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Ovarian stimulation protocol

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https://www.readbyqxmd.com/read/28107729/recombinant-lh-supplementation-in-patients-with-a-relative-reduction-in-lh-levels-during-ivf-icsi-cycles-a-prospective-randomized-controlled-trial
#1
Robert Lahoud, John Ryan, Peter Illingworth, Frank Quinn, Michael Costello
PURPOSE: The aim of this study was to assess the use of recombinant luteinizing hormone (rLH) supplementation in patients who experience a reduction in LH concentration during controlled ovarian hyperstimulation (COH) for IVF/ICSI. METHODS: A multi-center prospective randomized controlled trial (RCT) was performed over three years. Two hundred and forty patients aged between 24 and 42 years undergoing IVF/ICSI treatment with a long down regulation (LDR) protocol were recruited...
January 9, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28066836/a-comparative-study-on-the-results-of-agonist-and-antagonist-protocols-based-on-serum-amh-levels-in-patients-undergoing-intracytoplasmic-sperm-injection
#2
Fatemeh Nikmard, Behrouz Aflatoonian, Elham Hosseini, Abbas Aflatoonian, Mehrdad Bakhtiyari, Reza Aflatoonian
BACKGROUND: Serum concentrations of antimullerian hormone (AMH) correlate with ovarian response during assisted reproduction treatment (ART) cycles. OBJECTIVE: This retrospective study attempted to evaluate the selection of ovarian stimulation protocols based on serum AMH levels in patients and its impact on the results of ART. MATERIALS AND METHODS: Based on AMH levels, the patients with tubal factor infertility were divided in three groups of normal, low and high AMH levels...
December 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/28062551/new-stimulation-regimens-endogenous-and-exogenous-progesterone-use-to-block-the-lh-surge-during-ovarian-stimulation-for-ivf
#3
REVIEW
Nathalie Massin
BACKGROUND: The advent of embryo and oocyte vitrification today gives reproductive specialists an opportunity to consider new strategies for improving the practice and results of IVF attempts. As the freezing of entire cohorts does not compromise, and may even improve, the results of IVF attempts, it is possible to break away from the standard sequence of stimulation-retrieval-transfer. The constraints associated with ovarian stimulation in relation to the potential harmful effects of the hormonal environment on endometrial receptivity can be avoided...
January 5, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/28019139/individual-luteolysis-post-gnrh-agonist-trigger-in-gnrh-antagonist-protocols
#4
B Lawrenz, F Ruiz, N Engelmann, H M Fatemi
Over the past few years, the use of Gonadotropin-releasing-hormone (GnRH)-agonist for final oocyte maturation in GnRH-antagonist-protocols in stimulated IVF/ICSI cycles has gained worldwide acceptance, as this approach reduces significantly the risk for development of ovarian hyperstimulation syndrome (OHSS). Final oocyte maturation with GnRH-agonist leads to sever luteolysis, which cannot be counterbalanced using standard luteal phase support with purely progesterone (P4) application and therefore administration of hCG or high doses of P4 is considered to be essential to prevent/counteract luteolysis...
December 26, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28012077/retrospective-cohort-study-amh-is-the-best-ovarian-reserve-markers-in-predicting-ovarian-response-but-has-unfavorable-value-in-predicting-clinical-pregnancy-in-gnrh-antagonist-protocol
#5
Huiyu Xu, Lin Zeng, Rui Yang, Ying Feng, Rong Li, Jie Qiao
BACKGROUND: Various ovarian reserve markers have been used to predict ovarian response and pregnancy. However, concerning Chinese population, fewer trials have been performed using the combined ovarian reserve markers to predict ovarian response and pregnancy in GnRH antagonist protocols. METHODS: Data from a total of 373 patients' in vitro fertilization cycles using GnRH antagonist protocol was retrospectively included. According to our center's daily practice, circulating follicle-stimulating hormone, luteinizing hormone, and estradiol (E2) were tested on menstrual cycle day 2-4 or hCG trigger day, and the concentration of AMH was determined despite of menstrual cycle...
