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https://www.readbyqxmd.com/read/29773608/what-s-in-a-name-that-which-we-call-ipf-by-any-other-name-would-act-the-same
#1
Athol U Wells, Kevin K Brown, Kevin R Flaherty, Martin Kolb, Victor J Thannickal
Idiopathic pulmonary fibrosis (IPF) remains a truly idiopathic fibrotic disease, with a modest genetic predilection and candidate triggers but no overall explanation for the development of disease in non-familial cases. Agreement on terminology has contributed to major clinical and translational advances since the millennium. It is likely that the entity currently captured by the term "IPF" will be radically reclassified over the next decade, either through "splitting" (into IPF subgroups responding selectively to individual disease-modifying agents) or through "lumping" of IPF with other forms of progressive fibrotic lung disease (with shared pathogenetic mechanisms and IPF-like disease behaviour)...
May 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29771173/communication-and-collaboration-among-return-to-work-stakeholders
#2
Elizabeth Russell, Agnieszka Kosny
PURPOSE: Workers who are injured or become ill on the job are best able to return-to-work when stakeholders involved in their case collaborate and communicate. This study examined health care providers' and case managers' engagement in rehabilitation and return-to-work following workplace injury or illness. METHOD: In-depth interviews were conducted with 97 health care providers and 34 case managers in four Canadian provinces about their experiences facilitating rehabilitation and return-to-work, and interacting with system stakeholders...
May 17, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29762669/ethics-of-oocyte-banking-for-third-party-assisted-reproduction-a-systematic-review
#3
E M Kool, A M E Bos, R van der Graaf, B C J M Fauser, A L Bredenoord
BACKGROUND: The demand for donor oocytes has increased dramatically over the years. Today people in need of ART with the use of donor oocytes can appeal to commercial or public donor oocyte banks. The introduction of oocyte banks has shed a new light on the practice of ART using donor oocytes. The establishment and maintenance of oocyte banks should be sensitive to the ethical considerations. However, it is currently unclear which ethical aspects have to be taken into account. OBJECTIVE AND RATIONALE: The aim of this article is to identify the ethical aspects of establishing and maintaining oocyte banks for third-party ART...
May 14, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/29761318/association-of-sugar-sweetened-beverages-consumption-with-non-alcoholic-fatty-liver-disease-a-systematic-review-and-meta-analysis
#4
REVIEW
Farzaneh Asgari-Taee, Nahid Zerafati-Shoae, Mohsen Dehghani, Masoumeh Sadeghi, Hamid R Baradaran, Shima Jazayeri
PURPOSE: The relationship between consumption of sugar sweetened beverages (SSB) and NAFLD has been reported in several epidemiological studies, but the results are inconsistent. The present systematic review and meta-analysis of observational studies was carried out to assess the relationship between sugar sweetened beverages consumption and NAFLD. METHODS: Online databases were searched systematically through December, 2016 for studies investigating association between SSB consumption and NAFLD but limited to observational studies in human...
May 14, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29759022/compassion-focused-therapy-for-trauma-in-people-with-intellectual-disabilities-a-conceptual-review
#5
Megan Cowles, Cathy Randle-Phillips, Andrew Medley
Trauma exposure and post-traumatic stress disorder are more prevalent in people with intellectual disabilities (PWID) than in the general population, yet the evidence base for trauma interventions in this population is sparse. Compassion-focused therapy (CFT) may be particularly well-suited to PWID for a number of reasons, including its adaptability to different developmental levels. PWID are more likely to have issues with self-relating (e.g. shame and self-criticism) and attachment than the general population, two issues that are compounded by trauma and which CFT explicitly seeks to address...
