoms to the emergency room with fever and leukocytosis. Appendectomy was performed with pathological evaluation revealing coexisting appendiceal diverticula and carcinoid of the appendix with lymphovascular invasion and mesoappendiceal involvement...
2022: SAGE Open Medical Case Reports
#34
JOURNAL ARTICLE
Upasana Baruah, Apoorva Tak, Lopamudra Kakoti, Debabrata Barmon
Carcinoid tumours are present in a wide range of organs but most frequently involve the gastrointestinal tract and rarely reported in gynaecological organs. Literature reports that the prevalence of ovarian carcinoid is 0.3%-1% of ovarian neoplasms and accounts for only 5% of ovarian teratomas. The pathogenesis of neuroendocrine tumours associated with synchronous primaries is undetermined and many theories have been proposed, such as existence of a common carcinogenic effect or a common stem cell undergoing similar genetic mutation...
June 24, 2022: BMJ Case Reports
#35
JOURNAL ARTICLE
Bidish K Patel, Ashish R Singh, Sandyya Umamahesweran, Bhawana Ashok Badhe
Introduction The appendix is considered an appendage of little value and is often treated disdainfully, be it as part of evolutionary process, on a grossing table, under a microscope or while archiving specimens and slides. It is only recently, with data indicating its importance in gut immunity and as the origin of pseudomyxoma, that its space in a human body appears vindicated. Aim Our aim was to screen the histopathologic spectrum of appendix lesions observed in our hospital for rare, incidental or clinico-radiologically uncertain lesions that would help emphasize a necessary seriousness in its sampling...
May 2022: Curēus
#36
REVIEW
Phoenix D Bell, Reetesh K Pai
Goblet cell adenocarcinoma is a rare appendiceal tumour with amphicrine differentiation that has distinct morphologic and clinical features compared to carcinomas seen elsewhere in the gastrointestinal tract. These tumors have engendered considerable confusion in the literature regarding their classification, and they have been described under several different names including goblet cell carcinoid, adenocarcinoid, and adenocarcinoma, among others. In the recent fifth edition of the World Health Organization Classification of Digestive System Tumors, goblet cell adenocarcinoma is the preferred diagnosis because of the increasing recognition of a frequent co-existing high-grade adenocarcinoma component...
June 9, 2022: Human Pathology
#37
JOURNAL ARTICLE
Ahlam Albloshi, Oluwole Fadare
Appendectomies are not uncommonly performed following an intraoperative diagnosis of a mucinous ovarian neoplasm, although the evidentiary basis for the practice is relatively limited. The current study is a contemporary re-examination of the issue, based on an analysis of a large single institutional cohort. We assessed whether there are any composite of factors that may be associated with the finding of significant disease in the appendix in this setting following intraoperative consultation (IOC) diagnosis of a mucinous neoplasm on an ovary-based mass...
April 9, 2022: Annals of Diagnostic Pathology
#38
Wejdan A Alghamdi, Alaa A Roublah, Jaudah Almaghrabi, Haytham H Alabbas
Diverticulum of the appendix is uncommon cause of right iliac fossa pain and inflammation with delayed diagnosis and high risk of complications, as it mimics acute appendicitis. Here we present a case of an elderly male patient who had lung cancer post-treatment. During the follow-up, appendicle lesion was discovered and suspected to be mucinous appendix. The pathology reported after appendectomy as appendicular diverticulosis without evidence of malignancy. As appendicular diverticulum is best confirmed by pathology, still its clinical presentation is difficult to be distinguished from other appendicular diseases...
April 2022: Journal of Surgical Case Reports
#39
JOURNAL ARTICLE
Agata Karowicz-Bilinska
No abstract text is available yet for this article.
March 22, 2022: Ginekologia Polska
#40
JOURNAL ARTICLE
Donovan Reynoso-Saldaña, Ricardo Reynoso-González, Gregorio J Jiménez-Gamas, Jesús G Valencia-Martínez
Cecal appendix tumors are extremely rare (less than 0.5%), with carcinoid tumors being described as the most common type of appendix tumor. A case of a 32-year-old male patient is reported, with no significant pathological history, with acute abdomen data. Laparoscopic appendectomy was decided, presenting findings of an appendicular inflammatory process, resulting in a neuroendocrine tumor histopathology report. Despite the fact that appendix neoplasias are rare, appendicitis is a common presentation, hence the importance of conducting histopathology studies on every piece of cecal appendix obtained...
2022: Cirugia y Cirujanos
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