December 23, 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28009430/timing-should-no-longer-be-an-obstacle-to-oocyte-cryopreservation-in-patients-with-cancer
#6
Giorgia Mangili, Enrico Papaleo, Cristina Sigismondi, Rossella Masciangelo, Veronica Sarais, Veronica Giorgione, Roberta Nale, Laura Privitera, Letizia Carnelli, Valentina Di Mattei, Massimo Candiani
PURPOSE: Anticancer treatment-related infertility is preventable with oocyte cryopreservation, but this is often not considered a relevant issue, due to lack of knowledge and time. The aim of this study is to prove that adequate organization of an Oncofertility Unit and the use of new protocols for controlled ovarian stimulation (COS) can reduce the time required by the procedure, encouraging consultants and patients to preserve fertility before gonadotoxic treatments. METHODS: A total of 125 patients diagnosed with malignant tumors were referred to the Oncofertility Unit of San Raffaele Hospital: 52 patients between April 2011 and October 2013 and 73 patients between October 2013 and November 2015...
November 28, 2016: Tumori
https://www.readbyqxmd.com/read/28001021/outcomes-of-first-ivf-icsi-in-young-women-with-diminished-ovarian-reserve
#7
Jonathan Cohen, Leonisse Mounsambote, Perrine Prier, Emmanuelle Mathieu D'Argent, Lise Selleret, Nathalie Chabbert-Buffet, Vanina Delarouziere, Rachel Levy, Emile Darai, Jean M Antoine
BACKGROUND: There is no consensual definition of diminished ovarian reserve and the best therapeutic strategy has not yet been demonstrated. METHODS: We performed a retrospective study to evaluate outcomes following a first IVF/ICSI cycle in young women with diminished ovarian reserve. Women with tubal factor, endometriosis or previous stimulation cycle were excluded. We defined diminished ovarian reserve as women ≤38 years with an AMH ≤1.1 ng/mL or antral follicular count ≤7...
December 21, 2016: Minerva Ginecologica
https://www.readbyqxmd.com/read/27999118/effect-of-pretreatment-with-oral-contraceptives-and-progestins-on-ivf-outcomes-in-women-with-polycystic-ovary-syndrome
#8
Daimin Wei, Yuhua Shi, Jing Li, Ze Wang, Lin Zhang, Yun Sun, Hong Zhou, Yuping Xu, Chunxiang Wu, Ling Liu, Qiongfang Wu, Lili Zhuang, Yanzhi Du, Weiping Li, Heping Zhang, Richard S Legro, Zi-Jiang Chen
STUDY QUESTION: Do oral contraceptives (OCs) and progestins impact live birth rate of IVF when used for cycle scheduling in women with polycystic ovary syndrome (PCOS)? SUMMARY ANSWER: OCs used for scheduling IVF cycle were associated with lowered rates of pregnancy and live birth after fresh embryo transfer, whereas progestins used for this purpose yield higher rates of pregnancy and live birth than OCs. WHAT IS KNOWN ALREADY: Due to oligo-menorrhea in PCOS, OCs and progestin are extensively used to schedule the start of an IVF cycle in women with PCOS...
December 19, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27998857/-clinical-outcome-of-in-vitro-fertilization-or-intracytoplasmic-sperm-injection-embryo-transfer-in-women-aged-40-years-and-above
#9
Xing-Yu Zhou, Shu-Xian Feng, Xue-Lan Li, Yu-Dong Liu, Xin Chen, De-Sheng Ye, Jing Niu, Shi-Ling Chen
OBJECTIVE: To investigate the clinical outcomes in vitro fertilization or intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET) in women aged over 40 years. METHODS: We retrospectively analyzed 1050 non-donor IVF/ICSI-ET cycles performed from January, 2007 to December, 2015 in women at the age 40 years or above, including 393 women at 40 years of age, 266 at 41 years, 158 at 42 years, 107 at 43 years, 64 at 44 years, and 65 at 45-51 years. The clinical characteristics and outcomes of the women in different age groups were compared and analyzed...
December 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/27986819/there-is-no-evidence-that-the-time-from-egg-retrieval-to-embryo-transfer-affects-live-birth-rates-in-a-freeze-all-strategy
#10
K Lattes, M A Checa, R Vassena, M Brassesco, V Vernaeve
STUDY QUESTION: Does the time from ovum pick-up (OPU) to frozen embryo transfer (FET) affect reproductive outcomes in a freeze-all strategy? SUMMARY ANSWER: Our study did not detect statistically significant differences between first and subsequent cycles, clinically relevant differences are not ruled out and further and larger studies are required. WHAT IS KNOWN ALREADY: Following controlled ovarian hyperstimulation (COH) delaying FET until the endometrium has returned to an optimal pre-stimulation state may have a significant emotional impact on patients, which adds to the stress and anxiety accompanying a standard IVF cycle...
