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https://www.readbyqxmd.com/read/29131131/gamma-knife-stereotactic-radiosurgery-for-the-treatment-of-primary-and-metastatic-ocular-malignancies
#1
Andrea L H Arnett, Margaret M Reynolds, Jose S Pulido, Ian F Parney, Nadia N Laack
BACKGROUND: Gamma knife radiosurgery (GKR) can be used for precise targeting of malignant lesions of the CNS when brachytherapy is not an appropriate option. OBJECTIVES: This study reports treatment technique, efficacy, and radiation-induced adverse effects in patients with primary and metastatic ocular lesions treated with Leksell GKR. METHODS: A retrospective, single-institution review was conducted of 28 patients with primary or metastatic ocular disease, treated from 2000 to 2014...
November 4, 2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29125412/stereotactic-radiosurgery-for-jugular-foramen-schwannomas-an-international-multicenter-study
#2
Hideyuki Kano, Antonio Meola, Huai-Che Yang, Wan-Yuo Guo, Roberto Martínez-Alvarez, Nuria Martínez-Moreno, Dusan Urgosik, Roman Liscak, Or Cohen-Inbar, Jason Sheehan, John Y K Lee, Mahmoud Abbassy, Gene H Barnett, David Mathieu, Douglas Kondziolka, L Dade Lunsford
OBJECTIVE For some jugular foramen schwannomas (JFSs), complete resection is possible but may be associated with significant morbidity. Stereotactic radiosurgery (SRS) is a minimally invasive alternative or adjunct to microsurgery for JFSs. The authors reviewed clinical and imaging outcomes of SRS for patients with these tumors. METHODS Nine participating centers of the International Gamma Knife Research Foundation identified 92 patients who underwent SRS between 1990 and 2013. Forty-one patients had prior subtotal microsurgical resection...
November 10, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29082599/failure-modes-and-effects-analysis-fmea-for-gamma-knife-radiosurgery
#3
Andy Yuanguang Xu, Jagdish Bhatnagar, Greg Bednarz, John Flickinger, Yoshio Arai, Jonet Vacsulka, Wenzheng Feng, Edward Monaco, Ajay Niranjan, L Dade Lunsford, M Saiful Huq
PURPOSE: Gamma Knife radiosurgery is a highly precise and accurate treatment technique for treating brain diseases with low risk of serious error that nevertheless could potentially be reduced. We applied the AAPM Task Group 100 recommended failure modes and effects analysis (FMEA) tool to develop a risk-based quality management program for Gamma Knife radiosurgery. METHODS: A team consisting of medical physicists, radiation oncologists, neurosurgeons, radiation safety officers, nurses, operating room technologists, and schedulers at our institution and an external physicist expert on Gamma Knife was formed for the FMEA study...
October 29, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29069961/factors-affecting-hearing-deterioration-in-vestibular-schwannoma-patients-treated-with-gamma-knife-radiosurgery-the-asan-medical-center-experience
#4
Marn Joon Park, Hong Ju Park, Jong Woo Chung, Do Heui Lee, Young Hyun Cho, Young Jun Choi, Joong Ho Ahn
OBJECTIVES: To investigate the changes in hearing and to determine factors predicting hearing deterioration in patients with vestibular schwannoma (VS) who undergo gamma knife radiosurgery (GKRS). DESIGN: A retrospective review of medical records in patients diagnosed with VS and initially treated with GKRS at a tertiary care medical center between 1995 and 2015 was performed. Tumor factors (location, volume), parameters related to irradiation to the tumor and cochlea, and distance between the tumor and cochlea were reviewed...
October 25, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29022157/radiosurgery-in-trochlear-and-abducens-nerve-schwannomas-case-series-and-systematic-review
#5
Iulia Peciu-Florianu, Constantin Tuleasca, Jean-Nicolas Comps, Luis Schiappacasse, Michele Zeverino, Roy Thomas Daniel, Marc Levivier
INTRODUCTION: Schwannomas involving the occulomotor cranial nerves  (CNs; III, IV and VI), can be disabling, due to the associated diplopia and decreased quality of life and are extremely rare. We evaluated the role of Gamma Knife surgery (GKS) in these cases. METHODS: Five patients with CN IV and VI schwannomas (three and two, respectively) were treated in Lausanne University Hospital between 2010 and 2015. Four benefitted from upfront GKS and one from a combined approach (planned subtotal resection followed by GKS), due to a large preoperative tumour volume (size, 3 × 2 × 2...
