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Gamma knife radiation

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https://www.readbyqxmd.com/read/28319282/stereotactic-radiosurgery-for-essential-tremor-retrospective-analysis-of-a-19-year-experience
#1
Ajay Niranjan, Sudesh S Raju, Ali Kooshkabadi, Edward Monaco, John C Flickinger, L Dade Lunsford
BACKGROUND: Essential Tremor (ET) is a common movement disorder that can be disabling. Initial treatment is in the form of medical therapies. Patients with medically refractory ET seek surgical intervention which include radiofrequency thalamotomy, deep brain stimulation, and radiosurgical thalamotomy. Radiosurgical thalamotomy is a minimally invasive surgical option which is especially valuable for elderly and high surgical risk patients. OBJECTIVE: The purpose of this study was to retrospectively analyze the outcomes of stereotactic radiosurgery for patients suffering from medically refractory essential tremor...
March 20, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28258282/evaluation-of-auditory-pathways-using-dti-in-patients-treated-with-gamma-knife-radiosurgery-for-acoustic-neuroma-a%C3%A2-preliminary-report
#2
Serpil Kurtcan, Mustafa Aziz Hatiboglu, Alpay Alkan, Huseyin Toprak, Mehmet Hakan Seyithanoglu, Ayse Aralasmak, Bahar Atasoy, Omer Uysal
PURPOSE: We aimed to evaluate the change in bilateral auditory pathways using diffusion tensor imaging (DTI) after gamma knife radiosurgery (GKR) and to determine the relationship between the radiosurgical treatment variables and DTI findings. METHODS: In this study 13 patients with unilateral acoustic neuroma and 11 controls underwent routine magnetic resonance imaging (MRI) and DTI. The apparent diffusion coefficient (ADC) and fractional anisotropy (FA) were measured from the bilateral auditory pathways in all individuals before and after GKR...
March 3, 2017: Clinical Neuroradiology
https://www.readbyqxmd.com/read/28217873/radiosurgery-for-arteriovenous-malformations-and-the-impact-on-headaches
#3
Greg Bowden, Jonathon Cavaleri, Hideyuki Kano, Edward Monaco, Ajay Niranjan, John Flickinger, L Dade Lunsford
BACKGROUND: Arteriovenous malformations (AVMs) can underlie many diverse neurological signs and symptoms. Headaches are a common presentation that can have a significant impact on quality of life. OBJECTIVE: The authors investigated Gamma Knife(®) stereotactic radiosurgery (SRS) outcomes in patients with AVMs and associated headaches. METHODS: This retrospective study analyzed 102 patients with AVMs who underwent SRS between 1995 and 2013...
February 20, 2017: Headache
https://www.readbyqxmd.com/read/28168125/role-of-gamma-knife%C3%A2-radiosurgery-for-the-treatment-of-brain-metastases-from-gynecological-cancers
#4
Andrew Keller, Rahim Ismail, Peter S Potrebko, Julie Pepe, Meiling Wu, Kunal Saigal, Matthew Biagioli, Ravi Shridhar, Robert Holloway, Melvin Field, Nikhil G Rao
OBJECTIVE: Gamma Knife(®) (GK) (Elekta Instruments, Stockholm, Sweden) radiosurgery is well established for treatment of brain metastases. There are limited data on patients treated with GK from gynecological cancers. The authors sought to determine the effectiveness of the GK in patients with brain metastases from gynecological cancers. METHODS: An IRB-approved database was queried for patients with gynecologic cancers treated with GK between June 1996 and May 2016...
December 31, 2016: Curēus
https://www.readbyqxmd.com/read/28129632/analysis-the-causes-of-radiosurgical-failure-in-intracranial-meningiomas-treated-with-radiosurgery
#5
Moinay Kim, Young Hyun Cho, Jeong Hoon Kim, Chang Jin Kim, Do Hoon Kwon
OBJECTIVES: Surgical resection is a primary indication for intracranial meningioma. Radiosurgery is also an excellent treatment modality for postoperative residual tumors, or tumors in high-risk locations, such as the skull base. Despite multimodality treatments, there are some cases in which radiosurgery fails and surgical resection or re-radiosurgery is required. However, there has not been a comprehensive study focusing on the causes of secondary treatment for local recurrence or a new mass that develops outside the target area after radiosurgery...
