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Ovarian stimulation protocol

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https://www.readbyqxmd.com/read/28721178/global-reproductive-health-why-do-we-persist-in-neglecting-the-undeniable-problem-of-childlessness-in-resource-poor-countries
#1
EDITORIAL
W Ombelet, J Goossens
The consequences of involuntary childlessness in developing countries create more wide-ranging societal problems compared to Western societies, particularly for women. Negative psychosocial and economical consequences for childless couples are often severe and underestimated by the local and international society. Infertility treatment is often limited to certain procedures and certain costumers. Most common arguments against supporting infertility care in resource-poor countries are the "overpopulation" and the "limited resources" argument, but they totally neglect the reproductive rights and systematic exclusion of millions of women from the right to reproduce...
March 2017: Facts, Views & Vision in ObGyn
https://www.readbyqxmd.com/read/28710053/stimulation-of-the-ovaries-in-women-with-breast-cancer-undergoing-fertility-preservation-alternative-versus-standard-stimulation-protocols-the-study-protocol-of-the-stim-trial
#2
T Dahhan, E M E Balkenende, C C M Beerendonk, K Fleischer, D Stoop, A M E Bos, C B Lambalk, R Schats, R J T van Golde, J Schipper, L A Louwe, A E P Cantineau, J M J Smeenk, J P de Bruin, N Reddy, Y Kopeika, F van der Veen, M van Wely, S C Linn, M Goddijn
BACKGROUND: Chemotherapy for breast cancer may have a negative impact on reproductive function due to gonadotoxicity. Fertility preservation via banking of oocytes or embryos after ovarian stimulation with FSH can increase the likelihood of a future live birth. It has been hypothesized that elevated serum estrogen levels during ovarian stimulation may induce breast tumour growth. This has led to the use of alternative stimulation protocols with addition of tamoxifen or letrozole. The effectiveness of these stimulation protocols in terms of oocyte yield is unknown...
July 11, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28706366/gnrh-antagonist-cetrorelix-administration-before-hcg-for-protection-of-ovarian-hyperstimulation-syndrome
#3
Sherif A Hebisha, Banan A Aboelazm, H N Sallam
OBJECTIVE: Studying the effect of GnRH antagonist administration on the day of hCG to cases of IVF/ICSI with estradiol level above 5000 ng/dl for protection of ovarian hyperstimulation syndrome. DESIGN: Prospective study. MATERIALS AND METHODS: Sixty patients undergoing controlled hyperstimulation COH, for IVF/ICSI using long agonist and E2 level on the day of hCG, are above 5000 ng/dl, 52 patients received single dose of cetrorelix 0.25 mg on the day of hCG, and 8 patients received two doses of 0...
August 2017: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/28683759/intravenous-neutralization-of-vascular-endothelial-growth-factor-reduces-vascular-function-permeability-of-the-ovary-and-prevents-development-of-ohss-like-symptoms-in-rhesus-monkeys
#4
C V Bishop, D M Lee, O D Slayden, X Li
BACKGROUND: Ovarian hyperstimulation syndrome (OHSS) is a disorder associated with elevated serum VEGFA following chorionic gonadotropin (hCG) exposure in controlled ovarian stimulation (COS) cycles in women. In this study, we tested the effect of intravenous VEGFA neutralization on OHSS-like symptoms and vascular function in rhesus macaques during COS cycles. METHODS: Monkeys (n = 8) were treated with 3 COS protocols and assigned randomly to groups as follows: 1) COS alone (Control, n = 5); 2) COS + VEGF mAb Avastin 19 ± 5 h before hCG (Avastin pre-hCG; n = 6); 3) COS + Avastin 3-4 days post-hCG (Avastin post-hCG; n = 4); 4) COS + Simulated Early Pregnancy (SEP n = 3); or 5) COS + SEP + Avastin (SEP + Avastin n = 3)...
July 6, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28683583/successful-controlled-ovarian-stimulation-and-vitrification-of-oocytes-in-an-adolescent-diagnosed-with-myelodysplastic-pre-malignant-clone-with-monosomy-7
#5
Valerie Laura Peddie, Abha Maheshwari
An improvement in long-term outcomes for malignancies and non-malignant conditions, together with a review of the NICE Guideline, has led to a need to provide clinical services to deal with the sequelae of disease, its treatment, and subsequent survival of young people diagnosed with cancer. In this article, we describe fertility preservation in an adolescent female diagnosed with Myelodysplastic/pre-malignant Clone with Monosomy 7 with pathophysiology like that of chronic myeloid leukaemia (CML) with known genetic markers in the tumour cells...
