Luise Fischer, Nora Grieb, Patrick Born, Ronald Weiss, Sabine Seiffert, Andreas Boldt, Stephan Fricke, Paul Franz, Simone Heyn, Anne Sophie Kubasch, Ronny Baber, Heike Weidner, Song Yau Wang, Enrica Bach, Sandra Hoffmann, Jule Ussmann, Janine Kirchberg, Saskia Hell, Sebastian Schwind, Klaus H Metzeler, Marco Herling, Madlen Jentzsch, Georg-Nikolaus Franke, Ulrich Sack, Kristin Reiche, Ulrike Köhl, Uwe Platzbecker, Vladan Vucinic, Maximilian Merz
B-cell maturation antigen (BCMA)-targeting chimeric antigen receptor (CAR) T cells revolutionized the treatment of relapsed/refractory multiple myeloma (RRMM). However, data on cellular (CAR) T cell dynamics and the association with response, resistance or the occurrence of cytokine release syndrome (CRS) are limited. Therefore, we performed a comprehensive flow cytometry analysis of 27 RRMM patients treated with Idecabtagene vicleucel (Ide-cel) to assess the expansion capacity, persistence and effects on bystander cells of BCMA-targeting CAR T cells...
January 6, 2024: Leukemia