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https://www.readbyqxmd.com/read/28527568/evolution-of-nuclear-receptors-and-ligand-signaling-toward-a-soft-key-lock-model
#1
Guillaume Holzer, Gabriel V Markov, Vincent Laudet
Nuclear receptors (NRs) are a family of ligand-regulated transcription factors that modulate a wide variety of physiological functions in a ligand-dependent manner. The first NRs were discovered as receptors of well-known hormones such as 17β-estradiol, corticosteroids, or thyroid hormones. In these cases a direct activation of the receptor transcriptional activity by a very specific ligand, with nanomolar affinity, was demonstrated, providing a strong conceptual framework to understand the mechanism of action of these hormones...
2017: Current Topics in Developmental Biology
https://www.readbyqxmd.com/read/28527018/predicting-academic-impairment-and-internalizing-psychopathology-using-a-multidimensional-framework-of-sluggish-cognitive-tempo-with-parent-and-adolescent-reports
#2
Zoe R Smith, Joshua M Langberg
Adolescents with Sluggish Cognitive Tempo (SCT) exhibit symptoms of slowness, mental confusion, excessive daydreaming, low motivation, and drowsiness/sleepiness. Although many symptoms of SCT reflect internalizing states, no study has evaluated the clinical utility of self-report of SCT in an attention-deficit/hyperactivity disorder (ADHD) sample. Furthermore, it remains unclear whether SCT is best conceptualized as a unidimensional or multidimensional construct. In a sample of 262 adolescents comprehensively diagnosed with ADHD, the present study used adolescent- and parent reports of SCT to evaluate the predictive utility of a general SCT factor from a bifactor modeling approach compared the utility of three specific SCT factors (slow, sleepy, and daydreamer) for predicting academic impairment and internalizing psychopathology...
May 19, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28520974/the-neuropsychological-assessment-of-justice-involved-men-descriptive-analysis-preliminary-data-and-a-case-for-group-specific-norms
#3
Casey LaDuke, David DeMatteo, Kirk Heilbrun, Jennifer Gallo, Thomas Swirsky-Sacchetti
Objective: Neuropsychological expertise has played an increasing role in legal decision-making in criminal contexts. Valid neuropsychological evidence in criminal forensic contexts requires normative data that are representative of justice-involved individuals. Unfortunately, existing normative data appear unlikely to represent justice-involved individuals due to significant demographic and clinical factors specific to this population. As a result, the interpretation of neuropsychological performance with justice-involved individuals using existing normative data may increase the risk of inaccurate description, invalid clinical conceptualization, misdiagnosis of impairment, and misattribution of deficits in functional-legal capacities...
May 18, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28520407/controlling-configurational-isomerism-in-three-component-colloidal-hybrid-nanoparticles
#4
James M Hodges, Raymond E Schaak
Colloidal hybrid nanoparticles are solution-dispersible constructs that join together multiple distinct nanoscale materials through direct solid-solid interfaces. Given their multifunctionality and synergistic properties that emerge from interfacial coupling, hybrid nanoparticles are of interest for applications in biomedical imaging, solar energy conversion, heterogeneous catalysis, nanophotonics, and beyond. High-order hybrid nanoparticles, which incorporate three or more nanocrystal domains, offer greater tunability and functional diversity relative to one or two-component nanoparticles...
May 18, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28515983/a-conceptual-model-for-physical-therapists-treating-athletes-with-protracted-recovery-following-a-concussion
#5
Mark Lundblad
Sports-related concussions are receiving growing attention in healthcare. Most concussions resolve spontaneously with little or no treatment, but twenty percent of concussions take longer than three weeks to resolve. In some cases, symptoms can last for five years following a traumatic brain injury. Physical Therapists have unique skills that can assist patients experiencing protracted recovery. The purpose of this clinical commentary is to describe a new conceptual model that provides a framework for Physical Therapy management of patients with protracted recovery following a sports-related concussion...
April 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/28514910/value-based-healthcare-measurement-as-a-context-for-organizational-learning
#6
Patrik Nordin, Anna-Aurora Kork, Inka Koskela
Purpose The purpose of this paper is to shed light on the potential of organizational learning for developing effectiveness of care. Value-based healthcare measurement recognizes patient value as a driver for improving health outcomes at the societal and individual levels. By using the action learning method, this paper examines the phases of organizational learning in a private healthcare organization that has developed a novel Big Data screening tool for the treatment of patients with type 2 diabetes mellitus (DM2)...
