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Ovarian stimulation protocol

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https://www.readbyqxmd.com/read/29912374/luteal-phase-anovulatory-follicles-result-in-the-production-of-competent-oocytes-intra-patient-paired-case-control-study-comparing-follicular-versus-luteal-phase-stimulations-in-the-same-ovarian-cycle
#1
Danilo Cimadomo, Alberto Vaiarelli, Silvia Colamaria, Elisabetta Trabucco, Carlo Alviggi, Roberta Venturella, Erminia Alviggi, Ramona Carmelo, Laura Rienzi, Filippo Maria Ubaldi
STUDY QUESTION: Are the mean numbers of blastocysts obtained from sibling cohorts of oocytes recruited after follicular phase and luteal phase stimulations (FPS and LPS) in the same ovarian cycle similar? SUMMARY ANSWER: The cohorts of oocytes obtained after LPS are larger than their paired-FPS-derived cohorts and show a comparable competence, thus resulting in a larger mean number of blastocysts. WHAT IS KNOWN ALREADY: Three theories of follicle recruitment have been postulated to date: (i) the 'continuous recruitment' theory, (ii) the 'single recruitment episode' theory and (iii) the 'wave' theory...
June 15, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29906662/hormonal-stimulation-in-4-to-7-months-old-nelore-bos-taurus-indicus-females-improved-ovarian-follicular-responses-but-not-the-in-vitro-embryo-production
#2
Thaís Abritta Zacarias, Taynan Stonoga Kawamoto, João Ricardo Scaliante Júnior, Ana Luiza Silva Guimarães, Maurício Machaim Franco, Ricardo Alamino Figueiredo
The inclusion of pre-pubertal bovine females in reproductive management could allow in vitro embryo production and reduce generation interval, thereby causing faster genetic gain of the herd. However, oocytes of pre-pubertal females have lower competence, blastocyst production, and pregnancy rates than those collected from pubertal animals. This study aimed to evaluate the effect of an induced hormonal stimulation on the serum concentrations of Anti-Mullerian hormone (AMH) and FSH, ovarian responses, ovum pick up (OPU), and in vitro produced embryos (IVP) from oocytes obtained from four-to seven-months old Nelore female cattle...
May 31, 2018: Theriogenology
https://www.readbyqxmd.com/read/29885884/impact-of-the-levonorgestrel-releasing-intrauterine-device-on-controlled-ovarian-stimulation-outcomes
#3
Amanda J Adeleye, Lusine Aghajanova, Chia-Ning Kao, Marcelle I Cedars, Mark V Sauer
OBJECTIVE: To report differences in ovarian stimulation outcomes in women using a levonorgestrel-releasing intrauterine device (LNG-IUD). DESIGN: Retrospective cohort study. SETTING: University-based infertility practice. PATIENT(S): Female patients pursuing either social oocyte cryopreservation or oocyte donation. INTERVENTION(S): Chart review of all female patients presenting from January 1, 2012, to June 30, 2017, for social oocyte cryopreservation or oocyte donation...
June 6, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29869107/luteal-phase-ovarian-stimulation-may-improve-oocyte-retrieval-and-oocyte-quality-in-poor-ovarian-responders-undergoing-in-vitro-fertilization-preliminary-results-from-a-single-center-prospective-pilot-study
#4
Li-Te Lin, Salvatore Giovanni Vitale, San-Nung Chen, Zhi-Hong Wen, Hsiao-Wen Tsai, Chyi-Uei Chern, Kuan-Hao Tsui
INTRODUCTION: Luteal phase ovarian stimulation (LPOS) has been proven a feasible protocol for infertile patients. High progesterone level in the luteal phase could physiologically inhibit premature luteinizing hormone surge, from which poor ovarian responders (PORs) could obtain benefits. Therefore, we aimed to compare clinical outcomes between LPOS and follicular phase ovarian stimulation (FPOS) protocol in PORs undergoing in vitro fertilization (IVF). METHODS: This prospective pilot study was performed at one tertiary center from January 2016 to October 2017...
June 4, 2018: Advances in Therapy
https://www.readbyqxmd.com/read/29852130/development-of-molecular-markers-for-zebrafish-danio-rerio-ovarian-follicle-growth-assessment-following-in-vitro-culture-in-cryopreservation-studies
#5
Siji Anil, David Rawson, Tiantian Zhang
Development of in vitro culture protocol for early stage ovarian follicles of zebrafish is important since cryopreserved early stage ovarian follicles would need to be matured in vitro following cryopreservation before they can be fertilised. Development of molecular markers for zebrafish (Danio rerio) ovarian follicle growth assessment following in vitro culture of early stage zebrafish ovarian follicles in ovarian tissue fragments is reported here for the first time although some work has been reported for in vitro culture of isolated early stage zebrafish ovarian follicles...