October 11, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29017157/impact-of-the-number-of-metastatic-tumors-treated-by-stereotactic-radiosurgery-on-the-dose-to-normal-brain-implications-for-brain-protection
#6
Charlotte Rivers, Marissa Tranquilli, Shefalika Prasad, Evan Winograd, Robert J Plunkett, Robert A Fenstermaker, Andrew J Fabiano, Matthew B Podgorsak, Dheerendra Prasad
PURPOSE/OBJECTIVES: The purpose of this study was to evaluate the effect of the number of brain lesions for which stereotactic radiosurgery (SRS) was performed on the dose volume relationships in normal brain. MATERIALS AND METHODS: Brain tissue was segmented using the patient's pre-SRS MRI. For each plan, the following data points were recorded: total brain volume, number of lesions treated, volume of brain receiving 8 Gy (V8), V10, V12, and V15. RESULTS: A total of 225 Gamma Knife® treatments were included in this retrospective analysis...
October 11, 2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/28992711/-treatment-of-pituitary-adenomas
#7
Jana Ježková, Josef Marek, Manuela Vaněčková
Pituitary adenomas are the most common tumours of the sellar region. A combination of neurosurgery, radiation and pharmacological approaches are applied for the treatment of pituitary adenomas. In certain cases, patient observation is another option. Neurosurgery is the first-choice treatment for acromegaly, Cushing´s disease and TSH secreting adenomas. Leksell gamma knife irradiation is used in the treatment of tumour residues. Until the effect of the irradiation is evident, pharmacological treatment must be administered...
2017: Casopís Lékar̆ů C̆eských
https://www.readbyqxmd.com/read/28983447/surgical-management-and-outcome-experience-of-53-cerebellopontine-angle-meningiomas
#8
Xiaosheng He, Weiping Liu, Yangang Wang, Jun Zhang, Buqing Liang, Jason H Huang
Background Meningiomas follow schwannomas as the second most common cerebellopontine angle (CPA) tumors. We investigate the diagnosis, management, and prognosis of this disease. Methods We reviewed the cases with the CPA meningiomas in our institution in Shaanxi, China from January 2012 to December 2015. Charts were retrospectively examined and patients were divided into two groups: 1) surgical treatment with a retrosigmoid approach for tumor resection and 2) stereotactic radiosurgery treatment only. Patients were followed up and outpatient records were also reviewed...
August 3, 2017: Curēus
https://www.readbyqxmd.com/read/28975062/patient-specific-fetal-dose-determination-for-multi-target-gamma-knife-radiosurgery-computational-model-and-case-report
#9
Anna K Paulsson, Steve Braunstein, Justin Phillips, Philip V Theodosopoulos, Michael McDermott, Patricia K Sneed, Lijun Ma
A 42-year-old woman at 29 weeks gestation via in vitro fertilization who presented with eight metastatic brain lesions received Gamma Knife stereotactic radiosurgery (GKSRS) at our institution. In this study, we report our clinical experience and a general procedure of determining the fetal dose from patient-specific treatment plans and we describe quality assurance measurements to guide the safe practice of multi-target GKSRS of pregnant patients. To estimate fetal dose pre-treatment, peripheral dose-to-focal dose ratios (PFRs) were measured in a phantom at the distance approximating the fundus of uterus...
July 31, 2017: Curēus
https://www.readbyqxmd.com/read/28949989/in-vivo-imaging-of-endothelial-cell-adhesion-molecule-expression-after-radiosurgery-in-an-animal-model-of-arteriovenous-malformation
#10
Newsha Raoufi-Rad, Lucinda S McRobb, Vivienne S Lee, David Bervini, Michael Grace, Jaysree Ukath, Joshua Mchattan, Varun K A Sreenivasan, T T Hong Duong, Zhenjun Zhao, Marcus A Stoodley
Focussed radiosurgery may provide a means of inducing molecular changes on the luminal surface of diseased endothelium to allow targeted delivery of novel therapeutic compounds. We investigated the potential of ionizing radiation to induce surface expression of intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) on endothelial cells (EC) in vitro and in vivo, to assess their suitability as vascular targets in irradiated arteriovenous malformations (AVMs). Cultured brain microvascular EC were irradiated by linear accelerator at single doses of 0, 5, 15 or 25 Gy and expression of ICAM-1 and VCAM-1 measured by qRT-PCR, Western, ELISA and immunocytochemistry...