January 1, 2018: Journal of Intellectual Disabilities: JOID
https://www.readbyqxmd.com/read/29758476/epistemic-tensions-between-people-living-with-asthma-and-healthcare-professionals-in-clinical-encounters
#6
Jennie Haw, Shannon Cunningham, Kieran C O'Doherty
RATIONALE: Asthma is a common respiratory condition with high prevalence rates globally. While there are effective treatments, asthma remains an important health concern as people continue to die from severe attacks. Improving the experiences of, and health outcomes for, people with asthma depends heavily on their interactions with healthcare professionals. Understanding negative clinical encounters will benefit people with asthma and healthcare providers. OBJECTIVE: To examine epistemic tensions in negative clinical encounters from a patient perspective, with an aim to better understand how patients respond to these tensions...
May 1, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29756447/electrochemical-methodologies-for-the-detection-of-pathogens
#7
Mandana Amiri, Abolfazl Bezaatpour, Hamed Jafari, Rabah Boukherroub, Sabine Szunerits
Bacterial infections remain of the principal causes of morbidity and mortality worldwide. The number of death due to infections is declining every year by only 1% with a forecast of 13 million deaths in 2050. Among the 1400 recognized human pathogens, the majority of infectious diseases is caused by just a few, about 20 pathogens only. While the development of vaccinations and novel anti-bacterial drugs and treatments are at the forefront of research, and strongly financially supported by policy makers, another manner to limit and control infectious outbreaks is targeting the development and implementation of early warning systems, which indicate qualitatively and quantitatively the presence of a pathogen...
May 14, 2018: ACS Sensors
https://www.readbyqxmd.com/read/29754239/bio-algorithmic-workflows-for-standardized-synthetic-biology-constructs
#8
Angel Goñi-Moreno, Víctor de Lorenzo
A synthetic biology workflow covers the roadmap from conceptualization of a genetic device to its construction and measurement. It is composed of databases that provide DNA parts/plasmids, wet-lab methods , software tools to design circuits, simulation packages , and tools to analyze circuit performance. The interdisciplinary nature of such a workflow requires that experimental results and their in-silico counterparts proceed alongside, with constant feedback between them. We present an end-to-end use case for engineering a simple synthetic device, where information standards maintain coherence throughout the workflow...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29748850/from-aggression-to-autism-new-perspectives-on-the-behavioral-sequelae-of-monoamine-oxidase-deficiency
#9
REVIEW
Marco Bortolato, Gabriele Floris, Jean C Shih
The two monoamine oxidase (MAO) enzymes, A and B, catalyze the metabolism of monoamine neurotransmitters, such as serotonin, norepinephrine, and dopamine. The phenotypic outcomes of MAO congenital deficiency have been studied in humans and animal models, to explore the role of these enzymes in behavioral regulation. The clinical condition caused by MAOA deficiency, Brunner syndrome, was first described as a disorder characterized by overt antisocial and aggressive conduct. Building on this discovery, subsequent studies were focused on the characterization of the role of MAOA in the neurobiology of antisocial conduct...
May 10, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29743068/facilitating-the-implementation-of-clinical-technology-in-healthcare-what-role-does-a-national-agency-play
#10
Gill Harvey, Sue Llewellyn, Greg Maniatopoulos, Alan Boyd, Rob Procter
BACKGROUND: Accelerating the implementation of new technology in healthcare is typically complex and multi-faceted. One strategy is to charge a national agency with the responsibility for facilitating implementation. This study examines the role of such an agency in the English National Health Service. In particular, it compares two different facilitation strategies employed by the agency to support the implementation of insulin pump therapy. METHODS: The research involved an empirical case study of four healthcare organisations receiving different levels of facilitation from the national agency: two received active hands-on facilitation; one was the intended recipient of a more passive, web-based facilitation strategy; the other implemented the technology without any external facilitation...
