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https://www.readbyqxmd.com/read/29228519/large-scale-surveillance-study-of-the-safety-and-effectiveness-of-entecavir-in-korean-patients-with-chronic-hepatitis-b
#1
Chang Wook Kim, Chang Seop Kim, Hee Yeon Kim, Chang Don Lee, Kyungha Yu, Cyril Llamoso, Heon Ju Lee
Background/Aims: Entecavir (ETV) is effective and safe antiviral agent against hepatitis B virus (HBV) in clinical and real-world setting but, most studies were performed in single institute or have limitation in patient's number. A large-scale nation-wide real-world surveillance study was carried out to investigate safety, efficacy and clinical effectiveness of ETV in Korean patients with chronic hepatitis B (CHB). Methods: Between 2006 and 2012, 3,444 patients were enrolled from 132 Korean institutions...
December 13, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29226310/long-term-behavioural-outcomes-after-paediatric-convulsive-status-epilepticus-a-population-based-cohort-study
#2
Marina M Martinos, Suresh Pujar, Christopher Gillberg, Mario Cortina-Borja, Brian G R Neville, Michelle De Haan, Rod C Scott, Richard F M Chin
AIM: To describe behavioural and psychiatric outcomes of children within 10 years of convulsive status epilepticus (CSE). METHOD: Children originally identified by the population-based North London Convulsive Status Epilepticus in Childhood Surveillance Study were followed-up between July 2009 and February 2013. They were grouped into epilepsy- and non-epilepsy-related CSE, and compared with population norms and healthy controls using the Strengths and Difficulties Questionnaire; the Autism Spectrum Screening Questionnaire; and the Swanson, Nolan, and Pelham questionnaire...
December 10, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29226251/tissue-based-biomarkers-in-prostate-cancer
#3
Timothy N Clinton, Aditya Bagrodia, Yair Lotan, Vitaly Margulis, Ganesh V Raj, Solomon L Woldu
Introduction: Prostate cancer is a heterogeneous disease. Existing risk stratification tools based on standard clinlicopathologic variables (prostate specific antigen [PSA], Gleason score, and tumor stage) provide a modest degree of predictive ability. Advances in high-throughput sequencing has led to the development of several novel tissue-based biomarkers that can improve prognostication in prostate cancer management. Areas Covered: The authors review commercially-available, tissue-based biomarker assays that improve upon existing risk-stratification tools in several areas of prostate cancer management, including the appropriateness of active surveillance and aiding in decision making regarding the use of adjuvant therapy...
2017: Expert Review of Precision Medicine and Drug Development
https://www.readbyqxmd.com/read/29225779/risk-of-solid-cancer-in-patients-with-mast-cell-activation-syndrome-results-from-germany-and-usa
#4
Gerhard J Molderings, Thomas Zienkiewicz, Jürgen Homann, Markus Menzen, Lawrence B Afrin
Background:  It has been shown repeatedly that mast cells can promote or prevent cancer development and growth. If development and/or progression of a solid cancer is substantially influenced by mast cell activity, the frequencies of occurrence of solid cancers in patients with primary mast cells disorders would be expected to differ from the corresponding prevalence data in the general population. In fact, a recent study demonstrated that patients with systemic mastocytosis (i.e., a rare neoplastic variant of the primary mast cell activation disease) have increased risk for solid cancers, in particular melanoma and non-melanoma skin cancers...
2017: F1000Research
https://www.readbyqxmd.com/read/29225413/outbreak-of-hospital-infection-from-biofilm-embedded-pan-drug-resistant-pseudomonas-aeroginosa-due-to-a-contaminated-bronchoscope
#5
Nader Alipour, Alper Karagoz, Abbas Taner, Nasrin Gaeini, Nastaran Alipour, Hassan Zeytin, Fatih Yildiz, Riza Durmaz
Background: Colistin-resistant Pseudomonas aeruginosa (P. aeruginosa) has been defined as pandrug-resistant (PDR) strain. Outbreaks of PDR P. aeruginosa especially in pulmonary tract infections due to contaminated bronchoscopes have rarely been reported. The emergence of pandrug-resistant strains in both CF (Cystic Fibrosis) and non-CF clinical isolates over recent years remains of a great concern. Hospital wards contaminated with PDR P. aeruginosa infection, must be shot down until their eradication...