2017: PloS One
https://www.readbyqxmd.com/read/28945054/intracranial-stereotactic-radiosurgery
#11
Andrew A Fanous, Dheerendra Prasad, David Mathieu, Andrew J Fabiano
Stereotactic radiosurgery (SRS) is the use of a single high dose of radiation, stereotactically directed to an intracranial region of interest, in order to create a lesion or obliterate a preexisting one. This technology has evolved over the years into the use of multiple radiation sources oriented at a variety of angles, thus permitting the creation of various treatment target shapes. This allows for non-open surgical treatment of intracranial pathologies, which significantly decreases the risk of morbidity...
September 22, 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/28938462/stereotactic-radiosurgery-for-cushing-disease-results-of-an-international-multicenter-study
#12
Gautam U Mehta, Dale Ding, Mohana Rao Patibandla, Hideyuki Kano, Nathaniel Sisterson, Yan-Hua Su, Michal Krsek, Ahmed M Nabeel, Amr El-Shehaby, Khaled A Kareem, Nuria Martinez-Moreno, David Mathieu, Brendan McShane, Kevin Blas, Douglas Kondziolka, Inga Grills, John Y Lee, Roberto Martinez-Alvarez, Wael A Reda, Roman Liscak, Cheng-Chia Lee, L Dade Lunsford, Mary Lee Vance, Jason P Sheehan
Context: Cushing disease (CD) due to adrenocorticotropic hormone-secreting pituitary tumors can be a management challenge. Objective: To better understand the outcomes of stereotactic radiosurgery (SRS) for CD and define its role in management. Design: International, multicenter, retrospective cohort analysis. Setting: Ten medical centers participating in the International Gamma Knife Research Foundation. Patients: Patients with CD with >6 months endocrine follow-up...
November 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28931779/the-efficacy-of-medical-treatment-in-patients-with-acromegaly-in-clinical-practice
#13
Seo Young Lee, Jung Hee Kim, Ji Hyun Lee, Yong Hwy Kim, Hyang Jin Cha, Sang Wan Kim, Sun Ha Paek, Chan Soo Shin
Although somatostatin analogues (SSAs) are recommended as the first-line medical therapy for acromegaly, dopamine agonists (DAs) are also a therapeutic option for treatment. We aimed to assess and compare the efficacies of DAs and SSAs in treating acromegaly in clinical practice. We included 89 patients with acromegaly who took DAs (bromocriptine [BCT], n = 63; cabergoline [CAB], n = 11) or SSAs (n = 15) as a primary medical therapy for more than 3 months in the Seoul National University Hospital. The CAB (45...
September 20, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28917250/emerging-technologies-in-stereotactic-body-radiotherapy
#14
Lijun Ma, Lei Wang, Chia-Lin Tseng, Arjun Sahgal
Stereotactic body radiation therapy (SBRT) stems from the initial developments of intra-cranial stereotactic radiosurgery (SRS). Despite similarity in their names and clinical goals of delivering a sufficiently high tumoricidal dose, maximal sparing of the surrounding normal tissues and a short treatment course, SBRT technologies have transformed from the early days of body frame-based treatments with X-ray verification to primarily image-guided procedures with cone-beam CT or stereoscopic X-ray systems and non-rigid body immo-bilization...
September 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28903963/predictors-of-radio-induced-visual-impairment-after-radiosurgery-for-uveal-melanoma
#15
Carmen Rosaria Gigliotti, Giulio Modorati, Maura Di Nicola, Claudio Fiorino, Lucia Alessia Perna, Elisabetta Miserocchi, Alberto Franzin, Piero Picozzi, Angelo Bolognesi, Pietro Mortini, Antonella Del Vecchio, Riccardo Calandrino
AIMS: The aim of the present work is to assess the main predictors of the most clinically relevant radio-induced effects after Gamma Knife stereotactic radiosurgery (GKRS) for uveal melanoma (UM). MATERIALS AND METHODS: Medical records and three-dimensional dosimetry data of critical structures of 66 patients were retrospectively reviewed. Cox's proportional hazard model was used to identify clinical and dosimetric variables as independent risk factor for GKRS-related complications...