May 10, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29740372/large-scale-brain-simulation-and-disorders-of-consciousness-mapping-technical-and-conceptual-issues
#11
Michele Farisco, Jeanette H Kotaleski, Kathinka Evers
Modeling and simulations have gained a leading position in contemporary attempts to describe, explain, and quantitatively predict the human brain's operations. Computer models are highly sophisticated tools developed to achieve an integrated knowledge of the brain with the aim of overcoming the actual fragmentation resulting from different neuroscientific approaches. In this paper we investigate the plausibility of simulation technologies for emulation of consciousness and the potential clinical impact of large-scale brain simulation on the assessment and care of disorders of consciousness (DOCs), e...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29734596/untangling-the-effects-of-shallow-groundwater-and-deficit-irrigation-on-irrigation-water-productivity-in-arid-region-new-conceptual-model
#12
Jingyuan Xue, Zailin Huo, Fengxin Wang, Shaozhong Kang, Guanhua Huang
Water scarcity and salt stress are two main limitations for agricultural production. Groundwater evapotranspiration (ETg ) with upward salt movement plays an important role in crop water use and water productivity in arid regions, and it can compensate the impact of deficit irrigation on crop production. Thus, comprehensive impacts of shallow groundwater and deficit irrigation on crop water use results in an improvement of irrigation water productivity (IWP). However, it is difficult to quantify the effects of groundwater and deficit irrigation on IWP...
April 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29731375/healthcare-professionals-perceptions-related-to-the-provision-of-clinical-pharmacy-services-in-the-public-health-sector-of-mexico-a-case-study
#13
Christian Díaz de León-Castañeda, Jéssica Gutiérrez-Godínez, Juventino Iii Colado-Velázquez, Cairo Toledano-Jaimes
BACKGROUND: In Mexico, the Modelo Nacional de Farmacia Hospitalaria (MNFH, or National Hospital Pharmacy Model), published in 2009, mainly aims to promote the provision of clinical pharmacy services in private and public hospitals. However, there is little scientific documentation about the quality of these services. OBJECTIVES: To explore healthcare professionals' perceptions related to the quality of clinical pharmacy services provision. METHODS: A case-study based on a qualitative approach was performed at the pharmaceutical services unit at a public hospital located in Mexico City, which operates under the administrative control of the Ministry of Health...
April 22, 2018: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/29730617/what-is-the-epidemiology-of-medication-errors-error-related-adverse-events-and-risk-factors-for-errors-in-adults-managed-in-community-care-contexts-a-systematic-review-of-the-international-literature
#14
Ghadah Asaad Assiri, Nada Atef Shebl, Mansour Adam Mahmoud, Nouf Aloudah, Elizabeth Grant, Hisham Aljadhey, Aziz Sheikh
OBJECTIVE: To investigate the epidemiology of medication errors and error-related adverse events in adults in primary care, ambulatory care and patients' homes. DESIGN: Systematic review. DATA SOURCE: Six international databases were searched for publications between 1 January 2006 and 31 December 2015. DATA EXTRACTION AND ANALYSIS: Two researchers independently extracted data from eligible studies and assessed the quality of these using established instruments...
May 5, 2018: BMJ Open
https://www.readbyqxmd.com/read/29723806/bioelectrical-coupling-in-multicellular-domains-regulated-by-gap-junctions-a-conceptual-approach
#15
REVIEW
Javier Cervera, Alexis Pietak, Michael Levin, Salvador Mafe
We review the basic concepts involved in bioelectrically-coupled multicellular domains, focusing on the role of membrane potentials (Vmem ). In the first model, single-cell Vmem is modulated by two generic polarizing and depolarizing ion channels, while intercellular coupling is implemented via voltage-gated gap junctions. Biochemical and bioelectrical signals are integrated via a feedback loop between Vmem and the transcription and translation of a protein forming an ion channel. The effective rate constants depend on the single-cell Vmem because these potentials modulate the local concentrations of signaling molecules and ions...