2017: Tap Chi y Hoc du Phong, Journal of Preventive Medicine / Hoi y Hoc du Phong Viet Nam
https://www.readbyqxmd.com/read/29225124/time-delays-in-the-diagnosis-and-treatment-of-malaria-in-non-endemic-countries-a-systematic-review
#6
REVIEW
Hamad Bastaki, Jessica Carter, Louise Marston, Jackie Cassell, Greta Rait
BACKGROUND: Delays in diagnosis and treatment for malaria are associated with an increased risk for severe disease and mortality. Identifying the extent of patient and health system delay can provide a benchmark against which interventions to reduce delays can be measured. METHODS: We performed an electronic search in PubMed, EMBASE, Web of Science and LILACS for studies reporting time to diagnosis and treatment after return from travel, onset of symptoms and seeking healthcare in non-endemic countries...
December 7, 2017: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29224710/spm-1-producing-pseudomonas-aeruginosa-st277-clone-recovered-from-microbiota-of-migratory-birds
#7
Willames M B S Martins, Ana Clara Narciso, Rodrigo Cayô, Stéfanie Vanessa Santos, Lorena C C Fehlberg, Patrícia Locosque Ramos, João Batista da Cruz, Ana Cristina Gales
The production of São Paulo metallo-β-lactamase (SPM-1) is the most common carbapenem resistance mechanism detected among multidrug-resistant Pseudomonas aeruginosa clinical isolates in Brazil. Dissemination of SPM-1-producing P. aeruginosa has been restricted to the nosocomial settings, with sporadic reports of environmental isolates due to contamination by hospital sewage. Herein, we described the detection and molecular characterization of SPM-1-producing P. aeruginosa recovered from the microbiota of migratory birds in Brazil...
November 10, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29224637/valve-hemodynamic-deterioration-and-cardiovascular-outcomes-in-tavr-a-report-from-the-sts-acc-tvt-registry
#8
Sreekanth Vemulapalli, David R Holmes, David Dai, Roland Matsouaka, Michael J Mack, Fred L Grover, Raj R Makkar, Vinod H Thourani, Pamela S Douglas
BACKGROUND: Recent reports of leaflet abnormalities (detected using advanced imaging) have raised questions regarding transcatheter aortic valve replacement (TAVR) durability. We sought to determine the incidence of valve hemodynamic deterioration (VHD) and its association with cardiovascular outcomes. METHODS AND RESULTS: Consecutive cases with paired postimplant and follow-up echocardiograms from November 2011 to March 2015 in the STS/ACC TVT Registry were allocated into 2 overlapping cohorts: early (paired echocardiograms at 0 and 30 days) and late (paired echocardiograms at 30 days and 1 year)...
January 2018: American Heart Journal
https://www.readbyqxmd.com/read/29224317/-a-multicenter-retrospective-study-of-pathogenic-bacteria-distribution-and-drug-resistance-in-febrile-neutropenic-patients-with-hematological-diseases-in-shanghai
#9
J Zhu, J Hu, Y F Mao, F Y Chen, J Y Zhu, J M Shi, D D Yu, S G Hao, R Tao, P Liu, S Y Gu, J Hou, H Y He, A B Liang, Y Ding, L G Liu, Y H Xie, Q Zhu, Y H Yu, Y H Yao, W Chen, H L Xu, X H Han, C Wang
Objective: To investigate the pathogen spectrum distribution and drug resistance of febrile neutropenic patients with hematological diseases in Shanghai. Methods: A retrospective study was conducted on the clinical isolates from the febrile neutropenic patients hospitalized in the departments of hematology in 12 general hospitals in Shanghai from January 2012 to December 2014. The drug susceptibility test was carried out by Kirby-Bauer method. WHONET 5.6 software was used to analyze pathogenic bacteria and drug susceptibility data...
