keyword
https://read.qxmd.com/read/38517433/physical-dose-validation-of-dynamic-treatment-for-gamma-knife-radiosurgery
#1
JOURNAL ARTICLE
Benjamin Z Tham, Dionne M Aleman, Robert K Heaton, Håkan Nordström, Catherine Coolens
BACKGROUND: Dynamic treatment in Gamma Knife (GK) radiosurgery systems delivers radiation continuously with couch movement, as opposed to stationary step-and-shoot treatment where radiation is paused when moving between isocenters. Previous studies have shown the potential for dynamic GK treatment to give faster treatment times and improved dose conformity and homogeneity. However, these studies focused only on computational simulations and lack physical validation. PURPOSE: This study aims conduct dynamic treatment dosimetric validation with physical experimental measurements...
March 22, 2024: Medical Physics
https://read.qxmd.com/read/38514580/upfront-stereotactic-radiosurgery-versus-adjuvant-radiosurgery-for-parasagittal-and-parafalcine-meningiomas-a-systematic-review-and-meta-analysis
#2
REVIEW
Fernando De Nigris Vasconcellos, Pavel Pichardo-Rojas, Augusto Muller Fieldler, Elad Mashiach, Brandon Santhumayor, Jowah Gorbachev, Hayes Fountain, Josh Bandopadhay, Timoteo Almeida, Jason Sheehan
Parafalcine and parasagittal (PFPS) are common locations for meningiomas. Surgical resection for these tumors, the first-line treatment, poses challenges due to their proximity to critical structures. This systematic review investigates the use of stereotactic radiosurgery (SRS) as a treatment for PFPS meningiomas, aiming to elucidate its safety and efficacy. The review adhered to PRISMA guidelines. Searches were conducted on MEDLINE, Embase, and Cochrane. Inclusion criteria involved studies on SRS for PFPS meningiomas, reporting procedure outcomes and complications...
March 22, 2024: Neurosurgical Review
https://read.qxmd.com/read/38499993/terminally-differentiated-cytotoxic-cd4-t-cells-were-clonally-expanded-in-the-brain-lesion-of-radiation-induced-brain-injury
#3
JOURNAL ARTICLE
Xueying Ma, You Zuo, Xia Hu, Sitai Chen, Ke Zhong, Ruiqi Xue, Shushu Gui, Kejia Liu, Shaojian Li, Xiaoqiu Zhu, Jingwen Yang, Zhenhong Deng, Xiaolu Liu, Yongteng Xu, Sheng Liu, Zhongshan Shi, Meijuan Zhou, Yamei Tang
BACKGROUND: Accumulating evidence supports the involvement of adaptive immunity in the development of radiation-induced brain injury (RIBI). Our previous work has emphasized the cytotoxic function of CD8+ T cells in RIBI. In this study, we aimed to investigate the presence and potential roles of cytotoxic CD4+ T cells (CD4+ CTLs) in RIBI to gain a more comprehensive understanding of adaptive immunity in this context. MAIN TEXT: Utilizing single-cell RNA sequencing (scRNA-seq), we analyzed 3934 CD4+ T cells from the brain lesions of four RIBI patients and identified six subclusters within this population...
March 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38484375/-stereotactic-radiosurgery-of-brain-tumors
#4
JOURNAL ARTICLE
Imre Fedorcsák, András Bajcsay, Levente Jánváry
Stereotactic radiosurgery is today a well-established treatment modality for various intracranial pathologies. The principle of high dose focused intracranial radiation guided by stereotactic technique ("Gamma Knife") was introduced by the Swedish neurosurgeon Prof. Lars Leksell in 1968. After the advent of CT and later MR imaging, stereotactic radiosurgery evolved rapidly regarding indications, and new technical solutions made it possible for linear accelerator systems to perform radiosurgery. A huge number of patients are treated yearly worldwide with this technology...
March 14, 2024: Magyar Onkologia
https://read.qxmd.com/read/38466497/long-term-geometric-quality-assurance-of-radiation-focal-point-and-cone-beam-computed-tomography-for-gamma-knife-radiosurgery-system
#5
JOURNAL ARTICLE
Shingo Ohira, Toshikazu Imae, Masanari Minamitani, Atsuto Katano, Atsushi Aoki, Takeshi Ohta, Motoyuki Umekawa, Yuki Shinya, Hirotaka Hasegawa, Teiji Nishio, Masahiko Koizumi, Hideomi Yamashita, Nobuhito Saito, Keiichi Nakagawa
To investigate the geometric accuracy of the radiation focal point (RFP) and cone-beam computed tomography (CBCT) over long-term periods for the ICON Leksell Gamma Knife radiosurgery system. This phantom study utilized the ICON quality assurance tool plus, and the phantom was manually set on the patient position system before the implementation of treatment for patients. The deviation of the RFP position from the unit center point (UCP) and the positions of the four ball bearings (BBs) in the CBCT from the reference position were automatically analyzed...
