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Post partum depression

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https://www.readbyqxmd.com/read/28619476/brexanolone-sage-547-injection-in-post-partum-depression-a-randomised-controlled-trial
#1
Stephen Kanes, Helen Colquhoun, Handan Gunduz-Bruce, Shane Raines, Ryan Arnold, Amy Schacterle, James Doherty, C Neill Epperson, Kristina M Deligiannidis, Robert Riesenberg, Ethan Hoffmann, David Rubinow, Jeffrey Jonas, Steven Paul, Samantha Meltzer-Brody
BACKGROUND: Post-partum depression is a serious mood disorder in women that might be triggered by peripartum fluctuations in reproductive hormones. This phase 2 study investigated brexanolone (USAN; formerly SAGE-547 injection), an intravenous formulation of allopregnanolone, a positive allosteric modulator of γ-aminobutyric acid (GABAA) receptors, for the treatment of post-partum depression. METHODS: For this double-blind, randomised, placebo-controlled trial, we enrolled self-referred or physician-referred female inpatients (≤6 months post partum) with severe post-partum depression (Hamilton Rating Scale for Depression [HAM-D] total score ≥26) in four hospitals in the USA...
June 12, 2017: Lancet
https://www.readbyqxmd.com/read/28619475/post-partum-depression-a-glimpse-of-light-in-the-darkness
#2
Ian Jones
No abstract text is available yet for this article.
June 12, 2017: Lancet
https://www.readbyqxmd.com/read/28610830/mutual-regulation-between-infant-facial-affect-and-maternal-touch-in-depressed-and-nondepressed-dyads
#3
Ida Egmose, Katharina Cordes, Johanne Smith-Nielsen, Mette Skovgaard Væver, Simo Køppe
The ability to regulate affect is important for later adaptive child development. In the first months of life, infants have limited resources for regulating their own affects (e.g. by gaze aversion), and for this reason they are dependent on external affect regulation from their parents. Previous research suggests that touch is an important means through which parents regulate their infants' affects. Also, previous research has shown that post-partum depressed (PPD) mothers and nonclinical mothers differ in their touching behaviors when interacting with their infants...
June 10, 2017: Infant Behavior & Development
https://www.readbyqxmd.com/read/28588541/parenting-stress-mental-health-dyadic-adjustment-a-structural-equation-model
#4
Luca Rollè, Laura E Prino, Cristina Sechi, Laura Vismara, Erica Neri, Concetta Polizzi, Annamaria Trovato, Barbara Volpi, Sara Molgora, Valentina Fenaroli, Elena Ierardi, Valentino Ferro, Loredana Lucarelli, Francesca Agostini, Renata Tambelli, Emanuela Saita, Cristina Riva Crugnola, Piera Brustia
Objective: In the 1st year of the post-partum period, parenting stress, mental health, and dyadic adjustment are important for the wellbeing of both parents and the child. However, there are few studies that analyze the relationship among these three dimensions. The aim of this study is to investigate the relationships between parenting stress, mental health (depressive and anxiety symptoms), and dyadic adjustment among first-time parents. Method: We studied 268 parents (134 couples) of healthy babies. At 12 months post-partum, both parents filled out, in a counterbalanced order, the Parenting Stress Index-Short Form, the Edinburgh Post-natal Depression Scale, the State-Trait Anxiety Inventory, and the Dyadic Adjustment Scale...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28570858/chronological-narratives-from-smoking-initiation-through-to-pregnancy-of-indigenous-australian-women-a-qualitative-study
#5
Gillian S Gould, Michelle Bovill, Marilyn J Clarke, Maree Gruppetta, Yvonne Cadet-James, Billie Bonevski
OBJECTIVE: One in two Indigenous Australian pregnant women smoke, yet little is known about their trajectory of smoking. This study aimed to explore Aboriginal women's narratives from starting smoking through to pregnancy. METHODS: A female Aboriginal Researcher conducted individual face-to-face interviews with 20 Aboriginal women from New South Wales, Australia. Recruitment, through Aboriginal services and community networks, continued until saturation was reached...