November 14, 2017: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/29223965/advancing-prevention-of-sexually-transmitted-infections-through-point-of-care-testing-target-product-profiles-and-landscape-analysis
#10
Igor Toskin, Maurine Murtagh, Rosanna W Peeling, Karel Blondeel, Joanna Cordero, James Kiarie
OBJECTIVES: Advancing the field of point-of-care testing (POCT) for STIs can rapidly and substantially improve STI control and prevention by providing targeted, essential STI services (case detection and screening). POCT enables definitive diagnosis and appropriate treatment in a single visit and home and community-based testing. METHODS: Since 2014, the WHO Department of Reproductive Health and Research, in collaboration with technical partners, has completed four landscape analyses of promising diagnostics for use at or near the point of patient care to detect syphilis, Neisseria gonorrhoeae, Chlamydia trachomatis, Trichomonas vaginalis and the human papillomavirus...
December 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29223276/a-51-year-old-woman-with-an-increasing-chest-wall-mass-years-after-resection-of-an-early-stage-lung-cancer
#11
Ajay Dhakal, Hongbin Chen, Elisabeth U Dexter
A 51-year-old woman was found to have a new 14 × 6 mm soft tissue mass under the right serratus muscle on a CT scan of the chest performed for routine surveillance due to her history of stage I lung cancer. A follow-up CT scan performed 4 months later showed that the mass had increased in size to 22 × 8 mm. The patient presents to the oncology clinic to discuss the results of the CT scan. She has no pain or swelling on the right lateral chest and no cough, fever, or shortness of breath. She is at her baseline health with good appetite and functional status...
December 2017: Chest
https://www.readbyqxmd.com/read/29222426/surveillance-of-antibiotic-resistance-among-common-clostridium-difficile-ribotypes-in-hong-kong
#12
Viola C Y Chow, Thomas N Y Kwong, Erica W M So, Yolanda I I Ho, Sunny H Wong, Raymond W M Lai, Raphael C Y Chan
Incidence of Clostridium difficile infection (CDI) is rapidly increasing and it poses a major health burden globally. However, data regarding the epidemiology of CDI in Asia are limited. We aimed to characterize the antimicrobial susceptibility patterns of common ribotypes of toxigenic C. difficile in Hong Kong. Fifty-three PCR ribotypes were identified among 284 toxigenic C. difficile clinical isolates. The five most prevalent ribotypes were 002 (13%), 017 (12%), 014 (10%), 012 (9.2%), and 020 (9.5%). All tested C...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29222262/pediatric-leukemia-susceptibility-disorders-manifestations-and-management
#13
REVIEW
Lisa J McReynolds, Sharon A Savage
The clinical manifestations of inherited susceptibility to leukemia encompass a wide phenotypic range, including patients with certain congenital anomalies or early-onset myelodysplastic syndrome (MDS) and some with no obvious medical problems until they develop leukemia. Leukemia susceptibility syndromes occur as a result of autosomal dominant, autosomal recessive, or X-linked recessive inheritance, or de novo occurrence, of germline pathogenic variants in DNA repair, ribosome biogenesis, telomere biology, hematopoietic transcription factors, tumor suppressors, and other critical cellular processes...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/29222045/challenges-in-risk-estimation-using-routinely-collected-clinical-data-the-example-of-estimating-cervical-cancer-risks-from-electronic-health-records
#14
Rebecca Landy, Li C Cheung, Mark Schiffman, Julia C Gage, Noorie Hyun, Nicolas Wentzensen, Walter K Kinney, Philip E Castle, Barbara Fetterman, Nancy E Poitras, Thomas Lorey, Peter D Sasieni, Hormuzd A Katki
Electronic health-records (EHR) are increasingly used by epidemiologists studying disease following surveillance testing to provide evidence for screening intervals and referral guidelines. Although cost-effective, undiagnosed prevalent disease and interval censoring (in which asymptomatic disease is only observed at the time of testing) raise substantial analytic issues when estimating risk that cannot be addressed using Kaplan-Meier methods. Based on our experience analysing EHR from cervical cancer screening, we previously proposed the logistic-Weibull model to address these issues...
December 5, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/29221766/screening-for-fetal-growth-restriction-and-placental-insufficiency
#15
REVIEW
Melanie C Audette, John C Kingdom
Fetal growth restriction (FGR) continues to be a leading cause of preventable stillbirth and poor neurodevelopmental outcomes in offspring, and furthermore is strongly associated with the obstetrical complications of iatrogenic preterm birth and pre-eclampsia. The terms small for gestational age (SGA) and FGR have, for too long, been considered equivalent and therefore used interchangeably. However, the delivery of improved clinical outcomes requires that clinicians effectively distinguish fetuses that are pathologically growth-restricted from those that are constitutively small...
