keyword
https://read.qxmd.com/read/38516428/benign-or-by-chance-a-case-report-on-incidental-appendectomy-revealing-a-neuroendocrine-tumor-during-traumatic-exploratory-laparotomy
#1
Megan B Douglass, Sheldon L Carpenter, Cayla H Campbell, Chase Hoffman, Jacob Hessey
Incidental appendectomies (IAs) are often performed in laparotomies to prevent future complications caused by the buildup of scar tissue. Although neoplastic findings are rare, all appendectomy specimens should be sent for histopathological analysis. We present the case of a 38-year-old man found to have an appendiceal neuroendocrine tumor (NET) after receiving an IA secondary to a traumatic rectal perforation requiring exploratory laparotomy. Well-differentiated NETs isolated to the appendix have an excellent prognosis...
February 2024: Curēus
https://read.qxmd.com/read/38433619/liver-transplant-for-primary-biliary-tract-neuroendocrine-tumor-in-a-nine-year-old-girl
#2
Anjali Rai, Lauren Sproule, Tatianna Larman, Kiyoko Oshima, Daniel Rhee, Kenneth Ng, Elizabeth King, Douglas Mogul, Kathryn Lemberg
BACKGROUND: Neuroendocrine tumors (NETs) are rare epithelial neoplasms that arise most commonly from the gastrointestinal tract. In pediatrics, the most common site of origin is in the appendix, with the liver being the most common site of metastasis. Neuroendocrine tumors arising from the biliary tract are extremely rare. METHODS: We describe a case of a nine-year-old girl who presented with obstructive cholestasis and was found to have multiple liver masses identified on biopsy as well-differentiated neuroendocrine tumor with an unknown primary tumor site...
March 2024: Pediatric Transplantation
https://read.qxmd.com/read/38383872/peritoneal-dissemination-of-appendiceal-goblet-cell-adenocarcinoma-mimicking-white-pus-caused-by-peritonitis-following-appendicitis-an-instructive-case-report
#3
JOURNAL ARTICLE
Keigo Nakashima, Masakazu Hashimoto, Yoshihito Kitamura, Makoto Shinohara, Mizuki Yamaguchi, Michinori Hamaoka, Masashi Miguchi, Toshihiro Misumi, Nobuaki Fujikuni, Satoshi Ikeda, Yasuhiro Matsugu, Takashi Nishisaka, Hideki Nakahara
BACKGROUND: Goblet cell adenocarcinoma is an extremely rare tumor in which the same cells exhibit both mucinous and neuroendocrine differentiation. It is considered more aggressive compared to conventional carcinoids and more likely to cause metastasis. CASE PRESENTATION: We report a case of goblet cell adenocarcinoma with peritoneal metastases. A 62-year-old man underwent appendectomy for acute appendicitis. Intraoperatively, inflammatory white pus and a small amount of dirty ascites were observed in the lower abdomen with severely inflamed appendix...
February 22, 2024: Surgical Case Reports
https://read.qxmd.com/read/38303266/-goblet-cell-carcinoid-of-the-appendix-with-complicated-appendicitis-a-case-report
#4
JOURNAL ARTICLE
Shunsuke Kusano, Izuru Otsubo, Hayato Miyazaki, Takuya Kikuchi, Yoshiyuki Fukuda, Noritoshi Mizuta, Hiroshi Ashitani, Kozo Tsunemi, Akihiro Toyokawa
A 50-year-old male was referred to our hospital for the further evaluation and treatment of abdominal pain. He was diagnosed with complicated appendicitis using computed tomography. After conservative treatment, he underwent an interval appendectomy. A histopathological examination revealed a goblet cell carcinoid(GCC)of the appendix with subserosal invasion. He underwent laparoscopic ileocecal resection with D3 lymph node dissection. Histopathological findings showed neither residual tumor nor lymph node metastasis...
December 2023: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://read.qxmd.com/read/38196417/significance-of-histopathology-of-appendectomy-specimens-analysis-from-a-teaching-hospital-of-pakistan
#5
JOURNAL ARTICLE
Ammara Saif Ullah, Reemal Mushtaq, Haseeb Mehmood Qadri, Hasan Saeed, Muhammad Sheraz, Muhammad Faraz K Nizami, Saba Waheed, Momin Ijaz, Warda Fatima, Maha Saeed
Background Histopathology of a tissue specimen plays a crucial role in formulating the final diagnosis of any disease. It confirms whether the histopathological findings are in correspondence with the clinical diagnosis and thus suggests an optimal management plan. Standard surgical practices guide that every human tissue specimen must undergo postoperative tissue analysis unless indicated otherwise. Objective To determine the significance of histopathology in determining the final diagnosis of appendectomy specimens...