May 19, 2017: Midwifery
https://www.readbyqxmd.com/read/28527083/shared-mechanisms-of-epilepsy-migraine-and-affective-disorders
#6
Davide Zarcone, Simona Corbetta
Since the nineteenth century several clinical features have been observed in common between migraine and epilepsy (such as episodic attacks, triggering factors, presence of aura, frequent familiarity), but only in recent years researchers have really engaged in finding a common pathogenic mechanism. From studies of disease incidence, we understand how either migraine among patients with epilepsy or epilepsy among migraine patients are more frequent than in the general population. This association may result from a direct causality, by the same environmental risk factors and/or by a common genetic susceptibility...
May 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28480514/maternal-care-mediates-the-effects-of-nutrition-and-responsive-stimulation-interventions-on-young-children-s-growth
#7
N Brown, J E Finch, J Obradović, A K Yousafzai
BACKGROUND: Undernutrition contributes to at least half the estimated six million annual childhood deaths worldwide. Furthermore, one in three children fails to meet their developmental potential because of risks including stunting, illness, under-stimulation, poor responsive interactions and maternal depressive symptoms. Our study investigates the role of caregiving processes on children's height-for-age at 2 and 4 years. METHODS: The Pakistan Early Child Development Scale-up study assessed the longitudinal effectiveness of early nutrition and responsive stimulation interventions on growth and development at 4 years of age...
May 7, 2017: Child: Care, Health and Development
https://www.readbyqxmd.com/read/28476427/clinical-phenotypes-of-perinatal-depression-and-time-of-symptom-onset-analysis-of-data-from-an-international-consortium
#8
Karen T Putnam, Marsha Wilcox, Emma Robertson-Blackmore, Katherine Sharkey, Veerle Bergink, Trine Munk-Olsen, Kristina M Deligiannidis, Jennifer Payne, Margaret Altemus, Jeffrey Newport, Gisele Apter, Emmanuel Devouche, Alexander Viktorin, Patrik Magnusson, Brenda Penninx, Anne Buist, Justin Bilszta, Michael O'Hara, Scott Stuart, Rebecca Brock, Sabine Roza, Henning Tiemeier, Constance Guille, C Neill Epperson, Deborah Kim, Peter Schmidt, Pedro Martinez, Arianna Di Florio, Katherine L Wisner, Zachary Stowe, Ian Jones, Patrick F Sullivan, David Rubinow, Kevin Wildenhaus, Samantha Meltzer-Brody
BACKGROUND: The perinatal period is a time of high risk for onset of depressive disorders and is associated with substantial morbidity and mortality, including maternal suicide. Perinatal depression comprises a heterogeneous group of clinical subtypes, and further refinement is needed to improve treatment outcomes. We sought to empirically identify and describe clinically relevant phenotypic subtypes of perinatal depression, and further characterise subtypes by time of symptom onset within pregnancy and three post-partum periods...
May 3, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28455085/randomized-controlled-trial-of-intravenous-acetaminophen-for-postcesarean-delivery-pain-control
#9
Brie Altenau, Catrina C Crisp, C Ganga Devaiah, Donna S Lambers
BACKGROUND: Cesarean delivery is a common surgery in the United States, with 1.3 million performed during 2009.(1) Obstetricians must balance the growing concern with opioid abuse, dependence, and side effects with optimal postoperative pain control. Intravenous acetaminophen may represent an additional method to decrease the reliance on opioid medications and improve postoperative pain following cesarean delivery. OBJECTIVE: The objective of the study was to determine whether the administration of intravenous acetaminophen following routine scheduled cesarean delivery would decrease the need for narcotic medications to control postoperative pain...
