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https://www.readbyqxmd.com/read/27516176/gastroschisis-in-uganda-opportunities-for-improved-survival
#1
Anne S Wesonga, Tamara N Fitzgerald, Ronald Kabuye, Samuel Kirunda, Monica Langer, Nasser Kakembo, Doruk Ozgediz, John Sekabira
PURPOSE: Neonatal mortality from gastroschisis in sub-Saharan Africa is high, while in high-income countries, mortality is less than 5%. The purpose of this study was to describe the maternal and neonatal characteristics of gastroschisis in Uganda, estimate the mortality and elucidate opportunities for intervention. METHODS: An ethics-approved, prospective cohort study was conducted over a one-year period. All babies presenting with gastroschisis in Mulago Hospital in Kampala, Uganda were enrolled and followed up to 30days...
November 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/26879849/timing-of-malaria-in-pregnancy-and-impact-on-infant-growth-and-morbidity-a-cohort-study-in-uganda
#2
Pierre De Beaudrap, Eleanor Turyakira, Carolyn Nabasumba, Benon Tumwebaze, Patrice Piola, Yap Boum Ii, Rose McGready
BACKGROUND: Malaria in pregnancy (MiP) is a major cause of fetal growth restriction and low birth weight in endemic areas of sub-Saharan Africa. Understanding of the impact of MiP on infant growth and infant risk of malaria or morbidity is poorly characterized. The objective of this study was to describe the impact of MIP on subsequent infant growth, malaria and morbidity. METHODS: Between 2006 and 2009, 82 % (832/1018) of pregnant women with live-born singletons and ultrasound determined gestational age were enrolled in a prospective cohort with active weekly screening and treatment for malaria...
February 16, 2016: Malaria Journal
https://www.readbyqxmd.com/read/26409812/lessons-learnt-from-enrolment-and-follow-up-of-pregnant-women-and-their-infants-in-clinical-trials-in-south-africa-a-low-middle-income-country
#3
RANDOMIZED CONTROLLED TRIAL
Clare L Cutland, Marianne Cunnington, Morounfolu Olugbosi, Stephanie A Jones, Andrea Hugo, Karishma Maharaj, Karen Slobod, Shabir A Madhi
INTRODUCTION: Infectious causes are a significant contributor to morbidity and mortality in neonates and young infants. Immunization of pregnant women to protect the mother and/or her infant is gaining momentum due to the benefits of this strategy demonstrated in numerous implemented strategies (Maternal and Neonatal Tetanus Elimination Initiative) and clinical trials. Reluctance by regulators, participants and healthcare providers to include pregnant women in clinical trials is considerable, but reducing...
November 25, 2015: Vaccine
https://www.readbyqxmd.com/read/26389632/ultrasound-in-africa-what-can-really-be-done
#4
Labaran Dayyabu Aliyu, Asim Kurjak, Tuangsit Wataganara, Renato Augusto Moreira de Sá, Ritsuko Pooh, Cihat Sen, Alaa Ebrashy, Abdallah Adra, Milan Stanojevic
Today we are living in a globalized world in which information on what is happening in one part of the world is easily communicated to other parts of the world. This happens thanks to advancement in science and technology. One area where technology has made the greatest impact is heath care provision. Ultrasound technology is now playing a critical role in health care provision particularly in Obstetrics and Gynaecology. This has significantly assisted in provision of quality health care to pregnant women and their unborn infants and in reducing maternal and neonatal morbidity and mortality in the developed world...
March 2016: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/26229508/maternal-ophthalmic-artery-doppler-velocimetry-in-pre-eclampsia-in-southwestern-nigeria
#5
Richard Busayo Olatunji, Ademola Joseph Adekanmi, Millicent Olubunmi Obajimi, Olumuyiwa Adebola Roberts, Temitope Olumuyiwa Ojo
BACKGROUND: Pre-eclampsia (PE) poses a serious challenge to maternal and fetal health in Africa. It is associated with hemodynamic changes that may affect the internal carotid/ophthalmic artery circulation with consequent neuro-ophthalmic manifestations. Ophthalmic artery Doppler (OAD) ultrasound is an important tool that can be used to detect hemodynamic changes in PE and monitor its severity. In this study, we evaluated hemodynamic changes on OAD ultrasound in the ophthalmic arteries of pre-eclamptic women and compared these with values in healthy pregnant women...