May 2, 2017: Leadership in Health Services
https://www.readbyqxmd.com/read/28514475/cotreatment-as-a-vehicle-for-interprofessional-collaborative-practice-physical-therapists-and-speech-language-pathologists-collaborating-in-the-care-of-children-with-severe-disabilities
#7
Lorraine Sylvester, Billy T Ogletree, Karen Lunnen
Purpose: This article defines interprofessional collaborative practice and links its key features with accepted practice conceptualizations of physical therapy. Cotreatment with speech-language pathology is described as a vehicle for interprofessional collaborative practice for children with severe disabilities. Method: The article reviews the International Classification of Functioning, Disability, and Health (WHO, 2015) and the Hypothesis-Oriented Algorithm for Clinicians II (Rothstein, Echternach, & Riddle, 2003) as existing service-delivery frameworks in physical therapy and discusses how interprofessional collaborative practice between speech-language pathologists and physical therapists can be useful within these practice guidelines...
May 17, 2017: American Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/28511729/juicy-conceptualizations-increasing-alliance-through-attending-to-client-metaphoric-language
#8
Fiona Mathieson, Jennifer Jordan, Paul Merrick, Maria Stubbe
BACKGROUND: There is increasing interest in the use of metaphor in cognitive behaviour therapy. Experts advocate bringing client metaphors into case conceptualizations, but there is little empirical research to support this. AIMS: This study evaluated the effect of training 12 therapists to attend to client metaphors and bring them into case conceptualizations. METHOD: Pre- and post-training role-played therapy sessions were conducted and video-recorded...
May 17, 2017: Behavioural and Cognitive Psychotherapy
https://www.readbyqxmd.com/read/28511720/identifying-models-of-delivery-care-domains-and-quality-indicators-relevant-to-palliative-day-services-a-scoping-review-protocol
#9
Seán R O'Connor, Martin Dempster, Noleen K McCorry
BACKGROUND: With an ageing population and increasing numbers of people with life-limiting illness, there is a growing demand for palliative day services. There is a need to measure and demonstrate the quality of these services, but there is currently little agreement on which aspects of care should be used to do this. The aim of the scoping review will be to map the extent, range and nature of the evidence around models of delivery, care domains and existing quality indicators used to evaluate palliative day services...
May 16, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28511571/brain-injury-and-offending-the-development-and-field-testing-of-a-linkworker-intervention
#10
Sara D S Ramos, Michael Oddy, James Liddement, Deborah Fortescue
Evidence suggests that traumatic brain injury (TBI) is more prevalent amongst offender populations than in the general population, and that it can lead to aggressive behaviour while in custody and impair engagement with offender rehabilitation programmes. The aim of this study was to develop, implement, and evaluate a brain injury Linkworker approach designed to support prisoners who report a significant TBI or multiple mild TBIs. Three clinical case examples are reported to illustrate the conceptual foundations of the approach and to demonstrate the feasibility of the service...
May 1, 2017: International Journal of Offender Therapy and Comparative Criminology
https://www.readbyqxmd.com/read/28508789/propose-of-standards-based-it-architecture-to-enrich-the-value-of-allergy-data-by-telemonitoring-data
#11
Philipp Urbauer, Maximilian Kmenta, Matthias Frohner, Alexander Mense, Stefan Sauermann
Interoperability is a key requirement for any IT-System to be future proof and cost efficient, due to the increasing interaction of IT-Systems in Healthcare. This feasibility study is part of a larger project focusing on the conceptualization and evaluation of interoperable and modular IT-Framework components for exchanging big data information sets. Hence, this project investigates the applicability of a standard based IT-Architecture for the integration of Personal Health Devices data and open data sources...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28508127/transcending-landscapes-working-across-scales-and-levels-in-pastoralist-rangeland-governance
#12
Lance W Robinson, Enoch Ontiri, Tsegaye Alemu, Stephen S Moiko
Landscape approaches can be subjected to mistakenly targeting a single "best" level of governance, and paying too little attention to the role that cross-scale and cross-level interactions play in governance. In rangeland settings, resources, patterns of use of those resources, and the institutions for managing the resources exist at multiple levels and scales. While the scholarship on commons offers some guidance on how to conceptualize governance in rangeland landscapes, some elements of commons scholarship-notably the "design principles" for effective governance of commons-do not seem to apply neatly to governance in pastoralist rangeland settings...
May 15, 2017: Environmental Management
https://www.readbyqxmd.com/read/28506296/worlds-apart-a-scoping-review-addressing-different-stakeholder-perspectives-on-barriers-to-family-involvement-in-the-care-for-persons-with-severe-mental-illness
#13
Elleke Landeweer, Bert Molewijk, Marit Helene Hem, Reidar Pedersen
BACKGROUND: Empirical evidence shows that family involvement (FI) can play a pivotal role in the coping and recovery of persons with severe mental illness (SMI). Nevertheless, various studies demonstrate that FI in mental healthcare services is often not (sufficiently) realized. In order to develop more insights, this scoping review gives an overview of how various stakeholders conceptualize, perceive and experience barriers to FI. Central questions are: 1) What are the main barriers to FI reported by the different key stakeholders (i...