December 5, 2017: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29221275/patterns-of-distant-organ-metastases-in-esophageal-cancer-a-population-based-study
#16
Dashan Ai, Hanting Zhu, Wenjia Ren, Yun Chen, Qi Liu, Jiaying Deng, Jinjun Ye, Jianhong Fan, Kuaile Zhao
Background: Esophageal cancer is the eighth most common cancer worldwide. The prognosis of esophageal cancer patients is dismal, especially those with distant organ metastasis. However, there are few studies describing the patterns of distant metastasis in esophageal cancer systematically. Methods: We gathered the data from Surveillance Epidemiology and End Results (SEER) database between 2010 and 2013. Categorical variables were analyzed by the Pearson Chi square test, and continuous variables were analyzed by the two-sample t test...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221214/prognostic-value-of-mica-b-in-cancers-a-systematic-review-and-meta-analysis
#17
Yijing Zhao, Naifei Chen, Yu Yu, Lili Zhou, Chao Niu, Yudi Liu, Huimin Tian, Zheng Lv, Fujun Han, Jiuwei Cui
Purpose: MHC class I chain related-proteins A (MICA) and B (MICB) are natural killer group 2D ligands that mediate tumor surveillance. Several studies have suggested that MICA/B levels predict clinical outcomes in patients with cancer; however, this remains contentious. Here, we present a systematic review and meta-analysis of available studies of the prognostic value of MICA/B in cancer. Materials and Methods: We searched PubMed, Embase, Clinicaltrials.gov, and Cochrane Library to identify studies published from inception to July 2017 that assessed MICA/B in patients with cancer...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29220860/patients-willingness-to-defer-resection-of-diminutive-polyps-results-of-a-multicenter-survey
#18
Daniel von Renteln, Mickael Bouin, Alan N Barkun, Audrey Weber, Douglas J Robertson, Joseph C Anderson, Heiko Pohl
Background and study aims Current colonoscopy practice requires removal of diminutive polyps. This is associated with costs, but the benefits to colorectal cancer (CRC) prevention remain unclear. The study aim was to understand patients' willingness to defer resection of diminutive polyps and to examine the factors that influence patients' decisions. Patients and methods Adults presenting for a colonoscopy were surveyed at three hospitals in the USA and Canada. Survey domains included: patient characteristics, risk perception, knowledge about CRC risk, willingness to defer polyp resection, and associated concerns...
December 8, 2017: Endoscopy
https://www.readbyqxmd.com/read/29220288/contemporary-sarcoma-diagnosis-genetics-and-genomics
#19
Inga-Marie Schaefer, Gregory M Cote, Jason L Hornick
Sarcomas include diverse mesenchymal neoplasms with widely varied prognosis, clinical behavior, and treatment. Owing to their rarity and histologic overlap, accurate diagnosis of sarcomas can be challenging. Our approach has evolved dramatically in the past few decades, where novel insights into the molecular pathogenetic basis for sarcomas has dramatically (re)shaped contemporary diagnosis, building on a largely morphology- and clinical presentation-based strategy. Examples include the introduction of novel immunohistochemical markers that serve as surrogates for molecular genetic alterations and identification of characteristic molecular alterations...
December 8, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29220209/making-time-for-patients-positive-impact-of-direct-patient-reporting
#20
Sheila K Mohan, Patricia A Hudgins, Mihir R Patel, Jim Stapleton, Richard Duszak, Ashley H Aiken
OBJECTIVE: Using a novel patient-centric approach, we assessed the impact of direct patient radiology reporting on the patient experience and patient perception of radiologists in a high-volume head and neck clinic. MATERIALS AND METHODS: A single head and neck surgeon at a large academic center identified prospective outpatients who met the following inclusion criteria: having received treatment for head and neck cancer and having recently undergone surveillance imaging using the Neck Imaging Reporting and Data System template at our institution...
December 8, 2017: AJR. American Journal of Roentgenology
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