2015: International Journal of Women's Health
https://www.readbyqxmd.com/read/25085521/factors-associated-with-thymic-size-at-birth-among-low-and-normal-birth-weight-infants
#6
Helle Brander Eriksen, Sofie Biering-Sørensen, Najaaraq Lund, Cizete Correia, Amabelia Rodrigues, Andreas Andersen, Henrik Ravn, Peter Aaby, Dorthe L Jeppesen, Christine Stabell Benn
OBJECTIVE: To study the effect of gestational and perinatal exposures on thymic size in 366 normal birth weight and 426 low birth weight (LBW) neonates in Guinea-Bissau in West Africa. STUDY DESIGN: In a cross-sectional study, thymic size was measured at birth by the use of ultrasound. Information on possible determinants was collected from pregnancy cards, hospital records, and interviews with the mother. We used the log-transformed thymic index and thymus/weight index as outcome measures...
October 2014: Journal of Pediatrics
https://www.readbyqxmd.com/read/24595186/factors-associated-with-preterm-early-preterm-and-late-preterm-birth-in-malawi
#7
Nynke R van den Broek, Rachel Jean-Baptiste, James P Neilson
BACKGROUND: Assessment of risk factors for preterm birth in a population with high incidence of preterm birth and HIV infection. METHODS: Secondary analysis of data for 2,149 women included in a community based randomized placebo controlled trial for the prevention of preterm birth (APPLe trial (ISRCTN84023116) with gestational age at birth determined through ultrasound measurement in early pregnancy. Multivariate Logistic Regression analyses to obtain models for three outcome variables: all preterm, early preterm, and late preterm birth...
2014: PloS One
https://www.readbyqxmd.com/read/23919183/an-appraisal-of-the-management-of-ectopic-pregnancy-in-a-nigerian-tertiary-hospital
#8
Ao Igwegbe, Gu Eleje, Bc Okpala
BACKGROUND: Ectopic pregnancy has remained a significant cause of maternal morbidity and mortality especially in the sub Saharan Africa. A periodic appraisal of its management is paramount. AIM: To determine the incidence and associated risk factors, for ectopic pregnancy, review available treatment modalities and suggest interventions to reduce its prevalence, morbidity and mortality. MATERIALS AND METHODS: A cross sectional study with retrolective data collection of all cases of ectopic pregnancy managed in Nnamdi Azikiwe University Teaching Hospital, Nnewi, south-east Nigeria between 1(st) January, 2002 and 31(st) December, 2011 was undertaken...
April 2013: Annals of Medical and Health Sciences Research
https://www.readbyqxmd.com/read/23444768/ruptured-subcapsular-liver-hematoma-and-pregnancy-a-rare-complication-of-severe-preeclampsia-a-report-of-a-case-discovered-fortuitously-at-the-maternity-teaching-hospital-of-cocody
#9
K L P Nguessan, D B Mian, D Gondo, A Koffi, C Alla
We report a case of spontaneous rupture of a subcapsular hematoma of the liver (SHL). It was discovered incidentally at the end of an emergency exploratory laparotomy performed due to unexplained hemoperitoneum with hypovolemic shock which occurred with severe preeclampsia. Diagnosis and therapeutic management are very difficult in sub-Saharan Africa due in part to the limitations and lack of medical equipment. The prognosis is usually marked by the death of the patient, as in our case. Through this clinical observation we wanted to show the interest in performing a liver ultrasound at any level of preeclampsia to detect liver abnormalities as soon as possible...