May 15, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28504522/the-construct-behavior-gap-in-behavioral-decision-research-a-challenge-beyond-replicability
#14
Michel Regenwetter, Maria M Robinson
Behavioral decision research compares theoretical constructs like preferences to behavior such as observed choices. Three fairly common links from constructs to behavior are (1) to tally, across participants and decision problems, the number of choices consistent with one predicted pattern of pairwise preferences; (2) to compare what most people choose in each decision problem against a predicted preference pattern; or (3) to enumerate the decision problems in which two experimental conditions generate a 1-sided significant difference in choice frequency 'consistent' with the theory...
May 15, 2017: Psychological Review
https://www.readbyqxmd.com/read/28503332/chronic-neuropsychological-sequelae-in-a-patient-with-nontumorous-anti-nmda-receptor-encephalitis
#15
Dong Y Han, Lisa M Koehl, Aarti Patel, Zhengqiu Zhou, Sarah Phillips, Siddharth Kapoor
Anti-N-methyl-D-aspartate receptor encephalitis is a neurological, autoimmune disorder tightly conceptualized only as recently as the mid-2000s. It presents itself in a combination of psychiatric, neurological, and autonomic features. We observe a unique case with probable earlier episode (prior to the mid-2000s conceptualization of the disease) and a later relapse, accompanying a comprehensive neuropsychological profile tracked after the relapse and subsequent improvement. Neurocognitive findings revealed residual frontal deficits with mood changes even in the state after plasmapheresis...
2017: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/28500981/some-consequences-of-normal-aging-for-generating-conceptual-explanations-a-case-study-of-vitalist-biology
#16
Nathan Tardiff, Igor Bascandziev, Kaitlin Sandor, Susan Carey, Deborah Zaitchik
Accumulating evidence suggests that not only diseases of old age, but also normal aging, affect elderly adults' ability to draw on the framework theories that structure our abstract causal-explanatory knowledge, knowledge that we use to make sense of the world. One such framework theory, the cross-culturally universal vitalist biology, gives meaning to the abstract concepts life and death. Previous work shows that many elderly adults are animists, claiming that active, moving entities such as the sun and the wind are alive (Zaitchik & Solomon, 2008)...
June 2017: Cognitive Psychology
https://www.readbyqxmd.com/read/28499575/childhood-enuresis-current-diagnostic-formulations-salient-findings-and-effective-treatment-modalities
#17
REVIEW
Steven Thurber
Enuresis constitutes a frequently encountered problem area for children that may adversely affect social and emotional adjustment. This type of incontinence has been of concern to the human family for centuries. A brief history of enuresis is presented followed by current conceptualizations, diagnostic criteria, prevalence rates and psychiatric comorbidities. Historic notions of causation together with ineffective, sometimes barbaric treatments are then discussed, ending with a presentation of evidence-based treatment modalities, with the urine alarm being an essential element of effective treatment...
June 2017: Archives of Psychiatric Nursing
https://www.readbyqxmd.com/read/28498581/the-contemporary-refugee-crisis-an-overview-of-mental-health-challenges
#18
Derrick Silove, Peter Ventevogel, Susan Rees
There has been an unprecedented upsurge in the number of refugees worldwide, the majority being located in low-income countries with limited resources in mental health care. This paper considers contemporary issues in the refugee mental health field, including developments in research, conceptual models, social and psychological interventions, and policy. Prevalence data yielded by cross-sectional epidemiological studies do not allow a clear distinction to be made between situational forms of distress and frank mental disorder, a shortcoming that may be addressed by longitudinal studies...
June 2017: World Psychiatry: Official Journal of the World Psychiatric Association (WPA)
https://www.readbyqxmd.com/read/28495495/translating-in-vitro-ligand-bias-into-in-vivo-efficacy
#19
REVIEW
Louis M Luttrell, Stuart Maudsley, Diane Gesty-Palmer
It is increasingly apparent that ligand structure influences both the efficiency with which G protein-coupled receptors (GPCRs) engage their downstream effectors and the manner in which they are activated. Thus, 'biased' agonists, synthetic ligands whose intrinsic efficacy differs from the native ligand, afford a strategy for manipulating GPCR signaling in ways that promote beneficial signals while blocking potentially deleterious ones. Still, there are significant challenges in relating in vitro ligand efficacy, which is typically measured in heterologous expression systems, to the biological response in vivo, where the ligand is acting on natively expressed receptors and in the presence of the endogenous ligand...
May 7, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28495121/approaches-to-appropriate-care-delivery-from-a-policy-perspective-a-case-study-of-australia-england-and-switzerland
#20
Joelle Robertson-Preidler, Matthew Anstey, Nikola Biller-Andorno, Alexandra Norrish
BACKGROUND: Appropriateness is a conceptual way for health systems to balance Triple Aim priorities for improving population health, containing per capita cost, and improving the patient experience of care. Comparing system approaches to appropriate care delivery can help health systems establish priorities and facilitate appropriate care practices. METHODS: We conceptualized system appropriateness by identifying policies that aim to achieve the Triple Aim and their consequent trade-offs for financing, clinical practice, and the individual patient...
April 29, 2017: Health Policy
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