March 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28120074/management-of-cerebral-radiation-necrosis-a-retrospective-study-of-12-patients
#6
Chenlong Liao, Massimiliano Visocchi, Wenchuan Zhang, Min Yang, Wenxiang Zhong, Pengfei Liu
BACKGROUND: Cerebral radiation necrosis (RN) is a severe complication of radiotherapy for cerebral pathologies. This study discusses the radiographic and pathological features of 12 patients with RN and investigates the management strategy. METHODS: Eleven patients with brain tumors, and one with cerebral cavernous angioma, treated by surgical resection or Gamma Knife alone before radiotherapy developed RN during follow-up. Surgical resection for the cerebral RN was performed in nine patients, and the other three patients received medical treatment...
2017: Acta Neurochirurgica. Supplement
https://www.readbyqxmd.com/read/28106495/comparison-of-prognostic-indices-in-patients-who-undergo-melanoma-brain-metastasis-radiosurgery
#7
Hideyuki Kano, Alejandro Morales-Restrepo, Aditya Iyer, Gregory M Weiner, Seyed H Mousavi, John M Kirkwood, Ahmad A Tarhini, John C Flickinger, L Dade Lunsford
OBJECTIVE The goal of this study was to use 4 prognostic indices to compare survival times of patients who underwent Gamma Knife stereotactic radiosurgery (SRS) to treat melanoma brain metastases. METHODS The authors analyzed 422 consecutive patients (1440 brain metastases) who underwent Gamma Knife SRS. The median total brain tumor volume was 4.7 cm(3) (range 0.3-69.3 cm(3)), and the median number of metastases was 2 (range 1-32). One hundred thirty-two patients underwent whole-brain radiation therapy. Survival times were compared using recursive partitioning analysis (RPA), the Score Index for Radiosurgery (SIR), the Basic Score for Brain Metastases (BSBM), and the Diagnosis-Specific Graded Prognostic Assessment (DS-GPA)...
January 20, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28089836/delayed-csf-rhinorrhea-after-gamma-knife-radiosurgery-with-or-without-preceding-transsphenoidal-resection-for-pituitary-pathology
#8
Avital Perry, Christopher S Graffeo, William R Copeland, Kathryn M Van Abel, Matthew L Carlson, Bruce E Pollock, Michael J Link
BACKGROUND: Skull base cerebrospinal fluid (CSF) leak after gamma knife radiosurgery (GKRS) is a very rare complication. In patients who were treated with both GKRS and transsphenoidal resection (TSR) for pituitary lesions, early CSF leak occurs at a comparable rate to the general TSR population (4%). Delayed CSF leak occurring more than a year after TSR, GKRS, or dual therapy, is exceedingly rare. METHODS: Retrospective chart review and review of the literature RESULTS: We present two cases of delayed CSF leak following GKRS to treat pituitary adenoma...
January 9, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28081463/analysis-of-the-results-of-recurrent-intracranial-meningiomas-treated-with-re-radiosurgery
#9
Moinay Kim, Do Hee Lee, Hyun Jung Kim Rn, Young Hyun Cho, Jeong Hoon Kim, Do Hoon Kwon
OBJECTS: Meningioma is the most common intracranial neoplasm, comprising approximately 30% of all primary intracranial tumors (Claus et al., 2005) [1]. Treatment options include observation, microsurgical resection, stereotactic radiosurgery (SRS), and whole brain radiation therapy (WBRT). Gamma knife radiosurgery (GKRS) is a very effective treatment for intracranial meningiomas; previous studies showed the tumor control rate at 5-10 years of follow-up as 84.3%-100% in all cases (Feigl et al...