2012: Clinical and Experimental Obstetrics & Gynecology
https://www.readbyqxmd.com/read/23237125/late-termination-of-pregnancy-by-intracardiac-potassium-chloride-injection-5-years-experience-at-a-tertiary-referral-centre
#10
COMPARATIVE STUDY
L Govender, J Moodley
OBJECTIVES: To report our experience with intracardiac potassium chloride (KCl) injection as a method of feticide for severe congenital abnormalities beyond 24 weeks' gestation. METHOD: A retrospective chart review. Patient demographics and types of fetal anomalies were analysed according to the groups that accepted or declined late termination of pregnancy (LTOP, ≥24 weeks) for severe congenital abnormalities. RESULTS: Of 3 896 women referred to the Fetal Medicine Unit at Inkosi Albert Luthuli Central Hospital, KwaZulu-Natal, 2 209 (56...
October 25, 2012: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/23175875/spinal-neural-tube-defects-in-lagos-university-teaching-hospital-nigeria
#11
O B Bankole, S O Arigbabu, O O Kanu
BACKGROUND: The incidence of neural tube defects is known to vary among regions. Very little has been reported about the incidence in Sub-Saharan Africa except for the general impression that the prevalent rates are low. OBJECTIVE: To determine the profile of patients presenting with neural tube defects in Lagos, Nigeria METHODS: We studied all patients with congenital midline back swellings presenting to one of two neurosurgical services in the state over a 5-year period to establish the incidence of spina bifida and develop demographic data...
January 2012: Nigerian Quarterly Journal of Hospital Medicine
https://www.readbyqxmd.com/read/21626982/effectiveness-of-prenatal-screening-for-down-syndrome-on-the-basis-of-maternal-age-in-cape-town
#12
M F Urban, C Stewart, T Ruppelt, L Geerts
OBJECTIVE: The prenatal screening programme for Down syndrome (DS) in the South African public health sector remains primarily based on advanced maternal age (AMA). We assessed the changes over time and effectiveness of this screening programme within a Cape Town health district. METHODS: Retrospective analysis of the Groote Schuur Hospital Cytogenetic Laboratory and Pregnancy Counselling Clinic databases and audit of maternal delivery records at a primary health care facility...
January 2011: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/21621717/a-global-reference-for-fetal-weight-and-birthweight-percentiles
#13
Rafael T Mikolajczyk, Jun Zhang, Ana Pilar Betran, João Paulo Souza, Rintaro Mori, A Metin Gülmezoglu, Mario Merialdi
BACKGROUND: Definition of small for gestational age in various populations worldwide remains a challenge. References based on birthweight are deficient for preterm births, those derived from ultrasound estimates might not be applicable to all populations, and the individualised reference can be too complex to use in developing countries. Our aim was to create a generic reference for fetal weight and birthweight that overcame these deficiencies and could be readily adapted to local populations...
May 28, 2011: Lancet
https://www.readbyqxmd.com/read/21516988/sickle-cell-disease-from-africa-to-belgium-from-neonatal-screening-to-clinical-management
#14
Phu Quoc Lê, A Ferster, F Cotton, F Vertongen, C Vermylen, A Vanderfaeillie, L Dedeken, C Heijmans, O Ketelslegers, M F Dresse, B Gulbis
AIM: To describe the severity of sickle cell disease (SCD) in newborns in Belgium and evaluate the impact of neonatal screening (NS) on clinical outcome. METHODS: Universal NS of umbilical cord blood for hemoglobinopathy was progressively deployed in Brussels and Liège starting in 1994. No particular population was targeted. Samples were analyzed initially using the isoelectric focusing technique and since 2008 the capillary electrophoresis technique. If a hemoglobin variant was suspected, further analysis was carried out using high performance liquid chromatography...
December 2010: Médecine Tropicale: Revue du Corps de Santé Colonial
https://www.readbyqxmd.com/read/20488861/cranial-ultrasound-findings-in-well-newborn-ugandan-infants
#15
C F Hagmann, N J Robertson, D Acolet, D Chan, S Onda, N Nyombi, M Nakakeeto, F M Cowan
BACKGROUND: There has been no study assessing cranial ultrasound (cUS) scans in newborn infants born in equatorial Africa. OBJECTIVE: To assess the cUS scans of apparently well newborn term Ugandan infants and to correlate the findings with perinatal data. METHODS: An observational study of apparently healthy postnatal ward term Ugandan infants at Mulago Hospital, Makerere University Hospital, Kampala, Uganda. RESULTS: Data from 112 infants scanned at a median age of 1...