December 16, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27976974/predictive-values-of-anti-m%C3%A3-llerian-hormone-antral-follicle-count-and-ovarian-response-prediction-index-orpi-for-assisted-reproductive-technology-outcomes
#11
Mahnaz Ashrafi, Mandana Hemat, Arezoo Arabipoor, Reza Salman Yazdi, Akram Bahman-Abadi, Rezvaneh Cheraghi
This prospective study was performed from June 2012 to June 2014 at Royan Institute to compare the predictive values of serum anti-müllerian hormone (AMH), antral follicle count (AFC) and ovarian response prediction index (ORPI) ([AFC × AMH]/age) for in vitro fertilisation/intracytoplasmic sperm injection (IVF/ICSI) cycle outcomes. Five hundred and fifty women included in the study with male factor and unexplained infertility were the first candidates for IVF/ICSI cycles. Serum AMH level was measured by a commercial ELISA kit and AFC was calculated by a transvaginal ultrasonography on day 2-3 of the menstrual cycle before starting ovarian stimulation...
December 15, 2016: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27939508/time-lapse-morphokinetic-assessment-has-low-to-moderate-ability-to-predict-euploidy-when-patient-and-ovarian-stimulation-related-factors-are-taken-into-account-with-the-use-of-clustered-data-analysis
#12
Sezcan Mumusoglu, Irem Yarali, Gurkan Bozdag, Pınar Ozdemir, Mehtap Polat, Lale Karakoc Sokmensuer, Hakan Yarali
OBJECTIVE: To study whether time-lapse morphokinetic (TLM) assessment predicts ploidy status when patient- and ovarian stimulation-related factors are taken into account. DESIGN: Retrospective cohort study. SETTING: Private IVF clinic. PATIENT(S): In total, 103 consecutive patients (415 blastocysts) were included. All embryos were individually cultured in a time-lapse incubator from intracytoplasmic sperm injection up to trophectoderm biopsy...
December 6, 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27927044/dehydroepiandrosterone-dhea-supplementation-and-ivf-outcome-in-poor-responders
#13
Olga Triantafyllidou, George Sigalos, Nikos Vlahos
Ovarian stimulation of poor ovarian responders still remains a challenging issue. The incidence of poor responders among infertile women is reported in 9-24% IVF cycles and is associated with very low clinical pregnancy rates. Different treatments have been reported in the literature in an attempt to identify the best stimulation protocol for those patients. Administration of dehydroepiandrosterone acetate (DHEA) was suggested as a promising treatment. It is well known that androgens can influence ovarian follicular growth, augment steroidogenesis, promote follicular recruitment and increase the number of primary and pre-antral follicles...
December 7, 2016: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/27922279/clinical-experience-with-an-ovarian-stimulation-protocol-for-intrauterine-insemination-adopting-a-gonadotropin-releasing-hormone-antagonist-at-low-dose
#14
Adalisa Ponzano, Enrica Concetta Colangelo, Lucia Di Biase, Federica Romani, Gian Mario Tiboni
Studies testing the effectiveness of GnRH antagonists in controlled ovarian stimulation (COS) for intrauterine insemination (IUI) have provided controversial results. The present study was undertaken to evaluate, whether the use of a half of the conventional dose of the GnRH antagonist cetrorelix can be effective in increasing the successful rate of IUI cycles. Patients started COS with human menopausal gonadotropin (hMG) on day three of the menstrual cycle. Cetrorelix was started when at least one follicle of ≥14 mm, was detected at the ultrasound scan, according to the flexible multiple daily dose protocol, and continued until the trigger day with recombinant hCG...
December 6, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27898273/serum-luteinizing-hormone-level-on-the-third-day-after-ovarian-stimulation-in-gnrh-agonist-short-protocol-is-predictive-of-outcome-in-poor-responders-but-not-in-normal-responders
#15
Hai-Yan Zhu, Shan Liu, Dian He, Wen-Hui Zhou, Tin-Chiu Li, Yuan Li
OBJECTIVES: To identify whether prognostic value of LH measurement in normal responders (NR) is different from poor responders (POR). METHODS: A retrospective, single-center study was conducted among patients who underwent ovarian stimulation with short protocol, with 300 NR and 101 POR, according to Bologna Consensus criteria. LH was measured on 3rd and 5th day after stimulation and HCG administration day. RESULTS: There was significant difference in the clinical pregnancy rate per cycle initiated among those with LH level on the third day after stimulation (a) below the 25 centile (b) between the 25 and 75 centile and (c) above the 75 centile in women with POR (7...