April 21, 2018: Bioelectrochemistry
https://www.readbyqxmd.com/read/29722388/aromaticity-of-acenes-the-model-of-migrating-%C3%AF-circuits
#16
Dariusz W Szczepanik, Miquel Solà, Tadeusz M Krygowski, Halina Szatylowicz, Marcin Andrzejak, Barbara Pawełek, Justyna Dominikowska, Mercedes Kukułka, Karol Dyduch
In this work we extend the concept of migrating Clar's sextets to explain local aromaticity trends in linear acenes predicted by theoretical calculations and experimental data. To assess the link between resonance and reactivity and to rationalize the constant-height AFM image of pentacene we used the electron density of delocalized bonds and other functions of the one-electron density from conceptual density functional theory. The presented results provide evidence for migration of Clar's π-sextets and larger circuits in these systems, and clearly show that the link between the theoretical concept of aromaticity and the real electronic structure entails the separation of intra- and inter-ring resonance effects, which in the case of [n]acenes (n = 3, 4, 5) comes down to solving a system of simple linear equations...
May 3, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29720366/studying-cannabis-use-behaviors-with-facebook-and-web-surveys-methods-and-insights
#17
Jacob T Borodovsky, Lisa A Marsch, Alan J Budney
The rapid and wide-reaching expansion of internet access and digital technologies offers epidemiologists numerous opportunities to study health behaviors. One particularly promising new data collection strategy is the use of Facebook's advertising platform in conjunction with Web-based surveys. Our research team at the Center for Technology and Behavioral Health has used this quick and cost-efficient method to recruit large samples and address unique scientific questions related to cannabis use. In conducting this research, we have gleaned several insights for using this sampling method effectively and have begun to document the characteristics of the resulting data...
May 2, 2018: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/29716464/-attachment-based-short-intervention-during-inpatient-treatment-of-adolescents
#18
Ann-Christin Jahnke-Majorkovits, Anna Buchheim
Attachment Based Short Intervention During Inpatient Treatment of Adolescents In clinical attachment research the established and economic Adult Attachment Projective Picture System (AAP) has been increasingly used in the past few years to assess the attachment representations in adults and recent studies demonstrated sufficient validity for assessing attachment representations in adolescents. Apart from coding attachment classifications, the AAP provides useful and clinically valid information concerning attachment related defences, aspects of capacity to act and synchrony in relationships and emotion regulation strategies with respect to attachment related traumatic experiences...
May 2018: Praxis der Kinderpsychologie und Kinderpsychiatrie
https://www.readbyqxmd.com/read/29716397/assessing-protective-factors-for-adolescent-offending-a-conceptually-informed-examination-of-the-savry-and-yls-cmi
#19
Jodi L Viljoen, Aisha K Bhanwer, Catherine S Shaffer, Kevin S Douglas
Although the Structured Assessment of Violence Risk in Youth (SAVRY) and the Youth Level of Service/Case Management Inventory (YLS/CMI) are among the most widely used adolescent risk assessment tools, they conceptualize and measure strengths differently. As such, in this study, we compared the predictive validity of SAVRY Protective Total and YLS/CMI Strength Total, and tested conceptual models of how these measures operate (i.e., risk vs. protective effects, direct vs. buffering effects, causal models). Research assistants conducted 624 risk assessments with 156 youth on probation...
April 1, 2018: Assessment
https://www.readbyqxmd.com/read/29714174/sls-2-the-upgrade-of-the-swiss-light-source
#20
Andreas Streun, Terence Garvey, Lenny Rivkin, Volker Schlott, Thomas Schmidt, Philip Willmott, Albin Wrulich
An upgrade of the Swiss Light Source (SLS) is planned for 2021-2024 and includes the exchange of the existing storage ring by a new one providing about 40-50 times lower emittance in user operation mode. This will extend the performance of SLS in particular in the fields of coherent imaging, full-field tomography, soft X-ray angle-resolved photoelectron spectroscopy and resonant inelastic X-ray scattering. A science case and a conceptual design for the machine have been established. As a summary of these reports, the novel lattice design, undulator developments and scientific highlights are presented...
May 1, 2018: Journal of Synchrotron Radiation
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