July 7, 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28680360/oxidative-stress-markers-in-gnrh-agonist-and-antagonist-protocols-in-ivf
#6
Lidija Tulić, Snežana Vidaković, Ivan Tulić, Marijana Ćurčić, Jelena Stojnić, Katarina Jeremić
BACKGROUND: Our aim was to study the effect of GnRH agonist and antagonist protocols of ovarian stimulation on oxidative stress parameters in serum and the influence of oxidative stress parameters change on the outcome of IVF cycles. METHODS: This prospective study included 82 patients who underwent IVF procedures. We determined SOD, MDA and SH groups in serum. Serum samples were obtained between the second and fourth day of the cycle and on the day of HCG administration during ovarian stimulation...
April 2017: Journal of Medical Biochemistry
https://www.readbyqxmd.com/read/28670424/a-comparison-of-outcomes-from-in-vitro-fertilization-cycles-stimulated-with-follicle-stimulating-hormone-plus-either-recombinant-luteinizing-hormone-or-human-menopausal-gonadotropins-in-subjects-treated-with-long-gonadotropin-releasing-hormone-agonist-protocols
#7
Nathalie Bleau, Mohammed Agdi, WeonYoung Son, SeangLin Tan, Michael H Dahan
BACKGROUND: This study compared rates of pregnancy and in vitro fertilization (IVF) parameters in subjects stimulated with follicle stimulating hormone (FSH) plus either recombinant human luteinizing hormone (r-LH) or human menopausal gonadotropin (hMG) in a long gonadotropin releasing hormone (GnRH) agonist IVF protocol. MATERIALS AND METHODS: This cohort study enrolled patients who underwent IVF stimu- lation with a long GnRH agonist protocol and received FSH plus r-LH or hMG...
July 2017: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/28661216/luteal-phase-protocol-in-poor-ovarian-response-a-comparative-study-with-an-antagonist-protocol
#8
Yan Wu, Fu-Chun Zhao, Yong Sun, Pei-Shu Liu
Objective This retrospective study compared the effect of the luteal phase ovarian stimulation protocol (LP group) with the gonadotrophin-releasing hormone (GnRH) antagonist protocol (AN group) in women with poor ovarian responses. Methods Ovarian stimulation was initiated with 225 IU of human gonadotrophin (hMG) daily. When the dominant follicle diameter exceeded 13 mm, 0.25 mg of a GnRH antagonist was used daily until human chorionic gonadotrophin (HCG) administration in the AN group. A GnRH antagonist was not used in the LP group...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28647355/random-start-ovarian-stimulation-in-women-desiring-elective-cryopreservation-of-oocytes
#9
Nigel Pereira, Anna Voskuilen-Gonzalez, Kolbe Hancock, Jovana P Lekovich, Glenn L Schattman, Zev Rosenwaks
The current study investigates the utility of random-start ovarian stimulation in women desiring elective oocyte cryopreservation. Women in the study cohort underwent random-start ovarian stimulation, and were subdivided based on the phase of the menstrual cycle that ovarian stimulation began, i.e. early follicular, late follicular or luteal phase. Women undergoing conventional cycle day (CD) 2/3 ovarian stimulation start were controls. A total of 1302 women were included - 859 (66.0%) conventional CD 2/3, 342 (26...
June 12, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28645304/validation-of-an-automated-technique-for-ovarian-cortex-dissociation-isolation-of-viable-ovarian-cells-and-their-qualification-by-multicolor-flow-cytometry
#10
Tristan Zver, Elodie Mouloungui, Aurélie Berdin, Christophe Roux, Clotilde Amiot
BACKGROUND: Ovarian tissue cryopreservation is a technique for fertility preservation addressed to prepubertal girls or to patients for whom no ovarian stimulation is possible before initiation of gonadotoxic treatments. Autotransplantation of frozen-thawed ovarian tissue is the only available option for reuse but presents some limitations: ischemic tissue damages post-transplant and reintroduction of malignant cells in cases of cancer. It is therefore essential to qualify ovarian tissue before autograft on a functional and oncological point of view...
June 23, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28625761/impact-of-vitamin-d-levels-on-ovarian-reserve-and-ovarian-response-to-ovarian-stimulation-in-oocyte-donors
#11
Alberta Maria Fabris, Maria Cruz, Carlos Iglesias, Alberto Pacheco, Azadeh Patel, Jayesh Patel, Human Fatemi, Juan Antonio García-Velasco
Recently, growing interest in vitamin D has emerged from findings that demonstrate a low vitamin D status in populations. Similarly, much interest has been shown in the role that anti-Müllerian hormone (AMH) plays in reproductive physiology. Considerable confusion as to whether vitamin D status is related to ovarian function can be found in the literature. Our retrospective study was performed from June 2014 to April 2015. Oocyte donors were recruited and stimulated under the antagonist protocol with gonadotrophin-releasing hormone (GnRH) agonist to trigger ovulation...