March 11, 2024: Radiological Physics and Technology
https://read.qxmd.com/read/38455249/stereotactic-radiosurgery-for-idiopathic-glossopharyngeal-neuralgia-a-systematic-review
#6
REVIEW
Timoleon Siempis, Roberta Rehder, Spyridon Voulgaris, George A Alexiou
BACKGROUND: Stereotactic radiosurgery (SRS) has recently gained space as an accepted non-invasive alternative treatment option for drug resistant Glossopharyngeal neuralgia (GPN). The purpose of this systematic review was to provide an overview of the outcomes of SRS treatment in patients with GPN. METHODS: A literature review until March 2023 was performed. Data about patient's demographics, complications and recurrence rates, additional treatment post procedure as well as pain outcomes in the short and long term were collected...
April 2024: World neurosurgery: X
https://read.qxmd.com/read/38422744/brain-metastases-from-renal-cell-carcinoma-effects-of-novel-systemic-agents-on-brain-metastasis-outcomes
#7
JOURNAL ARTICLE
Hadley W Ressler, Christina K Cramer, Scott Isom, Michael McCormack, Jimmy Ruiz, Fei Xing, Wencheng Li, Christopher T Whitlow, Jaclyn J White, Adrian W Laxton, Stephen B Tatter, Michael D Chan
OBJECTIVE: The objective of this study was to examine survival outcomes in 136 patients with renal cell carcinoma with metastases to the brain who were treated with radiation combined with immunotherapy or tyrosine kinase inhibitor compared to those who were treated with radiation therapy alone. METHODS: The Wake Forest Gamma Knife prospective database was searched for all patients with renal cell carcinoma brain metastases. Outcome measurements included overall survival, determined via the Kaplan-Meier Method, and cumulative incidence of local and distant failure, determined using the Fine Gray competing risks analysis with death as a competing risk for the 136 patients included...
February 24, 2024: Clinical Neurology and Neurosurgery
https://read.qxmd.com/read/38399534/assessment-of-radiation-dosage-to-the-hippocampi-during-treatment-of-multiple-brain-metastases-using-gamma-knife-therapy
#8
JOURNAL ARTICLE
Maciej Laskowski, Bartłomiej Błaszczyk, Marcin Setlak, Maciej Kuca, Arkadiusz Lech, Kamil Kłos, Adam Rudnik
Background and Objectives: Brain metastases (BMs) pose significant clinical challenges in systemic cancer patients. They often cause symptoms related to brain compression and are typically managed with multimodal therapies, such as surgery, chemotherapy, whole brain radiotherapy (WBRT), and stereotactic radiosurgery (SRS). With modern oncology treatments prolonging survival, concerns about the neurocognitive side effects of BM treatments are growing. WBRT, though widely used for multiple BMs, has recognized neurocognitive toxicity...
January 31, 2024: Medicina
https://read.qxmd.com/read/38388908/is-two-staged-gamma-knife-surgery-a-reasonable-management-option-for-very-large-cerebellar-metastases-a-case-series-of-three-patients
#9
JOURNAL ARTICLE
Yu Tung Lo, Bengt Karlsson, Andrea Wong, Balamurugan A Vellayappan, Tseng Tsai Yeo, Vincent Diong Weng Nga
OBJECTIVE: Two-staged gamma knife surgery (GKS) is a method that may extend the upper tumor volume limit for using GKS in the management of brain metastases. However, the safety of treating very large posterior fossa lesions with this technique has not been well demonstrated. Therefore, we analyzed our experience in treating cerebellar metastases larger than 12 cm3 with two-staged GKS. METHODS: Four consecutive patients harboring 12 to 30 cm3 cerebellar metastases scheduled two-staged GKS were included in the study, and all but one patient completed the treatment...
February 22, 2024: Acta Neurochirurgica
https://read.qxmd.com/read/38387112/efficacy-of-hypofractionated-gamma-knife-radiosurgery-in-treating-surgical-beds-of-metastatic-brain-tumors
#10
JOURNAL ARTICLE
Yavuz Samanci, Mehmet Ali Tepebasili, Gokce Deniz Ardor, Ali Haluk Duzkalir, M Orbay Askeroglu, Selcuk Peker
OBJECTIVE: Surgery alone for metastatic brain tumors (METs) often results in local recurrence due to microscopic residual tumor tissue. While stereotactic radiosurgery (SRS) is commonly used post-surgery, hypofractionation may be required for large surgical beds. This study evaluated the efficacy and safety of hypofractionated Gamma Knife radiosurgery (hf-GKRS) for the first time as a post-operative adjuvant therapy. METHODS: This retrospective study involved 24 patients (28 surgical beds) who underwent hf-GKRS within four weeks after surgery...