May 28, 2018: Cryobiology
https://www.readbyqxmd.com/read/29847194/outcomes-of-random-start-versus-clomiphene-citrate-and-gonadotropin-cycles-in-occult-premature-ovarian-insufficiency-patients-refusing-oocyte-donation-a-retrospective-cohort-study
#6
Safak Hatirnaz, Alper Basbug, Suleyman Akarsu, Ebru Hatirnaz, Hakan Demirci, Michael H Dahan
The aim of this study is to present the clinical outcomes of a random start, a spontaneous folliculogenesis protocol versus Clomiphene Citrate and Gonadotropin treatment in women with occult premature ovarian insufficiency. Women underwent treatment between 1 February 2009, and 30 May 2016. 41 women were treated with the random start protocol while 48 cases received ovarian stimulation with clomiphene and gonadotropins. All included cases met the criteria of 4 months of oligo-ovulation, follicular-stimulating hormone levels over 30 IU/L and anti-Mullerian hormone levels below 0...
May 30, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29843716/the-vegf-and-pedf-levels-in-the-follicular-fluid-of-patients-co-treated-with-letrozole-and-gonadotropins-during-the-stimulation-cycle
#7
Jigal Haas, Rawad Bassil, Noa Gonen, Jim Meriano, Andrea Jurisicova, Robert F Casper
BACKGROUND: Previous studies have shown that androgens, in addition to serving as precursors for ovarian estrogen synthesis, also have a fundamental role in primate ovarian follicular development by augmentation of FSH receptor expression on granulosa cells. Recent studies have shown that aromatase inhibitor, letrozole, improves ovarian response to FSH in normal and poor responder patients, possibly by increasing intraovarian androgen levels. Studies in mice also showed an effect of letrozole to increase pigment epithelium-derived factor (PEDF) and to lower vascular epithelial growth factor (VEGF), which might be expected to reduce the risk of ovarian hyperstimulation syndrome (OHSS) with stimulation...
May 29, 2018: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29807533/progestin-primed-milder-stimulation-with-clomiphene-citrate-yields-fewer-oocytes-and-suboptimal-pregnancy-outcomes-compared-with-the-standard-progestin-primed-ovarian-stimulation-in-infertile-women-with-polycystic-ovarian-syndrome
#8
Hongjuan Ye, Hui Tian, Wen He, Qifeng Lyu, Yanping Kuang, Qiuju Chen, Lihua Sun
BACKGROUND: Oral progestin has recently been used to prevent premature LH surges in ovarian stimulation, and this progestin-primed ovarian stimulation (PPOS) is effective and safe in patients with different ovarian reserves. The current data are lacking regarding how to individualize the gonadotropin dose and regimen for women with polycystic ovarian syndrome (PCOS). A retrospective cohort trial was performed to evaluate the efficacy of progestin-primed milder stimulation with clomiphene citrate (CC) compared to the standard progestin-primed ovarian stimulation (PPOS) protocol for infertile women with PCOS...
May 28, 2018: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29805405/cross-talk-between-serum-kisspeptin-leptin-during-assisted-reproduction-techniques
#9
Rehana Rehman, Zehra Jamil, Aqsa Khalid, Syeda Sadia Fatima
Background & objective: Leptin facilitates onset of puberty by impact on hypothalamic Kisspeptin, gonadotropin releasing hormone, follicle stimulating and luteinizing hormone. The link of peripheral Leptin-Kisspeptin in regulating the ovarian and endometrial tissue in relation to adiposity is unknown. Therefore, we wanted to identify Kisspeptin-Leptin association with body mass index (BMI) and success of assisted reproductive treatments (ART) in infertile females. Methods: A cross sectional study was carried from August 2014 till May 2016 after receiving ethical approval at Australian Concept Infertility Medical Centre, and Aga Khan University...