May 19, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28621049/lower-foxo3-mrna-expression-in-granulosa-cells-is-involved-in-unexplained-infertility
#12
Hikaru Yamamoto, Yoshiki Yamashita, Natsuho Saito, Atsushi Hayashi, Masami Hayashi, Yoshito Terai, Masahide Ohmichi
AIM: The aim of this study was to investigate whether FOXO1 and FOXO3 mRNA expression in granulosa cells is the cause of unexplained infertility. METHODS: Thirty-one patients aged <40 years (13 with unexplained infertility and 18 with male partner infertility as a control group) whose serum anti-Müllerian hormone level was >0.5 ng/μL were enrolled in the study. All patients underwent oocyte retrieval under a short protocol from June 2012 to October 2013...
June 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28620352/efficacy-of-follicle-stimulating-hormone-fsh-alone-fsh%C3%A2-%C3%A2-luteinizing-hormone-human-menopausal-gonadotropin-or-fsh%C3%A2-%C3%A2-human-chorionic-gonadotropin-on-assisted-reproductive-technology-outcomes-in-the-personalized-medicine-era-a-meta-analysis
#13
Daniele Santi, Livio Casarini, Carlo Alviggi, Manuela Simoni
SETTING: Luteinizing hormone (LH) and human chorionic gonadotropin (hCG) act on the same receptor, activating different signal transduction pathways. The role of LH or hCG addition to follicle-stimulating hormone (FSH) as well as menopausal gonadotropins (human menopausal gonadotropin; hMG) in controlled ovarian stimulation (COS) is debated. OBJECTIVE: To compare FSH + LH, or FSH + hCG or hMG vs. FSH alone on COS outcomes. DESIGN: A meta-analysis according to PRISMA statement and Cochrane Collaboration was performed, including prospective, controlled clinical trials published until July 2016, enrolling women treated with FSH alone or combined with other gonadotropins...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28617534/afc-vs-amh-prediction-of-ovarian-response-in-women-with-endometrioma-undergoing-controlled-ovarian-stimulation
#14
A A Ersahin, H Arpaci, S S Ersahin, N Celik, M Acet
OBJECTIVE: To assess the clinical value of antral follicle count (AFC) and anti-Mullerian hormone (AMH) for the prediction of ovarian response in women with endometrioma undergoing controlled ovarian stimulation for IVF using GnRH antagonist treatment. PATIENTS AND METHODS: Fifty patients with endometrioma who underwent their first IVF/ICSI cycle with GnRH antagonist treatment were included in the study. The average AMH values were recorded as 1.5-2 ng/mL. Fifty infertile women are not suffering from endometrioma were selected from those with male factor infertility as control...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28609269/corifollitropin-alfa-compared-to-daily-rfsh-or-hp-hmg-in-gnrh-antagonist-controlled-ovarian-stimulation-protocol-for-patients-undergoing-assisted-reproduction
#15
Priscila Morais Galvão Souza, Bruno Ramalho de Carvalho, Hitomi Miura Nakagawa, Thalita Reis Esselin Rassi, Antônio César Paes Barbosa, Adelino Amaral Silva
OBJECTIVE: This study aimed to compare the outcomes of controlled ovarian stimulation (COS) with corifollitropin alfa versus daily recombinant follicle-stimulating hormone (rRFSH) or highly purified human menopausal gonadotropin (HP-HMG) in patients undergoing in vitro fertilization (IVF) cycles based on gonadotropin-releasing hormone (GnRH) antagonist protocols. The primary endpoints were total number of oocytes and mature oocytes. METHODS: This retrospective study looked into 132 controlled ovarian stimulation cycles from IVF or oocyte cryopreservation performed in a private human reproduction center between January 1 and December 31, 2014...
June 1, 2017: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/28601158/effect-of-corifollitropin-alfa-supplemented-with-or-without-lh-on-ovarian-stimulation-and-embryo-viability-in-rabbit
#16
María Pilar Viudes-de-Castro, Francisco Marco-Jiménez, José Isaí Cedano-Castro, José Salvador Vicente
There is increasing interest in using rabbits for research as a laboratory model as well as for industrial production of meat, wool and fur. Superovulation in animals is used to produce a maximum number of transferable embryos per donor, in order to either support genetic improvement programs, ex situ conservation or to optimize other biotechnologies. Over time, the use of this biotechnology has shown variable outcomes as a consequence of several factors, such as the origin of exogenous hormone, posology and the effect of gonadotropins used simultaneously, the donor and the environment...