February 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28078405/-radiosurgery-and-fractionated-stereotactic-radiotherapy-of-vestibular-schwannoma
#10
K Hamm, H-U Herold, G Surber, S Rosahl
Management of vestibular schwannoma (VS) should always be interdisciplinary and results better than the natural course. Particularly in small VS, either microsurgical resection or radiosurgery (RS) can be employed. RS is a special method (initially only possible stereotactically) for delivering high-precision radiation from many directions to the target point (the isocenter) in a single high dose. With the development of three different systems-Gamma Knife (Elekta, Stockholm, Sweden), special linear accelerators, and CyberKnife (Accuray, Sunnyvale, CA, USA)-the options were extended to 1-5 fractions for RS and multisession RS (msRS), and to up to 6 weeks of conventional fractionation as stereotactic radiotherapy (SRT)...
January 11, 2017: HNO
https://www.readbyqxmd.com/read/28048479/we-ab-207b-01-dose-tolerance-for-sbrt-sabr
#11
J Grimm
PURPOSE: Stereotactic body radiation therapy (SBRT) / stereotactic ablative body radiotherapy (SABR) is gaining popularity, but quantitative dose tolerance has still been lacking. To improve this, the April 2016 issue of Seminars in Radiation Oncology will have normal tissue complication probability (NTCP) models for 10 critical structures: optic pathway, cochlea, oral mucosa, esophagus, chestwall, aorta, bronchi, duodenum, small bowel, and spinal cord. METHODS: The project included more than 1500 treatments in 1-5 fractions using CyberKnife, Gamma Knife, or LINAC, with 60 authors from 15 institutions...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048017/tu-d-207b-01-a-prediction-model-for-distinguishing-radiation-necrosis-from-tumor-progression-after-gamma-knife-radiosurgery-based-on-radiomics-features-from-mr-images
#12
Z Zhang, A Ho, X Wang, P Brown, N Guha-Thakurta, S Ferguson, X Fave, L Zhang, D Mackin, L Court, J Li, J Yang
PURPOSE: To develop and validate a prediction model using radiomics features extracted from MR images to distinguish radiation necrosis from tumor progression for brain metastases treated with Gamma knife radiosurgery. METHODS: The images used to develop the model were T1 post-contrast MR scans from 71 patients who had had pathologic confirmation of necrosis or progression; 1 lesion was identified per patient (17 necrosis and 54 progression). Radiomics features were extracted from 2 images at 2 time points per patient, both obtained prior to resection...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047718/su-f-t-445-effect-of-triaxial-cables-and-microdetectors-in-small-field-dosimetry
#13
I Das, A Andersen
PURPOSE: Advances in radiation treatment especially with smaller fields used in SRS, Gamma knife, Tomotherapy, Cyberknife, and IMRT, require a high degree of precision especially with microdetectors for small field dosimetry (Das et al, Med Ph, 35, 206, 2008; Alfonso et al, Med Phys, 35, 5179, 2008). Due to small signal, the triaxial cable becomes critical in terms of signal to noise ratio (SNR) which is studied with microdetectors. METHODS: Six high quality triaxial cables, 9...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047644/th-cd-bra-09-towards-absolute-dose-measurement-in-mri-linac-and-gamma-knife-design-and-construction-of-an-mr-compatible-water-calorimeter
#14
N Entezari, J Renaud, G Peterson, A Sarfehnia
PURPOSE: The purpose of this work is to design and optimize a portable Water Calorimeter (WC) for use in a commercial MRI-linac and Gamma-knife in addition to conventional radiotherapy linacs. Water calorimeters determine absorbed dose to water at a point by measuring radiation-induced temperature rise of the volume (the two are related by the medium specific heat capacity). In this formalism, one important correction factor is heat transfer correction k_ht. It compensates for heat gain/loss due to conductive and convective effects, and is numerically calculated as ratio of temperature rise in the absence of heat loss to that in the presence of heat loss...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047299/su-f-t-252-an-investigation-of-gamma-knife-frame-definition-error-when-using-a-pre-planning-workflow
#15
P Johnson