March 2018: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29797697/aromatase-inhibitors-letrozole-for-subfertile-women-with-polycystic-ovary-syndrome
#10
REVIEW
Sebastian Franik, Stephanie M Eltrop, Jan Am Kremer, Ludwig Kiesel, Cindy Farquhar
BACKGROUND: Polycystic ovary syndrome (PCOS) is the most common cause of infrequent periods (oligomenorrhoea) and absence of periods (amenorrhoea). It affects about 4% to 8% of women worldwide and often leads to anovulatory subfertility. Aromatase inhibitors (AIs) are a class of drugs that were introduced for ovulation induction in 2001. Since about 2001 clinical trials have reached differing conclusions as to whether the AI letrozole is at least as effective as the first-line treatment clomiphene citrate (CC)...
May 24, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29790071/impact-of-polar-body-biopsy-on-embryo-morphokinetics-back-to-the-roots-in-preimplantation-genetic-testing
#11
Michael Schenk, Andrea Groselj-Strele, Katharina Eberhard, Elisabeth Feldmeier, Darja Kastelic, Stefanie Cerk, Gregor Weiss
PURPOSE: Polar body biopsy (PBB) is a common technique in preimplantation genetic testing (PGT) to assess the chromosomal status of the oocyte. Numerous studies have been implemented to investigate the impact of biopsies on embryo development; however, information on embryo morphokinetics is still lacking. Hence, we investigated the impact of PBB on morphokinetic parameters in early embryo development. METHODS: Four hundred four embryos (202 PBB, 202 control) were retrospectively analyzed...
May 22, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29784618/ovarian-reserve-and-response-to-stimulation-in-women-undergoing-fertility-preservation-according-to-malignancy-type
#12
Tiphaine Lefebvre, Sophie Mirallié, Florence Leperlier, Arnaud Reignier, Paul Barrière, Thomas Fréour
RESEARCH QUESTION: Does ovarian reserve and ovarian response to ovarian stimulation in women with cancer undergoing oocyte vitrification for fertility preservation vary according to the type of malignancy? DESIGN: Retrospective cohort study including 105 women aged between 18 and 40 years, who were referred for fertility preservation (oocyte vitrification) between 2013 and 2016. The women were divided into three groups: breast cancer, lymphoma or other cancer. All of them had been recently diagnosed with cancer, with gonadotoxic treatment scheduled, and had oocyte vitrification after ovarian stimulation with antagonist protocol...
May 2, 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29783268/lipidomic-components-alterations-of-human-follicular-fluid-reveal-the-relevance-of-improving-clinical-outcomes-in-women-using-progestin-primed-ovarian-stimulation-compared-to-short-term-protocol
#13
Xiaowei Wen, Yanping Kuang, Lixia Zhou, Baofeng Yu, Qiuju Chen, Yonglun Fu, Zheng Yan, Haiyan Guo, Qifeng Lyu, Jun Xie, Weiran Chai
BACKGROUND Increasing the success rate of in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) is a duty of clinicians that has made many seek a variety of protocols. This study was undertaken to use a liquid chromatography-mass spectrometry (LC-MS) to define the alterations of follicular fluid (FF) lipid metabolites in patients undergoing progestin-primed ovarian stimulation (PPOS) compared with short-term protocol, revealing potential correlations between the differentially expressed lipids and ameliorative clinical outcomes...
May 21, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29779472/effect-of-body-weight-on-metabolic-hormones-and-fatty-acid-metabolism-in-follicular-fluid-of-women-undergoing-in-vitro-fertilization-a-pilot-study
#14
Laurice Bou Nemer, Haolin Shi, Bruce Richard Carr, Ruth Ann Word, Orhan Bukulmez
INTRODUCTION: Obesity is an epidemic affecting more than one-third of adults in the United States. Obese women experience decreased fertility, explained in part by oocyte quality. Since follicular fluid (FF) provides an important microenvironment for oocyte growth, we sought to evaluate the effect of increased body weight on FF levels of 11 metabolic hormones and fatty acid metabolism. METHODS: The FF was collected from 25 women (10 normal weight, 10 overweight, and 5 obese) with diminished ovarian reserve undergoing in vitro fertilization (IVF) following a minimal stimulation protocol...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29778554/cumulative-live-birth-rates-after-ivf-in-patients-with-polycystic-ovaries-phenotype-matters
#15
Michel De Vos, Stéphanie Pareyn, Panagiotis Drakopoulos, José M Raimundo, Ellen Anckaert, Samuel Santos-Ribeiro, Nikolaos P Polyzos, Herman Tournaye, Christophe Blockeel
RESEARCH QUESTION: Do cumulative live birth rates (CLBR) vary among women with different polycystic ovary syndrome (PCOS) phenotypes who undergo IVF/intracytoplasmic sperm injection (ICSI) treatment? DESIGN: In this retrospective cohort study, data from 567 patients undergoing an assisted reproductive technology (ART) cycle between January 2010 and December 2015 were collected. Demographical traits, cycle characteristics and clinical and laboratory data were analysed...