February 21, 2024: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://read.qxmd.com/read/38385643/long-term-outcomes-of-gamma-knife-radiosurgery-in-treating-glossopharyngeal-neuralgia
#11
JOURNAL ARTICLE
Yavuz Samanci, Elif Mürdün, Mahmut Çil, Ali Haluk Düzkalir, Mehmet Orbay Askeroglu, Selcuk Peker
Glossopharyngeal neuralgia (GPN) is an unusual disorder causing severe, brief pain episodes in the areas supplied by the glossopharyngeal nerve. Initial treatment involves medications like carbamazepine, but if these are ineffective or cause side effects, interventional pain management techniques or surgery may be considered. Gamma Knife radiosurgery is becoming popular in managing GPN due to its lower risk of complications than surgical interventions like microvascular decompression or rhizotomy. In this retrospective case series, we examined the outcomes of Gamma Knife radiosurgery in eight patients with GPN...
February 22, 2024: Headache
https://read.qxmd.com/read/38374924/esophageal-adenocarcinoma-presenting-as-an-isolated-brain-lesion-6-years-after-treatment
#12
Jeevan Murthy, John Moise, Kaitlyn Mi, Sonikpreet Aulakh
Intracranial metastasis is a rare sequela of esophageal adenocarcinoma (EAC), typically presenting within the first 2 years after primary tumor detection. Our patient is a 72-year-old man diagnosed with an EAC in 2015 and presented with recurrence of a distant solitary brain lesion approximately 6 years after the initial diagnosis. Histological diagnosis was confirmed as EAC with all relevant indicators. In addition, we used genomic profiling to detect biomarkers that can be useful in the future for therapies...
February 2024: ACG Case Reports Journal
https://read.qxmd.com/read/38372777/successful-surgical-treatment-of-oculomotor-palsy-due-to-schwannoma-of-the-cavernous-sinus-in-a-7-year-old-girl-a-case-report
#13
JOURNAL ARTICLE
Noboru Ishino, Kenichi Ishibashi, Noritsugu Kunihiro, Kazuhiro Yamanaka, Takeshi Inoue, Takeo Goto
Oculomotor nerve schwannoma in children not associated with neurofibromatosis is a rare disease, with 26 pediatric cases reported so far. There is no established treatment plan. A 7-year-old girl presented with oculomotor nerve palsy. Surgical reduction of the tumor combined with postoperative gamma knife surgery preserved the oculomotor nerve, improved oculomotor nerve function, and achieved tumor control during the observation period of 20 months. The combination of partial surgical resection and gamma knife surgery as a treatment strategy for oculomotor nerve schwannoma resulted in a good outcome...
February 19, 2024: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://read.qxmd.com/read/38363336/investigation-of-the-effects-of-gamma-knife-radiosurgery-on-optic-pathways-using-diffusion-tensor-mri-within-the-first-year-after-treatment
#14
JOURNAL ARTICLE
Merve Yazol, Halil Ozer, Berrak Barutcu Asfuroglu, Gökhan Kurt, Ömer Hakan Emmez, Ali Yusuf Öner
PURPOSE: To investigate the radiation-induced effects of Gamma Knife radiosurgery (GKRS) for sellar-parasellar tumors on optic pathways using DTI parameters within the first year after treatment. METHODS: Twenty-five patients with sellar-parasellar tumors underwent MRI before and 3 months after GKRS, including T1WI, DTI, T2WI. Moreover, 21 patients underwent follow-up DTI 6-8 months after radiosurgery. ROIs were set on optic nerves, optic radiations, and control localizations; DTI parameters for each were calculated...
February 16, 2024: Neuroradiology
https://read.qxmd.com/read/38360207/adjuvant-stereotactic-radiosurgery-for-clear-cell-meningiomas
#15
JOURNAL ARTICLE
Zhishuo Wei, Shalini G Jose, Prateek Agarwal, Stephen Worrell, Scott Kulich, Jack K Donohue, Hansen Deng, Costas G Hadjipanayis, Ajay Niranjan, L Dade Lunsford
OBJECTIVE: Clear cell meningiomas (CCM) are an uncommon meningioma subtype marked by aggressive growth and high rates of recurrence despite initial resection. The present study evaluates the adjuvant benefit of stereotactic radiosurgery (SRS) for residual or recurrent tumors. METHODS: After review of our prospectively maintained data base, we identified 6 patients (3 female) with histologically confirmed Grade 2 CCMs. The median age of the patients at the time of SRS was 45 years...