PURPOSE: To determine causal factors related to high frame definition error when treating GK patients using a pre-planning workflow. METHODS: 160 cases were retrospectively reviewed. All patients received treatment using a pre-planning workflow whereby stereotactic coordinates are determined from a CT scan acquired after framing using a fiducial box. The planning software automatically detects the fiducials and compares their location to expected values based on the rigid design of the fiducial system...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047156/su-f-t-593-technical-treatment-accuracy-in-a-clinic-of-fractionated-stereotactic-radiosurgery
#16
R Bisht, S Kale, G Natanasabapathi, M Singh, D Agarwal, G Rath, P Julka, P Kumar, S Thulkar, A Garg, B Sharma
PURPOSE: The purpose of this study is to estimate technical treatment accuracy in fractionated stereotactic radiosurgery (fSRS) using extend system (ES) of Gamma Knife (GK). METHODS: The fSRS with GK relies on a patient specific re-locatable immobilization system. The reference treatment position is estimated using a digital probe and a repositioning check tool (RCT). The "calibration values" of RCT apertures were compared with measured values on RCT-QA tool to evaluate the standard error (SE) associated with RCT measurements...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046289/su-f-j-160-clinical-evaluation-of-targeting-accuracy-in-radiosurgery-using-tractography
#17
R Juh, T Suh, J Han, C Kim, C Oh
PURPOSE: Focal radiosurgery is a common treatment modality for trigeminal neuralgia (TN), a neuropathic facial pain condition. Assessment of treatment effectiveness is primarily clinical, given the paucity of investigational tools to assess trigeminal nerve changes. The efficiency of radiosurgery is related to its highly precise targeting. We assessed clinically the targeting accuracy of radiosurgery with Gamma knife. We hypothesized that trigeminal tractography provides more information than 2D-MR imaging, allowing detection of unique, focal changes in the target area after radiosurgery...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28044461/equivalence-of-cell-survival-data-for-radiation-dose-and-thermal-dose-in-ablative-treatments-analysis-applied-to-essential-tremor-thalamotomy-by-focussed-ultrasound-and-gamma-knife
#18
D Schlesinger, M Lee, G Ter Haar, B Sela, M Eames, J Snell, N Kassell, J Sheehan, J M Larner, J-F Aubry
Thermal dose and absorbed radiation dose have historically been difficult to compare because different biological mechanisms are at work. Thermal dose denatures proteins and the radiation dose causes DNA damage in order to achieve ablation. The purpose of this paper is to use the proportion of cell survival as a potential common unit by which to measure the biological effect of each procedure. Survival curves for both thermal and radiation doses have been extracted from previously published data for three different cell types...
January 31, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28017757/is-fractionated-gamma-knife-radiosurgery-a-safe-and-effective-treatment-approach-for-large-volume-10-cm-3-intracranial-meningiomas
#19
Moon-Soo Han, Woo-Youl Jang, Kyung-Sub Moon, Sa-Hoe Lim, In-Young Kim, Tae-Young Jung, Shin Jung
BACKGROUND: Even with great advances in surgery and improved clinical outcome, morbidity and mortality are still high for large-volume intracranial meningiomas (MNGs). Recently, Gamma Knife radiosurgery (GKS) has proven to be a safe and effective treatment for many patients with intracranial MNGs. However, single-session GKS may increase the risk of radiation-induced toxicity for large MNGs. Recently, fractionated GKS (FGKS) has been performed for an increasing number of patients with surgically high-risk and large intracranial tumors...
March 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28003946/dosimetric-study-of-automatic-brain-metastases-planning-in-comparison-with-conventional-multi-isocenter-dynamic-conformal-arc-therapy-and-gamma-knife-radiosurgery-for-multiple-brain-metastases
#20
Yoshimasa Mori, Naoki Kaneda, Masahiro Hagiwara, Tuneo Ishiguchi
OBJECTIVE: The efficacy of stereotactic radiosurgery (SRS) using Gamma Knife (GK) (Elekta, Tokyo) is well known. Recently, Automatic Brain Metastases Planning (ABMP) Element (BrainLAB, Tokyo) for a LINAC-based radiation system was commercially released. It covers multiple off-isocenter targets simultaneously inside a multi-leaf collimator field and enables SRS / stereotactic radiotherapy (SRT) with a single group of LINAC-based dynamic conformal multi-arcs (DCA) for multiple brain metastases...
November 15, 2016: Curēus
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