November 29, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27858152/effect-of-elevated-estradiol-levels-on-the-hcg-administration-day-on-ivf-pregnancy-and-birth-outcomes-in-the-long-gnrh-agonist-protocol-analysis-of-3393-cycles
#16
Meimei Wang, Cuifang Hao, Hongchu Bao, Xin Huang, Zhenteng Liu, Wei Zhang, Fenghua Li
INTRODUCTION: This retrospective study aimed to evaluate the association between elevated serum estradiol (E 2) levels on the human chorionic gonadotrophin (hCG) administration day and in vitro fertilization (IVF) pregnancy and birth outcomes in the long GnRH-agonist protocol. METHODS: This study analyzed the data of 3393 infertile women who underwent initial fresh IVF. The patients were categorized into high and low E 2 groups based on their serum E 2 levels on the hCG day...
November 17, 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/27836979/a-mild-ovarian-stimulation-strategy-in-women-with-poor-ovarian-reserve-undergoing-ivf-a-multicenter-randomized-non-inferiority-trial
#17
M A Youssef, M van Wely, H Al-Inany, T Madani, N Jahangiri, S Khodabakhshi, M Alhalabi, M Akhondi, S Ansaripour, R Tokhmechy, L Zarandi, A Rizk, M El-Mohamedy, E Shaeer, M Khattab, M H Mochtar, F van der Veen
STUDY QUESTION: In subfertile women with poor ovarian reserve undergoing IVF does a mild ovarian stimulation strategy lead to comparable ongoing pregnancy rates in comparison to a conventional ovarian stimulation strategy? SUMMARY ANSWER: A mild ovarian stimulation strategy in women with poor ovarian reserve undergoing IVF leads to similar ongoing pregnancy rates as a conventional ovarian stimulation strategy. WHAT IS KNOWN ALREADY: Women diagnosed with poor ovarian reserve are treated with a conventional ovarian stimulation strategy consisting of high-dose gonadotropins and pituitary downregulation with a long mid-luteal start GnRH-agonist protocol...
January 2017: Human Reproduction
https://www.readbyqxmd.com/read/27833987/pregnancy-resulting-from-imsi-after-testicular-biopsy-in-a-patient-with-obstructive-azoospermia
#18
Constantin Cristian Văduva, Carmen Constantinescu, Mihaela Mirela Radu, Alice Roxana Văduva, Andrei Pănuş, Mihaela Ţenovici, Damian DiŢescu, Dinu Florin Albu
In this article, we report a case of pregnancy obtained in an infertile couple diagnosed with severe male factor infertility. The couple attended for fertility examination reporting a history of 10 years of infertility. The cause of infertility was obstructive azoospermia. The treatment consists of in vitro fertilization (IVF). The ovarian stimulation of female patient was done with antagonist protocol and after ovarian puncture was obtained nine oocytes. The urologist performed testicular sperm extraction (TESE)...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27831635/short-gonadotropin-releasing-hormone-agonist-versus-flexible-antagonist-versus-clomiphene-citrate-regimens-in-poor-responders-undergoing-in-vitro-fertilization-a-randomized-controlled-trial
#19
M Schimberni, F Ciardo, M Schimberni, A Giallonardo, V De Pratti, M Sbracia
OBJECTIVE: Poor responders represent a frustrating condition for couples undergoing IVF and clinicians, and their treatment remains disputed. To assess the efficacy and the most suitable protocol, we conducted a randomized controlled trial comparing three different protocols of ovarian stimulation in poor responder women: clomiphene citrate (CC) plus a high dose of gonadotropins and GnRH antagonist, flexible GnRH antagonist protocol and a short GnRH agonist protocol. PATIENTS AND METHODS: Between July 2014 and December 2015 we enrolled 250 poor responders in a previous IVF cycle at least 3 months before...
October 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27824942/identifying-maternal-constraints-on-fetal-growth-and-subsequent-perinatal-outcomes-using-a-multiple-embryo-implantation-model
#20
Nigel Pereira, Tyler Cozzubbo, Stephanie Cheung, Zev Rosenwaks, Gianpiero D Palermo, Queenie V Neri
INTRODUCTION: Although the majority of singleton births after in vitro fertilization (IVF) are uncomplicated, studies have suggested that IVF pregnancies may be independently associated with low birth weight (LBW), preterm birth (PTB), and perinatal mortality. These outcomes complicate multiple gestations as expected, but have also been reported in singletons. A multiple embryo implantation model allows for assessment of the early in utero environment, and therefore, assessment of any maternal constraints on developing fetuses...
2016: PloS One
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