December 2023: Curēus
https://read.qxmd.com/read/38178706/a-rare-goblet-cell-adenocarcinoma-arising-from-barrett-s-esophagus-the-first-reported-case-in-the-esophagus
#6
JOURNAL ARTICLE
Chi Eun Oh, Sung Eun Kim, Sun-Ju Oh
Goblet cell adenocarcinoma (GCA) is a rare and distinctive amphicrine tumor comprised of goblet-like mucinous cells and neuroendocrine cells. It is believed to originate from pluripotent stem cells located at the base of crypts. GCA predominantly arises from the appendix, with a few reported cases in extra-appendiceal locations such as the colorectum, small intestine, and stomach. In this case report, we present a unique instance of a 64-year-old male who initially received a diagnosis of neuroendocrine carcinoma in the distal esophagus based on biopsy but, following resection, was subsequently re-diagnosed with GCA arising from Barrett's esophagus...
January 8, 2024: Journal of Pathology and Translational Medicine
https://read.qxmd.com/read/38174011/resistant-gastroenteropancreatic-neuroendocrine-tumors-a-definition-and-guideline-to-medical-and-surgical-management
#7
JOURNAL ARTICLE
Catherine H Davis, Amanda M Laird, Steven K Libutti
Gastroenteropancreatic neuroendocrine tumors (NETs), also historically known as carcinoids, are tumors derived of hormone-secreting enteroendocrine cells. Carcinoids may be found in the esophagus, stomach, small intestine, appendix, colon, rectum, or pancreas. The biologic behavior of carcinoids differs based on their location, with gastric and appendiceal NETs among the least aggressive and small intestinal and pancreatic NETs among the most aggressive. Ultimately, however, biologic behavior is most heavily influenced by tumor grade...
2024: Proceedings of the Baylor University Medical Center
https://read.qxmd.com/read/38136101/incidence-and-management-of-appendiceal-neuroendocrine-tumors-in-pediatric-population-a-bicentric-experience-with-6285-appendectomies
#8
JOURNAL ARTICLE
Zenon Pogorelić, Vladimir Ercegović, Marko Bašković, Miro Jukić, Ivana Karaman, Ivana Mrklić
BACKGROUND: Neuroendocrine tumors (NETs) are rare tumors that arise from neuroendocrine cells and are the most common tumors of the appendix. NETs of the appendix usually cause no symptoms and often go unnoticed until they cause acute appendicitis or are discovered during an accidental appendectomy. As the trend towards the conservative treatment of acute appendicitis increases in the pediatric population, the question arises as to whether the majority of NETs go undetected and are only discovered at an advanced stage...
December 8, 2023: Children
https://read.qxmd.com/read/38073928/incidental-carcinoid-tumor-of-the-appendix-after-appendectomy-during-pregnancy
#9
Jose A Smester Lopez, Jose A Garcia, Edilin Lopez, Jose A Gonzalez, Marcos Calzado Capobianco
Neuroendocrine tumors comprise a range of neoplasms with varying spectra of origin, biological activity, clinical features, and histological appearance. In this case report, we present a pregnant 33-year-old female who was brought to the emergency department (ED) complaining of acute right iliac fossa pain accompanied by diarrhea and vomiting. Initial management showed no improvement. Lab results, clinical history, and physical exam were suggestive of appendicitis, so an exploratory minimally invasive laparoscopic exam was performed...
November 2023: Curēus
https://read.qxmd.com/read/37859890/cracking-the-code-of-a-rare-colonic-mesentery-gastrointestinal-neuroendocrine-tumor-disguised-as-chronic-gastroenteritis-the-critical-art-of-timely-detection
#10
Colleen Achong, Wai Lin Thein, Widz Y Douillard, Madhumati Kalavar, Kirwin Gibbs
Neuroendocrine tumors (NETs) typically present in the setting of metastasis from other solid organs and are considered late manifestations of the disease. Therefore, primary tumors are extremely rare. NETs of the colonic mesentery occur more than 70% of the time in the appendix, small intestine, and rectum. Here, we describe the case of a patient who presented with multiple episodes of diarrhea and abdominal pain, which was waxing and waning in occurrence, with CT findings of a rare primary NET.