September 13, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28885118/stereotactic-radiosurgery-for-spetzler-martin-grade-iv-and-v-arteriovenous-malformations-an-international-multicenter-study
#16
Mohana Rao Patibandla, Dale Ding, Hideyuki Kano, Zhiyuan Xu, John Y K Lee, David Mathieu, Jamie Whitesell, John T Pierce, Paul P Huang, Douglas Kondziolka, Caleb Feliciano, Rafael Rodriguez-Mercado, Luis Almodovar, Inga S Grills, Danilo Silva, Mahmoud Abbassy, Symeon Missios, Gene H Barnett, L Dade Lunsford, Jason P Sheehan
OBJECTIVE Due to the complexity of Spetzler-Martin (SM) Grade IV-V arteriovenous malformations (AVMs), the management of these lesions remains controversial. The aims of this multicenter, retrospective cohort study were to evaluate the outcomes after single-session stereotactic radiosurgery (SRS) for SM Grade IV-V AVMs and determine predictive factors. METHODS The authors retrospectively pooled data from 233 patients (mean age 33 years) with SM Grade IV (94.4%) or V AVMs (5.6%) treated with single-session SRS at 8 participating centers in the International Gamma Knife Research Foundation...
September 8, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28882603/gamma-knife-surgery-for-a-hemangioma-of-the-cavernous-sinus-in-an-adult-case-report-and-short-review-of-the-literature
#17
L Schwyzer, C Tuleasca, F-X Borruat, I Radovanovic, M Levivier
Cavernous sinus hemangiomas (CSH) are rare benign extra-axial vascular lesions. Both radiological and clinical aspects are important, for deciding a therapeutic modality, including medical treatment, radiation therapy or microsurgery. In the particular case of CSH, a radical removal of the tumor often cannot be achieved and is associated with a considerable risk for intraoperative uncontrollable bleeding. An alternative treatment modality is radiosurgery. Here we report the case of a 45-year-old patient, who presented with diplopia due to left abducens nerve palsy...
September 4, 2017: Neuro-Chirurgie
https://www.readbyqxmd.com/read/28869946/stereotactic-radiosurgery-for-intractable-tremor-dominant-parkinson-disease-a-retrospective-analysis
#18
Sudesh S Raju, Ajay Niranjan, Edward A Monaco Iii, John C Flickinger, L Dade Lunsford
OBJECTIVE: The purpose of this study was to retrospectively analyze the outcomes of stereotactic radiosurgery for patients suffering from medically refractory Parkinson disease (PD) tremor. METHODS: We retrospectively studied the outcomes of 33 patients who were treated with gamma knife thalamotomy (GKT) over a 19-year period. Twelve patients were ≥80 years. A median dose of 140 Gy (range, 130-150 Gy) was delivered to the nucleus ventralis intermedius through a single 4-mm isocenter...
September 2, 2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/28868186/salvage-gamma-knife-radiosurgery-in-the-management-of-dysembryoplastic-neuroepithelial-tumors-long-term-outcome-in-a-single-institution-case-series
#19
Georges Sinclair, Heather Martin, Alia Shamikh, Amir Samadi, Gerald Cooray, Jiri Bartek, Yehya Al-Saffar, Mikael Svensson, Ernest Dodoo
BACKGROUND: Dysembryoplastic neuroepithelial tumors (DNT/DNET) are rare epileptogenic tumors. Microsurgery remains the best treatment option, although case reports exist on the use of gamma knife radiosurgery (GKRS) in selected cases. We investigated the long-term outcome of GKRS-treated DNTs at our institution in the context of current diagnostic and treatment options. CASE DESCRIPTIONS: We conducted a retrospective review of three consecutive adult patients (≥18 years) treated with salvage GKRS between 2002 and 2010 at Karolinska University Hospital, Stockholm, Sweden...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28862549/outcomes-of-stereotactic-radiosurgery-for-foramen-magnum-meningiomas-an-international-multicenter-study
#20
Gautam U Mehta, Georgios Zenonos, Mohana Rao Patibandla, Chung Jung Lin, Amparo Wolf, Inga Grills, David Mathieu, Brendan McShane, John Y Lee, Kevin Blas, Douglas Kondziolka, Cheng-Chia Lee, L Dade Lunsford, Jason P Sheehan
OBJECTIVE Meningiomas are the most common benign extramedullary lesions of the foramen magnum; however, their optimal management remains undefined. Given their location, foramen magnum meningiomas (FMMs) can cause significant morbidity, and complete microsurgical removal can be challenging. Anterior and anterolateral FMMs carry greater risks with surgery, but they comprise the majority of these lesions. As an alternative to resection, stereotactic radiosurgery (SRS) has been used to treat FMMs in small case series...
September 1, 2017: Journal of Neurosurgery
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