September 2010: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/19666372/-placenta-praevia-maternal-and-featal-prognosis-in-university-hospital-of-cocody-abidjan-cote-d-ivoire
#16
K N'guessan, F Kouakou, V Loué, V Angoi, Y Abauleth, S Boni
INTRODUCTION: In Africa, in spite of systematical practice of echography, Placenta praevia (PP) remains a high risky gravid complication, very unpredictable, with a high lethality rate. OBJECTIVES: The aim of our study was to reconsider the frequency of this pathology, to appreciate the maternal and fetal prognosis. PATIENTS AND METHODS: This was a retrospective cohort study, about 340 cases of PP, at the University Hospital of Cocody in Abidjan, during 5 years, from January 1st 2002 to December 31st 2006...
2009: Le Mali Médical
https://www.readbyqxmd.com/read/19402076/ultrasound-derived-fetal-size-nomogram-for-a-sub-saharan-african-population-a-longitudinal-study
#17
S H Landis, C V Ananth, V Lokomba, K E Hartmann, J M Thorp, A Horton, J Atibu, R W Ryder, A Tshefu, S R Meshnick
OBJECTIVES: To create a fetal size nomogram for use in sub-Saharan Africa and compare the derived centiles with reference intervals from developed countries. METHODS: Fetal biometric measurements were obtained at entry to antenatal care (11-22 weeks' gestation) and thereafter at 4-week intervals from pregnant women enrolled in a longitudinal ultrasound study in Kinshasa, Democratic Republic of Congo. The study population comprised 144 singleton gestations with ultrasound-derived gestational age within 14 days of the menstrual estimate...
October 2009: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/18973673/fetal-age-assessment-based-on-2nd-trimester-ultrasound-in-africa-and-the-effect-of-ethnicity
#18
Daniel Salpou, Torvid Kiserud, Svein Rasmussen, Synnøve Lian Johnsen
BACKGROUND: The African population is composed of a variety of ethnic groups, which differ considerably from each other. Some studies suggest that ethnic variation may influence dating. The aim of the present study was to establish reference values for fetal age assessment in Cameroon using two different ethnic groups (Fulani and Kirdi). METHODS: This was a prospective cross sectional study of 200 healthy pregnant women from Cameroon. The participants had regular menstrual periods and singleton uncomplicated pregnancies, and were recruited after informed consent...
2008: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/17259425/a-prospective-study-of-pyogenic-sepsis-of-the-hip-in-childhood
#19
T R Nunn, W Y Cheung, P D Rollinson
Between September 2004 and December 2005 we carried out a prospective study of all cases of sepsis of the hip in childhood at a South African regional hospital with a large local population, and which also took referrals from nine rural hospitals. The clinical, radiological, ultrasound and bacteriological features were assessed. All the hips were drained by arthrotomy and the diagnosis was confirmed microbiologically and histologically. Hips with tuberculosis were excluded. The children were reviewed in a dedicated clinic at a mean follow-up of 8...
January 2007: Journal of Bone and Joint Surgery. British Volume
https://www.readbyqxmd.com/read/16579803/randomised-trial-of-vitamin-a-supplementation-in-pregnant-women-in-rural-malawi-found-to-be-anaemic-on-screening-by-hemocue
#20
RANDOMIZED CONTROLLED TRIAL
N R van den Broek, S A White, C Flowers, J D Cook, E A Letsky, S A Tanumihardjo, C Mhango, M Molyneux, J P Neilson
OBJECTIVE: To assess the effects of vitamin A supplementation in women with anaemia during pregnancy. DESIGN: Single-centre randomised controlled trial. SETTING: Rural community in southern Malawi, central Africa. POPULATION: Seven hundred women with singleton pregnancies at 12-24 weeks measured by ultrasound scan and with haemoglobin <11.0 g/dl by HemoCue screening method. Analysis was by intention to treat. All received iron and folate, and sulphadoxine/pyrimethamine for antimalarial prophylaxis...
May 2006: BJOG: An International Journal of Obstetrics and Gynaecology
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