February 13, 2024: World Neurosurgery
https://read.qxmd.com/read/38348957/hearing-preservation-after-stereotactic-radiosurgery-for-sporadic-intracanalicular-vestibular-schwannomas-classified-as-koos-grade-1
#16
JOURNAL ARTICLE
Ho Kang, So Young Ji, Chae-Yong Kim, Ja-Won Koo, Jae-Jin Song, Byung Yoon Choi, Kihwan Hwang, Jung Ho Han
INTRODUCTION: The mechanism of hearing loss following stereotactic radiosurgery (SRS) for vestibular schwannomas (VSs) remains unclear. There is conflicting evidence regarding cochlear nerve damage by transient volume expansion of VSs after radiosurgery and radiation-induced cochlear damage. This study aimed to investigate whether there is a specific patient population that can achieve definite hearing preservation after SRS for VSs. METHODS: A total of 37 consecutive patients with sporadic unilateral intracanalicular VSs and serviceable hearing (Gardner-Roberson [G-R] class I or II) were treated with SRS from 2009 to 2023...
January 2024: Cancer Medicine
https://read.qxmd.com/read/38342737/stereotatic-radiosurgery-for-the-treatment-of-motor-symptoms-in-parkinson-s-disease-a-systematic-review
#17
REVIEW
Gabriela Magalhães Pereira, Nayron Medeiros Soares, Carlos Roberto de Mello Rieder, Thatiane Alves Pianoschi Alva
BACKGROUND: Stereotaxic Radiosurgery (SRS) is a non-invasive lesioning technique for movement disorders when patients cannot undergo DBS due to medical comorbidities. OBJECTIVE: To describe and summarize the literature on SRS's application and physical parameters for Parkinson's disease (PD) motor symptoms. METHODS: The MEDLINE/PUBMED and EMBASE databases were searched in July 2022 following the PRISMA guideline. Two independent reviewers screened data from 425 articles...
February 10, 2024: Journal of Medical Imaging and Radiation Sciences
https://read.qxmd.com/read/38317493/central-nervous-system-dissemination-of-solitary-sporadic-supratentorial-hemangioblastoma-a-case-report-and-literature-review
#18
Seong-Chan Jung, In-Young Kim, Shin Jung, Tae-Young Jung, Kyung-Sub Moon, Yeong-Jin Kim, Sue-Jee Park, Kyung-Hwa Lee
We report a patient with whole neuroaxis dissemination of a sporadic supratentorial hemangioblastoma (HB) for more than 15 years. A 68-year-old female patient presented with severe radiating pain in the right leg. Gadolinium-enhanced lumbar spine MRI showed an intradural mass (2.5 cm in diameter) at the L4 level. The patient had been severely disabled for 22 years after a previous intraventricular brain tumor resection. At that time, the diagnosis was angioblastic meningioma, which was thought to be incorrect...
January 2024: Brain Tumor Research and Treatment
https://read.qxmd.com/read/38313911/extensive-intracranial-meningioma-with-dehiscences-a-case-report
#19
Corneliu Toader, Luca-Andrei Glavan, Razvan-Adrian Covache-Busuioc, Bogdan-Gabriel Bratu, Horia-Petre Costin, Antonio-Daniel Corlatescu, Alexandru Vladimir Ciurea
This case report elucidates the clinical and surgical journey of a 62-year-old patient with a history of multiple comorbidities including a severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infection, presenting with temporospatial disorientation, bradypsychia, and bradyphasia, without motor deficits, diagnosed with sarcomatous meningioma and skull lysis. Amidst the complexities of managing primary brain tumors, this report underscores the significance of thorough morphopathological examination, while considering patient demographics and tumor localization in assessing the nature of the neoplasm...
January 2024: Curēus
https://read.qxmd.com/read/38297028/dynamic-functional-changes-upon-thalamotomy-in-essential-tremor-depend-on-baseline-brain-morphometry
#20
JOURNAL ARTICLE
Thomas A W Bolton, Dimitri Van De Ville, Jean Régis, Tatiana Witjas, Nadine Girard, Marc Levivier, Constantin Tuleasca
Patients with drug-resistant essential tremor (ET) may undergo Gamma Knife stereotactic radiosurgical thalamotomy (SRS-T), where the ventro-intermediate nucleus of the thalamus (Vim) is lesioned by focused beams of gamma radiations to induce clinical improvement. Here, we studied SRS-T impacts on left Vim dynamic functional connectivity (dFC, n = 23 ET patients scanned before and 1 year after intervention), and on surface-based morphometric brain features (n = 34 patients, including those from dFC analysis)...
January 31, 2024: Scientific Reports
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