August 2017: Theriogenology
https://www.readbyqxmd.com/read/28583140/live-birth-after-fresh-versus-frozen-single-blastocyst-transfer-frefro-blastocyst-study-protocol-for-a-randomized-controlled-trial
#17
Daimin Wei, Yun Sun, Jiayin Liu, Xiaoyan Liang, Yimin Zhu, Yuhua Shi, Zi-Jiang Chen
BACKGROUND: Multiple pregnancies are one of the major safety concerns of in vitro fertilization (IVF) due to the increased risk of maternal and neonatal complications. Single embryo transfer is the most effective way to reduce the risk of multiple pregnancies. Selection of the embryo and optimization of the implantation environment are crucial to retain the success rate when the number of transferred embryos is diminished. Fresh embryo transfer with supra-physiological levels of hormones has been suggested to have an adverse effect on implantation...
June 5, 2017: Trials
https://www.readbyqxmd.com/read/28550023/the-super-study-protocol-for-a-randomised-controlled-trial-comparing-follicle-stimulating-hormone-and-clomiphene-citrate-for-ovarian-stimulation-in-intrauterine-insemination
#18
N A Danhof, M van Wely, Cam Koks, J Gianotten, J P de Bruin, B J Cohlen, D P van der Ham, N F Klijn, Mha van Hooff, Fjm Broekmans, K Fleischer, Cah Janssen, J M Rijn van Weert, J van Disseldorp, M Twisk, M Traas, Mfg Verberg, M J Pelinck, J Visser, Dam Perquin, DES Boks, H R Verhoeve, C F van Heteren, Bwj Mol, S Repping, F van der Veen, M H Mochtar
OBJECTIVE: To study the effectiveness of four cycles of intrauterine insemination (IUI) with ovarian stimulation (OS) by follicle-stimulating hormone (FSH) or by clomiphene citrate (CC), and adherence to strict cancellation criteria. SETTING: Randomised controlled trial among 22 secondary and tertiary fertility clinics in the Netherlands. PARTICIPANTS: 732 women from couples diagnosed with unexplained or mild male subfertility and an unfavourable prognosis according to the model of Hunault of natural conception...
May 25, 2017: BMJ Open
https://www.readbyqxmd.com/read/28540977/oral-contraceptive-pill-progestogen-or-oestrogen-pretreatment-for-ovarian-stimulation-protocols-for-women-undergoing-assisted-reproductive-techniques
#19
REVIEW
Cindy Farquhar, Luk Rombauts, Jan Am Kremer, Anne Lethaby, Reuben Olugbenga Ayeleke
BACKGROUND: Among subfertile women undergoing assisted reproductive technology (ART), hormone pills given before ovarian stimulation may improve outcomes. OBJECTIVES: To determine whether pretreatment with the combined oral contraceptive pill (COCP) or with a progestogen or oestrogen alone in ovarian stimulation protocols affects outcomes in subfertile couples undergoing ART. SEARCH METHODS: We searched the following databases from inception to January 2017: Cochrane Gynaecology and Fertility Group Specialised Register, The Cochrane Central Register Studies Online, MEDLINE, Embase, CINAHL and PsycINFO...
May 25, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28539318/serum-estradiol-levels-in-controlled-ovarian-stimulation-directly-affect-the-endometrium
#20
Kamran Ullah, Tanzil Ur Rahman, Hai-Tao Pan, Meng-Xi Guo, Xin-Yan Dong, Juan Liu, Lu-Yang Jin, Yi Cheng, Zhang-Hong Ke, Jun Ren, Xian-Hua Lin, Xiao-Xiao Qiu, Ting-Ting Wang, He-Feng Huang, Jian-Zhong Sheng
Previous studies have shown that increasing estradiol concentrations had a toxic effect on the embryo and were deleterious to embryo adhesion. In this study, we evaluated the physiological impact of estradiol concentrations on endometrial cells to reveal that serum estradiol levels probably targeted the endometrium in controlled ovarian hyperstimulation (COH) protocols. An attachment model of human choriocarcinoma (JAr) cell spheroids to receptive-phase endometrial epithelial cells and Ishikawa cells treated with different estradiol (10(-9) M or 10(-7) M) concentrations was developed...
August 2017: Journal of Molecular Endocrinology
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