May 7, 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29778392/ultrasound-guided-follicle-aspiration-at-time-of-laparotomy-in-a-patient-with-mayer-rokitansky-k%C3%A3-ster-hauser-syndrome
#16
Ashley M Eskew, Darcy E Broughton, Maureen B Schulte, Kenan R Omurtag, Randall R Odem
OBJECTIVE: To demonstrate a unique case of direct ultrasound-guided follicle aspiration at time of a laparotomy in a patient with Mayer-Rokitansky-Küster-Hauser Syndrome. DESIGN: Video presentation. SETTING: Academic fertility center PATIENT(S): A 32-year-old gravida 0 with Mayer-Rokitansky-Küster-Hauser Syndrome and bilateral ovarian masses presented as a fertility preservation consult from gynecologic oncology due to the possibility of bilateral oophorectomy...
May 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29778386/ovarian-stimulation-in-infertile-women-treated-with-the-use-of-intrauterine-insemination-a-cohort-study-from-china
#17
Shuo Huang, Rui Wang, Rong Li, Haiyan Wang, Jie Qiao, Ben Willem J Mol
OBJECTIVE: To study the effectiveness of different ovarian stimulation protocols compared with natural cycle treatment in an intrauterine insemination (IUI) program. DESIGN: Retrospective cohort study. SETTING: Large reproductive medicine center. PATIENT(S): Couples with unexplained or mild male-factor infertility. INTERVENTION(S): Couples were treated with the use of natural-cycle IUI, or IUI after ovarian stimulation with the use of clomiphene citrate (CC), letrozole, or gonadotropins...
May 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29778366/introduction-management-of-the-luteal-phase-in-assisted-reproductive-technology
#18
Georg Griesinger, David Meldrum
The increasing utilization of a gonadotropin-releasing hormone agonist ovulation trigger and the widespread use of artificial cycles for the transfer of frozen-thawed or donated embryos has renewed interest in the luteal phase in assisted reproductive technology. The "luteal phase defect" phenomenon is now understood as a continuum: there is less impairment with milder stimulation than with more intense ovarian stimulation, and less impairment after controlled ovarian stimulation and human chorionic gonadotropin ovulation triggering than after gonadotropin-releasing hormone agonist ovulation triggering, the latter being associated with rapid luteolysis...
May 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29774275/comparative-economic-study-of-the-use-of-corifollitropin-alfa-and-daily-rfsh-for-controlled-ovarian-stimulation-in-older-patients-cost-minimization-analysis-based-on-the-pursue-study
#19
Gorka Barrenetxea, Juan Antonio García-Velasco, Belén Aragón, Jordi Osset, Max Brosa, Noemí López-Martínez, Buenaventura Coroleu
This study presents an economic assessment of controlled ovarian stimulation in assisted reproductive technology procedures in Spain, comparing the use of corifollitropin alfa and various forms of recombinant follicle-stimulating hormone (rFSH) in women of advanced maternal age. A cost-minimization analysis (CMA) was performed to assess the cost per cycle of controlled controlled ovarian stimulation, including only direct costs associated with the stimulation phase. The CMA was based on the population characteristics, the protocol, and the results obtained from the PURSUE study, taking into account 9 days of controlled controlled ovarian stimulation and 300 IU rFSH/day...
April 2018: Reproductive Biomedicine & Society Online
https://www.readbyqxmd.com/read/29773699/comparison-of-the-effect-of-immediate-versus-delayed-transfer-following-a-stimulated-ivf-cycle-on-the-ongoing-pregnancy-rate-of-frozen-thawed-embryo-transfer-cycles-a-study-protocol-for-a-randomised-controlled-trial
#20
He Li, Lu Li, Xiang Lu, Xiaoxi Sun, Ernest Hung Yu Ng
INTRODUCTION: Frozen-thawed embryo transfer (FET) has become an increasingly important part of in-vitro fertilisation (IVF) treatment. Currently, there is still no good scientific evidence to support when to perform FET following a stimulated IVF cycle. Since all published studies are retrospective and the findings are contradictory, a randomised controlled study is needed to provide Level 1 evidence to guide the clinical practice. METHODS/ANALYSIS: This is a randomised controlled trial...
May 17, 2018: BMJ Open
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