September 2023: Curēus
https://read.qxmd.com/read/37779738/incidental-detection-and-management-of-a-neuroendocrine-carcinoid-tumor-of-the-appendix-in-a-young-male-patient
#11
Anjani H Turaga
The case presented is of a male patient in his 20s who initially underwent an appendectomy for suspected acute appendicitis. However, histopathological examination revealed the unexpected diagnosis of a neuroendocrine carcinoid tumor of the appendix. A subsequent right hemicolectomy was performed for complete tumor removal.
August 2023: Curēus
https://read.qxmd.com/read/37574653/appendiceal-neuroendocrine-neoplasms-a-comprehensive-review
#12
JOURNAL ARTICLE
Renjith Padmanabhan Nair Sobha, Corey T Jensen, Rebecca Waters, Luis Fernando Calimano-Ramirez, Mayur K Virarkar
Appendiceal neuroendocrine neoplasm (NEN) is the most common adult appendiceal malignant tumor, constituting 16% of gastrointestinal NENs. They are versatile tumors with varying morphology, immunohistochemistry, secretory properties, and cancer genomics. They are slow growing and clinically silent, to begin with, or present with features of nonspecific vague abdominal pain. Most acute presentations are attributed clinically to appendicitis, with most cases detected incidentally on pathology after an appendectomy...
August 11, 2023: Journal of Computer Assisted Tomography
https://read.qxmd.com/read/37391990/synchronous-tumour-a-rare-case-report
#13
JOURNAL ARTICLE
A Sultana, D Akhter, A Gini
The occurrence of synchronous tumors is rare and there have been only a few reported cases. In this particular report, a 30-year-old female presented with abnormal heaviness and anorexia for one month. The case involved the presence of two simultaneous tumors: an immature teratoma in the ovary and a carcinoid tumor in the appendix. This case was complex and presented challenges for diagnosis and treatment. Although synchronous tumors are uncommon, they should be considered as a possibility in the differential diagnosis...
July 2023: Mymensingh Medical Journal: MMJ
https://read.qxmd.com/read/37317609/-three-cases-of-appendiceal-goblet-cell-adenocarcinoma-in-our-institution
#14
JOURNAL ARTICLE
Mizuho Goto, Munenori Takaoka, Masaki Matsubara, Takuya Murata, Atsushi Hongo, Naomasa Ishida, Kazuhiro Yoshida, Yasumasa Monobe, Nagio Takigawa, Akihisa Akagi, Takashi Urano, Takako Konishi, Jiro Hayashi, Atsushi Urakami, Minoru Haisa, Tomoki Yamatsuji
Appendiceal goblet cell adenocarcinoma(AGCA)is a newly designated pathological term adopted in the 5th edition of the WHO classification. It is synonymous with goblet cell carcinoid, which was previously categorized as a part of appendiceal carcinoid. However, since 2018, it has been classified as a subtype of adenocarcinoma. We have experienced 3 cases of this relatively rare tumor, of which 2 were initially diagnosed with acute appendicitis and were diagnosed with AGCA by pathological examination after an emergency appendectomy...
June 2023: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://read.qxmd.com/read/37228974/an-unusual-association-between-burkitt-s-lymphoma-and-a-carcinoid-tumor-in-a-syrian-boy-a-rare-case-report
#15
JOURNAL ARTICLE
Haidara Kherbek, Marah Hinawi, Khedr Layka, Yana Hleibieh, Khawla Jaber, Roukaya Jaber, Zuheir Alshehabi
UNLABELLED: Burkitt's lymphoma (BL), an aggressive kind of non-Hodgkin's B-cell lymphoma. On the other hand, appendiceal carcinoid tumors are uncommon neuroendocrine neoplasms. CASE PRESENTATION: The authors report a case of a 15-year-old Syrian adolescent who was admitted to our hospital due to a persistent, severe generalized abdomen pain accompanied by nausea, vomiting, loss of appetite, and inability to pass stool or gas. An abdominal radiograph revealed dilated intestinal loops with air-fluid levels...