April 25, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28454929/real-world-usage-of-educational-media-does-not-promote-parent-child-cognitive-stimulation-activities
#10
Jason H Choi, Alan L Mendelsohn, Adriana Weisleder, Carolyn Cates, Caitlin Canfield, Anne Seery, Benard P Dreyer, Suzy Tomopoulos
OBJECTIVE: To determine whether educational media as actually used by low-income families promotes parent-child cognitive stimulation activities. METHODS: Secondary analysis of the control group of a longitudinal cohort of mother-infant dyads enrolled post-partum in urban public hospital. Educational media exposure (via a 24-hour recall diary) and parent-child activities that may promote cognitive stimulation in the home (using StimQ) were assessed at 6, 14, 24, and 36 months...
April 25, 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/28437764/the-use-of-lithium-for-the-treatment-of-bipolar-disorder-recommendations-from-clinical-practice-guidelines
#11
Gin S Malhi, Danielle Gessler, Tim Outhred
BACKGROUND: Lithium is an effective mood stabilizer that is used principally for the management of bipolar disorder (BD). Its administration is complex and often requires sophisticated management and assiduous monitoring. When considering the use of lithium therapy for bipolar disorder, clinicians are advised to refer to recommendations outlined in clinical practice guidelines (CPGs); but because of varying emphases placed by different international CPGs, recommendations addressing the practical use of lithium lack consistency...
August 1, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28300619/brain-neurotransmitters-in-an-animal-model-with-postpartum-depressive-like-behavior
#12
Y Avraham, Y Hants, L Vorobeiv, M Staum, Wiessam Abu Ahmad, D Mankuta, E Galun, S Arbel-Alon
Post-Partum Depression (PPD) occurs in 15% of pregnancies and its patho-physiology is not known. We studied female BALB/c ("depressive") and C57BL/6 (control) mice as a model for PPD and assessed their behavior and correlates with brain neurotransmitters (NTs) - norepinephrine, dopamine, serotonin and intermediates, during the pre-pregnancy (PREP), pregnancy (PREG) and post-partum (PP) periods. Depressive-like behavior was evaluated by the Open Field (OFT), Tail Suspension (TST) and Forced Swim (FST) tests...
March 12, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28290763/psychosocial-risk-factors-and-treatment-of-new-onset-and-recurrent-depression-during-the-post-partum-period
#13
Pirjo Kettunen, Jukka Hintikka
BACKGROUND: When developing maternity care services, it is important to know how psychosocial factors affect the course of post-partum depression (PPD), and how depressed mothers are treated. AIMS: The aim of this study is to assess how adverse childhood experiences, poor present support and violence, and low socioeconomic status (SES) associate with PPD, specifically in new onset and recurrent post-partum depression. The second aim is to assess the treatment received for PPD...
March 14, 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/28282707/post-partum-depression-effect-on-child-health-and-development
#14
Fatemeh Abdollahi, Farideh Rezai Abhari, Mehran Zarghami
While studies have shown the disastrous effects of post-partum depression (PPD) on children's behaviors, there is relatively lack of reliable data in Asian countries. This study examined the relative significance of maternal PPD in children's developmental disabilities at age four. In a longitudinal study design (2009), 1801 pregnant women attending in primary health centers of Mazandaran province in the north of Iran provided self-reports of depression from two to twelve postpartum weeks using Edinburgh Postnatal Depression Scale (EPDS)...
February 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28271578/fathers-make-a-difference-positive-relationships-with-mother-and-baby-in-relation-to-infant-colic
#15
C P Alexander, J Zhu, I M Paul, K H Kjerulff
BACKGROUND: Maternal psychological factors like depression, anxiety and stress have been associated with infant fussiness or colic. However, little research exists on whether positive factors such as social support and the happiness of the mother-partner relationship are associated with lower rates of infant fussiness or colic. OBJECTIVES: We investigated the association between infant colic and three types of maternal support: general maternal social support (during pregnancy and post partum), the happiness of the mother-partner relationship (during pregnancy and post partum) and partner involvement in caring for the newborn...
