Xueying Ma, You Zuo, Xia Hu, Sitai Chen, Ke Zhong, Ruiqi Xue, Shushu Gui, Kejia Liu, Shaojian Li, Xiaoqiu Zhu, Jingwen Yang, Zhenhong Deng, Xiaolu Liu, Yongteng Xu, Sheng Liu, Zhongshan Shi, Meijuan Zhou, Yamei Tang
BACKGROUND: Accumulating evidence supports the involvement of adaptive immunity in the development of radiation-induced brain injury (RIBI). Our previous work has emphasized the cytotoxic function of CD8+ T cells in RIBI. In this study, we aimed to investigate the presence and potential roles of cytotoxic CD4+ T cells (CD4+ CTLs) in RIBI to gain a more comprehensive understanding of adaptive immunity in this context. MAIN TEXT: Utilizing single-cell RNA sequencing (scRNA-seq), we analyzed 3934 CD4+ T cells from the brain lesions of four RIBI patients and identified six subclusters within this population...
March 2024: CNS Neuroscience & Therapeutics