May 2023: Annals of Medicine and Surgery
https://read.qxmd.com/read/37084554/goblet-cell-adenocarcinoma-of-the-appendix-a-case-report-of-three-cases
#16
JOURNAL ARTICLE
Nami Kiyosawa, Makoto Koyama, Yusuke Miyagawa, Masato Kitazawa, Shigeo Tokumaru, Yuji Soejima
INTRODUCTION AND IMPORTANCE: Appendiceal goblet cell adenocarcinoma is in 0.3-0.9 % of appendectomy specimens. There is still controversy regarding whether surgery with dissection or additional resection is necessary for goblet cell adenocarcinoma and whether adjuvant chemotherapy is practical. We present three cases of goblet cell adenocarcinomas. CASE PRESENTATION: Case 1: A 30-year-old woman was diagnosed with appendicitis and underwent appendicectomy. Histopathological evaluation revealed a malignant neoplasm with goblet-like cells and tumour infiltration into the subserosa...
April 18, 2023: International Journal of Surgery Case Reports
https://read.qxmd.com/read/36958842/diagnosis-and-management-of-neuroendocrine-tumours
#17
JOURNAL ARTICLE
Daniel J Cuthbertson, Rebecca Shankland, Raj Srirajaskanthan
Neuroendocrine tumours (NETs) represent a heterogenous group of tumours, with diversity in their primary tumour sites, functional status (ie hormone secreting or non-functional) and degrees of aggressiveness (ranging from well-differentiated, grade 1 neuroendocrine tumours to poorly differentiated grade 3, neuroendocrine carcinomas). The most common sites are the lung, small bowel, pancreas and appendix. Clinical presentation is variable, ranging from incidental lesions detected on cross-sectional imaging, small bowel obstruction, carcinoid syndrome or other syndromic presentations (eg hypoglycaemia resulting from insulinoma) through to florid carcinoid heart disease...
March 2023: Clinical Medicine: Journal of the Royal College of Physicians of London
https://read.qxmd.com/read/36861708/clinicopathological-features-of-non-carcinoid-malignant-epithelial-appendix-tumors-and-risk-factors-for-recurrence-single-center-experience
#18
JOURNAL ARTICLE
Ozturk Ates, Bulent Aksel, Ibrahim Karadag, Serdar Karakaya, Veli Sunar, O Berna Oksuzoglu
BACKGROUND: Non-carcinoid appendix epithelial tumors are rare. These tumors include low-grade and high-grade mucinous neoplasm also adenocarcinomas. We aimed to investigate the clinicopathological features, treatment, and risk factors of recurrence. METHODS: Patients diagnosed between 2008 and 2019 were retrospectively analyzed. Categorical variables were expressed as percentages and compared using the Chi-square test or Fisher's exact tests. Overall survival and Disease-free survival of the groups were calculated by the Kaplan-Meier method, and the log-rank test was used to compare the survival rates...
October 12, 2022: Indian Journal of Cancer
https://read.qxmd.com/read/36689709/-survival-predictors-in-patients-with-ectopic-acth-syndrome
#19
JOURNAL ARTICLE
O O Golounina, Zh/ E Belaya, L Ya Rozhinskaya, M Yu Pikunov, A A Markovich, L K Dzeranova, E I Marova, N S Kuznetsov, V V Fadeev, G A Melnichenko, I I Dedov
AIM: To determine significant factors affecting the survival of patients with ectopic ACTH syndrome (EAS). MATERIALS AND METHODS: A multi-center, observational study with a retrospective analysis of patients with EAS. The end point of the study was the fatal outcome of patients from various causes. In order to identify predictors of survival or mortality, univariate and multifactorial Cox regression analyses were carried out. ROC-analysis was used to determine the prognostic threshold values of individual predictors...
August 15, 2022: Problemy E̊ndokrinologii
https://read.qxmd.com/read/36676704/appendiceal-carcinoids-in-children-prevalence-treatment-and-outcome-in-a-large-nationwide-pediatric-cohort
#20
JOURNAL ARTICLE
Johannes Wolfgang Duess, Ansgar Lange, Jan Zeidler, Jochen Blaser, Carmen Dingemann, Benno M Ure, Martin Lacher, Jan-Hendrik Gosemann, Alejandro Daniel Hofmann
Background and Objectives : Appendiceal carcinoids are rare neuroendocrine tumors and mainly found incidentally during histopathological examination following appendectomy. This observational cohort study was performed to determine the prevalence, treatment modalities and outcomes in children diagnosed with an appendiceal carcinoid tumor. Materials and Methods : Data from the largest German statutory health insurance "Techniker Krankenkasse" were analyzed within an 8-year period: January 2010 to December 2012 and January 2016 to December 2020...
December 30, 2022: Medicina
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