March 7, 2017: Child: Care, Health and Development
https://www.readbyqxmd.com/read/28161387/intranasal-oxytocin-but-not-vasopressin-augments-neural-responses-to-toddlers-in-human-fathers
#16
Ting Li, Xu Chen, Jennifer Mascaro, Ebrahim Haroon, James K Rilling
This study investigates paternal brain function with the hope of better understanding the neural basis for variation in caregiving involvement among men. The neuropeptides oxytocin (OT) and vasopressin (AVP) are implicated in paternal caregiving in humans and other species. In a double-blind, placebo-controlled, within-subject pharmaco-functional MRI experiment, we randomized 30 fathers of 1-2year old children to receive either 24IU intranasal OT before one scan and placebo before the other scan (n=15) or 20IU intranasal AVP before one scan and placebo before the other scan (n=15)...
February 1, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28088194/testing-a-cognitive-model-to-predict-posttraumatic-stress-disorder-following-childbirth
#17
Lydia King, Kirstie McKenzie-McHarg, Antje Horsch
BACKGROUND: One third of women describes their childbirth as traumatic and between 0.8 and 6.9% goes on to develop posttraumatic stress disorder (PTSD). The cognitive model of PTSD has been shown to be applicable to a range of trauma samples. However, childbirth is qualitatively different to other trauma types and special consideration needs to be taken when applying it to this population. Previous studies have investigated some cognitive variables in isolation but no study has so far looked at all the key processes described in the cognitive model...
January 14, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28065954/postpartum-depression-and-associated-factors-after-emergency-peripartum-hysterectomy
#18
Mehmet Baki Senturk, Yusuf Cakmak, Ahmet Ozalp
OBJECTIVE: To investigate post-partum depression after emergency peripartum hysterectomy and associated factors. METHODS: This cross-sectional controlled study was conducted at Batman Gynaecology and Paediatric Diseases Hospital, Batman, Turkey, between June 15 and July 23, 2015, and comprised cases of patients with peripartum hysterectomy and of those who had experienced surgical procedures other than hysterectomy (hypogastric artery ligation and/or B-Lynch suture)...
January 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28012571/perinatal-nutrition-interventions-and-post-partum-depressive-symptoms
#19
REVIEW
Jacqueline F Gould, Karen Best, Maria Makrides
BACKGROUND: Postpartum depression (PPD) is the most prevalent mood disorder associated with childbirth. No single cause of PPD has been identified, however the increased risk of nutritional deficiencies incurred through the high nutritional requirements of pregnancy may play a role in the pathology of depressive symptoms. Three nutritional interventions have drawn particular interest as possible non-invasive and cost-effective prevention and/or treatment strategies for PPD; omega-3 (n-3) long chain polyunsaturated fatty acids (LCPUFA), vitamin D and overall diet...
December 18, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27996986/-effectiveness-of-a-postnatal-psychological-treatment-for-women-who-had-screened-positive-for-depression
#20
Fiorino Mirabella, Paolo Michielin, Daniele Piacentini, Franco Veltro, Gina Barbano, Marina Cattaneo, Gabriella Palumbo, Antonella Gigantesco
AIM: This study evaluates the effectiveness of a psychological intervention based on a brief cognitive behavioural and psycho-educational treatment for women suffering from post partum depression. METHOD: The sample was recruited within a programme of screening and early intervention for post partum depression risk. 1558 women were screened between the 6th and 12th week after birth. 110 (7.1%) of them resulted positive to the Edinburgh Postnatal Depression Scale (score ≥12) and 81 accepted a thorough clinical diagnostic examination through the administration of the Mini International Neuropsychiatric Interview and the self-assessment instruments Beck Depression Inventory, State-Trait Anxiety Inventory, Psychological Well-being Scales, Short-Form Health Survey and Positivity Scale...
November 2016: Rivista di Psichiatria
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